Adrienne D. Cox - Publications

Affiliations: 
Genetics & Molecular Biology University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Genetics, Molecular Biology

115 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Zhang H, Schaefer A, Wang Y, Hodge RG, Blake DR, Diehl JN, Papageorge AG, Stachler MD, Liao J, Zhou J, Wu Z, Akarca FG, de Klerk LK, Derks S, Pierobon M, ... ... Cox AD, et al. Gain-of-Function RHOA Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer. Cancer Discovery. PMID 31771969 DOI: 10.1158/2159-8290.CD-19-0811  0.72
2019 Hobbs GA, Baker NM, Miermont AM, Thurman RD, Pierobon M, Tran TH, Anderson AO, Waters AM, Diehl JN, Papke B, Hodge RG, Klomp JE, Goodwin CM, DeLiberty JM, Wang J, ... ... Cox AD, et al. Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer. Cancer Discovery. PMID 31649109 DOI: 10.1158/2159-8290.CD-19-1006  0.72
2019 Blake DR, Vaseva AV, Hodge RG, Kline MP, Gilbert TSK, Tyagi V, Huang D, Whiten GC, Larson JE, Wang X, Pearce KH, Herring LE, Graves LM, Frye SV, Emanuele MJ, ... Cox AD, et al. Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer. Science Signaling. 12. PMID 31311847 DOI: 10.1126/scisignal.aav7259  0.72
2019 Bryant KL, Stalnecker CA, Zeitouni D, Klomp JE, Peng S, Tikunov AP, Gunda V, Pierobon M, Waters AM, George SD, Tomar G, Papke B, Hobbs GA, Yan L, Hayes TK, ... ... Cox AD, et al. Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer. Nature Medicine. PMID 30833752 DOI: 10.1038/s41591-019-0368-8  0.72
2018 Vaseva AV, Blake DR, Gilbert TSK, Ng S, Hostetter G, Azam SH, Ozkan-Dagliyan I, Gautam P, Bryant KL, Pearce KH, Herring LE, Han H, Graves LM, Witkiewicz AK, Knudsen ES, ... ... Cox AD, et al. KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism. Cancer Cell. 34: 807-822.e7. PMID 30423298 DOI: 10.1016/j.ccell.2018.10.001  0.72
2017 Waters AM, Ozkan-Dagliyan I, Vaseva AV, Fer N, Strathern LA, Hobbs GA, Tessier-Cloutier B, Gillette WK, Bagni R, Whiteley GR, Hartley JL, McCormick F, Cox AD, Houghton PJ, Huntsman DG, et al. Evaluation of the selectivity and sensitivity of isoform- and mutation-specific RAS antibodies. Science Signaling. 10. PMID 28951536 DOI: 10.1126/scisignal.aao3332  0.72
2017 Justilien V, Ali SA, Jamieson L, Yin N, Cox AD, Der CJ, Murray NR, Fields AP. Ect2-Dependent rRNA Synthesis Is Required for KRAS-TRP53-Driven Lung Adenocarcinoma. Cancer Cell. PMID 28110998 DOI: 10.1016/j.ccell.2016.12.010  0.72
2016 Zhou B, Der CJ, Cox AD. The role of wild type RAS isoforms in cancer. Seminars in Cell & Developmental Biology. PMID 27422332 DOI: 10.1016/j.semcdb.2016.07.012  0.72
2016 Ryan MB, Finn AJ, Pedone KH, Thomas NE, Der CJ, Cox AD. ERK/MAPK Signaling Drives Overexpression of the Rac-GEF, PREX1, in BRAF- and NRAS-mutant Melanoma. Molecular Cancer Research : McR. PMID 27418645 DOI: 10.1158/1541-7786.MCR-16-0184  0.72
2016 Zhou B, Wang L, Zhang S, Bennett BD, He F, Zhang Y, Xiong C, Han L, Diao L, Li P, Fargo DC, Cox AD, Hu G. INO80 governs superenhancer-mediated oncogenic transcription and tumor growth in melanoma. Genes & Development. 30: 1440-53. PMID 27340176 DOI: 10.1101/gad.277178.115  0.76
2016 Zhou B, Ritt DA, Morrison DK, Der CJ, Cox AD. CK2alpha Maintains ERK Activity in a Kinase-independent Manner to Promote Resistance to Inhibitors of RAF and MEK but not ERK in BRAF-mutant Melanoma. The Journal of Biological Chemistry. PMID 27226552 DOI: 10.1074/jbc.M115.712885  0.72
2015 Ryan MB, Der CJ, Wang-Gillam A, Cox AD. Targeting RAS-mutant cancers: is ERK the key? Trends in Cancer. 1: 183-198. PMID 26858988 DOI: 10.1016/j.trecan.2015.10.001  0.76
2015 Hayes TK, Neel NF, Hu C, Gautam P, Chenard M, Long B, Aziz M, Kassner M, Bryant KL, Pierobon M, Marayati R, Kher S, George SD, Xu M, Wang-Gillam A, ... ... Cox AD, et al. Long-term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression. Cancer Cell. PMID 26725216 DOI: 10.1016/j.ccell.2015.11.011  0.72
2015 Zhou B, Cox AD. Up-front polytherapy for ALK-positive lung cancer. Nature Medicine. 21: 974-5. PMID 26340116 DOI: 10.1038/nm.3942  0.76
2015 Gentry LR, Nishimura A, Cox AD, Martin TD, Tsygankov D, Nishida M, Elston TC, Der CJ. Divergent Roles of CAAX Motif-Signaled Posttranslational Modifications in the Regulation and Subcellular Localization of Ral GTPases. The Journal of Biological Chemistry. PMID 26216878 DOI: 10.1074/jbc.M115.656710  0.76
2015 Kidd AR, Muñiz-Medina V, Der CJ, Cox AD, Reiner DJ. The C. elegans Chp/Wrch Ortholog CHW-1 Contributes to LIN-18/Ryk and LIN-17/Frizzled Signaling in Cell Polarity. Plos One. 10: e0133226. PMID 26208319 DOI: 10.1371/journal.pone.0133226  0.76
2015 Cox AD, Der CJ, Philips MR. Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery? Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 1819-27. PMID 25878363 DOI: 10.1158/1078-0432.CCR-14-3214  0.72
2015 Wang EC, Min Y, Palm RC, Fiordalisi JJ, Wagner KT, Hyder N, Cox AD, Caster JM, Tian X, Wang AZ. Nanoparticle formulations of histone deacetylase inhibitors for effective chemoradiotherapy in solid tumors. Biomaterials. 51: 208-15. PMID 25771011 DOI: 10.1016/j.biomaterials.2015.02.015  0.76
2015 Tsai FD, Lopes MS, Zhou M, Court H, Ponce O, Fiordalisi JJ, Gierut JJ, Cox AD, Haigis KM, Philips MR. K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif. Proceedings of the National Academy of Sciences of the United States of America. 112: 779-84. PMID 25561545 DOI: 10.1073/pnas.1412811112  0.76
2015 Hobbs GA, Mitchell LE, Arrington ME, Gunawardena HP, DeCristo MJ, Loeser RF, Chen X, Cox AD, Campbell SL. Redox regulation of Rac1 by thiol oxidation. Free Radical Biology & Medicine. 79: 237-50. PMID 25289457 DOI: 10.1016/j.freeradbiomed.2014.09.027  0.76
2015 Cox AD, Der CJ, Philips MR. Targeting RAS membrane association: Back to the future for anti-RAS drug discovery? Clinical Cancer Research. 21: 1819-1827. DOI: 10.1158/1078-0432.CCR-14-3214  0.76
2014 Cox AD, Fesik SW, Kimmelman AC, Luo J, Der CJ. Drugging the undruggable RAS: Mission possible? Nature Reviews. Drug Discovery. 13: 828-51. PMID 25323927 DOI: 10.1038/nrd4389  0.76
2014 Huff LP, DeCristo MJ, Cox AD. Effector recruitment method to study spatially regulated activation of Ras and Rho GTPases. Methods in Molecular Biology (Clifton, N.J.). 1120: 263-83. PMID 24470032 DOI: 10.1007/978-1-62703-791-4_18  0.76
2014 Zhou B, Cox AD. Posttranslational modifications of small G proteins Ras Superfamily Small G Proteins: Biology and Mechanisms 1: General Features, Signaling. 99-131. DOI: 10.1007/978-3-7091-1806-1_5  0.76
2013 Huff LP, Decristo MJ, Trembath D, Kuan PF, Yim M, Liu J, Cook DR, Miller CR, Der CJ, Cox AD. The Role of Ect2 Nuclear RhoGEF Activity in Ovarian Cancer Cell Transformation. Genes & Cancer. 4: 460-75. PMID 24386507 DOI: 10.1177/1947601913514851  0.76
2013 Williams KA, Zhang M, Xiang S, Hu C, Wu JY, Zhang S, Ryan M, Cox AD, Der CJ, Fang B, Koomen J, Haura E, Bepler G, Nicosia SV, Matthias P, et al. Extracellular signal-regulated kinase (ERK) phosphorylates histone deacetylase 6 (HDAC6) at serine 1035 to stimulate cell migration. The Journal of Biological Chemistry. 288: 33156-70. PMID 24089523 DOI: 10.1074/jbc.M113.472506  0.76
2013 Fiordalisi JJ, Dewar BJ, Graves LM, Madigan JP, Cox AD. Src-mediated phosphorylation of the tyrosine phosphatase PRL-3 is required for PRL-3 promotion of Rho activation, motility and invasion. Plos One. 8: e64309. PMID 23691193 DOI: 10.1371/journal.pone.0064309  0.76
2013 Barkan B, Cox AD, Kloog Y. Ras inhibition boosts galectin-7 at the expense of galectin-1 to sensitize cells to apoptosis. Oncotarget. 4: 256-68. PMID 23530091 DOI: 10.18632/oncotarget.844  0.76
2013 Grunwald A, Gottfried I, Cox AD, Haklai R, Kloog Y, Ashery U. Rasosomes originate from the Golgi to dispense Ras signals Cell Death and Disease. 4. PMID 23412389 DOI: 10.1038/cddis.2013.16  0.76
2012 Cox AD, Olive KP. Silencing the killers: paracrine immune suppression in pancreatic cancer. Cancer Cell. 21: 715-6. PMID 22698396 DOI: 10.1016/j.ccr.2012.05.029  0.76
2012 Martin TD, Mitin N, Cox AD, Yeh JJ, Der CJ. Phosphorylation by protein kinase Cα regulates RalB small GTPase protein activation, subcellular localization, and effector utilization. The Journal of Biological Chemistry. 287: 14827-36. PMID 22393054 DOI: 10.1074/jbc.M112.344986  0.76
2012 Cox AD, Der CJ. The RAF inhibitor paradox revisited. Cancer Cell. 21: 147-9. PMID 22340588 DOI: 10.1016/j.ccr.2012.01.017  0.76
2011 Werner ME, Copp JA, Karve S, Cummings ND, Sukumar R, Li C, Napier ME, Chen RC, Cox AD, Wang AZ. Folate-targeted polymeric nanoparticle formulation of docetaxel is an effective molecularly targeted radiosensitizer with efficacy dependent on the timing of radiotherapy. Acs Nano. 5: 8990-8. PMID 22011071 DOI: 10.1021/nn203165z  0.76
2011 Kashatus DF, Lim KH, Brady DC, Pershing NL, Cox AD, Counter CM. RALA and RALBP1 regulate mitochondrial fission at mitosis. Nature Cell Biology. 13: 1108-15. PMID 21822277 DOI: 10.1038/ncb2310  0.76
2011 Xu D, Allsop SA, Witherspoon SM, Snider JL, Yeh JJ, Fiordalisi JJ, White CD, Williams D, Cox AD, Baines AT. The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells. Carcinogenesis. 32: 488-95. PMID 21262926 DOI: 10.1093/carcin/bgr007  0.76
2011 Hodges-Loaiza HB, Parker LE, Cox AD. Prenylation and Phosphorylation of Ras Superfamily Small GTPases Enzymes. 30: 43-69. DOI: 10.1016/B978-0-12-415922-8.00003-3  0.76
2010 Cox AD, Der CJ. Ras history: The saga continues. Small Gtpases. 1: 2-27. PMID 21686117 DOI: 10.4161/sgtp.1.1.12178  0.76
2010 Campbell PM, Boufaied N, Fiordalisi JJ, Cox AD, Falardeau P, Der CJ, Gourdeau H. TLN-4601 suppresses growth and induces apoptosis of pancreatic carcinoma cells through inhibition of Ras-ERK MAPK signaling. Journal of Molecular Signaling. 5: 18. PMID 21044336 DOI: 10.1186/1750-2187-5-18  0.76
2010 Kidd AR, Snider JL, Martin TD, Graboski SF, Der CJ, Cox AD. Ras-related small GTPases RalA and RalB regulate cellular survival after ionizing radiation. International Journal of Radiation Oncology, Biology, Physics. 78: 205-12. PMID 20619549 DOI: 10.1016/j.ijrobp.2010.03.023  0.76
2010 Cox AD. Protein localization: Can too much lipid glue stop Ras? Nature Chemical Biology. 6: 483-5. PMID 20559313 DOI: 10.1038/nchembio.399  0.76
2010 Alan JK, Berzat AC, Dewar BJ, Graves LM, Cox AD. Regulation of the Rho family small GTPase Wrch-1/RhoU by C-terminal tyrosine phosphorylation requires Src. Molecular and Cellular Biology. 30: 4324-38. PMID 20547754 DOI: 10.1128/MCB.01646-09  0.76
2010 Cox AD, Der CJ. The raf inhibitor paradox: unexpected consequences of targeted drugs. Cancer Cell. 17: 221-3. PMID 20227037 DOI: 10.1016/j.ccr.2010.02.029  0.76
2010 González-Pérez V, Reiner DJ, Alan JK, Mitchell C, Edwards LJ, Khazak V, Der CJ, Cox AD. Genetic and functional characterization of putative Ras/Raf interaction inhibitors in C. elegans and mammalian cells. Journal of Molecular Signaling. 5: 2. PMID 20178605 DOI: 10.1186/1750-2187-5-2  0.76
2010 Kimple RJ, Vaseva AV, Cox AD, Baerman KM, Calvo BF, Tepper JE, Shields JM, Sartor CI. Radiosensitization of epidermal growth factor receptor/HER2-positive pancreatic cancer is mediated by inhibition of Akt independent of ras mutational status. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 912-23. PMID 20103665 DOI: 10.1158/1078-0432.CCR-09-1324  0.76
2010 Lim KH, Brady DC, Kashatus DF, Ancrile BB, Der CJ, Cox AD, Counter CM. Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA. Molecular and Cellular Biology. 30: 508-23. PMID 19901077 DOI: 10.1128/MCB.00916-08  0.76
2010 Hanker AB, Mitin N, Wilder RS, Henske EP, Tamanoi F, Cox AD, Der CJ. Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling. Oncogene. 29: 380-91. PMID 19838215 DOI: 10.1038/onc.2009.336  0.76
2009 Madigan JP, Bodemann BO, Brady DC, Dewar BJ, Keller PJ, Leitges M, Philips MR, Ridley AJ, Der CJ, Cox AD. Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation. The Biochemical Journal. 424: 153-61. PMID 19723022 DOI: 10.1042/BJ20082377  0.76
2009 Brady DC, Alan JK, Madigan JP, Fanning AS, Cox AD. The transforming Rho family GTPase Wrch-1 disrupts epithelial cell tight junctions and epithelial morphogenesis. Molecular and Cellular Biology. 29: 1035-49. PMID 19064640 DOI: 10.1128/MCB.00336-08  0.76
2008 Roberts PJ, Mitin N, Keller PJ, Chenette EJ, Madigan JP, Currin RO, Cox AD, Wilson O, Kirschmeier P, Der CJ. Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification. The Journal of Biological Chemistry. 283: 25150-63. PMID 18614539 DOI: 10.1074/jbc.M800882200  0.76
2008 Reiner DJ, González-Pérez V, Der CJ, Cox AD. Use of Caenorhabditis elegans to evaluate inhibitors of Ras function in vivo. Methods in Enzymology. 439: 425-49. PMID 18374181 DOI: 10.1016/S0076-6879(07)00430-2  0.76
2008 Blum R, Cox AD, Kloog Y. Inhibitors of chronically active ras: potential for treatment of human malignancies. Recent Patents On Anti-Cancer Drug Discovery. 3: 31-47. PMID 18289122 DOI: 10.2174/157489208783478702  0.76
2007 Thomas EK, Cancelas JA, Chae HD, Cox AD, Keller PJ, Perrotti D, Neviani P, Druker BJ, Setchell KD, Zheng Y, Harris CE, Williams DA. Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease. Cancer Cell. 12: 467-78. PMID 17996650 DOI: 10.1016/j.ccr.2007.10.015  0.76
2007 Falsetti SC, Wang DA, Peng H, Carrico D, Cox AD, Der CJ, Hamilton AD, Sebti SM. Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth. Molecular and Cellular Biology. 27: 8003-14. PMID 17875936 DOI: 10.1128/MCB.00057-07  0.76
2007 Philips MR, Cox AD. Geranylgeranyltransferase I as a target for anti-cancer drugs. The Journal of Clinical Investigation. 117: 1223-5. PMID 17476354 DOI: 10.1172/JCI32108  0.76
2006 Berzat AC, Brady DC, Fiordalisi JJ, Cox AD. Using inhibitors of prenylation to block localization and transforming activity. Methods in Enzymology. 407: 575-97. PMID 16757354 DOI: 10.1016/S0076-6879(05)07046-1  0.76
2006 Baines AT, Lim KH, Shields JM, Lambert JM, Counter CM, Der CJ, Cox AD. Use of retrovirus expression of interfering RNA to determine the contribution of activated K-Ras and ras effector expression to human tumor cell growth. Methods in Enzymology. 407: 556-74. PMID 16757353 DOI: 10.1016/S0076-6879(05)07045-X  0.76
2006 Fiordalisi JJ, Keller PJ, Cox AD. PRL tyrosine phosphatases regulate rho family GTPases to promote invasion and motility. Cancer Research. 66: 3153-61. PMID 16540666 DOI: 10.1158/0008-5472.CAN-05-3116  0.76
2006 Bivona TG, Quatela SE, Bodemann BO, Ahearn IM, Soskis MJ, Mor A, Miura J, Wiener HH, Wright L, Saba SG, Yim D, Fein A, Pérez de Castro I, Li C, Thompson CB, ... Cox AD, et al. PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis. Molecular Cell. 21: 481-93. PMID 16483930 DOI: 10.1016/j.molcel.2006.01.012  0.76
2006 Shutes A, Berzat AC, Chenette EJ, Cox AD, Der CJ. Biochemical analyses of the Wrch atypical Rho family GTPases. Methods in Enzymology. 406: 11-26. PMID 16472646 DOI: 10.1016/S0076-6879(06)06002-2  0.76
2005 Keller PJ, Fiordalisi JJ, Berzat AC, Cox AD. Visual monitoring of post-translational lipid modifications using EGFP-GTPase probes in live cells. Methods (San Diego, Calif.). 37: 131-37. PMID 16288891 DOI: 10.1016/j.ymeth.2005.05.023  0.76
2005 Keller PJ, Gable CM, Wing MR, Cox AD. Rac3-mediated transformation requires multiple effector pathways. Cancer Research. 65: 9883-90. PMID 16267012 DOI: 10.1158/0008-5472.CAN-04-3116  0.76
2005 Capell BC, Erdos MR, Madigan JP, Fiordalisi JJ, Varga R, Conneely KN, Gordon LB, Der CJ, Cox AD, Collins FS. Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome. Proceedings of the National Academy of Sciences of the United States of America. 102: 12879-84. PMID 16129833 DOI: 10.1073/pnas.0506001102  0.76
2005 Berzat AC, Buss JE, Chenette EJ, Weinbaum CA, Shutes A, Der CJ, Minden A, Cox AD. Transforming activity of the Rho family GTPase, Wrch-1, a Wnt-regulated Cdc42 homolog, is dependent on a novel carboxyl-terminal palmitoylation motif. The Journal of Biological Chemistry. 280: 33055-65. PMID 16046391 DOI: 10.1074/jbc.M507362200  0.76
2005 Lim KH, Baines AT, Fiordalisi JJ, Shipitsin M, Feig LA, Cox AD, Der CJ, Counter CM. Activation of RalA is critical for Ras-induced tumorigenesis of human cells. Cancer Cell. 7: 533-45. PMID 15950903 DOI: 10.1016/j.ccr.2005.04.030  0.76
2004 Shutes A, Berzat AC, Cox AD, Der CJ. Atypical mechanism of regulation of the Wrch-1 Rho family small GTPase. Current Biology : Cb. 14: 2052-6. PMID 15556869 DOI: 10.1016/j.cub.2004.11.011  0.76
2004 Kloog Y, Cox AD. Prenyl-binding domains: potential targets for Ras inhibitors and anti-cancer drugs. Seminars in Cancer Biology. 14: 253-61. PMID 15219618 DOI: 10.1016/j.semcancer.2004.04.004  0.76
2004 Solski PA, Wilder RS, Rossman KL, Sondek J, Cox AD, Campbell SL, Der CJ. Requirement for C-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation. The Journal of Biological Chemistry. 279: 25226-33. PMID 15073184 DOI: 10.1074/jbc.M313792200  0.76
2004 Huang Y, Rangwala F, Fulkerson PC, Ling B, Reed E, Cox AD, Kamholz J, Ratner N. Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells. Oncogene. 23: 368-78. PMID 14724565 DOI: 10.1038/sj.onc.1207075  0.76
2004 Shalom-Feuerstein R, Lindenboim L, Stein R, Cox AD, Kloog Y. Restoration of sensitivity to anoikis in Ras-transformed rat intestinal epithelial cells by a Ras inhibitor Cell Death and Differentiation. 11: 244-247. PMID 14576773 DOI: 10.1038/sj.cdd.4401334  0.76
2003 Cox AD, Der CJ. The dark side of Ras: regulation of apoptosis. Oncogene. 22: 8999-9006. PMID 14663478 DOI: 10.1038/sj.onc.1207111  0.76
2003 Joyce PL, Cox AD. Rac1 and Rac3 are targets for geranylgeranyltransferase I inhibitor-mediated inhibition of signaling, transformation, and membrane ruffling. Cancer Research. 63: 7959-67. PMID 14633727  0.76
2003 Grana TM, Sartor CI, Cox AD. Epidermal growth factor receptor autocrine signaling in RIE-1 cells transformed by the Ras oncogene enhances radiation resistance. Cancer Research. 63: 7807-14. PMID 14633707  0.76
2003 Fiordalisi JJ, Johnson RL, Weinbaum CA, Sakabe K, Chen Z, Casey PJ, Cox AD. High affinity for farnesyltransferase and alternative prenylation contribute individually to K-Ras4B resistance to farnesyltransferase inhibitors. The Journal of Biological Chemistry. 278: 41718-27. PMID 12882980 DOI: 10.1074/jbc.M305733200  0.76
2003 Bivona TG, Pérez De Castro I, Ahearn IM, Grana TM, Chiu VK, Lockyer PJ, Cullen PJ, Pellicer A, Cox AD, Philips MR. Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1. Nature. 424: 694-8. PMID 12845332 DOI: 10.1038/nature01806  0.76
2003 Murphy GA, Cox AD, Der CJ. Role of R-Ras in Cell Growth Handbook of Cell Signaling. 2: 681-688. DOI: 10.1016/B978-012124546-7/50595-7  0.76
2002 Cox AD, Der CJ. Ras family signaling: therapeutic targeting. Cancer Biology & Therapy. 1: 599-606. PMID 12642680  0.76
2002 Cox AD, Der CJ. Farnesyltransferase inhibitors: promises and realities. Current Opinion in Pharmacology. 2: 388-93. PMID 12127871 DOI: 10.1016/B978-012124546-7/50605-7  0.76
2002 Grana TM, Rusyn EV, Zhou H, Sartor CI, Cox AD. Ras mediates radioresistance through both phosphatidylinositol 3-kinase-dependent and Raf-dependent but mitogen-activated protein kinase/extracellular signal-regulated kinase kinase-independent signaling pathways. Cancer Research. 62: 4142-50. PMID 12124353  0.76
2002 Hansen M, Rusyn EV, Hughes PE, Ginsberg MH, Cox AD, Willumsen BM. R-Ras C-terminal sequences are sufficient to confer R-Ras specificity to H-Ras. Oncogene. 21: 4448-61. PMID 12080475 DOI: 10.1038/sj.onc.1205538  0.76
2002 Chiu VK, Bivona T, Hach A, Sajous JB, Silletti J, Wiener H, Johnson RL, Cox AD, Philips MR. Ras signalling on the endoplasmic reticulum and the Golgi. Nature Cell Biology. 4: 343-50. PMID 11988737 DOI: 10.1038/ncb783  0.76
2002 Fiordalisi JJ, Holly SP, Johnson RL, Parise LV, Cox AD. A distinct class of dominant negative Ras mutants: cytosolic GTP-bound Ras effector domain mutants that inhibit Ras signaling and transformation and enhance cell adhesion. The Journal of Biological Chemistry. 277: 10813-23. PMID 11799108 DOI: 10.1074/jbc.M107684200  0.76
2001 Yamashina S, Konno A, Wheeler MD, Rusyn I, Rusyn EV, Cox AD, Thurman RG. Endothelial cells contain a glycine-gated chloride channel Nutrition and Cancer. 40: 197-204. PMID 11962256  0.76
2001 Cox AD. Farnesyltransferase inhibitors: Potential role in the treatment of cancer Drugs. 61: 723-732. PMID 11398905  0.76
2001 Alton G, Cox AD, Toussaint LG, Westwick JK. Functional proteomics analysis of GTPase signaling networks Methods in Enzymology. 332: 300-316. PMID 11305106 DOI: 10.1016/S0076-6879(01)32211-5  0.76
2001 Fiordalisi JJ, Johnson RL, Ulkü AS, Der CJ, Cox AD. Mammalian expression vectors for Ras family proteins: generation and use of expression constructs to analyze Ras family function. Methods in Enzymology. 332: 3-36. PMID 11305105 DOI: 10.1016/S0076-6879(01)32189-4  0.76
2000 Rusyn EV, Reynolds ER, Shao H, Grana TM, Chan TO, Andres DA, Cox AD. Rit, a non-lipid-modified Ras-related protein, transforms NIH3T3 cells without activating the ERK, JNK, p38 MAPK or PI3K/Akt pathways. Oncogene. 19: 4685-94. PMID 11032018 DOI: 10.1038/sj.onc.1203836  0.76
2000 Kloog Y, Cox AD. RAS inhibitors: Potential for cancer therapeutics Molecular Medicine Today. 6: 398-402. PMID 11006529 DOI: 10.1016/S1357-4310(00)01789-5  0.76
2000 Sherman LS, Atit R, Rosenbaum T, Cox AD, Ratner N. Single cell Ras-GTP analysis reveals altered Ras activity in a subpopulation of neurofibroma Schwann cells but not fibroblasts. The Journal of Biological Chemistry. 275: 30740-5. PMID 10900196 DOI: 10.1074/jbc.M001702200  0.76
1999 Sizemore N, Cox AD, Barnard JA, Oldham SM, Reynolds ER, Der CJ, Coffey RJ. Pharmacological inhibition of Ras-transformed epithelial cell growth is linked to down-regulation of epidermal growth factor-related peptides Gastroenterology. 117: 567-576. PMID 10464132 DOI: 10.1016/S0016-5085(99)70449-X  0.76
1999 Keely PJ, Rusyn EV, Cox AD, Parise LV. R-Ras signals through specific integrin α cytoplasmic domains to promote migration and invasion of breast epithelial cells Journal of Cell Biology. 145: 1077-1088. PMID 10352023 DOI: 10.1083/jcb.145.5.1077  0.76
1999 Kloog Y, Cox AD, Sinensky M. Concepts in Ras-directed therapy Expert Opinion On Investigational Drugs. 8: 2121-2140.  0.76
1998 Oldham SM, Cox AD, Reynolds ER, Sizemore NS, Coffey RJ, Der CJ. Ras, but not Src, transformation of RIE-1 epithelial cells is dependent on activation of the mitogen-activated protein kinase cascade Oncogene. 16: 2565-2573. PMID 9632133  0.76
1997 Cox AD, Der CJ. Farnesyltransferase inhibitors and cancer treatment: Targeting simply ras? Biochimica Et Biophysica Acta - Reviews On Cancer. 1333. PMID 9294018 DOI: 10.1016/S0304-419X(97)00011-5  0.76
1997 Huff SY, Quilliam LA, Cox AD, Der CJ. R-Ras is regulated by activators and effectors distinct from those that control Ras function Oncogene. 14: 133-143. PMID 9010215  0.76
1996 Willumsen BM, Cox AD, Solski PA, Der CJ, Buss JE. Novel determinants of H-Ras plasma membrane localization and transformation. Oncogene. 13: 1901-9. PMID 8934536  0.76
1996 Graham SM, Vojtek AB, Huff SY, Cox AD, Clark GJ, Cooper JA, Der CJ. TC21 causes transformation by Raf-independent signaling pathways Molecular and Cellular Biology. 16: 6132-6140. PMID 8887643  0.76
1996 William Blackstock A, Cox AD, Tepper JE. Treatment of pancreatic cancer: Current limitations, future possibilities Oncology. 10: 301-307. PMID 8820445  0.76
1996 Bernhard EJ, Kao G, Cox AD, Sebti SM, Hamilton AD, Muschel RJ, McKenna WG. The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts Cancer Research. 56: 1727-1730. PMID 8620483  0.76
1995 Clark GJ, Cox AD, Graham SM, Der CJ. Biological assays for Ras transformation Methods in Enzymology. 255: 395-412. PMID 8524126 DOI: 10.1016/S0076-6879(95)55042-9  0.76
1995 Cox AD, Solski PA, Jordan JD, Der CJ. Analysis of Ras protein expression in mammalian cells. Methods in Enzymology. 255: 195-220. PMID 8524103 DOI: 10.1016/S0076-6879(95)55023-2  0.76
1995 Cox AD. Mutation and analysis of prenylation signal sequences Methods in Enzymology. 250: 105-121. PMID 7651143 DOI: 10.1016/0076-6879(95)50066-9  0.76
1995 Zohn IE, Yu H, Li X, Cox AD, Earp HS. Angiotensin II stimulates calcium-dependent activation of c-Jun N-terminal kinase Molecular and Cellular Biology. 15: 6160-6168. PMID 7565768  0.76
1994 Graham SM, Cox AD, Drivas G, Rush MG, D'Eustachio P, Der CJ. Aberrant function of the Ras-related protein TC21/R-Ras2 triggers malignant transformation Molecular and Cellular Biology. 14: 4108-4115. PMID 8196649  0.76
1994 Cox AD, Garcia AM, Westwick JK, Kowalczyk JJ, Lewis MD, Brenner DA, Der CJ. The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic Ras signaling and transformation Journal of Biological Chemistry. 269: 19203-19206. PMID 8034681  0.76
1994 Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M, Karin M, Brenner DA. Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases Proceedings of the National Academy of Sciences of the United States of America. 91: 6030-6034. PMID 8016110 DOI: 10.1073/pnas.91.13.6030  0.76
1994 Cox AD, Brtva TR, Lowe DG, Der CJ. R-Ras induces malignant, but not morphologic, transformation of NIH3T3 cells Oncogene. 9: 3281-3288. PMID 7936652  0.76
1994 Cox AD, Der CJ. Biological assays for cellular transformation Methods in Enzymology. 238: 277-294. PMID 7799794 DOI: 10.1016/0076-6879(94)38026-0  0.76
1994 Hauser CA, Der CJ, Cox AD. Transcriptional activation analysis of oncogene function Methods in Enzymology. 238: 271-276. PMID 7799793 DOI: 10.1016/0076-6879(94)38025-2  0.76
1993 Cox AD, Graham SM, Solski PA, Buss JE, Der CJ. The carboxyl-terminal CXXX sequence of Gi alpha, but not Rab5 or Rab11, supports Ras processing and transforming activity. The Journal of Biological Chemistry. 268: 11548-52. PMID 8505289  0.76
1992 Kato K, Cox AD, Hisaka MM, Graham SM, Buss JE, Der CJ. Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity Proceedings of the National Academy of Sciences of the United States of America. 89: 6403-6407. PMID 1631135  0.76
1992 Cox AD, Der CJ. Protein prenylation: more than just glue? Current Opinion in Cell Biology. 4: 1008-1016. PMID 1485954 DOI: 10.1016/0955-0674(92)90133-W  0.76
1992 Cox AD, Der CJ. The ras/cholesterol connection: implications for ras oncogenicity Critical Reviews in Oncogenesis. 3: 365-400. PMID 1420445  0.76
1992 Khosravi-Far R, Cox AD, Kato K, Der CJ. Protein prenylation: key to ras function and cancer intervention? Cell Growth &Amp; Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 3: 461-469. PMID 1419908  0.76
1992 Cox AD, Hisaka MM, Buss JE, Der CJ. Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein Molecular and Cellular Biology. 12: 2606-2615. PMID 1375323  0.76
1991 Der CJ, Cox AD. Isoprenoid modification and plasma membrane association: Critical factors for ras oncogenicity Cancer Cells. 3: 331-340. PMID 1751286  0.76
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