| Year |
Citation |
Score |
| 2023 |
Wasserman JS, Faezov B, Patel KR, Kurimchak AN, Palacio SM, Fowle H, McEwan BC, Xu Q, Zhao Z, Cressey L, Johnson N, Duncan JS, Kettenbach AN, Dunbrack RL, Graña X. FAM122A ensures cell cycle interphase progression and checkpoint control as a SLiM-dependent substrate-competitive inhibitor to the B55⍺/PP2A phosphatase. Biorxiv : the Preprint Server For Biology. PMID 36945596 DOI: 10.1101/2023.03.06.531310 |
0.425 |
|
| 2021 |
Fowle H, Zhao Z, Xu Q, Wasserman JS, Wang X, Adeyemi M, Feiser F, Kurimchak AN, Atar D, McEwan BC, Kettenbach AN, Page R, Peti W, Dunbrack RL, Graña X. PP2A/B55α substrate recruitment as defined by the retinoblastoma-related protein p107. Elife. 10. PMID 34661528 DOI: 10.7554/eLife.63181 |
0.364 |
|
| 2020 |
Zhao Z, Fowle H, Valentine H, Liu Z, Tan Y, Pei J, Badal S, Testa JR, Graña X. Immortalization of human primary prostate epithelial cells via CRISPR inactivation of the CDKN2A locus and expression of telomerase. Prostate Cancer and Prostatic Diseases. PMID 32873916 DOI: 10.1038/S41391-020-00274-4 |
0.357 |
|
| 2019 |
Bayarmagnai B, Perrin L, Pourfarhangi KE, Graña X, Tüzel E, Gligorijevic B. Invadopodia-mediated ECM degradation is enriched in the G1 phase of the cell cycle. Journal of Cell Science. PMID 31533971 DOI: 10.1242/Jcs.227116 |
0.477 |
|
| 2019 |
Fowle H, Zhao Z, Graña X. PP2A holoenzymes, substrate specificity driving cellular functions and deregulation in cancer. Advances in Cancer Research. 144: 55-93. PMID 31349904 DOI: 10.1016/Bs.Acr.2019.03.009 |
0.438 |
|
| 2018 |
Zhang H, Pandey S, Travers M, Sun H, Morton G, Madzo J, Chung W, Khowsathit J, Perez-Leal O, Barrero CA, Merali C, Okamoto Y, Sato T, Pan J, Garriga J, et al. Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer. Cell. 175: 1244-1258.e26. PMID 30454645 DOI: 10.1016/J.Cell.2018.09.051 |
0.454 |
|
| 2018 |
Pandey S, Zhang H, Barrero CA, Merali S, Graña X, Issa J. Abstract 2995: CDK9 phosphorylates BRG1 chromatin remodeler Cancer Research. 78: 2995-2995. DOI: 10.1158/1538-7445.Am2018-2995 |
0.597 |
|
| 2018 |
Zhang H, Pandey S, Travers M, Khowsathit J, Morton G, Sum H, Barrero CA, Merali C, Okamoto Y, Sato T, Garriga J, Bhanu NV, Simithy J, Patel B, Madzo J, et al. Abstract 2952: Targeting CDK9 reactivates epigenetically silenced genes in cancer Cancer Research. 78: 2952-2952. DOI: 10.1158/1538-7445.Am2018-2952 |
0.453 |
|
| 2017 |
Zhao Z, Kurimchak A, Makhov P, Johnson K, Kolenko V, Duncan J, Graña X. Abstract LB-320: Reconstituting B55/protein phosphatase 2A activity in B55/PP2A-defective prostate cancer cells suppresses proliferation and tumorigenicity through pleiotropic mechanisms Cancer Research. 77. DOI: 10.1158/1538-7445.Am2017-Lb-320 |
0.403 |
|
| 2017 |
Zhang H, Raynal NJ-, Sato T, Okamoto Y, Garriga J, Garcia B, Morton G, Childers W, Jacobson MA, Baylin SB, Graña X, Abou-Gharbia M, Issa JJ. Abstract 5064: Identifying novel potential epigenetic anti-cancer drugs from natural compounds using a phenotypic-based screening Cancer Research. 77: 5064-5064. DOI: 10.1158/1538-7445.Am2017-5064 |
0.332 |
|
| 2016 |
Zhang H, Raynal NJ-, Sato T, Okamoto Y, Garriga J, Morton G, Childers W, Jacobson MA, Baylin SB, Graña X, Abou-Gharbia M, Issa JJ. Abstract 4701: A phenotypic cell-based screen to identify novel potential epigenetic anti-cancer drugs from natural compounds Cancer Research. 76: 4701-4701. DOI: 10.1158/1538-7445.Am2016-4701 |
0.369 |
|
| 2016 |
Zhao Z, kurimchak A, Adeyemi M, Woodruff P, Kolenko V, Graña X. Abstract 3662: Analysis of the tumor suppressor function of B55alpha, the PP2A regulatory subunit encoded by PPP2R2A, in prostate cancer cells Cancer Research. 76: 3662-3662. DOI: 10.1158/1538-7445.Am2016-3662 |
0.438 |
|
| 2015 |
Kurimchak A, Graña X. PP2A: more than a reset switch to activate pRB proteins during the cell cycle and in response to signaling cues. Cell Cycle (Georgetown, Tex.). 14: 18-30. PMID 25483052 DOI: 10.4161/15384101.2014.985069 |
0.584 |
|
| 2014 |
Garriga J, Graña X. CDK9 inhibition strategy defines distinct sets of target genes. Bmc Research Notes. 7: 301. PMID 24886624 DOI: 10.1186/1756-0500-7-301 |
0.528 |
|
| 2013 |
Cherrier T, Le Douce V, Eilebrecht S, Riclet R, Marban C, Dequiedt F, Goumon Y, Paillart JC, Mericskay M, Parlakian A, Bausero P, Abbas W, Herbein G, Kurdistani SK, Grana X, et al. CTIP2 is a negative regulator of P-TEFb. Proceedings of the National Academy of Sciences of the United States of America. 110: 12655-60. PMID 23852730 DOI: 10.1073/Pnas.1220136110 |
0.454 |
|
| 2013 |
Kurimchak A, Haines DS, Garriga J, Wu S, De Luca F, Sweredoski MJ, Deshaies RJ, Hess S, Graña X. Activation of p107 by fibroblast growth factor, which is essential for chondrocyte cell cycle exit, is mediated by the protein phosphatase 2A/B55α holoenzyme. Molecular and Cellular Biology. 33: 3330-42. PMID 23775125 DOI: 10.1128/Mcb.00082-13 |
0.497 |
|
| 2012 |
Kurimchak A, Graña X. PP2A Counterbalances Phosphorylation of pRB and Mitotic Proteins by Multiple CDKs: Potential Implications for PP2A Disruption in Cancer. Genes & Cancer. 3: 739-48. PMID 23634261 DOI: 10.1177/1947601912473479 |
0.498 |
|
| 2012 |
Keskin H, Garriga J, Georlette D, Graña X. Complex effects of flavopiridol on the expression of primary response genes. Cell Division. 7: 11. PMID 22458775 DOI: 10.1186/1747-1028-7-11 |
0.531 |
|
| 2012 |
Kurimchak A, Graña X. PP2A holoenzymes negatively and positively regulate cell cycle progression by dephosphorylating pocket proteins and multiple CDK substrates. Gene. 499: 1-7. PMID 22387205 DOI: 10.1016/J.Gene.2012.02.015 |
0.557 |
|
| 2012 |
Graña X. Introduction Current Themes on Cell Cycle and Cancer Genes & Cancer. 3: 612-613. DOI: 10.1177/1947601913479021 |
0.599 |
|
| 2010 |
Jayadeva G, Kurimchak A, Garriga J, Sotillo E, Davis AJ, Haines DS, Mumby M, Graña X. B55alpha PP2A holoenzymes modulate the phosphorylation status of the retinoblastoma-related protein p107 and its activation. The Journal of Biological Chemistry. 285: 29863-73. PMID 20663872 DOI: 10.1074/Jbc.M110.162354 |
0.747 |
|
| 2010 |
Reddy HK, Graña X, Dhanasekaran DN, Litvin J, Reddy EP. Requirement of Cdk4 for v-Ha-ras-Induced Breast Tumorigenesis and Activation of the v-ras-Induced Senescence Program by the R24C Mutation. Genes & Cancer. 1: 69-80. PMID 20634902 DOI: 10.1177/1947601909358105 |
0.318 |
|
| 2010 |
Rivadeneira DB, Mayhew CN, Thangavel C, Sotillo E, Reed CA, Graña X, Knudsen ES. Proliferative suppression by CDK4/6 inhibition: complex function of the retinoblastoma pathway in liver tissue and hepatoma cells. Gastroenterology. 138: 1920-30. PMID 20100483 DOI: 10.1053/J.Gastro.2010.01.007 |
0.364 |
|
| 2010 |
Garriga J, Xie H, Obradovic Z, Graña X. Selective control of gene expression by CDK9 in human cells. Journal of Cellular Physiology. 222: 200-8. PMID 19780058 DOI: 10.1002/Jcp.21938 |
0.499 |
|
| 2009 |
Sotillo E, Garriga J, Padgaonkar A, Kurimchak A, Cook JG, Graña X. Coordinated activation of the origin licensing factor CDC6 and CDK2 in resting human fibroblasts expressing SV40 small T antigen and cyclin E. The Journal of Biological Chemistry. 284: 14126-35. PMID 19321444 DOI: 10.1074/Jbc.M900687200 |
0.502 |
|
| 2008 |
Graña X. Downregulation of the phosphatase nuclear targeting subunit (PNUTS) triggers pRB dephosphorylation and apoptosis in pRB positive tumor cell lines. Cancer Biology & Therapy. 7: 842-4. PMID 18497566 DOI: 10.4161/Cbt.7.6.6298 |
0.389 |
|
| 2008 |
Sotillo E, Garriga J, Kurimchak A, Graña X. Cyclin E and SV40 small T antigen cooperate to bypass quiescence and contribute to transformation by activating CDK2 in human fibroblasts. The Journal of Biological Chemistry. 283: 11280-92. PMID 18276582 DOI: 10.1074/Jbc.M709055200 |
0.528 |
|
| 2007 |
Salerno D, Hasham MG, Marshall R, Garriga J, Tsygankov AY, Graña X. Direct inhibition of CDK9 blocks HIV-1 replication without preventing T-cell activation in primary human peripheral blood lymphocytes. Gene. 405: 65-78. PMID 17949927 DOI: 10.1016/J.Gene.2007.09.010 |
0.683 |
|
| 2007 |
Carbone CJ, Graña X, Reddy EP, Haines DS. p21 loss cooperates with INK4 inactivation facilitating immortalization and Bcl-2-mediated anchorage-independent growth of oncogene-transduced primary mouse fibroblasts. Cancer Research. 67: 4130-7. PMID 17483323 DOI: 10.1158/0008-5472.Can-07-0499 |
0.435 |
|
| 2006 |
Marshall RM, Grana X. Mechanisms controlling CDK9 activity. Frontiers in Bioscience : a Journal and Virtual Library. 11: 2598-613. PMID 16720337 DOI: 10.2741/1994 |
0.533 |
|
| 2006 |
Salerno D, Hasham M, Marshall R, Garriga J, Tsygankov A, Graña X. Differential effects on HIV replication and T cell activation following direct inhibition of CDK9 or flavopiridol (FVP) treatment in primary peripheral blood lymphocytes Retrovirology. 3: 56. DOI: 10.1186/1742-4690-3-S1-P56 |
0.697 |
|
| 2005 |
Reddy HK, Mettus RV, Rane SG, Graña X, Litvin J, Reddy EP. Cyclin-dependent kinase 4 expression is essential for neu-induced breast tumorigenesis. Cancer Research. 65: 10174-8. PMID 16288002 DOI: 10.1158/0008-5472.Can-05-2639 |
0.429 |
|
| 2005 |
Marshall RM, Salerno D, Garriga J, Graña X. Cyclin T1 expression is regulated by multiple signaling pathways and mechanisms during activation of human peripheral blood lymphocytes. Journal of Immunology (Baltimore, Md. : 1950). 175: 6402-11. PMID 16272292 DOI: 10.4049/Jimmunol.175.10.6402 |
0.711 |
|
| 2004 |
Garriga J, Jayaraman AL, Limón A, Jayadeva G, Sotillo E, Truongcao M, Patsialou A, Wadzinski BE, Graña X. A dynamic equilibrium between CDKs and PP2A modulates phosphorylation of pRB, p107 and p130. Cell Cycle (Georgetown, Tex.). 3: 1320-30. PMID 15467457 DOI: 10.4161/Cc.3.10.1183 |
0.755 |
|
| 2004 |
Calbó J, Serna C, Garriga J, Graña X, Mazo A. The fate of pancreatic tumor cell lines following p16 overexpression depends on the modulation of CDK2 activity Cell Death and Differentiation. 11: 1055-1065. PMID 15309028 DOI: 10.1038/Sj.Cdd.4401481 |
0.541 |
|
| 2004 |
Garriga J, Graña X. Cellular control of gene expression by T-type cyclin/CDK9 complexes. Gene. 337: 15-23. PMID 15276198 DOI: 10.1016/J.Gene.2004.05.007 |
0.499 |
|
| 2003 |
Garriga J, Bhattacharya S, Calbó J, Marshall RM, Truongcao M, Haines DS, Graña X. CDK9 is constitutively expressed throughout the cell cycle, and its steady-state expression is independent of SKP2. Molecular and Cellular Biology. 23: 5165-73. PMID 12861003 DOI: 10.1128/Mcb.23.15.5165-5173.2003 |
0.609 |
|
| 2003 |
Bhattacharya S, Garriga J, Calbó J, Yong T, Haines DS, Graña X. SKP2 associates with p130 and accelerates p130 ubiquitylation and degradation in human cells. Oncogene. 22: 2443-51. PMID 12717421 DOI: 10.1038/Sj.Onc.1206339 |
0.513 |
|
| 2002 |
Calbó J, Parreño M, Sotillo E, Yong T, Mazo A, Garriga J, Grana X. G1 cyclin/cyclin-dependent kinase-coordinated phosphorylation of endogenous pocket proteins differentially regulates their interactions with E2F4 and E2F1 and gene expression. The Journal of Biological Chemistry. 277: 50263-74. PMID 12401786 DOI: 10.1074/Jbc.M209181200 |
0.613 |
|
| 2002 |
Rane SG, Mangan JK, Amanullah A, Wong BC, Vora RK, Liebermann DA, Hoffman B, Graña X, Reddy EP. Activation of the Jak3 pathway is associated with granulocytic differentiation of myeloid precursor cells. Blood. 100: 2753-62. PMID 12351382 DOI: 10.1182/Blood.V100.8.2753 |
0.544 |
|
| 2001 |
Parreño M, Garriga J, Limón A, Albrecht JH, Graña X. E1A modulates phosphorylation of p130 and p107 by differentially regulating the activity of G1/S cyclin/CDK complexes. Oncogene. 20: 4793-4806. PMID 11521191 DOI: 10.1038/Sj.Onc.1204644 |
0.573 |
|
| 2000 |
Parreño M, Garriga J, Limón A, Mayol X, Beck GR, Moran E, Graña X. E1A blocks hyperphosphorylation of p130 and p107 without affecting the phosphorylation status of the retinoblastoma protein. Journal of Virology. 74: 3166-76. PMID 10708433 DOI: 10.1128/Jvi.74.7.3166-3176.2000 |
0.519 |
|
| 1998 |
Graña X, Garriga J, Mayol X. Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth. Oncogene. 17: 3365-3383. PMID 9916999 DOI: 10.1038/Sj.Onc.1202575 |
0.522 |
|
| 1998 |
Garriga J, Peng J, Parreño M, Price DH, Henderson EE, Graña X. Upregulation of cyclin T1/CDK9 complexes during T cell activation Oncogene. 17: 3093-3102. PMID 9872325 DOI: 10.1038/Sj.Onc.1202548 |
0.54 |
|
| 1998 |
Fujinaga K, Cujec TP, Peng J, Garriga J, Price DH, Graña X, Peterlin BM. The ability of positive transcription elongation factor B to transactivate human immunodeficiency virus transcription depends on a functional kinase domain, cyclin T1, and Tat. Journal of Virology. 72: 7154-7159. PMID 9696809 DOI: 10.1128/Jvi.72.9.7154-7159.1998 |
0.52 |
|
| 1998 |
Garriga J, Limón A, Mayol X, Rane SG, Albrecht JH, Reddy EP, Andrés V, Graña X. Differential regulation of the retinoblastoma family of proteins during cell proliferation and differentiation. The Biochemical Journal. 333: 645-54. PMID 9677324 DOI: 10.1042/Bj3330645 |
0.562 |
|
| 1998 |
Mayol X, Grana X. The p130 pocket protein: keeping order at cell cycle exit/re-entrance transitions Frontiers in Bioscience : a Journal and Virtual Library. 3. PMID 9405335 DOI: 10.2741/A263 |
0.553 |
|
| 1997 |
Mayol X, Graña X. pRB, p107 and p130 as transcriptional regulators: Role in cell growth and differentiation Progress in Cell Cycle Research. 3: 157-169. PMID 9580269 DOI: 10.1007/978-1-4615-5371-7_13 |
0.519 |
|
| 1997 |
Jaumot M, Estañol JM, Casanovas O, Graña X, Agell N, Bachs O. The cell cycle inhibitor p21CIP is phosphorylated by cyclin A-CDK2 complexes. Biochemical and Biophysical Research Communications. 241: 434-438. PMID 9425288 DOI: 10.1006/Bbrc.1997.7787 |
0.55 |
|
| 1996 |
Garriga J, Segura E, Mayol X, Grubmeyer C, Graña X. Phosphorylation site specificity of the CDC2-related kinase PITALRE. The Biochemical Journal. 320: 983-9. PMID 9003389 DOI: 10.1042/Bj3200983 |
0.503 |
|
| 1996 |
Garriga J, Mayol X, Grana X. The CDC2-related kinase PITALRE is the catalytic subunit of active muitimeric protein complexes Biochemical Journal. 319: 293-298. PMID 8870681 DOI: 10.1042/Bj3190293 |
0.545 |
|
| 1995 |
Shakoori AR, Van Wijnen AJ, Cooper C, Aziz F, Birnbaum M, Reddy GPV, Grana X, De Luca A, Giordano A, Lian JB, Stein JL, Quesenberry P, Stein GS. Cytokine induction of proliferation and expression of CDC2 and cyclin A in FDC-P1 myeloid hematopoietic progenitor cells: Regulation of ubiquitous and cell cycle-dependent histone gene transcription factors Journal of Cellular Biochemistry. 59: 291-302. PMID 8567748 DOI: 10.1002/Jcb.240590302 |
0.499 |
|
| 1995 |
Guillouf C, Grana X, Selvakumaran M, De Luca A, Giordano A, Hoffman B, Liebermann DA. Dissection of the genetic programs of p53-mediated G1 growth arrest and apoptosis: Blocking p53-induced apoptosis unmasks G1 arrest Blood. 85: 2691-2698. PMID 7742528 DOI: 10.1182/Blood.V85.10.2691.Bloodjournal85102691 |
0.463 |
|
| 1995 |
Grana X, Reddy EP. Cell cycle control in mammalian cells: Role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs) Oncogene. 11: 211-219. PMID 7624138 |
0.445 |
|
| 1994 |
Graña X, De Luca A, Sang N, Fu Y, Claudio PP, Rosenblatt J, Morgan DO, Giordano A. PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro. Proceedings of the National Academy of Sciences of the United States of America. 91: 3834-8. PMID 8170997 DOI: 10.1073/Pnas.91.9.3834 |
0.555 |
|
| 1994 |
Jaumot M, Grana X, Giordano A, Reddy PV, Agell N, Bachs O. Cyclin/cdk2 Complexes in the Nucleus of HeLa Cells Biochemical and Biophysical Research Communications. 203: 1527-1534. PMID 7945302 DOI: 10.1006/Bbrc.1994.2359 |
0.445 |
|
| 1994 |
Wijnen AJv, Aziz F, Graña X, Luca AD, Desai RK, Jaarsveld K, Soprano K, Giordano A, Lian JB. Transcription of histone H4, H3, and H1 cell cycle genes: promoter factor HiNF-D contains CDC2, cyclin A, and an RB-related protein Proceedings of the National Academy of Sciences of the United States of America. 91: 12882-12886. PMID 7809140 DOI: 10.1073/Pnas.91.26.12882 |
0.413 |
|
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