Ronald C. Wek - Publications

Affiliations: 
Biochemistry and Molecular Biology Indiana University, Bloomington, Bloomington, IN, United States 
Area:
Molecular Biology

124 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Staschke KA, Wek RC. Adapting to cell stress from inside and out. Nature Cell Biology. 21: 799-800. PMID 31263267 DOI: 10.1038/s41556-019-0354-x  1
2019 Augusto L, Amin PH, Wek RC, Sullivan WJ. Regulation of arginine transport by GCN2 eIF2 kinase is important for replication of the intracellular parasite Toxoplasma gondii. Plos Pathogens. 15: e1007746. PMID 31194856 DOI: 10.1371/journal.ppat.1007746  0.6
2019 Holmes MJ, Shah P, Wek RC, Sullivan WJ. Simultaneous Ribosome Profiling of Human Host Cells Infected with Toxoplasma gondii. Msphere. 4. PMID 31167946 DOI: 10.1128/mSphere.00292-19  0.6
2019 Martynowicz J, Augusto L, Wek RC, Boehm SL, Sullivan WJ. Guanabenz Reverses a Key Behavioral Change Caused by Latent Toxoplasmosis in Mice by Reducing Neuroinflammation. Mbio. 10. PMID 31040237 DOI: 10.1128/mBio.00381-19  0.6
2018 Augusto L, Martynowicz J, Staschke KA, Wek RC, Sullivan WJ. Effects of PERK eIF2α kinase inhibitor against . Antimicrobial Agents and Chemotherapy. PMID 30181373 DOI: 10.1128/AAC.01442-18  1
2017 Zhang M, Gallego-Delgado J, Fernandez-Arias C, Waters NC, Rodriguez A, Tsuji M, Wek RC, Nussenzweig V, Sullivan WJ. Inhibiting the Plasmodium eIF2α Kinase PK4 Prevents Artemisinin-Induced Latency. Cell Host & Microbe. 22: 766-776.e4. PMID 29241041 DOI: 10.1016/j.chom.2017.11.005  0.6
2017 Collier AE, Spandau DF, Wek RC. Translational control of a human CDKN1A mRNA splice variant regulates the fate of UVB-irradiated human keratinocytes. Molecular Biology of the Cell. PMID 29118075 DOI: 10.1091/mbc.E17-06-0362  0.52
2017 Holmes MJ, Augusto LDS, Zhang M, Wek RC, Sullivan WJ. Translational Control in the Latency of Apicomplexan Parasites. Trends in Parasitology. PMID 28942109 DOI: 10.1016/j.pt.2017.08.006  0.6
2017 Willy JA, Young SK, Mosley AL, Gawrieh S, Stevens JL, Masuoka HC, Wek RC. Function of Inhibitor of Brutons Tyrosine Kinase Isoform α (IBTKα) in Nonalcoholic Steatohepatitis links Autophagy and the Unfolded Protein Response. The Journal of Biological Chemistry. PMID 28710282 DOI: 10.1074/jbc.M117.799304  0.4
2017 Collier AE, Wek RC, Spandau DF. Human keratinocyte differentiation requires translational control by the eIF2α kinase GCN2. The Journal of Investigative Dermatology. PMID 28528168 DOI: 10.1016/j.jid.2017.04.029  0.52
2016 Young SK, Wek RC. Upstream open reading frames differentially regulate gene-specific translation in the Integrated Stress Response. The Journal of Biological Chemistry. PMID 27358398 DOI: 10.1074/jbc.R116.733899  0.4
2016 Young SK, Shao Y, Bidwell JP, Wek RC. Nuclear Matrix Protein 4 is a Novel Regulator of Ribosome Biogenesis and Controls the Unfolded Protein Response Via Repression of Gadd34 Expression. The Journal of Biological Chemistry. PMID 27129771 DOI: 10.1074/jbc.M116.729830  0.92
2016 Young SK, Baird TD, Wek RC. Translation regulation of the glutamyl-prolyl-tRNA synthetase gene EPRS through bypass of uORFs with non-canonical initiation codons. The Journal of Biological Chemistry. PMID 27002157 DOI: 10.1074/jbc.M116.722256  0.92
2016 Fusakio ME, Willy JA, Wang Y, Mirek ET, Baghdadi RJ, Adams CM, Anthony TG, Wek RC. Transcription factor ATF4 directs basal and select induced gene expression in the unfolded protein response and cholesterol metabolism in liver. Molecular Biology of the Cell. PMID 26960794 DOI: 10.1091/mbc.E16-01-0039  0.92
2016 Young SK, Palam LR, Wu C, Sachs MS, Wek RC. Ribosome Elongation Stall Directs Gene-Specific Translation In the Integrated Stress Response. The Journal of Biological Chemistry. PMID 26817837 DOI: 10.1074/jbc.M115.705640  0.92
2015 Young SK, Willy JA, Wu C, Sachs MS, Wek RC. Ribosome Reinitiation Directs Gene-Specific Translation and Regulates the Integrated Stress Response. The Journal of Biological Chemistry. PMID 26446796 DOI: 10.1074/jbc.M115.693184  0.92
2015 Benmerzouga I, Checkley LA, Ferdig MT, Arrizabalaga G, Wek RC, Sullivan WJ. Guanabenz repurposed as an antiparasitic with activity against acute and latent toxoplasmosis. Antimicrobial Agents and Chemotherapy. 59: 6939-45. PMID 26303803 DOI: 10.1128/AAC.01683-15  0.92
2015 Collier AE, Wek RC, Spandau DF. Translational Repression Protects Human Keratinocytes from UVB-Induced Apoptosis through a Discordant eIF2 Kinase Stress Response. The Journal of Investigative Dermatology. 135: 2502-11. PMID 25950825 DOI: 10.1038/jid.2015.177  0.52
2015 Willy JA, Young SK, Stevens JL, Masuoka HC, Wek RC. CHOP links endoplasmic reticulum stress to NF-κB activation in the pathogenesis of nonalcoholic steatohepatitis. Molecular Biology of the Cell. 26: 2190-204. PMID 25904325 DOI: 10.1091/mbc.E15-01-0036  0.92
2015 Wilson GJ, Lennox BA, She P, Mirek ET, Al Baghdadi RJ, Fusakio ME, Dixon JL, Henderson GC, Wek RC, Anthony TG. GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment. American Journal of Physiology. Endocrinology and Metabolism. 308: E283-93. PMID 25491724 DOI: 10.1152/ajpendo.00361.2014  0.92
2015 Gao R, Chen S, Kobayashi M, Yu H, Zhang Y, Wan Y, Young SK, Soltis A, Yu M, Vemula S, Fraenkel E, Cantor A, Antipin Y, Xu Y, Yoder MC, ... Wek RC, et al. Bmi1 promotes erythroid development through regulating ribosome biogenesis. Stem Cells (Dayton, Ohio). 33: 925-38. PMID 25385494 DOI: 10.1002/stem.1896  0.92
2015 Collier AE, Wek RC, F Spandau D. Translational Repression Protects Human Keratinocytes from UVB-Induced Apoptosis through a Discordant eIF2 Kinase Stress Response Journal of Investigative Dermatology. DOI: 10.1038/jid.2015.177  0.92
2014 He H, Singh I, Wek SA, Dey S, Baird TD, Wek RC, Georgiadis MM. Crystal structures of GCN2 protein kinase C-terminal domains suggest regulatory differences in yeast and mammals. The Journal of Biological Chemistry. 289: 15023-34. PMID 24719324 DOI: 10.1074/jbc.M114.560789  0.92
2014 Baird TD, Palam LR, Fusakio ME, Willy JA, Davis CM, McClintick JN, Anthony TG, Wek RC. Selective mRNA translation during eIF2 phosphorylation induces expression of IBTKα. Molecular Biology of the Cell. 25: 1686-97. PMID 24648495 DOI: 10.1091/mbc.E14-02-0704  0.92
2014 Cambiaghi TD, Pereira CM, Shanmugam R, Bolech M, Wek RC, Sattlegger E, Castilho BA. Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2. Biochemical and Biophysical Research Communications. 443: 592-7. PMID 24333428 DOI: 10.1016/j.bbrc.2013.12.021  0.92
2014 Konrad C, Wek RC, Sullivan WJ. GCN2-like eIF2α kinase manages the amino acid starvation response in Toxoplasma gondii. International Journal For Parasitology. 44: 139-46. PMID 24126185 DOI: 10.1016/j.ijpara.2013.08.005  0.92
2013 She P, Bunpo P, Cundiff JK, Wek RC, Harris RA, Anthony TG. General control nonderepressible 2 (GCN2) kinase protects oligodendrocytes and white matter during branched-chain amino acid deficiency in mice. The Journal of Biological Chemistry. 288: 31250-60. PMID 24019515 DOI: 10.1074/jbc.M113.498469  0.92
2013 Wilson GJ, Bunpo P, Cundiff JK, Wek RC, Anthony TG. The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment. American Journal of Physiology. Endocrinology and Metabolism. 305: E1124-33. PMID 24002574 DOI: 10.1152/ajpendo.00080.2013  0.92
2013 Teske BF, Fusakio ME, Zhou D, Shan J, McClintick JN, Kilberg MS, Wek RC. CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis. Molecular Biology of the Cell. 24: 2477-90. PMID 23761072 DOI: 10.1091/mbc.E13-01-0067  0.92
2013 Joyce BR, Tampaki Z, Kim K, Wek RC, Sullivan WJ. The unfolded protein response in the protozoan parasite Toxoplasma gondii features translational and transcriptional control. Eukaryotic Cell. 12: 979-89. PMID 23666622 DOI: 10.1128/EC.00021-13  0.92
2013 Babcock JT, Nguyen HB, He Y, Hendricks JW, Wek RC, Quilliam LA. Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response. The Journal of Biological Chemistry. 288: 15687-98. PMID 23612979 DOI: 10.1074/jbc.M112.431056  0.92
2013 Konrad C, Queener SF, Wek RC, Sullivan WJ. Inhibitors of eIF2α dephosphorylation slow replication and stabilize latency in Toxoplasma gondii. Antimicrobial Agents and Chemotherapy. 57: 1815-22. PMID 23380722 DOI: 10.1128/AAC.01899-12  0.92
2012 Anthony TG, Wek RC. TXNIP switches tracks toward a terminal UPR. Cell Metabolism. 16: 135-7. PMID 22883225 DOI: 10.1016/j.cmet.2012.07.012  0.92
2012 Trinh MA, Kaphzan H, Wek RC, Pierre P, Cavener DR, Klann E. Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility. Cell Reports. 1: 676-88. PMID 22813743 DOI: 10.1016/j.celrep.2012.04.010  0.92
2012 Baird TD, Wek RC. Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism. Advances in Nutrition (Bethesda, Md.). 3: 307-21. PMID 22585904 DOI: 10.3945/an.112.002113  0.92
2012 Dey S, Savant S, Teske BF, Hatzoglou M, Calkhoven CF, Wek RC. Transcriptional repression of ATF4 gene by CCAAT/enhancer-binding protein β (C/EBPβ) differentially regulates integrated stress response. The Journal of Biological Chemistry. 287: 21936-49. PMID 22556424 DOI: 10.1074/jbc.M112.351783  0.92
2012 Dai MS, Challagundla KB, Sun XX, Palam LR, Zeng SX, Wek RC, Lu H. Physical and functional interaction between ribosomal protein L11 and the tumor suppressor ARF. The Journal of Biological Chemistry. 287: 17120-9. PMID 22467867 DOI: 10.1074/jbc.M111.311902  0.92
2011 Teske BF, Wek SA, Bunpo P, Cundiff JK, McClintick JN, Anthony TG, Wek RC. The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress. Molecular Biology of the Cell. 22: 4390-405. PMID 21917591 DOI: 10.1091/mbc.E11-06-0510  0.92
2011 Konrad C, Wek RC, Sullivan WJ. A GCN2-like eukaryotic initiation factor 2 kinase increases the viability of extracellular Toxoplasma gondii parasites. Eukaryotic Cell. 10: 1403-12. PMID 21908594 DOI: 10.1128/EC.05117-11  0.92
2011 Singh CR, Watanabe R, Zhou D, Jennings MD, Fukao A, Lee B, Ikeda Y, Chiorini JA, Campbell SG, Ashe MP, Fujiwara T, Wek RC, Pavitt GD, Asano K. Mechanisms of translational regulation by a human eIF5-mimic protein. Nucleic Acids Research. 39: 8314-28. PMID 21745818 DOI: 10.1093/nar/gkr339  0.92
2011 Palam LR, Baird TD, Wek RC. Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation. The Journal of Biological Chemistry. 286: 10939-49. PMID 21285359 DOI: 10.1074/jbc.M110.216093  0.92
2011 Teske BF, Baird TD, Wek RC. Methods for analyzing eIF2 kinases and translational control in the unfolded protein response. Methods in Enzymology. 490: 333-56. PMID 21266259 DOI: 10.1016/B978-0-12-385114-7.00019-2  0.92
2011 Joyce BR, Konrad C, Wek RC, Sullivan WJ. Translation control is critical during acute and chronic stages of toxoplasmosis infection. Expert Review of Anti-Infective Therapy. 9: 1-3. PMID 21171869 DOI: 10.1586/eri.10.146  0.92
2010 Nemoto N, Udagawa T, Ohira T, Jiang L, Hirota K, Wilkinson CR, Bähler J, Jones N, Ohta K, Wek RC, Asano K. The roles of stress-activated Sty1 and Gcn2 kinases and of the protooncoprotein homologue Int6/eIF3e in responses to endogenous oxidative stress during histidine starvation. Journal of Molecular Biology. 404: 183-201. PMID 20875427 DOI: 10.1016/j.jmb.2010.09.016  0.92
2010 Bunpo P, Cundiff JK, Reinert RB, Wek RC, Aldrich CJ, Anthony TG. The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginase. The Journal of Nutrition. 140: 2020-7. PMID 20861212 DOI: 10.3945/jn.110.129197  0.92
2010 Joyce BR, Queener SF, Wek RC, Sullivan WJ. Phosphorylation of eukaryotic initiation factor-2{alpha} promotes the extracellular survival of obligate intracellular parasite Toxoplasma gondii. Proceedings of the National Academy of Sciences of the United States of America. 107: 17200-5. PMID 20855600 DOI: 10.1073/pnas.1007610107  0.92
2010 Dey S, Baird TD, Zhou D, Palam LR, Spandau DF, Wek RC. Both transcriptional regulation and translational control of ATF4 are central to the integrated stress response. The Journal of Biological Chemistry. 285: 33165-74. PMID 20732869 DOI: 10.1074/jbc.M110.167213  0.92
2010 Zaborske JM, Wu X, Wek RC, Pan T. Selective control of amino acid metabolism by the GCN2 eIF2 kinase pathway in Saccharomyces cerevisiae. Bmc Biochemistry. 11: 29. PMID 20684782 DOI: 10.1186/1471-2091-11-29  0.92
2010 Wek RC, Staschke KA. How do tumours adapt to nutrient stress? The Embo Journal. 29: 1946-7. PMID 20551969 DOI: 10.1038/emboj.2010.110  0.92
2010 Wek RC, Anthony TG. Obesity: stressing about unfolded proteins. Nature Medicine. 16: 374-6. PMID 20376042 DOI: 10.1038/nm0410-374  0.92
2010 Staschke KA, Dey S, Zaborske JM, Palam LR, McClintick JN, Pan T, Edenberg HJ, Wek RC. Integration of general amino acid control and target of rapamycin (TOR) regulatory pathways in nitrogen assimilation in yeast. The Journal of Biological Chemistry. 285: 16893-911. PMID 20233714 DOI: 10.1074/jbc.M110.121947  0.92
2009 Bunpo P, Dudley A, Cundiff JK, Cavener DR, Wek RC, Anthony TG. GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase. The Journal of Biological Chemistry. 284: 32742-9. PMID 19783659 DOI: 10.1074/jbc.M109.047910  0.92
2009 Huang CC, Chiribau CB, Majumder M, Chiang CM, Wek RC, Kelm RJ, Khalili K, Snider MD, Hatzoglou M. A bifunctional intronic element regulates the expression of the arginine/lysine transporter Cat-1 via mechanisms involving the purine-rich element binding protein A (Pur alpha). The Journal of Biological Chemistry. 284: 32312-20. PMID 19720825 DOI: 10.1074/jbc.M109.024471  0.92
2009 Wek RC, Anthony TG. Beta testing the antioxidant function of eIF2alpha phosphorylation in diabetes prevention. Cell Metabolism. 10: 1-2. PMID 19583945 DOI: 10.1016/j.cmet.2009.06.005  0.92
2009 Zaborske JM, Narasimhan J, Jiang L, Wek SA, Dittmar KA, Freimoser F, Pan T, Wek RC. Genome-wide analysis of tRNA charging and activation of the eIF2 kinase Gcn2p. The Journal of Biological Chemistry. 284: 25254-67. PMID 19546227 DOI: 10.1074/jbc.M109.000877  0.92
2009 Butler JS, Palam LR, Tate CM, Sanford JR, Wek RC, Skalnik DG. DNA Methyltransferase protein synthesis is reduced in CXXC finger protein 1-deficient embryonic stem cells. Dna and Cell Biology. 28: 223-31. PMID 19388845 DOI: 10.1089/dna.2009.0854  0.92
2008 Vonlaufen N, Kanzok SM, Wek RC, Sullivan WJ. Stress response pathways in protozoan parasites. Cellular Microbiology. 10: 2387-99. PMID 18647172 DOI: 10.1111/j.1462-5822.2008.01210.x  0.92
2008 Udagawa T, Nemoto N, Wilkinson CR, Narashimhan J, Jiang L, Watt S, Zook A, Jones N, Wek RC, Bähler J, Asano K. Int6/eIF3e promotes general translation and Atf1 abundance to modulate Sty1 MAPK-dependent stress response in fission yeast. The Journal of Biological Chemistry. 283: 22063-75. PMID 18502752 DOI: 10.1074/jbc.M710017200  0.92
2008 Narasimhan J, Joyce BR, Naguleswaran A, Smith AT, Livingston MR, Dixon SE, Coppens I, Wek RC, Sullivan WJ. Translation regulation by eukaryotic initiation factor-2 kinases in the development of latent cysts in Toxoplasma gondii. The Journal of Biological Chemistry. 283: 16591-601. PMID 18420584 DOI: 10.1074/jbc.M800681200  0.92
2008 Neznanov N, Dragunsky EM, Chumakov KM, Neznanova L, Wek RC, Gudkov AV, Banerjee AK. Different effect of proteasome inhibition on vesicular stomatitis virus and poliovirus replication. Plos One. 3: e1887. PMID 18382670 DOI: 10.1371/journal.pone.0001887  0.92
2008 Liang F, Luo Y, Dong Y, Walls CD, Liang J, Jiang HY, Sanford JR, Wek RC, Zhang ZY. Translational control of C-terminal Src kinase (Csk) expression by PRL3 phosphatase. The Journal of Biological Chemistry. 283: 10339-46. PMID 18268019 DOI: 10.1074/jbc.M708285200  0.92
2008 Zhou D, Palam LR, Jiang L, Narasimhan J, Staschke KA, Wek RC. Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions. The Journal of Biological Chemistry. 283: 7064-73. PMID 18195013 DOI: 10.1074/jbc.M708530200  0.92
2008 Chambers KT, Unverferth JA, Weber SM, Wek RC, Urano F, Corbett JA. The role of nitric oxide and the unfolded protein response in cytokine-induced beta-cell death. Diabetes. 57: 124-32. PMID 17928398 DOI: 10.2337/db07-0944  0.92
2008 Gass JN, Jiang HY, Wek RC, Brewer JW. The unfolded protein response of B-lymphocytes: PERK-independent development of antibody-secreting cells. Molecular Immunology. 45: 1035-43. PMID 17822768 DOI: 10.1016/j.molimm.2007.07.029  0.92
2007 Wek RC, Cavener DR. Translational control and the unfolded protein response. Antioxidants & Redox Signaling. 9: 2357-71. PMID 17760508 DOI: 10.1089/ars.2007.1764  0.92
2007 Jiang HY, Jiang L, Wek RC. The eukaryotic initiation factor-2 kinase pathway facilitates differential GADD45a expression in response to environmental stress. The Journal of Biological Chemistry. 282: 3755-65. PMID 17170114 DOI: 10.1074/jbc.M606461200  0.92
2007 Lopez AB, Wang C, Huang CC, Yaman I, Li Y, Chakravarty K, Johnson PF, Chiang CM, Snider MD, Wek RC, Hatzoglou M. A feedback transcriptional mechanism controls the level of the arginine/lysine transporter cat-1 during amino acid starvation. The Biochemical Journal. 402: 163-73. PMID 17042743 DOI: 10.1042/BJ20060941  0.92
2006 Wek RC, Anthony TG. EXtENDINg beta cell survival by UPRegulating ATF4 translation. Cell Metabolism. 4: 333-4. PMID 17084705 DOI: 10.1016/j.cmet.2006.10.006  0.92
2006 Reinert RB, Oberle LM, Wek SA, Bunpo P, Wang XP, Mileva I, Goodwin LO, Aldrich CJ, Durden DL, McNurlan MA, Wek RC, Anthony TG. Role of glutamine depletion in directing tissue-specific nutrient stress responses to L-asparaginase. The Journal of Biological Chemistry. 281: 31222-33. PMID 16931516 DOI: 10.1074/jbc.M604511200  0.92
2006 Joshi MA, Jeoung NH, Obayashi M, Hattab EM, Brocken EG, Liechty EA, Kubek MJ, Vattem KM, Wek RC, Harris RA. Impaired growth and neurological abnormalities in branched-chain alpha-keto acid dehydrogenase kinase-deficient mice. The Biochemical Journal. 400: 153-62. PMID 16875466 DOI: 10.1042/BJ20060869  0.92
2006 Carnevalli LS, Pereira CM, Jaqueta CB, Alves VS, Paiva VN, Vattem KM, Wek RC, Mello LE, Castilho BA. Phosphorylation of the alpha subunit of translation initiation factor-2 by PKR mediates protein synthesis inhibition in the mouse brain during status epilepticus. The Biochemical Journal. 397: 187-94. PMID 16492139 DOI: 10.1042/BJ20051643  0.64
2006 Wek RC, Jiang HY, Anthony TG. Coping with stress: EIF2 kinases and translational control Biochemical Society Transactions. 34: 7-11. PMID 16246168  0.92
2005 Dunand-Sauthier I, Walker CA, Narasimhan J, Pearce AK, Wek RC, Humphrey TC. Stress-activated protein kinase pathway functions to support protein synthesis and translational adaptation in response to environmental stress in fission yeast. Eukaryotic Cell. 4: 1785-93. PMID 16278445 DOI: 10.1128/EC.4.11.1785-1793.2005  0.92
2005 Pereira CM, Sattlegger E, Jiang HY, Longo BM, Jaqueta CB, Hinnebusch AG, Wek RC, Mello LEAM, Castilho BA. IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation Journal of Biological Chemistry. 280: 28316-28323. PMID 15937339 DOI: 10.1074/jbc.M408571200  0.92
2005 Hao S, Sharp JW, Ross-Inta CM, McDaniel BJ, Anthony TG, Wek RC, Cavener DR, McGrath BC, Rudell JB, Koehnle TJ, Gietzen DW. Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex. Science (New York, N.Y.). 307: 1776-8. PMID 15774759 DOI: 10.1126/science.1104882  0.92
2005 Jiang HY, Wek RC. Phosphorylation of the alpha-subunit of the eukaryotic initiation factor-2 (eIF2alpha) reduces protein synthesis and enhances apoptosis in response to proteasome inhibition. The Journal of Biological Chemistry. 280: 14189-202. PMID 15684420 DOI: 10.1074/jbc.M413660200  0.92
2005 Jiang HY, Wek RC. GCN2 phosphorylation of eIF2alpha activates NF-kappaB in response to UV irradiation. The Biochemical Journal. 385: 371-80. PMID 15355306 DOI: 10.1042/BJ20041164  0.92
2004 Zhan K, Narasimhan J, Wek RC. Differential activation of eIF2 kinases in response to cellular stresses in Schizosaccharomyces pombe. Genetics. 168: 1867-75. PMID 15611163 DOI: 10.1534/genetics.104.031443  0.92
2004 Vattem KM, Wek RC. Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 11269-74. PMID 15277680 DOI: 10.1073/pnas.0400541101  0.92
2004 Senée V, Vattem KM, Delépine M, Rainbow LA, Haton C, Lecoq A, Shaw NJ, Robert JJ, Rooman R, Diatloff-Zito C, Michaud JL, Bin-Abbas B, Taha D, Zabel B, Franceschini P, ... ... Wek RC, et al. Wolcott-Rallison Syndrome: clinical, genetic, and functional study of EIF2AK3 mutations and suggestion of genetic heterogeneity. Diabetes. 53: 1876-83. PMID 15220213 DOI: 10.2337/diabetes.53.7.1876  0.92
2004 Anthony TG, McDaniel BJ, Byerley RL, McGrath BC, Cavener DR, McNurlan MA, Wek RC. Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2. The Journal of Biological Chemistry. 279: 36553-61. PMID 15213227 DOI: 10.1074/jbc.M404559200  0.92
2004 Narasimhan J, Staschke KA, Wek RC. Dimerization is required for activation of eIF2 kinase Gcn2 in response to diverse environmental stress conditions. The Journal of Biological Chemistry. 279: 22820-32. PMID 15010461 DOI: 10.1074/jbc.M402228200  0.92
2004 Sullivan WJ, Narasimhan J, Bhatti MM, Wek RC. Parasite-specific eIF2 (eukaryotic initiation factor-2) kinase required for stress-induced translation control. The Biochemical Journal. 380: 523-31. PMID 14989696 DOI: 10.1042/BJ20040262  0.92
2004 Jiang HY, Wek SA, McGrath BC, Lu D, Hai T, Harding HP, Wang X, Ron D, Cavener DR, Wek RC. Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response. Molecular and Cellular Biology. 24: 1365-77. PMID 14729979 DOI: 10.1128/MCB.24.3.1365-1377.2004  0.92
2003 Abe T, Lu X, Jiang Y, Boccone CE, Qian S, Vattem KM, Wek RC, Walsh JP. Site-directed mutagenesis of the active site of diacylglycerol kinase alpha: calcium and phosphatidylserine stimulate enzyme activity via distinct mechanisms. The Biochemical Journal. 375: 673-80. PMID 12908872 DOI: 10.1042/BJ20031052  0.92
2003 Jiang HY, Wek SA, McGrath BC, Scheuner D, Kaufman RJ, Cavener DR, Wek RC. Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses. Molecular and Cellular Biology. 23: 5651-63. PMID 12897138 DOI: 10.1128/MCB.23.16.5651-5663.2003  0.92
2002 Zhan K, Vattem KM, Bauer BN, Dever TE, Chen JJ, Wek RC. Phosphorylation of eukaryotic initiation factor 2 by heme-regulated inhibitor kinase-related protein kinases in Schizosaccharomyces pombe is important for resistance to environmental stresses Molecular and Cellular Biology. 22: 7134-7146. PMID 12242291 DOI: 10.1128/MCB.22.20.7134-7146.2002  0.92
2002 Zhang P, McGrath BC, Reinert J, Olsen DS, Lei L, Gill S, Wek SA, Vattem KM, Wek RC, Kimball SR, Jefferson LS, Cavener DR. The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice. Molecular and Cellular Biology. 22: 6681-8. PMID 12215525 DOI: 10.1128/MCB.22.19.6681-6688.2002  0.92
2002 Ma K, Vattem KM, Wek RC. Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress. The Journal of Biological Chemistry. 277: 18728-35. PMID 11907036 DOI: 10.1074/jbc.M200903200  0.92
2002 Fernandez J, Yaman I, Merrick WC, Koromilas A, Wek RC, Sood R, Hensold J, Hatzoglou M. Regulation of internal ribosome entry site-mediated translation by eukaryotic initiation factor-2α phosphorylation and translation of a small upstream open reading frame Journal of Biological Chemistry. 277: 2050-2058. PMID 11684693 DOI: 10.1074/jbc.M109199200  0.92
2001 Vattem KM, Staschke KA, Wek RC. Mechanism of activation of the double-stranded-RNA-dependent protein kinase, PKR: role of dimerization and cellular localization in the stimulation of PKR phosphorylation of eukaryotic initiation factor-2 (eIF2). European Journal of Biochemistry / Febs. 268: 3674-84. PMID 11432733 DOI: 10.1046/j.1432-1327.2001.02273.x  0.92
2001 Vattem KM, Staschke KA, Zhu S, Wek RC. Inhibitory sequences in the N-terminus of the double-stranded-RNA-dependent protein kinase, PKR, are important for regulating phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha). European Journal of Biochemistry / Febs. 268: 1143-53. PMID 11179981 DOI: 10.1046/j.1432-1327.2001.01979.x  0.92
2001 Kimball SR, Clemens MJ, Tilleray VJ, Wek RC, Horetsky RL, Jefferson LS. The double-stranded RNA-activated protein kinase PKR is dispensable for regulation of translation initiation in response to either calcium mobilization from the endoplasmic reticulum or essential amino acid starvation Biochemical and Biophysical Research Communications. 280: 293-300. PMID 11162513 DOI: 10.1006/bbrc.2000.4103  0.92
2000 Yang R, Wek SA, Wek RC. Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinase. Molecular and Cellular Biology. 20: 2706-17. PMID 10733573 DOI: 10.1128/MCB.20.8.2706-2717.2000  0.92
2000 Sood R, Porter AC, Ma K, Quilliam LA, Wek RC. Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress. The Biochemical Journal. 346: 281-93. PMID 10677345 DOI: 10.1042/0264-6021:3460281  0.92
2000 Sood R, Porter AC, Olsen DA, Cavener DR, Wek RC. A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha. Genetics. 154: 787-801. PMID 10655230  0.92
1998 Shi Y, Vattem KM, Sood R, An J, Liang J, Stramm L, Wek RC. Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control. Molecular and Cellular Biology. 18: 7499-509. PMID 9819435  0.92
1998 Yang R, Chun KT, Wek RC. Mitochondrial respiratory mutants in yeast inhibit glycogen accumulation by blocking activation of glycogen synthase. The Journal of Biological Chemistry. 273: 31337-44. PMID 9813042 DOI: 10.1074/jbc.273.47.31337  0.92
1998 Olsen DS, Jordan B, Chen D, Wek RC, Cavener DR. Isolation of the gene encoding the Drosophila melanogaster homolog of the Saccharomyces cerevisiae GCN2 eIF-2alpha kinase. Genetics. 149: 1495-509. PMID 9649537  0.92
1998 Zhu S, Wek RC. Ribosome-binding domain of eukaryotic initiation factor-2 kinase GCN2 facilitates translation control Journal of Biological Chemistry. 273: 1808-1814. PMID 9430731 DOI: 10.1074/jbc.273.3.1808  0.92
1997 Zhu S, Romano PR, Wek RC. Ribosome targeting of PKR is mediated by two double-stranded RNA- binding domains and facilitates in vivo phosphorylation of eukaryotic initiation factor-2 Journal of Biological Chemistry. 272: 14434-14441. PMID 9162083 DOI: 10.1074/jbc.272.22.14434  0.92
1997 Sood R, Wek RC. GCN2, an eIF-2a protein kinase containing sequences related to aminoacyl-trna synthetases, is conserved from yeast to mammals Faseb Journal. 11.  0.92
1996 Zhu S, Sobolev AY, Wek RC. Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2 Journal of Biological Chemistry. 271: 24989-24994. PMID 8798780 DOI: 10.1074/jbc.271.40.24989  0.92
1996 Qian W, Zhu S, Sobolev AY, Wek RC. Expression of vaccinia virus K3L protein in yeast inhibits eukaryotic initiation factor-2 kinase GCN2 and the general amino acid control pathway Journal of Biological Chemistry. 271: 13202-13207. PMID 8662715 DOI: 10.1074/jbc.271.22.13202  0.92
1996 Zhu S, Sobolov A, Wek RC. Ribosome targeting of eIF-2 protein kinases, GCN2 and PKR Faseb Journal. 10: A1267.  0.92
1995 Wek SA, Zhu S, Wek RC. The histidyl-tRNA synthetase-related sequence in the eIF-2α protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids Molecular and Cellular Biology. 15: 4497-4506. PMID 7623840  0.92
1994 Vazquez De Aldana CR, Wek RC, San Segundo P, Truesdell AG, Hinnebusch AG. Multicopy tRNA genes functionally suppress mutations in yeast eIF-2α kinase GCN2: Evidence for separate pathways coupling GCN4 expression to uncharged tRNA Molecular and Cellular Biology. 14: 7920-7932. PMID 7969132  0.92
1994 Wek RC. elF-2 kinases: regulators of general and gene-specific translation initiation Trends in Biochemical Sciences. 19: 491-496. PMID 7855893 DOI: 10.1016/0968-0004(94)90136-8  0.92
1992 Dever TE, Feng L, Wek RC, Cigan AM, Donahue TF, Hinnebusch AG. Phosphorylation of initiation factor 2α by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast Cell. 68: 585-596. PMID 1739968 DOI: 10.1016/0092-8674(92)90193-G  0.92
1992 Ramirez M, Wek RC, Vazquez De Aldana CR, Jackson BM, Freeman B, Hinnebusch AG. Mutations activating the yeast eIF-2α kinase GCN2: Isolation of alleles altering the domain related to histidyl-tRNA synthetases Molecular and Cellular Biology. 12: 5801-5815. PMID 1448107  0.92
1992 Wek RC, Cannon JF, Dever TE, Hinnebusch AG. Truncated protein phosphatase GLC7 restores translational activation of GCN4 expression in yeast mutants defective for the eIF-2α kinase GCN2 Molecular and Cellular Biology. 12: 5700-5710. PMID 1333044  0.92
1991 Ramirez M, Wek RC, Hinnebusch AG. Ribosome Association of GCN2 Protein Kinase, a Translational Activator of the GCN4 Gene of Saccharomyces cerevisiae Molecular and Cellular Biology. 11: 3027-3036. PMID 2038314  0.92
1990 Hannig EM, Williams NP, Wek RC, Hinnebusch AG. The translational activator GCN3 functions downstream from GCN1 and GCN2 in the regulatory pathway that couples GCN4 expression to amino acid availability in Saccharomyces cerevisiae. Genetics. 126: 549-62. PMID 2249755  0.92
1990 Wek RC, Ramirez M, Jackson BM, Hinnebusch AG. Identification of Positive-Acting Domains in GCN2 Protein Kinase Required for Translational Activation of GCN4 Expression Molecular and Cellular Biology. 10: 2820-2831. PMID 2188100  0.92
1989 Wek RC, Jackson BM, Hinnebusch AG. Juxtaposition of domains homologous to protein kinase and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability Proceedings of the National Academy of Sciences of the United States of America. 86: 4579-4583. PMID 2660141  0.92
1989 Sameshima JH, Wek RC, Hatfield GW. Overlapping transcription and termination of the convergent ilvA and ilvY genes of Escherichia coli. The Journal of Biological Chemistry. 264: 1224-31. PMID 2642900  0.92
1988 Wek RC, Hatfield GW. Transcriptional activation at adjacent operators in the divergent-overlapping ilvY and ilvC promoters of Escherichia coli. Journal of Molecular Biology. 203: 643-63. PMID 3062177 DOI: 10.1016/0022-2836(88)90199-4  0.92
1988 Lawther RP, Wek RC, Lopes JM, Pereira R, Taillon BE, Hatfield GW. The complete nucteotide sequence of tbe ilvGMEDA operon of Escherichia coli k-12 Nucleic Acids Research. 16: 3602. DOI: 10.1093/nar/16.8.3602  0.92
1987 Lawther RP, Wek RC, Lopes JM, Pereira R, Taillon BE, Hatfield GW. The complete nucleotide sequence of the ilvGMEDA operon of Escherichia coli K-12. Nucleic Acids Research. 15: 2137-55. PMID 3550695 DOI: 10.1093/nar/15.5.2137  0.92
1987 Wek RC, Sameshima JH, Hatfield GW. Rho-dependent transcriptional polarity in the ilvGMEDA operon of wild-type Escherichia coli K12. The Journal of Biological Chemistry. 262: 15256-61. PMID 2822718  0.92
1986 Wek RC, Hatfield GW. Nucleotide sequence and in vivo expression of the ilvY and ilvC genes in Escherichia coli K12. Transcription from divergent overlapping promoters. The Journal of Biological Chemistry. 261: 2441-50. PMID 3003115  0.92
1986 Wek RC, Hatfield GW. Examination of the internal promoter, PE, in the ilvGMEDA operon of E. coli K-12. Nucleic Acids Research. 14: 2763-77. PMID 2421252 DOI: 10.1093/nar/14.6.2763  0.92
1985 Wek RC, Hauser CA, Hatfield GW. The nucleotide sequence of the ilvBN operon of Escherichia coli: Sequence homologies of the acetohydroxy acid synthase isozymes Nucleic Acids Research. 13: 3995-4010. PMID 2989782 DOI: 10.1093/nar/13.11.3995  0.92
1980 Sugino WM, Wek RC, Kingsbury DT. Partial nucleotide sequence similarity within species of Mycoplasma and Acholeplasma Journal of General Microbiology. 121: 333-338. PMID 7264601  0.92
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