Bryan Mackenzie, PhD - Publications

Molecular & Cellular Physiology University of Cincinnati, Cincinnati, OH 
Iron Metabolism

51 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Azucenas CR, Ruwe TA, Bonamer JP, Qiao B, Ganz T, Jormakka M, Nemeth E, Mackenzie B. Comparative analysis of the functional properties of human and mouse ferroportin. American Journal of Physiology. Cell Physiology. PMID 36939203 DOI: 10.1152/ajpcell.00063.2023  0.605
2020 Deshpande CN, Azucenas CR, Qiao B, Nomura N, Xin V, Font J, Iwata S, Ganz T, Nemeth E, Mackenzie B, Jormakka M. Isolation and thermal stabilization of mouse ferroportin. Febs Open Bio. PMID 33190422 DOI: 10.1002/2211-5463.13039  0.618
2020 Azucenas CR, Shawki A, Logeman BL, Niespodzany EJ, Dunham JL, Ruwe TA, Thiele DJ, Mackenzie B. Iron and copper transport activities of the mammalian metal‐ion transporters DMT1 and CTR1 The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.06793  0.774
2020 Ruwe TA, Qiao B, Bonamer JP, Azucenas CR, Ganz T, Nemeth E, Mackenzie B. Hepcidin inhibits ferroportin in the Xenopus oocyte expression system via a calcium‐dependent mechanism that does not involve endocytosis The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.04800  0.501
2018 Deshpande CN, Ruwe TA, Shawki A, Xin V, Vieth KR, Valore EV, Qiao B, Ganz T, Nemeth E, Mackenzie B, Jormakka M. Calcium is an essential cofactor for metal efflux by the ferroportin transporter family. Nature Communications. 9: 3075. PMID 30082682 DOI: 10.1038/S41467-018-05446-4  0.789
2017 Aschemeyer S, Qiao B, Stefanova D, Valore EV, Sek AC, Ruwe TA, Vieth KR, Jung G, Casu C, Rivella S, Jormakka M, Mackenzie B, Ganz T, Nemeth E. Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin. Blood. PMID 29237594 DOI: 10.1182/Blood-2017-05-786590  0.611
2016 Shawki A, Engevik MA, Kim RS, Knight PB, Baik RA, Anthony SR, Worrell RT, Shull GE, Mackenzie B. Intestinal brush-border Na+/H+ exchanger-3 drives H+-coupled iron absorption in the mouse. American Journal of Physiology. Gastrointestinal and Liver Physiology. ajpgi.00167.2016. PMID 27390324 DOI: 10.1152/Ajpgi.00167.2016  0.755
2015 Shawki A, Anthony SR, Nose Y, Engevik MA, Niespodzany EJ, Barrientos T, Öhrvik H, Worrell RT, Thiele DJ, Mackenzie B. Intestinal DMT1 is critical for iron absorption in the mouse but is not required for the absorption of copper or manganese. American Journal of Physiology. Gastrointestinal and Liver Physiology. 309: G635-47. PMID 26294671 DOI: 10.1152/Ajpgi.00160.2015  0.761
2015 Carvalho S, Barreira da Silva R, Shawki A, Castro H, Lamy M, Eide D, Costa V, Mackenzie B, Tomás AM. LiZIP3 is a cellular zinc transporter that mediates the tightly regulated import of zinc in Leishmania infantum parasites. Molecular Microbiology. 96: 581-95. PMID 25644708 DOI: 10.1111/Mmi.12957  0.753
2015 Shawki A, Ruwe TA, Mitchell C, Prakash S, Nemeth E, Ganz T, Mackenzie B. Ferroportin-mediated cellular iron efflux requires extracellular calcium The Faseb Journal. 29. DOI: 10.1096/Fasebj.29.1_Supplement.566.15  0.779
2014 Mitchell CJ, Shawki A, Ganz T, Nemeth E, Mackenzie B. Functional properties of human ferroportin, a cellular iron exporter reactive also with cobalt and zinc. American Journal of Physiology. Cell Physiology. 306: C450-9. PMID 24304836 DOI: 10.1152/Ajpcell.00348.2013  0.793
2012 Shawki A, Knight PB, Maliken BD, Niespodzany EJ, Mackenzie B. H(+)-coupled divalent metal-ion transporter-1: functional properties, physiological roles and therapeutics. Current Topics in Membranes. 70: 169-214. PMID 23177986 DOI: 10.1016/B978-0-12-394316-3.00005-3  0.801
2012 Wang CY, Jenkitkasemwong S, Duarte S, Sparkman BK, Shawki A, Mackenzie B, Knutson MD. ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading. The Journal of Biological Chemistry. 287: 34032-43. PMID 22898811 DOI: 10.1074/Jbc.M112.367284  0.792
2012 Illing AC, Shawki A, Cunningham CL, Mackenzie B. Substrate profile and metal-ion selectivity of human divalent metal-ion transporter-1. The Journal of Biological Chemistry. 287: 30485-96. PMID 22736759 DOI: 10.1074/Jbc.M112.364208  0.783
2012 Jenkitkasemwong S, Wang CY, Mackenzie B, Knutson MD. Physiologic implications of metal-ion transport by ZIP14 and ZIP8. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. 25: 643-55. PMID 22318508 DOI: 10.1007/S10534-012-9526-X  0.548
2011 Pinilla-Tenas JJ, Sparkman BK, Shawki A, Illing AC, Mitchell CJ, Zhao N, Liuzzi JP, Cousins RJ, Knutson MD, Mackenzie B. Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron. American Journal of Physiology. Cell Physiology. 301: C862-71. PMID 21653899 DOI: 10.1152/Ajpcell.00479.2010  0.791
2010 Mackenzie B, Shawki A, Ghio AJ, Stonehuerner JD, Zhao L, Ghadersohi S, Garrick LM, Garrick MD. Calcium-channel blockers do not affect iron transport mediated by divalent metal-ion transporter-1. Blood. 115: 4148-9. PMID 20489062 DOI: 10.1182/Blood-2010-03-274738  0.762
2010 Shawki A, Mackenzie B. Interaction of calcium with the human divalent metal-ion transporter-1. Biochemical and Biophysical Research Communications. 393: 471-5. PMID 20152801 DOI: 10.1016/J.Bbrc.2010.02.025  0.775
2009 Li HC, Collier JH, Shawki A, Rudra JS, Li EY, Mackenzie B, Soleimani M. Sequence- or position-specific mutations in the carboxyl-terminal FL motif of the kidney sodium bicarbonate cotransporter (NBC1) disrupt its basolateral targeting and alpha-helical structure. The Journal of Membrane Biology. 228: 111-24. PMID 19294449 DOI: 10.1007/S00232-009-9164-6  0.672
2009 Grewal S, Defamie N, Zhang X, De Gois S, Shawki A, Mackenzie B, Chen C, Varoqui H, Erickson JD. SNAT2 amino acid transporter is regulated by amino acids of the SLC6 gamma-aminobutyric acid transporter subfamily in neocortical neurons and may play no role in delivering glutamine for glutamatergic transmission. The Journal of Biological Chemistry. 284: 11224-36. PMID 19240036 DOI: 10.1074/Jbc.M806470200  0.707
2008 Mackenzie B, Illing AC, Hediger MA. Transport model of the human Na+-coupled L-ascorbic acid (vitamin C) transporter SVCT1. American Journal of Physiology. Cell Physiology. 294: C451-9. PMID 18094143 DOI: 10.1152/Ajpcell.00439.2007  0.625
2008 Mackenzie B, Illing AC, Morris ME, Varoqui H, Erickson JD. Analysis of a vesicular glutamate transporter (VGLUT2) supports a cell-leakage mode in addition to vesicular packaging. Neurochemical Research. 33: 238-47. PMID 18080752 DOI: 10.1007/S11064-007-9546-Z  0.404
2008 Mackenzie B, Hediger MA, Varoqui H. Mechanisms of the system a neuronal glutamine transporter SAT1 Journal of Neurochemistry. 81: 72-72. DOI: 10.1046/J.1471-4159.2002.00073.X  0.631
2008 Li HC, Shawki A, Park Y, Li EY, Hahm K, Collier JH, Mackenzie B, Soleimani M. Constraints of FL Motif on the Targeting and Function of Sodium-Bicarbonate Cotransporter 1 Nature Precedings. DOI: 10.1038/Npre.2008.1638.1  0.648
2007 Mackenzie B, Takanaga H, Hubert N, Rolfs A, Hediger MA. Functional properties of multiple isoforms of human divalent metal-ion transporter 1 (DMT1). The Biochemical Journal. 403: 59-69. PMID 17109629 DOI: 10.1042/Bj20061290  0.709
2006 Mackenzie B, Ujwal ML, Chang MH, Romero MF, Hediger MA. Divalent metal-ion transporter DMT1 mediates both H+ -coupled Fe2+ transport and uncoupled fluxes. Pflã¼Gers Archiv : European Journal of Physiology. 451: 544-58. PMID 16091957 DOI: 10.1007/S00424-005-1494-3  0.687
2005 Mackenzie B, Garrick MD. Iron Imports. II. Iron uptake at the apical membrane in the intestine. American Journal of Physiology. Gastrointestinal and Liver Physiology. 289: G981-6. PMID 16286504 DOI: 10.1152/Ajpgi.00363.2005  0.575
2005 Takanaga H, Mackenzie B, Peng JB, Hediger MA. Characterization of a branched-chain amino-acid transporter SBAT1 (SLC6A15) that is expressed in human brain. Biochemical and Biophysical Research Communications. 337: 892-900. PMID 16226721 DOI: 10.1016/J.Bbrc.2005.09.128  0.615
2005 Takanaga H, Mackenzie B, Suzuki Y, Hediger MA. Identification of mammalian proline transporter SIT1 (SLC6A20) with characteristics of classical system imino. The Journal of Biological Chemistry. 280: 8974-84. PMID 15632147 DOI: 10.1074/Jbc.M413027200  0.663
2004 Mackenzie B, Hediger MA. SLC11 family of H+-coupled metal-ion transporters NRAMP1 and DMT1. Pflã¼Gers Archiv : European Journal of Physiology. 447: 571-9. PMID 14530973 DOI: 10.1007/S00424-003-1141-9  0.689
2004 Mackenzie B, Erickson JD. Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family. Pflã¼Gers Archiv : European Journal of Physiology. 447: 784-95. PMID 12845534 DOI: 10.1007/S00424-003-1117-9  0.446
2004 Takanaga H, Mackenzie B, Hediger MA. Sodium-dependent ascorbic acid transporter family SLC23. Pflã¼Gers Archiv : European Journal of Physiology. 447: 677-82. PMID 12845532 DOI: 10.1007/S00424-003-1104-1  0.618
2003 Mackenzie B, Schäfer MK, Erickson JD, Hediger MA, Weihe E, Varoqui H. Functional properties and cellular distribution of the system A glutamine transporter SNAT1 support specialized roles in central neurons. The Journal of Biological Chemistry. 278: 23720-30. PMID 12684517 DOI: 10.1074/Jbc.M212718200  0.636
2000 Yao D, Mackenzie B, Ming H, Varoqui H, Zhu H, Hediger MA, Erickson JD. A novel system A isoform mediating Na+/neutral amino acid cotransport. The Journal of Biological Chemistry. 275: 22790-7. PMID 10811809 DOI: 10.1074/Jbc.M002965200  0.628
2000 Wang Y, Mackenzie B, Tsukaguchi H, Weremowicz S, Morton CC, Hediger MA. Human vitamin C (L-ascorbic acid) transporter SVCT1. Biochemical and Biophysical Research Communications. 267: 488-94. PMID 10631088 DOI: 10.1006/Bbrc.1999.1929  0.61
1999 Tsukaguchi H, Tokui T, Mackenzie B, Berger UV, Chen XZ, Wang Y, Brubaker RF, Hediger MA. A family of mammalian Na+-dependent L-ascorbic acid transporters. Nature. 399: 70-5. PMID 10331392 DOI: 10.1038/19986  0.656
1998 Tsukaguchi H, Shayakul C, Berger UV, Mackenzie B, Devidas S, Guggino WB, van Hoek AN, Hediger MA. Molecular characterization of a broad selectivity neutral solute channel. The Journal of Biological Chemistry. 273: 24737-43. PMID 9733774 DOI: 10.1074/Jbc.273.38.24737  0.3
1998 Mackenzie B, Loo DD, Wright EM. Relationships between Na+/glucose cotransporter (SGLT1) currents and fluxes. The Journal of Membrane Biology. 162: 101-6. PMID 9538503 DOI: 10.1007/S002329900347  0.512
1998 Mackenzie B, Tokui T, Berger UV, Tsukaguchi H, Chen XZ, Wang Y, Hediger MA. Characteristics of a novel epithelial Na+-coupled L-ascorbic acid transporter Faseb Journal. 12: A1016.  0.308
1997 Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, Nussberger S, Gollan JL, Hediger MA. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature. 388: 482-8. PMID 9242408 DOI: 10.1038/41343  0.67
1997 Ganapathy ME, Prasad PD, Mackenzie B, Ganapathy V, Leibach FH. Interaction of anionic cephalosporins with the intestinal and renal peptide transporters PEPT 1 and PEPT 2. Biochimica Et Biophysica Acta. 1324: 296-308. PMID 9092716 DOI: 10.1016/S0005-2736(96)00234-9  0.415
1997 Gunshin H, Gunshin Y, Bereer U, Nussberger S, Mackenzie B, Gollan JL, Hediger MA. Expression cloning of an iron transporter (IDCT1) in rat duodenum Faseb Journal. 11: A453.  0.422
1996 Mackenzie B, Loo DD, Panayotova-Heiermann M, Wright EM. Biophysical characteristics of the pig kidney Na+/glucose cotransporter SGLT2 reveal a common mechanism for SGLT1 and SGLT2. The Journal of Biological Chemistry. 271: 32678-83. PMID 8955098 DOI: 10.1074/Jbc.271.51.32678  0.542
1996 Mackenzie B, Fei YJ, Ganapathy V, Leibach FH. The human intestinal H+/oligopeptide cotransporter hPEPT1 transports differently-charged dipeptides with identical electrogenic properties. Biochimica Et Biophysica Acta. 1284: 125-8. PMID 8914574 DOI: 10.1016/S0005-2736(96)00170-8  0.43
1996 Taylor PM, Kaur S, Mackenzie B, Peter GJ. Amino-acid-dependent modulation of amino acid transport in Xenopus laevis oocytes. The Journal of Experimental Biology. 199: 923-31. PMID 8788089  0.314
1996 Mackenzie B, Loo DD, Fei Y, Liu WJ, Ganapathy V, Leibach FH, Wright EM. Mechanisms of the human intestinal H+-coupled oligopeptide transporter hPEPT1. The Journal of Biological Chemistry. 271: 5430-7. PMID 8621398 DOI: 10.1074/Jbc.271.10.5430  0.541
1994 Mackenzie B, Harper AA, Taylor PM, Rennie MJ. Na+/amino acid coupling stoichiometry of rheogenic system B0,+ transport in Xenopus oocytes is variable. Pflã¼Gers Archiv : European Journal of Physiology. 426: 121-8. PMID 8146015 DOI: 10.1007/Bf00374679  0.438
1994 Mackenzie B, Panayotova-Heiermann M, Loo DD, Lever JE, Wright EM. SAAT1 is a low affinity Na+/glucose cotransporter and not an amino acid transporter. A reinterpretation. The Journal of Biological Chemistry. 269: 22488-91. PMID 8077195  0.483
1994 Wright EM, Loo DD, Panayotova-Heiermann M, Lostao MP, Hirayama BH, Mackenzie B, Boorer K, Zampighi G. 'Active' sugar transport in eukaryotes. The Journal of Experimental Biology. 196: 197-212. PMID 7823022  0.536
1992 Taylor PM, Mackenzie B, Hundal HS, Robertson E, Rennie MJ. Transport and membrane binding of the glutamine analogue 6-diazo-5-oxo-L-norleucine (DON) in Xenopus laevis oocytes. The Journal of Membrane Biology. 128: 181-91. PMID 1501246 DOI: 10.1007/Bf00231811  0.456
1990 Hundal HS, Mackenzie B, Taylor PM, Rennie MJ. Uptake of glutamine in Xenopus oocytes: inhibition by 6-diazo-5-oxo-L-norleucine and harmaline. Biochemical Society Transactions. 18: 944-5. PMID 2083754 DOI: 10.1042/Bst0180944  0.309
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