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Matthew G. Guenther, Ph.D. - Publications

Affiliations: 
2001 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Molecular Biology, Genetics
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44 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Lambert AW, Fiore C, Chutake Y, Verhaar ER, Strasser PC, Chen MW, Farouq D, Das S, Li X, Eaton EN, Zhang Y, Liu Donaher J, Engstrom I, Reinhardt F, Yuan B, ... ... Guenther MG, et al. ΔNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells. Developmental Cell. 57: 2714-2730.e8. PMID 36538894 DOI: 10.1016/j.devcel.2022.11.015  0.345
2020 Lambert A, Fiore C, Chutake Y, Verhaar E, Chen MW, Donaher J, Reinhardt F, Engstrom I, Yuan B, Bierie B, Farouq D, Carulli J, Olson E, Guenther M, Weinberg R. Abstract P4-04-02: Epigenomic analysis of cancer stem cells (CSCs) from triple-negative breast cancer (TNBC) reveals p63 and p73 as core metastasis drivers Cancer Research. 80. DOI: 10.1158/1538-7445.Sabcs19-P4-04-02  0.401
2019 Beaulieu ME, Jauset T, Massó-Vallés D, Martínez-Martín S, Rahl P, Maltais L, Zacarias-Fluck MF, Casacuberta-Serra S, Serrano Del Pozo E, Fiore C, Foradada L, Cano VC, Sánchez-Hervás M, Guenther M, Romero Sanz E, et al. Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy. Science Translational Medicine. 11. PMID 30894502 DOI: 10.1126/Scitranslmed.Aar5012  0.363
2018 Guenther M, Lambert A, Chen M, Fiore C, Eaton M, Orlando D, Bierie B, Weinberg R, Fritz C, Olson E. Abstract P2-04-03: Epigenomic analysis of cancer stem cell (CSC)-enriched triple-negative breast cancer (TNBC) populations reveals gene regulatory circuitry and novel tumor cell vulnerabilities Cancer Research. 78. DOI: 10.1158/1538-7445.Sabcs17-P2-04-03  0.461
2018 Beaulieu M, Jauset T, Massó-Vallés D, Martínez-Martín S, Rahl P, Maltais L, Zacarias-Fluck MF, Casacuberta-Serra S, Pozo ESd, Fiore C, Foradada L, Cano VC, Guenther M, Sanza ER, Oteo M, et al. Abstract 3956: Omomyc-based cell-penetrating peptides: From proof of concept to a clinically viable anti-Myc therapy Cancer Research. 78: 3956-3956. DOI: 10.1158/1538-7445.Am2018-3956  0.334
2017 McKeown MR, Corces MR, Eaton ML, Fiore C, Lee E, Lopez JT, Chen MW, Smith D, Chan SM, Koenig JL, Austgen K, Guenther MG, Orlando DA, Lovén J, Fritz CC, et al. Super-Enhancer Analysis Defines Novel Epigenomic Subtypes of Non-APL AML Including an RARα Dependency Targetable by SY-1425, a Potent and Selective RARα Agonist. Cancer Discovery. PMID 28729405 DOI: 10.1158/2159-8290.Cd-17-0399  0.424
2017 Fiore CM, McKeown MR, Lee E, Eaton ML, Smith D, Austgen K, Chen MW, Guenther M, Corces MR, Majeti R, Olson E, Fritz CC. Abstract PR05: SY-1425 (tamibarotene), a potent and selective RARα agonist, induces changes in the transcriptional regulatory circuit of AML cells leading to differentiation Clinical Cancer Research. 23. DOI: 10.1158/1557-3265.Hemmal17-Pr05  0.483
2017 McKeown, Fiore C, Lee E, Eaton M, Orlando D, Guenther M, Collins C, Chen M, Fritz C, Tomaso Ed. Abstract P6-11-18: A novel subgroup of estrogen receptor positive breast cancer may benefit from super-enhancer guided patient selection for retinoic acid receptor α agonist treatment Cancer Research. 77. DOI: 10.1158/1538-7445.Sabcs16-P6-11-18  0.302
2017 Beaulieu M, Jauset T, Massó-Vallés D, Rahl P, Martinez-Martin S, Maltais L, Zacarias-Fluck MF, Casacuberta S, Pozo ESd, Fiore C, Foradada L, Guenther M, Sanz ER, Vives MO, Tremblay C, et al. Abstract 2167: Preclinical validation of an Omomyc cell-penetrating peptide as a viable anti-Myc therapy Cancer Research. 77: 2167-2167. DOI: 10.1158/1538-7445.Am2017-2167  0.364
2015 Orlando DA, McKeown MR, Chen MW, Collins C, Guenther MG, Fritz CC. Abstract A1-69: Predicting drug response by profiling the epigenome: Super-enhancers as biomarkers Cancer Research. 75. DOI: 10.1158/1538-7445.Transcagen-A1-69  0.342
2015 Guenther MG, Orlando DA, Eaton ML, Collins CA, Chen MW, Solanki S, Loven J, Fritz CC, Olson ER. Abstract P1-06-04: Super-enhancer analysis defines breast cancer subtype and identifies tumor dependencies Cancer Research. 75. DOI: 10.1158/1538-7445.Sabcs14-P1-06-04  0.394
2015 Collins C, Chen MW, Eaton M, Orlando D, McKeown M, Fritz C, Olson E, Guenther M. Abstract 3837: Super-enhancers define breast cancer subclasses and identify novel tumor cell vulnerabilities Cancer Research. 75: 3837-3837. DOI: 10.1158/1538-7445.Am2015-3837  0.397
2014 Orlando DA, Chen MW, Brown VE, Solanki S, Choi YJ, Olson ER, Fritz CC, Bradner JE, Guenther MG. Quantitative ChIP-Seq normalization reveals global modulation of the epigenome. Cell Reports. 9: 1163-70. PMID 25437568 DOI: 10.1016/J.Celrep.2014.10.018  0.418
2014 Anders L, Guenther MG, Qi J, Fan ZP, Marineau JJ, Rahl PB, Lovén J, Sigova AA, Smith WB, Lee TI, Bradner JE, Young RA. Genome-wide localization of small molecules. Nature Biotechnology. 32: 92-6. PMID 24336317 DOI: 10.1038/Nbt.2776  0.755
2014 Anders L, Guenther MG, Qi J, Fan ZP, Marineau JJ, Rahl PB, Lovén J, Sigova AA, Smith WB, Lee TI, Bradner JE, Young RA. Abstract 3230: Genome-wide localization of anti-cancer drugs Cancer Research. 74: 3230-3230. DOI: 10.1158/1538-7445.Am2014-3230  0.5
2014 Orlando DA, Chen MW, Brown VE, Solanki S, Choi YJ, Olson ER, Fritz CC, Bradner JE, Guenther MG. Quantitative ChIP-Seq normalization reveals global modulation of the epigenome Cell Reports. 9: 1163-1170. DOI: 10.1016/j.celrep.2014.10.018  0.306
2013 Sigova AA, Mullen AC, Molinie B, Gupta S, Orlando DA, Guenther MG, Almada AE, Lin C, Sharp PA, Giallourakis CC, Young RA. Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 2876-81. PMID 23382218 DOI: 10.1073/Pnas.1221904110  0.789
2012 Orlando DA, Guenther MG, Frampton GM, Young RA. CpG island structure and trithorax/polycomb chromatin domains in human cells. Genomics. 100: 320-6. PMID 22819920 DOI: 10.1016/J.Ygeno.2012.07.006  0.617
2012 Guenther MG, Young RA. Grounded: transcriptional pausing in naive mESCs. Cell Stem Cell. 10: 484-5. PMID 22560069 DOI: 10.1016/J.Stem.2012.04.016  0.589
2011 Guenther MG. Transcriptional control of embryonic and induced pluripotent stem cells. Epigenomics. 3: 323-43. PMID 22122341 DOI: 10.2217/Epi.11.15  0.62
2011 Mullen AC, Orlando DA, Newman JJ, Lovén J, Kumar RM, Bilodeau S, Reddy J, Guenther MG, DeKoter RP, Young RA. Master transcription factors determine cell-type-specific responses to TGF-β signaling. Cell. 147: 565-76. PMID 22036565 DOI: 10.1016/J.Cell.2011.08.050  0.755
2011 Golob JL, Kumar RM, Guenther MG, Pabon LM, Pratt GA, Loring JF, Laurent LC, Young RA, Murry CE. Evidence that gene activation and silencing during stem cell differentiation requires a transcriptionally paused intermediate state. Plos One. 6: e22416. PMID 21886766 DOI: 10.1371/Journal.Pone.0022416  0.658
2010 Guenther MG, Frampton GM, Soldner F, Hockemeyer D, Mitalipova M, Jaenisch R, Young RA. Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells. Cell Stem Cell. 7: 249-57. PMID 20682450 DOI: 10.1016/J.Stem.2010.06.015  0.652
2010 Guenther MG, Young RA. Transcription. Repressive transcription. Science (New York, N.Y.). 329: 150-1. PMID 20616255 DOI: 10.1126/Science.1193995  0.603
2010 Lengner CJ, Gimelbrant AA, Erwin JA, Cheng AW, Guenther MG, Welstead GG, Alagappan R, Frampton GM, Xu P, Muffat J, Santagata S, Powers D, Barrett CB, Young RA, Lee JT, et al. Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations. Cell. 141: 872-83. PMID 20471072 DOI: 10.1016/J.Cell.2010.04.010  0.55
2008 Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert TL, Croce CM, Nakamura T, Canaani E, Young RA. Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia. Genes & Development. 22: 3403-8. PMID 19141473 DOI: 10.1101/Gad.1741408  0.767
2008 Marson A, Levine SS, Cole MF, Frampton GM, Brambrink T, Johnstone S, Guenther MG, Johnston WK, Wernig M, Newman J, Calabrese JM, Dennis LM, Volkert TL, Gupta S, Love J, et al. Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell. 134: 521-33. PMID 18692474 DOI: 10.1016/J.Cell.2008.07.020  0.735
2007 Guenther MG, Levine SS, Boyer LA, Jaenisch R, Young RA. A chromatin landmark and transcription initiation at most promoters in human cells. Cell. 130: 77-88. PMID 17632057 DOI: 10.1016/J.Cell.2007.05.042  0.832
2006 Lee TI, Jenner RG, Boyer LA, Guenther MG, Levine SS, Kumar RM, Chevalier B, Johnstone SE, Cole MF, Isono K, Koseki H, Fuchikami T, Abe K, Murray HL, Zucker JP, et al. Control of developmental regulators by Polycomb in human embryonic stem cells. Cell. 125: 301-13. PMID 16630818 DOI: 10.1016/J.Cell.2006.02.043  0.789
2005 Boyer LA, Lee TI, Cole MF, Johnstone SE, Levine SS, Zucker JP, Guenther MG, Kumar RM, Murray HL, Jenner RG, Gifford DK, Melton DA, Jaenisch R, Young RA. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell. 122: 947-56. PMID 16153702 DOI: 10.1016/J.Cell.2005.08.020  0.787
2005 Guenther MG, Jenner RG, Chevalier B, Nakamura T, Croce CM, Canaani E, Young RA. Global and Hox-specific roles for the MLL1 methyltransferase. Proceedings of the National Academy of Sciences of the United States of America. 102: 8603-8. PMID 15941828 DOI: 10.1073/Pnas.0503072102  0.65
2003 Guenther MG, Lazar MA. Biochemical isolation and analysis of a nuclear receptor corepressor complex. Methods in Enzymology. 364: 246-57. PMID 14631849 DOI: 10.1016/S0076-6879(03)64014-0  0.564
2003 Yu J, Li Y, Ishizuka T, Guenther MG, Lazar MA. A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation. The Embo Journal. 22: 3403-10. PMID 12840002 DOI: 10.1093/Emboj/Cdg326  0.768
2003 Kao GD, McKenna WG, Guenther MG, Muschel RJ, Lazar MA, Yen TJ. Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response. The Journal of Cell Biology. 160: 1017-27. PMID 12668657 DOI: 10.1083/Jcb.200209065  0.537
2002 Guenther MG, Yu J, Kao GD, Yen TJ, Lazar MA. Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex. Genes & Development. 16: 3130-5. PMID 12502735 DOI: 10.1101/Gad.1037502  0.77
2002 Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E. Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Molecular Cell. 9: 45-57. PMID 11804585 DOI: 10.1016/S1097-2765(01)00429-4  0.606
2001 Guenther MG, Barak O, Lazar MA. The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3. Molecular and Cellular Biology. 21: 6091-101. PMID 11509652 DOI: 10.1128/Mcb.21.18.6091-6101.2001  0.599
2001 Phiel CJ, Zhang F, Huang EY, Guenther MG, Lazar MA, Klein PS. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. The Journal of Biological Chemistry. 276: 36734-41. PMID 11473107 DOI: 10.1074/Jbc.M101287200  0.552
2000 Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R. A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness. Genes & Development. 14: 1048-57. PMID 10809664  0.567
2000 Huang EY, Zhang J, Miska EA, Guenther MG, Kouzarides T, Lazar MA. Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway. Genes & Development. 14: 45-54. PMID 10640275  0.56
2000 Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R. A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness. Genes & Development. 14: 1048-1057. DOI: 10.1101/Gad.14.9.1048  0.612
2000 Huang EY, Zhang J, Miska EA, Guenther MG, Kouzarides T, Lazar MA. Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway Genes & Development. 14: 45-54. DOI: 10.1101/Gad.14.1.45  0.607
1999 Atkins GB, Hu X, Guenther MG, Rachez C, Freedman LP, Lazar MA. Coactivators for the orphan nuclear receptor RORalpha. Molecular Endocrinology (Baltimore, Md.). 13: 1550-7. PMID 10478845 DOI: 10.1210/Mend.13.9.0343  0.526
1998 Zhang J, Guenther MG, Carthew RW, Lazar MA. Proteasomal regulation of nuclear receptor corepressor-mediated repression. Genes & Development. 12: 1775-80. PMID 9637679 DOI: 10.1101/Gad.12.12.1775  0.644
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