Matthew G. Guenther, Ph.D. - Publications

2001 University of Pennsylvania, Philadelphia, PA, United States 
Molecular Biology, Genetics

30 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 McKeown MR, Corces MR, Eaton ML, Fiore C, Lee E, Lopez JT, Chen MW, Smith D, Chan SM, Koenig JL, Austgen K, Guenther MG, Orlando DA, Lovén J, Fritz CC, et al. Super-Enhancer Analysis Defines Novel Epigenomic Subtypes of Non-APL AML Including an RARα Dependency Targetable by SY-1425, a Potent and Selective RARα Agonist. Cancer Discovery. PMID 28729405 DOI: 10.1158/2159-8290.CD-17-0399  0.48
2014 Orlando DA, Chen MW, Brown VE, Solanki S, Choi YJ, Olson ER, Fritz CC, Bradner JE, Guenther MG. Quantitative ChIP-Seq normalization reveals global modulation of the epigenome. Cell Reports. 9: 1163-70. PMID 25437568 DOI: 10.1016/j.celrep.2014.10.018  0.48
2014 Anders L, Guenther MG, Qi J, Fan ZP, Marineau JJ, Rahl PB, Lovén J, Sigova AA, Smith WB, Lee TI, Bradner JE, Young RA. Genome-wide localization of small molecules. Nature Biotechnology. 32: 92-6. PMID 24336317 DOI: 10.1038/nbt.2776  0.76
2014 Orlando DA, Chen MW, Brown VE, Solanki S, Choi YJ, Olson ER, Fritz CC, Bradner JE, Guenther MG. Quantitative ChIP-Seq normalization reveals global modulation of the epigenome Cell Reports. 9: 1163-1170. DOI: 10.1016/j.celrep.2014.10.018  0.76
2013 Sigova AA, Mullen AC, Molinie B, Gupta S, Orlando DA, Guenther MG, Almada AE, Lin C, Sharp PA, Giallourakis CC, Young RA. Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 2876-81. PMID 23382218 DOI: 10.1073/pnas.1221904110  0.76
2012 Orlando DA, Guenther MG, Frampton GM, Young RA. CpG island structure and trithorax/polycomb chromatin domains in human cells. Genomics. 100: 320-6. PMID 22819920 DOI: 10.1016/j.ygeno.2012.07.006  0.76
2012 Guenther MG, Young RA. Grounded: transcriptional pausing in naive mESCs. Cell Stem Cell. 10: 484-5. PMID 22560069 DOI: 10.1016/j.stem.2012.04.016  0.76
2011 Guenther MG. Transcriptional control of embryonic and induced pluripotent stem cells. Epigenomics. 3: 323-43. PMID 22122341 DOI: 10.2217/epi.11.15  0.76
2011 Mullen AC, Orlando DA, Newman JJ, Lovén J, Kumar RM, Bilodeau S, Reddy J, Guenther MG, DeKoter RP, Young RA. Master transcription factors determine cell-type-specific responses to TGF-β signaling. Cell. 147: 565-76. PMID 22036565 DOI: 10.1016/j.cell.2011.08.050  0.76
2011 Golob JL, Kumar RM, Guenther MG, Pabon LM, Pratt GA, Loring JF, Laurent LC, Young RA, Murry CE. Evidence that gene activation and silencing during stem cell differentiation requires a transcriptionally paused intermediate state. Plos One. 6: e22416. PMID 21886766 DOI: 10.1371/journal.pone.0022416  0.76
2010 Guenther MG, Frampton GM, Soldner F, Hockemeyer D, Mitalipova M, Jaenisch R, Young RA. Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells. Cell Stem Cell. 7: 249-57. PMID 20682450 DOI: 10.1016/j.stem.2010.06.015  0.76
2010 Guenther MG, Young RA. Transcription. Repressive transcription. Science (New York, N.Y.). 329: 150-1. PMID 20616255 DOI: 10.1126/science.1193995  0.76
2010 Lengner CJ, Gimelbrant AA, Erwin JA, Cheng AW, Guenther MG, Welstead GG, Alagappan R, Frampton GM, Xu P, Muffat J, Santagata S, Powers D, Barrett CB, Young RA, Lee JT, et al. Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations. Cell. 141: 872-83. PMID 20471072 DOI: 10.1016/j.cell.2010.04.010  0.76
2008 Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert TL, Croce CM, Nakamura T, Canaani E, Young RA. Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia. Genes & Development. 22: 3403-8. PMID 19141473 DOI: 10.1101/gad.1741408  0.76
2008 Marson A, Levine SS, Cole MF, Frampton GM, Brambrink T, Johnstone S, Guenther MG, Johnston WK, Wernig M, Newman J, Calabrese JM, Dennis LM, Volkert TL, Gupta S, Love J, et al. Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell. 134: 521-33. PMID 18692474 DOI: 10.1016/j.cell.2008.07.020  0.76
2007 Guenther MG, Levine SS, Boyer LA, Jaenisch R, Young RA. A chromatin landmark and transcription initiation at most promoters in human cells. Cell. 130: 77-88. PMID 17632057 DOI: 10.1016/j.cell.2007.05.042  0.76
2006 Lee TI, Jenner RG, Boyer LA, Guenther MG, Levine SS, Kumar RM, Chevalier B, Johnstone SE, Cole MF, Isono K, Koseki H, Fuchikami T, Abe K, Murray HL, Zucker JP, et al. Control of developmental regulators by Polycomb in human embryonic stem cells. Cell. 125: 301-13. PMID 16630818 DOI: 10.1016/j.cell.2006.02.043  0.76
2005 Boyer LA, Lee TI, Cole MF, Johnstone SE, Levine SS, Zucker JP, Guenther MG, Kumar RM, Murray HL, Jenner RG, Gifford DK, Melton DA, Jaenisch R, Young RA. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell. 122: 947-56. PMID 16153702 DOI: 10.1016/j.cell.2005.08.020  0.76
2005 Guenther MG, Jenner RG, Chevalier B, Nakamura T, Croce CM, Canaani E, Young RA. Global and Hox-specific roles for the MLL1 methyltransferase. Proceedings of the National Academy of Sciences of the United States of America. 102: 8603-8. PMID 15941828 DOI: 10.1073/pnas.0503072102  0.76
2003 Guenther MG, Lazar MA. Biochemical isolation and analysis of a nuclear receptor corepressor complex. Methods in Enzymology. 364: 246-57. PMID 14631849 DOI: 10.1016/S0076-6879(03)64014-0  0.76
2003 Yu J, Li Y, Ishizuka T, Guenther MG, Lazar MA. A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation. The Embo Journal. 22: 3403-10. PMID 12840002 DOI: 10.1093/emboj/cdg326  0.76
2003 Kao GD, McKenna WG, Guenther MG, Muschel RJ, Lazar MA, Yen TJ. Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response. The Journal of Cell Biology. 160: 1017-27. PMID 12668657 DOI: 10.1083/jcb.200209065  0.76
2002 Guenther MG, Yu J, Kao GD, Yen TJ, Lazar MA. Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex. Genes & Development. 16: 3130-5. PMID 12502735 DOI: 10.1101/gad.1037502  0.76
2002 Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E. Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Molecular Cell. 9: 45-57. PMID 11804585 DOI: 10.1016/S1097-2765(01)00429-4  0.76
2001 Guenther MG, Barak O, Lazar MA. The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3. Molecular and Cellular Biology. 21: 6091-101. PMID 11509652 DOI: 10.1128/MCB.21.18.6091-6101.2001  0.76
2001 Phiel CJ, Zhang F, Huang EY, Guenther MG, Lazar MA, Klein PS. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. The Journal of Biological Chemistry. 276: 36734-41. PMID 11473107 DOI: 10.1074/jbc.M101287200  0.76
2000 Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R. A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness. Genes & Development. 14: 1048-57. PMID 10809664  0.76
2000 Huang EY, Zhang J, Miska EA, Guenther MG, Kouzarides T, Lazar MA. Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway. Genes & Development. 14: 45-54. PMID 10640275  0.76
1999 Atkins GB, Hu X, Guenther MG, Rachez C, Freedman LP, Lazar MA. Coactivators for the orphan nuclear receptor RORalpha. Molecular Endocrinology (Baltimore, Md.). 13: 1550-7. PMID 10478845 DOI: 10.1210/mend.13.9.0343  0.76
1998 Zhang J, Guenther MG, Carthew RW, Lazar MA. Proteasomal regulation of nuclear receptor corepressor-mediated repression. Genes & Development. 12: 1775-80. PMID 9637679  0.76
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