Daniele M. Gilkes, Ph.D. - Publications

Affiliations: 
2008 University of South Florida, Tampa, FL, United States 
Area:
Oncology, Genetics, Microbiology Biology

62 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Wang R, Godet I, Yang Y, Salman S, Lu H, Lyu Y, Zuo Q, Wang Y, Zhu Y, Chen C, He J, Gilkes DM, Semenza GL. Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33952697 DOI: 10.1073/pnas.2020490118  1
2020 DiGiacomo JW, Godet I, Trautmann-Rodriguez M, Gilkes DM. Extracellular matrix-bound FGF2 mediates estrogen receptor signaling and therapeutic response in breast cancer. Molecular Cancer Research : McR. PMID 33033110 DOI: 10.1158/1541-7786.MCR-20-0554  0.01
2020 Mamo M, Ye IC, DiGiacomo JW, Park JY, Downs B, Gilkes DM. Hypoxia alters the response to anti-EGFR therapy by regulating EGFR expression and downstream signaling in a DNA methylation-specific and HIF-dependent manner. Cancer Research. PMID 33023947 DOI: 10.1158/0008-5472.CAN-20-1232  0.12
2020 Ju JA, Godet I, DiGiacomo JW, Gilkes DM. RhoB is regulated by hypoxia and modulates metastasis in breast cancer. Cancer Reports (Hoboken, N.J.). 3: e1164. PMID 32671953 DOI: 10.1002/cnr2.1164  1
2020 Wu PH, Gilkes DM, Phillip JM, Narkar A, Cheng TW, Marchand J, Lee MH, Li R, Wirtz D. Single-cell morphology encodes metastatic potential. Science Advances. 6: eaaw6938. PMID 32010778 DOI: 10.1126/Sciadv.Aaw6938  1
2019 Godet I, Shin YJ, Ju JA, Ye IC, Wang G, Gilkes DM. Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis. Nature Communications. 10: 4862. PMID 31649238 DOI: 10.1038/S41467-019-12412-1  1
2019 DiGiacomo JW, Gilkes DM. Therapeutic Strategies to Block the Hypoxic Response. Advances in Experimental Medicine and Biology. 1136: 141-157. PMID 31201722 DOI: 10.1007/978-3-030-12734-3_10  0.01
2019 Gilkes DM, Wirtz D. Solid Stress in Brain Tumors. Trends in Cancer. 5: 266-268. PMID 31174838 DOI: 10.1016/J.Trecan.2019.03.003  1
2019 Xiang L, Gilkes DM. The Contribution of the Immune System in Bone Metastasis Pathogenesis. International Journal of Molecular Sciences. 20. PMID 30823602 DOI: 10.3390/Ijms20040999  1
2019 Godet I, Shin YJ, Ju JA, Bhoyar S, Ye IC, Wang G, Sukumar S, Gilkes DM. Abstract 2649: A novel approach to fate-map hypoxic cells during tumor progression uncovers metastatic potency of post-hypoxic cells Cancer Research. 79: 2649-2649. DOI: 10.1158/1538-7445.Am2019-2649  1
2019 DiGiacomo JW, Godet I, Rodriguez MT, Ye IC, Gilkes DM. Abstract 1010: Extracellular matrix signaling modulates estrogen receptor activity in breast cancer Cancer Research. 79: 1010-1010. DOI: 10.1158/1538-7445.Am2019-1010  0.04
2018 Bhoyar S, Godet I, DiGiacomo JW, Gilkes DM. A software tool for the quantification of metastatic colony growth dynamics and size distributions in vitro and in vivo. Plos One. 13: e0209591. PMID 30589908 DOI: 10.1371/Journal.Pone.0209591  0.08
2018 Ye IC, Fertig EJ, DiGiacomo JW, Considine M, Godet I, Gilkes DM. Molecular Portrait of Hypoxia in Breast Cancer: A Prognostic Signature and Novel HIF-regulated Genes. Molecular Cancer Research : McR. PMID 30037853 DOI: 10.1158/1541-7786.Mcr-18-0345  0.08
2018 DiGiacomo JW, Gilkes DM. Tumor Hypoxia As an Enhancer of Inflammation-Mediated Metastasis: Emerging Therapeutic Strategies. Targeted Oncology. PMID 29423593 DOI: 10.1007/S11523-018-0555-4  0.01
2018 Belcher DA, Ju JA, Baek JH, Yalamanoglu A, Buehler PW, Gilkes DM, Palmer AF. The quaternary state of polymerized human hemoglobin regulates oxygenation of breast cancer solid tumors: A theoretical and experimental study. Plos One. 13: e0191275. PMID 29414985 DOI: 10.1371/Journal.Pone.0191275  1
2018 Ju JA, Gilkes DM. RhoB: Team Oncogene or Team Tumor Suppressor? Genes. 9. PMID 29385717 DOI: 10.3390/Genes9020067  1
2017 Phillip JM, Wu PH, Gilkes DM, Williams W, McGovern S, Daya J, Chen J, Aifuwa I, Lee JSH, Fan R, Walston J, Wirtz D. Biophysical and biomolecular determination of cellular age in humans. Nature Biomedical Engineering. 1. PMID 31372309 DOI: 10.1038/S41551-017-0093  1
2017 Jun JC, Rathore A, Younas H, Gilkes D, Polotsky VY. Hypoxia-Inducible Factors and Cancer. Current Sleep Medicine Reports. 3: 1-10. PMID 28944164 DOI: 10.1007/s40675-017-0062-7  0.08
2017 Godet I, Gilkes DM. BRCA1 and BRCA2 mutations and treatment strategies for breast cancer. Integrative Cancer Science and Therapeutics. 4. PMID 28706734 DOI: 10.15761/Icst.1000228  0.08
2017 Jayatilaka H, Tyle P, Chen JJ, Kwak M, Ju J, Kim HJ, Lee JSH, Wu PH, Gilkes DM, Fan R, Wirtz D. Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration. Nature Communications. 8: 15584. PMID 28548090 DOI: 10.1038/Ncomms15584  1
2017 Ju JA, Godet I, Ye IC, Byun J, Jayatilaka H, Lee SJ, Xiang L, Samanta D, Lee MH, Wu PH, Wirtz D, Semenza GL, Gilkes DM. Hypoxia Selectively Enhances Integrin Receptor Expression to Promote Metastasis. Molecular Cancer Research : McR. PMID 28213554 DOI: 10.1158/1541-7786.Mcr-16-0338  1
2016 Gilkes DM. Implications of Hypoxia in Breast Cancer Metastasis to Bone. International Journal of Molecular Sciences. 17. PMID 27706047 DOI: 10.3390/Ijms17101669  0.01
2016 Samanta D, Park Y, Andrabi SA, Shelton LM, Gilkes DM, Semenza GL. PHGDH Expression is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance and Lung Metastasis. Cancer Research. PMID 27280394 DOI: 10.1158/0008-5472.Can-16-0530  1
2015 Jimenez Valencia AM, Wu PH, Yogurtcu ON, Rao P, DiGiacomo J, Godet I, He L, Lee MH, Gilkes D, Sun SX, Wirtz D. Collective cancer cell invasion induced by coordinated contractile stresses. Oncotarget. PMID 26528856 DOI: 10.18632/Oncotarget.5874  1
2015 Zhang H, Lu H, Xiang L, Bullen JW, Zhang C, Samanta D, Gilkes DM, He J, Semenza GL. HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 26512116 DOI: 10.1073/Pnas.1520032112  1
2015 Lee MH, Wu PH, Gilkes D, Aifuwa I, Wirtz D. Normal mammary epithelial cells promote carcinoma basement membrane invasion by inducing microtubule-rich protrusions. Oncotarget. PMID 26334095 DOI: 10.18632/Oncotarget.4728  1
2015 Xiang L, Gilkes DM, Hu H, Luo W, Bullen JW, Liang H, Semenza GL. HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells. Oncotarget. 6: 11768-78. PMID 26059435 DOI: 10.18632/Oncotarget.4190  1
2014 Xiang L, Gilkes DM, Hu H, Takano N, Luo W, Lu H, Bullen JW, Samanta D, Liang H, Semenza GL. Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype. Oncotarget. 5: 12509-27. PMID 25587023 DOI: 10.18632/Oncotarget.2997  1
2014 Samanta D, Gilkes DM, Chaturvedi P, Xiang L, Semenza GL. Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells. Proceedings of the National Academy of Sciences of the United States of America. 111: E5429-38. PMID 25453096 DOI: 10.1073/Pnas.1421438111  1
2014 Hu H, Takano N, Xiang L, Gilkes DM, Luo W, Semenza GL. Hypoxia-inducible factors enhance glutamate signaling in cancer cells. Oncotarget. 5: 8853-68. PMID 25326682 DOI: 10.18632/Oncotarget.2593  1
2014 Hubbi ME, Gilkes DM, Hu H, Kshitiz, Ahmed I, Semenza GL. Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression. Proceedings of the National Academy of Sciences of the United States of America. 111: E3325-34. PMID 25071185 DOI: 10.1073/Pnas.1412840111  1
2014 Takano N, Sarfraz Y, Gilkes DM, Chaturvedi P, Xiang L, Suematsu M, Zagzag D, Semenza GL. Decreased expression of cystathionine β-synthase promotes glioma tumorigenesis. Molecular Cancer Research : McR. 12: 1398-406. PMID 24994751 DOI: 10.1158/1541-7786.Mcr-14-0184  1
2014 Wang T, Gilkes DM, Takano N, Xiang L, Luo W, Bishop CJ, Chaturvedi P, Green JJ, Semenza GL. Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis. Proceedings of the National Academy of Sciences of the United States of America. 111: E3234-42. PMID 24938788 DOI: 10.1073/Pnas.1410041111  1
2014 Gilkes DM, Semenza GL, Wirtz D. Hypoxia and the extracellular matrix: drivers of tumour metastasis. Nature Reviews. Cancer. 14: 430-9. PMID 24827502 DOI: 10.1038/Nrc3726  1
2014 Chaturvedi P, Gilkes DM, Takano N, Semenza GL. Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment. Proceedings of the National Academy of Sciences of the United States of America. 111: E2120-9. PMID 24799675 DOI: 10.1073/Pnas.1406655111  1
2014 Gilkes DM, Xiang L, Lee SJ, Chaturvedi P, Hubbi ME, Wirtz D, Semenza GL. Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 111: E384-93. PMID 24324133 DOI: 10.1073/Pnas.1321510111  1
2014 Xiang L, Gilkes DM, Chaturvedi P, Luo W, Hu H, Takano N, Liang H, Semenza GL. Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer. Journal of Molecular Medicine (Berlin, Germany). 92: 151-64. PMID 24248265 DOI: 10.1007/S00109-013-1102-5  1
2013 Gilkes DM, Semenza GL. Role of hypoxia-inducible factors in breast cancer metastasis. Future Oncology (London, England). 9: 1623-36. PMID 24156323 DOI: 10.2217/Fon.13.92  1
2013 Hubbi ME, Hu H, Kshitiz, Gilkes DM, Semenza GL. Sirtuin-7 inhibits the activity of hypoxia-inducible factors. The Journal of Biological Chemistry. 288: 20768-75. PMID 23750001 DOI: 10.1074/Jbc.M113.476903  1
2013 Gilkes DM, Chaturvedi P, Bajpai S, Wong CC, Wei H, Pitcairn S, Hubbi ME, Wirtz D, Semenza GL. Collagen prolyl hydroxylases are essential for breast cancer metastasis. Cancer Research. 73: 3285-96. PMID 23539444 DOI: 10.1158/0008-5472.Can-12-3963  1
2013 Gilkes DM, Bajpai S, Chaturvedi P, Wirtz D, Semenza GL. Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts. The Journal of Biological Chemistry. 288: 10819-29. PMID 23423382 DOI: 10.1074/Jbc.M112.442939  1
2013 Hubbi ME, Kshitiz, Gilkes DM, Rey S, Wong CC, Luo W, Kim DH, Dang CV, Levchenko A, Semenza GL. A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication Science Signaling. 6. PMID 23405012 DOI: 10.1126/Scisignal.2003417  1
2013 Gilkes DM, Bajpai S, Wong CC, Chaturvedi P, Hubbi ME, Wirtz D, Semenza GL. Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis. Molecular Cancer Research : McR. 11: 456-66. PMID 23378577 DOI: 10.1158/1541-7786.Mcr-12-0629  1
2013 Chaturvedi P, Gilkes DM, Wong CC, Luo W, Zhang H, Wei H, Takano N, Schito L, Levchenko A, Semenza GL. Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. The Journal of Clinical Investigation. 123: 189-205. PMID 23318994 DOI: 10.1172/Jci64993  1
2013 Chaturvedi P, Gilkes DM, Wong CCL, Kshitiz, Luo W, Zhang H, Wei H, Takano N, Schito L, Levchenko A, Semenza GL. Erratum: Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis (Journal of Clinical Investigation (2013) 123: 1 (189-205) DOI: 10.1172/JCI64993) Journal of Clinical Investigation. 123. DOI: 10.1172/Jci69244  1
2013 Gilkes DM, Chaturvedi P, Wong C, Bajpai S, Wei H, Hubbi M, Wirtz D, Semenza G. Abstract A3: Collagen hydroxylases are essential for breast cancer metastasis Cancer Research. 73. DOI: 10.1158/1538-7445.Tim2013-A3  1
2013 Chaturvedi P, Gilkes D, Semenza G. Abstract 505: Hypoxia inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. Cancer Research. 73: 505-505. DOI: 10.1158/1538-7445.Am2013-505  1
2013 Gilkes DM, Chaturvedi P, Bajpai S, Hubbi M, Wirtz D, Semenza G. Abstract 3937: Collagen prolyl hydroxylases are essential for breast cancer metastasis. Cancer Research. 73: 3937-3937. DOI: 10.1158/1538-7445.Am2013-3937  1
2012 Wong CC, Zhang H, Gilkes DM, Chen J, Wei H, Chaturvedi P, Hubbi ME, Semenza GL. Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis. Journal of Molecular Medicine (Berlin, Germany). 90: 803-15. PMID 22231744 DOI: 10.1007/S00109-011-0855-Y  1
2012 Hubbi ME, Gilkes DM, Baek JH, Semenza GL. Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1. The Journal of Biological Chemistry. 287: 6139-49. PMID 22219185 DOI: 10.1074/Jbc.M111.278630  1
2012 Li X, Gilkes D, Li B, Cheng Q, Pernazza D, Lawrence H, Lawrence N, Chen J. Abnormal MDMX degradation in tumor cells due to ARF deficiency. Oncogene. 31: 3721-32. PMID 22120712 DOI: 10.1038/Onc.2011.534  1
2012 Zhang H, Wong CC, Wei H, Gilkes DM, Korangath P, Chaturvedi P, Schito L, Chen J, Krishnamachary B, Winnard PT, Raman V, Zhen L, Mitzner WA, Sukumar S, Semenza GL. HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs. Oncogene. 31: 1757-70. PMID 21860410 DOI: 10.1038/Onc.2011.365  1
2011 Wong CC, Gilkes DM, Zhang H, Chen J, Wei H, Chaturvedi P, Fraley SI, Wong CM, Khoo US, Ng IO, Wirtz D, Semenza GL. Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Proceedings of the National Academy of Sciences of the United States of America. 108: 16369-74. PMID 21911388 DOI: 10.1073/Pnas.1113483108  1
2011 Wong CCL, Gilkes D, Zhang H, Chen J, Chaturvedi P, Fraley S, Semenza GL. Abstract 1521: Hypoxia inducible factor is an important regulator of metastatic niche formation Cancer Research. 71: 1521-1521. DOI: 10.1158/1538-7445.Am2011-1521  1
2008 Gilkes DM, Pan Y, Coppola D, Yeatman T, Reuther GW, Chen J. Regulation of MDMX expression by mitogenic signaling. Molecular and Cellular Biology. 28: 1999-2010. PMID 18172009 DOI: 10.1128/Mcb.01633-07  1
2007 Hu B, Gilkes DM, Chen J. Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX. Cancer Research. 67: 8810-7. PMID 17875722 DOI: 10.1158/0008-5472.Can-07-1140  1
2007 Gilkes DM, Chen J. Distinct roles of MDMX in the regulation of p53 response to ribosomal stress. Cell Cycle (Georgetown, Tex.). 6: 151-5. PMID 17327702 DOI: 10.4161/Cc.6.2.3719  1
2006 Gilkes DM, Chen L, Chen J. MDMX regulation of p53 response to ribosomal stress. The Embo Journal. 25: 5614-25. PMID 17110929 DOI: 10.1038/Sj.Emboj.7601424  1
2006 Hu B, Gilkes DM, Farooqi B, Sebti SM, Chen J. MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin. The Journal of Biological Chemistry. 281: 33030-5. PMID 16905541 DOI: 10.1074/Jbc.C600147200  1
2006 LeBron C, Chen L, Gilkes DM, Chen J. Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3. The Embo Journal. 25: 1196-206. PMID 16511560 DOI: 10.1038/Sj.Emboj.7601032  1
2005 Nefedova Y, Cheng P, Gilkes D, Blaskovich M, Beg AA, Sebti SM, Gabrilovich DI. Activation of dendritic cells via inhibition of Jak2/STAT3 signaling. Journal of Immunology (Baltimore, Md. : 1950). 175: 4338-46. PMID 16177074 DOI: 10.4049/Jimmunol.175.7.4338  1
2005 Chen L, Gilkes DM, Pan Y, Lane WS, Chen J. ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. The Embo Journal. 24: 3411-22. PMID 16163388 DOI: 10.1038/Sj.Emboj.7600812  1
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