Lizbeth Hedstrom - Publications

Affiliations: 
Molecular and Cell Biology Brandeis University, Waltham, MA, United States 
Area:
Molecular Biology, Pathology

127 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Chacko S, Boshoff HIM, Singh V, Ferraris DM, Gollapalli DR, Zhang M, Lawson AP, Pepi MJ, Joachimiak A, Rizzi M, Mizrahi V, Cuny GD, Hedstrom L. Expanding benzoxazole based inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitor structure-activity as potential anti-tuberculosis agents. Journal of Medicinal Chemistry. PMID 29746130 DOI: 10.1021/acs.jmedchem.7b01839  0.52
2016 Wei Y, Kuzmic P, Yu R, Modi G, Hedstrom L. Inhibition of IMPDH from Bacillus anthracis: Mechanism revealed by pre-steady state kinetics. Biochemistry. PMID 27541177 DOI: 10.1021/acs.biochem.6b00265  1
2016 Coffey RT, Shi Y, Long MJ, Marr MT, Hedstrom L. Ubiquilin Mediated Small Molecule Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling. The Journal of Biological Chemistry. PMID 26740621 DOI: 10.1074/jbc.M115.691584  1
2015 Lawson AP, Long MJ, Coffey RT, Qian Y, Weerapana E, El Oualid F, Hedstrom L. Naturally occurring isothiocyanates exert anticancer effects by inhibiting deubiquitinating enzymes. Cancer Research. PMID 26542215 DOI: 10.1158/0008-5472.CAN-15-1544  1
2015 Makowska-Grzyska M, Kim Y, Gorla SK, Wei Y, Mandapati K, Zhang M, Maltseva N, Modi G, Boshoff HI, Gu M, Aldrich C, Cuny GD, Hedstrom L, Joachimiak A. Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds. Plos One. 10: e0138976. PMID 26440283 DOI: 10.1371/journal.pone.0138976  1
2015 Hedstrom L. Cryptosporidium: a first step toward tractability. Trends in Parasitology. 31: 401-2. PMID 26304816 DOI: 10.1016/j.pt.2015.08.003  1
2015 Kim Y, Makowska-Grzyska M, Gorla SK, Gollapalli DR, Cuny GD, Joachimiak A, Hedstrom L. Structure of Cryptosporidium IMP dehydrogenase bound to an inhibitor with in vivo antiparasitic activity. Acta Crystallographica. Section F, Structural Biology Communications. 71: 531-8. PMID 25945705 DOI: 10.1107/S2053230X15000187  1
2015 Makowska-Grzyska M, Kim Y, Maltseva N, Osipiuk J, Gu M, Zhang M, Mandapati K, Gollapalli DR, Gorla SK, Hedstrom L, Joachimiak A. A novel cofactor-binding mode in bacterial IMP dehydrogenases explains inhibitor selectivity. The Journal of Biological Chemistry. 290: 5893-911. PMID 25572472 DOI: 10.1074/jbc.M114.619767  1
2015 Checkley W, White AC, Jaganath D, Arrowood MJ, Chalmers RM, Chen XM, Fayer R, Griffiths JK, Guerrant RL, Hedstrom L, Huston CD, Kotloff KL, Kang G, Mead JR, Miller M, et al. A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium. The Lancet. Infectious Diseases. 15: 85-94. PMID 25278220 DOI: 10.1016/S1473-3099(14)70772-8  1
2014 Sun Z, Khan J, Makowska-Grzyska M, Zhang M, Cho JH, Suebsuwong C, Vo P, Gollapalli DR, Kim Y, Joachimiak A, Hedstrom L, Cuny GD. Synthesis, in vitro evaluation and cocrystal structure of 4-oxo-[1]benzopyrano[4,3-c]pyrazole Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase (CpIMPDH) inhibitors. Journal of Medicinal Chemistry. 57: 10544-50. PMID 25474504 DOI: 10.1021/jm501527z  1
2014 Kuang Y, Long MJ, Zhou J, Shi J, Gao Y, Xu C, Hedstrom L, Xu B. Prion-like nanofibrils of small molecules (PriSM) selectively inhibit cancer cells by impeding cytoskeleton dynamics. The Journal of Biological Chemistry. 289: 29208-18. PMID 25157102 DOI: 10.1074/jbc.M114.600288  1
2014 Mandapati K, Gorla SK, House AL, McKenney ES, Zhang M, Rao SN, Gollapalli DR, Mann BJ, Goldberg JB, Cuny GD, Glomski IJ, Hedstrom L. Repurposing cryptosporidium inosine 5'-monophosphate dehydrogenase inhibitors as potential antibacterial agents. Acs Medicinal Chemistry Letters. 5: 846-50. PMID 25147601 DOI: 10.1021/ml500203p  1
2014 Wang J, Han X, Wong CC, Cheng H, Aslanian A, Xu T, Leavis P, Roder H, Hedstrom L, Yates JR, Kashina A. Arginyltransferase ATE1 catalyzes midchain arginylation of proteins at side chain carboxylates in vivo. Chemistry & Biology. 21: 331-7. PMID 24529990 DOI: 10.1016/j.chembiol.2013.12.017  1
2014 Gorla SK, McNair NN, Yang G, Gao S, Hu M, Jala VR, Haribabu B, Striepen B, Cuny GD, Mead JR, Hedstrom L. Validation of IMP dehydrogenase inhibitors in a mouse model of cryptosporidiosis. Antimicrobial Agents and Chemotherapy. 58: 1603-14. PMID 24366728 DOI: 10.1128/AAC.02075-13  1
2013 Gorla SK, Kavitha M, Zhang M, Chin JE, Liu X, Striepen B, Makowska-Grzyska M, Kim Y, Joachimiak A, Hedstrom L, Cuny GD. Optimization of benzoxazole-based inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase. Journal of Medicinal Chemistry. 56: 4028-43. PMID 23668331 DOI: 10.1021/jm400241j  1
2013 Johnson CR, Gorla SK, Kavitha M, Zhang M, Liu X, Striepen B, Mead JR, Cuny GD, Hedstrom L. Phthalazinone inhibitors of inosine-5'-monophosphate dehydrogenase from Cryptosporidium parvum. Bioorganic & Medicinal Chemistry Letters. 23: 1004-7. PMID 23324406 DOI: 10.1016/j.bmcl.2012.12.037  1
2012 Gorla SK, Kavitha M, Zhang M, Liu X, Sharling L, Gollapalli DR, Striepen B, Hedstrom L, Cuny GD. Selective and potent urea inhibitors of cryptosporidium parvum inosine 5'-monophosphate dehydrogenase. Journal of Medicinal Chemistry. 55: 7759-71. PMID 22950983 DOI: 10.1021/jm3007917  1
2012 Long MJ, Hedstrom L. Mushroom tyrosinase oxidizes tyrosine-rich sequences to allow selective protein functionalization. Chembiochem : a European Journal of Chemical Biology. 13: 1818-25. PMID 22807021 DOI: 10.1002/cbic.201100792  1
2012 Gao Y, Long MJ, Shi J, Hedstrom L, Xu B. Using supramolecular hydrogels to discover the interactions between proteins and molecular nanofibers of small molecules. Chemical Communications (Cambridge, England). 48: 8404-6. PMID 22801479 DOI: 10.1039/c2cc33631f  1
2012 Makowska-Grzyska M, Kim Y, Wu R, Wilton R, Gollapalli DR, Wang XK, Zhang R, Jedrzejczak R, Mack JC, Maltseva N, Mulligan R, Binkowski TA, Gornicki P, Kuhn ML, Anderson WF, ... Hedstrom L, et al. Bacillus anthracis inosine 5'-monophosphate dehydrogenase in action: the first bacterial series of structures of phosphate ion-, substrate-, and product-bound complexes. Biochemistry. 51: 6148-63. PMID 22788966 DOI: 10.1021/bi300511w  1
2012 Long MJ, Gollapalli DR, Hedstrom L. Inhibitor mediated protein degradation. Chemistry & Biology. 19: 629-37. PMID 22633414 DOI: 10.1016/j.chembiol.2012.04.008  1
2012 Hedstrom L. The dynamic determinants of reaction specificity in the IMPDH/GMPR family of (β/α)(8) barrel enzymes. Critical Reviews in Biochemistry and Molecular Biology. 47: 250-63. PMID 22332716 DOI: 10.3109/10409238.2012.656843  1
2012 Kirubakaran S, Gorla SK, Sharling L, Zhang M, Liu X, Ray SS, Macpherson IS, Striepen B, Hedstrom L, Cuny GD. Structure-activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH. Bioorganic & Medicinal Chemistry Letters. 22: 1985-8. PMID 22310229 DOI: 10.1016/j.bmcl.2012.01.029  1
2012 McGrew DA, Hedstrom L. Towards a pathological mechanism for IMPDH1-linked retinitis pigmentosa. Advances in Experimental Medicine and Biology. 723: 539-45. PMID 22183375 DOI: 10.1007/978-1-4614-0631-0_68  1
2012 Hansen BG, Sun XE, Genee HJ, Kaas CS, Nielsen JB, Mortensen UH, Frisvad JC, Hedstrom L. Adaptive evolution of drug targets in producer and non-producer organisms. The Biochemical Journal. 441: 219-26. PMID 21916847 DOI: 10.1042/BJ20111278  1
2012 Pan Y, Long MJC, Lin HC, Hedstrom L, Xu B. Magnetic nanoparticles for direct protein sorting inside live cells Chemical Science. 3: 3495-3499. DOI: 10.1039/c2sc20519j  1
2011 MacPherson IS, Temme JS, Habeshian S, Felczak K, Pankiewicz K, Hedstrom L, Krauss IJ. Multivalent glycocluster design through directed evolution Angewandte Chemie - International Edition. 50: 11238-11242. PMID 22191092 DOI: 10.1002/anie.201105555  1
2011 Patton GC, Stenmark P, Gollapalli DR, Sevastik R, Kursula P, Flodin S, Schuler H, Swales CT, Eklund H, Himo F, Nordlund P, Hedstrom L. Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)8 barrel enzymes. Nature Chemical Biology. 7: 950-8. PMID 22037469 DOI: 10.1038/nchembio.693  1
2011 Sun XE, Hansen BG, Hedstrom L. Kinetically controlled drug resistance: how Penicillium brevicompactum survives mycophenolic acid. The Journal of Biological Chemistry. 286: 40595-600. PMID 21979957 DOI: 10.1074/jbc.M111.305235  1
2011 Riera TV, Zheng L, Josephine HR, Min D, Yang W, Hedstrom L. Allosteric activation via kinetic control: potassium accelerates a conformational change in IMP dehydrogenase. Biochemistry. 50: 8508-18. PMID 21870820 DOI: 10.1021/bi200785s  1
2011 Long MJ, Pan Y, Lin HC, Hedstrom L, Xu B. Cell compatible trimethoprim-decorated iron oxide nanoparticles bind dihydrofolate reductase for magnetically modulating focal adhesion of mammalian cells. Journal of the American Chemical Society. 133: 10006-9. PMID 21657789 DOI: 10.1021/ja202767g  1
2011 Hedstrom L, Liechti G, Goldberg JB, Gollapalli DR. The antibiotic potential of prokaryotic IMP dehydrogenase inhibitors Current Medicinal Chemistry. 18: 1909-1918. PMID 21517780 DOI: 10.2174/092986711795590129  1
2011 Hoefler BC, Gollapalli DR, Hedstrom L. Specific biotinylation of IMP dehydrogenase. Bioorganic & Medicinal Chemistry Letters. 21: 1363-5. PMID 21295473 DOI: 10.1016/j.bmcl.2011.01.042  1
2011 Pan Y, Long MJC, Li X, Shi J, Hedstrom L, Xu B. Glutathione (GSH)-decorated magnetic nanoparticles for binding glutathione-S-transferase (GST) fusion protein and manipulating live cells Chemical Science. 2: 945-948. DOI: 10.1039/c1sc00030f  1
2011 Gorla SK, Johnson C, Khan J, Sun X, Sharling L, Striepen B, Hedstrom L. Targeting prokaryotic enzymes in the eukaryotic pathogen cryptosporidium Apicomplexan Parasites: Molecular Approaches Toward Targeted Drug Development. 271-285. DOI: 10.1002/9783527633883.ch14  1
2010 Josephine HR, Ravichandran KR, Hedstrom L. The Cys319 loop modulates the transition between dehydrogenase and hydrolase conformations in inosine 5'-monophosphate dehydrogenase. Biochemistry. 49: 10674-81. PMID 21062060 DOI: 10.1021/bi101590c  1
2010 Gollapalli DR, Macpherson IS, Liechti G, Gorla SK, Goldberg JB, Hedstrom L. Structural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases. Chemistry & Biology. 17: 1084-91. PMID 21035731 DOI: 10.1016/j.chembiol.2010.07.014  1
2010 Mansfield BE, Oltean HN, Oliver BG, Hoot SJ, Leyde SE, Hedstrom L, White TC. Azole drugs are imported by facilitated diffusion in Candida albicans and other pathogenic fungi. Plos Pathogens. 6: e1001126. PMID 20941354 DOI: 10.1371/journal.ppat.1001126  1
2010 Sharling L, Liu X, Gollapalli DR, Maurya SK, Hedstrom L, Striepen B. A screening pipeline for antiparasitic agents targeting cryptosporidium inosine monophosphate dehydrogenase. Plos Neglected Tropical Diseases. 4: e794. PMID 20706578 DOI: 10.1371/journal.pntd.0000794  1
2010 Spellicy CJ, Xu D, Cobb G, Hedstrom L, Bowne SJ, Sullivan LS, Daiger SP. Investigating the mechanism of disease in the RP10 form of retinitis pigmentosa. Advances in Experimental Medicine and Biology. 664: 541-8. PMID 20238057 DOI: 10.1007/978-1-4419-1399-9_62  1
2010 Sun XE, Sharling L, Muthalagi M, Mudeppa DG, Pankiewicz KW, Felczak K, Rathod PK, Mead J, Striepen B, Hedstrom L. Prodrug activation by Cryptosporidium thymidine kinase. The Journal of Biological Chemistry. 285: 15916-22. PMID 20231284 DOI: 10.1074/jbc.M110.101543  1
2010 Macpherson IS, Kirubakaran S, Gorla SK, Riera TV, D'Aquino JA, Zhang M, Cuny GD, Hedstrom L. The structural basis of Cryptosporidium -specific IMP dehydrogenase inhibitor selectivity. Journal of the American Chemical Society. 132: 1230-1. PMID 20052976 DOI: 10.1021/ja909947a  1
2009 Maurya SK, Gollapalli DR, Kirubakaran S, Zhang M, Johnson CR, Benjamin NN, Hedstrom L, Cuny GD. Triazole inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase. Journal of Medicinal Chemistry. 52: 4623-30. PMID 19624136 DOI: 10.1021/jm900410u  1
2009 Sazonova IY, McNamee RA, Houng AK, King SM, Hedstrom L, Reed GL. Reprogrammed streptokinases develop fibrin-targeting and dissolve blood clots with more potency than tissue plasminogen activator. Journal of Thrombosis and Haemostasis : Jth. 7: 1321-8. PMID 19566545 DOI: 10.1111/j.1538-7836.2009.03491.x  1
2009 Hedstrom L. IMP dehydrogenase: structure, mechanism, and inhibition. Chemical Reviews. 109: 2903-28. PMID 19480389 DOI: 10.1021/cr900021w  1
2008 Mortimer SE, Xu D, McGrew D, Hamaguchi N, Lim HC, Bowne SJ, Daiger SP, Hedstrom L. IMP dehydrogenase type 1 associates with polyribosomes translating rhodopsin mRNA. The Journal of Biological Chemistry. 283: 36354-60. PMID 18974094 DOI: 10.1074/jbc.M806143200  1
2008 Min D, Josephine HR, Li H, Lakner C, MacPherson IS, Naylor GJ, Swofford D, Hedstrom L, Yang W. An enzymatic atavist revealed in dual pathways for water activation. Plos Biology. 6: e206. PMID 18752347 DOI: 10.1371/journal.pbio.0060206  1
2008 Riera TV, Wang W, Josephine HR, Hedstrom L. A kinetic alignment of orthologous inosine-5'-monophosphate dehydrogenases. Biochemistry. 47: 8689-96. PMID 18642884 DOI: 10.1021/bi800674a  1
2008 Hedstrom L. IMP dehydrogenase-linked retinitis pigmentosa. Nucleosides, Nucleotides & Nucleic Acids. 27: 839-49. PMID 18600550 DOI: 10.1080/15257770802146486  1
2008 Xu D, Cobb G, Spellicy CJ, Bowne SJ, Daiger SP, Hedstrom L. Retinal isoforms of inosine 5'-monophosphate dehydrogenase type 1 are poor nucleic acid binding proteins. Archives of Biochemistry and Biophysics. 472: 100-4. PMID 18295591 DOI: 10.1016/j.abb.2008.02.012  1
2008 Umejiego NN, Gollapalli D, Sharling L, Volftsun A, Lu J, Benjamin NN, Stroupe AH, Riera TV, Striepen B, Hedstrom L. Targeting a prokaryotic protein in a eukaryotic pathogen: identification of lead compounds against cryptosporidiosis. Chemistry & Biology. 15: 70-7. PMID 18215774 DOI: 10.1016/j.chembiol.2007.12.010  1
2008 Umejiego NN, Gollapalli D, Sharling L, Volftsun A, Lu J, Benjamin NN, Stroupe AH, Riera TV, Striepen B, Hedstrom L. Targeting a Prokaryotic Protein in a Eukaryotic Pathogen: Identification of Lead Compounds against Cryptosporidiosis (DOI:10.1016/j.chembiol.2007.12.010) Chemistry and Biology. 15: 200. DOI: 10.1016/j.chembiol.2008.02.007  1
2007 Liu L, Mushero N, Hedstrom L, Gershenson A. Short-lived protease serpin complexes: partial disruption of the rat trypsin active site. Protein Science : a Publication of the Protein Society. 16: 2403-11. PMID 17962402 DOI: 10.1110/ps.073111207  1
2007 Chen L, Gao G, Felczak K, Bonnac L, Patterson SE, Wilson D, Bennett EM, Jayaram HN, Hedstrom L, Pankiewicz KW. Probing binding requirements of type I and type II isoforms of inosine monophosphate dehydrogenase with adenine-modified nicotinamide adenine dinucleotide analogues. Journal of Medicinal Chemistry. 50: 5743-51. PMID 17958343 DOI: 10.1021/jm070568j  1
2007 Oram SW, Ai J, Pagani GM, Hitchens MR, Stern JA, Eggener S, Pins M, Xiao W, Cai X, Haleem R, Jiang F, Pochapsky TC, Hedstrom L, Wang Z. Expression and function of the human androgen-responsive gene ADI1 in prostate cancer. Neoplasia (New York, N.Y.). 9: 643-51. PMID 17786183 DOI: 10.1593/neo.07415  1
2007 Gladysheva IP, Sazonova IY, Houng A, Hedstrom L, Reed GL. Regulation of nonproteolytic active site formation in plasminogen. Biochemistry. 46: 8879-87. PMID 17616171 DOI: 10.1021/bi602591g  1
2006 Liu L, Mushero N, Hedstrom L, Gershenson A. Conformational distributions of protease-serpin complexes: a partially translocated complex. Biochemistry. 45: 10865-72. PMID 16953572 DOI: 10.1021/bi0609568  1
2006 Hedstrom L, Gan L. IMP dehydrogenase: structural schizophrenia and an unusual base. Current Opinion in Chemical Biology. 10: 520-5. PMID 16919497 DOI: 10.1016/j.cbpa.2006.08.005  1
2006 Rejman D, Olesiak M, Chen L, Patterson SE, Wilson D, Jayaram HN, Hedstrom L, Pankiewicz KW. Novel methylenephosphophosphonate analogues of mycophenolic adenine dinucleotide. Inhibition of inosine monophosphate dehydrogenase. Journal of Medicinal Chemistry. 49: 5018-22. PMID 16884314 DOI: 10.1021/jm060479r  1
2006 Bowne SJ, Sullivan LS, Mortimer SE, Hedstrom L, Zhu J, Spellicy CJ, Gire AI, Hughbanks-Wheaton D, Birch DG, Lewis RA, Heckenlively JR, Daiger SP. Spectrum and frequency of mutations in IMPDH1 associated with autosomal dominant retinitis pigmentosa and leber congenital amaurosis. Investigative Ophthalmology & Visual Science. 47: 34-42. PMID 16384941 DOI: 10.1167/iovs.05-0868  1
2005 Guillén Schlippe YV, Hedstrom L. Guanidine derivatives rescue the Arg418Ala mutation of Tritrichomonas foetus IMP dehydrogenase. Biochemistry. 44: 16695-700. PMID 16342959 DOI: 10.1021/bi051603w  1
2005 Guillén Schlippe YV, Hedstrom L. Is Arg418 the catalytic base required for the hydrolysis step of the IMP dehydrogenase reaction? Biochemistry. 44: 11700-7. PMID 16128570 DOI: 10.1021/bi048342v  1
2005 Mortimer SE, Hedstrom L. Autosomal dominant retinitis pigmentosa mutations in inosine 5'-monophosphate dehydrogenase type I disrupt nucleic acid binding. The Biochemical Journal. 390: 41-7. PMID 15882147 DOI: 10.1042/BJ20042051  1
2005 Köhler GA, Gong X, Bentink S, Theiss S, Pagani GM, Agabian N, Hedstrom L. The functional basis of mycophenolic acid resistance in Candida albicans IMP dehydrogenase. The Journal of Biological Chemistry. 280: 11295-302. PMID 15665003 DOI: 10.1074/jbc.M409847200  1
2005 Guillén Schlippe YV, Hedstrom L. A twisted base? The role of arginine in enzyme-catalyzed proton abstractions. Archives of Biochemistry and Biophysics. 433: 266-78. PMID 15581582 DOI: 10.1016/j.abb.2004.09.018  1
2004 Umejiego NN, Li C, Riera T, Hedstrom L, Striepen B. Cryptosporidium parvum IMP dehydrogenase: identification of functional, structural, and dynamic properties that can be exploited for drug design. The Journal of Biological Chemistry. 279: 40320-7. PMID 15269207 DOI: 10.1074/jbc.M407121200  1
2004 Zhang Y, Heinsen MH, Kostic M, Pagani GM, Riera TV, Perovic I, Hedstrom L, Snider BB, Pochapsky TC. Analogs of 1-phosphonooxy-2,2-dihydroxy-3-oxo-5-(methylthio)pentane, an acyclic intermediate in the methionine salvage pathway: a new preparation and characterization of activity with E1 enolase/phosphatase from Klebsiella oxytoca. Bioorganic & Medicinal Chemistry. 12: 3847-55. PMID 15210152 DOI: 10.1016/j.bmc.2004.05.002  1
2004 Guillén Schlippe YV, Riera TV, Seyedsayamdost MR, Hedstrom L. Substitution of the conserved Arg-Tyr dyad selectively disrupts the hydrolysis phase of the IMP dehydrogenase reaction. Biochemistry. 43: 4511-21. PMID 15078097 DOI: 10.1021/bi035823q  1
2004 Striepen B, Pruijssers AJ, Huang J, Li C, Gubbels MJ, Umejiego NN, Hedstrom L, Kissinger JC. Gene transfer in the evolution of parasite nucleotide biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 101: 3154-9. PMID 14973196 DOI: 10.1073/pnas.0304686101  1
2004 McLean JE, Hamaguchi N, Belenky P, Mortimer SE, Stanton M, Hedstrom L. Inosine 5'-monophosphate dehydrogenase binds nucleic acids in vitro and in vivo. The Biochemical Journal. 379: 243-51. PMID 14766016 DOI: 10.1042/BJ20031585  1
2003 Hedstrom L, Gan L, Schlippe YG, Riera T, Seyedsayamdost M. IMP dehydrogenase: the dynamics of drug selectivity. Nucleic Acids Research. Supplement (2001). 97-8. PMID 14510398  1
2003 Sivaraman S, Zwahlen J, Bell AF, Hedstrom L, Tonge PJ. Structure-activity studies of the inhibition of FabI, the enoyl reductase from Escherichia coli, by triclosan: kinetic analysis of mutant FabIs. Biochemistry. 42: 4406-13. PMID 12693936 DOI: 10.1021/bi0300229  1
2003 Gan L, Seyedsayamdost MR, Shuto S, Matsuda A, Petsko GA, Hedstrom L. The immunosuppressive agent mizoribine monophosphate forms a transition state analogue complex with inosine monophosphate dehydrogenase. Biochemistry. 42: 857-63. PMID 12549902 DOI: 10.1021/bi0271401  1
2002 Hedstrom L. An overview of serine proteases. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. Unit 21.10. PMID 18429229 DOI: 10.1002/0471140864.ps2110s26  1
2002 Hedstrom L. Serine protease mechanism and specificity. Chemical Reviews. 102: 4501-24. PMID 12475199 DOI: 10.1021/cr000033x  1
2002 Gan L, Petsko GA, Hedstrom L. Crystal structure of a ternary complex of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase: NAD+ orients the active site loop for catalysis. Biochemistry. 41: 13309-17. PMID 12403633 DOI: 10.1021/bi0203785  1
2002 Mellet P, Mély Y, Hedstrom L, Cahoon M, Belorgey D, Srividya N, Rubin H, Bieth JG. Comparative trajectories of active and S195A inactive trypsin upon binding to serpins. The Journal of Biological Chemistry. 277: 38901-14. PMID 12077135 DOI: 10.1074/jbc.M204090200  1
2002 Hedstrom L. Introduction: Proteases Chemical Reviews. 102: 4429. DOI: 10.1021/cr0101712  1
2001 Huang X, Knoell CT, Frey G, Hazegh-Azam M, Tashjian AH, Hedstrom L, Abeles RH, Timasheff SN. Modulation of recombinant human prostate-specific antigen: activation by Hofmeister salts and inhibition by azapeptides. Appendix: thermodynamic interpretation of the activation by concentrated salts. Biochemistry. 40: 11734-41. PMID 11570874 DOI: 10.1021/bi010364j  1
2001 Pasternak A, White A, Jeffery CJ, Medina N, Cahoon M, Ringe D, Hedstrom L. The energetic cost of induced fit catalysis: Crystal structures of trypsinogen mutants with enhanced activity and inhibitor affinity. Protein Science : a Publication of the Protein Society. 10: 1331-42. PMID 11420435 DOI: 10.1110/ps.44101  1
2001 McLean JE, Neidhardt EA, Grossman TH, Hedstrom L. Multiple inhibitor analysis of the brequinar and leflunomide binding sites on human dihydroorotate dehydrogenase. Biochemistry. 40: 2194-200. PMID 11329288 DOI: 10.1021/bi001810q  1
2001 Sazonova IY, Houng AK, Chowdhry SA, Robinson BR, Hedstrom L, Reed GL. The mechanism of a bacterial plasminogen activator intermediate between streptokinase and staphylokinase. The Journal of Biological Chemistry. 276: 12609-13. PMID 11278483 DOI: 10.1074/jbc.M009265200  1
2000 Hedstrom L, Frey PA. Robert H. Abeles (1926-2000). Nature. 407: 854. PMID 11057653 DOI: 10.1038/35038202  1
2000 Kerr KM, Digits JA, Kuperwasser N, Hedstrom L. Asp338 controls hydride transfer in Escherichia coli IMP dehydrogenase. Biochemistry. 39: 9804-10. PMID 10933797 DOI: 10.1021/bi0005409  1
2000 Wang S, Reed GL, Hedstrom L. Zymogen activation in the streptokinase-plasminogen complex. Ile1 is required for the formation of a functional active site. European Journal of Biochemistry / Febs. 267: 3994-4001. PMID 10866798 DOI: 10.1046/j.1432-1327.2000.01434.x  1
2000 Dai Y, Hedstrom L, Abeles RH. Inactivation of cysteine proteases by (acyloxy)methyl ketones using S'-P' interactions. Biochemistry. 39: 6498-502. PMID 10828965 DOI: 10.1021/bi0002378  1
2000 McMillan FM, Cahoon M, White A, Hedstrom L, Petsko GA, Ringe D. Crystal structure at 2.4 A resolution of Borrelia burgdorferi inosine 5'-monophosphate dehydrogenase: evidence of a substrate-induced hinged-lid motion by loop 6. Biochemistry. 39: 4533-42. PMID 10758003 DOI: 10.1021/bi992645l  1
2000 Kerr KM, Cahoon M, Bosco DA, Hedstrom L. Monovalent cation activation in Escherichia coli inosine 5'-monophosphate dehydrogenase. Archives of Biochemistry and Biophysics. 375: 131-7. PMID 10683258 DOI: 10.1006/abbi.1999.1644  1
2000 Digits JA, Hedstrom L. Drug selectivity is determined by coupling across the NAD+ site of IMP dehydrogenase. Biochemistry. 39: 1771-7. PMID 10677226 DOI: 10.1021/bi992288e  1
1999 Neidhardt EA, Punreddy SR, McLean JE, Hedstrom L, Grossman TH. Expression and characterization of E. coli-produced soluble, functional human dihydroorotate dehydrogenase: a potential target for immunosuppression. Journal of Molecular Microbiology and Biotechnology. 1: 183-8. PMID 10941801  1
1999 Digits JA, Hedstrom L. Species-specific inhibition of inosine 5'-monophosphate dehydrogenase by mycophenolic acid. Biochemistry. 38: 15388-97. PMID 10563825 DOI: 10.1021/bi991558q  1
1999 Reed GL, Houng AK, Liu L, Parhami-Seren B, Matsueda LH, Wang S, Hedstrom L. A catalytic switch and the conversion of streptokinase to a fibrin-targeted plasminogen activator. Proceedings of the National Academy of Sciences of the United States of America. 96: 8879-83. PMID 10430864 DOI: 10.1073/pnas.96.16.8879  1
1999 Hedstrom L. IMP dehydrogenase: Mechanism of action and inhibition Current Medicinal Chemistry. 6: 545-560. PMID 10390600  1
1999 Wang S, Reed GL, Hedstrom L. Deletion of Ile1 changes the mechanism of streptokinase: evidence for the molecular sexuality hypothesis. Biochemistry. 38: 5232-40. PMID 10213631 DOI: 10.1021/bi981915h  1
1999 Pasternak A, Ringe D, Hedstrom L. Comparison of anionic and cationic trypsinogens: the anionic activation domain is more flexible in solution and differs in its mode of BPTI binding in the crystal structure. Protein Science : a Publication of the Protein Society. 8: 253-8. PMID 10210204 DOI: 10.1110/ps.8.1.253  1
1999 Digits JA, Hedstrom L. Kinetic mechanism of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase. Biochemistry. 38: 2295-306. PMID 10029522 DOI: 10.1021/bi982305k  1
1998 Pasternak A, Liu X, Lin TY, Hedstrom L. Activating a zymogen without proteolytic processing: Mutation of Lys15 and Asn194 activates trypsinogen Biochemistry. 37: 16201-16210. PMID 9819212 DOI: 10.1021/bi980951d  1
1998 Hung SH, Hedstrom L. Converting trypsin to elastase: Substitution of the S1 site and adjacent loops reconstitutes esterase specificity but not amidase activity Protein Engineering. 11: 669-673. PMID 9749919  1
1998 Wang W, Hedstrom L. A potent 'fat base' nucleotide inhibitor of IMP dehydrogenase Biochemistry. 37: 11949-11952. PMID 9718319 DOI: 10.1021/bi981132w  1
1998 Kurth T, Grahn S, Thormann M, Ullmann D, Hofmann HJ, Jakubke HD, Hedstrom L. Engineering the S1' subsite of trypsin: Design of a protease which cleaves between dibasic residues Biochemistry. 37: 11434-11440. PMID 9708978 DOI: 10.1021/bi980842z  1
1997 Kerr KM, Hedstrom L. The roles of conserved carboxylate residues in IMP dehydrogenase and identification of a transition state analog. Biochemistry. 36: 13365-73. PMID 9341229 DOI: 10.1021/bi9714161  1
1997 Zhou X, Cahoon M, Rosa P, Hedstrom L. Expression, purification, and characterization of inosine 5'- monophosphate dehydrogenase from Borrelia burgdorferi Journal of Biological Chemistry. 272: 21977-21981. PMID 9268334 DOI: 10.1074/jbc.272.35.21977  1
1997 Kurth T, Ullmann D, Jakubke HD, Hedstrom L. Converting trypsin to chymotrypsin: Structural determinants of S1' specificity Biochemistry. 36: 10098-10104. PMID 9254605 DOI: 10.1021/bi970937l  1
1997 Wang W, Hedstrom L. Kinetic mechanism of human inosine 5'-monophosphate dehydrogenase type II: Random addition of substrates and ordered release of products Biochemistry. 36: 8479-8483. PMID 9214292 DOI: 10.1021/bi970226n  1
1997 Wang ECW, Hung SH, Cahoon M, Hedstrom L. The role of the Cys191-Cys220 disulfide bond in trypsin: New targets for engineering substrate specificity Protein Engineering. 10: 405-411. PMID 9194165  1
1997 Farazi T, Leichman J, Harris T, Cahoon M, Hedstrom L. Isolation and characterization of mycophenolic acid-resistant mutants of inosine-5'-monophosphate dehydrogenase Journal of Biological Chemistry. 272: 961-965. PMID 8995388 DOI: 10.1074/jbc.272.2.961  1
1996 Venekei I, Hedstrom L, Rutter WJ. A rapid and effective procedure for screening protease mutants. Protein Engineering. 9: 85-93. PMID 9053907  1
1996 Hedstrom L. Trypsin: A case study in the structural determinants of enzyme specificity Biological Chemistry. 377: 465-470. PMID 8922280  1
1996 Hedstrom L, Lin TY, Fast W. Hydrophobic interactions control zymogen activation in the trypsin family of serine proteases Biochemistry. 35: 4515-4523. PMID 8605201 DOI: 10.1021/bi951928k  1
1996 Wang W, Papov VV, Minakawa N, Matsuda A, Biemann K, Hedstrom L. Inactivation of inosine 5'-monophosphate dehydrogenase by the antiviral agent 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide 5'-monophosphate. Biochemistry. 35: 95-101. PMID 8555204 DOI: 10.1021/bi951499q  1
1996 Kerr KM, Hedstrom L. EDC inactivation implicates carboxylate residues in the mechanism of E. Coli IMPDH Faseb Journal. 10: A971.  1
1995 Perona JJ, Hedstrom L, Rutter WJ, Fletterick RJ. Structural origins of substrate discrimination in trypsin and chymotrypsin. Biochemistry. 34: 1489-99. PMID 7849008  1
1994 Perona JJ, Hedstrom L, Wagner RL, Rutter WJ, Craik CS, Fletterick RJ. Exogenous acetate reconstitutes the enzymatic activity of trypsin Asp189Ser. Biochemistry. 33: 3252-9. PMID 8136360  1
1994 Hedstrom L, Farr-Jones S, Kettner CA, Rutter WJ. Converting trypsin to chymotrypsin: ground-state binding does not determine substrate specificity. Biochemistry. 33: 8764-9. PMID 8038166 DOI: 10.1021/bi00195a018  1
1994 Hedstrom L, Perona JJ, Rutter WJ. Converting trypsin to chymotrypsin: residue 172 is a substrate specificity determinant. Biochemistry. 33: 8757-63. PMID 8038165 DOI: 10.1021/bi00195a017  1
1994 Hedstrom L. Engineering for redesign Current Opinion in Structural Biology. 4: 608-611. DOI: 10.1016/S0959-440X(94)90225-9  1
1993 Schellenberger V, Turck CW, Hedstrom L, Rutter WJ. Mapping the S' subsites of serine proteases using acyl transfer to mixtures of peptide nucleophiles. Biochemistry. 32: 4349-53. PMID 8476865  1
1992 Hedstrom L, Szilagyi L, Rutter WJ. Converting trypsin to chymotrypsin: the role of surface loops. Science (New York, N.Y.). 255: 1249-53. PMID 1546324  1
1992 Phillips MA, Hedstrom L, Rutter WJ. Guanidine derivatives restore activity to carboxypeptidase lacking arginine-127. Protein Science : a Publication of the Protein Society. 1: 517-21. PMID 1304353 DOI: 10.1002/pro.5560010406  1
1991 Hedstrom L, Graf L, Stewart CB, Rutter WJ, Phillips MA. Modulation of enzyme specificity by site-directed mutagenesis. Methods in Enzymology. 202: 671-87. PMID 1784193  1
1990 Hedstrom L, Wang CC. Mycophenolic acid and thiazole adenine dinucleotide inhibition of tritrichomonas foetus inosine 5′-monophosphate dehydrogenase: Implications on enzyme mechanism Biochemistry. 29: 849-854. PMID 1971185  1
1990 Hedstrom L, Cheung KS, Wang CC. A novel mechanism of mycophenolic acid resistance in the protozoan parasite tritrichomonas foetus Biochemical Pharmacology. 39: 151-160. PMID 1967525 DOI: 10.1016/0006-2952(90)90659-9  1
1989 Hedstrom L, Wang CC. Purine base transport in wild-type and mycophenolic acid-resistant Tritrichomonas foetus Molecular and Biochemical Parasitology. 35: 219-227. PMID 2747744 DOI: 10.1016/0166-6851(89)90208-9  1
1988 Hedstrom L, Abeles R. 3-Deoxy-D-manno-octulosonate-8-phosphate synthase catalyzes the C-O bond cleavage of phosphoenolpyruvate Biochemical and Biophysical Research Communications. 157: 816-820. PMID 2904815 DOI: 10.1016/S0006-291X(88)80322-X  1
1987 Verham R, Meek TD, Hedstrom L, Wang CC. Purification, characterization, and kinetic analysis of inosine 5′-monophosphate dehydrogenase of Tritrichomonas foetus Molecular and Biochemical Parasitology. 24: 1-12. PMID 2886911 DOI: 10.1016/0166-6851(87)90110-1  1
1984 Hedstrom L, Moorman AR, Dobbs J, Abeles RH. Suicide inactivation of chymotrypsin by benzoxazinones. Biochemistry. 23: 1753-9. PMID 6562904  1
1983 Anton DL, Hedstrom L, Fish SM, Abeles RH. Mechanism of enolpyruvyl shikimate-3-phosphate synthase exchange of phosphoenolpyruvate with solvent protons Biochemistry. 22: 5903-5908.  1
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