Andre J. Ouellette - Publications

Affiliations: 
Genetic, Molecular, and Cell Biology University of Southern California, Los Angeles, CA, United States 
Area:
Immunology, Biochemistry, Microbiology Biology, Cell Biology

96 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Basso V, Tran DQ, Schaal JB, Tran P, Eriguchi Y, Ngole D, Cabebe AE, Park AY, Beringer PM, Ouellette AJ, Selsted ME. Rhesus Theta Defensin 1 Promotes Long Term Survival in Systemic Candidiasis by Host Directed Mechanisms. Scientific Reports. 9: 16905. PMID 31729441 DOI: 10.1038/S41598-019-53402-Z  0.352
2018 Cobo ER, Holani R, Moreau F, Nakamura K, Ayabe T, Mastroianni JR, Eriguchi Y, Ouellette A, Chadee K. Correction for Cobo et al., "Entamoeba histolytica Alters Ileal Paneth Cell Functions in Intact and Muc2 Mucin Deficiency". Infection and Immunity. 86. PMID 30242014 DOI: 10.1128/Iai.00564-18  0.727
2018 Eriguchi Y, Nakamura K, Yokoi Y, Sugimoto R, Takahashi S, Hashimoto D, Teshima T, Ayabe T, Selsted ME, Ouellette AJ. Essential role of IFN-γ in T cell-associated intestinal inflammation. Jci Insight. 3. PMID 30232288 DOI: 10.1172/Jci.Insight.121886  0.403
2018 Cobo ER, Holani R, Moreau F, Nakamura K, Ayabe T, Mastroianni JR, Ouellette A, Chadee K. Alters ileal Paneth Cell Functions in Intact and Muc2 Mucin Deficiency. Infection and Immunity. PMID 29685982 DOI: 10.1128/Iai.00208-18  0.794
2018 Basso V, Garcia A, Tran DQ, Schaal JB, Tran P, Ngole D, Aqeel Y, Tongaonkar P, Ouellette AJ, Selsted ME. Fungicidal potency and mechanisms of θ-defensins against multi-drug resistantspecies. Antimicrobial Agents and Chemotherapy. PMID 29610196 DOI: 10.1128/Aac.00111-18  0.359
2018 Schaal JB, Maretzky T, Tran DQ, Tran PA, Tongaonkar P, Blobel CP, Ouellette AJ, Selsted ME. Macrocyclic θ-defensins suppress tumor necrosis factor-α (TNF-α) shedding by inhibition of TNF-α converting enzyme. The Journal of Biological Chemistry. PMID 29317500 DOI: 10.1074/Jbc.Ra117.000793  0.373
2017 Schaal JB, Tran DQ, Subramanian A, Patel R, Laragione T, Roberts KD, Trinh K, Tongaonkar P, Tran PA, Minond D, Fields GB, Beringer P, Ouellette AJ, Gulko PS, Selsted ME. Suppression and resolution of autoimmune arthritis by rhesus θ-defensin-1, an immunomodulatory macrocyclic peptide. Plos One. 12: e0187868. PMID 29145473 DOI: 10.1371/Journal.Pone.0187868  0.346
2016 Nevins AM, Subramanian A, Tapia JL, Delgado DP, Tyler RC, Jensen DR, Ouellette AJ, Volkman BF. A Requirement for Metamorphic Interconversion in the Antimicrobial Activity of the Chemokine XCL1. Biochemistry. PMID 27305837 DOI: 10.1021/Acs.Biochem.6B00353  0.384
2016 Diaz-Ochoa VE, Lam D, Lee CS, Klaus S, Behnsen J, Liu JZ, Chim N, Nuccio SP, Rathi SG, Mastroianni JR, Edwards RA, Jacobo CM, Cerasi M, Battistoni A, Ouellette AJ, et al. Salmonella Mitigates Oxidative Stress and Thrives in the Inflamed Gut by Evading Calprotectin-Mediated Manganese Sequestration. Cell Host & Microbe. 19: 814-825. PMID 27281571 DOI: 10.1016/J.Chom.2016.05.005  0.759
2016 Gounder AP, Myers ND, Treuting PM, Bromme BA, Wilson SS, Wiens ME, Lu W, Ouellette AJ, Spindler KR, Parks WC, Smith JG. Defensins Potentiate a Neutralizing Antibody Response to Enteric Viral Infection. Plos Pathogens. 12: e1005474. PMID 26933888 DOI: 10.1371/Journal.Ppat.1005474  0.391
2015 Tongaonkar P, Trinh KK, Schaal JB, Tran D, Gulko PS, Ouellette AJ, Selsted ME. Rhesus macaque θ-defensin RTD-1 inhibits proinflammatory cytokine secretion and gene expression by inhibiting the activation of NF-κB and MAPK pathways. Journal of Leukocyte Biology. PMID 26269197 DOI: 10.1189/Jlb.3A0315-102R  0.347
2015 Tai KP, Kamdar K, Yamaki J, Le VV, Tran D, Tran P, Selsted ME, Ouellette AJ, Wong-Beringer A. Microbicidal effects of α- and θ-defensins against antibiotic-resistant Staphylococcus aureus and Pseudomonas aeruginosa. Innate Immunity. 21: 17-29. PMID 24345876 DOI: 10.1177/1753425913514784  0.705
2015 Ouellette AJ. Defensins in Enteric Mucosal Immunity Mucosal Immunology: Fourth Edition. 1: 271-285. DOI: 10.1016/B978-0-12-415847-4.00016-1  0.372
2014 Wilmes M, Stockem M, Bierbaum G, Schlag M, Götz F, Tran DQ, Schaal JB, Ouellette AJ, Selsted ME, Sahl HG. Killing of staphylococci by θ-defensins involves membrane impairment and activation of autolytic enzymes. Antibiotics (Basel, Switzerland). 3: 617-631. PMID 25632351 DOI: 10.3390/Antibiotics3040617  0.385
2014 Mastroianni JR, Lu W, Selsted ME, Ouellette AJ. Differential Susceptibility of Bacteria to Mouse Paneth Cell α-Defensins under Anaerobic Conditions. Antibiotics (Basel, Switzerland). 3: 493-508. PMID 25383215 DOI: 10.3390/Antibiotics3040493  0.782
2014 Tai KP, Le VV, Selsted ME, Ouellette AJ. Hydrophobic determinants of α-defensin bactericidal activity. Infection and Immunity. 82: 2195-202. PMID 24614658 DOI: 10.1128/Iai.01414-13  0.732
2013 Patil AA, Ouellette AJ, Lu W, Zhang G. Rattusin, an intestinal α-defensin-related peptide in rats with a unique cysteine spacing pattern and salt-insensitive antibacterial activities. Antimicrobial Agents and Chemotherapy. 57: 1823-31. PMID 23380721 DOI: 10.1128/Aac.02237-12  0.46
2012 Schaal JB, Tran D, Tran P, Ösapay G, Trinh K, Roberts KD, Brasky KM, Tongaonkar P, Ouellette AJ, Selsted ME. Rhesus macaque theta defensins suppress inflammatory cytokines and enhance survival in mouse models of bacteremic sepsis. Plos One. 7: e51337. PMID 23236475 DOI: 10.1371/Journal.Pone.0051337  0.392
2012 Ouellette AJ, Selsted ME. Immunology. HD6 defensin nanonets. Science (New York, N.Y.). 337: 420-1. PMID 22837514 DOI: 10.1126/Science.1225906  0.379
2012 Burkhardt AM, Tai KP, Flores-Guiterrez JP, Vilches-Cisneros N, Kamdar K, Barbosa-Quintana O, Valle-Rios R, Hevezi PA, Zuñiga J, Selman M, Ouellette AJ, Zlotnik A. CXCL17 is a mucosal chemokine elevated in idiopathic pulmonary fibrosis that exhibits broad antimicrobial activity. Journal of Immunology (Baltimore, Md. : 1950). 188: 6399-406. PMID 22611239 DOI: 10.4049/Jimmunol.1102903  0.736
2012 Schmidt NW, Tai KP, Kamdar K, Mishra A, Lai GH, Zhao K, Ouellette AJ, Wong GC. Arginine in α-defensins: differential effects on bactericidal activity correspond to geometry of membrane curvature generation and peptide-lipid phase behavior. The Journal of Biological Chemistry. 287: 21866-72. PMID 22566697 DOI: 10.1074/Jbc.M112.358721  0.726
2012 Tongaonkar P, Golji AE, Tran P, Ouellette AJ, Selsted ME. High fidelity processing and activation of the human α-defensin HNP1 precursor by neutrophil elastase and proteinase 3. Plos One. 7: e32469. PMID 22448222 DOI: 10.1371/Journal.Pone.0032469  0.445
2012 Mastroianni JR, Costales JK, Zaksheske J, Selsted ME, Salzman NH, Ouellette AJ. Alternative luminal activation mechanisms for paneth cell α-defensins. The Journal of Biological Chemistry. 287: 11205-12. PMID 22334698 DOI: 10.1074/Jbc.M111.333559  0.77
2012 Andersson HS, Figueredo SM, Haugaard-Kedström LM, Bengtsson E, Daly NL, Qu X, Craik DJ, Ouellette AJ, Rosengren KJ. The α-defensin salt-bridge induces backbone stability to facilitate folding and confer proteolytic resistance. Amino Acids. 43: 1471-83. PMID 22286872 DOI: 10.1007/S00726-012-1220-3  0.388
2011 Garcia AE, Tai KP, Puttamadappa SS, Shekhtman A, Ouellette AJ, Camarero JA. Biosynthesis and antimicrobial evaluation of backbone-cyclized α-defensins. Biochemistry. 50: 10508-19. PMID 22040603 DOI: 10.1021/Bi201430F  0.761
2011 Ouellette AJ. Paneth cell α-defensins in enteric innate immunity Cellular and Molecular Life Sciences. 68: 2215-2229. PMID 21560070 DOI: 10.1007/S00018-011-0714-6  0.472
2011 Schmidt NW, Mishra A, Lai GH, Davis M, Sanders LK, Tran D, Garcia A, Tai KP, McCray PB, Ouellette AJ, Selsted ME, Wong GC. Criterion for amino acid composition of defensins and antimicrobial peptides based on geometry of membrane destabilization. Journal of the American Chemical Society. 133: 6720-7. PMID 21473577 DOI: 10.1021/Ja200079A  0.709
2011 Mishra A, Tai KP, Schmidt NW, Ouellette AJ, Wong GC. Small-angle X-ray scattering studies of peptide-lipid interactions using the mouse paneth cell α-defensin cryptdin-4. Methods in Enzymology. 492: 127-49. PMID 21333790 DOI: 10.1016/B978-0-12-381268-1.00016-1  0.729
2011 Zaragoza MM, Sankaran-Walters S, Canfield DR, Hung JK, Martinez E, Ouellette AJ, Dandekar S. Persistence of gut mucosal innate immune defenses by enteric α-defensin expression in the simian immunodeficiency virus model of AIDS. Journal of Immunology (Baltimore, Md. : 1950). 186: 1589-97. PMID 21178012 DOI: 10.4049/Jimmunol.1002021  0.349
2011 Tongaonkar P, Tran P, Roberts K, Schaal J, Osapay G, Tran D, Ouellette AJ, Selsted ME. Rhesus macaque θ-defensin isoforms: expression, antimicrobial activities, and demonstration of a prominent role in neutrophil granule microbicidal activities. Journal of Leukocyte Biology. 89: 283-90. PMID 21084627 DOI: 10.1189/Jlb.0910535  0.415
2011 Shanahan MT, Tanabe H, Ouellette AJ. Strain-specific polymorphisms in Paneth cell α-defensins of C57BL/6 mice and evidence of vestigial myeloid α-defensin pseudogenes. Infection and Immunity. 79: 459-73. PMID 21041494 DOI: 10.1128/Iai.00996-10  0.348
2010 Ouellette AJ. Paneth cells and innate mucosal immunity. Current Opinion in Gastroenterology. 26: 547-53. PMID 20693892 DOI: 10.1097/Mog.0B013E32833Dccde  0.347
2010 Figueredo S, Mastroianni JR, Tai KP, Ouellette AJ. Expression and purification of recombinant alpha-defensins and alpha-defensin precursors in Escherichia coli. Methods in Molecular Biology (Clifton, N.J.). 618: 47-60. PMID 20094857 DOI: 10.1007/978-1-60761-594-1_4  0.748
2010 Shanahan MT, Vidrich A, Shirafuji Y, Dubois CL, Henschen-Edman A, Hagen SJ, Cohn SM, Ouellette AJ. Elevated expression of Paneth cell CRS4C in ileitis-prone SAMP1/YitFc mice: regional distribution, subcellular localization, and mechanism of action. The Journal of Biological Chemistry. 285: 7493-504. PMID 20056603 DOI: 10.1074/Jbc.M109.083220  0.511
2010 Zhao F, Edwards R, Dizon D, Afrasiabi K, Mastroianni JR, Geyfman M, Ouellette AJ, Andersen B, Lipkin SM. Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice. Developmental Biology. 338: 270-9. PMID 20025862 DOI: 10.1016/J.Ydbio.2009.12.008  0.759
2010 Figueredo SM, Ouellette AJ. Inhibition of bactericidal activity is maintained in a mouse alpha-defensin precursor with proregion truncations. Peptides. 31: 9-15. PMID 19837119 DOI: 10.1016/J.Peptides.2009.10.004  0.42
2010 Ouellette AJ, Niklas V. Paneth cells in intestinal health and disease in the newborn Neoreviews. 11. DOI: 10.1542/neo.11-10-e551  0.385
2009 Llenado RA, Weeks CS, Cocco MJ, Ouellette AJ. Electropositive charge in alpha-defensin bactericidal activity: functional effects of Lys-for-Arg substitutions vary with the peptide primary structure. Infection and Immunity. 77: 5035-43. PMID 19737896 DOI: 10.1128/Iai.00695-09  0.388
2009 Mastroianni JR, Ouellette AJ. Alpha-defensins in enteric innate immunity: functional Paneth cell alpha-defensins in mouse colonic lumen. The Journal of Biological Chemistry. 284: 27848-56. PMID 19687006 DOI: 10.1074/Jbc.M109.050773  0.796
2009 Figueredo SM, Weeks CS, Young SK, Ouellette AJ. Anionic amino acids near the pro-alpha-defensin N terminus mediate inhibition of bactericidal activity in mouse pro-cryptdin-4. The Journal of Biological Chemistry. 284: 6826-31. PMID 19106102 DOI: 10.1074/Jbc.M807024200  0.408
2008 Hadjicharalambous C, Sheynis T, Jelinek R, Shanahan MT, Ouellette AJ, Gizeli E. Mechanisms of alpha-defensin bactericidal action: comparative membrane disruption by Cryptdin-4 and its disulfide-null analogue. Biochemistry. 47: 12626-34. PMID 18973303 DOI: 10.1021/Bi800335E  0.359
2008 Kamdar K, Maemoto A, Qu X, Young SK, Ouellette AJ. In vitro activation of the rhesus macaque myeloid alpha-defensin precursor proRMAD-4 by neutrophil serine proteinases. The Journal of Biological Chemistry. 283: 32361-8. PMID 18775986 DOI: 10.1074/Jbc.M805296200  0.452
2008 Tran D, Tran P, Roberts K, Osapay G, Schaal J, Ouellette A, Selsted ME. Microbicidal properties and cytocidal selectivity of rhesus macaque theta defensins. Antimicrobial Agents and Chemotherapy. 52: 944-53. PMID 18160518 DOI: 10.1128/Aac.01090-07  0.435
2008 Miszta A, Machán R, Benda A, Ouellette AJ, Hermens WT, Hof M. Combination of ellipsometry, laser scanning microscopy and Z-scan fluorescence correlation spectroscopy elucidating interaction of cryptdin-4 with supported phospholipid bilayers. Journal of Peptide Science : An Official Publication of the European Peptide Society. 14: 503-9. PMID 17994618 DOI: 10.1002/Psc.938  0.324
2007 Shi J, Aono S, Lu W, Ouellette AJ, Hu X, Ji Y, Wang L, Lenz S, van Ginkel FW, Liles M, Dykstra C, Morrison EE, Elson CO. A novel role for defensins in intestinal homeostasis: regulation of IL-1beta secretion. Journal of Immunology (Baltimore, Md. : 1950). 179: 1245-53. PMID 17617617 DOI: 10.4049/Jimmunol.179.2.1245  0.331
2006 Ouellette AJ. Paneth cell α-defensin synthesis and function Current Topics in Microbiology and Immunology. 306: 1-25. PMID 16909916  0.397
2006 Rosengren KJ, Daly NL, Fornander LM, Jönsson LM, Shirafuji Y, Qu X, Vogel HJ, Ouellette AJ, Craik DJ. Structural and functional characterization of the conserved salt bridge in mammalian paneth cell alpha-defensins: solution structures of mouse CRYPTDIN-4 and (E15D)-CRYPTDIN-4. The Journal of Biological Chemistry. 281: 28068-78. PMID 16857681 DOI: 10.1074/Jbc.M604992200  0.424
2006 Weeks CS, Tanabe H, Cummings JE, Crampton SP, Sheynis T, Jelinek R, Vanderlick TK, Cocco MJ, Ouellette AJ. Matrix metalloproteinase-7 activation of mouse paneth cell pro-alpha-defensins: SER43 down arrow ILE44 proteolysis enables membrane-disruptive activity. The Journal of Biological Chemistry. 281: 28932-42. PMID 16822871 DOI: 10.1074/Jbc.M602041200  0.472
2006 Ouellette AJ. Paneth Cell Α-Defensins Handbook of Biologically Active Peptides. 1029-1035. DOI: 10.1016/B978-012369442-3/50144-6  0.346
2005 Ouellette AJ. Paneth cell alpha-defensins: peptide mediators of innate immunity in the small intestine. Springer Seminars in Immunopathology. 27: 133-46. PMID 15931529 DOI: 10.1007/S00281-005-0202-X  0.484
2005 Selsted ME, Ouellette AJ. Mammalian defensins in the antimicrobial immune response. Nature Immunology. 6: 551-7. PMID 15908936 DOI: 10.1146/Annurev-Pathol-011811-132427  0.359
2005 Crouch ML, Becker LA, Bang IS, Tanabe H, Ouellette AJ, Fang FC. The alternative sigma factor sigma is required for resistance of Salmonella enterica serovar Typhimurium to anti-microbial peptides. Molecular Microbiology. 56: 789-99. PMID 15819632 DOI: 10.1111/J.1365-2958.2005.04578.X  0.346
2005 Tanabe H, Ayabe T, Bainbridge B, Guina T, Ernst RK, Darveau RP, Miller SI, Ouellette AJ. Mouse paneth cell secretory responses to cell surface glycolipids of virulent and attenuated pathogenic bacteria. Infection and Immunity. 73: 2312-20. PMID 15784576 DOI: 10.1128/Iai.73.4.2312-2320.2005  0.448
2004 Ouellette AJ. Defensin-mediated innate immunity in the small intestine. Best Practice & Research. Clinical Gastroenterology. 18: 405-19. PMID 15123078 DOI: 10.1016/J.Bpg.2003.10.010  0.475
2004 Lin PW, Simon PO, Gewirtz AT, Neish AS, Ouellette AJ, Madara JL, Lencer WI. Paneth cell cryptdins act in vitro as apical paracrine regulators of the innate inflammatory response. The Journal of Biological Chemistry. 279: 19902-7. PMID 14990585 DOI: 10.1074/Jbc.M311821200  0.404
2004 Tanabe H, Yuan J, Zaragoza MM, Dandekar S, Henschen-Edman A, Selsted ME, Ouellette AJ. Paneth cell alpha-defensins from rhesus macaque small intestine. Infection and Immunity. 72: 1470-8. PMID 14977952 DOI: 10.1128/Iai.72.3.1470-1478.2004  0.46
2004 Clarke LL, Gawenis LR, Bradford EM, Judd LM, Boyle KT, Simpson JE, Shull GE, Tanabe H, Ouellette AJ, Franklin CL, Walker NM. Abnormal Paneth cell granule dissolution and compromised resistance to bacterial colonization in the intestine of CF mice. American Journal of Physiology. Gastrointestinal and Liver Physiology. 286: G1050-8. PMID 14715526 DOI: 10.1152/Ajpgi.00393.2003  0.433
2004 Tanabe H, Qu X, Weeks CS, Cummings JE, Kolusheva S, Walsh KB, Jelinek R, Vanderlick TK, Selsted ME, Ouellette AJ. Structure-activity determinants in paneth cell alpha-defensins: loss-of-function in mouse cryptdin-4 by charge-reversal at arginine residue positions. The Journal of Biological Chemistry. 279: 11976-83. PMID 14702345 DOI: 10.1074/Jbc.M310251200  0.455
2004 Lin PW, Simon PO, Gewirtz AT, Neish AS, Ouellette AJ, Madara JL, Lencer WI. 191 PANETH CELL CRYPTDINS ARE APICAL PARACRINE REGULATORS OF THE INNATE INTESTINAL INFLAMMATORY RESPONSE. Journal of Investigative Medicine. 52: S291.3-S291. DOI: 10.1136/Jim-52-Suppl1-744  0.366
2003 Satchell DP, Sheynis T, Kolusheva S, Cummings J, Vanderlick TK, Jelinek R, Selsted ME, Ouellette AJ. Quantitative interactions between cryptdin-4 amino terminal variants and membranes. Peptides. 24: 1795-805. PMID 15019212 DOI: 10.1016/J.Peptides.2003.08.020  0.451
2003 Shirafuji Y, Tanabe H, Satchell DP, Henschen-Edman A, Wilson CL, Ouellette AJ. Structural determinants of procryptdin recognition and cleavage by matrix metalloproteinase-7. The Journal of Biological Chemistry. 278: 7910-9. PMID 12482850 DOI: 10.1074/Jbc.M210600200  0.385
2003 Cummings JE, Satchell DP, Shirqfuji Y, Ouellette AJ, Vanderlick TK. Electrostatically Controlled Interactions of Mouse Paneth Cell α-Defensins with Phospholipid Membranes Australian Journal of Chemistry. 56: 1031-1034. DOI: 10.1071/Ch03110  0.408
2003 Ayabe T, Maemoto A, Miyoshi Y, Ashida T, Saitoh Y, Kono T, Ebisawa Y, Ouellette AJ, Kohgo Y. The role of human intestinal paneth cells expressing toll-like receptors in innate host defense Gastroenterology. 124: A45. DOI: 10.1016/S0016-5085(03)80220-2  0.412
2002 Ayabe T, Satchell DP, Pesendorfer P, Tanabe H, Wilson CL, Hagen SJ, Ouellette AJ. Activation of Paneth cell alpha-defensins in mouse small intestine. The Journal of Biological Chemistry. 277: 5219-28. PMID 11733520 DOI: 10.1074/Jbc.M109410200  0.492
2002 Ayabe T, Wulff H, Darmoul D, Cahalan MD, Chandy KG, Ouellette AJ. Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel. The Journal of Biological Chemistry. 277: 3793-800. PMID 11724775 DOI: 10.1074/Jbc.M107507200  0.443
2001 Ouellette AJ, Bevins CL. Paneth cell defensins and innate immunity of the small bowel. Inflammatory Bowel Diseases. 7: 43-50. PMID 11233660 DOI: 10.1097/00054725-200102000-00007  0.347
2001 Kamal M, Wakelin D, Smith A, Ouellette A, Podolsky D, Mahida Y. Thymus-Independent Mucosal T Cells Regulate the Increase in Paneth and Intermediate Cells in the Small Intestine of Mice Infected with T. Spiralis Clinical Science. 100: 13P-14P. DOI: 10.1042/Cs100013Pc  0.328
2001 Ayabe T, Maemoto A, Ashida T, Orii F, Miyoshi K, Fujiya K, Fujiya M, Watari J, Saitoh Y, Kono T, Ouellette AJ, Kohgo Y. Functional studies of colonic paneth cells in patients with ulcertive colitis Gastroenterology. 120: A524. DOI: 10.1016/S0016-5085(08)82605-4  0.32
2001 Ayabe T, Satchell DP, Tanabe H, Hagen SJ, Wilson CL, Ouellette AJ. Processing and activation of α-delensins in mouse intestinal paneth cells Gastroenterology. 120: A187. DOI: 10.1016/S0016-5085(08)80926-2  0.374
2001 Simon PO, Lin P, Gerwitz AT, Merlin D, Satchell DP, Selsted ME, Ouellette AJ, Madara JL, Lencer WI. The paneth cell α-defensin cryptdin 3 induces a Ca2+-dependent secretion of IL-8 in model intestinal epithelia Gastroenterology. 120: A22. DOI: 10.1016/S0016-5085(08)80107-2  0.3
2001 Alnadjim Z, Cohn SM, Ayabe T, Biafora S, Ouellette A, Barrett TA. T cell activation instructs epithelial lineage development by inducing paneth cell expansion and cryptdin production in intestinal crypts Gastroenterology. 120: A21. DOI: 10.1016/S0016-5085(08)80104-7  0.355
2000 Ayabe T, Satchell DP, Wilson CL, Parks WC, Selsted ME, Ouellette AJ. Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nature Immunology. 1: 113-8. PMID 11248802 DOI: 10.1038/77783  0.501
2000 Ouellette AJ, Satchell DP, Hsieh MM, Hagen SJ, Selsted ME. Characterization of luminal Paneth cell α-defensins in mouse small intestine: Attenuated antimicrobial activities of peptides with truncated amino termini Journal of Biological Chemistry. 275: 33969-33973. PMID 10942762 DOI: 10.1074/jbc.M004062200  0.378
2000 Ayabe T, Satchell DP, Wilson CL, Parks WC, Selsted ME, Ouellette AJ. Mouse paneth cell secretory responses to in vitro microbial infection Gastroenterology. 118: A695. DOI: 10.1016/S0016-5085(00)84911-2  0.331
2000 Ayabe T, Ghanshani S, Chandy KG, Darmoul D, Ouellette AJ. The calcium-activated potassium channel, mIKCa1, is paneth cell-specific in mouse small intestinal epithelium and functions in the secretory response Gastroenterology. 118: A96. DOI: 10.1016/S0016-5085(00)82463-4  0.32
1999 Ouellette AJ, Darmoul D, Tran D, Huttner KM, Yuan J, Selsted ME. Peptide localization and gene structure of cryptdin 4, a differentially expressed mouse Paneth cell α-defensin Infection and Immunity. 67: 6643-6651. PMID 10569786 DOI: 10.1128/Iai.67.12.6643-6651.1999  0.397
1999 Tang YQ, Yuan J, Ösapay G, Ösapay K, Tran D, Miller CJ, Ouellette AJ, Selsted ME. A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated α-defensins Science. 286: 498-502. PMID 10521339 DOI: 10.1126/Science.286.5439.498  0.437
1999 Wilson CL, Ouellette AJ, Satchell DP, Ayabe T, López-Boado YS, Stratman JL, Hultgren SJ, Matrisian LM, Parks WC. Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense. Science (New York, N.Y.). 286: 113-7. PMID 10506557 DOI: 10.1126/Science.286.5437.113  0.474
1999 Ouellette AJ. Mucosal immunity and inflammation. IV. Paneth cell antimicrobial peptides and the biology of the mucosal barrier American Journal of Physiology - Gastrointestinal and Liver Physiology. 277. PMID 10444437 DOI: 10.1152/Ajpgi.1999.277.2.G257  0.498
1997 Ouellette AJ. Paneth cells and innate immunity in the crypt microenvironment Gastroenterology. 113: 1779-1784. PMID 9352884 DOI: 10.1053/Gast.1997.V113.Pm9352884  0.487
1997 Lencer WI, Cheung G, Strohmeier GR, Currie MG, Ouellette AJ, Selsted ME, Madara JL. Induction of epithelial chloride secretion by channel-forming cryptdins 2 and 3. Proceedings of the National Academy of Sciences of the United States of America. 94: 8585-9. PMID 9238020 DOI: 10.1073/Pnas.94.16.8585  0.433
1997 Darmoul D, Brown D, Selsted ME, Ouellette AJ. Cryptdin gene expression in developing mouse small intestine American Journal of Physiology - Gastrointestinal and Liver Physiology. 272. PMID 9038894 DOI: 10.1152/Ajpgi.1997.272.1.G197  0.412
1997 Ouellette AJ, Selsted ME. Enteric defensins Current Opinion in Gastroenterology. 13: 494-499.  0.402
1996 Ouellette AJ, Selsted ME. Paneth cell defensins: Endogenous peptide components of intestinal host defense Faseb Journal. 10: 1280-1289. PMID 8836041 DOI: 10.1096/Fasebj.10.11.8836041  0.514
1996 Darmoul D, Ouellette AJ. Positional specificity of defensin gene expression reveals Paneth cell heterogeneity in mouse small intestine American Journal of Physiology - Gastrointestinal and Liver Physiology. 271. PMID 8760109 DOI: 10.1152/Ajpgi.1996.271.1.G68  0.405
1995 Selsted ME, Ouellette AJ. Defensins in granules of phagocytic and non-phagocytic cells Trends in Cell Biology. 5: 114-119. DOI: 10.1016/S0962-8924(00)88961-8  0.477
1994 Huttner KM, Selsted ME, Ouellette AJ. Structure and Diversity of the Murine Cryptdin Gene Family Genomics. 19: 448-453. PMID 8188287 DOI: 10.1006/Geno.1994.1093  0.362
1994 Bry L, Falk P, Huttner K, Ouellette A, Midtvedt T, Gordon JI. Paneth cell differentiation in the developing intestine of normal and transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 91: 10335-9. PMID 7937951 DOI: 10.1073/Pnas.91.22.10335  0.404
1994 Ouellette AJ, Hsieh MM, Nosek MT, Cano-Gauci DF, Huttner KM, Buick RN, Selsted ME. Mouse Paneth cell defensins: Primary structures and antibacterial activities of numerous cryptdin isoforms Infection and Immunity. 62: 5040-5047. PMID 7927786 DOI: 10.1128/Iai.62.11.5040-5047.1994  0.467
1994 Huttner KM, Ouellette AJ. A family of defensin-like genes codes for diverse cysteine-rich peptides in mouse Paneth cells Genomics. 24: 99-109. PMID 7896294 DOI: 10.1006/Geno.1994.1586  0.382
1993 Cano-Gauci DF, Lualdi JC, Ouellette AJ, Brady G, Iscove NN, Buick RN. In vitro cDNA amplification from individual intestinal crypts: A novel approach to the study of differential gene expression along the crypt-villus axis Experimental Cell Research. 208: 344-349. PMID 7690709 DOI: 10.1006/Excr.1993.1255  0.365
1992 Ouellette AJ, Miller SI, Henschen AH, Selsted ME. Purification and primary structure of murine cryptdin-1, a Paneth cell defensin Febs Letters. 304: 146-148. PMID 1618314 DOI: 10.1016/0014-5793(92)80606-H  0.438
1992 Selsted ME, Miller SI, Henschen AH, Ouellette AJ. Enteric defensins: Antibiotic peptide components of intestinal host defense Journal of Cell Biology. 118: 929-936. PMID 1500431 DOI: 10.1083/Jcb.118.4.929  0.475
1992 Lin MY, Munshi IA, Ouellette AJ. The defensin-related murine CRS1C gene: Expression in paneth cells and linkage to Defcr, the cryptdin locus Genomics. 14: 363-368. PMID 1427853 DOI: 10.1016/S0888-7543(05)80227-7  0.322
1989 Ouellette AJ, Greco RM, James M, Frederick D, Naftilan J, Fallon JT. Developmental regulation of cryptdin, a corticostatin/defensin precursor mRNA in mouse small intestinal crypt epithelium. The Journal of Cell Biology. 108: 1687-95. PMID 2715173 DOI: 10.1083/Jcb.108.5.1687  0.389
1988 Ouellette AJ, Cordell B. Accumulation of abundant messenger ribonucleic acids during postnatal development of mouse small intestine Gastroenterology. 94: 114-121. PMID 3335283 DOI: 10.1016/0016-5085(88)90618-X  0.313
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