Douglas W. DeSimone - Publications

Affiliations: 
Cell Biology University of Virginia, Charlottesville, VA 
Area:
Human Development, Cell Biology

69 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Watanabe H, Belyea BC, Paxton RL, Li M, Dzamba BJ, DeSimone DW, Gomez RA, Sequeira-Lopez MLS. The Renin Cell Baroreceptor, A Nuclear Mechanotransducer Central for Homeostasis. Circulation Research. PMID 33993729 DOI: 10.1161/CIRCRESAHA.120.318711  1
2018 Dzamba BJ, DeSimone DW. Extracellular Matrix (ECM) and the Sculpting of Embryonic Tissues. Current Topics in Developmental Biology. 130: 245-274. PMID 29853179 DOI: 10.1016/Bs.Ctdb.2018.03.006  1
2017 Sonavane PR, Wang C, Dzamba B, Weber GF, Periasamy A, DeSimone DW. Mechanical and signaling roles for keratin intermediate filaments in the assembly and morphogenesis of mesendoderm tissue at gastrulation. Development (Cambridge, England). PMID 28982683 DOI: 10.1242/Dev.155200  1
2014 Rozario T, Mead PE, DeSimone DW. Diverse functions of kindlin/fermitin proteins during embryonic development in Xenopus laevis. Mechanisms of Development. 133: 203-17. PMID 25173804 DOI: 10.1016/J.Mod.2014.07.004  1
2014 DeSimone DW, Horwitz AR. Cell Biology. Many modes of motility. Science (New York, N.Y.). 345: 1002-3. PMID 25170137 DOI: 10.1126/Science.1259176  1
2014 Bjerke MA, Dzamba BJ, Wang C, DeSimone DW. FAK is required for tension-dependent organization of collective cell movements in Xenopus mesendoderm. Developmental Biology. 394: 340-56. PMID 25127991 DOI: 10.1016/J.Ydbio.2014.07.023  1
2012 Xu G, Wei S, White JM, DeSimone DW. Identification and characterization of ADAM41, a novel ADAM metalloproteinase in Xenopus. The International Journal of Developmental Biology. 56: 333-9. PMID 22811267 DOI: 10.1387/Ijdb.113444Gx  1
2012 Batra N, Burra S, Siller-Jackson AJ, Gu S, Xia X, Weber GF, DeSimone D, Bonewald LF, Lafer EM, Sprague E, Schwartz MA, Jiang JX. Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels. Proceedings of the National Academy of Sciences of the United States of America. 109: 3359-64. PMID 22331870 DOI: 10.1073/Pnas.1115967109  1
2012 Wei S, Xu G, Bridges LC, Williams P, Nakayama T, Shah A, Grainger RM, White JM, DeSimone DW. Roles of ADAM13-regulated Wnt activity in early Xenopus eye development. Developmental Biology. 363: 147-54. PMID 22227340 DOI: 10.1016/J.Ydbio.2011.12.031  1
2012 Weber GF, Bjerke MA, DeSimone DW. A mechanoresponsive cadherin-keratin complex directs polarized protrusive behavior and collective cell migration. Developmental Cell. 22: 104-15. PMID 22169071 DOI: 10.1016/J.Devcel.2011.10.013  1
2012 Lallier T, Hens MD, DeSimone DW. Integrins in Development Integrins: Molecular and Biological Responses to the Extracellular Matrix. 111-140. DOI: 10.1016/B978-0-08-091729-0.50010-3  1
2011 Schwarzbauer JE, DeSimone DW. Fibronectins, their fibrillogenesis, and in vivo functions. Cold Spring Harbor Perspectives in Biology. 3. PMID 21576254 DOI: 10.1101/Cshperspect.A005041  1
2011 Weber GF, Bjerke MA, DeSimone DW. Integrins and cadherins join forces to form adhesive networks. Journal of Cell Science. 124: 1183-93. PMID 21444749 DOI: 10.1242/Jcs.064618  1
2011 Weber G, Bjerke MA, DeSimone DW. Erratum: Integrins and cadherins join forces to form adhesive networks Journal of Cell Science. 124. DOI: 10.1242/Jcs.091074  1
2010 Wei S, Xu G, Bridges LC, Williams P, White JM, DeSimone DW. ADAM13 induces cranial neural crest by cleaving class B Ephrins and regulating Wnt signaling. Developmental Cell. 19: 345-52. PMID 20708595 DOI: 10.1016/J.Devcel.2010.07.012  1
2010 Wei S, Whittaker CA, Xu G, Bridges LC, Shah A, White JM, Desimone DW. Conservation and divergence of ADAM family proteins in the Xenopus genome. Bmc Evolutionary Biology. 10: 211. PMID 20630080 DOI: 10.1186/1471-2148-10-211  1
2010 Rozario T, DeSimone DW. The extracellular matrix in development and morphogenesis: a dynamic view. Developmental Biology. 341: 126-40. PMID 19854168 DOI: 10.1016/J.Ydbio.2009.10.026  1
2009 Dzamba BJ, Jakab KR, Marsden M, Schwartz MA, DeSimone DW. Cadherin adhesion, tissue tension, and noncanonical Wnt signaling regulate fibronectin matrix organization. Developmental Cell. 16: 421-32. PMID 19289087 DOI: 10.1016/J.Devcel.2009.01.008  1
2009 Rozario T, Dzamba B, Weber GF, Davidson LA, DeSimone DW. The physical state of fibronectin matrix differentially regulates morphogenetic movements in vivo. Developmental Biology. 327: 386-98. PMID 19138684 DOI: 10.1016/J.Ydbio.2008.12.025  1
2008 Davidson LA, Dzamba BD, Keller R, Desimone DW. Live imaging of cell protrusive activity, and extracellular matrix assembly and remodeling during morphogenesis in the frog, Xenopus laevis. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 237: 2684-92. PMID 18629871 DOI: 10.1002/Dvdy.21600  1
2008 Schwartz MA, DeSimone DW. Cell adhesion receptors in mechanotransduction. Current Opinion in Cell Biology. 20: 551-6. PMID 18583124 DOI: 10.1016/J.Ceb.2008.05.005  1
2008 Cousin H, Desimone DW, Alfandari D. PACSIN2 regulates cell adhesion during gastrulation in Xenopus laevis. Developmental Biology. 319: 86-99. PMID 18495106 DOI: 10.1016/J.Ydbio.2008.04.007  1
2007 Thorne BC, Bailey AM, DeSimone DW, Peirce SM. Agent-based modeling of multicell morphogenic processes during development. Birth Defects Research. Part C, Embryo Today : Reviews. 81: 344-53. PMID 18228259 DOI: 10.1002/Bdrc.20106  1
2007 Robertson SH, Smith CK, Langhans AL, McLinden SE, Oberhardt MA, Jakab KR, Dzamba B, DeSimone DW, Papin JA, Peirce SM. Multiscale computational analysis of Xenopus laevis morphogenesis reveals key insights of systems-level behavior. Bmc Systems Biology. 1: 46. PMID 17953751 DOI: 10.1186/1752-0509-1-46  1
2007 DeSimone DW, Dzamba B, Davidson LA. Using Xenopus embryos to investigate integrin function. Methods in Enzymology. 426: 403-14. PMID 17697893 DOI: 10.1016/S0076-6879(07)26017-3  1
2006 Davidson LA, Marsden M, Keller R, Desimone DW. Integrin alpha5beta1 and fibronectin regulate polarized cell protrusions required for Xenopus convergence and extension. Current Biology : Cb. 16: 833-44. PMID 16682346 DOI: 10.1016/J.Cub.2006.03.038  1
2005 DeSimone DW, Davidson L, Marsden M, Alfandari D. The Xenopus embryo as a model system for studies of cell migration. Methods in Molecular Biology (Clifton, N.J.). 294: 235-45. PMID 15576916 DOI: 10.1385/1-59259-860-9:235  1
2004 Davidson LA, Keller R, DeSimone DW. Assembly and remodeling of the fibrillar fibronectin extracellular matrix during gastrulation and neurulation in Xenopus laevis. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 231: 888-95. PMID 15517579 DOI: 10.1002/Dvdy.20217  1
2004 Longo D, Peirce SM, Skalak TC, Davidson L, Marsden M, Dzamba B, DeSimone DW. Multicellular computer simulation of morphogenesis: blastocoel roof thinning and matrix assembly in Xenopus laevis. Developmental Biology. 271: 210-22. PMID 15196962 DOI: 10.1016/J.Ydbio.2004.03.021  1
2004 Davidson LA, Keller R, DeSimone D. Patterning and tissue movements in a novel explant preparation of the marginal zone of Xenopus laevis. Gene Expression Patterns : Gep. 4: 457-66. PMID 15183313 DOI: 10.1016/J.Modgep.2004.01.001  1
2003 Alfandari D, Cousin H, Gaultier A, Hoffstrom BG, DeSimone DW. Integrin alpha5beta1 supports the migration of Xenopus cranial neural crest on fibronectin. Developmental Biology. 260: 449-64. PMID 12921745 DOI: 10.1016/S0012-1606(03)00277-X  1
2003 Marsden M, DeSimone DW. Integrin-ECM interactions regulate cadherin-dependent cell adhesion and are required for convergent extension in Xenopus. Current Biology : Cb. 13: 1182-91. PMID 12867028 DOI: 10.1016/S0960-9822(03)00433-0  1
2003 Na J, Marsden M, DeSimone DW. Differential regulation of cell adhesive functions by integrin alpha subunit cytoplasmic tails in vivo. Journal of Cell Science. 116: 2333-43. PMID 12711704 DOI: 10.1242/Jcs.00445  1
2002 Smith KM, Gaultier A, Cousin H, Alfandari D, White JM, DeSimone DW. The cysteine-rich domain regulates ADAM protease function in vivo. The Journal of Cell Biology. 159: 893-902. PMID 12460986 DOI: 10.1083/Jcb.200206023  1
2002 Davidson LA, Hoffstrom BG, Keller R, DeSimone DW. Mesendoderm extension and mantle closure in Xenopus laevis gastrulation: combined roles for integrin alpha(5)beta(1), fibronectin, and tissue geometry. Developmental Biology. 242: 109-29. PMID 11820810 DOI: 10.1006/Dbio.2002.0537  1
2001 Marsden M, DeSimone DW. Regulation of cell polarity, radial intercalation and epiboly in Xenopus: Novel roles for integrin and fibronectin Development. 128: 3635-3647. PMID 11566866  1
2001 Alfandari D, Cousin H, Gaultier A, Smith K, White JM, Darribère T, DeSimone DW. Xenopus ADAM 13 is a metalloprotease required for cranial neural crest-cell migration Current Biology. 11: 918-930. PMID 11448768 DOI: 10.1016/S0960-9822(01)00263-9  1
2000 Lallier TE, DeSimone DW. Separation of neural induction and neurulation in xenopus Developmental Biology. 225: 135-150. PMID 10964470 DOI: 10.1006/Dbio.2000.9833  1
2000 Cohen MW, Hoffstrom BG, DeSimone DW. Active zones on motor nerve terminals contain alpha 3beta 1 integrin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 4912-21. PMID 10864949  1
1998 Whittaker CA, Desimone DW. Molecular cloning and developmental expression of the Xenopus homolog of integrin α4a Annals of the New York Academy of Sciences. 857: 56-73. PMID 9917832 DOI: 10.1111/J.1749-6632.1998.Tb10107.X  1
1998 Urry LA, Whittaker CA, Duquette M, Lawler J, DeSimone DW. Thrombospondins in early Xenopus embryos: Dynamic patterns of expression suggest diverse roles in nervous system, notochord, and muscle development Developmental Dynamics. 211: 390-407. PMID 9566958 DOI: 10.1002/(Sici)1097-0177(199804)211:4<390::Aid-Aja10>3.0.Co;2-8  1
1997 Meng F, Whittaker CA, Ransom DG, DeSimone DW. Cloning and characterization of cDNAs encoding the integrin α2 and α3 subunits from Xenopus laevis Mechanisms of Development. 67: 141-155. PMID 9392512 DOI: 10.1016/S0925-4773(97)00108-1  1
1997 Alfandari D, Wolfsberg TG, White JM, DeSimone DW. ADAM 13: A novel ADAM expressed in somitic mesoderm and neural crest cells during Xenopus laevis development Developmental Biology. 182: 314-330. PMID 9070330 DOI: 10.1006/Dbio.1996.8458  1
1997 Desimone DW, Ramos JW, Hoffstromi EG, Kateeshock SJ, Hens MD. Spatial regulation of integr1n adhesive function in early development Faseb Journal. 11.  1
1996 Alfandari D, Ramos J, Clavilier L, DeSimone DW, Darribère T. The RGD-dependent and the Hep II binding domains of fibronectin govern the adhesive behaviors of amphibian embryonic cells Mechanisms of Development. 56: 83-92. PMID 8798149 DOI: 10.1016/0925-4773(96)00513-8  1
1996 Ramos JW, Whittaker CA, DeSimone DW. Integrin-dependent adhesive activity is spatially controlled by inductive signals at gastrulation Development. 122: 2873-2883. PMID 8787760  1
1996 Lallier TE, Whittaker CA, DeSimone DW. Integrin α6 expression is required for early nervous system development in Xenopus laevis Development. 122: 2539-2554. PMID 8756298  1
1996 Ramos JW, DeSimone DW. Xenopus embryonic cell adhesion to fibronectin: Position-specific activation of RGD/synergy site-dependent migratory behavior at gastrulation Journal of Cell Biology. 134: 227-240. PMID 8698817 DOI: 10.1083/Jcb.134.1.227  1
1995 Hens MD, DeSimone DW. Molecular analysis and developmental expression of the focal adhesion kinase pp125FAK in Xenopus laevis Developmental Biology. 170: 274-288. PMID 7649362 DOI: 10.1006/Dbio.1995.1214  1
1995 Alfandari D, Whittaker CA, Desimone DW, Darribère T. Integrin αv subunit is expressed on mesodermal cell surfaces during amphibian gastrulation Developmental Biology. 170: 249-261. PMID 7649360 DOI: 10.1006/Dbio.1995.1212  1
1995 Joos TO, Whittaker CA, Meng F, DeSimone DW, Gnau V, Hausen P. Integrin α5 during early development of Xenopus laevis Mechanisms of Development. 50: 187-199. PMID 7619730 DOI: 10.1016/0925-4773(94)00335-K  1
1994 DeSimone DW. Adhesion and matrix in vertebrate development Current Opinion in Cell Biology. 6: 747-751. PMID 7833054 DOI: 10.1016/0955-0674(94)90103-1  1
1993 Lawler J, Duquette M, Whittaker CA, Adams JC, McHenry K, DeSimone DW. Identification and characterization of thrombospondin-4, a new member of the thrombospondin gene family Journal of Cell Biology. 120: 1059-1067. PMID 8432726 DOI: 10.1083/Jcb.120.4.1059  1
1993 Whittaker CA, DeSimone DW. Integrin α subunit mRNAs are differentially expressed in early Xenopus embryos Development. 117: 1239-1249. PMID 8404528  1
1993 Clavilier L, Riou JF, De Shi L, Desimone DW, Boucaut JC. Amphibian pleurodeles waltl fibronectin: CDNA cloning and developmental expression of spliced variants Cell Communication and Adhesion. 1: 83-91. PMID 8081872 DOI: 10.3109/15419069309095683  1
1993 Ransom DG, Hens MD, DeSimone DW. Integrin expression in early amphibian embryos: CDNA cloning and characterization of Xenopus β1, β2, β3, and β6 subunits Developmental Biology. 160: 265-275. PMID 7693527 DOI: 10.1006/Dbio.1993.1304  1
1992 DeSimone DW, Norton PA, Hynes RO. Identification and characterization of alternatively spliced fibronectin mRNAs expressed in early Xenopus embryos Developmental Biology. 149: 357-369. PMID 1730390 DOI: 10.1016/0012-1606(92)90291-N  1
1992 Shi DL, Feige JJ, Riou JF, DeSimone DW, Boucaut JC. Differential expression and regulation of two distinct fibroblast growth factor receptors during early development of the urodele amphibian Pleurodeles waltl Development. 116: 261-273. PMID 1483392  1
1992 Johnson KE, Boucaut JC, DeSimone DW. Role of the extracellular matrix in amphibian gastrulation Current Topics in Developmental Biology. 27: 91-127. PMID 1424768 DOI: 10.1016/S0070-2153(08)60533-5  1
1991 Desimone DW, Johnson KE. Chapter 27 The Xenopus Embryo as a Model System for the Study of Cell-Extracellular Matrix Interactions Methods in Cell Biology. 36: 527-539. PMID 1811150 DOI: 10.1016/S0091-679X(08)60295-2  1
1988 DeSimone DW, Hynes RO. Xenopus laevis integrins. Structural conservation and evolutionary divergence of integrin β subunits Journal of Biological Chemistry. 263: 5333-5340. PMID 2833505  1
1987 DeSimone DW, Stepp MA, Patel RS, Hynes RO. The integrin family of cell surface receptors Biochemical Society Transactions. 15: 789-791. PMID 2826269 DOI: 10.1042/Bst0150789A  1
1986 DeSimone DW, Spiegel M. Concanavalin A and wheat germ agglutinin binding to sea urchin embryo basal laminae. Roux's Archives of Developmental Biology : the Official Organ of the Edbo. 195: 433-444. PMID 28305405 DOI: 10.1007/BF00375747  1
1986 Tamkun JW, DeSimone DW, Fonda D, Patel RS, Buck C, Horwitz AF, Hynes RO. Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin. Cell. 46: 271-82. PMID 3487386 DOI: 10.1016/0092-8674(86)90744-0  1
1986 DeSimone DW, Spiegel M. Wheat germ agglutinin binding to the micromeres and primary mesenchyme cells of sea urchin embryos Developmental Biology. 114: 336-346. DOI: 10.1016/0012-1606(86)90198-3  1
1986 DeSimone DW, Spiegel M. Concanavalin A and wheat germ agglutinin binding to sea urchin embryo basal laminae Roux's Archives of Developmental Biology. 195: 433-444. DOI: 10.1007/BF00375747  1
1985 DeSimone DW, Spiegel E, Spiegel M. The biochemical identification of fibronectin in the sea urchin embryo Biochemical and Biophysical Research Communications. 133: 183-188. PMID 4074361 DOI: 10.1016/0006-291X(85)91858-3  1
1980 Muggleton-Harris AL, DeSimone DW. Replicative potentials of various fusion products between WI-38 and SV40 transformed WI-38 cells and their components Somatic Cell Genetics. 6: 689-698. PMID 6255618 DOI: 10.1007/BF01538968  1
1979 Robinson HL, Pearson MN, DeSimone DW, Tsichlis PN, Coffin JM. Subgroup-E avian-leukosis-virus-associated disease in chickens Symposia On Quantitative Biology. 44: 1133-1142. PMID 6253188 DOI: 10.1101/Sqb.1980.044.01.122  1
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