Philip B. Wedegaertner - Publications

Affiliations: 
Biochemistry and Molecular Biology Thomas Jefferson University 
Area:
Biochemistry, Cell Biology

48 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Helms MC, Grabocka E, Martz MK, Fischer CC, Suzuki N, Wedegaertner PB. Mitotic-dependent phosphorylation of leukemia-associated RhoGEF (LARG) by Cdk1. Cellular Signalling. 28: 43-52. PMID 26483157 DOI: 10.1016/j.cellsig.2015.10.004  0.32
2015 Hewavitharana T, Wedegaertner PB. PAQR3 regulates Golgi vesicle fission and transport via the Gβγ-PKD signaling pathway. Cellular Signalling. 27: 2444-51. PMID 26327583 DOI: 10.1016/j.cellsig.2015.08.017  0.32
2015 Malik S, deRubio RG, Trembley M, Irannejad R, Wedegaertner PB, Smrcka AV. G protein βγ subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway. Molecular Biology of the Cell. 26: 1188-98. PMID 25609085 DOI: 10.1091/mbc.E14-10-1476  0.32
2014 Xu H, Jiang X, Shen K, Fischer CC, Wedegaertner PB. The regulator of G protein signaling (RGS) domain of G protein-coupled receptor kinase 5 (GRK5) regulates plasma membrane localization and function. Molecular Biology of the Cell. 25: 2105-15. PMID 24807909 DOI: 10.1091/mbc.E13-09-0547  0.32
2013 Martz MK, Grabocka E, Beeharry N, Yen TJ, Wedegaertner PB. Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission. Molecular Biology of the Cell. 24: 2785-94. PMID 23885121 DOI: 10.1091/mbc.E12-07-0533  0.32
2012 Wedegaertner PB. G protein trafficking. Sub-Cellular Biochemistry. 63: 193-223. PMID 23161140 DOI: 10.1007/978-94-007-4765-4_11  0.32
2012 Hewavitharana T, Wedegaertner PB. Non-canonical signaling and localizations of heterotrimeric G proteins. Cellular Signalling. 24: 25-34. PMID 21907280 DOI: 10.1016/j.cellsig.2011.08.014  0.32
2010 Irannejad R, Wedegaertner PB. Regulation of constitutive cargo transport from the trans-Golgi network to plasma membrane by Golgi-localized G protein betagamma subunits. The Journal of Biological Chemistry. 285: 32393-404. PMID 20720014 DOI: 10.1074/jbc.M110.154963  0.32
2010 Crouthamel M, Abankwa D, Zhang L, DiLizio C, Manning DR, Hancock JF, Wedegaertner PB. An N-terminal polybasic motif of Gαq is required for signaling and influences membrane nanodomain distribution. Molecular Pharmacology. 78: 767-77. PMID 20664004 DOI: 10.1124/mol.110.066340  0.32
2010 Wedegaertner PB. Reversible palmitoylation in g protein signaling Handbook of Cell Signaling, 2/E. 2: 1713-1720. DOI: 10.1016/B978-0-12-374145-5.00208-4  0.32
2009 Banerjee J, Fischer CC, Wedegaertner PB. The amino acid motif L/IIxxFE defines a novel actin-binding sequence in PDZ-RhoGEF. Biochemistry. 48: 8032-43. PMID 19618964 DOI: 10.1021/bi9010013  0.32
2009 Bhattacharyya R, Banerjee J, Khalili K, Wedegaertner PB. Differences in Galpha12- and Galpha13-mediated plasma membrane recruitment of p115-RhoGEF. Cellular Signalling. 21: 996-1006. PMID 19249348 DOI: 10.1016/j.cellsig.2009.02.010  0.32
2008 Crouthamel M, Thiyagarajan MM, Evanko DS, Wedegaertner PB. N-terminal polybasic motifs are required for plasma membrane localization of Galpha(s) and Galpha(q). Cellular Signalling. 20: 1900-10. PMID 18647648 DOI: 10.1016/j.cellsig.2008.06.019  0.32
2008 Iwanicki MP, Vomastek T, Tilghman RW, Martin KH, Banerjee J, Wedegaertner PB, Parsons JT. FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts. Journal of Cell Science. 121: 895-905. PMID 18303050 DOI: 10.1242/jcs.020941  0.32
2007 Grabocka E, Wedegaertner PB. Disruption of oligomerization induces nucleocytoplasmic shuttling of leukemia-associated rho Guanine-nucleotide exchange factor. Molecular Pharmacology. 72: 993-1002. PMID 17609419 DOI: 10.1124/mol.107.035162  0.32
2007 Marrari Y, Crouthamel M, Irannejad R, Wedegaertner PB. Assembly and trafficking of heterotrimeric G proteins. Biochemistry. 46: 7665-77. PMID 17559193 DOI: 10.1021/bi700338m  0.32
2007 Jiang X, Benovic JL, Wedegaertner PB. Plasma membrane and nuclear localization of G protein coupled receptor kinase 6A. Molecular Biology of the Cell. 18: 2960-9. PMID 17538017 DOI: 10.1091/mbc.E07-01-0013  0.32
2007 Escribá PV, Wedegaertner PB, Goñi FM, Vögler O. Lipid-protein interactions in GPCR-associated signaling. Biochimica Et Biophysica Acta. 1768: 836-52. PMID 17067547 DOI: 10.1016/j.bbamem.2006.09.001  0.32
2005 Billington CK, Kong KC, Bhattacharyya R, Wedegaertner PB, Panettieri RA, Chan TO, Penn RB. Cooperative regulation of p70S6 kinase by receptor tyrosine kinases and G protein-coupled receptors augments airway smooth muscle growth. Biochemistry. 44: 14595-605. PMID 16262259 DOI: 10.1021/bi0510734  0.32
2005 Evanko DS, Thiyagarajan MM, Takida S, Wedegaertner PB. Loss of association between activated Galpha q and Gbetagamma disrupts receptor-dependent and receptor-independent signaling. Cellular Signalling. 17: 1218-28. PMID 16038796 DOI: 10.1016/j.cellsig.2004.12.008  0.32
2005 Grabocka E, Wedegaertner PB. Functional consequences of G alpha 13 mutations that disrupt interaction with p115RhoGEF. Oncogene. 24: 2155-65. PMID 15735747 DOI: 10.1038/sj.onc.1208414  0.32
2005 Takida S, Fischer CC, Wedegaertner PB. Palmitoylation and plasma membrane targeting of RGS7 are promoted by alpha o. Molecular Pharmacology. 67: 132-9. PMID 15496508 DOI: 10.1124/mol.104.003418  0.32
2004 Day PW, Wedegaertner PB, Benovic JL. Analysis of G-protein-coupled receptor kinase RGS homology domains. Methods in Enzymology. 390: 295-310. PMID 15488185 DOI: 10.1016/S0076-6879(04)90019-5  0.32
2004 Day PW, Tesmer JJ, Sterne-Marr R, Freeman LC, Benovic JL, Wedegaertner PB. Characterization of the GRK2 binding site of Galphaq. The Journal of Biological Chemistry. 279: 53643-52. PMID 15471870 DOI: 10.1074/jbc.M401438200  0.32
2004 Takida S, Wedegaertner PB. Exocytic pathway-independent plasma membrane targeting of heterotrimeric G proteins. Febs Letters. 567: 209-13. PMID 15178324 DOI: 10.1016/j.febslet.2004.04.062  0.32
2004 Thiyagarajan MM, Stracquatanio RP, Pronin AN, Evanko DS, Benovic JL, Wedegaertner PB. A predicted amphipathic helix mediates plasma membrane localization of GRK5. The Journal of Biological Chemistry. 279: 17989-95. PMID 14976207 DOI: 10.1074/jbc.M310738200  0.32
2004 Banerjee J, Wedegaertner PB. Identification of a novel sequence in PDZ-RhoGEF that mediates interaction with the actin cytoskeleton. Molecular Biology of the Cell. 15: 1760-75. PMID 14742719 DOI: 10.1091/mbc.E03-07-0527  0.32
2003 Day PW, Carman CV, Sterne-Marr R, Benovic JL, Wedegaertner PB. Differential interaction of GRK2 with members of the G alpha q family. Biochemistry. 42: 9176-84. PMID 12885252 DOI: 10.1021/bi034442+  0.32
2003 Bhattacharyya R, Wedegaertner PB. Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment. Febs Letters. 540: 211-6. PMID 12681510 DOI: 10.1016/S0014-5793(03)00267-9  0.32
2003 Takida S, Wedegaertner PB. Heterotrimer formation, together with isoprenylation, is required for plasma membrane targeting of Gbetagamma. The Journal of Biological Chemistry. 278: 17284-90. PMID 12609996 DOI: 10.1074/jbc.M213239200  0.32
2003 Bhattacharyya R, Wedegaertner PB. Characterization of G alpha 13-dependent plasma membrane recruitment of p115RhoGEF. The Biochemical Journal. 371: 709-20. PMID 12534370 DOI: 10.1042/BJ20021897  0.32
2003 Sterne-Marr R, Tesmer JJ, Day PW, Stracquatanio RP, Cilente JA, O'Connor KE, Pronin AN, Benovic JL, Wedegaertner PB. G protein-coupled receptor Kinase 2/G alpha q/11 interaction. A novel surface on a regulator of G protein signaling homology domain for binding G alpha subunits. The Journal of Biological Chemistry. 278: 6050-8. PMID 12427730 DOI: 10.1074/jbc.M208787200  0.32
2002 Thiyagarajan MM, Bigras E, Van Tol HH, Hébert TE, Evanko DS, Wedegaertner PB. Activation-induced subcellular redistribution of G alpha(s) is dependent upon its unique N-terminus. Biochemistry. 41: 9470-84. PMID 12135370 DOI: 10.1021/bi025533u  0.32
2002 Wedegaertner PB. Characterization of subcellular localization and stability of a splice variant of G alpha i2. Bmc Cell Biology. 3: 12. PMID 12057015  0.32
2002 Wedegaertner PB. Characterization of subcellular localization and stability of a splice variant of G alphai2 Bmc Cell Biology. 3. DOI: 10.1186/1471-2121-3-12  0.32
2001 Evanko DS, Thiyagarajan MM, Siderovski DP, Wedegaertner PB. Gβγ Isoforms Selectively Rescue Plasma Membrane Localization and Palmitoylation of Mutant Gαs and Gαq Journal of Biological Chemistry. 276: 23945-23953. PMID 11294873 DOI: 10.1074/jbc.M101154200  0.32
2000 Bhattacharyya R, Wedegaertner PB. Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding. The Journal of Biological Chemistry. 275: 14992-9. PMID 10747909 DOI: 10.1074/jbc.M000415200  0.32
2000 Evanko DS, Thiyagarajan MM, Wedegaertner PB. Interaction with Gβγ is required for membrane targeting and palmitoylation of Gα(s) and Gα(q) Journal of Biological Chemistry. 275: 1327-1336. PMID 10625681 DOI: 10.1074/jbc.275.2.1327  0.32
1999 Carman CV, Parent JL, Day PW, Pronin AN, Sternweis PM, Wedegaertner PB, Gilman AG, Benovic JL, Kozasa T. Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2. The Journal of Biological Chemistry. 274: 34483-92. PMID 10567430 DOI: 10.1074/jbc.274.48.34483  0.32
1998 Wedegaertner PB. Lipid modifications and membrane targeting of G(α) Biological Signals and Receptors. 7: 125-135. PMID 9629464  0.32
1996 Iiri T, Backlund PS, Jones TL, Wedegaertner PB, Bourne HR. Reciprocal regulation of Gs alpha by palmitate and the beta gamma subunit. Proceedings of the National Academy of Sciences of the United States of America. 93: 14592-7. PMID 8962097  0.32
1996 Wedegaertner PB, Bourne HR, von Zastrow M. Activation-induced subcellular redistribution of Gs alpha. Molecular Biology of the Cell. 7: 1225-33. PMID 8856666  0.32
1995 Wedegaertner PB, Wilson PT, Bourne HR. Lipid modifications of trimeric G proteins. The Journal of Biological Chemistry. 270: 503-6. PMID 7822269 DOI: 10.1074/jbc.270.2.503  0.32
1994 Wedegaertner PB, Bourne HR. Activation and depalmitoylation of Gs alpha. Cell. 77: 1063-70. PMID 7912657  0.32
1993 Wedegaertner PB, Chu DH, Wilson PT, Levis MJ, Bourne HR. Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha. The Journal of Biological Chemistry. 268: 25001-8. PMID 8227063  0.32
1992 Wedegaertner PB, Gill GN. Effect of carboxyl terminal truncation on the tyrosine kinase activity of the epidermal growth factor receptor Archives of Biochemistry and Biophysics. 292: 273-280. PMID 1309297 DOI: 10.1016/0003-9861(92)90079-C  0.32
1990 Nishibe S, Wahl MI, Wedegaertner PB, Kim JJ, Rhee SG, Carpenter G. Selectivity of phospholipase C phosphorylation by the epidermal growth factor receptor, the insulin receptor, and their cytoplasmic domains Proceedings of the National Academy of Sciences of the United States of America. 87: 424-428. PMID 2153302  0.32
1989 Wedegaertner PB, Gill GN. Activation of the purified protein tyrosine kinase domain of the epidermal growth factor receptor Journal of Biological Chemistry. 264: 11346-11353. PMID 2661557  0.32
Show low-probability matches.