Thomas D. Hurley - Publications

Affiliations: 
Biochemistry and Molecular Biology Indiana University, Bloomington, Bloomington, IN, United States 
Area:
Molecular Biology, Biochemistry

99 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Chefetz I, Grimley E, Yang K, Hong L, Vinogradova EV, Suciu R, Kovalenko I, Karnak D, Morgan CA, Chtcherbinine M, Buchman C, Huddle B, Barraza S, Morgan M, Bernstein KA, ... ... Hurley TD, et al. A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells. Cell Reports. 26: 3061-3075.e6. PMID 30865894 DOI: 10.1016/j.celrep.2019.02.032  0.44
2018 Huddle BC, Grimley E, Buchman CD, Chtcherbinine M, Debnath B, Mehta P, Yang K, Morgan CA, Li S, Felton JA, Sun D, Metha G, Neamati N, Buckanovich RJ, Hurley TD, et al. Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy. Journal of Medicinal Chemistry. PMID 30221940 DOI: 10.1021/acs.jmedchem.8b00930  0.44
2017 Buchman CD, Hurley TD. Inhibition of the Aldehyde Dehydrogenase 1/2 Family by Psoralen and Coumarin Derivatives. Journal of Medicinal Chemistry. PMID 28219011 DOI: 10.1021/acs.jmedchem.6b01825  0.44
2016 Mahalingan KK, Baskaran S, Depaoli-Roach AA, Roach PJ, Hurley TD. Redox switch for the inhibited state of yeast glycogen synthase mimics regulation by phosphorylation. Biochemistry. PMID 27935293 DOI: 10.1021/acs.biochem.6b00884  0.96
2016 Contreras CJ, Segvich DM, Mahalingan K, Chikwana VM, Kirley TL, Hurley TD, DePaoli-Roach AA, Roach PJ. Incorporation of phosphate into glycogen by glycogen synthase. Archives of Biochemistry and Biophysics. PMID 27036853 DOI: 10.1016/j.abb.2016.03.020  0.48
2015 Buchman CD, Mahalingan KK, Hurley TD. Discovery of a series of aromatic lactones as ALDH1/2-directed inhibitors. Chemico-Biological Interactions. 234: 38-44. PMID 25641190 DOI: 10.1016/j.cbi.2014.12.038  1
2015 Morgan CA, Hurley TD. Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors. Journal of Medicinal Chemistry. 58: 1964-75. PMID 25634381 DOI: 10.1021/jm501900s  1
2015 Morgan CA, Parajuli B, Buchman CD, Dria K, Hurley TD. N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes. Chemico-Biological Interactions. 234: 18-28. PMID 25512087 DOI: 10.1016/j.cbi.2014.12.008  1
2015 Carrigan MA, Uryasev O, Frye CB, Eckman BL, Myers CR, Hurley TD, Benner SA. Hominids adapted to metabolize ethanol long before human-directed fermentation. Proceedings of the National Academy of Sciences of the United States of America. 112: 458-63. PMID 25453080 DOI: 10.1073/pnas.1404167111  1
2015 Morgan CA, Hurley TD. Development of a high-throughput in vitro assay to identify selective inhibitors for human ALDH1A1. Chemico-Biological Interactions. 234: 29-37. PMID 25450233 DOI: 10.1016/j.cbi.2014.10.028  1
2015 Condello S, Morgan CA, Nagdas S, Cao L, Turek J, Hurley TD, Matei D. β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids. Oncogene. 34: 2297-308. PMID 24954508 DOI: 10.1038/onc.2014.178  1
2015 Chikwana VM, Khanna M, Baskaran S, Tagliabracci VS, Contreras CJ, DePaoli-Roach A, Roach PJ, Hurley TD. Correction: Structural basis for 2′-phosphate incorporation into glycogen by glycogen synthase (Proceedings of the National Academy of Sciences of the United States of America (2013) 110, 52 (20976-20981) DOI: 10.1073/pnas.1310106111) Proceedings of the National Academy of Sciences of the United States of America. 112: E2264. DOI: 10.1073/pnas.1506041112  1
2014 Wang B, Buchman CD, Li L, Hurley TD, Meroueh SO. Enrichment of chemical libraries docked to protein conformational ensembles and application to aldehyde dehydrogenase 2. Journal of Chemical Information and Modeling. 54: 2105-16. PMID 24856086 DOI: 10.1021/ci5002026  1
2014 Parajuli B, Georgiadis TM, Fishel ML, Hurley TD. Development of selective inhibitors for human aldehyde dehydrogenase 3A1 (ALDH3A1) for the enhancement of cyclophosphamide cytotoxicity. Chembiochem : a European Journal of Chemical Biology. 15: 701-12. PMID 24677340 DOI: 10.1002/cbic.201300625  1
2014 Kimble-Hill AC, Parajuli B, Chen CH, Mochly-Rosen D, Hurley TD. Development of selective inhibitors for aldehyde dehydrogenases based on substituted indole-2,3-diones. Journal of Medicinal Chemistry. 57: 714-22. PMID 24444054 DOI: 10.1021/jm401377v  1
2014 Parajuli B, Fishel ML, Hurley TD. Selective ALDH3A1 inhibition by benzimidazole analogues increase mafosfamide sensitivity in cancer cells. Journal of Medicinal Chemistry. 57: 449-61. PMID 24387105 DOI: 10.1021/jm401508p  1
2013 Chikwana VM, Khanna M, Baskaran S, Tagliabracci VS, Contreras CJ, DePaoli-Roach A, Roach PJ, Hurley TD. Structural basis for 2'-phosphate incorporation into glycogen by glycogen synthase. Proceedings of the National Academy of Sciences of the United States of America. 110: 20976-81. PMID 24324135 DOI: 10.1073/pnas.1310106111  1
2013 Wang B, Li L, Hurley TD, Meroueh SO. Molecular recognition in a diverse set of protein-ligand interactions studied with molecular dynamics simulations and end-point free energy calculations. Journal of Chemical Information and Modeling. 53: 2659-70. PMID 24032517 DOI: 10.1021/ci400312v  1
2013 Akin BL, Hurley TD, Chen Z, Jones LR. The structural basis for phospholamban inhibition of the calcium pump in sarcoplasmic reticulum. The Journal of Biological Chemistry. 288: 30181-91. PMID 23996003 DOI: 10.1074/jbc.M113.501585  1
2013 Khanna M, Imasaki T, Chikwana VM, Perez-Miller S, Hunter GO, Mosley A, Takagi Y, Hurley TD. Expression and purification of functional human glycogen synthase-1 (hGYS1) in insect cells. Protein Expression and Purification. 90: 78-83. PMID 23711380 DOI: 10.1016/j.pep.2013.05.007  1
2013 González-Segura L, Ho KK, Perez-Miller S, Weiner H, Hurley TD. Catalytic contribution of threonine 244 in human ALDH2. Chemico-Biological Interactions. 202: 32-40. PMID 23295226 DOI: 10.1016/j.cbi.2012.12.009  1
2012 Hurley TD, Edenberg HJ. Genes encoding enzymes involved in ethanol metabolism. Alcohol Research : Current Reviews. 34: 339-44. PMID 23134050  1
2012 Carrigan MA, Uryasev O, Davis RP, Zhai L, Hurley TD, Benner SA. The natural history of class I primate alcohol dehydrogenases includes gene duplication, gene loss, and gene conversion. Plos One. 7: e41175. PMID 22859968 DOI: 10.1371/journal.pone.0041175  1
2012 Koppaka V, Thompson DC, Chen Y, Ellermann M, Nicolaou KC, Juvonen RO, Petersen D, Deitrich RA, Hurley TD, Vasiliou V. Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application. Pharmacological Reviews. 64: 520-39. PMID 22544865 DOI: 10.1124/pr.111.005538  1
2012 Roach PJ, Depaoli-Roach AA, Hurley TD, Tagliabracci VS. Glycogen and its metabolism: some new developments and old themes. The Biochemical Journal. 441: 763-87. PMID 22248338 DOI: 10.1042/BJ20111416  1
2011 Khanna M, Chen CH, Kimble-Hill A, Parajuli B, Perez-Miller S, Baskaran S, Kim J, Dria K, Vasiliou V, Mochly-Rosen D, Hurley TD. Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases. The Journal of Biological Chemistry. 286: 43486-94. PMID 22021038 DOI: 10.1074/jbc.M111.293597  1
2011 Baskaran S, Chikwana VM, Contreras CJ, Davis KD, Wilson WA, DePaoli-Roach AA, Roach PJ, Hurley TD. Multiple glycogen-binding sites in eukaryotic glycogen synthase are required for high catalytic efficiency toward glycogen. The Journal of Biological Chemistry. 286: 33999-4006. PMID 21835915 DOI: 10.1074/jbc.M111.264531  1
2011 Liu JY, Hurley TD. A new crystal form of mouse thiamin pyrophosphokinase. International Journal of Biochemistry and Molecular Biology. 2: 111-8. PMID 21552434  1
2011 Tagliabracci VS, Heiss C, Karthik C, Contreras CJ, Glushka J, Ishihara M, Azadi P, Hurley TD, DePaoli-Roach AA, Roach PJ. Phosphate incorporation during glycogen synthesis and Lafora disease. Cell Metabolism. 13: 274-82. PMID 21356517 DOI: 10.1016/j.cmet.2011.01.017  1
2011 Parajuli B, Kimble-Hill AC, Khanna M, Ivanova Y, Meroueh S, Hurley TD. Discovery of novel regulators of aldehyde dehydrogenase isoenzymes. Chemico-Biological Interactions. 191: 153-8. PMID 21349255 DOI: 10.1016/j.cbi.2011.02.018  1
2010 Allen EM, Anderson DG, Florang VR, Khanna M, Hurley TD, Doorn JA. Relative inhibitory potency of molinate and metabolites with aldehyde dehydrogenase 2: implications for the mechanism of enzyme inhibition. Chemical Research in Toxicology. 23: 1843-50. PMID 20954713 DOI: 10.1021/tx100317q  1
2010 Baskaran S, Roach PJ, DePaoli-Roach AA, Hurley TD. Structural basis for glucose-6-phosphate activation of glycogen synthase. Proceedings of the National Academy of Sciences of the United States of America. 107: 17563-8. PMID 20876143 DOI: 10.1073/pnas.1006340107  1
2010 Perez-Miller S, Zou Q, Novotny MV, Hurley TD. High resolution X-ray structures of mouse major urinary protein nasal isoform in complex with pheromones. Protein Science : a Publication of the Protein Society. 19: 1469-79. PMID 20509168 DOI: 10.1002/pro.426  1
2010 Perez-Miller S, Younus H, Vanam R, Chen CH, Mochly-Rosen D, Hurley TD. Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant. Nature Structural & Molecular Biology. 17: 159-64. PMID 20062057 DOI: 10.1038/nsmb.1737  1
2010 Baraibar MA, Muhoberac BB, Garringer HJ, Hurley TD, Vidal R. Unraveling of the E-helices and disruption of 4-fold pores are associated with iron mishandling in a mutant ferritin causing neurodegeneration. The Journal of Biological Chemistry. 285: 1950-6. PMID 19923220 DOI: 10.1074/jbc.M109.042986  1
2009 Aneetha H, O'Dell DK, Tan B, Walker JM, Hurley TD. Alcohol dehydrogenase-catalyzed in vitro oxidation of anandamide to N-arachidonoyl glycine, a lipid mediator: synthesis of N-acyl glycinals. Bioorganic & Medicinal Chemistry Letters. 19: 237-41. PMID 19013794 DOI: 10.1016/j.bmcl.2008.10.087  1
2008 Chen CH, Budas GR, Churchill EN, Disatnik MH, Hurley TD, Mochly-Rosen D. Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science (New York, N.Y.). 321: 1493-5. PMID 18787169 DOI: 10.1126/science.1158554  1
2008 Wang WL, Chai SC, Huang M, He HZ, Hurley TD, Ye QZ. Discovery of inhibitors of Escherichia coli methionine aminopeptidase with the Fe(II)-form selectivity and antibacterial activity. Journal of Medicinal Chemistry. 51: 6110-20. PMID 18785729 DOI: 10.1021/jm8005788  1
2007 Ma ZQ, Xie SX, Huang QQ, Nan FJ, Hurley TD, Ye QZ. Structural analysis of inhibition of E. coli methionine aminopeptidase: implication of loop adaptability in selective inhibition of bacterial enzymes. Bmc Structural Biology. 7: 84. PMID 18093325 DOI: 10.1186/1472-6807-7-84  1
2007 Janecki DJ, Bemis KG, Tegeler TJ, Sanghani PC, Zhai L, Hurley TD, Bosron WF, Wang M. A multiple reaction monitoring method for absolute quantification of the human liver alcohol dehydrogenase ADH1C1 isoenzyme. Analytical Biochemistry. 369: 18-26. PMID 17692277 DOI: 10.1016/j.ab.2007.06.043  1
2007 Hurley TD, Yang J, Zhang L, Goodwin KD, Zou Q, Cortese M, Dunker AK, DePaoli-Roach AA. Structural basis for regulation of protein phosphatase 1 by inhibitor-2. The Journal of Biological Chemistry. 282: 28874-83. PMID 17636256 DOI: 10.1074/jbc.M703472200  1
2007 Larson HN, Zhou J, Chen Z, Stamler JS, Weiner H, Hurley TD. Structural and functional consequences of coenzyme binding to the inactive asian variant of mitochondrial aldehyde dehydrogenase: roles of residues 475 and 487. The Journal of Biological Chemistry. 282: 12940-50. PMID 17327228 DOI: 10.1074/jbc.M607959200  1
2007 Florang VR, Rees JN, Brogden NK, Anderson DG, Hurley TD, Doorn JA. Inhibition of the oxidative metabolism of 3,4-dihydroxyphenylacetaldehyde, a reactive intermediate of dopamine metabolism, by 4-hydroxy-2-nonenal. Neurotoxicology. 28: 76-82. PMID 16956664 DOI: 10.1016/j.neuro.2006.07.018  1
2006 Hurley TD, Walls C, Bennett JR, Roach PJ, Wang M. Direct detection of glycogenin reaction products during glycogen initiation. Biochemical and Biophysical Research Communications. 348: 374-8. PMID 16889748 DOI: 10.1016/j.bbrc.2006.07.106  1
2006 Ho KK, Hurley TD, Weiner H. Selective alteration of the rate-limiting step in cytosolic aldehyde dehydrogenase through random mutagenesis. Biochemistry. 45: 9445-53. PMID 16878979 DOI: 10.1021/bi060718c  1
2006 Doorn JA, Hurley TD, Petersen DR. Inhibition of human mitochondrial aldehyde dehydrogenase by 4-hydroxynon-2-enal and 4-oxonon-2-enal. Chemical Research in Toxicology. 19: 102-10. PMID 16411662 DOI: 10.1021/tx0501839  1
2006 Liu JY, Timm DE, Hurley TD. Pyrithiamine as a substrate for thiamine pyrophosphokinase. The Journal of Biological Chemistry. 281: 6601-7. PMID 16365036 DOI: 10.1074/jbc.M510951200  1
2005 Larson HN, Weiner H, Hurley TD. Disruption of the coenzyme binding site and dimer interface revealed in the crystal structure of mitochondrial aldehyde dehydrogenase "Asian" variant. The Journal of Biological Chemistry. 280: 30550-6. PMID 15983043 DOI: 10.1074/jbc.M502345200  1
2005 Ho KK, Allali-Hassani A, Hurley TD, Weiner H. Differential effects of Mg2+ ions on the individual kinetic steps of human cytosolic and mitochondrial aldehyde dehydrogenases. Biochemistry. 44: 8022-9. PMID 15924421 DOI: 10.1021/bi050038u  1
2005 Hurley TD, Stout S, Miner E, Zhou J, Roach PJ. Requirements for catalysis in mammalian glycogenin. The Journal of Biological Chemistry. 280: 23892-9. PMID 15849187 DOI: 10.1074/jbc.M502344200  1
2005 Quinney SK, Sanghani SP, Davis WI, Hurley TD, Sun Z, Murry DJ, Bosron WF. Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide. The Journal of Pharmacology and Experimental Therapeutics. 313: 1011-6. PMID 15687373 DOI: 10.1124/jpet.104.081265  1
2004 Gibbons BJ, Hurley TD. Structure of three class I human alcohol dehydrogenases complexed with isoenzyme specific formamide inhibitors. Biochemistry. 43: 12555-62. PMID 15449945 DOI: 10.1021/bi0489107  1
2004 Fukunaga AK, Marsh S, Murry DJ, Hurley TD, McLeod HL. Identification and analysis of single-nucleotide polymorphisms in the gemcitabine pharmacologic pathway. The Pharmacogenomics Journal. 4: 307-14. PMID 15224082 DOI: 10.1038/sj.tpj.6500259  1
2004 Sun Z, Murry DJ, Sanghani SP, Davis WI, Kedishvili NY, Zou Q, Hurley TD, Bosron WF. Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1. The Journal of Pharmacology and Experimental Therapeutics. 310: 469-76. PMID 15082749 DOI: 10.1124/jpet.104.067116  1
2003 Perez-Miller SJ, Hurley TD. Coenzyme isomerization is integral to catalysis in aldehyde dehydrogenase. Biochemistry. 42: 7100-9. PMID 12795606 DOI: 10.1021/bi034182w  1
2003 Sanghani PC, Robinson H, Bennett-Lovsey R, Hurley TD, Bosron WF. Structure-function relationships in human Class III alcohol dehydrogenase (formaldehyde dehydrogenase). Chemico-Biological Interactions. 143: 195-200. PMID 12604204 DOI: 10.1016/S0009-2797(02)00203-X  1
2002 Sanghani PC, Bosron WF, Hurley TD. Human glutathione-dependent formaldehyde dehydrogenase. Structural changes associated with ternary complex formation. Biochemistry. 41: 15189-94. PMID 12484756 DOI: 10.1021/bi026705q  1
2002 Sanghani PC, Robinson H, Bosron WF, Hurley TD. Human glutathione-dependent formaldehyde dehydrogenase. Structures of apo, binary, and inhibitory ternary complexes. Biochemistry. 41: 10778-86. PMID 12196016 DOI: 10.1021/bi0257639  1
2002 Gibbons BJ, Roach PJ, Hurley TD. Crystal structure of the autocatalytic initiator of glycogen biosynthesis, glycogenin. Journal of Molecular Biology. 319: 463-77. PMID 12051921 DOI: 10.1016/S0022-2836(02)00305-4  1
2002 Hammen PK, Allali-Hassani A, Hallenga K, Hurley TD, Weiner H. Multiple conformations of NAD and NADH when bound to human cytosolic and mitochondrial aldehyde dehydrogenase. Biochemistry. 41: 7156-68. PMID 12033950 DOI: 10.1021/bi012197t  1
2002 Bosron WF, Hurley TD. Lessons from a bacterial cocaine esterase. Nature Structural Biology. 9: 4-5. PMID 11753424 DOI: 10.1038/nsb0102-4  1
2001 Hurley TD, Perez-Miller S, Breen H. Order and disorder in mitochondrial aldehyde dehydrogenase Chemico-Biological Interactions. 130: 3-14. PMID 11306026 DOI: 10.1016/S0009-2797(00)00217-9  1
2001 Niederhut MS, Gibbons BJ, Perez-Miller S, Hurley TD. Three-dimensional structures of the three human class I alcohol dehydrogenases. Protein Science : a Publication of the Protein Society. 10: 697-706. PMID 11274460 DOI: 10.1110/ps.45001  1
2000 Sanghani PC, Stone CL, Ray BD, Pindel EV, Hurley TD, Bosron WF. Kinetic mechanism of human glutathione-dependent formaldehyde dehydrogenase Biochemistry. 39: 10720-10729. PMID 10978156 DOI: 10.1021/bi9929711  1
2000 Wei B, Ni L, Hurley TD, Weiner H. Cooperativity in nicotinamide adenine dinucleotide binding induced by mutations of arginine 475 located at the subunit interface in the human liver mitochondrial class 2 aldehyde dehydrogenase Biochemistry. 39: 5295-5302. PMID 10819999 DOI: 10.1021/bi000028n  1
2000 Yang J, Hurley TD, DePaoli-Roach AA. Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase: Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif Journal of Biological Chemistry. 275: 22635-22644. PMID 10807923 DOI: 10.1074/jbc.M003082200  1
1999 Ni L, Zhou J, Hurley TD, Weiner H. Human liver mitochondrial aldehyde dehydrogenase: three-dimensional structure and the restoration of solubility and activity of chimeric forms. Protein Science : a Publication of the Protein Society. 8: 2784-90. PMID 10631996 DOI: 10.1110/ps.8.12.2784  1
1999 Xie PT, Hurley TD. Methionine-141 directly influences the binding of 4-methylpyrazole in human σσ alcohol dehydrogenase Protein Science. 8: 2639-2644. PMID 10631979  1
1999 Hurley TD, Weiner H. Evaluation of the roles of the conserved residues of aldehyde dehydrogenase Advances in Experimental Medicine and Biology. 463: 45-52. PMID 10352668  1
1999 Hurley TD, Steinmetz CG, Weiner H. Three-dimensional structure of mitochondrial aldehyde dehydrogenase: Mechanistic implications Advances in Experimental Medicine and Biology. 463: 15-25. PMID 10352665  1
1999 Stone CL, Jipping MB, Owusu-Dekyi K, Hurley TD, Li TK, Bosron WF. The pH-dependent binding of NADH and subsequent enzyme isomerization of human liver β3β3 alcohol dehydrogenase Biochemistry. 38: 5829-5835. PMID 10231534 DOI: 10.1021/bi982944v  1
1999 Hodes ME, Zimmerman AW, Aydanian A, Naidu S, Miller NR, Garcia Oller JL, Barker B, Aleck KA, Hurley TD, Dlouhy SR. Different mutations in the same codon of the proteolipid protein gene, PLP, may help in correlating genotype with phenotype in Pelizaeus-Merzbacher disease/X-linked spastic paraplegia (PMD/SPG2) American Journal of Medical Genetics. 82: 132-139. PMID 9934976 DOI: 10.1002/(SICI)1096-8628(19990115)82:2<132::AID-AJMG6>3.0.CO;2-4  1
1998 Longenecker KL, Roach PJ, Hurley TD. Crystallographic studies of casein kinase I δ: Toward a structural understanding of auto-inhibition Acta Crystallographica Section D: Biological Crystallography. 54: 473-475. PMID 9761932 DOI: 10.1107/S0907444997011724  1
1997 Harris RA, Hawes JW, Popov KM, Zhao Y, Shimomura Y, Sato J, Jaskiewicz J, Hurley TD. Studies on the regulation of the mitochondrial α-ketoacid dehydrogenase complexes and their kinases Advances in Enzyme Regulation. 37: 271-293. PMID 9381974 DOI: 10.1016/S0065-2571(96)00009-X  1
1997 Sheikh S, Ni L, Hurley TD, Weiner H. The potential roles of the conserved amino acids in human liver mitochondrial aldehyde dehydrogenase Journal of Biological Chemistry. 272: 18817-18822. PMID 9228056 DOI: 10.1074/jbc.272.30.18817  1
1997 Xie P, Parsons SH, Speckhard DC, Bosron WF, Hurley TD. X-ray structure of human class IV σσ alcohol dehydrogenase. Structural basis for substrate specificity Journal of Biological Chemistry. 272: 18558-18563. PMID 9228021 DOI: 10.1074/jbc.272.30.18558  1
1997 Steinmetz CG, Xie P, Weiner H, Hurley TD. Structure of mitochondrial aldehyde dehydrogenase: The genetic component of ethanol aversion Structure. 5: 701-711. PMID 9195888  1
1997 Hurley TD, Steinmetz CG, Xie P, Yang ZN. Three-dimensional structures of human alcohol dehydrogenase isoenzymes reveal the molecular basis for their functional diversity Advances in Experimental Medicine and Biology. 414: 291-302. PMID 9059633  1
1997 Kedishvili NY, Gough WH, Chernoff EA, Hurley TD, Stone CL, Bowman KD, Popov KM, Bosron WF, Li TK. cDNA sequence and catalytic properties of a chick embryo alcohol dehydrogenase that oxidizes retinol and 3beta,5alpha-hydroxysteroids. The Journal of Biological Chemistry. 272: 7494-500. PMID 9054452 DOI: 10.1074/jbc.272.11.7494  1
1997 Yang ZN, Bosron WF, Hurley TD. Structure of human χχ alcohol dehydrogenase: A glutathione-dependent formaldehyde dehydrogenase Journal of Molecular Biology. 265: 330-343. PMID 9018047 DOI: 10.1006/jmbi.1996.0731  1
1996 Davis GJ, Bosron WF, Stone CL, Owusu-Dekyi K, Hurley TD. X-ray structure of human β3β3 alcohol dehydrogenase. The contribution of ionic interactions to coenzyme binding Journal of Biological Chemistry. 271: 17057-17061. PMID 8663387 DOI: 10.1074/jbc.271.29.17057  1
1996 Longenecker KL, Roach PJ, Hurley TD. Three-dimensional structure of mammalian casein kinase I: Molecular basis for phosphate recognition Journal of Molecular Biology. 257: 618-631. PMID 8648628 DOI: 10.1006/jmbi.1996.0189  1
1995 Kedishvili NY, Bosron WF, Stone CL, Hurley TD, Peggs CF, Thomasson HR, Popov KM, Carr LG, Edenberg HJ, Li TK. Expression and kinetic characterization of recombinant human stomach alcohol dehydrogenase: Active-site amino acid sequence explains substrate specificity compared with liver isozymes Journal of Biological Chemistry. 270: 3625-3630. PMID 7876099  1
1995 Stone CL, Hurley TD, Peggs CF, Kedishvili NY, Davis GJ, Thomasson HR, Li TK, Bosron WF. Cimetidine inhibition of human gastric and liver alcohol dehydrogenase isoenzymes: Identification of inhibitor complexes by kinetics and molecular modeling Biochemistry. 34: 4008-4014. PMID 7696266  1
1995 Kedishvili NY, Bosron WF, Stone CL, Peggs CF, Thomasson HR, Popov KM, Carr LG, Hurley TD, Edenberg HJ, Li TK. Cloning and expression of a human stomach alcohol dehydrogenase isozyme Advances in Experimental Medicine and Biology. 372: 341-347. PMID 7484396  1
1995 Hurley TD, Vessell DL. The role of leucine 116 in determining substrate specificity in human B1 alcohol dehydrogenase Advances in Experimental Medicine and Biology. 372: 321-325. PMID 7484393  1
1994 Davis GJ, Carr LG, Hurley TD, Li TK, Bosron WF. Comparative Roles of Histidine-51 in Human β1β1 and Threonine-51 in ππ Alcohol Dehydrogenases Archives of Biochemistry and Biophysics. 311: 307-312. PMID 8203892 DOI: 10.1006/abbi.1994.1242  1
1994 Hurley TD, Bosron WF, Stone CL, Amzel LM. Structures of three human beta alcohol dehydrogenase variants. Correlations with their functional differences. Journal of Molecular Biology. 239: 415-29. PMID 8201622 DOI: 10.1006/jmbi.1994.1382  1
1994 Yang ZN, Davis GJ, Hurley TD, Stone CL, Li TK, Bosron WF. Catalytic efficiency of human alcohol dehydrogenases for retinol oxidation and retinal reduction Alcoholism: Clinical and Experimental Research. 18: 587-591. PMID 7943659 DOI: 10.1111/j.1530-0277.1994.tb00914.x  1
1993 Hurley TD, Yang Z, Bosron WF, Weiner H. Crystallization and preliminary X-ray analysis of bovine mitochondrial aldehyde dehydrogenase and human glutathione-dependent formaldehyde dehydrogenase Advances in Experimental Medicine and Biology. 328: 245-250. PMID 8493900  1
1993 Stone CL, Hurley TD, Amzel LM, Dunn MF, Bosron WF. Kinetics of a glycine for Arg-47 human alcohol dehydrogenase mutant can be explained by Lys-228 recruitment into the pyrophosphate binding site. Advances in Experimental Medicine and Biology. 328: 429-37. PMID 8388156  1
1993 Hurley TD, Bosron WF, Mario Amzel L. Human alcohol dehydrogenase: Design of a secondary alcohol dehydrogenase using crystallography and mutagenesis Protein Engineering, Design and Selection. 6: 44. DOI: 10.1093/protein/6.Supplement.44-a  1
1992 Ehrig T, Muhoberac BB, Hurley TD, Bosron WF. Tryptophan fluorescence quenching by alkaline pH and ternary complex formation in human β1β1 and horse EE alcohol dehydrogenases Febs Letters. 300: 283-285. PMID 1555656 DOI: 10.1016/0014-5793(92)80864-D  1
1992 Hurley TD, Bosron WF. Human alcohol dehydrogenase: Dependence of secondary alcohol oxidation on the amino acids at positions 93 and 94 Biochemical and Biophysical Research Communications. 183: 93-99. PMID 1543513 DOI: 10.1016/0006-291X(92)91613-U  1
1992 Hurley TD, Weiner H. Crystallization and preliminary X-ray investigation of bovine liver mitochondrial aldehyde dehydrogenase Journal of Molecular Biology. 227: 1255-1257. PMID 1433298 DOI: 10.1016/0022-2836(92)90536-S  1
1991 Hurley TD, Ehrig T, Edenberg HJ, Bosron WF. Characterization of human alcohol dehydrogenases containing substitutions at amino acids 47 and 51 Advances in Experimental Medicine and Biology. 284: 271-275. PMID 2053482  1
1991 Ehrig T, Hurley TD, Edenberg HJ, Bosron WF. General Base Catalysis in a Glutamine for Histidine Mutant at Position 51 of Human Liver Alcohol Dehydrogenase Biochemistry. 30: 1062-1068. PMID 1989677  1
1991 Hurley TD, Bosron WF, Hamilton JA, Amzel LM. Structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic effects of non-active-site substitutions. Proceedings of the National Academy of Sciences of the United States of America. 88: 8149-53. PMID 1896463  1
1990 Hurley TD, Edenberg HJ, Bosron WF. Expression and kinetic characterization of variants of human β1β1 alcohol dehydrogenase containing substitutions at amino acid 47 Journal of Biological Chemistry. 265: 16366-16372. PMID 2398055  1
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