Peter Gargalovic, Ph.D. - Publications

2002 University of North Texas Health Science Center at Fort Worth 
Cell Biology, Immunology

35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Tora G, Jiang J, Bostwick JS, Gargalovic PS, Onorato JM, Luk CE, Generaux C, Xu C, Galella MA, Wang T, He Y, Wexler RR, Finlay HJ. Identification of 6-​Hydroxy-​5-​phenyl​sulfonylpyrimidin-​4(1H)​-​one APJ Receptor Agonists. Bioorganic & Medicinal Chemistry Letters. 128325. PMID 34403724 DOI: 10.1016/j.bmcl.2021.128325  1
2021 Johnson JA, Kim SH, Jiang J, Phillips M, Schumacher WA, Bostwick JS, Gargalovic PS, Onorato JM, Luk CE, Generaux C, He Y, Chen XQ, Xu C, Galella MA, Wang T, et al. Discovery of a Hydroxypyridinone APJ Receptor Agonist as a Clinical Candidate. Journal of Medicinal Chemistry. PMID 33689340 DOI: 10.1021/acs.jmedchem.0c01878  1
2021 Gargalovic P, Wong P, Onorato J, Finlay H, Wang T, Yan M, Crain E, St-Onge S, Héroux M, Bouvier M, Xu C, Chen XQ, Generaux C, Lawrence M, Wexler R, et al. In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure. Circulation. Heart Failure. CIRCHEARTFAILURE1200. PMID 33663236 DOI: 10.1161/CIRCHEARTFAILURE.120.007351  0.01
2020 Myers MC, Bilder DM, Cavallaro CL, Chao HJ, Su S, Burford NT, Nayeem A, Wang T, Yan M, Langish RA, Dabros M, Li YX, Rose AV, Behnia K, Onorato JM, ... Gargalovic PS, et al. Discovery and SAR of aryl hydroxy pyrimidinones as potent small molecule agonists of the GPCR APJ. Bioorganic & Medicinal Chemistry Letters. 126955. PMID 32035698 DOI: 10.1016/j.bmcl.2020.126955  1
2019 Su S, Clarke A, Han Y, Chao HJ, Bostwick J, Schumacher W, Wang T, Yan M, Hsu MY, Simmons E, Luk C, Xu C, Dabros M, Galella M, Onorato J, ... ... Gargalovic PS, et al. Biphenyl Acid Derivatives as APJ Receptor Agonists. Journal of Medicinal Chemistry. PMID 31724863 DOI: 10.1021/Acs.Jmedchem.9B01513  0.01
2018 Onorato JM, Xu C, Chen XQ, Rose AV, Generaux C, Lentz K, Shipkova P, Arthur S, Hennan JK, Haskell R, Myers MC, Lawrence RM, Finlay HJ, Basso M, Bostwick J, ... ... Gargalovic P, et al. Linking (Pyr)apelin-13 pharmacokinetics to efficacy: Stabilization and measurement of a high clearance peptide in rodents. Analytical Biochemistry. PMID 30605634 DOI: 10.1016/J.Ab.2018.12.022  1
2017 Civelek M, Wu Y, Pan C, Raulerson CK, Ko A, He A, Tilford C, Saleem NK, Stančáková A, Scott LJ, Fuchsberger C, Stringham HM, Jackson AU, Narisu N, Chines PS, ... ... Gargalovic PS, et al. Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits. American Journal of Human Genetics. 100: 428-443. PMID 28257690 DOI: 10.1016/J.Ajhg.2017.01.027  1
2016 Bennett BJ, Davis RC, Civelek M, Orozco L, Wu J, Qi H, Pan C, Sevag Packard RR, Eskin E, Yan M, Kirchgessner T, Wang Z, Li X, Gregory JC, Hazen SL, ... Gargalovic PS, et al. Correction: Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains. Plos Genetics. 12: e1005913. PMID 26934746 DOI: 10.1371/journal.pgen.1005913  1
2015 Bennett BJ, Davis RC, Civelek M, Orozco L, Wu J, Qi H, Pan C, Packard RR, Eskin E, Yan M, Kirchgessner T, Wang Z, Li X, Gregory JC, Hazen SL, ... Gargalovic PS, et al. Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains. Plos Genetics. 11: e1005711. PMID 26694027 DOI: 10.1371/Journal.Pgen.1005711  1
2015 Hui ST, Parks BW, Org E, Norheim F, Che N, Pan C, Castellani LW, Charugundla S, Dirks DL, Psychogios N, Neuhaus I, Gerszten RE, Kirchgessner T, Gargalovic PS, Lusis AJ. The genetic architecture of NAFLD among inbred strains of mice. Elife. 4. PMID 26067236 DOI: 10.7554/Elife.05607  1
2015 Parks BW, Sallam T, Mehrabian M, Psychogios N, Hui ST, Norheim F, Castellani LW, Rau CD, Pan C, Phun J, Zhou Z, Yang WP, Neuhaus I, Gargalovic PS, Kirchgessner TG, et al. Genetic architecture of insulin resistance in the mouse. Cell Metabolism. 21: 334-46. PMID 25651185 DOI: 10.1016/J.Cmet.2015.01.002  1
2014 Garcia RA, Yan M, Search D, Zhang R, Carson NL, Ryan CS, Smith-Monroy C, Zheng J, Chen J, Kong Y, Tang H, Hellings SE, Wardwell-Swanson J, Dinchuk JE, Psaltis GC, ... ... Gargalovic PS, et al. P2Y6 receptor potentiates pro-inflammatory responses in macrophages and exhibits differential roles in atherosclerotic lesion development. Plos One. 9: e111385. PMID 25360548 DOI: 10.1371/Journal.Pone.0111385  1
2013 Civelek M, Hagopian R, Pan C, Che N, Yang WP, Kayne PS, Saleem NK, Cederberg H, Kuusisto J, Gargalovic PS, Kirchgessner TG, Laakso M, Lusis AJ. Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits. Human Molecular Genetics. 22: 3023-37. PMID 23562819 DOI: 10.1093/Hmg/Ddt159  1
2013 García RA, Search DJ, Lupisella JA, Ostrowski J, Guan B, Chen J, Yang WP, Truong A, He A, Zhang R, Yan M, Hellings SE, Gargalovic PS, Ryan CS, Watson LM, et al. 11β-hydroxysteroid dehydrogenase type 1 gene knockout attenuates atherosclerosis and in vivo foam cell formation in hyperlipidemic apoE⁻/⁻ mice. Plos One. 8: e53192. PMID 23383297 DOI: 10.1371/journal.pone.0053192  1
2013 Parks BW, Nam E, Org E, Kostem E, Norheim F, Hui ST, Pan C, Civelek M, Rau CD, Bennett BJ, Mehrabian M, Ursell LK, He A, Castellani LW, Zinker B, ... ... Gargalovic P, et al. Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice. Cell Metabolism. 17: 141-52. PMID 23312289 DOI: 10.1016/J.Cmet.2012.12.007  1
2012 Orozco LD, Bennett BJ, Farber CR, Ghazalpour A, Pan C, Che N, Wen P, Qi HX, Mutukulu A, Siemers N, Neuhaus I, Yordanova R, Gargalovic P, Pellegrini M, Kirchgessner T, et al. Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages. Cell. 151: 658-70. PMID 23101632 DOI: 10.1016/J.Cell.2012.08.043  1
2012 Ghazalpour A, Rau CD, Farber CR, Bennett BJ, Orozco LD, van Nas A, Pan C, Allayee H, Beaven SW, Civelek M, Davis RC, Drake TA, Friedman RA, Furlotte N, Hui ST, ... ... Gargalovic PS, et al. Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 23: 680-92. PMID 22892838 DOI: 10.1007/S00335-012-9411-5  1
2012 Onorato JM, Langish R, Hellings S, Shipkova P, Gargalovic PS. Characterizing the lipid-loading properties of macrophages using LC/MS for the detection of cholesterol and cholesteryl-esters American Pharmaceutical Review. 15.  1
2011 Ghazalpour A, Bennett B, Petyuk VA, Orozco L, Hagopian R, Mungrue IN, Farber CR, Sinsheimer J, Kang HM, Furlotte N, Park CC, Wen PZ, Brewer H, Weitz K, Camp DG, ... ... Gargalovic P, et al. Comparative analysis of proteome and transcriptome variation in mouse. Plos Genetics. 7: e1001393. PMID 21695224 DOI: 10.1371/Journal.Pgen.1001393  1
2010 Romanoski CE, Lee S, Kim MJ, Ingram-Drake L, Plaisier CL, Yordanova R, Tilford C, Guan B, He A, Gargalovic PS, Kirchgessner TG, Berliner JA, Lusis AJ. Systems genetics analysis of gene-by-environment interactions in human cells. American Journal of Human Genetics. 86: 399-410. PMID 20170901 DOI: 10.1016/J.Ajhg.2010.02.002  1
2010 Gargalovic PS, Erbilgin A, Kohannim O, Pagnon J, Wang X, Castellani L, LeBoeuf R, Peterson ML, Spear BT, Lusis AJ. Quantitative trait locus mapping and identification of Zhx2 as a novel regulator of plasma lipid metabolism Circulation: Cardiovascular Genetics. 3: 60-67. PMID 20160197 DOI: 10.1161/Circgenetics.109.902320  1
2010 Bennett BJ, Farber CR, Orozco L, Kang HM, Ghazalpour A, Siemers N, Neubauer M, Neuhaus I, Yordanova R, Guan B, Truong A, Yang WP, He A, Kayne P, Gargalovic P, et al. A high-resolution association mapping panel for the dissection of complex traits in mice. Genome Research. 20: 281-90. PMID 20054062 DOI: 10.1101/Gr.099234.109  1
2009 Gargalovic PS. Atherogenesis on the chopping block. Cell Metabolism. 9: 399-401. PMID 19416707 DOI: 10.1016/j.cmet.2009.04.003  1
2009 Mungrue IN, Pagnon J, Kohannim O, Gargalovic PS, Lusis AJ. CHAC1/MGC4504 is a novel proapoptotic component of the unfolded protein response, downstream of the ATF4-ATF3-CHOP cascade. Journal of Immunology (Baltimore, Md. : 1950). 182: 466-76. PMID 19109178 DOI: 10.4049/Jimmunol.182.1.466  1
2008 Oskolkova OV, Afonyushkin T, Leitner A, von Schlieffen E, Gargalovic PS, Lusis AJ, Binder BR, Bochkov VN. ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein response. Blood. 112: 330-9. PMID 18451308 DOI: 10.1182/Blood-2007-09-112870  1
2007 Moen CJ, Tholens AP, Voshol PJ, de Haan W, Havekes LM, Gargalovic P, Lusis AJ, van Dyk KW, Frants RR, Hofker MH, Rensen PC. The Hyplip2 locus causes hypertriglyceridemia by decreased clearance of triglycerides. Journal of Lipid Research. 48: 2182-92. PMID 17609525 DOI: 10.1194/Jlr.M700009-Jlr200  1
2007 Gharavi NM, Gargalovic PS, Chang I, Araujo JA, Clark MJ, Szeto WL, Watson AD, Lusis AJ, Berliner JA. High-density lipoprotein modulates oxidized phospholipid signaling in human endothelial cells from proinflammatory to anti-inflammatory. Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 1346-53. PMID 17379837 DOI: 10.1161/Atvbaha.107.141283  1
2006 Gargalovic PS, Gharavi NM, Clark MJ, Pagnon J, Yang WP, He A, Truong A, Baruch-Oren T, Berliner JA, Kirchgessner TG, Lusis AJ. The unfolded protein response is an important regulator of inflammatory genes in endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 2490-6. PMID 16931790 DOI: 10.1161/01.Atv.0000242903.41158.A1  1
2006 Gargalovic PS, Imura M, Zhang B, Gharavi NM, Clark MJ, Pagnon J, Yang WP, He A, Truong A, Patel S, Nelson SF, Horvath S, Berliner JA, Kirchgessner TG, Lusis AJ. Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids. Proceedings of the National Academy of Sciences of the United States of America. 103: 12741-6. PMID 16912112 DOI: 10.1073/Pnas.0605457103  1
2004 Castellani LW, Gargalovic P, Febbraio M, Charugundla S, Jien ML, Lusis AJ. Mechanisms mediating insulin resistance in transgenic mice overexpressing mouse apolipoprotein A-II. Journal of Lipid Research. 45: 2377-87. PMID 15466364 DOI: 10.1194/Jlr.M400345-Jlr200  1
2004 Yeh M, Cole AL, Choi J, Liu Y, Tulchinsky D, Qiao JH, Fishbein MC, Dooley AN, Hovnanian T, Mouilleseaux K, Vora DK, Yang WP, Gargalovic P, Kirchgessner T, Shyy JY, et al. Role for sterol regulatory element-binding protein in activation of endothelial cells by phospholipid oxidation products. Circulation Research. 95: 780-8. PMID 15388640 DOI: 10.1161/01.Res.0000146030.53089.18  1
2004 Wang X, Gargalovic P, Wong J, Gu JL, Wu X, Qi H, Wen P, Xi L, Tan B, Gogliotti R, Castellani LW, Chatterjee A, Lusis AJ. Hyplip2, a new gene for combined hyperlipidemia and increased atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 24: 1928-34. PMID 15331434 DOI: 10.1161/01.Atv.0000143385.30354.Bb  1
2003 Gargalovic P, Dory L. Cellular apoptosis is associated with increased caveolin-1 expression in macrophages. Journal of Lipid Research. 44: 1622-32. PMID 12777465 DOI: 10.1194/Jlr.M300140-Jlr200  1
2003 Gargalovic P, Dory L. Caveolins and macrophage lipid metabolism. Journal of Lipid Research. 44: 11-21. PMID 12518018 DOI: 10.1194/Jlr.R200005-Jlr200  1
2001 Gargalovic P, Dory L. Caveolin-1 and caveolin-2 expression in mouse macrophages. High density lipoprotein 3-stimulated secretion and a lack of significant subcellular co-localization. The Journal of Biological Chemistry. 276: 26164-70. PMID 11316799 DOI: 10.1074/Jbc.M011291200  1
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