| Year |
Citation |
Score |
| 2023 |
Liu X, Nie L, Zhang Y, Yan Y, Wang C, Colic M, Olszewski K, Horbath A, Chen X, Lei G, Mao C, Wu S, Zhuang L, Poyurovsky MV, James You M, ... ... Billadeau DD, et al. Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis. Nature Cell Biology. PMID 36747082 DOI: 10.1038/s41556-023-01091-2 |
0.305 |
|
| 2022 |
Yang S, Tang Y, Liu Y, Brown AJ, Schaks M, Ding B, Kramer DA, Mietkowska M, Ding L, Alekhina O, Billadeau DD, Chowdhury S, Wang J, Rottner K, Chen B. Arf GTPase activates the WAVE regulatory complex through a distinct binding site. Science Advances. 8: eadd1412. PMID 36516255 DOI: 10.1126/sciadv.add1412 |
0.309 |
|
| 2022 |
Messex JK, Adams KLA, Hawkins WG, DeNardo D, Bardeesy N, Billadeau DD, Liou GY. Oncogenic Kras-Mediated Cytokine CCL15 Regulates Pancreatic Cancer Cell Migration and Invasion through ROS. Cancers. 14. PMID 35565279 DOI: 10.3390/cancers14092153 |
0.314 |
|
| 2022 |
Ham H, Medlyn M, Billadeau DD. Locked and Loaded: Mechanisms Regulating Natural Killer Cell Lytic Granule Biogenesis and Release. Frontiers in Immunology. 13: 871106. PMID 35558071 DOI: 10.3389/fimmu.2022.871106 |
0.325 |
|
| 2022 |
Giridharan SSP, Luo G, Rivero-Rios P, Steinfeld N, Tronchere H, Singla A, Burstein E, Billadeau DD, Sutton MA, Weisman LS. Lipid kinases VPS34 and PIKfyve coordinate a phosphoinositide cascade to regulate Retriever-mediated recycling on endosomes. Elife. 11. PMID 35040777 DOI: 10.7554/eLife.69709 |
0.365 |
|
| 2021 |
Wen T, Barham W, Li Y, Zhang H, Gicobi JK, Hirdler JB, Liu X, Ham H, Peterson Martinez KE, Lucien F, Lavoie RR, Li H, Correia C, Monie DD, An Z, ... ... Billadeau DD, et al. NKG7 is a T-cell intrinsic therapeutic target for improving antitumor cytotoxicity and cancer immunotherapy. Cancer Immunology Research. PMID 34911739 DOI: 10.1158/2326-6066.CIR-21-0539 |
0.306 |
|
| 2021 |
Capitani N, Onnis A, Finetti F, Cassioli C, Plebani A, Brunetti J, Troilo A, D'Elios S, Baronio M, Gazzurelli L, Della Bella C, Billadeau DD, D'Elios MM, Lougaris V, Baldari CT. A CVID-associated variant in the ciliogenesis protein CCDC28B disrupts immune synapse assembly. Cell Death and Differentiation. PMID 34294890 DOI: 10.1038/s41418-021-00837-5 |
0.313 |
|
| 2020 |
Chen H, Victor AK, Klein J, Tacer KF, Tai DJ, de Esch C, Nuttle A, Temirov J, Burnett LC, Rosenbaum M, Zhang Y, Ding L, Moresco JJ, Diedrich JK, Yates JR, ... ... Billadeau DD, et al. Loss of MAGEL2 in Prader-Willi syndrome leads to decreased secretory granule and neuropeptide production. Jci Insight. 5. PMID 32879135 DOI: 10.1172/Jci.Insight.138576 |
0.316 |
|
| 2020 |
Phatarpekar PV, Overlee BL, Leehan A, Wilton KM, Ham H, Billadeau DD. The septin cytoskeleton regulates natural killer cell lytic granule release. The Journal of Cell Biology. 219. PMID 32841357 DOI: 10.1083/Jcb.202002145 |
0.433 |
|
| 2020 |
Walpole GFW, Plumb JD, Chung D, Tang B, Boulay B, Osborne DG, Piotrowski JT, Catz SD, Billadeau DD, Grinstein S, Jaumouillé V. Inactivation of Rho GTPases by Burkholderia cenocepacia Induces a WASH-Mediated Actin Polymerization that Delays Phagosome Maturation. Cell Reports. 31: 107721. PMID 32492429 DOI: 10.1016/J.Celrep.2020.107721 |
0.708 |
|
| 2020 |
Quan MY, Guo Q, Liu J, Yang R, Bai J, Wang W, Cai Y, Han R, Lv YQ, Ding L, Billadeau DD, Lou Z, Bellusci S, Li X, Zhang JS. An FGFR/AKT/SOX2 Signaling Axis Controls Pancreatic Cancer Stemness. Frontiers in Cell and Developmental Biology. 8: 287. PMID 32457900 DOI: 10.3389/Fcell.2020.00287 |
0.353 |
|
| 2020 |
Liu D, Yang F, Liu Z, Wang J, Huang W, Meng W, Billadeau DD, Sun Q, Mo X, Jia D. Structure of TBC1D23 N-terminus reveals a novel role for rhodanese domain. Plos Biology. 18: e3000746. PMID 32453802 DOI: 10.1371/Journal.Pbio.3000746 |
0.347 |
|
| 2020 |
Guo Q, Quan M, Dong J, Bai J, Wang J, Han R, Wang W, Cai Y, Lv YQ, Chen Q, Xu H, Lyu HD, Deng L, Zhou D, Xiao X, ... ... Billadeau DD, et al. The WW domains dictate isoform-specific regulation of YAP1 stability and pancreatic cancer cell malignancy. Theranostics. 10: 4422-4436. PMID 32292505 DOI: 10.7150/Thno.42795 |
0.393 |
|
| 2020 |
Tu Y, Zhao L, Billadeau DD, Jia D. Endosome-to-TGN Trafficking: Organelle-Vesicle and Organelle-Organelle Interactions. Frontiers in Cell and Developmental Biology. 8: 163. PMID 32258039 DOI: 10.3389/Fcell.2020.00163 |
0.341 |
|
| 2020 |
Ding L, Billadeau DD. Glycogen synthase kinase-3β: a novel therapeutic target for pancreatic cancer. Expert Opinion On Therapeutic Targets. 1-10. PMID 32178549 DOI: 10.1080/14728222.2020.1743681 |
0.361 |
|
| 2020 |
Yong X, Zhao L, Deng W, Sun H, Zhou X, Mao L, Hu W, Shen X, Sun Q, Billadeau DD, Xue Y, Jia D. Mechanism of cargo recognition by retromer-linked SNX-BAR proteins. Plos Biology. 18: e3000631. PMID 32150533 DOI: 10.1371/Journal.Pbio.3000631 |
0.375 |
|
| 2020 |
Phatarpekar PV, Billadeau DD. Molecular regulation of the plasma membrane-proximal cellular steps involved in NK cell cytolytic function. Journal of Cell Science. 133. PMID 32086255 DOI: 10.1242/Jcs.240424 |
0.425 |
|
| 2020 |
Ding L, Han L, Dube J, Billadeau DD. Erratum. WASH regulates glucose homeostasis by facilitating GLUT2 receptor recycling in pancreatic B-cells. (Diabetes(2019)68(377–386)Doi: 10.2337/db18-0189) Diabetes. 69. DOI: 10.2337/Db20Er05A |
0.328 |
|
| 2020 |
Ding L, Roeck KR, Alekhina O, Schmitt DM, Billadeau DD. Abstract 4138: Glycogen synthase kinase-3 inhibition impairs DNA damage response through ubiquitin ligase hHYD-mediated TopBP1 degradation Cancer Research. 80: 4138-4138. DOI: 10.1158/1538-7445.Am2020-4138 |
0.362 |
|
| 2019 |
Starokadomskyy P, Wilton KM, Krzewski K, Lopez A, Sifuentes-Dominguez L, Overlee B, Chen Q, Ray A, Gil-Krzewska A, Peterson M, Kinch LN, Rohena L, Grunebaum E, Zinn AR, Grishin NV, ... Billadeau DD, et al. NK cell defects in X-linked pigmentary reticulate disorder. Jci Insight. 4. PMID 31672938 DOI: 10.1172/Jci.Insight.125688 |
0.367 |
|
| 2019 |
Huang W, Liu Z, Yang F, Zhou H, Yong X, Yang X, Zhou Y, Xue L, Zhang Y, Liu D, Meng W, Zhang W, Zhang X, Shen X, Sun Q, ... ... Billadeau DD, et al. Structural and functional studies of TBC1D23 C-terminal domain provide a link between endosomal trafficking and PCH. Proceedings of the National Academy of Sciences of the United States of America. PMID 31624125 DOI: 10.1073/Pnas.1909316116 |
0.304 |
|
| 2019 |
Singla A, Fedoseienko A, Giridharan SSP, Overlee BL, Lopez A, Jia D, Song J, Huff-Hardy K, Weisman L, Burstein E, Billadeau DD. Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling. Nature Communications. 10: 4271. PMID 31537807 DOI: 10.1038/S41467-019-12221-6 |
0.381 |
|
| 2019 |
Ding L, Madamsetty VS, Kiers S, Alekhina O, Ugolkov A, Dube J, Zhang Y, Zhang JS, Wang E, Dutta SK, Schmitt DM, Giles FJ, Kozikowski AP, Mazar AP, Mukhopadhyay D, ... Billadeau DD, et al. Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to Chemotherapy by Abrogating the TopBP1/ATR-Mediated DNA Damage Response. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31533931 DOI: 10.1158/1078-0432.Ccr-19-0799 |
0.361 |
|
| 2019 |
Generous AR, Harrison OJ, Troyanovsky RB, Mateo M, Navaratnarajah CK, Donohue RC, Pfaller CK, Alekhina O, Sergeeva AP, Indra I, Thornburg T, Kochetkova I, Billadeau DD, Taylor MP, Troyanovsky SM, et al. Trans-endocytosis elicited by nectins transfers cytoplasmic cargo including infectious material between cells. Journal of Cell Science. PMID 31331966 DOI: 10.1242/Jcs.235507 |
0.382 |
|
| 2019 |
Wilton KM, Overlee BL, Billadeau DD. NKG2D/DAP10 Signaling recruits EVL to the cytotoxic synapse to generate F-actin and promote NK cell cytotoxicity. Journal of Cell Science. PMID 31235500 DOI: 10.1242/Jcs.230508 |
0.457 |
|
| 2019 |
Wu X, Stenson M, Abeykoon J, Nowakowski KE, Zhang L, Lawson J, Wellik L, Li Y, Krull J, Wenzl K, Novak AJ, Ansell S, Bishop G, Billadeau DD, Peng KW, et al. Targeting glycogen synthase kinase 3 for therapeutic benefit in lymphoma. Blood. PMID 31101621 DOI: 10.1182/Blood.2018874560 |
0.419 |
|
| 2019 |
Tsarouhas V, Liu D, Tsikala G, Fedoseienko A, Zinn K, Matsuda R, Billadeau DD, Samakovlis C. WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis. Nature Communications. 10: 2193. PMID 31097705 DOI: 10.1038/S41467-019-10229-6 |
0.363 |
|
| 2018 |
Ding L, Han L, Dube J, Billadeau DD. WASH Regulates Glucose Homeostasis by Facilitating Glut2 Receptor Recycling in Pancreatic Beta Cells. Diabetes. PMID 30425062 DOI: 10.2337/Db18-0189 |
0.358 |
|
| 2018 |
Wilton KM, Billadeau DD. VASP Regulates NK Cell Lytic Granule Convergence. Journal of Immunology (Baltimore, Md. : 1950). PMID 30282752 DOI: 10.4049/Jimmunol.1800254 |
0.43 |
|
| 2018 |
Miyata N, Morris LL, Chen Q, Thorne C, Singla A, Zhu W, Winter M, Melton SD, Li H, Sifuentes-Dominguez L, Llano E, Huff-Hardy K, Starokadomskyy P, Lopez A, Reese TA, ... ... Billadeau DD, et al. Microbial Sensing by Intestinal Myeloid Cells Controls Carcinogenesis and Epithelial Differentiation. Cell Reports. 24: 2342-2355. PMID 30157428 DOI: 10.1016/J.Celrep.2018.07.066 |
0.383 |
|
| 2018 |
Wang J, Fedoseienko A, Chen B, Burstein E, Jia D, Billadeau DD. Endosomal Receptor Trafficking: Retromer and Beyond. Traffic (Copenhagen, Denmark). PMID 29667289 DOI: 10.1111/Tra.12574 |
0.39 |
|
| 2018 |
Fedoseienko A, Wijers M, Wolters JC, Dekker D, Smit M, Huijkman N, Kloosterhuis N, Klug H, Schepers A, Willems van Dijk K, Levels JH, Billadeau DD, Hofker MH, van Deursen J, Westerterp M, et al. COMMD Family Regulates Plasma LDL Levels and Attenuates Atherosclerosis Through Stabilizing the CCC Complex in Endosomal LDLR Trafficking. Circulation Research. PMID 29545368 DOI: 10.1161/Circresaha.117.312004 |
0.312 |
|
| 2018 |
Ding L, Zhang J, Dube JR, Madamsetty VS, Schmitt DM, Mukhopadhyay D, Billadeau DD. Abstract 2926: The glycogen synthase kinase-3 inhibitor, 9-ING-41, synergizes with chemotherapy to inhibit pancreatic tumor growth in vivo Cancer Research. 78: 2926-2926. DOI: 10.1158/1538-7445.Am2018-2926 |
0.378 |
|
| 2017 |
Almassalha LM, Bauer GM, Wu W, Cherkezyan L, Zhang D, Kendra A, Gladstein S, Chandler JE, VanDerway D, Seagle BL, Ugolkov A, Billadeau DD, O'Halloran TV, Mazar AP, Roy HK, et al. Macrogenomic engineering via modulation of the scaling of chromatin packing density. Nature Biomedical Engineering. 1: 902-913. PMID 29450107 DOI: 10.1038/S41551-017-0153-2 |
0.325 |
|
| 2017 |
McNally KE, Faulkner R, Steinberg F, Gallon M, Ghai R, Pim D, Langton P, Pearson N, Danson CM, Nägele H, Morris LL, Singla A, Overlee BL, Heesom KJ, Sessions R, ... ... Billadeau DD, et al. Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling. Nature Cell Biology. PMID 28892079 DOI: 10.1038/Ncb3610 |
0.389 |
|
| 2017 |
Jin X, Pan Y, Wang L, Ma T, Zhang L, Tang AH, Billadeau DD, Wu H, Huang H. Fructose-1,6-bisphosphatase inhibits ERK activation and bypasses gemcitabine resistance in pancreatic cancer by blocking IQGAP1-MAPK interaction. Cancer Research. PMID 28720574 DOI: 10.1158/0008-5472.Can-16-3143 |
0.421 |
|
| 2017 |
Alekhina O, Burstein E, Billadeau DD. Cellular functions of WASP family proteins at a glance. Journal of Cell Science. PMID 28646090 DOI: 10.1242/Jcs.199570 |
0.396 |
|
| 2017 |
Ding L, Liou GY, Schmitt DM, Storz P, Zhang JS, Billadeau DD. Glycogen synthase kinase-3β ablation limits pancreatitis induced acinar-to-ductal metaplasia. The Journal of Pathology. PMID 28639695 DOI: 10.1002/Path.4928 |
0.32 |
|
| 2017 |
Walz A, Ugolkov A, Chandra S, Kozikowski A, Carneiro BA, O'Halloran TV, Giles FJ, Billadeau DD, Mazar AP. Molecular Pathways: Revisiting Glycogen Synthase Kinase-3β as a target for the treatment of cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28053024 DOI: 10.1158/1078-0432.Ccr-15-2240 |
0.336 |
|
| 2017 |
Mathison A, Salmonson A, Paradise B, Missfeldt M, Iovanna J, Billadeau D, Urrutia R, Lomberk G. Abstract 1391: The epigenetic regulator, G9a, is a KRAS-inducible protein and its inactivation inhibits PanIN formation by this oncogene Cancer Research. 77: 1391-1391. DOI: 10.1158/1538-7445.Am2017-1391 |
0.384 |
|
| 2016 |
Jia D, Zhang JS, Li F, Wang J, Deng Z, White MA, Osborne DG, Phillips-Krawczak C, Gomez TS, Li H, Singla A, Burstein E, Billadeau DD, Rosen MK. Structural and mechanistic insights into regulation of the retromer coat by TBC1d5. Nature Communications. 7: 13305. PMID 27827364 DOI: 10.1038/Ncomms13305 |
0.371 |
|
| 2016 |
Boddicker RL, Razidlo GL, Dasari S, Zeng Y, Hu G, Knudson RA, Greipp PT, Davila JI, Johnson SH, Porcher JC, Smadbeck JB, Eckloff BW, Billadeau DD, Kurtin PJ, McNiven MA, et al. Integrated mate-pair and RNA sequencing identifies novel, targetable gene fusions in peripheral T-cell lymphoma. Blood. PMID 27297792 DOI: 10.1182/Blood-2016-03-707141 |
0.385 |
|
| 2016 |
Baumgart S, Chen NM, Zhang JS, Billadeau DD, Gaisina I, Kozikowski AP, Singh S, Fink D, Strobel P, Klindt C, Zhang L, Bamlet WR, Koenig A, Hessmann E, Gress T, et al. GSK-3β governs inflammation-induced NFATc2 signaling hubs to promote pancreatic cancer progression. Molecular Cancer Therapeutics. PMID 26823495 DOI: 10.1158/1535-7163.Mct-15-0309 |
0.395 |
|
| 2016 |
Evans DL, Zhang H, Ham H, Pei H, Lee S, Kim J, Billadeau DD, Lou Z. MMSET is dynamically regulated during cell-cycle progression and promotes normal DNA replication. Cell Cycle (Georgetown, Tex.). 15: 95-105. PMID 26771714 DOI: 10.1080/15384101.2015.1121323 |
0.673 |
|
| 2016 |
Hessmann E, Zhang JS, Chen NM, Hasselluhn M, Liou GY, Storz P, Ellenrieder V, Billadeau DD, Koenig A. NFATc4 Regulates Sox9 Gene Expression in Acinar Cell Plasticity and Pancreatic Cancer Initiation. Stem Cells International. 2016: 5272498. PMID 26697077 DOI: 10.1155/2016/5272498 |
0.382 |
|
| 2015 |
Chini CC, Espindola-Netto JM, Mondal G, Gonzalez Guerrico A, Nin V, Escande C, Sola-Penna M, Zhang JS, Billadeau DD, Chini EN. SIRT1 activating compounds (STACs) negatively regulate pancreatic cancer cell growth and viability through a SIRT1-lysosomal-dependent pathway. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26655844 DOI: 10.1158/1078-0432.Ccr-15-1760 |
0.32 |
|
| 2015 |
Gaisina IN, Tueckmantel W, Ugolkov A, Shen S, Hoffen J, Dubrovskyi O, Mazar A, Schoon RA, Billadeau D, Kozikowski AP. Identification of HDAC6-Selective Inhibitors of Low Cancer Cell Cytotoxicity. Chemmedchem. PMID 26592932 DOI: 10.1002/Cmdc.201500456 |
0.348 |
|
| 2015 |
Li H, Koo Y, Mao X, Sifuentes-Dominguez L, Morris LL, Jia D, Miyata N, Faulkner RA, van Deursen JM, Vooijs M, Billadeau DD, van de Sluis B, Cleaver O, Burstein E. Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling. The Journal of Cell Biology. 211: 605-17. PMID 26553930 DOI: 10.1083/Jcb.201505108 |
0.424 |
|
| 2015 |
Lee SB, Kim JJ, Nam HJ, Gao B, Yin P, Qin B, Yi SY, Ham H, Evans D, Kim SH, Zhang J, Deng M, Liu T, Zhang H, Billadeau DD, et al. Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1. Molecular Cell. PMID 26387737 DOI: 10.1016/J.Molcel.2015.08.011 |
0.666 |
|
| 2015 |
Osborne DG, Phillips-Krawczak CA, Billadeau DD. Monitoring receptor trafficking following retromer and WASH deregulation. Methods in Cell Biology. 130: 199-213. PMID 26360036 DOI: 10.1016/Bs.Mcb.2015.03.018 |
0.416 |
|
| 2015 |
Bamidele AO, Kremer KN, Hirsova P, Clift IC, Gores GJ, Billadeau DD, Hedin KE. IQGAP1 promotes CXCR4 chemokine receptor function and trafficking via EEA-1+ endosomes. The Journal of Cell Biology. 210: 257-72. PMID 26195666 DOI: 10.1083/Jcb.201411045 |
0.511 |
|
| 2015 |
Osborne DG, Piotrowski JT, Dick CJ, Zhang JS, Billadeau DD. SNX17 affects T cell activation by regulating TCR and integrin recycling. Journal of Immunology (Baltimore, Md. : 1950). 194: 4555-66. PMID 25825439 DOI: 10.4049/Jimmunol.1402734 |
0.756 |
|
| 2015 |
Ham H, Huynh W, Schoon RA, Vale RD, Billadeau DD. HkRP3 is a microtubule-binding protein regulating lytic granule clustering and NK cell killing. Journal of Immunology (Baltimore, Md. : 1950). 194: 3984-96. PMID 25762780 DOI: 10.4049/Jimmunol.1402897 |
0.42 |
|
| 2015 |
Chen NM, Singh G, Koenig A, Liou GY, Storz P, Zhang JS, Regul L, Nagarajan S, Kühnemuth B, Johnsen SA, Hebrok M, Siveke J, Billadeau DD, Ellenrieder V, Hessmann E. NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas. Gastroenterology. 148: 1024-1034.e9. PMID 25623042 DOI: 10.1053/J.Gastro.2015.01.033 |
0.341 |
|
| 2015 |
Singh SK, Chen NM, Hessmann E, Siveke J, Lahmann M, Singh G, Voelker N, Vogt S, Esposito I, Schmidt A, Brendel C, Stiewe T, Gaedcke J, Mernberger M, Crawford HC, ... ... Billadeau DD, et al. Antithetical NFATc1-Sox2 and p53-miR200 signaling networks govern pancreatic cancer cell plasticity. The Embo Journal. 34: 517-30. PMID 25586376 DOI: 10.15252/Embj.201489574 |
0.405 |
|
| 2015 |
Deng ZH, Gomez TS, Osborne DG, Phillips-Krawczak CA, Zhang JS, Billadeau DD. Nuclear FAM21 participates in NF-κB-dependent gene regulation in pancreatic cancer cells. Journal of Cell Science. 128: 373-84. PMID 25431135 DOI: 10.1242/Jcs.161513 |
0.391 |
|
| 2015 |
Phillips-Krawczak CA, Singla A, Starokadomskyy P, Deng Z, Osborne DG, Li H, Dick CJ, Gomez TS, Koenecke M, Zhang JS, Dai H, Sifuentes-Dominguez LF, Geng LN, Kaufmann SH, Hein MY, ... ... Billadeau DD, et al. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. Molecular Biology of the Cell. 26: 91-103. PMID 25355947 DOI: 10.1091/Mbc.E14-06-1073 |
0.316 |
|
| 2014 |
McGough IJ, Steinberg F, Jia D, Barbuti PA, McMillan KJ, Heesom KJ, Whone AL, Caldwell MA, Billadeau DD, Rosen MK, Cullen PJ. Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation. Current Biology : Cb. 24: 1670-6. PMID 24980502 DOI: 10.1016/J.Cub.2014.06.024 |
0.326 |
|
| 2014 |
Meng XW, Koh BD, Zhang JS, Flatten KS, Schneider PA, Billadeau DD, Hess AD, Smith BD, Karp JE, Kaufmann SH. Poly(ADP-ribose) polymerase inhibitors sensitize cancer cells to death receptor-mediated apoptosis by enhancing death receptor expression. The Journal of Biological Chemistry. 289: 20543-58. PMID 24895135 DOI: 10.1074/Jbc.M114.549220 |
0.384 |
|
| 2014 |
Graham DB, Osborne DG, Piotrowski JT, Gomez TS, Gmyrek GB, Akilesh HM, Dani A, Billadeau DD, Swat W. Dendritic cells utilize the evolutionarily conserved WASH and retromer complexes to promote MHCII recycling and helper T cell priming. Plos One. 9: e98606. PMID 24886983 DOI: 10.1371/Journal.Pone.0098606 |
0.751 |
|
| 2014 |
Baumgart S, Chen NM, Siveke JT, König A, Zhang JS, Singh SK, Wolf E, Bartkuhn M, Esposito I, Heßmann E, Reinecke J, Nikorowitsch J, Brunner M, Singh G, Fernandez-Zapico ME, ... ... Billadeau DD, et al. Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D. Cancer Discovery. 4: 688-701. PMID 24694735 DOI: 10.1158/2159-8290.Cd-13-0593 |
0.37 |
|
| 2014 |
Zhang JS, Herreros-Villanueva M, Herreros-Vilanueva M, Koenig A, Deng Z, de Narvajas AA, Gomez TS, Meng X, Bujanda L, Ellenrieder V, Li XK, Kaufmann SH, Billadeau DD. Differential activity of GSK-3 isoforms regulates NF-κB and TRAIL- or TNFα induced apoptosis in pancreatic cancer cells. Cell Death & Disease. 5: e1142. PMID 24675460 DOI: 10.1038/Cddis.2014.102 |
0.35 |
|
| 2014 |
Herreros-Villanueva M, Bujanda L, Billadeau DD, Zhang JS. Embryonic stem cell factors and pancreatic cancer. World Journal of Gastroenterology. 20: 2247-54. PMID 24605024 DOI: 10.3748/Wjg.V20.I9.2247 |
0.367 |
|
| 2014 |
Ham H, Billadeau DD. Human immunodeficiency syndromes affecting human natural killer cell cytolytic activity. Frontiers in Immunology. 5: 2. PMID 24478771 DOI: 10.3389/Fimmu.2014.00002 |
0.479 |
|
| 2014 |
Kim J, Shapiro MJ, Bamidele AO, Gurel P, Thapa P, Higgs HN, Hedin KE, Shapiro VS, Billadeau DD. Coactosin-like 1 antagonizes cofilin to promote lamellipodial protrusion at the immune synapse. Plos One. 9: e85090. PMID 24454796 DOI: 10.1371/Journal.Pone.0085090 |
0.692 |
|
| 2014 |
Razidlo GL, Schroeder B, Chen J, Billadeau DD, McNiven MA. Vav1 as a central regulator of invadopodia assembly. Current Biology : Cb. 24: 86-93. PMID 24332539 DOI: 10.1016/J.Cub.2013.11.013 |
0.431 |
|
| 2014 |
Pal K, Cao Y, Gaisina IN, Bhattacharya S, Dutta SK, Wang E, Gunosewoyo H, Kozikowski AP, Billadeau DD, Mukhopadhyay D. Inhibition of GSK-3 induces differentiation and impaired glucose metabolism in renal cancer. Molecular Cancer Therapeutics. 13: 285-96. PMID 24327518 DOI: 10.1158/1535-7163.Mct-13-0681 |
0.371 |
|
| 2014 |
D'Assoro AB, Liu T, Quatraro C, Amato A, Opyrchal M, Leontovich A, Ikeda Y, Ohmine S, Lingle W, Suman V, Ecsedy J, Iankov I, Di Leonardo A, Ayers-Inglers J, Degnim A, ... Billadeau D, et al. The mitotic kinase Aurora--a promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα(+) breast cancer cells. Oncogene. 33: 599-610. PMID 23334326 DOI: 10.1038/Onc.2012.628 |
0.391 |
|
| 2014 |
Zhang JS, Herreros-Villanueva M, Koenig A, Deng Z, Narvajas AAMD, Gomez TS, Meng X, Bujanda L, Ellenrieder V, Li XK, Kaufmann SH, Billadeau DD. Erratum: Differential activity of GSK-3 isoforms regulates NF-κB and TRAIL- or TNFα induced apoptosis in pancreatic cancer cells (Cell Death and Disease (2014) 5 (e1142) DOI: 10.1038/cddis.2014.102) Cell Death and Disease. 5. DOI: 10.1038/Cddis.2014.341 |
0.374 |
|
| 2013 |
De Narvajas AAM, Gomez TS, Zhang JS, Mann AO, Taoda Y, Gorman JA, Herreros-Villanueva M, Gress TM, Ellenrieder V, Bujand L, Kim DH, Kozikowski AP, Koenig A, Billadeau DD. Epigenetic regulation of autophagy by the methyltransferase G9a Molecular and Cellular Biology. 33: 3983-3993. PMID 23918802 DOI: 10.1128/Mcb.00813-13 |
0.686 |
|
| 2013 |
Seaman MN, Gautreau A, Billadeau DD. Retromer-mediated endosomal protein sorting: all WASHed up! Trends in Cell Biology. 23: 522-8. PMID 23721880 DOI: 10.1016/J.Tcb.2013.04.010 |
0.374 |
|
| 2013 |
Razidlo GL, Wang Y, Chen J, Krueger EW, Billadeau DD, McNiven MA. Dynamin 2 potentiates invasive migration of pancreatic tumor cells through stabilization of the Rac1 GEF Vav1. Developmental Cell. 24: 573-85. PMID 23537630 DOI: 10.1016/J.Devcel.2013.02.010 |
0.389 |
|
| 2013 |
Ham H, Guerrier S, Kim J, Schoon RA, Anderson EL, Hamann MJ, Lou Z, Billadeau DD. Dedicator of cytokinesis 8 interacts with talin and Wiskott-Aldrich syndrome protein to regulate NK cell cytotoxicity. Journal of Immunology (Baltimore, Md. : 1950). 190: 3661-9. PMID 23455509 DOI: 10.4049/Jimmunol.1202792 |
0.713 |
|
| 2013 |
Liu C, Billadeau DD, Abdelhakim H, Leof E, Kaibuchi K, Bernabeu C, Bloom GS, Yang L, Boardman L, Shah VH, Kang N. IQGAP1 suppresses TβRII-mediated myofibroblastic activation and metastatic growth in liver. The Journal of Clinical Investigation. 123: 1138-56. PMID 23454766 DOI: 10.1172/Jci63836 |
0.367 |
|
| 2013 |
Hao YH, Doyle JM, Ramanathan S, Gomez TS, Jia D, Xu M, Chen ZJ, Billadeau DD, Rosen MK, Potts PR. Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination. Cell. 152: 1051-64. PMID 23452853 DOI: 10.1016/J.Cell.2013.01.051 |
0.344 |
|
| 2013 |
Leontovich AA, Salisbury JL, Veroux M, Tallarita T, Billadeau D, McCubrey J, Ingle J, Galanis E, D'Assoro AB. Inhibition of Cdk2 activity decreases Aurora-A kinase centrosomal localization and prevents centrosome amplification in breast cancer cells Oncology Reports. 29: 1785-1788. PMID 23446853 DOI: 10.3892/Or.2013.2313 |
0.391 |
|
| 2013 |
Piotrowski JT, Gomez TS, Schoon RA, Mangalam AK, Billadeau DD. WASH knockout T cells demonstrate defective receptor trafficking, proliferation, and effector function. Molecular and Cellular Biology. 33: 958-73. PMID 23275443 DOI: 10.1128/Mcb.01288-12 |
0.755 |
|
| 2013 |
Baumgart S, Chen N, Brunner M, Johanna R, Nikorowitsch J, Singh S, König A, Zhang J, Wolf E, Bartkuhn M, Siveke J, Esposito I, Glesel E, Geisel B, Reutlinger K, ... ... Billadeau D, et al. Nuclear factor of activated T-cells c1 integrates STAT3 signals to link chronic inflammation and carcinogenesis in the pancreas Pancreatology. 13: S16. DOI: 10.1016/J.Pan.2013.04.047 |
0.435 |
|
| 2012 |
Gomez TS, Gorman JA, de Narvajas AA, Koenig AO, Billadeau DD. Trafficking defects in WASH-knockout fibroblasts originate from collapsed endosomal and lysosomal networks. Molecular Biology of the Cell. 23: 3215-28. PMID 22718907 DOI: 10.1091/Mbc.E12-02-0101 |
0.702 |
|
| 2012 |
Liu TT, Gomez TS, Sackey BK, Billadeau DD, Burd CG. Rab GTPase regulation of retromer-mediated cargo export during endosome maturation. Molecular Biology of the Cell. 23: 2505-15. PMID 22593205 DOI: 10.1091/Mbc.E11-11-0915 |
0.379 |
|
| 2012 |
Gorman JA, Babich A, Dick CJ, Schoon RA, Koenig A, Gomez TS, Burkhardt JK, Billadeau DD. The cytoskeletal adaptor protein IQGAP1 regulates TCR-mediated signaling and filamentous actin dynamics. Journal of Immunology (Baltimore, Md. : 1950). 188: 6135-44. PMID 22573807 DOI: 10.4049/Jimmunol.1103487 |
0.733 |
|
| 2012 |
Jia D, Gomez TS, Billadeau DD, Rosen MK. Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer. Molecular Biology of the Cell. 23: 2352-61. PMID 22513087 DOI: 10.1091/Mbc.E11-12-1059 |
0.408 |
|
| 2012 |
Daftary GS, Lomberk GA, Buttar NS, Allen TW, Grzenda A, Zhang J, Zheng Y, Mathison AJ, Gada RP, Calvo E, Iovanna JL, Billadeau DD, Prendergast FG, Urrutia R. Detailed structural-functional analysis of the Krüppel-like factor 16 (KLF16) transcription factor reveals novel mechanisms for silencing Sp/KLF sites involved in metabolism and endocrinology. The Journal of Biological Chemistry. 287: 7010-25. PMID 22203677 DOI: 10.1074/Jbc.M111.266007 |
0.404 |
|
| 2012 |
Baumgart S, Glesel E, Singh G, Chen NM, Reutlinger K, Zhang J, Billadeau DD, Fernandez-Zapico ME, Gress TM, Singh SK, Ellenrieder V. Restricted heterochromatin formation links NFATc2 repressor activity with growth promotion in pancreatic cancer. Gastroenterology. 142: 388-98.e1-7. PMID 22079596 DOI: 10.1053/J.Gastro.2011.11.001 |
0.395 |
|
| 2012 |
Razidlo GL, Wang Y, Chen J, Billadeau DD, McNiven MA. 406 Invasive Migration of Pancreatic Tumor Cells is Potentiated by a Novel Stabilization of the Oncogenic RAC GEF Vav1 by the Large GTPase Dynamin 2 Gastroenterology. 142: S-90. DOI: 10.1016/S0016-5085(12)60342-4 |
0.333 |
|
| 2012 |
Baumgart S, Chen N, Reinecke J, Klindt C, Nikorowitsch J, Singh S, Zhang J, Wolf E, Bartkuhn M, Griesmann H, Siveke J, Esposito I, Geisel B, Reutlinger K, Singh G, ... ... Billadeau D, et al. Nuclear NFATc1 integrates STAT3 signaling to promote Kras-driven pancreatic carcinogenesis Pancreatology. 12: 548-549. DOI: 10.1016/J.Pan.2012.11.161 |
0.315 |
|
| 2011 |
Colón-Franco JM, Gomez TS, Billadeau DD. Dynamic remodeling of the actin cytoskeleton by FMNL1γ is required for structural maintenance of the Golgi complex. Journal of Cell Science. 124: 3118-26. PMID 21868368 DOI: 10.1242/Jcs.083725 |
0.367 |
|
| 2011 |
Meng XW, Peterson KL, Dai H, Schneider P, Lee SH, Zhang JS, Koenig A, Bronk S, Billadeau DD, Gores GJ, Kaufmann SH. High cell surface death receptor expression determines type I versus type II signaling. The Journal of Biological Chemistry. 286: 35823-33. PMID 21865165 DOI: 10.1074/Jbc.M111.240432 |
0.376 |
|
| 2011 |
Zhang JS, Koenig A, Young C, Billadeau DD. GRB2 couples RhoU to epidermal growth factor receptor signaling and cell migration. Molecular Biology of the Cell. 22: 2119-30. PMID 21508312 DOI: 10.1091/Mbc.E10-12-0969 |
0.408 |
|
| 2011 |
Routray C, Liu C, Yaqoob U, Billadeau DD, Bloch KD, Kaibuchi K, Shah VH, Kang N. Protein kinase G signaling disrupts Rac1-dependent focal adhesion assembly in liver specific pericytes. American Journal of Physiology. Cell Physiology. 301: C66-74. PMID 21451103 DOI: 10.1152/Ajpcell.00038.2011 |
0.443 |
|
| 2011 |
Zhang JS, Koenig A, Harrison A, Ugolkov AV, Fernandez-Zapico ME, Couch FJ, Billadeau DD. Mutant K-Ras increases GSK-3Β gene expression via an ETS-p300 transcriptional complex in pancreatic cancer Oncogene. 30: 3705-3715. PMID 21441955 DOI: 10.1038/Onc.2011.90 |
0.346 |
|
| 2011 |
Bida AT, Upshaw Neff JL, Dick CJ, Schoon RA, Brickshawana A, Chini CC, Billadeau DD. 2B4 utilizes ITAM-containing receptor complexes to initiate intracellular signaling and cytolysis. Molecular Immunology. 48: 1149-59. PMID 21439641 DOI: 10.1016/J.Molimm.2011.02.008 |
0.75 |
|
| 2011 |
Dehring DA, Clarke F, Ricart BG, Huang Y, Gomez TS, Williamson EK, Hammer DA, Billadeau DD, Argon Y, Burkhardt JK. Hematopoietic lineage cell-specific protein 1 functions in concert with the Wiskott-Aldrich syndrome protein to promote podosome array organization and chemotaxis in dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 186: 4805-18. PMID 21398607 DOI: 10.4049/Jimmunol.1003102 |
0.415 |
|
| 2011 |
Ibrahim SH, Akazawa Y, Cazanave SC, Bronk SF, Elmi NA, Werneburg NW, Billadeau DD, Gores GJ. Glycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosis. Journal of Hepatology. 54: 765-72. PMID 21147505 DOI: 10.1016/J.Jhep.2010.09.039 |
0.301 |
|
| 2010 |
Chen Z, Borek D, Padrick SB, Gomez TS, Metlagel Z, Ismail AM, Umetani J, Billadeau DD, Otwinowski Z, Rosen MK. Structure and control of the actin regulatory WAVE complex. Nature. 468: 533-8. PMID 21107423 DOI: 10.1038/Nature09623 |
0.354 |
|
| 2010 |
Kang N, Yaqoob U, Geng Z, Bloch K, Liu C, Gomez T, Billadeau D, Shah V. Focal adhesion assembly in myofibroblasts fosters a microenvironment that promotes tumor growth. The American Journal of Pathology. 177: 1888-900. PMID 20802179 DOI: 10.2353/Ajpath.2010.100187 |
0.355 |
|
| 2010 |
Schroeder B, Weller SG, Chen J, Billadeau D, McNiven MA. A Dyn2-CIN85 complex mediates degradative traffic of the EGFR by regulation of late endosomal budding. The Embo Journal. 29: 3039-53. PMID 20711168 DOI: 10.1038/Emboj.2010.190 |
0.365 |
|
| 2010 |
Jia D, Gomez TS, Metlagel Z, Umetani J, Otwinowski Z, Rosen MK, Billadeau DD. WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes. Proceedings of the National Academy of Sciences of the United States of America. 107: 10442-7. PMID 20498093 DOI: 10.1073/Pnas.0913293107 |
0.393 |
|
| 2010 |
Billadeau DD. T cell activation at the immunological synapse: vesicles emerge for LATer signaling. Science Signaling. 3: pe16. PMID 20460646 DOI: 10.1126/Scisignal.3121Pe16 |
0.458 |
|
| 2010 |
Yu B, Martins IR, Li P, Amarasinghe GK, Umetani J, Fernandez-Zapico ME, Billadeau DD, Machius M, Tomchick DR, Rosen MK. Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1. Cell. 140: 246-56. PMID 20141838 DOI: 10.1107/S0108767311097042 |
0.355 |
|
| 2010 |
Meng XW, Heldebrant MP, Flatten KS, Loegering DA, Dai H, Schneider PA, Gomez TS, Peterson KL, Trushin SA, Hess AD, Smith BD, Karp JE, Billadeau DD, Kaufmann SH. Protein kinase Cbeta modulates ligand-induced cell surface death receptor accumulation: a mechanistic basis for enzastaurin-death ligand synergy. The Journal of Biological Chemistry. 285: 888-902. PMID 19887445 DOI: 10.1074/Jbc.M109.057638 |
0.377 |
|
| 2010 |
Billadeau DD. Vav proteins in cancer The Rho Gtpases in Cancer. 77-92. DOI: 10.1007/978-1-4419-1111-7_5 |
0.333 |
|
| 2009 |
Gomez TS, Billadeau DD. A FAM21-containing WASH complex regulates retromer-dependent sorting. Developmental Cell. 17: 699-711. PMID 19922874 DOI: 10.1016/J.Devcel.2009.09.009 |
0.411 |
|
| 2009 |
Bilim V, Ougolkov A, Yuuki K, Naito S, Kawazoe H, Muto A, Oya M, Billadeau D, Motoyama T, Tomita Y. Glycogen synthase kinase-3: a new therapeutic target in renal cell carcinoma. British Journal of Cancer. 101: 2005-14. PMID 19920820 DOI: 10.1038/Sj.Bjc.6605437 |
0.336 |
|
| 2009 |
Carrizosa E, Gomez TS, Labno CM, Klos Dehring DA, Liu X, Freedman BD, Billadeau DD, Burkhardt JK. Hematopoietic lineage cell-specific protein 1 is recruited to the immunological synapse by IL-2-inducible T cell kinase and regulates phospholipase Cgamma1 Microcluster dynamics during T cell spreading. Journal of Immunology (Baltimore, Md. : 1950). 183: 7352-61. PMID 19917685 DOI: 10.4049/Jimmunol.0900973 |
0.467 |
|
| 2009 |
Miletic AV, Graham DB, Sakata-Sogawa K, Hiroshima M, Hamann MJ, Cemerski S, Kloeppel T, Billadeau DD, Kanagawa O, Tokunaga M, Swat W. Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activity. Plos One. 4: e6599. PMID 19672294 DOI: 10.1371/Journal.Pone.0006599 |
0.464 |
|
| 2009 |
Segovis CM, Schoon RA, Dick CJ, Nacusi LP, Leibson PJ, Billadeau DD. PI3K links NKG2D signaling to a CrkL pathway involved in natural killer cell adhesion, polarity, and granule secretion. Journal of Immunology (Baltimore, Md. : 1950). 182: 6933-42. PMID 19454690 DOI: 10.4049/Jimmunol.0803840 |
0.788 |
|
| 2009 |
Tapadar S, He R, Luchini DN, Billadeau DD, Kozikowski AP. Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: Effects on HDAC biology and antiproliferative activity Bioorganic and Medicinal Chemistry Letters. 19: 3023-3026. PMID 19419863 DOI: 10.1016/J.Bmcl.2009.04.058 |
0.302 |
|
| 2009 |
Gaisina IN, Gallier F, Ougolkov AV, Kim KH, Kurome T, Guo S, Holzle D, Luchini DN, Blond SY, Billadeau DD, Kozikowski AP. From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3βinhibitors that suppress proliferation and survival of pancreatic cancer cells Journal of Medicinal Chemistry. 52: 1853-1863. PMID 19338355 DOI: 10.1021/Jm801317H |
0.322 |
|
| 2008 |
Ougolkov AV, Billadeau DD. Inhibition of glycogen synthase kinase-3. Methods in Molecular Biology (Clifton, N.J.). 468: 67-75. PMID 19099246 DOI: 10.1007/978-1-59745-249-6_5 |
0.383 |
|
| 2008 |
Arneson LN, Segovis CM, Gomez TS, Schoon RA, Dick CJ, Lou Z, Billadeau DD, Leibson PJ. Dynamin 2 regulates granule exocytosis during NK cell-mediated cytotoxicity. Journal of Immunology (Baltimore, Md. : 1950). 181: 6995-7001. PMID 18981119 DOI: 10.4049/Jimmunol.181.10.6995 |
0.78 |
|
| 2008 |
Ougolkov AV, Bilim VN, Billadeau DD. Regulation of pancreatic tumor cell proliferation and chemoresistance by the histone methyltransferase enhancer of zeste homologue 2. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 6790-6. PMID 18980972 DOI: 10.1158/1078-0432.Ccr-08-1013 |
0.36 |
|
| 2008 |
Nolz JC, Nacusi LP, Segovis CM, Medeiros RB, Mitchell JS, Shimizu Y, Billadeau DD. The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1. The Journal of Cell Biology. 182: 1231-44. PMID 18809728 DOI: 10.1083/Jcb.200801121 |
0.762 |
|
| 2008 |
Billadeau DD. PTEN gives neutrophils direction. Nature Immunology. 9: 716-8. PMID 18563079 DOI: 10.1038/Ni0708-716 |
0.372 |
|
| 2008 |
Gomez TS, Billadeau DD. T cell activation and the cytoskeleton: you can't have one without the other. Advances in Immunology. 97: 1-64. PMID 18501768 DOI: 10.1016/S0065-2776(08)00001-1 |
0.48 |
|
| 2008 |
Chen Y, Lopez-Sanchez M, Savoy DN, Billadeau DD, Dow GS, Kozikowski AP. A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum Journal of Medicinal Chemistry. 51: 3437-3448. PMID 18494463 DOI: 10.1021/Jm701606B |
0.316 |
|
| 2008 |
Goodell JR, Ougolkov AV, Hiasa H, Kaur H, Remmel R, Billadeau DD, Ferguson DM. Acridine-based agents with topoisomerase II activity inhibit pancreatic cancer cell proliferation and induce apoptosis. Journal of Medicinal Chemistry. 51: 179-82. PMID 18163538 DOI: 10.1021/Jm701228E |
0.365 |
|
| 2008 |
Colomba A, Courilleau D, Ramel D, Billadeau DD, Espinos E, Delsol G, Payrastre B, Gaits-Iacovoni F. Activation of Rac1 and the exchange factor Vav3 are involved in NPM-ALK signaling in anaplastic large cell lymphomas Oncogene. 27: 2728-2736. PMID 17998938 DOI: 10.1038/sj.onc.1210921 |
0.361 |
|
| 2007 |
Ramaswamy M, Dumont C, Cruz AC, Muppidi JR, Gomez TS, Billadeau DD, Tybulewicz VL, Siegel RM. Cutting edge: Rac GTPases sensitize activated T cells to die via Fas. Journal of Immunology (Baltimore, Md. : 1950). 179: 6384-8. PMID 17982024 DOI: 10.4049/Jimmunol.179.10.6384 |
0.427 |
|
| 2007 |
Billadeau DD. Primers on molecular pathways. The glycogen synthase kinase-3beta. Pancreatology : Official Journal of the International Association of Pancreatology (Iap) ... [Et Al.]. 7: 398-402. PMID 17912008 DOI: 10.1159/000108955 |
0.361 |
|
| 2007 |
Nolz JC, Fernandez-Zapico ME, Billadeau DD. TCR/CD28-stimulated actin dynamics are required for NFAT1-mediated transcription of c-rel leading to CD28 response element activation. Journal of Immunology (Baltimore, Md. : 1950). 179: 1104-12. PMID 17617603 DOI: 10.4049/Jimmunol.179.2.1104 |
0.396 |
|
| 2007 |
Nolz JC, Medeiros RB, Mitchell JS, Zhu P, Freedman BD, Shimizu Y, Billadeau DD. WAVE2 regulates high-affinity integrin binding by recruiting vinculin and talin to the immunological synapse. Molecular and Cellular Biology. 27: 5986-6000. PMID 17591693 DOI: 10.1128/Mcb.00136-07 |
0.416 |
|
| 2007 |
Ougolkov AV, Bone ND, Fernandez-Zapico ME, Kay NE, Billadeau DD. Inhibition of glycogen synthase kinase-3 activity leads to epigenetic silencing of nuclear factor kappaB target genes and induction of apoptosis in chronic lymphocytic leukemia B cells. Blood. 110: 735-42. PMID 17463171 DOI: 10.1182/Blood-2006-12-060947 |
0.405 |
|
| 2007 |
Gomez TS, Kumar K, Medeiros RB, Shimizu Y, Leibson PJ, Billadeau DD. Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse. Immunity. 26: 177-90. PMID 17306570 DOI: 10.1016/J.Immuni.2007.01.008 |
0.326 |
|
| 2007 |
Billadeau DD, Nolz JC, Gomez TS. Regulation of T-cell activation by the cytoskeleton. Nature Reviews. Immunology. 7: 131-43. PMID 17259969 DOI: 10.1038/Nri2021 |
0.473 |
|
| 2007 |
Hamann MJ, Lubking CM, Luchini DN, Billadeau DD. Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element. Molecular and Cellular Biology. 27: 1380-93. PMID 17145773 DOI: 10.1128/Mcb.01608-06 |
0.359 |
|
| 2007 |
Ming W, Li S, Billadeau DD, Quilliam LA, Dinauer MC. The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity. Molecular and Cellular Biology. 27: 312-23. PMID 17060455 DOI: 10.1128/Mcb.00985-06 |
0.317 |
|
| 2007 |
Ougolkov AV, Fernandez-Zapico ME, Billadeau DD. THE EZH2 HISTONE METHYLTRANSFERASE CONTRIBUTES TO PANCREATIC CANCER CELL PROLIFERATION THROUGH EPIGENETIC SILENCING OF CDK INHIBITOR GENES Pancreas. 35: 420-421. DOI: 10.1097/01.Mpa.0000297762.74831.39 |
0.324 |
|
| 2007 |
Billadeau DD, Long E, Lanier LL. Paul J. Leibson 1952–2007 Immunity. 27: 531-532. DOI: 10.1016/J.Immuni.2007.09.004 |
0.481 |
|
| 2006 |
Billadeau DD, Chatterjee S, Bramati P, Sreekumar R, Shah V, Hedin K, Urrutia R. Characterization of the CXCR4 signaling in pancreatic cancer cells. International Journal of Gastrointestinal Cancer. 37: 110-9. PMID 18175225 DOI: 10.1007/S12029-007-0011-7 |
0.403 |
|
| 2006 |
Miletic AV, Sakata-Sogawa K, Hiroshima M, Hamann MJ, Gomez TS, Ota N, Kloeppel T, Kanagawa O, Tokunaga M, Billadeau DD, Swat W. Vav1 acidic region tyrosine 174 is required for the formation of T cell receptor-induced microclusters and is essential in T cell development and activation. The Journal of Biological Chemistry. 281: 38257-65. PMID 17050525 DOI: 10.1074/Jbc.M608913200 |
0.462 |
|
| 2006 |
Billadeau DD, Burkhardt JK. Regulation of cytoskeletal dynamics at the immune synapse: new stars join the actin troupe. Traffic (Copenhagen, Denmark). 7: 1451-60. PMID 16984404 DOI: 10.1111/J.1600-0854.2006.00491.X |
0.463 |
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| 2006 |
Ougolkov AV, Fernandez-Zapico ME, Bilim VN, Smyrk TC, Chari ST, Billadeau DD. Aberrant nuclear accumulation of glycogen synthase kinase-3beta in human pancreatic cancer: association with kinase activity and tumor dedifferentiation. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 5074-81. PMID 16951223 DOI: 10.1158/1078-0432.Ccr-06-0196 |
0.342 |
|
| 2006 |
Gomez TS, McCarney SD, Carrizosa E, Labno CM, Comiskey EO, Nolz JC, Zhu P, Freedman BD, Clark MR, Rawlings DJ, Billadeau DD, Burkhardt JK. HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse. Immunity. 24: 741-52. PMID 16782030 DOI: 10.1016/J.Immuni.2006.03.022 |
0.439 |
|
| 2006 |
Upshaw JL, Arneson LN, Schoon RA, Dick CJ, Billadeau DD, Leibson PJ. NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells. Nature Immunology. 7: 524-32. PMID 16582911 DOI: 10.1038/Ni1325 |
0.457 |
|
| 2006 |
Ougolkov AV, Billadeau DD. Targeting GSK-3: a promising approach for cancer therapy? Future Oncology (London, England). 2: 91-100. PMID 16556076 DOI: 10.2217/14796694.2.1.91 |
0.344 |
|
| 2006 |
Nolz JC, Gomez TS, Zhu P, Li S, Medeiros RB, Shimizu Y, Burkhardt JK, Freedman BD, Billadeau DD. The WAVE2 complex regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation. Current Biology : Cb. 16: 24-34. PMID 16401421 DOI: 10.1016/J.Cub.2005.11.036 |
0.442 |
|
| 2006 |
Ougolkov AV, Bone N, Billadeau D, Lee YK, Kay NE. Inhibition of GSK-3 Induces Apoptosis of CLL Cells by Abrogating NFkB Nuclear Activity. Blood. 108: 2797-2797. DOI: 10.1182/Blood.V108.11.2797.2797 |
0.436 |
|
| 2005 |
Nolz JC, Gomez TS, Billadeau DD. The Ezh2 methyltransferase complex: actin up in the cytosol. Trends in Cell Biology. 15: 514-7. PMID 16126384 DOI: 10.1016/J.Tcb.2005.08.003 |
0.375 |
|
| 2005 |
Medeiros RB, Dickey DM, Chung H, Quale AC, Nagarajan LR, Billadeau DD, Shimizu Y. Protein kinase D1 and the beta 1 integrin cytoplasmic domain control beta 1 integrin function via regulation of Rap1 activation. Immunity. 23: 213-26. PMID 16111639 DOI: 10.1016/J.Immuni.2005.07.006 |
0.392 |
|
| 2005 |
Cejas PJ, Carlson LM, Kolonias D, Zhang J, Lindner I, Billadeau DD, Boise LH, Lee KP. Regulation of RelB expression during the initiation of dendritic cell differentiation. Molecular and Cellular Biology. 25: 7900-16. PMID 16107733 DOI: 10.1128/Mcb.25.17.7900-7916.2005 |
0.386 |
|
| 2005 |
Shakoori A, Ougolkov A, Yu ZW, Zhang B, Modarressi MH, Billadeau DD, Mai M, Takahashi Y, Minamoto T. Deregulated GSK3beta activity in colorectal cancer: its association with tumor cell survival and proliferation. Biochemical and Biophysical Research Communications. 334: 1365-73. PMID 16043125 DOI: 10.1016/J.Bbrc.2005.07.041 |
0.398 |
|
| 2005 |
Upshaw JL, Schoon RA, Dick CJ, Billadeau DD, Leibson PJ. The isoforms of phospholipase C-gamma are differentially used by distinct human NK activating receptors. Journal of Immunology (Baltimore, Md. : 1950). 175: 213-8. PMID 15972651 DOI: 10.4049/Jimmunol.175.1.213 |
0.35 |
|
| 2005 |
Ougolkov AV, Fernandez-Zapico ME, Savoy DN, Urrutia RA, Billadeau DD. Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells. Cancer Research. 65: 2076-81. PMID 15781615 DOI: 10.1158/0008-5472.Can-04-3642 |
0.346 |
|
| 2005 |
Charvet C, Canonigo AJ, Billadeau DD, Altman A. Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76. The Journal of Biological Chemistry. 280: 15289-99. PMID 15708849 DOI: 10.1074/jbc.M500275200 |
0.34 |
|
| 2005 |
Gomez TS, Hamann MJ, McCarney S, Savoy DN, Lubking CM, Heldebrant MP, Labno CM, McKean DJ, McNiven MA, Burkhardt JK, Billadeau DD. Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse. Nature Immunology. 6: 261-70. PMID 15696170 DOI: 10.1038/Ni1168 |
0.476 |
|
| 2005 |
Dombroski D, Houghtling RA, Labno CM, Precht P, Takesono A, Caplen NJ, Billadeau DD, Wange RL, Burkhardt JK, Schwartzberg PL. Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton. Journal of Immunology (Baltimore, Md. : 1950). 174: 1385-92. PMID 15661896 DOI: 10.4049/Jimmunol.174.3.1385 |
0.417 |
|
| 2005 |
Fernandez-Zapico ME, Gonzalez-Paz NC, Weiss E, Savoy DN, Molina JR, Fonseca R, Smyrk TC, Chari ST, Urrutia R, Billadeau DD. Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis. Cancer Cell. 7: 39-49. PMID 15652748 DOI: 10.1016/J.Ccr.2004.11.024 |
0.394 |
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| 2005 |
Kim JE, Billadeau DD, Chen J. The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis. The Journal of Biological Chemistry. 280: 5733-9. PMID 15545273 DOI: 10.1074/Jbc.M409298200 |
0.659 |
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| 2005 |
Ougolkov AV, Savoy DN, Fernandez-Zapico ME, Urrutia R, Smyrk TC, Chari ST, Billadeau DD. NUCLEAR ACCUMULATION OF ACTIVE GSK-3?? CONTRIBUTES TO NF??B-MEDIATED PANCREATIC CANCER CELL SURVIVAL AND PROLIFERATION Pancreas. 31: 461. DOI: 10.1097/01.Mpa.0000193736.49910.78 |
0.376 |
|
| 2005 |
Hamann MJ, Gomez TS, Savoy DN, Billadeau DD. ASEF2 EXCHANGE ACTIVITY IS STIMULATED BY DYNAMIN2 AND PROMOTES TUMOR CELL POLARIZATION Pancreas. 31: 444. DOI: 10.1097/01.Mpa.0000193677.55267.76 |
0.336 |
|
| 2004 |
Pearce AC, Senis YA, Billadeau DD, Turner M, Watson SP, Vigorito E. Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen. The Journal of Biological Chemistry. 279: 53955-62. PMID 15456756 DOI: 10.1074/Jbc.M410355200 |
0.398 |
|
| 2004 |
Chen XM, Splinter PL, Tietz PS, Huang BQ, Billadeau DD, LaRusso NF. Phosphatidylinositol 3-kinase and frabin mediate Cryptosporidium parvum cellular invasion via activation of Cdc42. The Journal of Biological Chemistry. 279: 31671-8. PMID 15133042 DOI: 10.1074/Jbc.M401592200 |
0.402 |
|
| 2004 |
Chen XM, Huang BQ, Splinter PL, Orth JD, Billadeau DD, McNiven MA, LaRusso NF. Cdc42 and the actin-related protein/neural Wiskott-Aldrich syndrome protein network mediate cellular invasion by Cryptosporidium parvum. Infection and Immunity. 72: 3011-21. PMID 15102814 DOI: 10.1128/Iai.72.5.3011-3021.2004 |
0.402 |
|
| 2004 |
Zakaria S, Gomez TS, Savoy DN, McAdam S, Turner M, Abraham RT, Billadeau DD. Differential regulation of TCR-mediated gene transcription by Vav family members. The Journal of Experimental Medicine. 199: 429-34. PMID 14757747 DOI: 10.1084/Jem.20031228 |
0.437 |
|
| 2004 |
Hamann M, Nolz J, Gomez T, Billadeau D. THE INTERACTION OF VAV1 AND THE TYROSINE PHOSPHATASE SHP-1 IDENTIFIES A MECHANISM FOR UNCONTROLLED GEF ACTIVITY IN PANCREATIC CANCER CELLS. Pancreas. 29: 359. DOI: 10.1097/00006676-200411000-00127 |
0.378 |
|
| 2003 |
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV. Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes. Molecular and Cellular Biology. 23: 7068-81. PMID 12972622 DOI: 10.1128/Mcb.23.19.7068-7081.2003 |
0.415 |
|
| 2003 |
Stebbins CC, Watzl C, Billadeau DD, Leibson PJ, Burshtyn DN, Long EO. Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity. Molecular and Cellular Biology. 23: 6291-9. PMID 12917349 DOI: 10.1128/Mcb.23.17.6291-6299.2003 |
0.488 |
|
| 2003 |
Zeng R, Cannon JL, Abraham RT, Way M, Billadeau DD, Bubeck-Wardenberg J, Burkhardt JK. SLP-76 coordinates Nck-dependent Wiskott-Aldrich syndrome protein recruitment with Vav-1/Cdc42-dependent Wiskott-Aldrich syndrome protein activation at the T cell-APC contact site. Journal of Immunology (Baltimore, Md. : 1950). 171: 1360-8. PMID 12874226 DOI: 10.4049/Jimmunol.171.3.1360 |
0.42 |
|
| 2003 |
Zhang M, Kalinec GM, Urrutia R, Billadeau DD, Kalinec F. ROCK-dependent and ROCK-independent control of cochlear outer hair cell electromotility. The Journal of Biological Chemistry. 278: 35644-50. PMID 12837763 DOI: 10.1074/Jbc.M301668200 |
0.427 |
|
| 2003 |
Billadeau DD, Upshaw JL, Schoon RA, Dick CJ, Leibson PJ. NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway. Nature Immunology. 4: 557-64. PMID 12740575 DOI: 10.1038/Ni929 |
0.452 |
|
| 2002 |
Billadeau DD. Cell growth and metastasis in pancreatic cancer: is Vav the Rho'd to activation? International Journal of Gastrointestinal Cancer. 31: 5-13. PMID 12622410 DOI: 10.1385/Ijgc:31:1-3:5 |
0.425 |
|
| 2002 |
Cao Y, Janssen EM, Duncan AW, Altman A, Billadeau DD, Abraham RT. Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line. The Embo Journal. 21: 4809-19. PMID 12234921 DOI: 10.1093/Emboj/Cdf499 |
0.458 |
|
| 2002 |
Turner M, Billadeau DD. VAV proteins as signal integrators for multi-subunit immune-recognition receptors. Nature Reviews. Immunology. 2: 476-86. PMID 12094222 DOI: 10.1038/Nri840 |
0.388 |
|
| 2002 |
Billadeau DD, Leibson PJ. ITAMs versus ITIMs: striking a balance during cell regulation. The Journal of Clinical Investigation. 109: 161-8. PMID 11805126 DOI: 10.1172/Jci14843 |
0.457 |
|
| 2001 |
Lou Z, Billadeau DD, Savoy DN, Schoon RA, Leibson PJ. A role for a RhoA/ROCK/LIM-kinase pathway in the regulation of cytotoxic lymphocytes Journal of Immunology. 167: 5749-5757. PMID 11698448 DOI: 10.4049/Jimmunol.167.10.5749 |
0.432 |
|
| 2001 |
Jevremovic D, Billadeau DD, Schoon RA, Dick CJ, Leibson PJ. Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2. Journal of Immunology (Baltimore, Md. : 1950). 166: 7219-28. PMID 11390470 DOI: 10.4049/Jimmunol.166.12.7219 |
0.476 |
|
| 2000 |
Doody GM, Billadeau DD, Clayton E, Hutchings A, Berland R, McAdam S, Leibson PJ, Turner M. Vav-2 controls NFAT-dependent transcription in B- but not T-lymphocytes Embo Journal. 19: 6173-6184. PMID 11080163 DOI: 10.1093/Emboj/19.22.6173 |
0.452 |
|
| 2000 |
Billadeau DD, Mackie SM, Schoon RA, Leibson PJ. The Rho family guanine nucleotide exchange factor Vav-2 regulates the development of cell-mediated cytotoxicity Journal of Experimental Medicine. 192: 381-391. PMID 10934226 DOI: 10.1084/Jem.192.3.381 |
0.497 |
|
| 2000 |
Billadeau DD, Mackie SM, Schoon RA, Leibson PJ. Specific subdomains of Vav differentially affect T cell and NK cell activation Journal of Immunology. 164: 3971-3981. PMID 10754287 DOI: 10.4049/Jimmunol.164.8.3971 |
0.425 |
|
| 2000 |
Savoy DN, Billadeau DD, Leibson PJ. Cutting edge: WIP, a binding partner for Wiskott-Aldrich syndrome protein, cooperates with Vav in the regulation of T cell activation Journal of Immunology. 164: 2866-2870. PMID 10706671 DOI: 10.4049/Jimmunol.164.6.2866 |
0.441 |
|
| 2000 |
Lou Z, Jevremovic D, Billadeau DD, Leibson PJ. A balance between positive and negative signals in cytotoxic lymphocytes regulates the polarization of lipid rafts during the development of cell-mediated killing. The Journal of Experimental Medicine. 191: 347-54. PMID 10637278 DOI: 10.1084/Jem.191.2.347 |
0.484 |
|
| 1999 |
Jevremovic D, Billadeau DD, Schoon RA, Dick CJ, Irvin BJ, Zhang W, Samelson LE, Abraham RT, Leibson PJ. Cutting edge: a role for the adaptor protein LAT in human NK cell-mediated cytotoxicity. Journal of Immunology (Baltimore, Md. : 1950). 162: 2453-6. PMID 10072481 |
0.355 |
|
| 1998 |
Binstadt BA, Billadeau DD, Jevremović D, Williams BL, Fang N, Yi T, Koretzky GA, Abraham RT, Leibson PJ. SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors. The Journal of Biological Chemistry. 273: 27518-23. PMID 9765283 DOI: 10.1074/Jbc.273.42.27518 |
0.37 |
|
| 1998 |
Billadeau DD, Brumbaugh KM, Dick CJ, Schoon RA, Bustelo XR, Leibson PJ. The Vav-Rac1 pathway in cytotoxic lymphocytes regulates the generation of cell-mediated killing Journal of Experimental Medicine. 188: 549-559. PMID 9687532 DOI: 10.1084/Jem.188.3.549 |
0.495 |
|
| 1998 |
Billadeau DD, Brumbaugh KM, Leibson PJ. Regulation of NK cell-mediated cytotoxicity by the VAV-RAC1 pathway Faseb Journal. 12. |
0.407 |
|
| 1997 |
Brumbaugh KM, Binstadt BA, Billadeau DD, Schoon RA, Dick CJ, Ten RM, Leibson PJ. Functional role for Syk tyrosine kinase in natural killer cell-mediated natural cytotoxicity Journal of Experimental Medicine. 186: 1965-1974. PMID 9396765 DOI: 10.1084/Jem.186.12.1965 |
0.448 |
|
| 1997 |
Kay NE, Leong T, Kyle RA, Greipp P, Billadeau D, Ness BV, Bone N, Oken MM. Circulating Blood B Cells in Multiple Myeloma: Analysis and Relationship to Circulating Clonal Cells and Clinical Parameters in a Cohort of Patients Entered on the Eastern Cooperative Oncology Group Phase III E9486 Clinical Trial Blood. 90: 340-345. DOI: 10.1182/Blood.V90.1.340 |
0.323 |
|
| 1996 |
Billadeau D, Ness BV, Kimlinger T, Kyle R, Therneau T, Greipp P, Witzig T. Clonal Circulating Cells Are Common in Plasma Cell Proliferative Disorders: A Comparison of Monoclonal Gammopathy of Undetermined Significance, Smoldering Multiple Myeloma, and Active Myeloma Blood. 88: 289-296. DOI: 10.1182/Blood.V88.1.289.Bloodjournal881289 |
0.342 |
|
| 1993 |
Billadeau D, Ahmann G, Greipp P, Ness BV. The bone marrow of multiple myeloma patients contains B cell populations at different stages of differentiation that are clonally related to the malignant plasma cell. Journal of Experimental Medicine. 178: 1023-1031. PMID 8350044 DOI: 10.1084/Jem.178.3.1023 |
0.33 |
|
| 1992 |
Billadeau D, Quam L, Thomas W, Kay N, Greipp P, Kyle R, Oken M, Ness BV. Detection and quantitation of malignant cells in the peripheral blood of multiple myeloma patients. Blood. 80: 1818-1824. DOI: 10.1182/Blood.V80.7.1818.Bloodjournal8071818 |
0.304 |
|
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