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Kevin A. Reynolds - Publications

Affiliations: 
1989-1997 Pharmaceutical Sciences University of Maryland at Baltimore, Baltimore, MD, United States 
 2000-2005 Medicinal Chemistry Virginia Commonwealth University, Richmond, VA, United States 
 2005- Chemistry Portland State University, Portland, OR, United States 
Area:
Pharmaceutical Chemistry, Microbiology Biology, Molecular Biology, Biochemistry
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Year Citation  Score
2017 Lu W, Kancharla P, Reynolds KA. MarH, a Bifunctional Enzyme Involved in the Condensation and Hydroxylation Steps of the Marineosin Biosynthetic Pathway. Organic Letters. PMID 28271893 DOI: 10.1021/Acs.Orglett.7B00093  0.457
2016 Kancharla P, Bonnett S, Reynolds K. Stenotrophomonas maltophilia OleC Catalyzed ATP-Dependent Formation of Long Chain Z-Olefins from 2-Alkyl-3-hydroxyalkanoic Acids. Chembiochem : a European Journal of Chemical Biology. PMID 27238740 DOI: 10.1002/Cbic.201600063  0.441
2016 Singh R, Reynolds KA. Identification and Characterization of FabA from the Type II Fatty Acid Synthase of Streptomyces coelicolor. Journal of Natural Products. 79: 240-3. PMID 26731437 DOI: 10.1021/Acs.Jnatprod.5B00560  0.462
2015 Kancharla P, Kelly JX, Reynolds KA. Synthesis and Structure-Activity Relationships of Tambjamines and B-Ring Functionalized Prodiginines as Potent Antimalarials. Journal of Medicinal Chemistry. 58: 7286-309. PMID 26305125 DOI: 10.1021/Acs.Jmedchem.5B00560  0.321
2015 Polikanov YS, Starosta AL, Juette MF, Altman RB, Terry DS, Lu W, Burnett BJ, Dinos G, Reynolds KA, Blanchard SC, Steitz TA, Wilson DN. Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A. Molecular Cell. 58: 832-44. PMID 26028538 DOI: 10.1016/J.Molcel.2015.04.014  0.339
2015 Singh R, Reynolds KA. Characterization of FabG and FabI of the Streptomyces coelicolor dissociated fatty acid synthase. Chembiochem : a European Journal of Chemical Biology. 16: 631-40. PMID 25662938 DOI: 10.1002/Cbic.201402670  0.451
2014 Kancharla P, Lu W, Salem SM, Kelly JX, Reynolds KA. Stereospecific synthesis of 23-hydroxyundecylprodiginines and analogues and conversion to antimalarial premarineosins via a Rieske oxygenase catalyzed bicyclization. The Journal of Organic Chemistry. 79: 11674-89. PMID 25380131 DOI: 10.1021/Jo5023553  0.385
2014 Salem SM, Kancharla P, Florova G, Gupta S, Lu W, Reynolds KA. Elucidation of final steps of the marineosins biosynthetic pathway through identification and characterization of the corresponding gene cluster. Journal of the American Chemical Society. 136: 4565-74. PMID 24575817 DOI: 10.1021/Ja411544W  0.405
2014 Yamanaka K, Reynolds KA, Kersten RD, Ryan KS, Gonzalez DJ, Nizet V, Dorrestein PC, Moore BS. Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A. Proceedings of the National Academy of Sciences of the United States of America. 111: 1957-62. PMID 24449899 DOI: 10.1073/Pnas.1319584111  0.508
2013 Bonnett SA, Whicher JR, Papireddy K, Florova G, Smith JL, Reynolds KA. Structural and stereochemical analysis of a modular polyketide synthase ketoreductase domain required for the generation of a cis-alkene. Chemistry & Biology. 20: 772-83. PMID 23790488 DOI: 10.1016/J.Chembiol.2013.04.014  0.384
2013 Kancharla P, Reynolds KA. Synthesis of 2,2′-bipyrrole-5-carboxaldehydes and their application in the synthesis of B-ring functionalized prodiginines and tambjamines Tetrahedron. 69: 8375-8385. DOI: 10.1016/J.Tet.2013.07.067  0.32
2012 Yan J, Hazzard C, Bonnett SA, Reynolds KA. Functional modular dissection of DEBS1-TE changes triketide lactone ratios and provides insight into Acyl group loading, hydrolysis, and ACP transfer. Biochemistry. 51: 9333-41. PMID 23116287 DOI: 10.1021/Bi300830Q  0.316
2012 Singh R, Mo S, Florova G, Reynolds KA. Streptomyces coelicolor RedP and FabH enzymes, initiating undecylprodiginine and fatty acid biosynthesis, exhibit distinct acyl-CoA and malonyl-acyl carrier protein substrate specificities. Fems Microbiology Letters. 328: 32-8. PMID 22136753 DOI: 10.1111/J.1574-6968.2011.02474.X  0.505
2011 Bonnett SA, Papireddy K, Higgins S, del Cardayre S, Reynolds KA. Functional characterization of an NADPH dependent 2-alkyl-3-ketoalkanoic acid reductase involved in olefin biosynthesis in Stenotrophomonas maltophilia. Biochemistry. 50: 9633-40. PMID 21958090 DOI: 10.1021/Bi201096W  0.481
2011 Bonnett SA, Rath CM, Shareef AR, Joels JR, Chemler JA, Håkansson K, Reynolds K, Sherman DH. Acyl-CoA subunit selectivity in the pikromycin polyketide synthase PikAIV: steady-state kinetics and active-site occupancy analysis by FTICR-MS. Chemistry & Biology. 18: 1075-81. PMID 21944746 DOI: 10.1016/J.Chembiol.2011.07.016  0.374
2011 Papireddy K, Smilkstein M, Kelly JX, Shweta, Salem SM, Alhamadsheh M, Haynes SW, Challis GL, Reynolds KA. Antimalarial activity of natural and synthetic prodiginines. Journal of Medicinal Chemistry. 54: 5296-306. PMID 21736388 DOI: 10.1021/Jm200543Y  0.697
2011 Whicher JR, Florova G, Sydor PK, Singh R, Alhamadsheh M, Challis GL, Reynolds KA, Smith JL. Structure and function of the RedJ protein, a thioesterase from the prodiginine biosynthetic pathway in Streptomyces coelicolor. The Journal of Biological Chemistry. 286: 22558-69. PMID 21543318 DOI: 10.1074/Jbc.M110.213512  0.768
2010 MOORE BS, CHO H, CASATI R, KENNEDY E, REYNOLDS KA, MOCEK U, BEALE JM, FLOSS HG. ChemInform Abstract: Biosynthetic Studies on Ansatrienin A. Formation of the Cyclohexanecarboxylic Acid Moiety. Cheminform. 24: no-no. DOI: 10.1002/chin.199343249  0.512
2009 Palaniappan N, Dhote V, Ayers S, Starosta AL, Wilson DN, Reynolds KA. Biosynthesis of the aminocyclitol subunit of hygromycin A in Streptomyces hygroscopicus NRRL 2388. Chemistry & Biology. 16: 1180-9. PMID 19942141 DOI: 10.1016/J.Chembiol.2009.10.013  0.419
2009 Dhote V, Starosta AL, Wilson DN, Reynolds KA. The final step of hygromycin A biosynthesis, oxidation of C-5''-dihydrohygromycin A, is linked to a putative proton gradient-dependent efflux. Antimicrobial Agents and Chemotherapy. 53: 5163-72. PMID 19770276 DOI: 10.1128/Aac.01069-09  0.45
2009 Liu Y, Hazzard C, Eustáquio AS, Reynolds KA, Moore BS. Biosynthesis of salinosporamides from alpha,beta-unsaturated fatty acids: implications for extending polyketide synthase diversity. Journal of the American Chemical Society. 131: 10376-7. PMID 19601645 DOI: 10.1021/Ja9042824  0.591
2009 Li C, Hazzard C, Florova G, Reynolds KA. High titer production of tetracenomycins by heterologous expression of the pathway in a Streptomyces cinnamonensis industrial monensin producer strain. Metabolic Engineering. 11: 319-27. PMID 19595787 DOI: 10.1016/J.Ymben.2009.06.004  0.777
2009 Eustáquio AS, McGlinchey RP, Liu Y, Hazzard C, Beer LL, Florova G, Alhamadsheh MM, Lechner A, Kale AJ, Kobayashi Y, Reynolds KA, Moore BS. Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine. Proceedings of the National Academy of Sciences of the United States of America. 106: 12295-300. PMID 19590008 DOI: 10.1073/Pnas.0901237106  0.784
2009 Yan J, Gupta S, Sherman DH, Reynolds KA. Functional dissection of a multimodular polypeptide of the pikromycin polyketide synthase into monomodules by using a matched pair of heterologous docking domains. Chembiochem : a European Journal of Chemical Biology. 10: 1537-43. PMID 19437523 DOI: 10.1002/Cbic.200900098  0.337
2009 Ghatge MS, Palaniappan N, Alhamadsheh MM, DiBari J, Reynolds KA. Application of a newly identified and characterized 18-o-acyltransferase in chemoenzymatic synthesis of selected natural and nonnatural bioactive derivatives of phoslactomycins. Applied and Environmental Microbiology. 75: 3469-76. PMID 19304832 DOI: 10.1128/Aem.02590-08  0.753
2009 Buchholz TJ, Geders TW, Bartley FE, Reynolds KA, Smith JL, Sherman DH. Structural basis for binding specificity between subclasses of modular polyketide synthase docking domains. Acs Chemical Biology. 4: 41-52. PMID 19146481 DOI: 10.1021/Cb8002607  0.318
2008 Alhamadsheh MM, Waters NC, Sachdeva S, Lee P, Reynolds KA. Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 6402-5. PMID 18996691 DOI: 10.1016/J.Bmcl.2008.10.097  0.782
2008 Palaniappan N, Alhamadsheh MM, Reynolds KA. cis-Delta(2,3)-double bond of phoslactomycins is generated by a post-PKS tailoring enzyme. Journal of the American Chemical Society. 130: 12236-7. PMID 18714992 DOI: 10.1021/Ja8044162  0.751
2008 Dhote V, Gupta S, Reynolds KA. An O-phosphotransferase catalyzes phosphorylation of hygromycin A in the antibiotic-producing organism Streptomyces hygroscopicus. Antimicrobial Agents and Chemotherapy. 52: 3580-8. PMID 18644964 DOI: 10.1128/Aac.00157-08  0.334
2008 Turos E, Revell KD, Ramaraju P, Gergeres DA, Greenhalgh K, Young A, Sathyanarayan N, Dickey S, Lim D, Alhamadsheh MM, Reynolds K. Unsymmetric aryl-alkyl disulfide growth inhibitors of methicillin-resistant Staphylococcus aureus and Bacillus anthracis. Bioorganic & Medicinal Chemistry. 16: 6501-8. PMID 18524602 DOI: 10.1016/J.Bmc.2008.05.032  0.756
2008 Gupta S, Lakshmanan V, Kim BS, Fecik R, Reynolds KA. Generation of novel pikromycin antibiotic products through mutasynthesis. Chembiochem : a European Journal of Chemical Biology. 9: 1609-16. PMID 18512859 DOI: 10.1002/Cbic.200700635  0.399
2008 Sachdeva S, Reynolds KA. Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase III (mtFabH) assay: principles and method. Methods in Molecular Medicine. 142: 205-13. PMID 18437316 DOI: 10.1007/978-1-59745-246-5_16  0.769
2008 Sachdeva S, Musayev FN, Alhamadsheh MM, Scarsdale JN, Wright HT, Reynolds KA. Separate entrance and exit portals for ligand traffic in Mycobacterium tuberculosis FabH. Chemistry & Biology. 15: 402-12. PMID 18420147 DOI: 10.1016/J.Chembiol.2008.03.007  0.794
2008 Mo S, Sydor PK, Corre C, Alhamadsheh MM, Stanley AE, Haynes SW, Song L, Reynolds KA, Challis GL. Elucidation of the Streptomyces coelicolor pathway to 2-undecylpyrrole, a key intermediate in undecylprodiginine and streptorubin B biosynthesis. Chemistry & Biology. 15: 137-48. PMID 18291318 DOI: 10.1016/J.Chembiol.2007.11.015  0.765
2008 Sachdeva S, Musayev F, Alhamadsheh MM, Neel Scarsdale J, Tonie Wright H, Reynolds KA. Probing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substrates. Bioorganic Chemistry. 36: 85-90. PMID 18096200 DOI: 10.1016/J.Bioorg.2007.11.001  0.796
2007 Wright HT, Reynolds KA. Antibacterial targets in fatty acid biosynthesis. Current Opinion in Microbiology. 10: 447-53. PMID 17707686 DOI: 10.1016/J.Mib.2007.07.001  0.416
2007 Alhamadsheh MM, Musayev F, Komissarov AA, Sachdeva S, Wright HT, Scarsdale N, Florova G, Reynolds KA. Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes. Chemistry & Biology. 14: 513-24. PMID 17524982 DOI: 10.1016/J.Chembiol.2007.03.013  0.8
2007 Alhamadsheh MM, Palaniappan N, Daschouduri S, Reynolds KA. Modular polyketide synthases and cis double bond formation: establishment of activated cis-3-cyclohexylpropenoic acid as the diketide intermediate in phoslactomycin biosynthesis. Journal of the American Chemical Society. 129: 1910-1. PMID 17256943 DOI: 10.1021/Ja068818T  0.722
2007 Alhamadsheh MM, Waters NC, Huddler DP, Kreishman-Deitrick M, Florova G, Reynolds KA. Synthesis and biological evaluation of thiazolidine-2-one 1,1-dioxide as inhibitors of Escherichia coli beta-ketoacyl-ACP-synthase III (FabH). Bioorganic & Medicinal Chemistry Letters. 17: 879-83. PMID 17189694 DOI: 10.1016/J.Bmcl.2006.11.067  0.725
2007 Palaniappan N, Reynolds KA. Hygromycin a biosynthesis Acs Symposium Series. 955: 16-32.  0.316
2006 Palaniappan N, Ayers S, Gupta S, Habib el-S, Reynolds KA. Production of hygromycin A analogs in Streptomyces hygroscopicus NRRL 2388 through identification and manipulation of the biosynthetic gene cluster. Chemistry & Biology. 13: 753-64. PMID 16873023 DOI: 10.1016/J.Chembiol.2006.05.013  0.391
2006 Ghatge MS, Palaniappan N, Choudhuri SD, Reynolds KA. Genetic manipulation of the biosynthetic process leading to phoslactomycins, potent protein phosphatase 2A inhibitors Journal of Industrial Microbiology & Biotechnology. 33: 589-599. PMID 16609856 DOI: 10.1007/S10295-006-0116-1  0.446
2006 Li C, Akopiants K, Reynolds KA. Identification and disruptional analysis of the Streptomyces cinnamonensis msdA gene, encoding methylmalonic acid semialdehyde dehydrogenase. Journal of Industrial Microbiology & Biotechnology. 33: 75-83. PMID 16292556 DOI: 10.1007/S10295-005-0053-4  0.791
2006 Akopiants K, Florova G, Li C, Reynolds KA. Multiple pathways for acetate assimilation in Streptomyces cinnamonensis. Journal of Industrial Microbiology & Biotechnology. 33: 141-50. PMID 16187095 DOI: 10.1007/S10295-005-0029-4  0.805
2005 Choudhuri SD, Ayers S, Soine WH, Reynolds KA. A pH-stability study of phoslactomycin B and analysis of the acid and base degradation products. The Journal of Antibiotics. 58: 573-82. PMID 16323318 DOI: 10.1038/Ja.2005.78  0.391
2005 Ghatge MS, Reynolds KA. The plmS2-encoded cytochrome P450 monooxygenase mediates hydroxylation of phoslactomycin B in Streptomyces sp. strain HK803. Journal of Bacteriology. 187: 7970-6. PMID 16291670 DOI: 10.1128/Jb.187.23.7970-7976.2005  0.404
2005 Li Y, Florova G, Reynolds KA. Alteration of the fatty acid profile of Streptomyces coelicolor by replacement of the initiation enzyme 3-ketoacyl acyl carrier protein synthase III (FabH). Journal of Bacteriology. 187: 3795-9. PMID 15901703 DOI: 10.1128/Jb.187.11.3795-3799.2005  0.491
2005 Mo S, Kim BS, Reynolds KA. Production of branched-chain alkylprodiginines in S. coelicolor by replacement of the 3-ketoacyl ACP synthase III initiation enzyme, RedP. Chemistry & Biology. 12: 191-200. PMID 15734646 DOI: 10.1016/J.Chembiol.2004.11.006  0.493
2005 Musayev F, Sachdeva S, Scarsdale JN, Reynolds KA, Wright HT. Crystal structure of a substrate complex of Mycobacterium tuberculosis β-ketoacyl-acyl carrier protein synthase III (FabH) with lauroyl-coenzyme A Journal of Molecular Biology. 346: 1313-1321. PMID 15713483 DOI: 10.1016/J.Jmb.2004.12.044  0.763
2004 Li C, Florova G, Akopiants K, Reynolds KA. Crotonyl-coenzyme A reductase provides methylmalonyl-CoA precursors for monensin biosynthesis by Streptomyces cinnamonensis in an oil-based extended fermentation. Microbiology (Reading, England). 150: 3463-72. PMID 15470123 DOI: 10.1099/Mic.0.27251-0  0.806
2004 He X, Reeve AM, Desai UR, Kellogg GE, Reynolds KA. 1,2-dithiole-3-ones as potent inhibitors of the bacterial 3-ketoacyl acyl carrier protein synthase III (FabH). Antimicrobial Agents and Chemotherapy. 48: 3093-102. PMID 15273125 DOI: 10.1128/Aac.48.8.3093-3102.2004  0.447
2004 Kim BS, Sherman DH, Reynolds KA. An efficient method for creation and functional analysis of libraries of hybrid type I polyketide synthases. Protein Engineering, Design & Selection : Peds. 17: 277-84. PMID 15067106 DOI: 10.1093/Protein/Gzh032  0.309
2003 Beck BJ, Aldrich CC, Fecik RA, Reynolds KA, Sherman DH. Substrate recognition and channeling of monomodules from the pikromycin polyketide synthase. Journal of the American Chemical Society. 125: 12551-7. PMID 14531700 DOI: 10.1021/Ja034841S  0.406
2003 Brown MS, Akopiants K, Resceck DM, McArthur HA, McCormick E, Reynolds KA. Biosynthetic origins of the natural product, thiolactomycin: a unique and selective inhibitor of type II dissociated fatty acid synthases. Journal of the American Chemical Society. 125: 10166-7. PMID 12926927 DOI: 10.1021/Ja034540I  0.45
2003 Habib el-SE, Scarsdale JN, Reynolds KA. Biosynthetic origin of hygromycin A. Antimicrobial Agents and Chemotherapy. 47: 2065-71. PMID 12821448 DOI: 10.1128/Aac.47.7.2065-2071.2003  0.439
2003 Palaniappan N, Kim BS, Sekiyama Y, Osada H, Reynolds KA. Enhancement and selective production of phoslactomycin B, a protein phosphatase IIa inhibitor, through identification and engineering of the corresponding biosynthetic gene cluster. The Journal of Biological Chemistry. 278: 35552-7. PMID 12819191 DOI: 10.1074/Jbc.M305082200  0.408
2003 Beck BJ, Aldrich CC, Fecik RA, Reynolds KA, Sherman DH. Iterative chain elongation by a pikromycin monomodular polyketide synthase. Journal of the American Chemical Society. 125: 4682-3. PMID 12696866 DOI: 10.1021/Ja029974C  0.459
2003 Prigge ST, He X, Gerena L, Waters NC, Reynolds KA. The initiating steps of a type II fatty acid synthase in Plasmodium falciparum are catalyzed by pfACP, pfMCAT, and pfKASIII. Biochemistry. 42: 1160-9. PMID 12549938 DOI: 10.1021/Bi026847K  0.436
2003 Sekiyama Y, Palaniappan N, Reynolds KA, Osada H. Biosynthesis of phoslactomycins: Cyclohexanecarboxylic acid as the starter unit Tetrahedron. 59: 7465-7471. DOI: 10.1016/S0040-4020(03)01205-5  0.406
2002 Cropp TA, Kim BS, Beck BJ, Yoon YJ, Sherman DH, Reynolds KA. Recent developments in the production of novel polyketides by combinatorial biosynthesis. Biotechnology & Genetic Engineering Reviews. 19: 159-72. PMID 12520877 DOI: 10.1080/02648725.2002.10648028  0.32
2002 Kim BS, Cropp TA, Beck BJ, Sherman DH, Reynolds KA. Biochemical evidence for an editing role of thioesterase II in the biosynthesis of the polyketide pikromycin. The Journal of Biological Chemistry. 277: 48028-34. PMID 12368286 DOI: 10.1074/Jbc.M207770200  0.338
2002 Kim BS, Cropp TA, Florova G, Lindsay Y, Sherman DH, Reynolds KA. An unexpected interaction between the modular polyketide synthases, erythromycin DEBS1 and pikromycin PikAIV, leads to efficient triketide lactone synthesis. Biochemistry. 41: 10827-33. PMID 12196022 DOI: 10.1021/Bi0256779  0.39
2002 Florova G, Kazanina G, Reynolds KA. Enzymes involved in fatty acid and polyketide biosynthesis in Streptomyces glaucescens: role of FabH and FabD and their acyl carrier protein specificity. Biochemistry. 41: 10462-71. PMID 12173933 DOI: 10.1021/Bi0258804  0.442
2002 Beck BJ, Yoon YJ, Reynolds KA, Sherman DH. The hidden steps of domain skipping: macrolactone ring size determination in the pikromycin modular polyketide synthase. Chemistry & Biology. 9: 575-83. PMID 12031664 DOI: 10.1016/S1074-5521(02)00146-1  0.347
2002 He X, Reynolds KA. Purification, characterization, and identification of novel inhibitors of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus. Antimicrobial Agents and Chemotherapy. 46: 1310-8. PMID 11959561 DOI: 10.1128/Aac.46.5.1310-1318.2002  0.4
2002 Yoon YJ, Beck BJ, Kim BS, Kang HY, Reynolds KA, Sherman DH. Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae. Chemistry & Biology. 9: 203-14. PMID 11880035 DOI: 10.1016/S1074-5521(02)00095-9  0.433
2001 Cropp A, Chen S, Liu H, Zhang W, Reynolds KA. Genetic approaches for controlling ratios of related polyketide products in fermentation processes. Journal of Industrial Microbiology & Biotechnology. 27: 368-77. PMID 11774002 DOI: 10.1038/Sj.Jim.7000206  0.759
2001 Smirnova N, Reynolds KA. Branched-chain fatty acid biosynthesis in Escherichia coli Journal of Industrial Microbiology and Biotechnology. 27: 246-251. PMID 11687938 DOI: 10.1038/Sj.Jim.7000185  0.417
2001 Lobo S, Florova G, Reynolds KA. A Streptomyces collinus thiolase with novel acetyl-CoA:acyl carrier protein transacylase activity Biochemistry. 40: 11955-11964. PMID 11570897 DOI: 10.1021/Bi011325A  0.403
2001 Wilson DJ, Xue Y, Reynolds KA, Sherman DH. Characterization and analysis of the PikD regulatory factor in the pikromycin biosynthetic pathway of Streptomyces venezuelae. Journal of Bacteriology. 183: 3468-75. PMID 11344155 DOI: 10.1128/Jb.183.11.3468-3475.2001  0.405
2001 Scarsdale JN, Kazanina G, He X, Reynolds KA, Wright HT. Crystal Structure of the Mycobacterium tuberculosis β-Ketoacyl-Acyl Carrier Protein Synthase III Journal of Biological Chemistry. 276: 20516-20522. PMID 11278743 DOI: 10.1074/Jbc.M010762200  0.48
2001 Smirnova N, Reynolds KA. Engineered fatty acid biosynthesis in Streptomyces by altered catalytic function of β-ketoacyl-acyl carrier protein synthase III Journal of Bacteriology. 183: 2335-2342. PMID 11244075 DOI: 10.1128/Jb.183.7.2335-2342.2001  0.474
2001 Chen S, Roberts JB, Xue Y, Sherman DH, Reynolds KA. The Streptomyces venezuelae pikAV gene contains a transcription unit essential for expression of enzymes involved in glycosylation of narbonolide and 10-deoxymethynolide. Gene. 263: 255-64. PMID 11223265 DOI: 10.1016/S0378-1119(00)00560-6  0.498
2001 Zhang W, Reynolds KA. MeaA, a putative coenzyme B12-dependent mutase, provides methylmalonyl coenzyme A for monensin biosynthesis in Streptomyces cinnamonensis Journal of Bacteriology. 183: 2071-2080. PMID 11222607 DOI: 10.1128/Jb.183.6.2071-2080.2001  0.422
2001 Liu H, Reynolds KA. Precursor supply for polyketide biosynthesis: The role of crotonyl-CoA reductase Metabolic Engineering. 3: 40-48. PMID 11162231 DOI: 10.1006/Mben.2000.0169  0.452
2000 Chen S, Xue Y, Sherman DH, Reynolds KA. Mechanisms of molecular recognition in the pikromycin polyketide synthase. Chemistry & Biology. 7: 907-18. PMID 11137814 DOI: 10.1016/S1074-5521(00)00039-9  0.391
2000 Cropp TA, Wilson DJ, Reynolds KA. Identification of a cyclohexylcarbonyl CoA biosynthetic gene cluster and application in the production of doramectin. Nature Biotechnology. 18: 980-3. PMID 10973220 DOI: 10.1038/79479  0.444
2000 Cropp TA, Smogowicz AA, Hafner EW, Denoya CD, McArthur HA, Reynolds KA. Fatty-acid biosynthesis in a branched-chain alpha-keto acid dehydrogenase mutant of Streptomyces avermitilis. Canadian Journal of Microbiology. 46: 506-14. PMID 10913971  0.306
2000 He X, Mueller JP, Reynolds KA. Development of a scintillation proximity assay for β-ketoacyl-acyl carrier protein synthase iii Analytical Biochemistry. 282: 107-114. PMID 10860506 DOI: 10.1006/Abio.2000.4594  0.409
2000 Patton SM, Cropp TA, Reynolds KA. A novel delta(3),delta(2)-enoyl-CoA isomerase involved in the biosynthesis of the cyclohexanecarboxylic acid-derived moiety of the polyketide ansatrienin A. Biochemistry. 39: 7595-604. PMID 10858310 DOI: 10.1021/Bi0005714  0.466
1999 Liu H, Reynolds KA. Role of crotonyl coenzyme A reductase in determining the ratio of polyketides monensin A and monensin B produced by Streptomyces cinnamonensis Journal of Bacteriology. 181: 6806-6813. PMID 10542184 DOI: 10.1128/Jb.181.21.6806-6813.1999  0.401
1999 Zhang YX, Denoya CD, Skinner DD, Fedechko RW, McArthur HA, Morgenstern MR, Davies RA, Lobo S, Reynolds KA, Hutchinson CR. Genes encoding acyl-CoA dehydrogenase (AcdH) homologues from Streptomyces coelicolor and Streptomyces avermitilis provide insights into the metabolism of small branched-chain fatty acids and macrolide antibiotic production. Microbiology (Reading, England). 145: 2323-34. PMID 10517585 DOI: 10.1099/00221287-145-9-2323  0.479
1999 Zhou P, Florova G, Reynolds KA. Polyketide synthase acyl carrier protein (ACP) as a substrate and a catalyst for malonyl ACP biosynthesis Chemistry and Biology. 6: 577-584. PMID 10421763 DOI: 10.1016/S1074-5521(99)80090-8  0.437
1999 Chen S, von Bamberg D, Hale V, Breuer M, Hardt B, Müller R, Floss HG, Reynolds KA, Leistner E. Biosynthesis of ansatrienin (mycotrienin) and naphthomycin. Identification and analysis of two separate biosynthetic gene clusters in Streptomyces collinus Tü 1892. European Journal of Biochemistry / Febs. 261: 98-107. PMID 10103039 DOI: 10.1046/J.1432-1327.1999.00244.X  0.488
1998 Reynolds KA. Combinatorial biosynthesis: Lesson learned from nature Proceedings of the National Academy of Sciences of the United States of America. 95: 12744-12746. PMID 9788982 DOI: 10.1073/Pnas.95.22.12744  0.386
1998 Han L, Lobo S, Reynolds KA. Characterization of β-ketoacyl-acyl carrier protein synthase III from Streptomyces glaucescens and its role in initiation of fatty acid biosynthesis Journal of Bacteriology. 180: 4481-4486. PMID 9721286 DOI: 10.1128/Jb.180.17.4481-4486.1998  0.487
1998 Stassi DL, Kakavas SJ, Reynolds KA, Gunawardana G, Swanson S, Zeidner D, Jackson M, Liu H, Buko A, Katz L. Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering Proceedings of the National Academy of Sciences of the United States of America. 95: 7305-7309. PMID 9636144 DOI: 10.1073/Pnas.95.13.7305  0.414
1998 Florova G, Denoya CD, Morgenstern MR, Skinner DD, Reynolds KA. Cloning, expression, and characterization of a type II 3-dehydroquinate dehydratase gene from Streptomyces hygroscopicus Archives of Biochemistry and Biophysics. 350: 298-306. PMID 9473305 DOI: 10.1006/Abbi.1997.0536  0.396
1998 Wilson DJ, Patton S, Florova G, Hale V, Reynolds KA. The shikimic acid pathway and polyketide biosynthesis Journal of Industrial Microbiology and Biotechnology. 20: 299-303. DOI: 10.1038/Sj.Jim.2900527  0.417
1998 Florova G, Lindsay YM, Brown MS, McArthur HAI, Denoya CD, Reynolds KA. Stereochemical analyses of the Streptomyces hygroscopicus var. ascomyceticus Type-II dehydroquinate dehydratase and evidence for a role of the enzyme in the biosynthesis of the shikimate-derived moiety of ascomycin Journal of Organic Chemistry. 63: 8098-8099. DOI: 10.1021/Jo981712Z  0.372
1997 Reynolds KA, Wallace KK, Handa S, Brown MS, McArthur HA, Floss HG. Biosynthesis of the shikimate-derived starter unit of the immunosuppressant ascomycin: stereochemistry of the 1,4-conjugate elimination. The Journal of Antibiotics. 50: 701-3. PMID 9315087 DOI: 10.7164/Antibiotics.50.701  0.307
1997 Han L, Reynolds KA. A novel alternate anaplerotic pathway to the glyoxylate cycle in streptomycetes Journal of Bacteriology. 179: 5157-5164. PMID 9260959 DOI: 10.1128/Jb.179.16.5157-5164.1997  0.457
1997 Wallace KK, Lobo S, Han L, McArthur HAI, Reynolds KA. In vivo and in vitro effects of thiolactomycin on fatty acid biosynthesis in Streptomyces collinus Journal of Bacteriology. 179: 3884-3891. PMID 9190803 DOI: 10.1128/Jb.179.12.3884-3891.1997  0.434
1997 Liu H, Wallace KK, Reynolds KA. Linking diversity in evolutionary origin and stereospecificity for enoyl thioester reductases: Determination and interpretation of the novel stereochemical course of reaction catalyzed by crotonyl CoA reductase from Streptomyces collinus Journal of the American Chemical Society. 119: 2973-2979. DOI: 10.1021/Ja961047G  0.399
1996 Wang P, Denoya CD, Morgenstern MR, Skinner DD, Wallace KK, Digate R, Patton S, Banavali N, Schuler G, Speedie MK, Reynolds KA. Cloning and characterization of the gene encoding 1- cyclohexenylcarbonyl coenzyme A reductase from Streptomyces collinus Journal of Bacteriology. 178: 6873-6881. PMID 8955309 DOI: 10.1128/Jb.178.23.6873-6881.1996  0.463
1995 O'Hagan D, Rogers SV, Duffin GR, Reynolds KA. The biosynthesis of monensin-A: Thymine, β-aminoisobutyrate and methacrylate metabolism in Streptomyces cinnamonensis Journal of Antibiotics. 48: 1280-1287. PMID 8557569 DOI: 10.7164/Antibiotics.48.1280  0.344
1995 Wallace KK, Bao ZY, Dai H, Digate R, Schuler G, Speedie MK, Reynolds KA. Purification of crotonyl-CoA reductase from Streptomyces collinus and cloning, sequencing and expression of the corresponding gene in Escherichia coli European Journal of Biochemistry. 233: 954-962. PMID 8521864 DOI: 10.1111/J.1432-1033.1995.954_3.X  0.468
1995 Wallace KK, Zhao B, McArthur HAI, Reynolds KA. In vivo analysis of straight-chain and branched-chain fatty acid biosynthesis in three actinomycetes Fems Microbiology Letters. 131: 227-234. PMID 7557334 DOI: 10.1111/J.1574-6968.1995.Tb07781.X  0.384
1995 Bridge CF, O'Hagan D, Reynolds KA, Wallace KK. Kinetic and stereoelectronic effects of a fluorine substituent on the reaction catalysed by an NADPH-dependent cyclohex-1-enylcarbonyl CoA reductase Journal of the Chemical Society, Chemical Communications. 2329-2330. DOI: 10.1039/C39950002329  0.411
1994 Wallace KK, Reynolds KA, Koch K, McArthur HAI, Brown MS, Wax RG, Moore BS. Biosynthetic studies of ascomycin (FK520): formation of the (1R,3R,4R)-3,4-dihydroxycyclohexanecarboxylic acid-derived moiety Journal of the American Chemical Society. 116: 11600-11601. DOI: 10.1021/Ja00104A063  0.476
1993 Reynolds KA, Seaton N, Fox KM, Warner K, Wang P. Mechanistic studies of a Δ1,Δ2-cyclohexenylcarbonyl CoA isomerase catalyzing the penultimate step in the biosynthesis of the cyclohexanecarboxylic acid moiety of ansatrienin A Journal of Natural Products. 56: 825-829. DOI: 10.1021/Np50096A004  0.422
1993 Reynolds KA. Comparison of two unusual enoyl-CoA reductases in Streptomyces collinus Journal of Natural Products. 56: 175-185. DOI: 10.1021/Np50092A002  0.495
1993 Moore BS, Cho H, Casati R, Kennedy E, Reynolds KA, Mocek U, Beale JM, Floss HG. Biosynthetic studies on ansatrienin A. Formation of the cyclohexanecarboxylic acid moiety. [Erratum to document cited in CA119(9):90959x] Journal of the American Chemical Society. 115: 11656-11656. DOI: 10.1021/Ja00077A100  0.498
1993 Moore BS, Cho H, Casati R, Kennedy E, Reynolds KA, Mocek U, Beale JM, Floss HG. Biosynthetic studies on ansatrienin A. Formation of the cyclohexanecarboxylic acid moiety Journal of the American Chemical Society. 115: 5254-5266. DOI: 10.1021/ja00065a042  0.515
1993 Moore BS, Cho H, Casati R, Kennedy E, Reynolds KA, Mocek U, Beale JM, Floss HG. Biosynthetic studies on ansatrienin A. Formation of the cyclohexanecarboxylic acid moiety Journal of the American Chemical Society. 115: 5254-5266. DOI: 10.1021/Ja00065A042  0.529
1992 Reynolds KA, Wang P, Fox KM, Speedie MK, Lam Y, Floss HG. Purification and characterization of a novel enoyl coenzyme A reductase from Streptomyces collinus. Journal of Bacteriology. 174: 3850-4. PMID 1597409 DOI: 10.1128/Jb.174.12.3850-3854.1992  0.47
1992 Callery PS, Subramanyam B, Yuan ZM, Pou S, Geelhaar LA, Reynolds KA. Isotopically sensitive regioselectivity in the oxidative deamination of a homologous series of diamines catalyzed by diamine oxidase Chemico-Biological Interactions. 85: 15-26. PMID 1458548 DOI: 10.1016/0009-2797(92)90049-Q  0.358
1991 Reynolds KA, Fox KM, Yuan Z, Lam Y. Biosynthesis of ansatrienin: Stereochemical course of the final reduction step leading to the cyclohexanecarboxylic acid moiety Journal of the American Chemical Society. 113: 4339-4340. DOI: 10.1021/Ja00011A051  0.394
1988 Reynolds KA, O'Hagan D, Gani D, Robinson JA. Butyrate metabolism in streptomycetes. Characterization of an intramolecular vicinal interchange rearrangement linking isobutyrate and butyrate in Streptomyces cinnamonensis Journal of the Chemical Society, Perkin Transactions 1. 3195-3207. DOI: 10.1039/P19880003195  0.511
1988 Brendelberger G, Rétey J, Ashworth DM, Reynolds K, Willenbrock F, Robinson JA. The Enzymic Interconversion of Isobutyryl andn-Butyrylcarba(dethia)-Coenzyme A: A Coenzyme-B12-dependent Carbon Skeleton Rearrangement Angewandte Chemie International Edition in English. 27: 1089-1090. DOI: 10.1002/Anie.198810891  0.648
1988 Brendelberger G, Rétey J, Ashworth DM, Reynolds K, Willenbrock F, Robinson JA. Die enzymatische Umwandlung von Isobutyryl- zun-Butyrylcarba(dethia)-Coenzym A: Eine coenzym-B12-abhängige Gerüstumlagerung Angewandte Chemie. 100: 1122-1124. DOI: 10.1002/Ange.19881000825  0.591
1986 Reynolds K, Gani D, Robinson JA. Biosynthesis of monensin. Evidence for a vicinal interchange rearrangement linking n-butyryl-CoA and isobutyryl-CoA Journal of the Chemical Society, Chemical Communications. 1334-1336. DOI: 10.1039/C39860001334  0.482
1985 Gani D, O'Hagan D, Reynolds K, Robinson JA. Biosynthesis of the polyether antibiotic monensin-A: Stereochemical aspects of the incorporation and metabolism of isobutyrate Journal of the Chemical Society, Chemical Communications. 1002-1004. DOI: 10.1039/C39850001002  0.491
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