Joshua W. Knowles, Ph.D. - Publications

Affiliations: 
2001 University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Genetics, Molecular Biology, Animal Physiology Biology

53 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Parizo J, Sarraju A, Knowles JW. Novel Therapies for Familial Hypercholesterolemia. Current Treatment Options in Cardiovascular Medicine. 18: 64. PMID 27620638 DOI: 10.1007/s11936-016-0486-2  0.96
2016 Priest JR, Knowles JW. Standards of Evidence and Mechanistic Inference in Autosomal Recessive Hypercholesterolemia. Arteriosclerosis, Thrombosis, and Vascular Biology. 36: 1465-6. PMID 27466618 DOI: 10.1161/ATVBAHA.116.307714  0.96
2016 Knowles JW. Statins in Familial Hypercholesterolemia: Translating Evidence to Action. Journal of the American College of Cardiology. 68: 261-4. PMID 27417003 DOI: 10.1016/j.jacc.2016.05.024  0.96
2016 Rodriguez F, Knowles JW. Enough Evidence, Time to Act! Circulation. 134: 20-3. PMID 27358433 DOI: 10.1161/CIRCULATIONAHA.116.023010  0.96
2016 Caleshu C, Kasparian NA, Edwards KS, Yeates L, Semsarian C, Perez M, Ashley E, Turner CJ, Knowles JW, Ingles J. Interdisciplinary psychosocial care for families with inherited cardiovascular diseases. Trends in Cardiovascular Medicine. PMID 27256036 DOI: 10.1016/j.tcm.2016.04.010  0.96
2016 deGoma EM, Ahmad ZS, O'Brien EC, Kindt I, Shrader P, Newman CB, Pokharel Y, Baum SJ, Hemphill LC, Hudgins LC, Ahmed CD, Gidding SS, Duffy D, Neal W, Wilemon K, ... ... Knowles JW, et al. Treatment Gaps in Adults with Heterozygous Familial Hypercholesterolemia in the United States: Data from the CASCADE-FH Registry. Circulation. Cardiovascular Genetics. PMID 27013694 DOI: 10.1161/CIRCGENETICS.116.001381  0.96
2016 Finocchiaro G, Haddad F, Kobayashi Y, Lee D, Pavlovic A, Schnittger I, Sinagra G, Magavern E, Myers J, Froelicher V, Knowles JW, Ashley E. Impact of Septal Reduction on Left Atrial Size and Diastole in Hypertrophic Cardiomyopathy. Echocardiography (Mount Kisco, N.Y.). PMID 26926154 DOI: 10.1111/echo.13158  0.96
2016 Sarraju A, Kim SH, Knowles JW. Cardiometabolic Effects of Glucagon-Like Peptide-1 Agonists. Current Atherosclerosis Reports. 18: 7. PMID 26782825 DOI: 10.1007/s11883-016-0558-5  0.96
2015 Gidding SS, Ann Champagne M, de Ferranti SD, Defesche J, Ito MK, Knowles JW, McCrindle B, Raal F, Rader D, Santos RD, Lopes-Virella M, Watts GF, Wierzbicki AS. The Agenda for Familial Hypercholesterolemia: A Scientific Statement From the American Heart Association. Circulation. PMID 26510694 DOI: 10.1161/CIR.0000000000000297  0.96
2015 Priest JR, Yang W, Reaven G, Knowles JW, Shaw GM. Maternal Midpregnancy Glucose Levels and Risk of Congenital Heart Disease in Offspring. Jama Pediatrics. 1-5. PMID 26457543 DOI: 10.1001/jamapediatrics.2015.2831  0.96
2015 Goldstein BA, Knowles JW, Salfati E, Ioannidis JP, Assimes TL. Corrigendum: Simple, standardized incorporation of genetic risk into non-genetic risk prediction tools for complex traits: coronary heart disease as an example. Frontiers in Genetics. 6: 231. PMID 26217377 DOI: 10.3389/fgene.2015.00231  0.96
2015 Bent RE, Wheeler MT, Hadley D, Knowles JW, Pavlovic A, Finocchiaro G, Haddad F, Salisbury H, Race S, Shmargad Y, Matheson GO, Kumar N, Saini D, Froelicher V, Ashley E, et al. Systematic Comparison of Digital Electrocardiograms From Healthy Athletes and Patients With Hypertrophic Cardiomyopathy. Journal of the American College of Cardiology. 65: 2462-3. PMID 26046742 DOI: 10.1016/j.jacc.2015.03.559  0.96
2015 Fall T, Xie W, Poon W, Yaghootkar H, Mägi R, Knowles JW, Lyssenko V, Weedon M, Frayling TM, Ingelsson E. Using Genetic Variants to Assess the Relationship Between Circulating Lipids and Type 2 Diabetes. Diabetes. 64: 2676-84. PMID 25948681 DOI: 10.2337/db14-1710  0.96
2015 Finocchiaro G, Haddad F, Knowles JW, Caleshu C, Pavlovic A, Homburger J, Shmargad Y, Sinagra G, Magavern E, Wong M, Perez M, Schnittger I, Myers J, Froelicher V, Ashley EA. Cardiopulmonary responses and prognosis in hypertrophic cardiomyopathy: a potential role for comprehensive noninvasive hemodynamic assessment. Jacc. Heart Failure. 3: 408-18. PMID 25863972 DOI: 10.1016/j.jchf.2014.11.011  0.96
2015 Knowles JW, Xie W, Zhang Z, Chennemsetty I, Assimes TL, Paananen J, Hansson O, Pankow J, Goodarzi MO, Carcamo-Orive I, Morris AP, Chen YD, Mäkinen VP, Ganna A, Mahajan A, et al. Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene. The Journal of Clinical Investigation. 125: 1739-51. PMID 25798622 DOI: 10.1172/JCI74692  0.96
2015 Finocchiaro G, Kobayashi Y, Magavern E, Zhou JQ, Ashley E, Sinagra G, Schnittger I, Knowles JW, Fearon WF, Haddad F, Tremmel JA. Prevalence and prognostic role of right ventricular involvement in stress-induced cardiomyopathy. Journal of Cardiac Failure. 21: 419-25. PMID 25704104 DOI: 10.1016/j.cardfail.2015.02.001  0.96
2014 Yaghootkar H, Scott RA, White CC, Zhang W, Speliotes E, Munroe PB, Ehret GB, Bis JC, Fox CS, Walker M, Borecki IB, Knowles JW, Yerges-Armstrong L, Ohlsson C, Perry JR, et al. Genetic evidence for a normal-weight "metabolically obese" phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes. Diabetes. 63: 4369-77. PMID 25048195 DOI: 10.2337/db14-0318  0.96
2014 Finocchiaro G, Haddad F, Pavlovic A, Magavern E, Sinagra G, Knowles JW, Myers J, Ashley EA. How does morphology impact on diastolic function in hypertrophic cardiomyopathy? A single centre experience. Bmj Open. 4: e004814. PMID 24928584 DOI: 10.1136/bmjopen-2014-004814  0.96
2014 O'Brien EC, Roe MT, Fraulo ES, Peterson ED, Ballantyne CM, Genest J, Gidding SS, Hammond E, Hemphill LC, Hudgins LC, Kindt I, Moriarty PM, Ross J, Underberg JA, Watson K, ... ... Knowles JW, et al. Rationale and design of the familial hypercholesterolemia foundation CAscade SCreening for Awareness and DEtection of Familial Hypercholesterolemia registry. American Heart Journal. 167: 342-349.e17. PMID 24576518 DOI: 10.1016/j.ahj.2013.12.008  0.96
2014 Finocchiaro G, Haddad F, Pavlovic A, Sinagra G, Schnittger I, Knowles JW, Perez M, Magavern E, Myers J, Ashley E. Latent obstruction and left atrial size are predictors of clinical deterioration leading to septal reduction in hypertrophic cardiomyopathy. Journal of Cardiac Failure. 20: 236-43. PMID 24486928 DOI: 10.1016/j.cardfail.2014.01.014  0.96
2014 Finocchiaro G, Murphy D, Pavlovic A, Haddad F, Shiran H, Sinagra G, Ashley EA, Knowles JW. Unexplained double-chambered left ventricle associated with contracting right ventricular aneurysm and right atrial enlargement. Echocardiography (Mount Kisco, N.Y.). 31: E80-4. PMID 24299065 DOI: 10.1111/echo.12467  0.96
2014 Dimas AS, Lagou V, Barker A, Knowles JW, Mägi R, Hivert MF, Benazzo A, Rybin D, Jackson AU, Stringham HM, Song C, Fischer-Rosinsky A, Boesgaard TW, Grarup N, Abbasi FA, et al. Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity. Diabetes. 63: 2158-71. PMID 24296717 DOI: 10.2337/db13-0949  0.96
2014 Finocchiaro G, Knowles JW, Pavlovic A, Perez M, Magavern E, Sinagra G, Haddad F, Ashley EA. Prevalence and clinical correlates of right ventricular dysfunction in patients with hypertrophic cardiomyopathy. The American Journal of Cardiology. 113: 361-7. PMID 24230980 DOI: 10.1016/j.amjcard.2013.09.045  0.96
2013 Heidenreich PA, Lin S, Knowles JW, Perez M, Maddox TM, Ho MP, Rumsfeld JS, Sahay A, Massie BM, Tsai TT, Witteles RM. Variation in use of left ventriculography in the Veterans Affairs Health Care System. Circulation. Cardiovascular Quality and Outcomes. 6: 687-93. PMID 24192569 DOI: 10.1161/CIRCOUTCOMES.113.000199  0.96
2013 Kuo JZ, Sheu WH, Assimes TL, Hung YJ, Absher D, Chiu YF, Mak J, Wang JS, Kwon S, Hsu CC, Goodarzi MO, Lee IT, Knowles JW, Miller BE, Lee WJ, et al. Trans-ethnic fine mapping identifies a novel independent locus at the 3' end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population. Diabetologia. 56: 2619-28. PMID 24013783 DOI: 10.1007/s00125-013-3047-1  0.96
2013 Yaghootkar H, Lamina C, Scott RA, Dastani Z, Hivert MF, Warren LL, Stancáková A, Buxbaum SG, Lyytikäinen LP, Henneman P, Wu Y, Cheung CY, Pankow JS, Jackson AU, Gustafsson S, ... ... Knowles JW, et al. Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes. Diabetes. 62: 3589-98. PMID 23835345 DOI: 10.2337/db13-0128  0.96
2013 Hammond E, Watts GF, Rubinstein Y, Farid W, Livingston M, Knowles JW, Lochmüller H, Bellgard M, Dawkins HJ. Role of international registries in enhancing the care of familial hypercholesterolaemia. International Journal of Evidence-Based Healthcare. 11: 134-9. PMID 23750577 DOI: 10.1111/1744-1609.12023  0.96
2013 Coram MA, Duan Q, Hoffmann TJ, Thornton T, Knowles JW, Johnson NA, Ochs-Balcom HM, Donlon TA, Martin LW, Eaton CB, Robinson JG, Risch NJ, Zhu X, Kooperberg C, Li Y, et al. Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations. American Journal of Human Genetics. 92: 904-16. PMID 23726366 DOI: 10.1016/j.ajhg.2013.04.025  0.96
2013 Liang P, Lan F, Lee AS, Gong T, Sanchez-Freire V, Wang Y, Diecke S, Sallam K, Knowles JW, Wang PJ, Nguyen PK, Bers DM, Robbins RC, Wu JC. Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity. Circulation. 127: 1677-91. PMID 23519760 DOI: 10.1161/CIRCULATIONAHA.113.001883  0.96
2013 Xie W, Wood AR, Lyssenko V, Weedon MN, Knowles JW, Alkayyali S, Assimes TL, Quertermous T, Abbasi F, Paananen J, Häring H, Hansen T, Pedersen O, Smith U, Laakso M, et al. Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes. Diabetes. 62: 2141-50. PMID 23378610 DOI: 10.2337/db12-0876  0.96
2013 Deloukas P, Kanoni S, Willenborg C, Farrall M, Assimes TL, Thompson JR, Ingelsson E, Saleheen D, Erdmann J, Goldstein BA, Stirrups K, König IR, Cazier JB, Johansson A, ... ... Knowles JW, et al. Large-scale association analysis identifies new risk loci for coronary artery disease. Nature Genetics. 45: 25-33. PMID 23202125 DOI: 10.1038/ng.2480  0.96
2012 Knowles JW, Assimes TL, Kiernan M, Pavlovic A, Goldstein BA, Yank V, McConnell MV, Absher D, Bustamante C, Ashley EA, Ioannidis JP. Randomized trial of personal genomics for preventive cardiology: design and challenges. Circulation. Cardiovascular Genetics. 5: 368-76. PMID 22715281 DOI: 10.1161/CIRCGENETICS.112.962746  0.96
2011 Kraja AT, Vaidya D, Pankow JS, Goodarzi MO, Assimes TL, Kullo IJ, Sovio U, Mathias RA, Sun YV, Franceschini N, Absher D, Li G, Zhang Q, Feitosa MF, Glazer NL, ... ... Knowles JW, et al. A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. Diabetes. 60: 1329-39. PMID 21386085 DOI: 10.2337/db10-1011  0.96
2011 Schunkert H, König IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, Preuss M, Stewart AF, Barbalic M, Gieger C, Absher D, Aherrahrou Z, Allayee H, Altshuler D, Anand SS, ... ... Knowles JW, et al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nature Genetics. 43: 333-8. PMID 21378990 DOI: 10.1038/ng.784  0.96
2010 Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, Thorleifsson G, Zillikens MC, Speliotes EK, Mägi R, Workalemahu T, White CC, Bouatia-Naji N, Harris TB, Berndt SI, ... ... Knowles JW, et al. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nature Genetics. 42: 949-60. PMID 20935629 DOI: 10.1038/ng.685  0.96
2010 Assimes TL, Hólm H, Kathiresan S, Reilly MP, Thorleifsson G, Voight BF, Erdmann J, Willenborg C, Vaidya D, Xie C, Patterson CC, Morgan TM, Burnett MS, Li M, Hlatky MA, ... Knowles JW, et al. Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. Journal of the American College of Cardiology. 56: 1552-63. PMID 20933357 DOI: 10.1016/j.jacc.2010.06.022  0.96
2010 Lango Allen H, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F, Willer CJ, Jackson AU, Vedantam S, Raychaudhuri S, Ferreira T, Wood AR, Weyant RJ, Segrè AV, Speliotes EK, ... ... Knowles JW, et al. Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature. 467: 832-8. PMID 20881960 DOI: 10.1038/nature09410  0.96
2010 Ingelsson E, Langenberg C, Hivert MF, Prokopenko I, Lyssenko V, Dupuis J, Mägi R, Sharp S, Jackson AU, Assimes TL, Shrader P, Knowles JW, Zethelius B, Abbasi FA, Bergman RN, et al. Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans. Diabetes. 59: 1266-75. PMID 20185807 DOI: 10.2337/db09-1568  0.96
2009 Zakharia F, Basu A, Absher D, Assimes TL, Go AS, Hlatky MA, Iribarren C, Knowles JW, Li J, Narasimhan B, Sidney S, Southwick A, Myers RM, Quertermous T, Risch N, et al. Characterizing the admixed African ancestry of African Americans. Genome Biology. 10: R141. PMID 20025784 DOI: 10.1186/gb-2009-10-12-r141  0.96
2008 Assimes TL, Knowles JW, Basu A, Iribarren C, Southwick A, Tang H, Absher D, Li J, Fair JM, Rubin GD, Sidney S, Fortmann SP, Go AS, Hlatky MA, Myers RM, et al. Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE study. Human Molecular Genetics. 17: 2320-8. PMID 18443000 DOI: 10.1093/hmg/ddn132  0.96
2008 Knowles JW, Assimes TL, Boerwinkle E, Fortmann SP, Go A, Grove ML, Hlatky M, Iribarren C, Li J, Myers R, Risch N, Sidney S, Southwick A, Volcik KA, Quertermous T. Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD. Bmc Medical Genetics. 9: 23. PMID 18384690 DOI: 10.1186/1471-2350-9-23  0.96
2008 Assimes TL, Knowles JW, Priest JR, Basu A, Volcik KA, Southwick A, Tabor HK, Hartiala J, Allayee H, Grove ML, Tabibiazar R, Sidney S, Fortmann SP, Go A, Hlatky M, et al. Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease. Human Genetics. 123: 399-408. PMID 18369664 DOI: 10.1007/s00439-008-0489-5  0.96
2008 Assimes TL, Knowles JW, Priest JR, Basu A, Borchert A, Volcik KA, Grove ML, Tabor HK, Southwick A, Tabibiazar R, Sidney S, Boerwinkle E, Go AS, Iribarren C, Hlatky MA, et al. A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease. Atherosclerosis. 198: 136-44. PMID 17959182 DOI: 10.1016/j.atherosclerosis.2007.09.003  0.96
2007 Knowles JW, Wang H, Itakura H, Southwick A, Myers RM, Iribarren C, Fortmann SP, Go AS, Quertermous T, Hlatky MA. Association of polymorphisms in platelet and hemostasis system genes with acute myocardial infarction. American Heart Journal. 154: 1052-8. PMID 18035074 DOI: 10.1016/j.ahj.2007.05.021  0.96
2007 Knowles JW, Assimes TL, Li J, Quertermous T, Cooke JP. Genetic susceptibility to peripheral arterial disease: a dark corner in vascular biology. Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 2068-78. PMID 17656669 DOI: 10.1161/01.ATV.0000282199.66398.8c  0.96
2003 Alexander MR, Knowles JW, Nishikimi T, Maeda N. Increased atherosclerosis and smooth muscle cell hypertrophy in natriuretic peptide receptor A-/-apolipoprotein E-/- mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 23: 1077-82. PMID 12702516 DOI: 10.1161/01.ATV.0000071702.45741.2E  0.96
2003 Knowles JW, Erickson LM, Guy VK, Sigel CS, Wilder JC, Maeda N. Common variations in noncoding regions of the human natriuretic peptide receptor A gene have quantitative effects. Human Genetics. 112: 62-70. PMID 12483301 DOI: 10.1007/s00439-002-0834-z  0.96
2002 Ellmers LJ, Knowles JW, Kim HS, Smithies O, Maeda N, Cameron VA. Ventricular expression of natriuretic peptides in Npr1(-/-) mice with cardiac hypertrophy and fibrosis. American Journal of Physiology. Heart and Circulatory Physiology. 283: H707-14. PMID 12124219 DOI: 10.1152/ajpheart.00677.2001  0.96
2002 Hodgin JB, Knowles JW, Kim HS, Smithies O, Maeda N. Interactions between endothelial nitric oxide synthase and sex hormones in vascular protection in mice. The Journal of Clinical Investigation. 109: 541-8. PMID 11854327 DOI: 10.1172/JCI14066  0.96
2001 Goy MF, Oliver PM, Purdy KE, Knowles JW, Fox JE, Mohler PJ, Qian X, Smithies O, Maeda N. Evidence for a novel natriuretic peptide receptor that prefers brain natriuretic peptide over atrial natriuretic peptide. The Biochemical Journal. 358: 379-87. PMID 11513736 DOI: 10.1042/0264-6021:3580379  0.96
2001 Knowles JW, Esposito G, Mao L, Hagaman JR, Fox JE, Smithies O, Rockman HA, Maeda N. Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice. The Journal of Clinical Investigation. 107: 975-84. PMID 11306601 DOI: 10.1172/JCI11273  0.96
2000 Knowles JW, Maeda N. Genetic modifiers of atherosclerosis in mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 20: 2336-45. PMID 11073835  0.96
2000 Knowles JW, Reddick RL, Jennette JC, Shesely EG, Smithies O, Maeda N. Enhanced atherosclerosis and kidney dysfunction in eNOS(-/-)Apoe(-/-) mice are ameliorated by enalapril treatment. The Journal of Clinical Investigation. 105: 451-8. PMID 10683374 DOI: 10.1172/JCI8376  0.96
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