Raymond J. Hohl - Publications

Affiliations: 
Molecular & Cell Biology University of Iowa, Iowa City, IA 
Area:
Molecular Biology, Biochemistry

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Year Citation  Score
2022 Koubek EJ, Weissenrieder JS, Ortiz LE, Nwogu N, Pham AM, Weissenkampen JD, Reed JL, Neighbors JD, Hohl RJ, Kwun HJ. Therapeutic Potential of 5'-Methylschweinfurthin G in Merkel Cell Polyomavirus-Positive Merkel Cell Carcinoma. Viruses. 14. PMID 36146655 DOI: 10.3390/v14091848  0.303
2019 Larson-Casey JL, Vaid M, Gu L, He C, Cai GQ, Ding Q, Davis D, Berryhill TF, Wilson LS, Barnes S, Neighbors JD, Hohl RJ, Zimmerman KA, Yoder BK, Longhini ALF, et al. Increased flux through the mevalonate pathway mediates fibrotic repair without injury. The Journal of Clinical Investigation. PMID 31609245 DOI: 10.1172/Jci127959  0.302
2019 Kokolus KM, Haley JS, Koubek EJ, Gowda R, Dinavahi SS, Sharma A, Claxton DF, Helm KF, Drabick JJ, Robertson GP, Neighbors JD, Hohl RJ, Schell TD. Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity. Oncoimmunology. 8: e1539614. PMID 30713799 DOI: 10.1080/2162402X.2018.1539614  0.316
2018 Koubek EJ, Weissenrieder JS, Neighbors JD, Hohl RJ. Schweinfurthins: Lipid Modulators with Promising Anticancer Activity. Lipids. PMID 30334267 DOI: 10.1002/Lipd.12088  0.408
2018 Wang L, Jia B, Claxton DF, Ehmann WC, Rybka WB, Mineishi S, Naik S, Khawaja MR, Sivik J, Han J, Hohl RJ, Zheng H. VISTA is highly expressed on MDSCs and mediates an inhibition of T cell response in patients with AML. Oncoimmunology. 7: e1469594. PMID 30228937 DOI: 10.1080/2162402X.2018.1469594  0.353
2018 Weissenrieder JS, Reilly JE, Neighbors JD, Hohl RJ. Inhibiting geranylgeranyl diphosphate synthesis reduces nuclear androgen receptor signaling and neuroendocrine differentiation in prostate cancer cell models. The Prostate. PMID 30106164 DOI: 10.1002/Pros.23707  0.688
2018 Jia B, Zhao C, Claxton DF, Ehmann WC, Rybka WB, Mineishi S, Naik S, Songdej N, Khawaja M, Hohl RJ, Zheng H. TIGIT Expression Positively Associates with NK Cell Function in AML Patients Blood. 132: 5250-5250. DOI: 10.1182/Blood-2018-99-113578  0.328
2017 Zhu L, Kong Y, Zhang J, Claxton DF, Ehmann WC, Rybka WB, Palmisiano ND, Wang M, Jia B, Bayerl M, Schell TD, Hohl RJ, Zeng H, Zheng H. Blimp-1 impairs T cell function via upregulation of TIGIT and PD-1 in patients with acute myeloid leukemia. Journal of Hematology & Oncology. 10: 124. PMID 28629373 DOI: 10.1186/S13045-017-0486-Z  0.304
2017 Schoenfeld JD, Sibenaller ZA, Mapuskar KA, Wagner BA, Cramer-Morales KL, Furqan M, Sandhu S, Carlisle TL, Smith MC, Abu Hejleh T, Berg DJ, Zhang J, Keech J, Parekh KR, Bhatia S, ... ... Hohl RJ, et al. O2(⋅-) and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate. Cancer Cell. PMID 28366679 DOI: 10.1016/J.Ccell.2017.02.018  0.348
2016 Reilly JE, Neighbors JD, Hohl RJ. Targeting protein geranylgeranylation slows tumor development in a murine model of prostate cancer metastasis. Cancer Biology & Therapy. 0. PMID 27624889 DOI: 10.1080/15384047.2016.1219817  0.697
2015 Kuder CH, Weivoda MM, Zhang Y, Zhu J, Neighbors JD, Wiemer DF, Hohl RJ. 3-Deoxyschweinfurthin B Lowers Cholesterol Levels by Decreasing Synthesis and Increasing Export in Cultured Cancer Cell Lines. Lipids. PMID 26494560 DOI: 10.1007/S11745-015-4083-Z  0.779
2015 Reilly JE, Neighbors JD, Tong H, Henry MD, Hohl RJ. Targeting geranylgeranylation reduces adrenal gland tumor burden in a murine model of prostate cancer metastasis. Clinical & Experimental Metastasis. 32: 555-66. PMID 26070429 DOI: 10.1007/S10585-015-9727-0  0.694
2015 Sheehy RM, Kuder CH, Bachman Z, Hohl RJ. Calcium and P-glycoprotein independent synergism between schweinfurthins and verapamil. Cancer Biology & Therapy. 16: 1259-68. PMID 26046259 DOI: 10.1080/15384047.2015.1056420  0.77
2015 Reilly JE, Zhou X, Tong H, Kuder CH, Wiemer DF, Hohl RJ. In vitro studies in a myelogenous leukemia cell line suggest an organized binding of geranylgeranyl diphosphate synthase inhibitors. Biochemical Pharmacology. 96: 83-92. PMID 25952057 DOI: 10.1016/J.Bcp.2015.04.009  0.789
2014 Zhou X, Reilly JE, Loerch KA, Hohl RJ, Wiemer DF. Synthesis of isoprenoid bisphosphonate ethers through C-P bond formations: Potential inhibitors of geranylgeranyl diphosphate synthase. Beilstein Journal of Organic Chemistry. 10: 1645-50. PMID 25161722 DOI: 10.3762/Bjoc.10.171  0.692
2014 Sheehy RM, Bachman ZC, Hohl RJ. Abstract 811: Schweinfurthin activity enhanced by verapamil Cancer Research. 74: 811-811. DOI: 10.1158/1538-7445.Am2014-811  0.401
2014 Reilly JE, Neighbors JD, Bannick N, Henry MD, Kuder CH, Hohl RJ. Abstract 4032: Targeting the isoprenoid biosynthetic pathway in a murine model of metastatic prostate cancer Cancer Research. 74: 4032-4032. DOI: 10.1158/1538-7445.Am2014-4032  0.769
2013 Tong H, Kuder CH, Wasko BM, Hohl RJ. Quantitative determination of isopentenyl diphosphate in cultured mammalian cells. Analytical Biochemistry. 433: 36-42. PMID 23000003 DOI: 10.1016/J.Ab.2012.09.001  0.771
2013 Bhasin N, Stevens J, Niki M, Tong H, Kuder C, Hohl RJ, Lentz SR. Dissecting The Effects Of Isoprenoid Pathway Inhibition On Hemostasis and Thrombosis: Differential Effects Of Atorvastatin and Digeranyl Bisphosphonate In Hypercholesterolemic Mice Blood. 122: 2378-2378. DOI: 10.1182/Blood.V122.21.2378.2378  0.739
2012 Holstein SA, Hohl RJ. Is there a future for prenyltransferase inhibitors in cancer therapy? Current Opinion in Pharmacology. 12: 704-9. PMID 22817869 DOI: 10.1016/J.Coph.2012.06.013  0.325
2012 Kuder CH, Sheehy RM, Neighbors JD, Wiemer DF, Hohl RJ. Functional evaluation of a fluorescent schweinfurthin: mechanism of cytotoxicity and intracellular quantification. Molecular Pharmacology. 82: 9-16. PMID 22461663 DOI: 10.1124/Mol.111.077107  0.792
2012 Messing E, Gee JR, Saltzstein DR, Kim K, diSant'Agnese A, Kolesar J, Harris L, Faerber A, Havighurst T, Young JM, Efros M, Getzenberg RH, Wheeler MA, Tangrea J, Parnes H, ... ... Hohl R, et al. A phase 2 cancer chemoprevention biomarker trial of isoflavone G-2535 (genistein) in presurgical bladder cancer patients. Cancer Prevention Research (Philadelphia, Pa.). 5: 621-30. PMID 22293631 DOI: 10.1158/1940-6207.Capr-11-0455  0.327
2012 Weivoda MM, Hohl RJ. Geranylgeranyl pyrophosphate stimulates PPARγ expression and adipogenesis through the inhibition of osteoblast differentiation. Bone. 50: 467-76. PMID 22019459 DOI: 10.1016/J.Bone.2011.09.056  0.721
2011 Wiemer AJ, Wiemer DF, Hohl RJ. Geranylgeranyl diphosphate synthase: an emerging therapeutic target. Clinical Pharmacology and Therapeutics. 90: 804-12. PMID 22048229 DOI: 10.1038/Clpt.2011.215  0.647
2011 Wasko BM, Smits JP, Shull LW, Wiemer DF, Hohl RJ. A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro. Journal of Lipid Research. 52: 1957-64. PMID 21903868 DOI: 10.1194/Jlr.M016089  0.443
2011 Witzig TE, Tang H, Micallef IN, Ansell SM, Link BK, Inwards DJ, Porrata LF, Johnston PB, Colgan JP, Markovic SN, Nowakowski GS, Thompson CA, Allmer C, Maurer MJ, Gupta M, ... ... Hohl R, et al. Multi-institutional phase 2 study of the farnesyltransferase inhibitor tipifarnib (R115777) in patients with relapsed and refractory lymphomas. Blood. 118: 4882-9. PMID 21725056 DOI: 10.1182/Blood-2011-02-334904  0.312
2011 Holstein SA, Kuder CH, Tong H, Hohl RJ. Pleiotropic effects of a schweinfurthin on isoprenoid homeostasis. Lipids. 46: 907-21. PMID 21633866 DOI: 10.1007/S11745-011-3572-Y  0.794
2011 Weivoda MM, Hohl RJ. Effects of farnesyl pyrophosphate accumulation on calvarial osteoblast differentiation. Endocrinology. 152: 3113-22. PMID 21586555 DOI: 10.1210/En.2011-0016  0.727
2011 Weivoda MM, Hohl RJ. The effects of direct inhibition of geranylgeranyl pyrophosphate synthase on osteoblast differentiation. Journal of Cellular Biochemistry. 112: 1506-13. PMID 21503955 DOI: 10.1002/Jcb.23087  0.723
2011 Wasko BM, Dudakovic A, Hohl RJ. Bisphosphonates induce autophagy by depleting geranylgeranyl diphosphate. The Journal of Pharmacology and Experimental Therapeutics. 337: 540-6. PMID 21335425 DOI: 10.1124/Jpet.110.175521  0.66
2011 Holstein SA, Hohl RJ. Isoprenoid biosynthetic pathway inhibition disrupts monoclonal protein secretion and induces the unfolded protein response pathway in multiple myeloma cells. Leukemia Research. 35: 551-9. PMID 20828814 DOI: 10.1016/J.Leukres.2010.08.008  0.424
2011 Dandamudi UB, Adams LM, Johnson B, Bauman J, Morris S, Murray S, Webb RT, Gartner E, Hohl R, Lewis LD. Lack of effect of casopitant on the pharmacokinetics of docetaxel in patients with cancer Cancer Chemotherapy and Pharmacology. 67: 783-790. PMID 20556613 DOI: 10.1007/S00280-010-1381-2  0.326
2011 Dudakovic A, Tong H, Hohl RJ. Geranylgeranyl diphosphate depletion inhibits breast cancer cell migration. Investigational New Drugs. 29: 912-20. PMID 20480384 DOI: 10.1007/S10637-010-9446-Y  0.684
2011 Holstein SA, Hohl RJ. Inhibition of Farnesyl and Geranylgeranyl Diphosphate Synthases Enzymes. 30: 301-319. DOI: 10.1016/B978-0-12-415922-8.00013-6  0.391
2010 Ulrich NC, Kuder CH, Hohl RJ, Wiemer DF. Biologically active biotin derivatives of schweinfurthin F. Bioorganic & Medicinal Chemistry Letters. 20: 6716-20. PMID 20869871 DOI: 10.1016/J.Bmcl.2010.08.143  0.762
2010 Barney RJ, Wasko BM, Dudakovic A, Hohl RJ, Wiemer DF. Synthesis and biological evaluation of a series of aromatic bisphosphonates. Bioorganic & Medicinal Chemistry. 18: 7212-20. PMID 20832326 DOI: 10.1016/J.Bmc.2010.08.036  0.66
2010 Topczewski JJ, Kuder CH, Neighbors JD, Hohl RJ, Wiemer DF. Fluorescent schweinfurthin B and F analogs with anti-proliferative activity. Bioorganic & Medicinal Chemistry. 18: 6734-41. PMID 20724169 DOI: 10.1016/J.Bmc.2010.07.056  0.779
2010 Ulrich NC, Kodet JG, Mente NR, Kuder CH, Beutler JA, Hohl RJ, Wiemer DF. Structural analogues of schweinfurthin F: probing the steric, electronic, and hydrophobic properties of the D-ring substructure. Bioorganic & Medicinal Chemistry. 18: 1676-83. PMID 20116262 DOI: 10.1016/J.Bmc.2009.12.063  0.773
2010 Holstein SA, Tong H, Hohl RJ. Differential activities of thalidomide and isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells. Leukemia Research. 34: 344-51. PMID 19646757 DOI: 10.1016/J.Leukres.2009.06.035  0.431
2010 Witzig TE, Hui T, Micallef IN, Ansell SM, Link B, Inwards DJ, Porrata L, Johnston PB, Colgan J, Markovic S, Nowakowski GS, Thompson CA, Allmer C, Maurer MJ, Weiner G, ... Hohl RJ, et al. A Phase II Study of the Farnesyltransferase Inhibitor Tipifarnib Demonstrates Anti-Tumor Activity In Patients with Relapsed and Refractory Lymphomas Blood. 116: 287-287. DOI: 10.1182/Blood.V116.21.287.287  0.319
2009 Holstein SA, Tong H, Kuder CH, Hohl RJ. Quantitative determination of geranyl diphosphate levels in cultured human cells. Lipids. 44: 1055-62. PMID 19856009 DOI: 10.1007/S11745-009-3355-X  0.791
2009 Wiemer AJ, Hohl RJ, Wiemer DF. The intermediate enzymes of isoprenoid metabolism as anticancer targets. Anti-Cancer Agents in Medicinal Chemistry. 9: 526-42. PMID 19519294 DOI: 10.2174/187152009788451860  0.712
2009 Kuder CH, Neighbors JD, Hohl RJ, Wiemer DF. Synthesis and biological activity of a fluorescent schweinfurthin analogue. Bioorganic & Medicinal Chemistry. 17: 4718-23. PMID 19464190 DOI: 10.1016/J.Bmc.2009.04.071  0.78
2009 Chanan-Khan AA, Niesvizky R, Hohl RJ, Zimmerman TM, Christiansen NP, Schiller GJ, Callander N, Lister J, Oken M, Jagannath S. Phase III randomised study of dexamethasone with or without oblimersen sodium for patients with advanced multiple myeloma. Leukemia & Lymphoma. 50: 559-65. PMID 19373653 DOI: 10.1080/10428190902748971  0.302
2008 Tong H, Wiemer AJ, Neighbors JD, Hohl RJ. Quantitative determination of farnesyl and geranylgeranyl diphosphate levels in mammalian tissue. Analytical Biochemistry. 378: 138-43. PMID 18457649 DOI: 10.1016/J.Ab.2008.04.021  0.63
2008 Wiemer AJ, Yu JS, Shull LW, Barney RJ, Wasko BM, Lamb KM, Hohl RJ, Wiemer DF. Pivaloyloxymethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation. Bioorganic & Medicinal Chemistry. 16: 3652-60. PMID 18308574 DOI: 10.1016/J.Bmc.2008.02.016  0.715
2008 Dudakovic A, Wiemer AJ, Lamb KM, Vonnahme LA, Dietz SE, Hohl RJ. Inhibition of geranylgeranyl diphosphate synthase induces apoptosis through multiple mechanisms and displays synergy with inhibition of other isoprenoid biosynthetic enzymes. The Journal of Pharmacology and Experimental Therapeutics. 324: 1028-36. PMID 18083912 DOI: 10.1124/Jpet.107.132217  0.781
2008 Hamadmad SN, Hohl RJ. Erythropoietin stimulates cancer cell migration and activates RhoA protein through a mitogen-activated protein kinase/extracellular signal-regulated kinase-dependent mechanism. The Journal of Pharmacology and Experimental Therapeutics. 324: 1227-33. PMID 18079357 DOI: 10.1124/Jpet.107.129643  0.799
2008 Wiemer AJ, Yu JS, Lamb KM, Hohl RJ, Wiemer DF. Mono- and dialkyl isoprenoid bisphosphonates as geranylgeranyl diphosphate synthase inhibitors. Bioorganic & Medicinal Chemistry. 16: 390-9. PMID 17905588 DOI: 10.1016/J.Bmc.2007.09.029  0.708
2008 Holstein SA, Tong H, Hohl RJ. Biochemical Basis for Interactions Between Thalidomide and Inhibitors of the Isoprenoid Biosynthetic Pathway in Multiple Myeloma Cells Blood. 112: 2635-2635. DOI: 10.1182/Blood.V112.11.2635.2635  0.455
2007 Hamadmad SN, Hohl RJ. Lovastatin suppresses erythropoietin receptor surface expression through dual inhibition of glycosylation and geranylgeranylation. Biochemical Pharmacology. 74: 590-600. PMID 17586475 DOI: 10.1016/J.Bcp.2007.04.028  0.802
2007 Maalouf MA, Wiemer AJ, Kuder CH, Hohl RJ, Wiemer DF. Synthesis of fluorescently tagged isoprenoid bisphosphonates that inhibit protein geranylgeranylation. Bioorganic & Medicinal Chemistry. 15: 1959-66. PMID 17254791 DOI: 10.1016/J.Bmc.2007.01.002  0.787
2007 Mente NR, Wiemer AJ, Neighbors JD, Beutler JA, Hohl RJ, Wiemer DF. Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: differences of bioactivity in the enantiomeric series. Bioorganic & Medicinal Chemistry Letters. 17: 911-5. PMID 17236766 DOI: 10.1016/J.Bmcl.2006.11.096  0.596
2007 Wiemer AJ, Tong H, Swanson KM, Hohl RJ. Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase. Biochemical and Biophysical Research Communications. 353: 921-5. PMID 17208200 DOI: 10.1016/J.Bbrc.2006.12.094  0.706
2006 Shull LW, Wiemer AJ, Hohl RJ, Wiemer DF. Synthesis and biological activity of isoprenoid bisphosphonates. Bioorganic & Medicinal Chemistry. 14: 4130-6. PMID 16517172 DOI: 10.1016/J.Bmc.2006.02.010  0.691
2006 Swanson KM, Hohl RJ. Anti-cancer therapy: targeting the mevalonate pathway. Current Cancer Drug Targets. 6: 15-37. PMID 16475974 DOI: 10.2174/156800906775471743  0.421
2006 Hamadmad SN, Henry MK, Hohl RJ. Erythropoietin receptor signal transduction requires protein geranylgeranylation. The Journal of Pharmacology and Experimental Therapeutics. 316: 403-9. PMID 16203826 DOI: 10.1124/Jpet.105.092510  0.789
2006 Holstein SA, Knapp HR, Clamon GH, Murry DJ, Hohl RJ. Pharmacodynamic effects of high dose lovastatin in subjects with advanced malignancies. Cancer Chemotherapy and Pharmacology. 57: 155-64. PMID 16133537 DOI: 10.1007/S00280-005-0013-8  0.313
2006 Askeland EJ, Wiemer AJ, Hohl RJ. Synergism between Anti-Leukemia Therapeutics and Isoprenoid Pathway Inhibitors in K562 Leukemia Cells. Blood. 108: 4815-4815. DOI: 10.1182/Blood.V108.11.4815.4815  0.71
2005 Murthy S, Tong H, Hohl RJ. Regulation of fatty acid synthesis by farnesyl pyrophosphate. The Journal of Biological Chemistry. 280: 41793-804. PMID 16221687 DOI: 10.1074/Jbc.M504101200  0.354
2005 Lewis KA, Holstein SA, Hohl RJ. Lovastatin alters the isoprenoid biosynthetic pathway in acute myelogenous leukemia cells in vivo. Leukemia Research. 29: 527-33. PMID 15755505 DOI: 10.1016/J.Leukres.2004.10.007  0.371
2005 Tong H, Holstein SA, Hohl RJ. Simultaneous determination of farnesyl and geranylgeranyl pyrophosphate levels in cultured cells. Analytical Biochemistry. 336: 51-9. PMID 15582558 DOI: 10.1016/J.Ab.2004.09.024  0.372
2005 Swanson KM, Tong H, Wiemer AJ, Murthy S, Hohl RJ. Potential mechanisms for the anti-myeloma properties of bisphosphonates Journal of Clinical Oncology. 23: 6586-6586. DOI: 10.1200/Jco.2005.23.16_Suppl.6586  0.705
2004 Kim M, Kleckley TS, Wiemer AJ, Holstein SA, Hohl RJ, Wiemer DF. Synthesis and activity of fluorescent isoprenoid pyrophosphate analogues. The Journal of Organic Chemistry. 69: 8186-93. PMID 15549786 DOI: 10.1021/Jo049101W  0.681
2004 Holstein SA, Hohl RJ. Isoprenoids: remarkable diversity of form and function. Lipids. 39: 293-309. PMID 15357017 DOI: 10.1007/S11745-004-1233-3  0.324
2004 Henry MK, Nimbalkar D, Hohl RJ, Quelle FW. Cytokine-induced phosphoinositide 3-kinase activity promotes Cdk2 activation in factor-dependent hematopoietic cells. Experimental Cell Research. 299: 257-66. PMID 15302592 DOI: 10.1016/J.Yexcr.2004.06.003  0.397
2004 Swanson KM, Wiemer AJ, Hohl RJ. Bisphosphonates Influence Isoprenylation of Small Gtpases in Human Myeloma Cells. Blood. 104: 3401-3401. DOI: 10.1182/Blood.V104.11.3401.3401  0.706
2004 Sbaity SA, Murthy S, Romig S, Hohl R, Weintraub N, Stoll L. 1122-169 Statins block endotoxin-induced proinflammatory responses in human coronary artery cells by inhibition of Rho protein-mediated signaling Journal of the American College of Cardiology. 43: A498. DOI: 10.1016/S0735-1097(04)92108-0  0.323
2003 Ownby SE, Hohl RJ. Isoprenoid alcohols restore protein isoprenylation in a time-dependent manner independent of protein synthesis. Lipids. 38: 751-9. PMID 14506838 DOI: 10.1007/S11745-003-1123-8  0.781
2003 Holstein SA, Wohlford-Lenane CL, Wiemer DF, Hohl RJ. Isoprenoid pyrophosphate analogues regulate expression of Ras-related proteins. Biochemistry. 42: 4384-91. PMID 12693933 DOI: 10.1021/Bi027227M  0.359
2003 Holstein SA, Hohl RJ. Monoterpene regulation of Ras and Ras-related protein expression. Journal of Lipid Research. 44: 1209-15. PMID 12671036 DOI: 10.1194/Jlr.M300057-Jlr200  0.349
2002 Chen X, Wiemer AJ, Hohl RJ, Wiemer DF. Stereoselective synthesis of the 5'-hydroxy-5'-phosphonate derivatives of cytidine and cytosine arabinoside. The Journal of Organic Chemistry. 67: 9331-9. PMID 12492335 DOI: 10.1021/Jo020483K  0.649
2002 Holstein SA, Wohlford-Lenane CL, Hohl RJ. Isoprenoids influence expression of Ras and Ras-related proteins. Biochemistry. 41: 13698-704. PMID 12427032 DOI: 10.1021/Bi026251X  0.322
2002 Ownby SE, Hohl RJ. Farnesol and geranylgeraniol: prevention and reversion of lovastatin-induced effects in NIH3T3 cells. Lipids. 37: 185-92. PMID 11908910 DOI: 10.1007/S11745-002-0879-1  0.789
2002 Holstein SA, Wohlford-Lenane CL, Hohl RJ. Consequences of mevalonate depletion. Differential transcriptional, translational, and post-translational up-regulation of Ras, Rap1a, RhoA, AND RhoB. The Journal of Biological Chemistry. 277: 10678-82. PMID 11788600 DOI: 10.1074/Jbc.M111369200  0.32
2002 Chen X, Jung KY, Wiemer DF, Wiemer AJ, Hohl RJ. Phosphonate analogues of cytosine arabinoside monophosphate Phosphorus, Sulfur and Silicon and Related Elements. 177: 1783-1786. DOI: 10.1080/10426500212248  0.656
2001 Holstein SA, Hohl RJ. Synergistic interaction of lovastatin and paclitaxel in human cancer cells Molecular Cancer Therapeutics. 1: 141-149. PMID 12467231  0.316
2001 Holstein SA, Hohl RJ. Interaction of cytosine arabinoside and lovastatin in human leukemia cells Leukemia Research. 25: 651-660. PMID 11397469 DOI: 10.1016/S0145-2126(00)00162-4  0.354
2000 Cermak DM, Wiemer DF, Lewis K, Hohl RJ. 2-(Acyloxy)ethylphosphonate analogues of prenyl pyrophosphates: synthesis and biological characterization Bioorganic and Medicinal Chemistry. 8: 2729-2737. PMID 11131164 DOI: 10.1016/S0968-0896(00)00212-1  0.377
2000 Jung KY, Hohl RJ, Wiemer AJ, Wiemer DF. Synthesis of phosphonate derivatives of uridine, cytidine, and cytosine arabinoside. Bioorganic & Medicinal Chemistry. 8: 2501-9. PMID 11058045 DOI: 10.1016/S0968-0896(00)00183-8  0.658
1998 Holstein SA, Cermak DM, Wiemer DF, Lewis K, Hohl RJ. Phosphonate and bisphosphonate analogues of farnesyl pyrophosphate as potential inhibitors of farnesyl protein transferase Bioorganic and Medicinal Chemistry. 6: 687-694. PMID 9681134 DOI: 10.1016/S0968-0896(98)00034-0  0.363
1998 Hohl RJ, Lewis KA, Cermak DM, Wiemer DF. Stereochemistry-dependent inhibition of RAS farnesylation by farnesyl phosphonic acids Lipids. 33: 39-46. PMID 9470172 DOI: 10.1007/S11745-998-0178-X  0.346
1996 Goldman F, Hohl RJ, Crabtree J, Lewis-Tibesar K, Koretzky G. Lovastatin inhibits T-cell antigen receptor signaling independent of its effects on ras Blood. 88: 4611-4619. PMID 8977253 DOI: 10.1182/Blood.V88.12.4611.Bloodjournal88124611  0.382
1996 Hohl RJ. Monoterpenes as regulators of malignant cell proliferation Advances in Experimental Medicine and Biology. 401: 137-146. PMID 8886132 DOI: 10.1007/978-1-4613-0399-2_11  0.344
1995 Hohl RJ, Lewis K. Differential effects of monoterpenes and lovastatin on RAS processing Journal of Biological Chemistry. 270: 17508-17512. PMID 7615555 DOI: 10.1074/Jbc.270.29.17508  0.325
1991 Hohl RJ, Larson RA, Mannickarottu V, Yachnin S. Inhibition of hydroxymethylglutaryl coenzyme A reductase activity induces a paradoxical increase in DNA synthesis in myeloid leukemia cells Blood. 77: 1064-1070. PMID 1995091 DOI: 10.1182/Blood.V77.5.1064.Bloodjournal7751064  0.358
Low-probability matches (unlikely to be authored by this person)
2018 Zhao C, Jia B, Wang L, Claxton DF, Ehmann WC, Rybka WB, Mineishi S, Naik S, Songdej N, Khawaja M, Hohl RJ, Zheng H. Multi-Dimensional Analysis of Immune Signature Predicts Response to Decitabine Treatment in Elderly Patients with AML Blood. 132: 1526-1526. DOI: 10.1182/Blood-2018-99-113547  0.299
2012 Holstein SA, Hohl RJ. Therapeutic additions and possible deletions in oncology in 2011 Clinical Pharmacology and Therapeutics. 91: 15-17. PMID 22179625 DOI: 10.1038/Clpt.2011.288  0.299
1997 Lewis KA, Hohl RJ. Modulation of RAS expression in human malignant cells by dietary supplements Nutrition. 13: 921-923. PMID 9357036 DOI: 10.1016/S0899-9007(97)00261-X  0.297
2016 Raje N, Faber E, Richardson PG, Schiller G, Hohl RJ, Cohen AD, Forero A, Carpenter S, Nguyen TS, Conti I, Kaiser C, Cronier DM, Wooldridge JE, Anderson KC. Phase 1 study of tabalumab, a human anti-B-cell activating factor antibody, and bortezomib in patients with relapsed/refractory multiple myeloma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27287072 DOI: 10.1158/1078-0432.Ccr-16-0201  0.297
2019 Weissenrieder JS, Reed JL, Green MV, Moldovan GL, Koubek EJ, Neighbors JD, Hohl RJ. The Dopamine D2 Receptor Contributes to the Spheroid Formation Behavior of U87 Glioblastoma Cells. Pharmacology. 1-9. PMID 31645049 DOI: 10.1159/000502562  0.295
2016 Pu JJ, Ehmann WC, Liao J, Capper C, Levy M, Claxton DF, Rybka WB, Hohl RJ, Epner EM. The Results of a Phase I Study using Velcade (Bortezomib), Cladribine, and Rituximab (VCR) in treating Mantle Cell Lymphoma Blood. 128: 1792-1792. DOI: 10.1182/Blood.V128.22.1792.1792  0.295
2017 Schoenfeld JD, Sibenaller ZA, Mapuskar KA, Wagner BA, Cramer-Morales KL, Furqan M, Sandhu S, Carlisle TL, Smith MC, Abu Hejleh T, Berg DJ, Zhang J, Keech J, Parekh KR, Bhatia S, ... ... Hohl RJ, et al. O2(⋅-) and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate. Cancer Cell. 32: 268. PMID 28810149 DOI: 10.1016/J.Ccell.2017.07.008  0.294
2004 Hohl R. Statins decrease levels of the estrogen receptor in human breast cancers Clinical Pharmacology & Therapeutics. 75: P45. DOI: 10.1016/J.Clpt.2003.11.170  0.291
2006 Sokol L, Cripe L, Kantarjian H, Sekeres MA, Parmar S, Greenberg P, Goldberg S, Bhushan V, Shammo J, Hohl R, Li Y, Lowe A, Zhu J, List A. Phase I/II, Randomized, MultiCenter, Dose-Ascension Study of the p38MAPK Inhibitor Scio-469 in Patients with Myelodysplastic Syndrome (MDS). Blood. 108: 2657-2657. DOI: 10.1182/Blood.V108.11.2657.2657  0.291
2007 Xing D, Murry DJ, Schmidt MS, Hohl RJ, Martins JB. Lovastatin specifically prevents focal ischemic ventricular tachycardia due to triggered activity. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 4: 629-37. PMID 17467633 DOI: 10.1016/J.Hrthm.2006.12.051  0.291
2011 Raje NS, Hohl RJ, Faber EA, Richardson PG, Forero-Torres A, Schiller GJ, Cohen AD, Carpenter SP, Cronier D, Pashkevich M, Wooldridge J, Anderson KC. Phase I study of LY2127399, a human anti-BAFF antibody, and bortezomib in patients with previously treated multiple myeloma. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 8012. PMID 28022991 DOI: 10.1200/Jco.2011.29.15_Suppl.8012  0.291
2004 Chanan-Khan AA, Niesvizky R, Hohl RJ, Zimmerman TM, Christiansen NP, Schiller GJ, Smith S, Frankel S. Randomized Multicenter Phase 3 Trial of High-Dose Dexamethasone (dex) with or without Oblimersen Sodium (G3139; Bcl-2 antisense; Genasense) for Patients with Advanced Multiple Myeloma (MM). Blood. 104: 1477-1477. DOI: 10.1182/Blood.V104.11.1477.1477  0.291
2019 Weissenrieder JS, Neighbors JD, Mailman RB, Hohl RJ. Cancer and the dopamine D2 receptor: a pharmacological perspective. The Journal of Pharmacology and Experimental Therapeutics. PMID 31000578 DOI: 10.1124/Jpet.119.256818  0.29
2017 Jia B, Wang L, Claxton DF, Ehmann WC, Rybka WB, Mineishi S, Shike H, Bayerl M, Schell TD, Hohl RJ, Zheng H. Bone Marrow CD8 T Cells Express High Frequency of PD-1 and Exhibit Reduced Anti-Leukemia Response in AML Patients Blood. 130: 3946-3946. DOI: 10.1182/Blood.V130.Suppl_1.3946.3946  0.288
2005 Magalhaes-Silverman M, Carter T, Gingrich R, Hohl R, Schlueter A. In vivo T cell depleted unrelated allogeneic stem cell transplantation with a reduced intensity regimen in patients with advanced hematologic malignancies Biology of Blood and Marrow Transplantation. 11: 22-23. DOI: 10.1016/J.Bbmt.2004.12.065  0.287
1996 Hohl R, Pogatchnik DM, Lewis-Tibesar K, Wiemer D. Inhibition of RAS farnesylation by isoprenoid phosphonic acids. Clinical Pharmacology & Therapeutics. 59: 198-198. DOI: 10.1038/Sj.Clpt.1996.290  0.285
2019 Jia B, Zhao C, Rakszawski KL, Claxton DF, Ehmann WC, Rybka WB, Mineishi S, Wang M, Shike H, Bayerl MG, Sivik JM, Schell TD, Drabick JJ, Hohl RJ, Zheng H. Eomes+T-betlow CD8+ T cells are functionally impaired and are associated with poor clinical outcome in patients with acute myeloid leukemia (AML). Cancer Research. PMID 30709927 DOI: 10.1158/0008-5472.Can-18-3107  0.284
2015 Holstein SA, Bigelow JC, Olson RD, Vestal RE, Walsh GM, Hohl RJ. Phase I and pharmacokinetic study of the novel anthracycline derivative 5-imino-13-deoxydoxorubicin (GPX-150) in patients with advanced solid tumors. Investigational New Drugs. 33: 594-602. PMID 25698442 DOI: 10.1007/S10637-015-0220-Z  0.283
2017 Teye EK, Sido A, Xin P, Finnberg NK, Gokare P, Kawasawa YI, Salzberg AC, Shimko S, Bayerl M, Ehmann WC, Claxton DF, Rybka WB, Drabik JJ, Wang HG, Abraham T, ... ... Hohl RJ, et al. PIGN gene expression aberration is associated with genomic instability and leukemic progression in acute myeloid leukemia with myelodysplastic features. Oncotarget. PMID 28187452 DOI: 10.18632/Oncotarget.15136  0.282
2003 Magalhaes-Silverman M, Lee C, Hohl R, Ritchie J, Gingrich R. 71 T-cell depleted allogeneic bone marrow transplantation followed by T cell add-back in patients with multiple myeloma Biology of Blood and Marrow Transplantation. 9: 86. DOI: 10.1016/S1083-8791(03)80072-1  0.276
1995 Clamon GH, Riggs CE, Dreicer R, Hohl RJ. Phase II trial of edatrexate in patients with metastatic colorectal cancer Investigational New Drugs. 13: 359-361. PMID 8824357 DOI: 10.1007/Bf00873145  0.276
2006 Rosenberg JE, Halabi S, Sanford BL, Himelstein AL, Atkins JN, Hohl R, Seagren SL, Bajorin DF, Small EJ. CALGB 90207: Phase II trial of bortezomib in patients with previously treated advanced urothelial tract transitional cell carcinoma (TCC) Journal of Clinical Oncology. 24: 4582-4582. DOI: 10.1200/Jco.2006.24.18_Suppl.4582  0.276
2008 Rosenberg JE, Halabi S, Sanford BL, Himelstein AL, Atkins JN, Hohl RJ, Millard F, Bajorin DF, Small EJ. Phase II study of bortezomib in patients with previously treated advanced urothelial tract transitional cell carcinoma: CALGB 90207 Annals of Oncology. 19: 946-950. PMID 18272914 DOI: 10.1093/Annonc/Mdm600  0.275
1998 Gao F, Hohl RJ, Shires TK. Geranylgeraniol restores cell growth and Ras processing in mevalonate-depleted fibroblast cells Faseb Journal. 12.  0.274
2013 Xia C, Deutsch JM, Milhem MM, Smith BJ, Laux D, Hohl R. Abstract 2414: A phase I/II clinical trial to evaluate the efficacy of combined epigenetic therapy for improving temozolomide chemosensitivity in metastatic melanoma. Cancer Research. 73: 2414-2414. DOI: 10.1158/1538-7445.Am2013-2414  0.274
2012 Raje N, Faber EA, Richardson PG, Schiller GJ, Hohl RJ, Cohen AD, Forero A, Carpenter SP, Cronier D, Kaiser C, Wooldridge JE, Anderson KC. Phase 1 Study of Tabalumab, a Human Anti-BAFF Antibody and Bortezomib in Patients with Previously-Treated Multiple Myeloma Blood. 120: 447-447. DOI: 10.1182/Blood.V120.21.447.447  0.272
2003 Hohl RJ, Holstein SA, Wohlford-Lenane CL. Mevalonate depletion induces up-regulation of RAS and RAS-related proteins Clinical Pharmacology & Therapeutics. 73: P67-P67. DOI: 10.1016/S0009-9236(03)90606-0  0.272
2005 Stroh A, Carter TH, Hohl RJ, Zehr P, Ritchie JM. Pilot Study of Lovastatin in Patients with Myelodysplastic Syndrome (MDS) Receiving Arsenic Trioxide (Trisenox®) Therapy. Blood. 106: 4928-4928. DOI: 10.1182/Blood.V106.11.4928.4928  0.27
2009 Holstein SA, Stokes JB, Hohl RJ. Renal failure and recovery associated with second-generation Bcr-Abl kinase inhibitors in imatinib-resistant chronic myelogenous leukemia. Leukemia Research. 33: 344-7. PMID 18835038 DOI: 10.1016/J.Leukres.2008.07.029  0.269
2002 Lee CK, de Magalhaes-Silverman M, Hohl RJ, Hayashi M, Buatti J, Wen BC, Schlueter A, Strauss RG, Gingrich RD. Prophylactic T cell infusion after T cell-depleted bone marrow transplantation in patients with refractory lymphoma Bone Marrow Transplantation. 29: 615-620. PMID 11979313 DOI: 10.1038/Sj.Bmt.1703426  0.268
1999 Gingrich RD, Lee C, Hohl R, Joyce J, Burns LJ, Tamaki K, Wen B, Scott S. A novel four-drug ablative regimen with hemopoietic stem cell rescue for patients with breast cancer: A phase II study Biology of Blood and Marrow Transplantation. 5: 86-93. PMID 10371360 DOI: 10.1053/Bbmt.1999.V5.Pm10371360  0.267
2001 Kumar V, Kang J, Hohl RJ. Improved dissolution and cytotoxicity of camptothecin incorporated into oxidized-cellulose microspheres prepared by spray drying Pharmaceutical Development and Technology. 6: 459-467. PMID 11485187 DOI: 10.1081/Pdt-100002254  0.267
2004 Bailey HH, Wilding G, Tutsch KD, Arzoomanian RZ, Alberti D, Feierabend C, Simon K, Marnocha R, Holstein SA, Stewart J, Lewis KA, Hohl RJ. A phase I trial of perillyl alcohol administered four times daily for 14 days out of 28 days. Cancer Chemotherapy and Pharmacology. 54: 368-76. PMID 15205914 DOI: 10.1007/S00280-004-0788-Z  0.265
2012 Xia C, Laux DE, Deutsch JM, Frees M, Smith B, Hohl RJ, Milhem MM. A phase I/II study to evaluate the ability of decitabine and panobinostat to improve temozolomide chemosensitivity in metastatic melanoma. Journal of Clinical Oncology. 30: 3056-3056. DOI: 10.1200/Jco.2012.30.15_Suppl.3056  0.264
2018 Jia B, Wang L, Claxton DF, Ehmann WC, Rybka WB, Mineishi S, Rizvi S, Shike H, Bayerl M, Schell TD, Hohl RJ, Zheng H. Bone marrow CD8 T cells express high frequency of PD-1 and exhibit reduced anti-leukemia response in newly diagnosed AML patients. Blood Cancer Journal. 8: 34. PMID 29563517 DOI: 10.1038/S41408-018-0069-4  0.263
2019 Zhao C, Jia B, Wang M, Schell TD, Claxton DF, Ehmann WC, Rybka WB, Mineishi S, Naik S, Songdej N, Sivik JM, Hohl RJ, Zeng H, Zheng H. Multi-dimensional analysis identifies an immune signature predicting response to decitabine treatment in elderly patients with AML. British Journal of Haematology. PMID 31573077 DOI: 10.1111/Bjh.16228  0.261
2013 Sokol L, Cripe L, Kantarjian H, Sekeres MA, Parmar S, Greenberg P, Goldberg SL, Bhushan V, Shammo J, Hohl R, Verma A, Garcia-Manero G, Li YP, Lowe A, Zhu J, et al. Randomized, dose-escalation study of the p38α MAPK inhibitor SCIO-469 in patients with myelodysplastic syndrome. Leukemia. 27: 977-80. PMID 23032694 DOI: 10.1038/Leu.2012.264  0.258
2022 Weissenrieder JS, Weissenkampen JD, Reed JL, Green MV, Zheng C, Neighbors JD, Liu DJ, Hohl RJ. RNAseq reveals extensive metabolic disruptions in the sensitive SF-295 cell line treated with schweinfurthins. Scientific Reports. 12: 359. PMID 35013404 DOI: 10.1038/s41598-021-04117-7  0.258
2003 Veng-Pedersen P, Chapel S, Al-Huniti NH, Schmidt RL, Sedars EM, Hohl RJ, Widness JA. A differential pharmacokinetic analysis of the erythropoietin receptor population in newborn and adult sheep Journal of Pharmacology and Experimental Therapeutics. 306: 532-537. PMID 12750427 DOI: 10.1124/Jpet.103.052431  0.258
2007 Schlueter AJ, Glasgow JK, Wilke W, Marietta JR, Hohl RJ, Carter TH, Gingrich RD, Magalhaes-Silverman MD. Dendritic Cell Reconstitution Following Autologous Stem Cell Transplant with GM-CSF Support for Multiple Myeloma. Blood. 110: 951-951. DOI: 10.1182/Blood.V110.11.951.951  0.257
2000 Venook AP, Egorin MJ, Rosner GL, Hollis D, Mani S, Hawkins M, Byrd J, Hohl R, Budman D, Meropol NJ, Ratain MJ. Phase I and pharmacokinetic trial of gemcitabine in patients with hepatic or renal dysfunction: Cancer and leukemia group B 9565 Journal of Clinical Oncology. 18: 2780-2787. PMID 10894879 DOI: 10.1200/Jco.2000.18.14.2780  0.257
2001 Hohl RJ, Holstein SA. Synergy of cytosine arabinoside and lovastatin in human leukemia cells Clinical Pharmacology and Therapeutics. 69.  0.256
2015 Osborn-Heaford HL, Murthy S, Gu L, Larson-Casey JL, Ryan AJ, Shi L, Glogauer M, Neighbors JD, Hohl R, Brent Carter A. Targeting the isoprenoid pathway to abrogate progression of pulmonary fibrosis. Free Radical Biology & Medicine. 86: 47-56. PMID 25958207 DOI: 10.1016/J.Freeradbiomed.2015.04.031  0.255
2007 Holstein SA, Knapp HR, Clamon GH, Murry DJ, Hohl RJ. Erratum: Pharmacodynamic effects of high dose lovastatin in subjects with advanced malignancies (Cancer Chemotherapy and Pharmacology 57, (155-164) DOI: 10.1007/s00280-005-0013-8) Cancer Chemotherapy and Pharmacology. 59. DOI: 10.1007/S00280-006-0330-6  0.255
2020 Bluethmann SM, Wang M, Wasserman E, Chen C, Zaorsky NG, Hohl RJ, McDonald AC. Prostate cancer in Pennsylvania: The role of older age at diagnosis, aggressiveness, and environmental risk factors on treatment and mortality using data from the Pennsylvania Cancer Registry. Cancer Medicine. PMID 32212232 DOI: 10.1002/Cam4.3003  0.254
2005 Schlueter AJ, Glasgow JK, Wilke WW, Marietta JR, Hohl RJ, Carter TH, Gingrich RD, Magalhaes-Silverman MD. Dendritic Cell Reconstitution Following Autologous Stem Cell Transplant for Multiple Myeloma. Blood. 106: 5212-5212. DOI: 10.1182/Blood.V106.11.5212.5212  0.254
2006 Siegel DS, Krishnan A, Lonial S, Chatta G, Alsina M, Jagannath S, Richardson P, Hohl RJ, Lust JA, Bensinger W, Carrum G, Moreb J, Simic A, Barlogie B, Maziarz RT, et al. Phase II Trial of SCIO-469 as Monotherapy (M) or in Combination with Bortezomib (MB) in Relapsed Refractory Multiple Myeloma (MM). Blood. 108: 3580-3580. DOI: 10.1182/Blood.V108.11.3580.3580  0.254
2018 Poulose J, Pu JJ, Malysz J, Bayerl M, Fanburg-Smith J, Hohl RJ, Mineishi S, Zhu J. Impact of ruxolitinib in myelofibrosis post allogeneic stem cell transplant: A pilot study. Journal of Clinical Oncology. 36: 7071-7071. DOI: 10.1200/Jco.2018.36.15_Suppl.7071  0.253
2013 Hohl RJ, Vestal RE, Holstein SA, Olson RD, Parrott K, Walsh GM. Phase I dose-escalation clinical trial with 5-imino-13-deoxydoxorubicin in cancer patients. Journal of Clinical Oncology. 31: 2575-2575. DOI: 10.1200/Jco.2013.31.15_Suppl.2575  0.252
1998 Venook AP, Egorin MJ, Rosner GL, Brown TD, Jahan TM, Batist G, Hohl R, Budman D, Ratain MJ, Kearns CM, Schilsky RL. Phase I and pharmacokinetic trial of paclitaxel in patients with hepatic dysfunction: Cancer and leukemia group B 9264 Journal of Clinical Oncology. 16: 1811-1819. PMID 9586895 DOI: 10.1200/Jco.1998.16.5.1811  0.252
2009 Byrd JC, Peterson BL, Rai KR, Hurd D, Hohl R, Perry MC, Gockerman J, Nattam S, Larson RA. Fludarabine followed by alemtuzumab consolidation for previously untreated chronic lymphocytic leukemia: final report of Cancer and Leukemia Group B study 19901. Leukemia & Lymphoma. 50: 1589-96. PMID 19863336 DOI: 10.1080/10428190903150839  0.252
2005 HOHL R, WIDNESS J, ROBERT S, GOLDMAN F, ALHUNITI N, VENGPEDERSON P. Change in erythropoietin pharmacokinetics in patients receiving hematopoietic stem cell transplantation Clinical Pharmacology & Therapeutics. 77: P16-P16. DOI: 10.1016/J.Clpt.2004.11.064  0.251
1999 Lee CK, Gingrich RD, DeMagalhaes-Silverman M, Hohl RJ, Joyce JK, Scott SD, Wen BC, Schlueter A. Prophylactic reinfusion of T cells for T cell-depleted allogeneic bone marrow transplantation Biology of Blood and Marrow Transplantation. 5: 15-27. PMID 10232737 DOI: 10.1053/Bbmt.1999.V5.Pm10232737  0.25
2019 Bodeker KL, Allen BG, Smith MC, Monga V, Sandhu S, Hohl RJ, Carlisle TL, Brown HA, Hollenbeck NJ, Vollstedt S, Greenlee JDW, Howard MA, Mapuskar KA, Seyedin SN, Caster JM, et al. First-in-human phase 1 clinical trial of pharmacological ascorbate combined with radiation and temozolomide for newly diagnosed glioblastoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31427282 DOI: 10.1158/1078-0432.Ccr-19-0594  0.249
2002 Lee CK, deMagalhaes-Silverman M, Hayashi M, Schlueter A, Strauss RG, Hohl RJ, Gingrich RD. A dose escalation study for salvage chemotherapy in patients with refractory lymphoma prior to high-dose myeloablative therapy with stem cell transplantation Bone Marrow Transplantation. 29: 647-652. PMID 12180108 DOI: 10.1038/Sj.Bmt.1703533  0.247
2007 Widness JA, Schmidt RL, Hohl RJ, Goldman FD, Al-Huniti NH, Freise KJ, Veng-Pedersen P. Change in erythropoietin pharmacokinetics following hematopoietic transplantation Clinical Pharmacology and Therapeutics. 81: 873-879. PMID 17429351 DOI: 10.1038/Sj.Clpt.6100165  0.246
2015 Ferguson NN, Thomas CP, Hohl RJ, Syrbu SI, Stone MS, Wanat KA. Primary Cutaneous Polymorphic EBV-Associated Posttransplant Lymphoproliferative Disorder After a Renal Transplant and Review of the Literature. The American Journal of Dermatopathology. PMID 25747810 DOI: 10.1097/Dad.0000000000000272  0.246
2017 Hohl RJ. Anticoagulants: Major Advances Without Clear Consensus. Clinical Pharmacology and Therapeutics. 100: 116-8. PMID 27393187 DOI: 10.1002/Cpt.399  0.246
2020 Wang M, Wasserman E, Geyer N, Carroll RM, Zhao S, Zhang L, Hohl R, Lengerich EJ, McDonald AC. Spatial patterns in prostate Cancer-specific mortality in Pennsylvania using Pennsylvania Cancer registry data, 2004-2014. Bmc Cancer. 20: 394. PMID 32375682 DOI: 10.1186/S12885-020-06902-5  0.243
2000 Yung WK, Albright RE, Olson J, Fredericks R, Fink K, Prados MD, Brada M, Spence A, Hohl RJ, Shapiro W, Glantz M, Greenberg H, Selker RG, Vick NA, Rampling R, et al. A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse. British Journal of Cancer. 83: 588-93. PMID 10944597 DOI: 10.1054/Bjoc.2000.1316  0.241
2003 Venook AP, Klein CE, Fleming G, Hollis D, Leichman CG, Hohl R, Byrd J, Budman D, Villalona M, Marshall J, Rosner GL, Ramirez J, Kastrissios H, Ratain MJ. A phase I and pharmacokinetic study of irinotecan in patients with hepatic or renal dysfunction or with prior pelvic radiation: CALGB 9863 Annals of Oncology. 14: 1783-1790. PMID 14630685 DOI: 10.1093/Annonc/Mdg493  0.24
2005 Magalhaes-Silverman M, Carter T, Hohl R, Shamsuddin H, Gingrich R. Vanganciclovir prophylaxis for the prevention of cytomegalovirus reactivation and disease in allogeneic stem cell transplantation recipients Biology of Blood and Marrow Transplantation. 11: 87-88. DOI: 10.1016/J.Bbmt.2004.12.258  0.24
2017 Lee J, Blumenthal GM, Hohl RJ, Huang SM. Cancer Therapy: Shooting for the Moon. Clinical Pharmacology and Therapeutics. 101: 552-558. PMID 28418166 DOI: 10.1002/Cpt.655  0.237
2022 Manfredi B, Neighbors JD, Hohl RJ. Cytotoxic Effects of the Schweinfurthin Analog 5'-Methylschweinfurthin G in Malignant Plasma Cells. Pharmacology. 1-14. PMID 35810739 DOI: 10.1159/000525299  0.236
1989 Hohl RJ, Schilsky RL. Nonmalignant complications of therapy for Hodgkin's disease Hematology/Oncology Clinics of North America. 3: 331-343. PMID 2663831 DOI: 10.1016/S0889-8588(18)30560-4  0.236
2019 Zheng H, Mineishi S, Claxton DF, Zhu J, Zhao C, Jia B, Ehmann WC, Naik S, Songdej N, Hohl RJ. Effect of Avelumab to Immune Response in AML: A Phase I Study of Avelumab in Combination with Decitabine As First Line Treatment of Unfit Patients Blood. 134: 3939-3939. DOI: 10.1182/Blood-2019-125153  0.234
2019 McDonald AC, Wasserman E, Lengerich EJ, Raman JD, Geyer N, Hohl R, Wang M. Abstract 4186: Aggressive prostate cancer among men in Pennsylvania: Differences between Appalachian and non-Appalachian counties Epidemiology. DOI: 10.1158/1538-7445.Sabcs18-4186  0.233
2005 Magalhaes-Silverman M, Carter T, Hohl R, Shamsuddin H, Gingrich R. Antifungal prophylaxis with voriconazole in allogeneic hematopoietic stem cell transplantation recipients Biology of Blood and Marrow Transplantation. 11: 89. DOI: 10.1016/J.Bbmt.2004.12.262  0.231
2016 Ferguson SD, Xiu J, Weathers SP, Zhou S, Kesari S, Weiss SE, Verhaak RG, Hohl RJ, Barger GR, Reddy SK, Heimberger AB. GBM-associated mutations and altered protein expression are more common in young patients. Oncotarget. PMID 27579614 DOI: 10.18632/Oncotarget.11617  0.23
2016 Xiu J, Reddy SK, Kesari S, McLaughlin SE, Hohl RJ, Barger G, Heimberger AB. Comparison of molecular alteration in glioblastoma tumors from old and young patients. Journal of Clinical Oncology. 34: 2056-2056. DOI: 10.1200/Jco.2016.34.15_Suppl.2056  0.23
2020 McDonald AC, Wasserman E, Lengerich EJ, Raman JD, Geyer NR, Hohl RJ, Wang M. Prostate Cancer Incidence and Aggressiveness in Appalachia versus Non-Appalachia Populations in Pennsylvania by Urban-Rural Regions, 2004-2014. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. PMID 32277006 DOI: 10.1158/1055-9965.Epi-19-1232  0.227
2006 Foss F, Duvic M, Geskin L, Anderson J, Porcu P, Hohl RJ, Cooper M, Zain JM, Zic J, Hibberd P, Acosta M. Efficacy and Safety of Denileukin Diftitox (Ontak®) in the Treatment of Cutaneous T-Cell Lymphoma (CTCL) According to CD25 Status. Blood. 108: 2712-2712. DOI: 10.1182/Blood.V108.11.2712.2712  0.226
1997 Hohl RJ, Pogatchnik DM, Lewis-Tibesar K, Wiemer DF. Differential inhibition of farnesyl protein transferase and squalene synthase by isoprenoid phosphonic acids Clinical Pharmacology and Therapeutics. 61: 144.  0.225
2008 McLennan G, Clarke L, Hohl RJ. Imaging as a biomarker for therapy response: Cancer as a prototype for the creation of research resources Clinical Pharmacology and Therapeutics. 84: 433-436. PMID 18802422 DOI: 10.1038/Clpt.2008.171  0.224
1996 Thibault A, Samid D, Tompkins AC, Figg WD, Cooper MR, Hohl RJ, Trepel J, Liang B, Patronas N, Venzon DJ, Reed E, Myers CE. Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer Clinical Cancer Research. 2: 483-491. PMID 9816194  0.222
2005 Xing D, Hohl R, Martins J. Lovastatin is antiarrhythmic in ischemic heart tissue by blocking triggered activity Heart Rhythm. 2: S217. DOI: 10.1016/J.Hrthm.2005.02.679  0.221
2014 Hohl RJ. Drug development (and academic medicine): charting the course forward Clinical Pharmacology and Therapeutics. 96: 519-522. PMID 25336261 DOI: 10.1038/Clpt.2014.171  0.22
2012 Gronchi A, Bui BN, Bonvalot S, Pilotti S, Ferrari S, Hohenberger P, Hohl RJ, Demetri GD, Le Cesne A, Lardelli P, Pérez I, Nieto A, Tercero JC, Alfaro V, Tamborini E, et al. Phase II clinical trial of neoadjuvant trabectedin in patients with advanced localized myxoid liposarcoma. Annals of Oncology : Official Journal of the European Society For Medical Oncology / Esmo. 23: 771-6. PMID 21642514 DOI: 10.1093/Annonc/Mdr265  0.218
2010 Phillips PS, Verity MA, Schick BA, Vladutiu GD, Laaksonen R, Oresic M, Hohl RJ, Ciaraldi TP, Sukhatme VP, Lecker SH, Cote HCF, Powell H, Davidson W, Wolfson T. Survey of muscle characteristics after statin-induced rhabdomyolysis Clinical Lipidology. 5: 17-27. DOI: 10.2217/Clp.09.83  0.218
2008 Ryken T, Carlisle T, Buatti J, Kirby P, Maley J, Hohl R, Smith BJ, Greenlee J, Frees M, Rogers M. Treatment of adults with newly diagnosed glioblastoma multiforme or anaplastic astrocytoma with surgery, gliadel wafers and limited field radiation plus concomitant temozolomide followed by adjuvant temozolomide. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 26: 13003. PMID 27951249 DOI: 10.1200/Jco.2008.26.15_Suppl.13003  0.216
2013 Hohl RJ. Personalized medicine: through the looking glass of functional imaging. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 4024-6. PMID 23785049 DOI: 10.1158/1078-0432.Ccr-13-1129  0.215
2012 Malchenko S, Seftor EA, Nikolsky Y, Hasegawa SL, Kuo S, Stevens JW, Poyarkov S, Nikolskaya T, Kucaba T, Wang M, Abdulkawy H, Casavant T, Morcuende J, Buckwalter J, Hohl R, et al. Putative multifunctional signature of lung metastases in dedifferentiated chondrosarcoma. Sarcoma. 2012: 820254. PMID 22448124 DOI: 10.1155/2012/820254  0.215
2019 Huang X, Sterling NW, Du G, Sun D, Stetter C, Kong L, Zhu Y, Neighbors J, Lewis MM, Chen H, Hohl RJ, Mailman RB. Brain cholesterol metabolism and Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 30681742 DOI: 10.1002/Mds.27609  0.212
2011 Waldman SA, Hohl RJ, Kearns GL, Swan SJ, Terzic A. Clinical pharmacology as a foundation for translational science Clinical Pharmacology and Therapeutics. 90: 10-13. PMID 21691266 DOI: 10.1038/Clpt.2011.80  0.212
2007 Miller AA, Murry DJ, Owzar K, Hollis DR, Lewis LD, Kindler HL, Marshall JL, Villalona-Calero MA, Edelman MJ, Hohl RJ, Lichtman SM, Ratain MJ. Phase I and pharmacokinetic study of erlotinib for solid tumors in patients with hepatic or renal dysfunction: CALGB 60101. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 25: 3055-60. PMID 17634483 DOI: 10.1200/Jco.2007.11.6210  0.21
1998 Hohl RJ, Sherburne AR, Feeley JE, Huisman THJ, Burns CP. Low pulse oximeter-measured hemoglobin oxygen saturations with hemoglobin Cheverly American Journal of Hematology. 59: 181-184. PMID 9798654 DOI: 10.1002/(Sici)1096-8652(199811)59:3<181::Aid-Ajh1>3.0.Co;2-I  0.21
2009 Miller AA, Murry DJ, Owzar K, Hollis DR, Kennedy EB, Abou-Alfa G, Desai A, Hwang J, Villalona-Calero MA, Dees EC, Lewis LD, Fakih MG, Edelman MJ, Millard F, Frank RC, ... Hohl RJ, et al. Phase I and pharmacokinetic study of sorafenib in patients with hepatic or renal dysfunction: CALGB 60301. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 27: 1800-5. PMID 19255312 DOI: 10.1200/Jco.2008.20.0931  0.205
2002 Kang J, Kumar V, Yang D, Chowdhury PR, Hohl RJ. Cyclodextrin complexation: influence on the solubility, stability, and cytotoxicity of camptothecin, an antineoplastic agent. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 15: 163-70. PMID 11849913 DOI: 10.1016/S0928-0987(01)00214-7  0.198
2003 Vanapalli SR, Chen Y, Ellingrod VL, Kitzman D, Lee Y, Hohl RJ, Fleckenstein L. Orange juice decreases the oral bioavailability of ivermectin in healthy volunteers. Clinical Pharmacology & Therapeutics. 73: P94-P94. DOI: 10.1016/S0009-9236(03)90702-8  0.198
2006 Magalhaes-Silverma M, Leopold C, Cater T, Hohl R, Gingrich R. Pre-Transplant Smoking and Transplant-Related Mortality from Pulmonary Causes in Recipients of Allogeneic Stem Cell Transplants. Blood. 108: 5342-5342. DOI: 10.1182/Blood.V108.11.5342.5342  0.193
2007 Hohl RJ. Clinical pharmacology: Bridging discovery and practice Clinical Pharmacology and Therapeutics. 81: 783-785. PMID 17505487 DOI: 10.1038/Sj.Clpt.6100225  0.192
2015 Hohl RJ. Oncology trial design: More accurately and efficiently advancing the field Clinical Pharmacology and Therapeutics. 97: 430-432. PMID 25684240 DOI: 10.1002/Cpt.94  0.188
2009 Holstein SA, Hohl RJ. Vascular medicine: A look forward Clinical Pharmacology and Therapeutics. 86: 117-119. PMID 19621001 DOI: 10.1038/Clpt.2009.125  0.18
1996 Peters C, Miller J, Abel SL, McMillan SK, Getchell JP, Giller RH, Hohl RJ, De Alarcon PA. Iowa newborn hemoglobinopathy screening and comprehensive care: A model for rural states [1] Journal of Pediatric Hematology/Oncology. 18: 416-418. PMID 8888756 DOI: 10.1097/00043426-199611000-00018  0.178
2021 Weissenrieder JS, Reed JL, Moldovan GL, Johnson MT, Trebak M, Neighbors JD, Mailman RB, Hohl RJ. Antipsychotic drugs elicit cytotoxicity in glioblastoma multiforme in a calcium-dependent, non-D receptor-dependent, manner. Pharmacology Research & Perspectives. 9: e00689. PMID 34003586 DOI: 10.1002/prp2.689  0.169
1991 Hohl RJ, Kennedy EJ, Frischer H. Defenses against oxidation in human erythrocytes: role of glutathione reductase in the activation of glucose decarboxylation by hemolytic drugs. The Journal of Laboratory and Clinical Medicine. 117: 325-31. PMID 1901343  0.149
2001 Chapel S, Veng-Pedersen P, Hohl RJ, Schmidt RL, Mcguire EM, Widness JA. Changes in erythropoietin pharmacokinetics following busulfan-induced bone marrow ablation in sheep: Evidence for bone marrow as a major erythropoietin elimination pathway Journal of Pharmacology and Experimental Therapeutics. 298: 820-824. PMID 11454947  0.132
2004 Veng-Pedersen P, Chapel S, Al-Huniti NH, Schimdt RL, Sedars EM, Hohl RJ, Widness JA. Pharmacokinetic tracer kinetics analysis of changes in erythropoietin receptor population in phylebotomy-induced anemia and bone marrow ablation Biopharmaceutics and Drug Disposition. 25: 149-156. PMID 15108217 DOI: 10.1002/bdd.395  0.128
2022 Zhao C, Bartock M, Jia B, Shah N, Claxton DF, Wirk B, Rakszawski KL, Nickolich MS, Naik SG, Rybka WB, Ehmann WCC, Hohl RJ, Valentin J, Bernas-Peterson M, Gerber EM, et al. Post-transplant cyclophosphamide alters immune signatures and leads to impaired T cell reconstitution in allogeneic hematopoietic stem cell transplant. Journal of Hematology & Oncology. 15: 64. PMID 35590334 DOI: 10.1186/s13045-022-01287-3  0.125
1999 Burns CP, Halabi S, Clamon GH, Hars V, Wagner BA, Hohl RJ, Lester E, Kirshner JJ, Vinciguerra V, Paskett E. Phase I clinical study of fish oil fatty acid capsules for patients with cancer cachexia: Cancer and leukemia group B study 9473 Clinical Cancer Research. 5: 3942-3947. PMID 10632323  0.122
2022 Shah N, Cioccio J, Rakszawski K, Zheng H, Nickolich M, Naik S, Wirk B, Rybka W, Ehmann C, Silar B, Vajdic C, Mierski J, Zhou S, Shike H, Greiner R, ... ... Hohl R, et al. Low-dose total body irradiation promotes T-cells donor chimerism in reduced-intensity/non-myeloablative allogeneic stem cell transplant with post-transplant cyclophosphamide. Leukemia Research. 123: 106969. PMID 36306723 DOI: 10.1016/j.leukres.2022.106969  0.106
2000 Choon-Kee L, De Magalhaes-Silverman M, Hohl RJ, Hayashi M, Schlueter A, Gingrich RD. A phase-I, dose escalation study for salvage chemotherapy for patients with refractory lymphoma, prior to myeloablative therapy with stem cell transplantation Blood. 96.  0.104
2003 Lee CK, de Magalhaes-Silverman M, Hohl RJ, Hayashi M, Buatti J, Wen BC, Schlueter A, Strauss RG, Gingrich RD. Donor T-lymphocyte infusion for unrelated allogeneic bone marrow transplantation with CD3+ T-cell-depleted graft Bone Marrow Transplantation. 31: 121-128. PMID 12621494 DOI: 10.1038/sj.bmt.1703803  0.102
2024 Guare EG, Hale CM, Sivik J, Lehman E, Inoue Y, Rakszawski K, Songdej N, Nickolich M, Zheng H, Naik S, Claxton D, Rybka W, Hohl R, Mineishi S, Minagawa K, et al. The addition of doxycycline to fluoroquinolones for bacterial prophylaxis in autologous stem cell transplantation for multiple myeloma. Transplant Infectious Disease : An Official Journal of the Transplantation Society. e14241. PMID 38269469 DOI: 10.1111/tid.14241  0.097
2022 Cioccio J, Rakszawski K, Zheng H, Nickolich M, Naik S, Wirk B, Rybka W, Ehmann C, Silar B, Vajdic C, Shah N, Tuanquin L, Greiner R, Brown V, Hohl R, et al. Donor HLA mismatch promotes full donor T-cell chimerism in the allogeneic stem cell transplant with reduced-intensity conditioning and post-transplant cyclophosphamide GVHD prophylaxis. Annals of Hematology. PMID 36527460 DOI: 10.1007/s00277-022-05077-2  0.094
2015 Holstein SA, Bigelow JC, Olson RD, Vestal RE, Walsh GM, Hohl RJ. Phase I and pharmacokinetic study of the novel anthracycline derivative 5-imino-13-deoxydoxorubicin (GPX-150) in patients with advanced solid tumors Investigational New Drugs. DOI: 10.1007/s10637-015-0220-z  0.09
2020 Zheng H, Mineishi S, Claxton D, Zhu J, Zhao C, Jia B, Ehmann WC, Rybka WB, Naik S, Songdej N, Drabick JJ, Hohl RJ. A Phase I Clinical Trial of Avelumab in Combination with Decitabine as First Line Treatment of Unfit patients with AML. American Journal of Hematology. PMID 33146922 DOI: 10.1002/ajh.26043  0.082
1995 Lee CK, Gingrich RD, Hohl RJ, Ajram KA. Engraftment syndrome in autologous bone marrow and peripheral stem cell transplantation Bone Marrow Transplantation. 16: 175-182. PMID 7581119  0.08
1996 Lee CK, Harman GS, Hohl RJ, Gingrich RD. Fatal cyclophosphamide cardiomyopathy: its clinical course and treatment. Bone Marrow Transplantation. 18: 573-7. PMID 8879620  0.075
2000 Lee CK, Hohl RJ, Masaki H, Schlueter A, Field E, Gingrich RD. Allogeneic hematopoietic stem cell (hsct) in patients with advanced hematological diseases using a non-myeloablative conditioning regimen Blood. 96.  0.073
2004 Burns CP, Halabi S, Clamon G, Kaplan E, Hohl RJ, Atkins JN, Schwartz MA, Wagner BA, Paskett E. Phase II study of high-dose fish oil capsules for patients with cancer-related cachexia. Cancer. 101: 370-8. PMID 15241836 DOI: 10.1002/cncr.20362  0.068
2005 Xing D, Hohl RJ, Martins JB. 71 LOVASTATIN IS ANTIARRHYTHMIC IN ISCHEMIC HEART TISSUE BY BLOCKING TRIGGERED ACTIVITY Journal of Investigative Medicine. 53: S368.5-S368. DOI: 10.2310/6650.2005.00206.70  0.067
2000 Lee CK, Hohl RJ, Schlueter A, Hayashi M, Field E, Gingrich RD. Fudarabine/cyclophosphamide followed by allogeneic peripheral blood transplantation (pbct) for older patients with advanced hematological disorders Blood. 96.  0.03
1980 Beiderbeck R, Hohl R. Die Wirkung zeitlich begrenzter Phytohormongaben auf isolierte Mesophyllzellen von Calystegia sepium L. Biochemie Und Physiologie Der Pflanzen. 175: 45-49. DOI: 10.1016/S0015-3796(80)80089-8  0.01
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