Clay F. Semenkovich - Publications

Affiliations: 
Biology & Biomedical Sciences (Molecular Cell Biology) Washington University, Saint Louis, St. Louis, MO 
Area:
General Biology, Medicine and Surgery, Molecular Biology

143 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Semenkovich CF. Insulin Resistance and a Long, Strange Trip. The New England Journal of Medicine. PMID 26886417 DOI: 10.1056/NEJMe1600962  0.72
2015 Funai K, Lodhi IJ, Spears LD, Yin L, Song H, Klein S, Semenkovich CF. Skeletal Muscle Phospholipid Metabolism Regulates Insulin Sensitivity and Contractile Function. Diabetes. PMID 26512026 DOI: 10.2337/db15-0659  0.72
2015 Izawa T, Rohatgi N, Fukunaga T, Wang QT, Silva MJ, Gardner MJ, McDaniel ML, Abumrad NA, Semenkovich CF, Teitelbaum SL, Zou W. ASXL2 Regulates Glucose, Lipid, and Skeletal Homeostasis. Cell Reports. 11: 1625-37. PMID 26051940 DOI: 10.1016/j.celrep.2015.05.019  0.72
2015 Lodhi IJ, Wei X, Yin L, Feng C, Adak S, Abou-Ezzi G, Hsu FF, Link DC, Semenkovich CF. Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability. Cell Metabolism. 21: 51-64. PMID 25565205 DOI: 10.1016/j.cmet.2014.12.002  0.72
2014 Lu S, Kanekura K, Hara T, Mahadevan J, Spears LD, Oslowski CM, Martinez R, Yamazaki-Inoue M, Toyoda M, Neilson A, Blanner P, Brown CM, Semenkovich CF, Marshall BA, Hershey T, et al. A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome. Proceedings of the National Academy of Sciences of the United States of America. 111: E5292-301. PMID 25422446 DOI: 10.1073/pnas.1421055111  0.72
2014 Hsu FF, Lodhi IJ, Turk J, Semenkovich CF. Structural distinction of diacyl-, alkylacyl, and alk-1-enylacyl glycerophosphocholines as [M - 15]⁻ ions by multiple-stage linear ion-trap mass spectrometry with electrospray ionization. Journal of the American Society For Mass Spectrometry. 25: 1412-20. PMID 24781459 DOI: 10.1007/s13361-014-0908-x  0.72
2014 Lodhi IJ, Semenkovich CF. Peroxisomes: a nexus for lipid metabolism and cellular signaling. Cell Metabolism. 19: 380-92. PMID 24508507 DOI: 10.1016/j.cmet.2014.01.002  0.72
2014 Partridge CG, Fawcett GL, Wang B, Semenkovich CF, Cheverud JM. The effect of dietary fat intake on hepatic gene expression in LG/J AND SM/J mice. Bmc Genomics. 15: 99. PMID 24499025 DOI: 10.1186/1471-2164-15-99  0.72
2014 Wei X, Song H, Semenkovich CF. Insulin-regulated protein palmitoylation impacts endothelial cell function. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 346-54. PMID 24357059 DOI: 10.1161/ATVBAHA.113.302848  0.72
2014 Rajagopal R, Semenkovich CF. Peroxisome proliferator activated receptor-δ: the middle child vies for attention. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 5-7. PMID 24335675 DOI: 10.1161/ATVBAHA.113.302777  0.72
2013 Spears LD, Razani B, Semenkovich CF. Interleukins and atherosclerosis: a dysfunctional family grows. Cell Metabolism. 18: 614-6. PMID 24206661 DOI: 10.1016/j.cmet.2013.10.009  0.72
2013 Ridaura VK, Faith JJ, Rey FE, Cheng J, Duncan AE, Kau AL, Griffin NW, Lombard V, Henrissat B, Bain JR, Muehlbauer MJ, Ilkayeva O, Semenkovich CF, Funai K, Hayashi DK, et al. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science (New York, N.Y.). 341: 1241214. PMID 24009397 DOI: 10.1126/science.1241214  0.72
2013 Jensen-Urstad AP, Song H, Lodhi IJ, Funai K, Yin L, Coleman T, Semenkovich CF. Nutrient-dependent phosphorylation channels lipid synthesis to regulate PPARα. Journal of Lipid Research. 54: 1848-59. PMID 23585690 DOI: 10.1194/jlr.M036103  0.72
2013 Funai K, Song H, Yin L, Lodhi IJ, Wei X, Yoshino J, Coleman T, Semenkovich CF. Muscle lipogenesis balances insulin sensitivity and strength through calcium signaling. The Journal of Clinical Investigation. 123: 1229-40. PMID 23376793 DOI: 10.1172/JCI65726  0.72
2013 Knobloch M, Braun SM, Zurkirchen L, von Schoultz C, Zamboni N, Araúzo-Bravo MJ, Kovacs WJ, Karalay O, Suter U, Machado RA, Roccio M, Lutolf MP, Semenkovich CF, Jessberger S. Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis. Nature. 493: 226-30. PMID 23201681 DOI: 10.1038/nature11689  0.72
2012 Minkina O, Cheverud JM, Fawcett G, Semenkovich CF, Kenney-Hunt JP. Quantitative trait loci affecting liver fat content in mice. G3 (Bethesda, Md.). 2: 1019-25. PMID 22973538 DOI: 10.1534/g3.112.003343  0.72
2012 Lodhi IJ, Yin L, Jensen-Urstad AP, Funai K, Coleman T, Baird JH, El Ramahi MK, Razani B, Song H, Fu-Hsu F, Turk J, Semenkovich CF. Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARγ activation to decrease diet-induced obesity. Cell Metabolism. 16: 189-201. PMID 22863804 DOI: 10.1016/j.cmet.2012.06.013  0.72
2012 Lei Y, Wen H, Yu Y, Taxman DJ, Zhang L, Widman DG, Swanson KV, Wen KW, Damania B, Moore CB, Giguère PM, Siderovski DP, Hiscott J, Razani B, Semenkovich CF, et al. The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy. Immunity. 36: 933-46. PMID 22749352 DOI: 10.1016/j.immuni.2012.03.025  0.72
2012 Razani B, Feng C, Coleman T, Emanuel R, Wen H, Hwang S, Ting JP, Virgin HW, Kastan MB, Semenkovich CF. Autophagy links inflammasomes to atherosclerotic progression. Cell Metabolism. 15: 534-44. PMID 22440612 DOI: 10.1016/j.cmet.2012.02.011  0.72
2012 Wei X, Yang Z, Rey FE, Ridaura VK, Davidson NO, Gordon JI, Semenkovich CF. Fatty acid synthase modulates intestinal barrier function through palmitoylation of mucin 2. Cell Host & Microbe. 11: 140-52. PMID 22341463 DOI: 10.1016/j.chom.2011.12.006  0.72
2012 Jensen-Urstad AP, Semenkovich CF. Fatty acid synthase and liver triglyceride metabolism: housekeeper or messenger? Biochimica Et Biophysica Acta. 1821: 747-53. PMID 22009142 DOI: 10.1016/j.bbalip.2011.09.017  0.72
2011 Lawson HA, Cady JE, Partridge C, Wolf JB, Semenkovich CF, Cheverud JM. Genetic effects at pleiotropic loci are context-dependent with consequences for the maintenance of genetic variation in populations. Plos Genetics. 7: e1002256. PMID 21931559 DOI: 10.1371/journal.pgen.1002256  0.72
2011 Razani B, Zhang H, Schulze PC, Schilling JD, Verbsky J, Lodhi IJ, Topkara VK, Feng C, Coleman T, Kovacs A, Kelly DP, Saffitz JE, Dorn GW, Nichols CG, Semenkovich CF. Fatty acid synthase modulates homeostatic responses to myocardial stress. The Journal of Biological Chemistry. 286: 30949-61. PMID 21757749 DOI: 10.1074/jbc.M111.230508  0.72
2011 Johnson M, Semenkovich CF. Common sense treatment for common lipid disorders. Missouri Medicine. 108: 107-12. PMID 21568232  0.72
2011 Semenkovich CF. Endocrinology in 2011: new options for intractable problems. Missouri Medicine. 108: 90-1. PMID 21568228  0.72
2011 Funai K, Semenkovich CF. Skeletal muscle lipid flux: running water carries no poison. American Journal of Physiology. Endocrinology and Metabolism. 301: E245-51. PMID 21558546 DOI: 10.1152/ajpendo.00152.2011  0.72
2011 Lawson HA, Lee A, Fawcett GL, Wang B, Pletscher LS, Maxwell TJ, Ehrich TH, Kenney-Hunt JP, Wolf JB, Semenkovich CF, Cheverud JM. The importance of context to the genetic architecture of diabetes-related traits is revealed in a genome-wide scan of a LG/J × SM/J murine model. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 22: 197-208. PMID 21210123 DOI: 10.1007/s00335-010-9313-3  0.72
2011 Wei X, Schneider JG, Shenouda SM, Lee A, Towler DA, Chakravarthy MV, Vita JA, Semenkovich CF. De novo lipogenesis maintains vascular homeostasis through endothelial nitric-oxide synthase (eNOS) palmitoylation. The Journal of Biological Chemistry. 286: 2933-45. PMID 21098489 DOI: 10.1074/jbc.M110.193037  0.72
2011 Lodhi IJ, Wei X, Semenkovich CF. Lipoexpediency: de novo lipogenesis as a metabolic signal transmitter. Trends in Endocrinology and Metabolism: Tem. 22: 1-8. PMID 20889351 DOI: 10.1016/j.tem.2010.09.002  0.72
2011 Cheverud JM, Lawson HA, Fawcett GL, Wang B, Pletscher LS, R Fox A, Maxwell TJ, Ehrich TH, Kenney-Hunt JP, Wolf JB, Semenkovich CF. Diet-dependent genetic and genomic imprinting effects on obesity in mice. Obesity (Silver Spring, Md.). 19: 160-70. PMID 20539295 DOI: 10.1038/oby.2010.141  0.72
2011 Semenkovich CF. Disorders of Lipid Metabolism Goldman's Cecil Medicine: Twenty Fourth Edition. 2: 1346-1353. DOI: 10.1016/B978-1-4377-1604-7.00213-X  0.72
2010 Yu C, Jiang S, Lu J, Coughlin CC, Wang Y, Swietlicki EA, Wang L, Vietor I, Huber LA, Cikes D, Coleman T, Xie Y, Semenkovich CF, Davidson NO, Levin MS, et al. Deletion of Tis7 protects mice from high-fat diet-induced weight gain and blunts the intestinal adaptive response postresection. The Journal of Nutrition. 140: 1907-14. PMID 20861213 DOI: 10.3945/jn.110.127084  0.72
2010 Lawson HA, Zelle KM, Fawcett GL, Wang B, Pletscher LS, Maxwell TJ, Ehrich TH, Kenney-Hunt JP, Wolf JB, Semenkovich CF, Cheverud JM. Genetic, epigenetic, and gene-by-diet interaction effects underlie variation in serum lipids in a LG/JxSM/J murine model. Journal of Lipid Research. 51: 2976-84. PMID 20601649 DOI: 10.1194/jlr.M006957  0.72
2010 Schneider JG, Yang Z, Chakravarthy MV, Lodhi IJ, Wei X, Turk J, Semenkovich CF. Macrophage fatty-acid synthase deficiency decreases diet-induced atherosclerosis. The Journal of Biological Chemistry. 285: 23398-409. PMID 20479009 DOI: 10.1074/jbc.M110.100321  0.72
2010 Cheverud JM, Fawcett GL, Jarvis JP, Norgard EA, Pavlicev M, Pletscher LS, Polonsky KS, Ye H, Bell GI, Semenkovich CF. Calpain-10 is a component of the obesity-related quantitative trait locus Adip1. Journal of Lipid Research. 51: 907-13. PMID 20388922 DOI: 10.1194/jlr.M900128  0.72
2010 Razani B, Feng C, Semenkovich CF. p53 is required for chloroquine-induced atheroprotection but not insulin sensitization. Journal of Lipid Research. 51: 1738-46. PMID 20208057 DOI: 10.1194/jlr.M003681  0.72
2010 Song H, Wohltmann M, Bao S, Ladenson JH, Semenkovich CF, Turk J. Mice deficient in group VIB phospholipase A2 (iPLA2gamma) exhibit relative resistance to obesity and metabolic abnormalities induced by a Western diet. American Journal of Physiology. Endocrinology and Metabolism. 298: E1097-114. PMID 20179248 DOI: 10.1152/ajpendo.00780.2009  0.72
2009 Chakravarthy MV, Lodhi IJ, Yin L, Malapaka RR, Xu HE, Turk J, Semenkovich CF. Identification of a physiologically relevant endogenous ligand for PPARalpha in liver. Cell. 138: 476-88. PMID 19646743 DOI: 10.1016/j.cell.2009.05.036  0.72
2009 Razani B, Semenkovich CF. Getting away from glucose: stop sugarcoating diabetes. Nature Medicine. 15: 372-3. PMID 19350008 DOI: 10.1038/nm0409-372  0.72
2009 Lodhi IJ, Semenkovich CF. Why we should put clothes on mice. Cell Metabolism. 9: 111-2. PMID 19187768 DOI: 10.1016/j.cmet.2009.01.004  0.72
2009 Chakravarthy MV, Zhu Y, Yin L, Coleman T, Pappan KL, Marshall CA, McDaniel ML, Semenkovich CF. Inactivation of hypothalamic FAS protects mice from diet-induced obesity and inflammation. Journal of Lipid Research. 50: 630-40. PMID 19029118 DOI: 10.1194/jlr.M800379-JLR200  0.72
2008 Razani B, Chakravarthy MV, Semenkovich CF. Insulin resistance and atherosclerosis. Endocrinology and Metabolism Clinics of North America. 37: 603-21, viii. PMID 18775354 DOI: 10.1016/j.ecl.2008.05.001  0.72
2008 Newberry EP, Kennedy SM, Xie Y, Luo J, Stanley SE, Semenkovich CF, Crooke RM, Graham MJ, Davidson NO. Altered hepatic triglyceride content after partial hepatectomy without impaired liver regeneration in multiple murine genetic models. Hepatology (Baltimore, Md.). 48: 1097-105. PMID 18697204 DOI: 10.1002/hep.22473  0.72
2008 Proctor BM, Jin X, Lupu TS, Muglia LJ, Semenkovich CF, Muslin AJ. Requirement for p38 mitogen-activated protein kinase activity in neointima formation after vascular injury. Circulation. 118: 658-66. PMID 18645058 DOI: 10.1161/CIRCULATIONAHA.107.734848  0.72
2008 Chakravarthy MV, Zhu Y, Wice MB, Coleman T, Pappan KL, Marshall CA, McDaniel ML, Semenkovich CF. Decreased fetal size is associated with beta-cell hyperfunction in early life and failure with age. Diabetes. 57: 2698-707. PMID 18591393 DOI: 10.2337/db08-0404  0.72
2008 Zhang JR, Coleman T, Langmade SJ, Scherrer DE, Lane L, Lanier MH, Feng C, Sands MS, Schaffer JE, Semenkovich CF, Ory DS. Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking. The Journal of Clinical Investigation. 118: 2281-90. PMID 18483620 DOI: 10.1172/JCI32561  0.72
2007 Gates AC, Bernal-Mizrachi C, Chinault SL, Feng C, Schneider JG, Coleman T, Malone JP, Townsend RR, Chakravarthy MV, Semenkovich CF. Respiratory uncoupling in skeletal muscle delays death and diminishes age-related disease. Cell Metabolism. 6: 497-505. PMID 18054318 DOI: 10.1016/j.cmet.2007.10.010  0.72
2007 Schneider JG, Zhu Y, Coleman T, Semenkovich CF. Macrophage beta3 integrin suppresses hyperlipidemia-induced inflammation by modulating TNFalpha expression. Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 2699-706. PMID 17951320 DOI: 10.1161/ATVBAHA.107.153650  0.72
2007 Woloszynek JC, Coleman T, Semenkovich CF, Sands MS. Lysosomal dysfunction results in altered energy balance. The Journal of Biological Chemistry. 282: 35765-71. PMID 17911106 DOI: 10.1074/jbc.M705124200  0.72
2007 Tordjman KM, Semenkovich CF, Coleman T, Yudovich R, Bak S, Osher E, Vechoropoulos M, Stern N. Absence of peroxisome proliferator-activated receptor-alpha abolishes hypertension and attenuates atherosclerosis in the Tsukuba hypertensive mouse. Hypertension. 50: 945-51. PMID 17909121 DOI: 10.1161/HYPERTENSIONAHA.107.094268  0.72
2007 Gustafsson M, Levin M, Skålén K, Perman J, Fridén V, Jirholt P, Olofsson SO, Fazio S, Linton MF, Semenkovich CF, Olivecrona G, Borén J. Retention of low-density lipoprotein in atherosclerotic lesions of the mouse: evidence for a role of lipoprotein lipase. Circulation Research. 101: 777-83. PMID 17761930 DOI: 10.1161/CIRCRESAHA.107.149666  0.72
2007 Babaev VR, Ishiguro H, Ding L, Yancey PG, Dove DE, Kovacs WJ, Semenkovich CF, Fazio S, Linton MF. Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation. 116: 1404-12. PMID 17724261 DOI: 10.1161/CIRCULATIONAHA.106.684704  0.72
2007 Chakravarthy MV, Zhu Y, López M, Yin L, Wozniak DF, Coleman T, Hu Z, Wolfgang M, Vidal-Puig A, Lane MD, Semenkovich CF. Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis. The Journal of Clinical Investigation. 117: 2539-52. PMID 17694178 DOI: 10.1172/JCI31183  0.72
2007 Semenkovich CF, Teitelbaum SL. Bone weighs in on obesity. Cell. 130: 409-11. PMID 17693252 DOI: 10.1016/j.cell.2007.07.031  0.72
2007 Bao S, Li Y, Lei X, Wohltmann M, Jin W, Bohrer A, Semenkovich CF, Ramanadham S, Tabas I, Turk J. Attenuated free cholesterol loading-induced apoptosis but preserved phospholipid composition of peritoneal macrophages from mice that do not express group VIA phospholipase A2. The Journal of Biological Chemistry. 282: 27100-14. PMID 17627946 DOI: 10.1074/jbc.M701316200  0.72
2007 Proctor BM, Ren J, Chen Z, Schneider JG, Coleman T, Lupu TS, Semenkovich CF, Muslin AJ. Grb2 is required for atherosclerotic lesion formation. Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 1361-7. PMID 17363695 DOI: 10.1161/ATVBAHA.106.134007  0.72
2007 Chakravarthy MV, Semenkovich CF. The ABCs of beta-cell dysfunction in type 2 diabetes. Nature Medicine. 13: 241-2. PMID 17342111 DOI: 10.1038/nm0307-241  0.72
2007 Bernal-Mizrachi C, Xiaozhong L, Yin L, Knutsen RH, Howard MJ, Arends JJ, Desantis P, Coleman T, Semenkovich CF. An afferent vagal nerve pathway links hepatic PPARalpha activation to glucocorticoid-induced insulin resistance and hypertension. Cell Metabolism. 5: 91-102. PMID 17276352 DOI: 10.1016/j.cmet.2006.12.010  0.72
2007 Bäckhed F, Manchester JK, Semenkovich CF, Gordon JI. Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proceedings of the National Academy of Sciences of the United States of America. 104: 979-84. PMID 17210919 DOI: 10.1073/pnas.0605374104  0.72
2006 Schneider JG, Finck BN, Ren J, Standley KN, Takagi M, Maclean KH, Bernal-Mizrachi C, Muslin AJ, Kastan MB, Semenkovich CF. ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. Cell Metabolism. 4: 377-89. PMID 17084711 DOI: 10.1016/j.cmet.2006.10.002  0.72
2006 Subramanian S, DeRosa MA, Bernal-Mizrachi C, Laffely N, Cade WT, Yarasheski KE, Cryer PE, Semenkovich CF. PPARalpha activation elevates blood pressure and does not correct glucocorticoid-induced insulin resistance in humans. American Journal of Physiology. Endocrinology and Metabolism. 291: E1365-71. PMID 16868225 DOI: 10.1152/ajpendo.00230.2006  0.72
2006 Semenkovich CF. Insulin resistance and atherosclerosis. The Journal of Clinical Investigation. 116: 1813-22. PMID 16823479 DOI: 10.1172/JCI29024  0.72
2006 Bernal-Mizrachi C, Semenkovich CF. Fast predators or fast food, the fit still survive. Nature Medicine. 12: 46-7; discussion 47. PMID 16397564 DOI: 10.1038/nm0106-46  0.72
2005 Schneider JG, Semenkovich CF. PPARalpha: savior or savage? Cell Metabolism. 2: 341-2. PMID 16330317 DOI: 10.1016/j.cmet.2005.11.006  0.72
2005 Wang Y, Iordanov H, Swietlicki EA, Wang L, Fritsch C, Coleman T, Semenkovich CF, Levin MS, Rubin DC. Targeted intestinal overexpression of the immediate early gene tis7 in transgenic mice increases triglyceride absorption and adiposity. The Journal of Biological Chemistry. 280: 34764-75. PMID 16085642 DOI: 10.1074/jbc.M507058200  0.72
2005 Semenkovich CF. TZDs and diabetes: testing the waters. Nature Medicine. 11: 822-4. PMID 16079871 DOI: 10.1038/nm0805-822  0.72
2005 Chakravarthy MV, Pan Z, Zhu Y, Tordjman K, Schneider JG, Coleman T, Turk J, Semenkovich CF. "New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis. Cell Metabolism. 1: 309-22. PMID 16054078 DOI: 10.1016/j.cmet.2005.04.002  0.72
2005 Finck BN, Bernal-Mizrachi C, Han DH, Coleman T, Sambandam N, LaRiviere LL, Holloszy JO, Semenkovich CF, Kelly DP. A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes. Cell Metabolism. 1: 133-44. PMID 16054054 DOI: 10.1016/j.cmet.2005.01.006  0.72
2005 Ehrich TH, Hrbek T, Kenney-Hunt JP, Pletscher LS, Wang B, Semenkovich CF, Cheverud JM. Fine-mapping gene-by-diet interactions on chromosome 13 in a LG/J x SM/J murine model of obesity. Diabetes. 54: 1863-72. PMID 15919810 DOI: 10.2337/diabetes.54.6.1863  0.72
2005 Bernal-Mizrachi C, Gates AC, Weng S, Imamura T, Knutsen RH, DeSantis P, Coleman T, Townsend RR, Muglia LJ, Semenkovich CF. Vascular respiratory uncoupling increases blood pressure and atherosclerosis. Nature. 435: 502-6. PMID 15917810 DOI: 10.1038/nature03527  0.72
2005 Jarvis JP, Kenney-Hunt J, Ehrich TH, Pletscher LS, Semenkovich CF, Cheverud JM. Maternal genotype affects adult offspring lipid, obesity, and diabetes phenotypes in LGXSM recombinant inbred strains. Journal of Lipid Research. 46: 1692-702. PMID 15897602 DOI: 10.1194/jlr.M500073-JLR200  0.72
2005 Chaparro J, Reeds DN, Wen W, Xueping E, Klein S, Semenkovich CF, Bae KT, Quirk EK, Powderly WG, Yarasheski KE, Li E. Alterations in thigh subcutaneous adipose tissue gene expression in protease inhibitor-based highly active antiretroviral therapy. Metabolism: Clinical and Experimental. 54: 561-7. PMID 15877283 DOI: 10.1016/j.metabol.2004.08.022  0.72
2005 Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, Courtois M, Wozniak DF, Sambandam N, Bernal-Mizrachi C, Chen Z, Holloszy JO, Medeiros DM, Schmidt RE, Saffitz JE, ... ... Semenkovich CF, et al. PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. Plos Biology. 3: e101. PMID 15760270 DOI: 10.1371/journal.pbio.0030101  0.72
2005 Pappan KL, Pan Z, Kwon G, Marshall CA, Coleman T, Goldberg IJ, McDaniel ML, Semenkovich CF. Pancreatic beta-cell lipoprotein lipase independently regulates islet glucose metabolism and normal insulin secretion. The Journal of Biological Chemistry. 280: 9023-9. PMID 15637076 DOI: 10.1074/jbc.M409706200  0.72
2004 Cheverud JM, Ehrich TH, Hrbek T, Kenney JP, Pletscher LS, Semenkovich CF. Quantitative trait loci for obesity- and diabetes-related traits and their dietary responses to high-fat feeding in LGXSM recombinant inbred mouse strains. Diabetes. 53: 3328-36. PMID 15561968 DOI: 10.2337/diabetes.53.12.3328  0.72
2004 Bäckhed F, Ding H, Wang T, Hooper LV, Koh GY, Nagy A, Semenkovich CF, Gordon JI. The gut microbiota as an environmental factor that regulates fat storage. Proceedings of the National Academy of Sciences of the United States of America. 101: 15718-23. PMID 15505215 DOI: 10.1073/pnas.0407076101  0.72
2004 Cheverud JM, Ehrich TH, Kenney JP, Pletscher LS, Semenkovich CF. Genetic evidence for discordance between obesity- and diabetes-related traits in the LGXSM recombinant inbred mouse strains. Diabetes. 53: 2700-8. PMID 15448104 DOI: 10.2337/diabetes.53.10.2700  0.72
2004 Semenkovich CF. Fatty acid metabolism and vascular disease. Trends in Cardiovascular Medicine. 14: 72-6. PMID 15030793 DOI: 10.1016/j.tcm.2003.12.004  0.72
2004 Woloszynek JC, Roberts M, Coleman T, Vogler C, Sly W, Semenkovich CF, Sands MS. Numerous transcriptional alterations in liver persist after short-term enzyme-replacement therapy in a murine model of mucopolysaccharidosis type VII. The Biochemical Journal. 379: 461-9. PMID 14705966 DOI: 10.1042/BJ20031048  0.72
2004 Nesto RW, Bell D, Bonow RO, Fonseca V, Grundy SM, Horton ES, Le Winter M, Porte D, Semenkovich CF, Smith S, Young LH, Kahn R. Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association. Diabetes Care. 27: 256-63. PMID 14693998 DOI: 10.2337/diacare.27.1.256  0.72
2004 Han DH, Nolte LA, Ju JS, Coleman T, Holloszy JO, Semenkovich CF. UCP-mediated energy depletion in skeletal muscle increases glucose transport despite lipid accumulation and mitochondrial dysfunction. American Journal of Physiology. Endocrinology and Metabolism. 286: E347-53. PMID 14613927 DOI: 10.1152/ajpendo.00434.2003  0.72
2003 Nesto RW, Bell D, Bonow RO, Fonseca V, Grundy SM, Horton ES, Le Winter M, Porte D, Semenkovich CF, Smith S, Young LH, Kahn R. Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association. October 7, 2003. Circulation. 108: 2941-8. PMID 14662691 DOI: 10.1161/01.CIR.0000103683.99399.7E  0.72
2003 Grenache DG, Coleman T, Semenkovich CF, Santoro SA, Zutter MM. Alpha2beta1 integrin and development of atherosclerosis in a mouse model: assessment of risk. Arteriosclerosis, Thrombosis, and Vascular Biology. 23: 2104-9. PMID 14512368 DOI: 10.1161/01.ATV.0000097282.22923.EF  0.72
2003 Baar K, Song Z, Semenkovich CF, Jones TE, Han DH, Nolte LA, Ojuka EO, Chen M, Holloszy JO. Skeletal muscle overexpression of nuclear respiratory factor 1 increases glucose transport capacity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 1666-73. PMID 12958173 DOI: 10.1096/fj.03-0049com  0.72
2003 Bernal-Mizrachi C, Weng S, Feng C, Finck BN, Knutsen RH, Leone TC, Coleman T, Mecham RP, Kelly DP, Semenkovich CF. Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice. Nature Medicine. 9: 1069-75. PMID 12847522 DOI: 10.1038/nm898  0.72
2003 Yarasheski KE, Tebas P, Claxton S, Marin D, Coleman T, Powderly WG, Semenkovich CF. Visceral adiposity, C-peptide levels, and low lipase activities predict HIV-dyslipidemia. American Journal of Physiology. Endocrinology and Metabolism. 285: E899-905. PMID 12837664 DOI: 10.1152/ajpendo.00036.2003  0.72
2003 Hensley LL, Ranganathan G, Wagner EM, Wells BD, Daniel JC, Vu D, Semenkovich CF, Zechner R, Kern PA. Transgenic mice expressing lipoprotein lipase in adipose tissue. Absence of the proximal 3'-untranslated region causes translational upregulation. The Journal of Biological Chemistry. 278: 32702-9. PMID 12796491 DOI: 10.1074/jbc.M304200200  0.72
2003 Weng S, Zemany L, Standley KN, Novack DV, La Regina M, Bernal-Mizrachi C, Coleman T, Semenkovich CF. Beta3 integrin deficiency promotes atherosclerosis and pulmonary inflammation in high-fat-fed, hyperlipidemic mice. Proceedings of the National Academy of Sciences of the United States of America. 100: 6730-5. PMID 12746502 DOI: 10.1073/pnas.1137612100  0.72
2003 Chen Z, Fitzgerald RL, Saffitz JE, Semenkovich CF, Schonfeld G. Amino terminal 38.9% of apolipoprotein B-100 is sufficient to support cholesterol-rich lipoprotein production and atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 23: 668-74. PMID 12615667 DOI: 10.1161/01.ATV.0000062701.02853.AE  0.72
2002 Bidder M, Shao JS, Charlton-Kachigian N, Loewy AP, Semenkovich CF, Towler DA. Osteopontin transcription in aortic vascular smooth muscle cells is controlled by glucose-regulated upstream stimulatory factor and activator protein-1 activities. The Journal of Biological Chemistry. 277: 44485-96. PMID 12200434 DOI: 10.1074/jbc.M206235200  0.72
2002 Bernal-Mizrachi C, Weng S, Li B, Nolte LA, Feng C, Coleman T, Holloszy JO, Semenkovich CF. Respiratory uncoupling lowers blood pressure through a leptin-dependent mechanism in genetically obese mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 22: 961-8. PMID 12067905 DOI: 10.1161/01.ATV.0000019404.65403.71  0.72
2002 Tordjman K, Standley KN, Bernal-Mizrachi C, Leone TC, Coleman T, Kelly DP, Semenkovich CF. PPARalpha suppresses insulin secretion and induces UCP2 in insulinoma cells. Journal of Lipid Research. 43: 936-43. PMID 12032169  0.72
2001 Bergeron R, Ren JM, Cadman KS, Moore IK, Perret P, Pypaert M, Young LH, Semenkovich CF, Shulman GI. Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis. American Journal of Physiology. Endocrinology and Metabolism. 281: E1340-6. PMID 11701451  0.72
2001 Greiwe JS, Kwon G, McDaniel ML, Semenkovich CF. Leucine and insulin activate p70 S6 kinase through different pathways in human skeletal muscle. American Journal of Physiology. Endocrinology and Metabolism. 281: E466-71. PMID 11500301  0.72
2001 Polonsky KS, Semenkovich CF. The pancreatic β cell heats up: UCP2 and insulin secretion in diabetes Cell. 105: 705-707. PMID 11440712 DOI: 10.1016/S0092-8674(01)00389-0  0.72
2001 Greiwe JS, Cheng B, Rubin DC, Yarasheski KE, Semenkovich CF. Resistance exercise decreases skeletal muscle tumor necrosis factor alpha in frail elderly humans. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 15: 475-82. PMID 11156963 DOI: 10.1096/fj.00-0274com  0.72
2001 Cruz WS, Kwon G, Marshall CA, McDaniel ML, Semenkovich CF. Glucose and insulin stimulate heparin-releasable lipoprotein lipase activity in mouse islets and INS-1 cells. A potential link between insulin resistance and beta-cell dysfunction. The Journal of Biological Chemistry. 276: 12162-8. PMID 11154699 DOI: 10.1074/jbc.M010707200  0.72
2001 Tordjman K, Bernal-Mizrachi C, Zemany L, Weng S, Feng C, Zhang F, Leone TC, Coleman T, Kelly DP, Semenkovich CF. PPARα deficiency reduces insulin resistance and atherosclerosis in apoE-null mice Journal of Clinical Investigation. 107: 1025-1034.  0.72
2000 Li B, Nolte LA, Ju JS, Dong Ho Han, Coleman T, Holloszy JO, Semenkovich CF. Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice Nature Medicine. 6: 1115-1120. PMID 11017142 DOI: 10.1038/80450  0.72
2000 Greiwe JS, Holloszy JO, Semenkovich CF. Exercise induces lipoprotein lipase and GLUT-4 protein in muscle independent of adrenergic-receptor signaling Journal of Applied Physiology. 89: 176-181. PMID 10904050  0.72
2000 Babaev VR, Patel MB, Semenkovich CF, Fazio S, Linton MF. Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in low density lipoprotein receptor-deficient mice Journal of Biological Chemistry. 275: 26293-26299. PMID 10858435 DOI: 10.1074/jbc.M002423200  0.72
2000 Jakoby IV MG, Semenkovich CF. The role of osteoprogenitors in vascular calcification Current Opinion in Nephrology and Hypertension. 9: 11-15. PMID 10654819 DOI: 10.1097/00041552-200001000-00003  0.72
1999 Marshall BA, Tordjman K, Host HH, Ensor NJ, Kwon G, Marshall CA, Coleman T, McDaniel ML, Semenkovich CF. Relative hypoglycemia and hyperinsulinemia in mice with heterozygous lipoprotein lipase (LPL) deficiency. Islet LPL regulates insulin secretion. The Journal of Biological Chemistry. 274: 27426-32. PMID 10488074 DOI: 10.1074/jbc.274.39.27426  0.72
1999 Babaev VR, Fazio S, Gleaves LA, Carter KJ, Semenkovich CF, Linton MF. Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in vivo Journal of Clinical Investigation. 103: 1697-1705. PMID 10377176  0.72
1999 Li B, Holloszy JO, Semenkovich CF. Respiratory uncoupling induces δ-aminolevulinate synthase expression through a nuclear respiratory factor-1-dependent mechanism in HeLa cells Journal of Biological Chemistry. 274: 17534-17540. PMID 10364186 DOI: 10.1074/jbc.274.25.17534  0.72
1999 Semenkovich CF. Induced lipase mutations in the mouse Methods in Molecular Biology (Clifton, N.J.). 109: 343-355. PMID 9918035  0.72
1998 Semenkovich CF. Genetics and molecular biology Current Opinion in Lipidology. 9: 603-604. PMID 10075479  0.72
1998 Towler DA, Bidder M, Latifi T, Coleman T, Semenkovich CF. Diet-induced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient mice Journal of Biological Chemistry. 273: 30427-30434. PMID 9804809 DOI: 10.1074/jbc.273.46.30427  0.72
1998 Seip RL, Semenkovich CF. Skeletal Muscle Lipoprotein Lipase: Molecular Regulation and Physiological Effects in Relation to Exercise Exercise and Sport Sciences Reviews. 26: 191-218. PMID 9696990  0.72
1998 Semenkovich CF, Coleman T, Daugherty A. Effects of heterozygous lipoprotein lipase deficiency on diet-induced atherosclerosis in mice Journal of Lipid Research. 39: 1141-1151. PMID 9643345  0.72
1998 Li Q, Chua MS, Semenkovich CF. Properties and purification of a glucose-inducible human fatty acid synthase mRNA-binding protein American Journal of Physiology - Endocrinology and Metabolism. 274. PMID 9575816  0.72
1997 Excoffon KJ, Liu G, Miao L, Wilson JE, McManus BM, Semenkovich CF, Coleman T, Benoit P, Duverger N, Branellec D, Denefle P, Hayden MR, Lewis ME. Correction of hypertriglyceridemia and impaired fat tolerance in lipoprotein lipase-deficient mice by adenovirus-mediated expression of human lipoprotein lipase. Arteriosclerosis, Thrombosis, and Vascular Biology. 17: 2532-9. PMID 9409224  0.72
1997 Semenkovich CF. Regulation of fatty acid synthase (FAS) Progress in Lipid Research. 36: 43-53. PMID 9373620 DOI: 10.1016/S0163-7827(97)00003-9  0.72
1997 Seip RL, Mair K, Cole TG, Semenkovich CF. Induction of human skeletal muscle lipoprotein lipase gene expression by short-term exercise is transient American Journal of Physiology - Endocrinology and Metabolism. 272. PMID 9124332  0.72
1997 Semenkovich CF, Heinecke JW. The mystery of diabetes and atherosclerosis: time for a new plot. Diabetes. 46: 327-34. PMID 9032085  0.72
1995 Seip RL, Angelopoulos TJ, Semenkovich CF. Exercise induces human lipoprotein lipase gene expression in skeletal muscle but not adipose tissue American Journal of Physiology - Endocrinology and Metabolism. 268. PMID 7864098  0.72
1995 Coleman T, Seip RL, Gimble JM, Lee D, Maeda N, Semenkovich CF. COOH-terminal disruption of lipoprotein lipase in mice is lethal in homozygotes, but heterozygotes have elevated triglycerides and impaired enzyme activity Journal of Biological Chemistry. 270: 12518-12525. PMID 7759497 DOI: 10.1074/jbc.270.21.12518  0.72
1995 Semenkovich CF, Coleman T, Fiedorek FT. Human fatty acid synthase mRNA: Tissue distribution, genetic mapping, and kinetics of decay after glucose deprivation Journal of Lipid Research. 36: 1507-1521. PMID 7595075  0.72
1995 Dudek SM, Semenkovich CF. Essential amino acids regulate fatty acid synthase expression through an uncharged transfer RNA-dependent mechanism. The Journal of Biological Chemistry. 270: 29323-9. PMID 7493965 DOI: 10.1074/jbc.270.49.29323  0.72
1994 Ren JM, Semenkovich CF, Gulve EA, Gao J, Holloszy JO. Exercise induces rapid increases in GLUT4 expression, glucose transport capacity, and insulin-stimulated glycogen storage in muscle Journal of Biological Chemistry. 269: 14396-14401. PMID 8182045  0.72
1994 Ostlund RE, Yang JW, Heath-Monnig E, Semenkovich CF. Increased low density lipoprotein receptor expression mediated through the insulin-like growth factor-I receptor in cultured fibroblasts Molecular Endocrinology. 8: 904-909. PMID 7527123 DOI: 10.1210/me.8.7.904  0.72
1993 Semenkovich CF, Coleman T, Goforth R. Physiologic concentrations of glucose regulate fatty acid synthase activity in HepG2 cells by mediating fatty acid synthase mRNA stability Journal of Biological Chemistry. 268: 6961-6970. PMID 8463228  0.72
1993 Ren JM, Semenkovich CF, Holloszy JO. Adaptation of muscle to creatine depletion: Effect on GLUT-4 glucose transporter expression American Journal of Physiology - Cell Physiology. 264. PMID 8430763  0.72
1993 Seip RL, Moulin P, Cocke T, Tall A, Kohrt WM, Mankowitz K, Semenkovich CF, Ostlund R, Schonfeld G. Exercise training decreases plasma cholesteryl ester transfer protein Arteriosclerosis and Thrombosis. 13: 1359-1367. PMID 8364020  0.72
1992 Ishimura-Oka K, Semenkovich CF, Faustinella F, Goldberg IJ, Shachter N, Smith LC, Coleman T, Hide WA, Brown WV, Oka K, Chan L. A missense (Asp250→Asn) mutation in the lipoprotein lipase gene in two unrelated families with familial lipoprotein lipase deficiency Journal of Lipid Research. 33: 745-754. PMID 1619366  0.72
1992 Levy R, Ostlund RE, Schonfeld G, Wong P, Semenkovich CF. Cholesteryl ester storage disease: Complex molecular effects of chronic lovastatin therapy Journal of Lipid Research. 33: 1005-1015. PMID 1431581  0.72
1992 Mankowitz K, Seipa R, Semenkovich CF, Daugherty A, Schonfeld G. Short-term interruption of training affects both fasting and post-prandial lipoproteins Atherosclerosis. 95: 181-189. PMID 1418092 DOI: 10.1016/0021-9150(92)90021-8  0.72
1991 Faustinella F, Smith LC, Semenkovich CF, Chan L. Structural and functional roles of highly conserved serines in human lipoprotein lipase: Evidence that serine 132 is essential for enzyme catalysis Journal of Biological Chemistry. 266: 9481-9485. PMID 1903387  0.72
1990 Wu JH, Semenkovich CF, Chen SH, Li WH, Chan L. Apolipoprotein B mRNA Editing: Validation of a sensitive assay and developmental biology of RNA editing in the rat Journal of Biological Chemistry. 265: 12312-12316. PMID 2373694  0.72
1990 Semenkovich CF, Luo CC, Nakanishi MK, Chen SH, Smith LC, Chan L. In vitro expression and site-specific mutagenesis of the cloned human lipoprotein lipase gene: Potential n-linked glycosylation site asparagine 43 is important for both enzyme activity and secretion Journal of Biological Chemistry. 265: 5429-5433. PMID 2318821  0.72
1990 Semenkovich CF, Ostlund RE, Olson MOJ, Yang JW. A protein partially expressed on the surface of HepG2 cells that binds lipoproteins specifically is nucleolin Biochemistry. 29: 9708-9713. PMID 2176855  0.72
1989 Semenkovich CF, Chen SH, Wims M, Luo CC, Li WH, Chan L. Lipoprotein lipase and hepatic lipase mRNA tissue specific expression, developmental regulation, and evolution Journal of Lipid Research. 30: 423-431. PMID 2723548  0.72
1989 Ostlund RE, Semenkovich CF, Schechtman KB. Quantitative relationship between plasma lipids and glycohemoglobin in type 1 patients: Longitudinal study of 212 patients Diabetes Care. 12: 332-336. PMID 2721341  0.72
1989 Semenkovich CF, Wims M, Noe L, Etienne J, Chan L. Insulin regulation of lipoprotein lipase activity in 3T3-L1 adipocytes is mediated at posttranscriptional and posttranslational levels Journal of Biological Chemistry. 264: 9030-9038. PMID 2656693  0.72
1989 Semenkovich CF, Ostlund RE, Schechtman KB. Plasma Lipids in Patients With Type I Diabetes Mellitus: Influence of Race, Gender, and Plasma Glucose Control: Lipids Do Not Correlate With Glucose Control in Black Women Archives of Internal Medicine. 149: 51-56. PMID 2643418 DOI: 10.1001/archinte.1989.00390010069006  0.72
1988 Kurten RC, Navre M, Gaddy-Kurten D, Semenkovich CF, Ringold GM, Chan L, Richards JS. Induction of adenosine 3',5'-monophosphate-dependent protein kinase subunits during adipogenesis in vitro Endocrinology. 123: 2408-2418. PMID 2844511  0.72
1987 Semenkovich CF, Ostlund RE. Estrogens induce low-density lipoprotein receptor activity and decrease intracellular cholesterol in human hepatoma cell line hep G2 Biochemistry. 26: 4987-4992. PMID 2822102  0.72
1986 Levy RA, Ostlund RE, Semenkovich CF, Witztum JL. Diversity in expression of heterozygous familial hypercholesterolemia. Characterization of a unique kindred Journal of Clinical Investigation. 78: 96-101. PMID 3722389  0.72
1986 Semenkovich CF, Ostlund RE. The low density lipoprotein receptor on human peripheral blood monocytes and lymphocytes: Visualization by ligand blotting and immunoblotting techniques Journal of Clinical Endocrinology and Metabolism. 62: 1279-1287. PMID 3700586  0.72
1985 Semenkovich CF, Jaffe AS. Adverse effects due to morphine sulfate. Challenge to previous clinical doctrine The American Journal of Medicine. 79: 325-330. PMID 4036983 DOI: 10.1016/0002-9343(85)90311-0  0.72
1985 Semenkovich CF, Ostlund RE, Yang J, Reaban ME. Demonstration of functional low-density lipoprotein receptors by protein blotting in fibroblasts from a subject with homozygous receptor-negative familial hypercholesterolemia Journal of Laboratory and Clinical Medicine. 106: 47-52. PMID 2989397  0.72
1982 Semenkovich CF, Ostlund RE, Levy RA, Osa SR. Low density lipoprotein receptor activity in homozygous familial hypercholesterolemia fibroblasts Journal of Biological Chemistry. 257: 12857-12865. PMID 6290485  0.72
1979 Huskey RJ, Semenkovich CF, Griffin BE, Cecil PO, Callahan AM, Chace KV, Kirk DL. Mutants of Volvox carteri affecting nitrogen assimilation Mgg Molecular &Amp; General Genetics. 169: 157-161. DOI: 10.1007/BF00271666  0.72
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