Daniel S. Ory - Publications

Affiliations: 
Biology & Biomedical Sciences (Molecular Cell Biology) Washington University, Saint Louis, St. Louis, MO 
Area:
Molecular Biology, Cell Biology, Biochemistry

88 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Petersen D, Reinholdt P, Szomek M, Hansen SK, Poongavanam V, Dupont A, Heegaard CW, Krishnan K, Fujiwara H, Covey DF, Ory DS, Kongsted J, Wüstner D. Binding and intracellular transport of 25-hydroxycholesterol by Niemann-Pick C2 protein. Biochimica Et Biophysica Acta. Biomembranes. 183063. PMID 31521631 DOI: 10.1016/j.bbamem.2019.183063  0.44
2019 Griffiths WJ, Yutuc E, Abdel-Khalik J, Crick PJ, Hearn T, Dickson A, Bigger BW, Hoi-Yee Wu T, Goenka A, Ghosh A, Jones SA, Covey DF, Ory DS, Wang Y. Metabolism of Non-Enzymatically Derived Oxysterols: Clues from sterol metabolic disorders. Free Radical Biology & Medicine. PMID 31009661 DOI: 10.1016/j.freeradbiomed.2019.04.020  0.44
2019 Feltes M, Moores S, Gale SE, Krishnan K, Mydock-McGrane L, Covey DF, Ory DS, Schaffer JE. Synthesis and characterization of diazirine alkyne probes for the study of intracellular cholesterol trafficking. Journal of Lipid Research. PMID 30617147 DOI: 10.1194/jlr.D091470  0.44
2017 Nåbo LJ, Modzel M, Krishnan K, Covey DF, Fujiwara H, Ory DS, Szomek M, Khandelia H, Wüstner D, Kongsted J. Structural design of intrinsically fluorescent oxysterols. Chemistry and Physics of Lipids. PMID 29287905 DOI: 10.1016/j.chemphyslip.2017.12.005  0.44
2017 Castellano BM, Thelen AM, Moldavski O, Feltes M, van der Welle RE, Mydock-McGrane L, Jiang X, van Eijkeren RJ, Davis OB, Louie SM, Perera RM, Covey DF, Nomura DK, Ory DS, Zoncu R. Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex. Science (New York, N.Y.). 355: 1306-1311. PMID 28336668 DOI: 10.1126/science.aag1417  0.44
2016 Wei X, Song H, Yin L, Rizzo MG, Sidhu R, Covey DF, Ory DS, Semenkovich CF. Fatty acid synthesis configures the plasma membrane for inflammation in diabetes. Nature. PMID 27806377 DOI: 10.1038/nature20117  0.44
2016 Bradbury AM, Bagel JH, Jiang X, Swain GP, Prociuk ML, Fitzgerald CA, O'Donnell PA, Braund KG, Ory DS, Vite CH. Clinical, electrophysiological, and biochemical markers of peripheral and central nervous system disease in canine globoid cell leukodystrophy (Krabbe's disease). Journal of Neuroscience Research. 94: 1007-17. PMID 27638585 DOI: 10.1002/jnr.23838  0.44
2016 Westbroek W, Nguyen M, Siebert M, Lindstrom T, Burnett RA, Aflaki E, Jung O, Tamargo R, Rodriguez-Gil JL, Acosta W, Hendrix A, Behre B, Tayebi N, Fujiwara H, Sidhu R, ... ... Ory DS, et al. A new glucocerebrosidase-deficient neuronal cell model provides a tool to probe pathophysiology and therapeutics for Gaucher disease. Disease Models & Mechanisms. 9: 769-778. PMID 27482815 DOI: 10.1242/dmm.024588  0.44
2016 Aflaki E, Borger DK, Moaven N, Stubblefield BK, Rogers SA, Patnaik S, Schoenen FJ, Westbroek W, Zheng W, Sullivan P, Fujiwara H, Sidhu R, Khaliq ZM, Lopez GJ, Goldstein DS, ... Ory DS, et al. A New Glucocerebrosidase Chaperone Reduces α-Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 7441-52. PMID 27413154 DOI: 10.1523/JNEUROSCI.0636-16.2016  0.44
2016 Ebrahimi-Fakhari D, Wahlster L, Bartz F, Werenbeck-Ueding J, Praggastis M, Zhang J, Joggerst-Thomalla B, Theiss S, Grimm D, Ory DS, Runz H. Reduction of TMEM97 increases NPC1 protein levels and restores cholesterol trafficking in Niemann-Pick type C1 disease cells. Human Molecular Genetics. PMID 27378690 DOI: 10.1093/hmg/ddw204  0.36
2016 Jiang X, Sidhu R, Mydock-McGrane L, Hsu FF, Covey DF, Scherrer DE, Earley B, Gale SE, Farhat NY, Porter FD, Dietzen DJ, Orsini JJ, Berry-Kravis E, Zhang X, Reunert J, ... ... Ory DS, et al. Development of a bile acid-based newborn screen for Niemann-Pick disease type C. Science Translational Medicine. 8: 337ra63. PMID 27147587 DOI: 10.1126/scitranslmed.aaf2326  0.44
2016 Jiang X, Ory DS. Towards a New Diagnostic Standard for Niemann-Pick C Disease. Ebiomedicine. 4: 18-9. PMID 26981565 DOI: 10.1016/j.ebiom.2016.01.004  0.44
2016 Adebali O, Reznik AO, Ory DS, Zhulin IB. Establishing the precise evolutionary history of a gene improves prediction of disease-causing missense mutations. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 26890452 DOI: 10.1038/gim.2015.208  0.44
2015 Iaea DB, Gale SE, Bielska AA, Krishnan K, Fujiwara H, Jiang H, Maxfield FR, Schlesinger PH, Covey DF, Schaffer JE, Ory DS. A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol. Journal of Lipid Research. PMID 26497473 DOI: 10.1194/jlr.D064287  0.44
2015 Caputa G, Zhao S, Criado AE, Ory DS, Duncan JG, Schaffer JE. RNASET2 is required for ROS propagation during oxidative stress-mediated cell death. Cell Death and Differentiation. PMID 26206090 DOI: 10.1038/cdd.2015.105  0.44
2015 Praggastis M, Tortelli B, Zhang J, Fujiwara H, Sidhu R, Chacko A, Chen Z, Chung C, Lieberman AP, Sikora J, Davidson C, Walkley SU, Pipalia NH, Maxfield FR, Schaffer JE, ... Ory DS, et al. A Murine Niemann-Pick C1 I1061T Knock-In Model Recapitulates the Pathological Features of the Most Prevalent Human Disease Allele. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 8091-106. PMID 26019327 DOI: 10.1523/JNEUROSCI.4173-14.2015  0.44
2015 Hawkins-Salsbury JA, Shea L, Jiang X, Hunter DA, Guzman AM, Reddy AS, Qin EY, Li Y, Gray SJ, Ory DS, Sands MS. Mechanism-based combination treatment dramatically increases therapeutic efficacy in murine globoid cell leukodystrophy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 6495-505. PMID 25904800 DOI: 10.1523/JNEUROSCI.4199-14.2015  0.44
2015 Sidhu R, Jiang H, Farhat NY, Carrillo-Carrasco N, Woolery M, Ottinger E, Porter FD, Schaffer JE, Ory DS, Jiang X. A validated LC-MS/MS assay for quantification of 24(S)-hydroxycholesterol in plasma and cerebrospinal fluid. Journal of Lipid Research. 56: 1222-33. PMID 25866316 DOI: 10.1194/jlr.D058487  0.44
2015 Holley CL, Li MW, Scruggs BS, Matkovich SJ, Ory DS, Schaffer JE. Cytosolic accumulation of small nucleolar RNAs (snoRNAs) is dynamically regulated by NADPH oxidase. The Journal of Biological Chemistry. 290: 11741-8. PMID 25792744 DOI: 10.1074/jbc.M115.637413  0.44
2015 Vite CH, Bagel JH, Swain GP, Prociuk M, Sikora TU, Stein VM, O'Donnell P, Ruane T, Ward S, Crooks A, Li S, Mauldin E, Stellar S, De Meulder M, Kao ML, ... Ory DS, et al. Intracisternal cyclodextrin prevents cerebellar dysfunction and Purkinje cell death in feline Niemann-Pick type C1 disease. Science Translational Medicine. 7: 276ra26. PMID 25717099 DOI: 10.1126/scitranslmed.3010101  0.44
2015 Bowler RP, Jacobson S, Cruickshank C, Hughes GJ, Siska C, Ory DS, Petrache I, Schaffer JE, Reisdorph N, Kechris K. Plasma sphingolipids associated with chronic obstructive pulmonary disease phenotypes. American Journal of Respiratory and Critical Care Medicine. 191: 275-84. PMID 25494452 DOI: 10.1164/rccm.201410-1771OC  0.44
2015 Jinn S, Brandis KA, Ren A, Chacko A, Dudley-Rucker N, Gale SE, Sidhu R, Fujiwara H, Jiang H, Olsen BN, Schaffer JE, Ory DS. SnoRNA U17 regulates cellular cholesterol trafficking Cell Metabolism. 21: 855-867. DOI: 10.1016/j.cmet.2015.04.010  0.44
2014 Idol RA, Wozniak DF, Fujiwara H, Yuede CM, Ory DS, Kornfeld S, Vogel P. Neurologic abnormalities in mouse models of the lysosomal storage disorders mucolipidosis II and mucolipidosis III γ. Plos One. 9: e109768. PMID 25314316 DOI: 10.1371/journal.pone.0109768  0.44
2014 Daily MD, Olsen BN, Schlesinger PH, Ory DS, Baker NA. Improved Coarse-Grained Modeling of Cholesterol-Containing Lipid Bilayers. Journal of Chemical Theory and Computation. 10: 2137-2150. PMID 24910542 DOI: 10.1021/ct401028g  0.44
2014 Jiang H, Sidhu R, Fujiwara H, De Meulder M, de Vries R, Gong Y, Kao M, Porter FD, Yanjanin NM, Carillo-Carasco N, Xu X, Ottinger E, Woolery M, Ory DS, Jiang X. Development and validation of sensitive LC-MS/MS assays for quantification of HP-β-CD in human plasma and CSF. Journal of Lipid Research. 55: 1537-1548. PMID 24868096 DOI: 10.1194/jlr.D050278  0.44
2014 Bielska AA, Olsen BN, Gale SE, Mydock-McGrane L, Krishnan K, Baker NA, Schlesinger PH, Covey DF, Ory DS. Side-chain oxysterols modulate cholesterol accessibility through membrane remodeling. Biochemistry. 53: 3042-51. PMID 24758724 DOI: 10.1021/bi5000096  0.44
2014 Peyrot SM, Nachtergaele S, Luchetti G, Mydock-McGrane LK, Fujiwara H, Scherrer D, Jallouk A, Schlesinger PH, Ory DS, Covey DF, Rohatgi R. Tracking the subcellular fate of 20(s)-hydroxycholesterol with click chemistry reveals a transport pathway to the Golgi. The Journal of Biological Chemistry. 289: 11095-110. PMID 24596093 DOI: 10.1074/jbc.M113.540351  0.44
2014 te Vruchte D, Speak AO, Wallom KL, Al Eisa N, Smith DA, Hendriksz CJ, Simmons L, Lachmann RH, Cousins A, Hartung R, Mengel E, Runz H, Beck M, Amraoui Y, Imrie J, ... ... Ory DS, et al. Relative acidic compartment volume as a lysosomal storage disorder-associated biomarker. The Journal of Clinical Investigation. 124: 1320-8. PMID 24487591 DOI: 10.1172/JCI72835  0.44
2014 Hung YH, Faux NG, Killilea DW, Yanjanin N, Firnkes S, Volitakis I, Ganio G, Walterfang M, Hastings C, Porter FD, Ory DS, Bush AI. Altered transition metal homeostasis in Niemann-Pick disease, type C1. Metallomics : Integrated Biometal Science. 6: 542-53. PMID 24343124 DOI: 10.1039/c3mt00308f  0.44
2014 Ottinger EA, Kao ML, Carrillo-Carrasco N, Yanjanin N, Shankar RK, Janssen M, Brewster M, Scott I, Xu X, Cradock J, Terse P, Dehdashti SJ, Marugan J, Zheng W, Portilla L, ... ... Ory DS, et al. Collaborative development of 2-hydroxypropyl-β-cyclodextrin for the treatment of Niemann-Pick type C1 disease. Current Topics in Medicinal Chemistry. 14: 330-9. PMID 24283970 DOI: 10.2174/1568026613666131127160118  0.44
2014 Speak AO, Te Vruchte D, Davis LC, Morgan AJ, Smith DA, Yanjanin NM, Simmons L, Hartung R, Runz H, Mengel E, Beck M, Imrie J, Jacklin E, Wraith JE, Hendriksz C, ... ... Ory DS, et al. Altered distribution and function of natural killer cells in murine and human Niemann-Pick disease type C1. Blood. 123: 51-60. PMID 24235134 DOI: 10.1182/blood-2013-03-488692  0.44
2014 Tortelli B, Fujiwara H, Bagel JH, Zhang J, Sidhu R, Jiang X, Yanjanin NM, Shankar RK, Carillo-Carasco N, Heiss J, Ottinger E, Porter FD, Schaffer JE, Vite CH, Ory DS. Cholesterol homeostatic responses provide biomarkers for monitoring treatment for the neurodegenerative disease Niemann-Pick C1 (NPC1) Human Molecular Genetics. 23: 6022-6033. DOI: 10.1093/hmg/ddu331  0.44
2013 Brandis KA, Gale S, Jinn S, Langmade SJ, Dudley-Rucker N, Jiang H, Sidhu R, Ren A, Goldberg A, Schaffer JE, Ory DS. Box C/D small nucleolar RNA (snoRNA) U60 regulates intracellular cholesterol trafficking. The Journal of Biological Chemistry. 288: 35703-13. PMID 24174535 DOI: 10.1074/jbc.M113.488577  0.44
2013 Olsen BN, Bielska AA, Lee T, Daily MD, Covey DF, Schlesinger PH, Baker NA, Ory DS. The structural basis of cholesterol accessibility in membranes. Biophysical Journal. 105: 1838-47. PMID 24138860 DOI: 10.1016/j.bpj.2013.08.042  0.44
2013 Hawkins-Salsbury JA, Parameswar AR, Jiang X, Schlesinger PH, Bongarzone E, Ory DS, Demchenko AV, Sands MS. Psychosine, the cytotoxic sphingolipid that accumulates in globoid cell leukodystrophy, alters membrane architecture. Journal of Lipid Research. 54: 3303-11. PMID 24006512 DOI: 10.1194/jlr.M039610  0.44
2013 Fan M, Sidhu R, Fujiwara H, Tortelli B, Zhang J, Davidson C, Walkley SU, Bagel JH, Vite C, Yanjanin NM, Porter FD, Schaffer JE, Ory DS. Identification of Niemann-Pick C1 disease biomarkers through sphingolipid profiling. Journal of Lipid Research. 54: 2800-14. PMID 23881911 DOI: 10.1194/jlr.M040618  0.44
2013 Jiang H, Hsu FF, Farmer MS, Peterson LR, Schaffer JE, Ory DS, Jiang X. Development and validation of LC-MS/MS method for determination of very long acyl chain (C22:0 and C24:0) ceramides in human plasma. Analytical and Bioanalytical Chemistry. 405: 7357-65. PMID 23857140 DOI: 10.1007/s00216-013-7166-9  0.44
2013 Bauer P, Balding DJ, Klünemann HH, Linden DE, Ory DS, Pineda M, Priller J, Sedel F, Muller A, Chadha-Boreham H, Welford RW, Strasser DS, Patterson MC. Genetic screening for Niemann-Pick disease type C in adults with neurological and psychiatric symptoms: findings from the ZOOM study. Human Molecular Genetics. 22: 4349-56. PMID 23773996 DOI: 10.1093/hmg/ddt284  0.44
2013 Sene A, Khan AA, Cox D, Nakamura RE, Santeford A, Kim BM, Sidhu R, Onken MD, Harbour JW, Hagbi-Levi S, Chowers I, Edwards PA, Baldan A, Parks JS, Ory DS, et al. Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration. Cell Metabolism. 17: 549-61. PMID 23562078 DOI: 10.1016/j.cmet.2013.03.009  0.44
2013 Stampfer M, Theiss S, Amraoui Y, Jiang X, Keller S, Ory DS, Mengel E, Fischer C, Runz H. Niemann-Pick disease type C clinical database: cognitive and coordination deficits are early disease indicators. Orphanet Journal of Rare Diseases. 8: 35. PMID 23433426 DOI: 10.1186/1750-1172-8-35  0.44
2013 Schilling JD, Machkovech HM, He L, Sidhu R, Fujiwara H, Weber K, Ory DS, Schaffer JE. Palmitate and lipopolysaccharide trigger synergistic ceramide production in primary macrophages. The Journal of Biological Chemistry. 288: 2923-32. PMID 23250746 DOI: 10.1074/jbc.M112.419978  0.44
2013 Fu R, Wassif CA, Yanjanin NM, Watkins-Chow DE, Baxter LL, Incao A, Liscum L, Sidhu R, Firnkes S, Graham M, Ory DS, Porter FD, Pavan WJ. Efficacy of N-acetylcysteine in phenotypic suppression of mouse models of niemann-pick disease, type C1 Human Molecular Genetics. 22: 3508-3523. DOI: 10.1093/hmg/ddt206  0.44
2013 Xu M, Liu K, Swaroop M, Porter FD, Sidhu R, Firnkes S, Ory DS, Marugan JJ, Xiao J, Southall N, Pavan WJ, Davidson C, Walkley SU, Remaley AT, Baxa U, et al. δ-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders (Journal of Biological Chemistry (2012) 287, (39349-39360)) Journal of Biological Chemistry. 288: 296. DOI: 10.1074/jbc.A112.357707  0.44
2012 Xu M, Liu K, Swaroop M, Porter FD, Sidhu R, Firnkes S, Finkes S, Ory DS, Marugan JJ, Xiao J, Southall N, Pavan WJ, Davidson C, Walkley SU, Remaley AT, et al. δ-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders. The Journal of Biological Chemistry. 287: 39349-60. PMID 23035117 DOI: 10.1074/jbc.M112.357707  0.44
2012 Scruggs BS, Michel CI, Ory DS, Schaffer JE. SmD3 regulates intronic noncoding RNA biogenesis. Molecular and Cellular Biology. 32: 4092-103. PMID 22869524 DOI: 10.1128/MCB.00022-12  0.44
2012 Qin EY, Hawkins-Salsbury JA, Jiang X, Reddy AS, Farber NB, Ory DS, Sands MS. Bone marrow transplantation increases efficacy of central nervous system-directed enzyme replacement therapy in the murine model of globoid cell leukodystrophy. Molecular Genetics and Metabolism. 107: 186-96. PMID 22704480 DOI: 10.1016/j.ymgme.2012.05.021  0.44
2012 Cluzeau CV, Watkins-Chow DE, Fu R, Borate B, Yanjanin N, Dail MK, Davidson CD, Walkley SU, Ory DS, Wassif CA, Pavan WJ, Porter FD. Microarray expression analysis and identification of serum biomarkers for Niemann-Pick disease, type C1. Human Molecular Genetics. 21: 3632-46. PMID 22619379 DOI: 10.1093/hmg/dds193  0.44
2012 Xie Y, Kennedy S, Sidhu R, Luo J, Ory DS, Davidson NO. Liver X receptor agonist modulation of cholesterol efflux in mice with intestine-specific deletion of microsomal triglyceride transfer protein. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 1624-31. PMID 22580900 DOI: 10.1161/ATVBAHA.112.246066  0.44
2012 Bielska AA, Schlesinger P, Covey DF, Ory DS. Oxysterols as non-genomic regulators of cholesterol homeostasis. Trends in Endocrinology and Metabolism: Tem. 23: 99-106. PMID 22244444 DOI: 10.1016/j.tem.2011.12.002  0.44
2012 Olsen BN, Schlesinger PH, Ory DS, Baker NA. Side-chain oxysterols: from cells to membranes to molecules. Biochimica Et Biophysica Acta. 1818: 330-6. PMID 21745458 DOI: 10.1016/j.bbamem.2011.06.014  0.44
2011 Bowden KL, Bilbey NJ, Bilawchuk LM, Boadu E, Sidhu R, Ory DS, Du H, Chan T, Francis GA. Lysosomal acid lipase deficiency impairs regulation of ABCA1 gene and formation of high density lipoproteins in cholesteryl ester storage disease. The Journal of Biological Chemistry. 286: 30624-35. PMID 21757691 DOI: 10.1074/jbc.M111.274381  0.44
2011 Michel CI, Holley CL, Scruggs BS, Sidhu R, Brookheart RT, Listenberger LL, Behlke MA, Ory DS, Schaffer JE. Small nucleolar RNAs U32a, U33, and U35a are critical mediators of metabolic stress. Cell Metabolism. 14: 33-44. PMID 21723502 DOI: 10.1016/j.cmet.2011.04.009  0.44
2011 Jiang X, Sidhu R, Porter FD, Yanjanin NM, Speak AO, te Vruchte DT, Platt FM, Fujiwara H, Scherrer DE, Zhang J, Dietzen DJ, Schaffer JE, Ory DS. A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma. Journal of Lipid Research. 52: 1435-45. PMID 21518695 DOI: 10.1194/jlr.D015735  0.44
2011 Bielska AA, Ory DS, Covey DF. Synthesis of the enantiomer of the oxysterol-antagonist LY295427. Steroids. 76: 986-90. PMID 21470559 DOI: 10.1016/j.steroids.2011.03.008  0.44
2011 Olsen BN, Schlesinger PH, Ory DS, Baker NA. 25-Hydroxycholesterol increases the availability of cholesterol in phospholipid membranes. Biophysical Journal. 100: 948-56. PMID 21320439 DOI: 10.1016/j.bpj.2010.12.3728  0.44
2010 Porter FD, Scherrer DE, Lanier MH, Langmade SJ, Molugu V, Gale SE, Olzeski D, Sidhu R, Dietzen DJ, Fu R, Wassif CA, Yanjanin NM, Marso SP, House J, Vite C, ... ... Ory DS, et al. Cholesterol oxidation products are sensitive and specific blood-based biomarkers for Niemann-Pick C1 disease. Science Translational Medicine. 2: 56ra81. PMID 21048217 DOI: 10.1126/scitranslmed.3001417  0.44
2010 Ory DS, Schaffer JE. ApoA-1 in diabetes: damaged goods. Diabetes. 59: 2358-9. PMID 20876728 DOI: 10.2337/db10-1040  0.44
2010 Marquart TJ, Allen RM, Ory DS, Baldán A. miR-33 links SREBP-2 induction to repression of sterol transporters. Proceedings of the National Academy of Sciences of the United States of America. 107: 12228-32. PMID 20566875 DOI: 10.1073/pnas.1005191107  0.44
2009 Davidson CD, Ali NF, Micsenyi MC, Stephney G, Renault S, Dobrenis K, Ory DS, Vanier MT, Walkley SU. Chronic cyclodextrin treatment of murine Niemann-Pick C disease ameliorates neuronal cholesterol and glycosphingolipid storage and disease progression. Plos One. 4: e6951. PMID 19750228 DOI: 10.1371/journal.pone.0006951  0.44
2009 Ory DS. Getting a "Hold" on NPC2. Cell Metabolism. 10: 161-2. PMID 19723490 DOI: 10.1016/j.cmet.2009.08.006  0.44
2009 Brookheart RT, Michel CI, Listenberger LL, Ory DS, Schaffer JE. The non-coding RNA gadd7 is a regulator of lipid-induced oxidative and endoplasmic reticulum stress. The Journal of Biological Chemistry. 284: 7446-54. PMID 19150982 DOI: 10.1074/jbc.M806209200  0.44
2009 Gale SE, Westover EJ, Dudley N, Krishnan K, Merlin S, Scherrer DE, Han X, Zhai X, Brockman HL, Brown RE, Covey DF, Schaffer JE, Schlesinger P, Ory DS. Side chain oxygenated cholesterol regulates cellular cholesterol homeostasis through direct sterol-membrane interactions. The Journal of Biological Chemistry. 284: 1755-64. PMID 18996837 DOI: 10.1074/jbc.M807210200  0.44
2008 Zhang JR, Coleman T, Langmade SJ, Scherrer DE, Lane L, Lanier MH, Feng C, Sands MS, Schaffer JE, Semenkovich CF, Ory DS. Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking. The Journal of Clinical Investigation. 118: 2281-90. PMID 18483620 DOI: 10.1172/JCI32561  0.44
2008 Gelsthorpe ME, Baumann N, Millard E, Gale SE, Langmade SJ, Schaffer JE, Ory DS. Niemann-Pick type C1 I1061T mutant encodes a functional protein that is selected for endoplasmic reticulum-associated degradation due to protein misfolding. The Journal of Biological Chemistry. 283: 8229-36. PMID 18216017 DOI: 10.1074/jbc.M708735200  0.44
2008 Lange Y, Ory DS, Ye J, Lanier MH, Hsu FF, Steck TL. Effectors of rapid homeostatic responses of endoplasmic reticulum cholesterol and 3-hydroxy-3-methylglutaryl-CoA reductase. The Journal of Biological Chemistry. 283: 1445-55. PMID 18024962 DOI: 10.1074/jbc.M706967200  0.44
2007 Ory DS. Chylomicrons and lipoprotein lipase at the endothelial surface: bound and GAG-ged? Cell Metabolism. 5: 229-31. PMID 17403366 DOI: 10.1016/j.cmet.2007.03.003  0.44
2007 Jiang X, Ory DS, Han X. Characterization of oxysterols by electrospray ionization tandem mass spectrometry after one-step derivatization with dimethylglycine. Rapid Communications in Mass Spectrometry : Rcm. 21: 141-52. PMID 17154356 DOI: 10.1002/rcm.2820  0.44
2006 Borradaile NM, Han X, Harp JD, Gale SE, Ory DS, Schaffer JE. Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death. Journal of Lipid Research. 47: 2726-37. PMID 16960261 DOI: 10.1194/jlr.M600299-JLR200  0.44
2006 Langmade SJ, Gale SE, Frolov A, Mohri I, Suzuki K, Mellon SH, Walkley SU, Covey DF, Schaffer JE, Ory DS. Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease. Proceedings of the National Academy of Sciences of the United States of America. 103: 13807-12. PMID 16940355 DOI: 10.1073/pnas.0606218103  0.44
2006 Gale SE, Frolov A, Han X, Bickel PE, Cao L, Bowcock A, Schaffer JE, Ory DS. A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation. The Journal of Biological Chemistry. 281: 11082-9. PMID 16495223 DOI: 10.1074/jbc.M509612200  0.44
2006 Richards MR, Harp JD, Ory DS, Schaffer JE. Fatty acid transport protein 1 and long-chain acyl coenzyme A synthetase 1 interact in adipocytes. Journal of Lipid Research. 47: 665-72. PMID 16357361 DOI: 10.1194/jlr.M500514-JLR200  0.44
2006 Borradaile NM, Buhman KK, Listenberger LL, Magee CJ, Morimoto ET, Ory DS, Schaffer JE. A critical role for eukaryotic elongation factor 1A-1 in lipotoxic cell death. Molecular Biology of the Cell. 17: 770-8. PMID 16319173 DOI: 10.1091/mbc.E05-08-0742  0.44
2005 Millard EE, Gale SE, Dudley N, Zhang J, Schaffer JE, Ory DS. The sterol-sensing domain of the Niemann-Pick C1 (NPC1) protein regulates trafficking of low density lipoprotein cholesterol. The Journal of Biological Chemistry. 280: 28581-90. PMID 15908696 DOI: 10.1074/jbc.M414024200  0.44
2005 Chiu HC, Kovacs A, Blanton RM, Han X, Courtois M, Weinheimer CJ, Yamada KA, Brunet S, Xu H, Nerbonne JM, Welch MJ, Fettig NM, Sharp TL, Sambandam N, Olson KM, ... Ory DS, et al. Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy. Circulation Research. 96: 225-33. PMID 15618539 DOI: 10.1161/01.RES.0000154079.20681.B9  0.44
2004 Ory DS. Nuclear receptor signaling in the control of cholesterol homeostasis: have the orphans found a home? Circulation Research. 95: 660-70. PMID 15459087 DOI: 10.1161/01.RES.0000143422.83209.be  0.44
2004 Ory DS. The niemann-pick disease genes; regulators of cellular cholesterol homeostasis. Trends in Cardiovascular Medicine. 14: 66-72. PMID 15030792 DOI: 10.1016/j.tcm.2003.12.003  0.44
2004 Zhang J, Dudley-Rucker N, Crowley JR, Lopez-Perez E, Issandou M, Schaffer JE, Ory DS. The steroidal analog GW707 activates the SREBP pathway through disruption of intracellular cholesterol trafficking. Journal of Lipid Research. 45: 223-31. PMID 14617742 DOI: 10.1194/jlr.M300409-JLR200  0.44
2003 Frolov A, Zielinski SE, Crowley JR, Dudley-Rucker N, Schaffer JE, Ory DS. NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols. The Journal of Biological Chemistry. 278: 25517-25. PMID 12719428 DOI: 10.1074/jbc.M302588200  0.44
2003 Listenberger LL, Han X, Lewis SE, Cases S, Farese RV, Ory DS, Schaffer JE. Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 100: 3077-82. PMID 12629214 DOI: 10.1073/pnas.0630588100  0.44
2003 Richards MR, Listenberger LL, Kelly AA, Lewis SE, Ory DS, Schaffer JE. Oligomerization of the murine fatty acid transport protein 1. The Journal of Biological Chemistry. 278: 10477-83. PMID 12533547 DOI: 10.1074/jbc.M212469200  0.44
2001 Frolov A, Srivastava K, Daphna-Iken D, Traub LM, Schaffer JE, Ory DS. Cholesterol Overload Promotes Morphogenesis of a Niemann-Pick C (NPC)-like Compartment Independent of Inhibition of NPC1 or HE1/NPC2 Function Journal of Biological Chemistry. 276: 46414-46421. PMID 11571306 DOI: 10.1074/jbc.M108099200  0.44
2001 Lewis SE, Listenberger LL, Ory DS, Schaffer JE. Membrane topology of the murine fatty acid transport protein 1. The Journal of Biological Chemistry. 276: 37042-50. PMID 11470793 DOI: 10.1074/jbc.M105556200  0.44
2001 Feng X, Novack DV, Faccio R, Ory DS, Aya K, Boyer MI, McHugh KP, Ross FP, Teitelbaum SL. A Glanzmann's mutation in β3 integrin specifically impairs osteodast function Journal of Clinical Investigation. 107: 1137-1144. PMID 11342577  0.44
2001 Listenberger LL, Ory DS, Schaffer JE. Palmitate-induced apoptosis can occur through a ceramide-independent pathway. The Journal of Biological Chemistry. 276: 14890-5. PMID 11278654 DOI: 10.1074/jbc.M010286200  0.44
2001 Lai CF, Chaudhary L, Fausto A, Halstead LR, Ory DS, Avioli LV, Cheng SL. Erk Is Essential for Growth, Differentiation, Integrin Expression, and Cell Function in Human Osteoblastic Cells Journal of Biological Chemistry. 276: 14443-14450. PMID 11278600 DOI: 10.1074/jbc.M010021200  0.44
2000 Ory DS. Niemann-Pick type C: A disorder of cellular cholesterol trafficking Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids. 1529: 331-339. PMID 11111100 DOI: 10.1016/S1388-1981(00)00158-X  0.44
2000 Millard EE, Srivastava K, Traub LM, Schaffer JE, Ory DS. Niemann-pick type C1 (NPC1) overexpression alters cellular cholesterol homeostasis. The Journal of Biological Chemistry. 275: 38445-51. PMID 10964915 DOI: 10.1074/jbc.M003180200  0.44
1996 Ory DS, Neugeboren BA, Mulligan RC. A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes Proceedings of the National Academy of Sciences of the United States of America. 93: 11400-11406. PMID 8876147 DOI: 10.1073/pnas.93.21.11400  0.44
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