Sima Lev - Publications

Molecular Cell Biology Weizmann Institute of Science, Rehovot, Israel 
Molecular Biology, Microbiology Biology

46 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Verma N, Müller AK, Kothari C, Panayotopoulou E, Kedan A, Selitrennik M, Mills GB, Nguyen LK, Shin S, Karn T, Holtrich U, Lev S. Correction: Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4-NDRG1 Axis. Cancer Research. 80: 362. PMID 31941679 DOI: 10.1158/0008-5472.CAN-19-3573  1
2019 Keinan O, Kedan A, Gavert N, Selitrennik M, Kim S, Karn T, Becker S, Lev S. Correction: The lipid-transfer protein Nir2 enhances epithelial-mesenchymal transition and facilitates breast cancer metastasis (doi:10.1242/jcs.155721). Journal of Cell Science. 132. PMID 30846603 DOI: 10.1242/jcs.227868  0.6
2018 Kedan A, Verma N, Saroha A, Shreberk-Shaked M, Müller AK, Nair NU, Lev S. PYK2 negatively regulates the Hippo pathway in TNBC by stabilizing TAZ protein. Cell Death & Disease. 9: 985. PMID 30250159 DOI: 10.1038/s41419-018-1005-z  1
2018 Shin SY, Müller AK, Verma N, Lev S, Nguyen LK. Systems modelling of the EGFR-PYK2-c-Met interaction network predicts and prioritizes synergistic drug combinations for triple-negative breast cancer. Plos Computational Biology. 14: e1006192. PMID 29920512 DOI: 10.1371/journal.pcbi.1006192  1
2017 Panayotopoulou EG, Müller AK, Börries M, Busch H, Hu G, Lev S. Targeting of apoptotic pathways by SMAC or BH3 mimetics distinctly sensitizes paclitaxel-resistant triple negative breast cancer cells. Oncotarget. PMID 28187446 DOI: 10.18632/oncotarget.15125  1
2016 Yu J, Lei R, Zhuang X, Li X, Li G, Lev S, Segura MF, Zhang X, Hu G. MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells. Nature Communications. 7: 13884. PMID 27996004 DOI: 10.1038/ncomms13884  1
2016 Verma N, Müller AK, Kothari C, Panayotopoulou E, Kedan A, Selitrennik M, Mills GB, Nguyen LK, Shin S, Karn T, Holtrich U, Lev S. Targeting of PYK2 synergizes with EGFR antagonists in basal-like TNBC and circumvents HER3-associated resistance via the NEDD4-NDRG1 axis. Cancer Research. PMID 27793840 DOI: 10.1158/0008-5472.CAN-16-1797  1
2016 Selitrennik M, Lev S. The role of phosphatidylinositol-transfer proteins at membrane contact sites. Biochemical Society Transactions. 44: 419-24. PMID 27068949 DOI: 10.1042/BST20150182  1
2015 Selitrennik M, Lev S. PYK2 integrates growth factor and cytokine receptors signaling and potentiates breast cancer invasion via a positive feedback loop. Oncotarget. 6: 22214-26. PMID 26084289 DOI: 10.18632/oncotarget.4257  1
2015 Verma N, Keinan O, Selitrennik M, Karn T, Filipits M, Lev S. PYK2 sustains endosomal-derived receptor signalling and enhances epithelial-to-mesenchymal transition. Nature Communications. 6: 6064. PMID 25648557 DOI: 10.1038/ncomms7064  1
2014 Keinan O, Kedan A, Gavert N, Selitrennik M, Kim S, Karn T, Becker S, Lev S. The lipid-transfer protein Nir2 enhances epithelial-mesenchymal transition and facilitates breast cancer metastasis. Journal of Cell Science. 127: 4740-9. PMID 25179602 DOI: 10.1242/jcs.155721  1
2014 Hong W, Lev S. Tethering the assembly of SNARE complexes. Trends in Cell Biology. 24: 35-43. PMID 24119662 DOI: 10.1016/j.tcb.2013.09.006  1
2013 Kim S, Kedan A, Marom M, Gavert N, Keinan O, Selitrennik M, Laufman O, Lev S. The phosphatidylinositol-transfer protein Nir2 binds phosphatidic acid and positively regulates phosphoinositide signalling. Embo Reports. 14: 891-9. PMID 23897088 DOI: 10.1038/embor.2013.113  1
2013 Laufman O, Freeze HH, Hong W, Lev S. Deficiency of the Cog8 subunit in normal and CDG-derived cells impairs the assembly of the COG and Golgi SNARE complexes. Traffic (Copenhagen, Denmark). 14: 1065-77. PMID 23865579 DOI: 10.1111/tra.12093  1
2013 Laufman O, Hong W, Lev S. The COG complex interacts with multiple Golgi SNAREs and enhances fusogenic assembly of SNARE complexes. Journal of Cell Science. 126: 1506-16. PMID 23378023 DOI: 10.1242/jcs.122101  1
2012 Lev S. Nonvesicular lipid transfer from the endoplasmic reticulum. Cold Spring Harbor Perspectives in Biology. 4. PMID 23028121 DOI: 10.1101/cshperspect.a013300  1
2011 Laufman O, Hong W, Lev S. The COG complex interacts directly with Syntaxin 6 and positively regulates endosome-to-TGN retrograde transport. The Journal of Cell Biology. 194: 459-72. PMID 21807881 DOI: 10.1083/jcb.201102045  1
2010 Lev S. Non-vesicular lipid transport by lipid-transfer proteins and beyond. Nature Reviews. Molecular Cell Biology. 11: 739-50. PMID 20823909 DOI: 10.1038/nrm2971  1
2010 Kim S, Leal SS, Ben Halevy D, Gomes CM, Lev S. Structural requirements for VAP-B oligomerization and their implication in amyotrophic lateral sclerosis-associated VAP-B(P56S) neurotoxicity. The Journal of Biological Chemistry. 285: 13839-49. PMID 20207736 DOI: 10.1074/jbc.M109.097345  1
2009 Laufman O, Kedan A, Hong W, Lev S. Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing. The Embo Journal. 28: 2006-17. PMID 19536132 DOI: 10.1038/emboj.2009.168  1
2008 Krishnan MN, Ng A, Sukumaran B, Gilfoy FD, Uchil PD, Sultana H, Brass AL, Adametz R, Tsui M, Qian F, Montgomery RR, Lev S, Mason PW, Koski RA, Elledge SJ, et al. RNA interference screen for human genes associated with West Nile virus infection. Nature. 455: 242-5. PMID 18690214 DOI: 10.1038/nature07207  1
2008 Peretti D, Dahan N, Shimoni E, Hirschberg K, Lev S. Coordinated lipid transfer between the endoplasmic reticulum and the Golgi complex requires the VAP proteins and is essential for Golgi-mediated transport. Molecular Biology of the Cell. 19: 3871-84. PMID 18614794 DOI: 10.1091/mbc.E08-05-0498  1
2008 Lev S, Ben Halevy D, Peretti D, Dahan N. The VAP protein family: from cellular functions to motor neuron disease. Trends in Cell Biology. 18: 282-90. PMID 18468439 DOI: 10.1016/j.tcb.2008.03.006  1
2006 Lev S. Lipid homoeostasis and Golgi secretory function Biochemical Society Transactions. 34: 363-366. PMID 16709162 DOI: 10.1042/BST0340363  1
2005 Litvak V, Dahan N, Ramachandran S, Sabanay H, Lev S. Maintenance of the diacylglycerol level in the Golgi apparatus by the Nir2 protein is critical for Golgi secretory function. Nature Cell Biology. 7: 225-34. PMID 15723057 DOI: 10.1038/ncb1221  1
2005 Amarilio R, Ramachandran S, Sabanay H, Lev S. Differential regulation of endoplasmic reticulum structure through VAP-Nir protein interaction. The Journal of Biological Chemistry. 280: 5934-44. PMID 15545272 DOI: 10.1074/jbc.M409566200  1
2005 Corvol JC, Valjent E, Toutant M, Enslen H, Irinopoulou T, Lev S, Hervé D, Girault JA. Depolarization activates ERK and proline-rich tyrosine kinase 2 (PYK2) independently in different cellular compartments in hippocampal slices. The Journal of Biological Chemistry. 280: 660-8. PMID 15537634 DOI: 10.1074/jbc.M411312200  1
2004 Rolls A, Avidan H, Cahalon L, Schori H, Bakalash S, Litvak V, Lev S, Lider O, Schwartz M. A disaccharide derived from chondroitin sulphate proteoglycan promotes central nervous system repair in rats and mice. The European Journal of Neuroscience. 20: 1973-83. PMID 15450076 DOI: 10.1111/j.1460-9568.2004.03676.x  1
2004 Lev S. The role of the Nir/rdgB protein family in membrane trafficking and cytoskeleton remodeling. Experimental Cell Research. 297: 1-10. PMID 15194420 DOI: 10.1016/j.yexcr.2004.02.033  1
2004 Litvak V, Argov R, Dahan N, Ramachandran S, Amarilio R, Shainskaya A, Lev S. Mitotic phosphorylation of the peripheral Golgi protein Nir2 by Cdk1 provides a docking mechanism for Plk1 and affects cytokinesis completion. Molecular Cell. 14: 319-30. PMID 15125835 DOI: 10.1016/S1097-2765(04)00214-X  1
2003 Rubin C, Litvak V, Medvedovsky H, Zwang Y, Lev S, Yarden Y. Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops. Current Biology : Cb. 13: 297-307. PMID 12593795 DOI: 10.1016/S0960-9822(03)00053-8  1
2002 Litvak V, Shaul YD, Shulewitz M, Amarilio R, Carmon S, Lev S. Targeting of Nir2 to lipid droplets is regulated by a specific threonine residue within its PI-transfer domain. Current Biology : Cb. 12: 1513-8. PMID 12225667 DOI: 10.1016/S0960-9822(02)01107-7  1
2002 Litvak V, Tian D, Carmon S, Lev S. Nir2, a human homolog of Drosophila melanogaster retinal degeneration B protein, is essential for cytokinesis. Molecular and Cellular Biology. 22: 5064-75. PMID 12077336 DOI: 10.1128/MCB.22.14.5064-5075.2002  1
2002 Tian D, Lev S. Cellular and developmental distribution of human homologues of the Drosophilia rdgB protein in the rat retina. Investigative Ophthalmology & Visual Science. 43: 1946-53. PMID 12037004  1
2002 Tian D, Litvak V, Toledo-Rodriguez M, Carmon S, Lev S. Nir2, a novel regulator of cell morphogenesis. Molecular and Cellular Biology. 22: 2650-62. PMID 11909959 DOI: 10.1128/MCB.22.8.2650-2662.2002  1
2001 Lev S. Molecular aspects of retinal degenerative diseases Cellular and Molecular Neurobiology. 21: 575-589. PMID 12043834 DOI: 10.1023/A:1015183500719  1
2000 Tian D, Litvak V, Lev S. Cerebral ischemia and seizures induce tyrosine phosphorylation of PYK2 in neurons and microglial cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 6478-87. PMID 10964954  1
2000 Litvak V, Tian D, Shaul YD, Lev S. Targeting of PYK2 to focal adhesions as a cellular mechanism for convergence between integrins and G protein-coupled receptor signaling cascades. The Journal of Biological Chemistry. 275: 32736-46. PMID 10915788 DOI: 10.1074/jbc.M004200200  1
1996 Tokiwa G, Dikic I, Lev S, Schlessinger J. Activation of Pyk2 by stress signals and coupling with JNK signaling pathway. Science (New York, N.Y.). 273: 792-4. PMID 8670418  1
1994 Lev S, Blechman JM, Givol D, Yarden Y. Steel factor and c-kit protooncogene: Genetic lessons in signal transduction Critical Reviews in Oncogenesis. 5: 141-168. PMID 7531500  1
1993 Blechman JM, Lev S, Givol D, Yarden Y. Structure-function analyses of the Kit receptor for the steel factor Stem Cells. 11: 12-21. PMID 7691317  1
1992 Lev S, Yarden Y, Givol D. Dimerization and activation of the kit receptor by monovalent and bivalent binding of the stem cell factor Journal of Biological Chemistry. 267: 15970-15977. PMID 1379243  1
1992 Lev S, Yarden Y, Givol D. A recombinant ectodomain of the receptor for the Stem Cell Factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses Journal of Biological Chemistry. 267: 10866-10873. PMID 1375232  1
1992 Lev S, Givol D, Yarden Y. Interkinase domain of kit contains the binding site for phosphatidylinositol 3' kinase Proceedings of the National Academy of Sciences of the United States of America. 89: 678-682. PMID 1370584  1
1991 Lev S, Givol D, Yarden Y. A specific combination of substrates is involved in signal transduction by the kit-encoded receptor Embo Journal. 10: 647-654. PMID 1705885  1
1990 Lev S, Yarden Y, Givol D. Receptor functions and ligand-dependent transforming potential of a chimeric kit proto-oncogene Molecular and Cellular Biology. 10: 6064-6068. PMID 1700279  1
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