Timothy J. Ley - Publications

Affiliations: 
Biology & Biomedical Sciences (Molecular Cell Biology) Washington University, Saint Louis, St. Louis, MO 
Area:
Molecular Biology, Cell Biology, Genetics

199 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Trissal MC, Wong TN, Yao JC, Ramaswamy R, Kuo I, Baty JD, Sun Y, Jih G, Parikh N, Berrien-Elliott MM, Fehniger TA, Ley TJ, Maillard I, Reddy P, Link DC. MIR142 loss-of-function mutations derepress ASH1L to increase HOXA gene expression and promote leukemogenesis. Cancer Research. PMID 29724719 DOI: 10.1158/0008-5472.CAN-17-3592  0.52
2016 Welch JS, Petti AA, Miller CA, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Baty JD, Duncavage EJ, Tandon B, Lee YS, Wartman LD, Uy GL, Ghobadi A, Tomasson MH, ... ... Ley TJ, et al. TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes. The New England Journal of Medicine. 375: 2023-2036. PMID 27959731 DOI: 10.1056/NEJMoa1605949  0.52
2016 Griffith M, Griffith OL, Krysiak K, Skidmore ZL, Christopher MJ, Klco JM, Ramu A, Lamprecht TL, Wagner AH, Campbell KM, Lesurf R, Hundal J, Zhang J, Spies NC, Ainscough BJ, ... ... Ley TJ, et al. Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B lymphoblastic leukemia. Experimental Hematology. PMID 27181063 DOI: 10.1016/j.exphem.2016.04.011  0.52
2016 Cole CB, Verdoni AM, Ketkar S, Leight ER, Russler-Germain DA, Lamprecht TL, Demeter RT, Magrini V, Ley TJ. PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia. The Journal of Clinical Investigation. 126: 85-98. PMID 26595813 DOI: 10.1172/JCI82897  0.52
2015 Klco JM, Miller CA, Griffith M, Petti A, Spencer DH, Ketkar-Kulkarni S, Wartman LD, Christopher M, Lamprecht TL, Helton NM, Duncavage EJ, Payton JE, Baty J, Heath SE, Griffith OL, ... ... Ley TJ, et al. Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia. Jama. 314: 811-22. PMID 26305651 DOI: 10.1001/jama.2015.9643  0.52
2015 Li C, Klco JM, Helton NM, George DR, Mudd JL, Miller CA, Lu C, Fulton R, O'Laughlin M, Fronick C, Wilson RK, Ley TJ. Genetic heterogeneity of induced pluripotent stem cells: results from 24 clones derived from a single C57BL/6 mouse. Plos One. 10: e0120585. PMID 25799070 DOI: 10.1371/journal.pone.0120585  0.52
2014 Ding L, Kim M, Kanchi KL, Dees ND, Lu C, Griffith M, Fenstermacher D, Sung H, Miller CA, Goetz B, Wendl MC, Griffith O, Cornelius LA, Linette GP, McMichael JF, ... ... Ley TJ, et al. Clonal architectures and driver mutations in metastatic melanomas. Plos One. 9: e111153. PMID 25393105 DOI: 10.1371/journal.pone.0111153  0.52
2014 Lu EP, McLellan M, Ding L, Fulton R, Mardis ER, Wilson RK, Miller CA, Westervelt P, DiPersio JF, Link DC, Walter MJ, Ley TJ, Graubert TA. Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice. Blood. 124: 3887-95. PMID 25349173 DOI: 10.1182/blood-2014-06-582551  0.52
2014 Xie M, Lu C, Wang J, McLellan MD, Johnson KJ, Wendl MC, McMichael JF, Schmidt HK, Yellapantula V, Miller CA, Ozenberger BA, Welch JS, Link DC, Walter MJ, Mardis ER, ... ... Ley TJ, et al. Age-related mutations associated with clonal hematopoietic expansion and malignancies. Nature Medicine. 20: 1472-8. PMID 25326804 DOI: 10.1038/nm.3733  0.52
2014 Sarkaria SM, Christopher MJ, Klco JM, Ley TJ. Primary acute myeloid leukemia cells with IDH1 or IDH2 mutations respond to a DOT1L inhibitor in vitro. Leukemia. 28: 2403-6. PMID 25092143 DOI: 10.1038/leu.2014.235  0.52
2014 Hughes AE, Magrini V, Demeter R, Miller CA, Fulton R, Fulton LL, Eades WC, Elliott K, Heath S, Westervelt P, Ding L, Conrad DF, White BS, Shao J, Link DC, ... ... Ley TJ, et al. Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing. Plos Genetics. 10: e1004462. PMID 25010716 DOI: 10.1371/journal.pgen.1004462  0.52
2014 Russler-Germain DA, Spencer DH, Young MA, Lamprecht TL, Miller CA, Fulton R, Meyer MR, Erdmann-Gilmore P, Townsend RR, Wilson RK, Ley TJ. The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers. Cancer Cell. 25: 442-54. PMID 24656771 DOI: 10.1016/j.ccr.2014.02.010  0.52
2014 Klco JM, Spencer DH, Miller CA, Griffith M, Lamprecht TL, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Fulton RS, Eades WC, Link DC, Graubert TA, Walter MJ, Mardis ER, ... ... Ley TJ, et al. Functional heterogeneity of genetically defined subclones in acute myeloid leukemia. Cancer Cell. 25: 379-92. PMID 24613412 DOI: 10.1016/j.ccr.2014.01.031  0.52
2013 Kandoth C, McLellan MD, Vandin F, Ye K, Niu B, Lu C, Xie M, Zhang Q, McMichael JF, Wyczalkowski MA, Leiserson MD, Miller CA, Welch JS, Walter MJ, Wendl MC, ... Ley TJ, et al. Mutational landscape and significance across 12 major cancer types. Nature. 502: 333-9. PMID 24132290 DOI: 10.1038/nature12634  0.52
2013 Griffith M, Griffith OL, Coffman AC, Weible JV, McMichael JF, Spies NC, Koval J, Das I, Callaway MB, Eldred JM, Miller CA, Subramanian J, Govindan R, Kumar RD, Bose R, ... ... Ley TJ, et al. DGIdb: mining the druggable genome. Nature Methods. 10: 1209-10. PMID 24122041 DOI: 10.1038/nmeth.2689  0.52
2013 Ramsingh G, Jacoby MA, Shao J, De Jesus Pizzaro RE, Shen D, Trissal M, Getz AH, Ley TJ, Walter MJ, Link DC. Acquired copy number alterations of miRNA genes in acute myeloid leukemia are uncommon. Blood. 122: e44-51. PMID 24009227 DOI: 10.1182/blood-2013-03-488007  0.52
2013 Chen K, Navin NE, Wang Y, Schmidt HK, Wallis JW, Niu B, Fan X, Zhao H, McLellan MD, Hoadley KA, Mardis ER, Ley TJ, Perou CM, Wilson RK, Ding L. BreakTrans: uncovering the genomic architecture of gene fusions. Genome Biology. 14: R87. PMID 23972288 DOI: 10.1186/gb-2013-14-8-r87  0.52
2013 Ley TJ, Miller C, Ding L, Raphael BJ, Mungall AJ, Robertson G, Hoadley K, Triche TJ, Laird PW, Baty JD, Fulton LL, Fulton R, Heath SE, Kalicki-Veizer J, Kandoth C, et al. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia New England Journal of Medicine. 368: 2059-2074. PMID 23634996 DOI: 10.1056/NadEJMoa1301689  0.52
2013 Grieselhuber NR, Klco JM, Verdoni AM, Lamprecht T, Sarkaria SM, Wartman LD, Ley TJ. Notch signaling in acute promyelocytic leukemia. Leukemia. 27: 1548-57. PMID 23455394 DOI: 10.1038/leu.2013.68  0.52
2013 Walter MJ, Shen D, Shao J, Ding L, White BS, Kandoth C, Miller CA, Niu B, McLellan MD, Dees ND, Fulton R, Elliot K, Heath S, Grillot M, Westervelt P, ... ... Ley TJ, et al. Clonal diversity of recurrently mutated genes in myelodysplastic syndromes. Leukemia. 27: 1275-82. PMID 23443460 DOI: 10.1038/leu.2013.58  0.52
2013 Klco JM, Spencer DH, Lamprecht TL, Sarkaria SM, Wylie T, Magrini V, Hundal J, Walker J, Varghese N, Erdmann-Gilmore P, Lichti CF, Meyer MR, Townsend RR, Wilson RK, Mardis ER, ... Ley TJ, et al. Genomic impact of transient low-dose decitabine treatment on primary AML cells. Blood. 121: 1633-43. PMID 23297133 DOI: 10.1182/blood-2012-09-459313  0.52
2012 Gruber TA, Larson Gedman A, Zhang J, Koss CS, Marada S, Ta HQ, Chen SC, Su X, Ogden SK, Dang J, Wu G, Gupta V, Andersson AK, Pounds S, Shi L, ... ... Ley TJ, et al. An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia. Cancer Cell. 22: 683-97. PMID 23153540 DOI: 10.1016/j.ccr.2012.10.007  0.52
2012 Wartman LD, Welch JS, Uy GL, Klco JM, Lamprecht T, Varghese N, Nagarajan R, Ley TJ. Expression and function of PML-RARA in the hematopoietic progenitor cells of Ctsg-PML-RARA mice. Plos One. 7: e46529. PMID 23056333 DOI: 10.1371/journal.pone.0046529  0.52
2012 Welch JS, Ley TJ, Link DC, Miller CA, Larson DE, Koboldt DC, Wartman LD, Lamprecht TL, Liu F, Xia J, Kandoth C, Fulton RS, McLellan MD, Dooling DJ, Wallis JW, et al. The origin and evolution of mutations in acute myeloid leukemia. Cell. 150: 264-78. PMID 22817890 DOI: 10.1016/j.cell.2012.06.023  0.52
2012 Ellis MJ, Ding L, Shen D, Luo J, Suman VJ, Wallis JW, Van Tine BA, Hoog J, Goiffon RJ, Goldstein TC, Ng S, Lin L, Crowder R, Snider J, Ballman K, ... ... Ley TJ, et al. Whole-genome analysis informs breast cancer response to aromatase inhibition. Nature. 486: 353-60. PMID 22722193 DOI: 10.1038/nature11143  0.52
2012 Downing JR, Wilson RK, Zhang J, Mardis ER, Pui CH, Ding L, Ley TJ, Evans WE. The Pediatric Cancer Genome Project. Nature Genetics. 44: 619-22. PMID 22641210 DOI: 10.1038/ng.2287  0.52
2012 Chen K, Wallis JW, Kandoth C, Kalicki-Veizer JM, Mungall KL, Mungall AJ, Jones SJ, Marra MA, Ley TJ, Mardis ER, Wilson RK, Weinstein JN, Ding L. BreakFusion: targeted assembly-based identification of gene fusions in whole transcriptome paired-end sequencing data. Bioinformatics (Oxford, England). 28: 1923-4. PMID 22563071 DOI: 10.1093/bioinformatics/bts272  0.52
2012 Young MA, Larson DE, Sun CW, George DR, Ding L, Miller CA, Lin L, Pawlik KM, Chen K, Fan X, Schmidt H, Kalicki-Veizer J, Cook LL, Swift GW, Demeter RT, ... ... Ley TJ, et al. Background mutations in parental cells account for most of the genetic heterogeneity of induced pluripotent stem cells. Cell Stem Cell. 10: 570-82. PMID 22542160 DOI: 10.1016/j.stem.2012.03.002  0.52
2012 Walter MJ, Shen D, Ding L, Shao J, Koboldt DC, Chen K, Larson DE, McLellan MD, Dooling D, Abbott R, Fulton R, Magrini V, Schmidt H, Kalicki-Veizer J, O'Laughlin M, ... ... Ley TJ, et al. Clonal architecture of secondary acute myeloid leukemia. The New England Journal of Medicine. 366: 1090-8. PMID 22417201 DOI: 10.1056/NEJMoa1106968  0.52
2012 Zhang J, Ding L, Holmfeldt L, Wu G, Heatley SL, Payne-Turner D, Easton J, Chen X, Wang J, Rusch M, Lu C, Chen SC, Wei L, Collins-Underwood JR, Ma J, ... ... Ley TJ, et al. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature. 481: 157-63. PMID 22237106 DOI: 10.1038/nature10725  0.52
2012 Ding L, Ley TJ, Larson DE, Miller CA, Koboldt DC, Welch JS, Ritchey JK, Young MA, Lamprecht T, McLellan MD, McMichael JF, Wallis JW, Lu C, Shen D, Harris CC, et al. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature. 481: 506-10. PMID 22237025 DOI: 10.1038/nature10738  0.52
2012 Graubert TA, Shen D, Ding L, Okeyo-Owuor T, Lunn CL, Shao J, Krysiak K, Harris CC, Koboldt DC, Larson DE, McLellan MD, Dooling DJ, Abbott RM, Fulton RS, Schmidt H, ... ... Ley TJ, et al. Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes. Nature Genetics. 44: 53-7. PMID 22158538 DOI: 10.1038/ng.1031  0.52
2012 Larson DE, Harris CC, Chen K, Koboldt DC, Abbott TE, Dooling DJ, Ley TJ, Mardis ER, Wilson RK, Ding L. SomaticSniper: identification of somatic point mutations in whole genome sequencing data. Bioinformatics (Oxford, England). 28: 311-7. PMID 22155872 DOI: 10.1093/bioinformatics/btr665  0.52
2011 Welch JS, Westervelt P, Ding L, Larson DE, Klco JM, Kulkarni S, Wallis J, Chen K, Payton JE, Fulton RS, Veizer J, Schmidt H, Vickery TL, Heath S, Watson MA, ... ... Ley TJ, et al. Use of whole-genome sequencing to diagnose a cryptic fusion oncogene. Jama. 305: 1577-84. PMID 21505136 DOI: 10.1001/jama.2011.497  0.52
2011 Link DC, Schuettpelz LG, Shen D, Wang J, Walter MJ, Kulkarni S, Payton JE, Ivanovich J, Goodfellow PJ, Le Beau M, Koboldt DC, Dooling DJ, Fulton RS, Bender RH, Fulton LL, ... ... Ley TJ, et al. Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML. Jama. 305: 1568-76. PMID 21505135 DOI: 10.1001/jama.2011.473  0.52
2011 Wartman LD, Larson DE, Xiang Z, Ding L, Chen K, Lin L, Cahan P, Klco JM, Welch JS, Li C, Payton JE, Uy GL, Varghese N, Ries RE, Hoock M, ... ... Ley TJ, et al. Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression. The Journal of Clinical Investigation. 121: 1445-55. PMID 21436584 DOI: 10.1172/JCI45284  0.52
2011 Walter MJ, Ding L, Shen D, Shao J, Grillot M, McLellan M, Fulton R, Schmidt H, Kalicki-Veizer J, O'Laughlin M, Kandoth C, Baty J, Westervelt P, Dipersio JF, Mardis ER, ... ... Ley TJ, et al. Recurrent DNMT3A mutations in patients with myelodysplastic syndromes Leukemia. 25: 1153-1158. PMID 21415852 DOI: 10.1038/leu.2011.44  0.52
2011 Welch JS, Yuan W, Ley TJ. PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice. The Journal of Clinical Investigation. 121: 1636-45. PMID 21364283 DOI: 10.1172/JCI42953  0.52
2011 Welch JS, Klco JM, Varghese N, Nagarajan R, Ley TJ. Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice. Blood. 117: 2460-8. PMID 21190992 DOI: 10.1182/blood-2010-08-300087  0.52
2010 Ley TJ, Ding L, Walter MJ, McLellan MD, Lamprecht T, Larson DE, Kandoth C, Payton JE, Baty J, Welch J, Harris CC, Lichti CF, Townsend RR, Fulton RS, Dooling DJ, et al. DNMT3A mutations in acute myeloid leukemia. The New England Journal of Medicine. 363: 2424-33. PMID 21067377 DOI: 10.1056/NEJMoa1005143  0.52
2010 Fehniger TA, Wylie T, Germino E, Leong JW, Magrini VJ, Koul S, Keppel CR, Schneider SE, Koboldt DC, Sullivan RP, Heinz ME, Crosby SD, Nagarajan R, Ramsingh G, Link DC, ... Ley TJ, et al. Next-generation sequencing identifies the natural killer cell microRNA transcriptome. Genome Research. 20: 1590-604. PMID 20935160 DOI: 10.1101/gr.107995.110  0.52
2010 Ramsingh G, Koboldt DC, Trissal M, Chiappinelli KB, Wylie T, Koul S, Chang LW, Nagarajan R, Fehniger TA, Goodfellow P, Magrini V, Wilson RK, Ding L, Ley TJ, Mardis ER, et al. Complete characterization of the microRNAome in a patient with acute myeloid leukemia. Blood. 116: 5316-26. PMID 20876853 DOI: 10.1182/blood-2010-05-285395  0.52
2010 Uy GL, Lane AA, Welch JS, Grieselhuber NR, Payton JE, Ley TJ. A protease-resistant PML-RAR{alpha} has increased leukemogenic potential in a murine model of acute promyelocytic leukemia. Blood. 116: 3604-10. PMID 20647568 DOI: 10.1182/blood-2008-11-189282  0.52
2010 Xiang Z, Luo H, Payton JE, Cain J, Ley TJ, Opferman JT, Tomasson MH. Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia. The Journal of Clinical Investigation. 120: 2109-18. PMID 20484815 DOI: 10.1172/JCI39964  0.52
2010 Ding L, Ellis MJ, Li S, Larson DE, Chen K, Wallis JW, Harris CC, McLellan MD, Fulton RS, Fulton LL, Abbott RM, Hoog J, Dooling DJ, Koboldt DC, Schmidt H, ... ... Ley TJ, et al. Genome remodelling in a basal-like breast cancer metastasis and xenograft. Nature. 464: 999-1005. PMID 20393555 DOI: 10.1038/nature08989  0.52
2010 Fortier JM, Payton JE, Cahan P, Ley TJ, Walter MJ, Graubert TA. POU4F1 is associated with t(8;21) acute myeloid leukemia and contributes directly to its unique transcriptional signature. Leukemia. 24: 950-7. PMID 20376082 DOI: 10.1038/leu.2010.61  0.52
2010 White DW, Keppel CR, Schneider SE, Reese TA, Coder J, Payton JE, Ley TJ, Virgin HW, Fehniger TA. Latent herpesvirus infection arms NK cells. Blood. 115: 4377-83. PMID 20139098 DOI: 10.1182/blood-2009-09-245464  0.52
2010 Cai SF, Cao X, Hassan A, Fehniger TA, Ley TJ. Granzyme B is not required for regulatory T cell-mediated suppression of graft-versus-host disease. Blood. 115: 1669-77. PMID 19965675 DOI: 10.1182/blood-2009-07-233676  0.52
2009 Walter MJ, Graubert TA, Dipersio JF, Mardis ER, Wilson RK, Ley TJ. Next-generation sequencing of cancer genomes: back to the future. Personalized Medicine. 6: 653. PMID 20161678 DOI: 10.2217/pme.09.52  0.52
2009 Cao X, Leonard K, Collins LI, Cai SF, Mayer JC, Payton JE, Walter MJ, Piwnica-Worms D, Schreiber RD, Ley TJ. Interleukin 12 stimulates IFN-gamma-mediated inhibition of tumor-induced regulatory T-cell proliferation and enhances tumor clearance. Cancer Research. 69: 8700-9. PMID 19843867 DOI: 10.1158/0008-5472.CAN-09-1145  0.52
2009 Chen K, Wallis JW, McLellan MD, Larson DE, Kalicki JM, Pohl CS, McGrath SD, Wendl MC, Zhang Q, Locke DP, Shi X, Fulton RS, Ley TJ, Wilson RK, Ding L, et al. BreakDancer: an algorithm for high-resolution mapping of genomic structural variation. Nature Methods. 6: 677-81. PMID 19668202 DOI: 10.1038/nmeth.1363  0.52
2009 Mardis ER, Ding L, Dooling DJ, Larson DE, McLellan MD, Chen K, Koboldt DC, Fulton RS, Delehaunty KD, McGrath SD, Fulton LA, Locke DP, Magrini VJ, Abbott RM, Vickery TL, ... ... Ley TJ, et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. The New England Journal of Medicine. 361: 1058-66. PMID 19657110 DOI: 10.1056/NEJMoa0903840  0.52
2009 Walter MJ, Payton JE, Ries RE, Shannon WD, Deshmukh H, Zhao Y, Baty J, Heath S, Westervelt P, Watson MA, Tomasson MH, Nagarajan R, O'Gara BP, Bloomfield CD, Mrózek K, ... ... Ley TJ, et al. Acquired copy number alterations in adult acute myeloid leukemia genomes. Proceedings of the National Academy of Sciences of the United States of America. 106: 12950-5. PMID 19651600 DOI: 10.1073/pnas.0903091106  0.52
2009 Payton JE, Grieselhuber NR, Chang LW, Murakami M, Geiss GK, Link DC, Nagarajan R, Watson MA, Ley TJ. High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples. The Journal of Clinical Investigation. 119: 1714-26. PMID 19451695 DOI: 10.1172/JCI38248  0.52
2009 Cai SF, Fehniger TA, Cao X, Mayer JC, Brune JD, French AR, Ley TJ. Differential expression of granzyme B and C in murine cytotoxic lymphocytes. Journal of Immunology (Baltimore, Md. : 1950). 182: 6287-97. PMID 19414782 DOI: 10.4049/jimmunol.0804333  0.52
2009 Nervi B, Ramirez P, Rettig MP, Uy GL, Holt MS, Ritchey JK, Prior JL, Piwnica-Worms D, Bridger G, Ley TJ, DiPersio JF. Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100. Blood. 113: 6206-14. PMID 19050309 DOI: 10.1182/blood-2008-06-162123  0.52
2008 Ley TJ, Hamilton BH. Sociology. The gender gap in NIH grant applications. Science (New York, N.Y.). 322: 1472-4. PMID 19056961 DOI: 10.1126/science.1165878  0.52
2008 Ley TJ, Mardis ER, Ding L, Fulton B, McLellan MD, Chen K, Dooling D, Dunford-Shore BH, McGrath S, Hickenbotham M, Cook L, Abbott R, Larson DE, Koboldt DC, Pohl C, et al. DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature. 456: 66-72. PMID 18987736 DOI: 10.1038/nature07485  0.52
2008 Funk RK, Maxwell TJ, Izumi M, Edwin D, Kreisel F, Ley TJ, Cheverud JM, Graubert TA. Quantitative trait loci associated with susceptibility to therapy-related acute murine promyelocytic leukemia in hCG-PML/RARA transgenic mice. Blood. 112: 1434-42. PMID 18552208 DOI: 10.1182/blood-2008-01-132084  0.52
2008 Cahan P, Godfrey LE, Eis PS, Richmond TA, Selzer RR, Brent M, McLeod HL, Ley TJ, Graubert TA. wuHMM: a robust algorithm to detect DNA copy number variation using long oligonucleotide microarray data. Nucleic Acids Research. 36: e41. PMID 18334530 DOI: 10.1093/nar/gkn110  0.52
2008 Chang LW, Payton JE, Yuan W, Ley TJ, Nagarajan R, Stormo GD. Computational identification of the normal and perturbed genetic networks involved in myeloid differentiation and acute promyelocytic leukemia. Genome Biology. 9: R38. PMID 18291030 DOI: 10.1186/gb-2008-9-2-r38  0.52
2008 Tomasson MH, Xiang Z, Walgren R, Zhao Y, Kasai Y, Miner T, Ries RE, Lubman O, Fremont DH, McLellan MD, Payton JE, Westervelt P, DiPersio JF, Link DC, Walter MJ, ... ... Ley TJ, et al. Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia. Blood. 111: 4797-808. PMID 18270328 DOI: 10.1182/blood-2007-09-113027  0.52
2008 Xiang Z, Zhao Y, Mitaksov V, Fremont DH, Kasai Y, Molitoris A, Ries RE, Miner TL, McLellan MD, DiPersio JF, Link DC, Payton JE, Graubert TA, Watson M, Shannon W, ... ... Ley TJ, et al. Identification of somatic JAK1 mutations in patients with acute myeloid leukemia. Blood. 111: 4809-12. PMID 18160671 DOI: 10.1182/blood-2007-05-090308  0.52
2007 Cao X, Cai SF, Fehniger TA, Song J, Collins LI, Piwnica-Worms DR, Ley TJ. Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance. Immunity. 27: 635-46. PMID 17919943 DOI: 10.1016/j.immuni.2007.08.014  0.52
2007 Fehniger TA, Cai SF, Cao X, Bredemeyer AJ, Presti RM, French AR, Ley TJ. Acquisition of murine NK cell cytotoxicity requires the translation of a pre-existing pool of granzyme B and perforin mRNAs. Immunity. 26: 798-811. PMID 17540585 DOI: 10.1016/j.immuni.2007.04.010  0.52
2007 Link DC, Kunter G, Kasai Y, Zhao Y, Miner T, McLellan MD, Ries RE, Kapur D, Nagarajan R, Dale DC, Bolyard AA, Boxer LA, Welte K, Zeidler C, Donadieu J, ... ... Ley TJ, et al. Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia. Blood. 110: 1648-55. PMID 17494858 DOI: 10.1182/blood-2007-03-081216  0.52
2007 Graubert TA, Cahan P, Edwin D, Selzer RR, Richmond TA, Eis PS, Shannon WD, Li X, McLeod HL, Cheverud JM, Ley TJ. A high-resolution map of segmental DNA copy number variation in the mouse genome. Plos Genetics. 3: e3. PMID 17206864 DOI: 10.1371/journal.pgen.0030003  0.52
2007 Yuan W, Payton JE, Holt MS, Link DC, Watson MA, DiPersio JF, Ley TJ. Commonly dysregulated genes in murine APL cells. Blood. 109: 961-70. PMID 17008535 DOI: 10.1182/blood-2006-07-036640  0.52
2007 Walter MJ, Ries RE, Armstrong JR, Park JS, Mardis ER, Ley TJ. Expression of a bcr-1 isoform of RARalpha-PML does not affect the penetrance of acute promyelocytic leukemia or the acquisition of an interstitial deletion on mouse chromosome 2. Blood. 109: 1237-40. PMID 17008533 DOI: 10.1182/blood-2006-07-037465  0.52
2006 Bredemeyer AJ, Carrigan PE, Fehniger TA, Smith DF, Ley TJ. Hop cleavage and function in granzyme B-induced apoptosis. The Journal of Biological Chemistry. 281: 37130-41. PMID 17005566 DOI: 10.1074/jbc.M607969200  0.52
2006 Lu ZH, Books JT, Ley TJ. Cold shock domain family members YB-1 and MSY4 share essential functions during murine embryogenesis. Molecular and Cellular Biology. 26: 8410-7. PMID 16954378 DOI: 10.1128/MCB.01196-06  0.52
2006 Chan IT, Kutok JL, Williams IR, Cohen S, Moore S, Shigematsu H, Ley TJ, Akashi K, Le Beau MM, Gilliland DG. Oncogenic K-ras cooperates with PML-RAR alpha to induce an acute promyelocytic leukemia-like disease. Blood. 108: 1708-15. PMID 16675706 DOI: 10.1182/blood-2006-04-015040  0.52
2006 Ley TJ, Rosenberg L. In reply [2] Journal of the American Medical Association. 295: 623-624. DOI: 10.1001/jama.295.6.623-b  0.52
2005 Ley TJ, Rosenberg LE. The physician-scientist career pipeline in 2005: build it, and they will come. Jama. 294: 1343-51. PMID 16174692 DOI: 10.1001/jama.294.11.1343  0.52
2005 Walter MJ, Park JS, Ries RE, Lau SK, McLellan M, Jaeger S, Wilson RK, Mardis ER, Ley TJ. Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RARalpha. Proceedings of the National Academy of Sciences of the United States of America. 102: 12513-8. PMID 16113082 DOI: 10.1073/pnas.0504247102  0.52
2005 Bredemeyer AJ, Townsend RR, Ley TJ. Use of protease proteomics to discover granzyme B substrates. Immunologic Research. 32: 143-53. PMID 16106065 DOI: 10.1385/IR:32:1-3:143  0.52
2005 Pollock JL, Lane AA, Schrimpf K, Ley TJ. Murine acute promyelocytic leukemia cells can be recognized and cleared in vivo by adaptive immune mechanisms. Haematologica. 90: 1042-9. PMID 16079103  0.52
2005 Lu ZH, Books JT, Ley TJ. YB-1 is important for late-stage embryonic development, optimal cellular stress responses, and the prevention of premature senescence. Molecular and Cellular Biology. 25: 4625-37. PMID 15899865 DOI: 10.1128/MCB.25.11.4625-4637.2005  0.52
2005 Ley TJ. Retrospective: Stanley Joel Korsmeyer (1950-2005). Science (New York, N.Y.). 308: 803-4. PMID 15879200 DOI: 10.1126/science.1113842  0.52
2005 Revell PA, Grossman WJ, Thomas DA, Cao X, Behl R, Ratner JA, Lu ZH, Ley TJ. Granzyme B and the downstream granzymes C and/or F are important for cytotoxic lymphocyte functions. Journal of Immunology (Baltimore, Md. : 1950). 174: 2124-31. PMID 15699143  0.52
2005 Lane AA, Ley TJ. Neutrophil elastase is important for PML-retinoic acid receptor alpha activities in early myeloid cells. Molecular and Cellular Biology. 25: 23-33. PMID 15601827 DOI: 10.1128/MCB.25.1.23-33.2005  0.52
2004 Pham CT, Ivanovich JL, Raptis SZ, Zehnbauer B, Ley TJ. Papillon-Lefèvre syndrome: correlating the molecular, cellular, and clinical consequences of cathepsin C/dipeptidyl peptidase I deficiency in humans. Journal of Immunology (Baltimore, Md. : 1950). 173: 7277-81. PMID 15585850  0.52
2004 Walter MJ, Park JS, Lau SK, Li X, Lane AA, Nagarajan R, Shannon WD, Ley TJ. Expression profiling of murine acute promyelocytic leukemia cells reveals multiple model-dependent progression signatures. Molecular and Cellular Biology. 24: 10882-93. PMID 15572690 DOI: 10.1128/MCB.24.24.10882-10893.2004  0.52
2004 Loh J, Thomas DA, Revell PA, Ley TJ, Virgin HW. Granzymes and caspase 3 play important roles in control of gammaherpesvirus latency. Journal of Virology. 78: 12519-28. PMID 15507639 DOI: 10.1128/JVI.78.22.12519-12528.2004  0.52
2004 Grossman WJ, Verbsky JW, Barchet W, Colonna M, Atkinson JP, Ley TJ. Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity. 21: 589-601. PMID 15485635 DOI: 10.1016/j.immuni.2004.09.002  0.52
2004 Bredemeyer AJ, Lewis RM, Malone JP, Davis AE, Gross J, Townsend RR, Ley TJ. A proteomic approach for the discovery of protease substrates. Proceedings of the National Academy of Sciences of the United States of America. 101: 11785-90. PMID 15280543 DOI: 10.1073/pnas.0402353101  0.52
2004 Grossman WJ, Ley TJ. Granzymes A and B are not expressed in human neutrophils. Blood. 104: 906-7; author reply . PMID 15265800 DOI: 10.1182/blood-2004-03-0858  0.52
2004 Grossman WJ, Verbsky JW, Tollefsen BL, Kemper C, Atkinson JP, Ley TJ. Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells. Blood. 104: 2840-8. PMID 15238416 DOI: 10.1182/blood-2004-03-0859  0.52
2003 Wilson RK, Ley TJ, Cole FS, Milbrandt JD, Clifton S, Fulton L, Fewell G, Minx P, Sun H, McLellan M, Pohl C, Mardis ER. Mutational profiling in the human genome. Cold Spring Harbor Symposia On Quantitative Biology. 68: 23-9. PMID 15338599  0.52
2003 Ley TJ. 1998 ASCI Presidential Address. The Journal of Clinical Investigation. 112: S9-11. PMID 14702962  0.52
2003 Lane AA, Ley TJ. Neutrophil elastase cleaves PML-RARalpha and is important for the development of acute promyelocytic leukemia in mice. Cell. 115: 305-18. PMID 14636558 DOI: 10.1016/S0092-8674(03)00852-3  0.52
2003 Ley TJ, Minx PJ, Walter MJ, Ries RE, Sun H, McLellan M, DiPersio JF, Link DC, Tomasson MH, Graubert TA, McLeod H, Khoury H, Watson M, Shannon W, Trinkaus K, et al. A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes. Proceedings of the National Academy of Sciences of the United States of America. 100: 14275-80. PMID 14614138 DOI: 10.1073/pnas.2335924100  0.52
2003 Grossman WJ, Revell PA, Lu ZH, Johnson H, Bredemeyer AJ, Ley TJ. The orphan granzymes of humans and mice. Current Opinion in Immunology. 15: 544-52. PMID 14499263 DOI: 10.1016/S0952-7915(03)00099-2  0.52
2003 Westervelt P, Lane AA, Pollock JL, Oldfather K, Holt MS, Zimonjic DB, Popescu NC, DiPersio JF, Ley TJ. High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARalpha expression. Blood. 102: 1857-65. PMID 12750176 DOI: 10.1182/blood-2002-12-3779  0.52
2003 Lu ZH, Books JT, Kaufman RM, Ley TJ. Long targeting arms do not increase the efficiency of homologous recombination in the beta-globin locus of murine embryonic stem cells. Blood. 102: 1531-3. PMID 12730107 DOI: 10.1182/blood-2003-03-0708  0.52
2003 Johnson H, Scorrano L, Korsmeyer SJ, Ley TJ. Cell death induced by granzyme C. Blood. 101: 3093-101. PMID 12515723 DOI: 10.1182/blood-2002-08-2485  0.52
2002 Westervelt P, Pollock JL, Oldfather KM, Walter MJ, Ma MK, Williams A, DiPersio JF, Ley TJ. Adaptive immunity cooperates with liposomal all-trans-retinoic acid (ATRA) to facilitate long-term molecular remissions in mice with acute promyelocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America. 99: 9468-73. PMID 12077315 DOI: 10.1073/pnas.132657799  0.52
2002 Chessler SD, Egan LW, Gallin EK, Sung NS, Gronski TJ, Ley TJ, Rosenberg LE, Nathan DG. Debt repayment for trainees [5] (multiple letters) New England Journal of Medicine. 346: 2013-2014. PMID 12075069 DOI: 10.1056/NEJM200206203462518  0.52
2002 Kelly LM, Kutok JL, Williams IR, Boulton CL, Amaral SM, Curley DP, Ley TJ, Gilliland DG. PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model. Proceedings of the National Academy of Sciences of the United States of America. 99: 8283-8. PMID 12060771 DOI: 10.1073/pnas.122233699  0.52
2002 Russell JH, Ley TJ. Lymphocyte-mediated cytotoxicity. Annual Review of Immunology. 20: 323-70. PMID 11861606 DOI: 10.1146/annurev.immunol.20.100201.131730  0.52
2002 Ley TJ, Rosenberg LE. Removing career obstacles for young physician-scientists -- loan-repayment programs. The New England Journal of Medicine. 346: 368-72. PMID 11821517 DOI: 10.1056/NEJM200201313460515  0.52
2001 Thomas DA, Scorrano L, Putcha GV, Korsmeyer SJ, Ley TJ. Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK. Proceedings of the National Academy of Sciences of the United States of America. 98: 14985-90. PMID 11752447 DOI: 10.1073/pnas.261581498  0.52
2001 Pollock JL, Westervelt P, Walter MJ, Lane AA, Ley TJ. Mouse models of acute promyelocytic leukemia Current Opinion in Hematology. 8: 206-211. PMID 11561157 DOI: 10.1097/00062752-200107000-00005  0.52
2001 Westervelt P, Brown RA, Adkins DR, Khoury H, Curtin P, Hurd D, Luger SM, Ma MK, Ley TJ, DiPersio JF. Sudden death among patients with acute promyelocytic leukemia treated with arsenic trioxide Blood. 98: 266-271. PMID 11435292 DOI: 10.1182/blood.V98.2.266  0.52
2001 Kaufman RM, Lu ZH, Behl R, Holt JM, Ackers GK, Ley TJ. Lack of neighborhood effects from a transcriptionally active phosphoglycerate kinase-neo cassette located between the murine β-major and β-minor globin genes Blood. 98: 65-73. PMID 11418464 DOI: 10.1182/blood.V98.1.65  0.52
2001 Wolters PJ, Pham CTN, Muilenburg DJ, Ley TJ, Caughey GH. Dipeptidyl Peptidase I is Essential for Activation of Mast Cell Chymases, but Not Tryptases, in Mice Journal of Biological Chemistry. 276: 18551-18556. PMID 11279033 DOI: 10.1074/jbc.M100223200  0.52
2000 Zimonjic DB, Pollock JL, Westervelt P, Popescu NC, Ley TJ. Acquired, nonrandom chromosomal abnormalities associated with the development of acute promyelocytic leukemia in transgenic mice Proceedings of the National Academy of Sciences of the United States of America. 97: 13306-13311. PMID 11087871 DOI: 10.1073/pnas.97.24.13306  0.52
2000 Thomas DA, Du C, Xu M, Wang X, Ley TJ. DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis. Immunity. 12: 621-32. PMID 10894162  0.52
2000 Bender MA, Mehaffey MG, Telling A, Hug B, Ley TJ, Groudine M, Fiering S. Independent formation of DnaseI hypersensitive sites in the murine beta-globin locus control region. Blood. 95: 3600-4. PMID 10828050  0.52
2000 Alami R, Bender MA, Feng YQ, Fiering SN, Hug BA, Ley TJ, Groudine M, Bouhassira EE. Deletions within the mouse beta-globin locus control region preferentially reduce beta(min) globin gene expression. Genomics. 63: 417-24. PMID 10704289 DOI: 10.1006/geno.1999.6104  0.52
2000 Zemlo TR, Garrison HH, Partridge NC, Ley TJ. The physician-scientist: Career issues and challenges at the year 2000 Faseb Journal. 14: 221-230. PMID 10657979  0.52
2000 Lu ZH, Kaufman RM, Holt JM, Ackers G, Ley TJ. Lack of neighborhood effects from a retained pgk-neocassette located between the murine β-major and β-minor globin genes Blood. 96.  0.52
1999 Pollock JL, Westervelt P, Kurichety AK, Pelicci PG, Grisolano JL, Ley TJ. A bcr-3 isoform of RARα-PML potentiates the development of PML-RARα- driven acute promyelocytic leukemia Proceedings of the National Academy of Sciences of the United States of America. 96: 15103-15108. PMID 10611345 DOI: 10.1073/pnas.96.26.15103  0.52
1999 MacIvor DM, Shapiro SD, Pham CTN, Belaaouaj A, Abraham SN, Ley TJ. Normal neutrophil function in cathepsin G-deficient mice Blood. 94: 4282-4293. PMID 10590073  0.52
1999 Kaufman RM, Pham CTN, Ley TJ. Transgenic analysis of a 100-kb human β-globin cluster-containing DNA fragment propagated as a bacterial artificial chromosome Blood. 94: 3178-3184. PMID 10556205  0.52
1999 Pham CTN, Ley TJ. Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo Proceedings of the National Academy of Sciences of the United States of America. 96: 8627-8632. PMID 10411926 DOI: 10.1073/pnas.96.15.8627  0.52
1999 Shresta S, Graubert TA, Thomas DA, Raptis SZ, Ley TJ. Granzyme A initiates an alternative pathway for granule-mediated apoptosis. Immunity. 10: 595-605. PMID 10367905 DOI: 10.1016/S1074-7613(00)80059-X  0.52
1999 Westervelt P, Ley TJ. Seed versus soil: The importance of the target cell for transgenic models of human leukemias Blood. 93: 2143-2148. PMID 10090920  0.52
1999 MacIvor DM, Pham CTN, Ley TJ. The 5' flanking region of the human granzyme H gene directs expression to T/natural killer cell progenitors and lymphokine-activated killer cells in transgenic mice Blood. 93: 963-973. PMID 9920846  0.52
1998 Shresta S, Pham CT, Thomas DA, Graubert TA, Ley TJ. How do cytotoxic lymphocytes kill their targets? Current Opinion in Immunology. 10: 581-7. PMID 9794837 DOI: 10.1016/S0952-7915(98)80227-6  0.52
1998 Abbott RE, Corral CJ, MacIvor DM, Lin X, Ley TJ, Mustoe TA. Augmented inflammatory responses and altered wound healing in cathepsin G-deficient mice Archives of Surgery. 133: 1002-1006. PMID 9749856 DOI: 10.1001/archsurg.133.9.1002  0.52
1998 Ley TJ, Hug B, Fiering S, Epner E, Bender MA, Groudine M. Reduced beta-globin gene expression in adult mice containing deletions of locus control region 5' HS-2 or 5' HS-3. Annals of the New York Academy of Sciences. 850: 45-53. PMID 9668526 DOI: 10.1111/j.1749-6632.1998.tb10461.x  0.52
1998 Graubert TA, Hug BA, Wesselschmidt R, Hsieh CL, Ryan TM, Townes TM, Ley TJ. Stochastic, stage-specific mechanisms account for the variegation of a human globin transgene Nucleic Acids Research. 26: 2849-2858. PMID 9611227 DOI: 10.1093/nar/26.12.2849  0.52
1998 Belaaouaj A, Mccarthy R, Baumann M, Gao Z, Ley TJ, Abraham SN, Shapiro SD. Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis Nature Medicine. 4: 615-618. PMID 9585238 DOI: 10.1038/nm0598-615  0.52
1998 Pham CT, Thomas DA, Mercer JD, Ley TJ. Production of fully active recombinant murine granzyme B in yeast. The Journal of Biological Chemistry. 273: 1629-33. PMID 9430705 DOI: 10.1074/jbc.273.3.1629  0.52
1997 Graubert TA, DiPersio JF, Russell JH, Ley TJ. Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation Journal of Clinical Investigation. 100: 904-911. PMID 9259590  0.52
1997 Shresta S, Goda P, Wesselschmidt R, Ley TJ. Residual cytotoxicity and granzyme K expression in granzyme A-deficient cytotoxic lymphocytes. The Journal of Biological Chemistry. 272: 20236-44. PMID 9242702 DOI: 10.1074/jbc.272.32.20236  0.52
1997 Pham CTN, Ley TJ. The role of granzyme B cluster proteases in cell-mediated cytotoxicity Seminars in Immunology. 9: 127-133. PMID 9194223 DOI: 10.1006/smim.1997.0060  0.52
1997 Shresta S, Russell JH, Ley TJ. Mechanisms responsible for granzyme B-independent cytotoxicity. Blood. 89: 4085-91. PMID 9166849  0.52
1997 Pham CTN, Armstrong RJ, Zimonjie DB, Popescu NC, Payan DG, Ley TJ. Molecular cloning, chromosomal localization, and expression of murine Dipeptidyl peptidase I Journal of Biological Chemistry. 272: 10695-10703. PMID 9099719 DOI: 10.1074/jbc.272.16.10695  0.52
1997 Grisolano JL, Wesselschmidt RL, Pelicci PG, Ley TJ. Altered myeloid development and acute leukemia in transgenic mice expressing PML-RARα under control of cathepsin G regulatory sequences Blood. 89: 376-387. PMID 9002938  0.52
1996 Graubert TA, Ley TJ. How do lymphocytes kill tumor cells? Clinical Cancer Research. 2: 785-789. PMID 9816231  0.52
1996 Grisolano JL, Ley TJ. Regulation of azurophil granule-associated serine protease genes during myelopoiesis Current Opinion in Hematology. 3: 55-62. PMID 9372052  0.52
1996 Pham CTN, Macivor DM, Hug BA, Heusel JW, Ley TJ. Long-range disruption of gene expression by a selectable marker cassette Proceedings of the National Academy of Sciences of the United States of America. 93: 13090-13095. PMID 8917549 DOI: 10.1073/pnas.93.23.13090  0.52
1996 Darmon AJ, Ley TJ, Nicholson DW, Bleackley RC. Cleavage of CPP32 by granzyme B represents a critical role for granzyme B in the induction of target cell DNA fragmentation. The Journal of Biological Chemistry. 271: 21709-12. PMID 8702964 DOI: 10.1074/jbc.271.36.21709  0.52
1996 Hug BA, Wesselschmidt RL, Fiering S, Bender MA, Epner E, Groudine M, Ley TJ. Analysis of mice containing a targeted deletion of beta-globin locus control region 5' hypersensitive site 3. Molecular and Cellular Biology. 16: 2906-12. PMID 8649401  0.52
1996 Shipley JM, Wesselschmidt RL, Kobayashi DK, Ley TJ, Shapiro SD. Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice Proceedings of the National Academy of Sciences of the United States of America. 93: 3942-3946. PMID 8632994 DOI: 10.1073/pnas.93.9.3942  0.52
1996 Graubert TA, Russell JH, Ley TJ. The role of granzyme B in murine models of acute graft-versus-host disease and graft rejection Blood. 87: 1232-1237. PMID 8608209  0.52
1995 Grossman WJ, Kimata JT, Wong FH, Zutter M, Ley TJ, Ratner L. Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I Proceedings of the National Academy of Sciences of the United States of America. 92: 1057-1061. PMID 7862633  0.52
1995 Shresta S, MacIvor DM, Heusel JW, Russell JH, Ley TJ. Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells. Proceedings of the National Academy of Sciences of the United States of America. 92: 5679-83. PMID 7777569 DOI: 10.1073/pnas.92.12.5679  0.52
1995 Bacolla A, Ulrich MJ, Larson JE, Ley TJ, Wells RD. An intramolecular triplex in the human gamma-globin 5'-flanking region is altered by point mutations associated with hereditary persistence of fetal hemoglobin. The Journal of Biological Chemistry. 270: 24556-63. PMID 7592674  0.52
1995 Fiering S, Epner E, Robinson K, Zhuang Y, Telling A, Hu M, Martin DIK, Enver T, Ley TJ, Groudine M. Targeted deletion of 5′HS2 of the murine β-globin LCR reveals that it is not essential for proper regulation of the β-globin locus Genes and Development. 9: 2203-2213. PMID 7557375  0.52
1995 Shresta S, Heusel JW, Macivor DM, Wesselschmidt RL, Russell JH, Ley TJ. Granzyme B plays a critical role in cytotoxic lymphocyte-induced apoptosis. Immunological Reviews. 146: 211-21. PMID 7493755  0.52
1994 Horwitz EM, Maloney KA, Ley TJ. A human protein containing a "cold shock" domain binds specifically to H-DNA upstream from the human γ-globin genes Journal of Biological Chemistry. 269: 14130-14139. PMID 8188694  0.52
1994 Heusel JW, Wesselschmidt RL, Shresta S, Russell JH, Ley TJ. Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell. 76: 977-87. PMID 8137431 DOI: 10.1016/0092-8674(94)90376-X  0.52
1994 Grisolano JL, Sclar GM, Ley TJ. Early myeloid cell-specific expression of the human cathepsin G gene in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 91: 8989-93. PMID 8090757 DOI: 10.1073/pnas.91.19.8989  0.52
1993 Shapiro SD, Doyle GAR, Ley TJ, Parks WC, Welgus HG. Molecular mechanisms regulating the production of collagenase and TIMP in U937 cells: Evidence for involvement of delayed transcriptional activation and enhanced mRNA stability Biochemistry. 32: 4286-4292. PMID 8476858  0.52
1993 Caughey GH, Schaumberg TH, Zerweck EH, Butterfield JH, Hanson RD, Silverman GA, Ley TJ. The Human Mast Cell Chymase Gene (CMA1): Mapping to the Cathepsin G/Granzyme Gene Cluster and Lineage-Restricted Expression Genomics. 15: 614-620. PMID 8468056 DOI: 10.1006/geno.1993.1115  0.52
1993 Heusel JW, Scarpati EM, Jenkins NA, Gilbert DJ, Copeland NG, Shapiro SD, Ley TJ. Molecular cloning, chromosomal location, and tissue-specific expression of the murine cathepsin G gene. Blood. 81: 1614-23. PMID 8453108  0.52
1993 Shapiro SD, Kobayashi DK, Ley TJ. Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages. The Journal of Biological Chemistry. 268: 23824-9. PMID 8226919  0.52
1993 Hanson RD, Grisolano JL, Ley TJ. Consensus AP-1 and CRE motifs upstream from the human cytotoxic serine protease B (CSP-B/CGL-1) gene synergize to activate transcription Blood. 82: 2749-2757. PMID 8219227  0.52
1992 Hanson RD, Ley TJ. A-T-rich scaffold attachment regions flank the hematopoietic serine protease genes clustered on chromosome 14q11.2 Blood. 79: 610-618. PMID 1732006  0.52
1992 Shapiro SD, Griffin GL, Gilbert DJ, Jenkins NA, Copeland NG, Welgus HG, Senior RM, Ley TJ. Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase. The Journal of Biological Chemistry. 267: 4664-71. PMID 1537850  0.52
1992 Welgus HG, Senior RM, Parks WC, Kahn AJ, Ley TJ, Shapiro SD, Campbell EJ. Neutral proteinase expression by human mononuclear phagocytes: a prominent role of cellular differentiation. Matrix (Stuttgart, Germany). Supplement. 1: 363-7. PMID 1480061  0.52
1992 Hug BA, Moon AM, Ley TJ. Structure and function of the murine β-globin locus control region 5′ HS-3 Nucleic Acids Research. 20: 5771-5778. PMID 1454538 DOI: 10.1093/nar/20.21.5771  0.52
1992 Ulrich MJ, Gray WJ, Ley TJ. An intramolecular DNA triplex is disrupted by point mutations associated with hereditary persistence of fetal hemoglobin Journal of Biological Chemistry. 267: 18649-18658. PMID 1382059  0.52
1992 Link DC, Gutkind SJ, Robbins KC, Ley TJ. Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter Oncogene. 7: 877-884. PMID 1373875  0.52
1991 Heusel JW, Hanson RD, Silverman GA, Ley TJ. Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2 Journal of Biological Chemistry. 266: 6152-6158. PMID 2007574  0.52
1991 Gutkind JS, Link DC, Katamine S, Lacal P, Miki T, Ley TJ, Robbins KC. A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes Molecular and Cellular Biology. 11: 1500-1507. PMID 1847500  0.52
1991 Hanson RD, Sclar GM, Kanagawa O, Ley TJ. The 5'-flanking region of the human CGL-1/granzyme B gene targets expression of a reporter gene to activated T-lymphocytes in transgenic mice. The Journal of Biological Chemistry. 266: 24433-8. PMID 1761544  0.52
1991 Moon AM, Ley TJ. Functional properties of the β-globin locus control region in K562 erythroleukemia cells Blood. 77: 2272-2284. PMID 1709381  0.52
1991 Ley TJ. The pharmacology of hemoglobin switching: Of mice and men Blood. 77: 1146-1152. PMID 1705828  0.52
1991 Perkins SL, Link DC, Kling S, Ley TJ, Teitelbaum SL. 1,25-Dihydroxyvitamin D3 induces monocytic differentiation of the PLB-985 leukemic line and promotes c-fgr mRNA expression Journal of Leukocyte Biology. 50: 427-433. PMID 1660912  0.52
1990 Hanson RD, Hohn PA, Popescu NC, Ley TJ. A cluster of hematopoietic serine protease genes is found on the same chromosomal band as the human α/δ T-cell receptor locus Proceedings of the National Academy of Sciences of the United States of America. 87: 960-963. PMID 2300587  0.52
1990 Hanson RD, Connolly NL, Burnett D, Campbell EJ, Senior RM, Ley TJ. Developmental regulation of the human cathepsin G gene in myelomonocytic cells. The Journal of Biological Chemistry. 265: 1524-30. PMID 2295643  0.52
1990 Ulrich MJ, Moon AM, Ley TJ. Function of transfected globin promoters and the globin locus activator in K562 erythroleukemia cells Annals of the New York Academy of Sciences. 612: 207-214. PMID 2291547 DOI: 10.1111/j.1749-6632.1990.tb24308.x  0.52
1990 Hanson RD, Ley TJ. Transcriptional activation of the human cytotoxic serine protease gene CSP-B in T lymphocytes Molecular and Cellular Biology. 10: 5655-5662. PMID 2233710  0.52
1990 Moon AM, Ley TJ. Conservation of the primary structure, organization, and function of the human and mouse β-globin locus-activating regions Proceedings of the National Academy of Sciences of the United States of America. 87: 7693-7697. PMID 2217202  0.52
1990 Ulrich MJ, Ley TJ. Function of normal and mutated γ-globin gene promoters in electroporated K562 erythroleukemia cells Blood. 75: 990-999. PMID 1689192  0.52
1989 Ley TJ, Maloney KA, Gordon JI, Schwartz AL. Globin gene expression in erythroid human fetal liver cells Journal of Clinical Investigation. 83: 1032-1038. PMID 2921315  0.52
1989 Rebbe NF, Hickman WS, Ley TJ, Stafford DW, Hickman S. Nucleotide sequence and regulation of a human 90-kDa heat shock protein gene Journal of Biological Chemistry. 264: 15006-15011. PMID 2768249  0.52
1989 Hohn PA, Popescu NC, Hanson RD, Salvesen G, Ley TJ. Genomic organization and chromosomal localization of the human cathepsin G gene Journal of Biological Chemistry. 264: 13412-13419. PMID 2569462  0.52
1989 Ley TJ, Connolly NL, Katamine S, Cheah MS, Senior RM, Robbins KC. Tissue-specific expression and developmental regulation of the human fgr proto-oncogene. Molecular and Cellular Biology. 9: 92-9. PMID 2538725  0.52
1989 Lin HJ, Bodine DM, Rutherford TR, Anagnou NP, McDonagh KT, Ley TJ, Nienhuis AW. Regulatory regions flanking the human fetal γ-globin genes Annals of the New York Academy of Sciences. 565: 13-22. PMID 2476058 DOI: 10.1111/j.1749-6632.1989.tb24145.x  0.52
1989 Carel JC, Frazier B, Ley TJ, Holers VM. Analysis of epitope expression and the functional repertoire of recombinant complement receptor 2 (CR2/CD21) in mouse and human cells Journal of Immunology. 143: 923-930. PMID 2473114  0.52
1988 Gimble JM, Max EE, Ley TJ. High-resolution analysis of the human γ-globin gene promoter in K562 erythroleukemia cell chromatin Blood. 72: 606-612. PMID 3165297  0.52
1987 Bodine DM, Ley TJ. An enhancer element lies 3' to the human A gamma globin gene Embo Journal. 6: 2997-3004. PMID 3691478  0.52
1987 Bodine DM, Ley TJ. A transient assay system to study gamma globin gene expression in K562 cells Progress in Clinical and Biological Research. 251: 189-200. PMID 3432267  0.52
1986 Cheah MS, Ley TJ, Tronick SR, Robbins KC. Induction of fgr proto-oncogene mRNA in B lymphocytes as a consequence of Epstein-Barr virus infection Current Topics in Microbiology and Immunology. 132: 237-245. PMID 3024916  0.52
1986 Cheah MSC, Ley TJ, Tronick SR, Robbins KC. fgr proto-oncogene mRNA induced in B lymphocytes by Epstein-Barr virus infection Nature. 319: 238-240. PMID 3003578  0.52
1986 Dover GJ, Humphries RK, Moore JG, Ley TJ, Young NS, Charache S, Nienhuis AW. Hydroxyurea induction of hemoglobin F production in sickle cell disease: Relationship between cytotoxicity and F cell production Blood. 67: 735-738. PMID 2418898  0.52
1985 Ley TJ, Nienhuis AW. Induction of hemoglobin F synthesis in patients with beta thalassemia Annual Review of Medicine. 36: 485-498. PMID 2581500  0.52
1985 Sands JM, Macher AM, Ley TJ, Nienhuis AW. Disseminated infection caused by Cunninghamella bertholletiae in a patient with beta-thalassemia. Case report and review of the literature Annals of Internal Medicine. 102: 59-63. PMID 2578267  0.52
1985 Nienhuis AW, Ley TJ, Humphries RK. Pharmacological manipulation of fetal hemoglobin synthesis in patients with severe β-thalassemia Annals of the New York Academy of Sciences. 198-211. PMID 2409872  0.52
1984 Humphries RK, Ley TJ, Anagnou NP. β0-39 thalassemia gene: A premature termination codon causes β-mRNA deficiency without affecting cytoplasmic β-mRNA stability Blood. 64: 23-32. PMID 6733274  0.52
1984 Chiang YL, Ley TJ, Sanders-Haigh L, Anderson WF. Human globin gene expression in hybrid 2S MEL X human fibroblast cells. Somatic Cell and Molecular Genetics. 10: 399-407. PMID 6589792 DOI: 10.1007/BF01535635  0.52
1984 Ley TJ, Chiang YL, Haidaris D, Anagnou NP, Wilson VL, Anderson WF. DNA methylation and regulation of the human beta-globin-like genes in mouse erythroleukemia cells containing human chromosome 11. Proceedings of the National Academy of Sciences of the United States of America. 81: 6618-22. PMID 6208553 DOI: 10.1073/pnas.81.21.6618  0.52
1984 Nienhuis AW, Anagnou NP, Ley TJ. Advances in thalassemia research Blood. 63: 738-758. PMID 6200160  0.52
1983 Ley TJ, Nienhuis AW. Chelation therapy for transfusion-dependent adults New England Journal of Medicine. 308: 1422-1423. PMID 6843638  0.52
1983 Dean A, Ley TJ, Humphries RK, Fordis CM, Schechter AN. Abundance and structure of globin mRNA in K562 human leukemia cells Progress in Clinical and Biological Research. 134: 323-334. PMID 6686681  0.52
1983 Anderson WF, Chiang YL, Sanders-Haigh L, Ley TJ. Globin gene expression in somatic cell hybrids. Progress in Clinical and Biological Research. 134: 39-52. PMID 6320217  0.52
1983 Dean A, Ley TJ, Humphries RK, Fordis M, Schechter AN. Inducible transcription of five globin genes in K562 human leukemia cells Proceedings of the National Academy of Sciences of the United States of America. 80: 5515-5519. PMID 6310580  0.52
1983 Ley TJ, Nienhuis AW. A weak upstream promoter gives rise to long human β-globin RNA molecules Biochemical and Biophysical Research Communications. 112: 1041-1048. PMID 6303333 DOI: 10.1016/0006-291X(83)91723-0  0.52
1983 Ley TJ, Anagnou NP, Noguchi CT, Schechter AN, DeSimone J, Heller P, Nienhuis AW. DNA methylation and globin gene expression in patients treated with 5-azacytidine Progress in Clinical and Biological Research. 134: 457-474. PMID 6198660  0.52
1983 Ley TJ, DeSimone J, Noguchi CT, Turner PH, Schechter AN, Heller P, Nienhuis AW. 5-Azacytidine increases γ-globin synthesis and reduces the proportion of dense cells in patients with sickle cell anemia Blood. 62: 370-380. PMID 6191799  0.52
1983 Anagnou NP, Ley TJ, Chesbro B, Wright G, Kitchens C, Liebhaber S, Nienhuis AW, Deisseroth AB. Acquired α-thalassemia in preleukemia is due to decreased expression of all four α-globin genes Proceedings of the National Academy of Sciences of the United States of America. 80: 6051-6055. PMID 6136971  0.52
1982 Ley TJ, Griffith P, Nienhuis AW. Transfusion haemosiderosis and chelation therapy Clinics in Haematology. 11: 437-464. PMID 7042160  0.52
1982 Ley TJ, Anagnou NP, Pepe G, Nienhuis AW. RNA processing errors in patients with beta-thalassemia Proceedings of the National Academy of Sciences of the United States of America. 79: 4775-4779. PMID 6956887  0.52
1982 Ley TJ, DeSimone J, Anagnou NP, Keller GH, Humphries RK, Turner PH, Young NS, Keller P, Nienhuis AW. 5-Azacytidine selectively increases γ-globin synthesis in a patient with β + thalassemia New England Journal of Medicine. 307: 1469-1475. PMID 6183586  0.52
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