Shin-ichiro Imai - Publications

Affiliations: 
Biology & Biomedical Sciences (Molecular Cell Biology) Washington University, Saint Louis, St. Louis, MO 
Area:
Neuroscience Biology, Cell Biology, Aging

53 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Whitson JA, Bitto A, Zhang H, Sweetwyne MT, Coig R, Bhayana S, Shankland EG, Wang L, Bammler TK, Mills KF, Imai SI, Conley KE, Marcinek DJ, Rabinovitch PS. SS-31 and NMN: Two paths to improve metabolism and function in aged hearts. Aging Cell. e13213. PMID 32779818 DOI: 10.1111/acel.13213  0.48
2019 Grozio A, Mills K, Yoshino J, Bruzzone S, Sociali G, Tokizane K, Lei HC, Sasaki Y, Migaud M, Imai SI. Reply to: Absence of evidence that Slc12a8 encodes a nicotinamide mononucleotide transporter. Nature Metabolism. 1: 662-665. PMID 32694650 DOI: 10.1038/s42255-019-0086-z  0.36
2019 Grozio A, Mills KF, Yoshino J, Bruzzone S, Sociali G, Tokizane K, Lei HC, Cunningham R, Sasaki Y, Migaud ME, Imai SI. Author Correction: Slc12a8 is a nicotinamide mononucleotide transporter. Nature Metabolism. 1: 743. PMID 32694647 DOI: 10.1038/s42255-019-0088-x  0.48
2019 Yoshida M, Satoh A, Lin JB, Mills KF, Sasaki Y, Rensing N, Wong M, Apte RS, Imai SI. Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice. Cell Metabolism. PMID 31204283 DOI: 10.1016/j.cmet.2019.05.015  0.48
2019 Grozio A, Mills KF, Yoshino J, Bruzzone S, Sociali G, Tokizane K, Lei HC, Cunningham R, Sasaki Y, Migaud ME, Imai SI. Slc12a8 is a nicotinamide mononucleotide transporter. Nature Metabolism. 1: 47-57. PMID 31131364 DOI: 10.1038/s42255-018-0009-4  0.48
2017 Yoshino J, Baur JA, Imai SI. NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metabolism. PMID 29249689 DOI: 10.1016/j.cmet.2017.11.002  0.36
2016 Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI. Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell Metabolism. 24: 795-806. PMID 28068222 DOI: 10.1016/j.cmet.2016.09.013  0.48
2016 Lin JB, Kubota S, Ban N, Yoshida M, Santeford A, Sene A, Nakamura R, Zapata N, Kubota M, Tsubota K, Yoshino J, Imai S, Apte RS. NAMPT-Mediated NAD(+) Biosynthesis Is Essential for Vision In Mice. Cell Reports. 17: 69-85. PMID 27681422 DOI: 10.1016/j.celrep.2016.08.073  0.36
2016 Stromsdorfer KL, Yamaguchi S, Yoon MJ, Moseley AC, Franczyk MP, Kelly SC, Qi N, Imai SI, Yoshino J. NAMPT-Mediated NAD(+) Biosynthesis in Adipocytes Regulates Adipose Tissue Function and Multi-organ Insulin Sensitivity in Mice. Cell Reports. PMID 27498863 DOI: 10.1016/j.celrep.2016.07.027  0.36
2016 de Picciotto NE, Gano LB, Johnson LC, Martens CR, Sindler AL, Mills KF, Imai SI, Seals DR. Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice. Aging Cell. PMID 26970090 DOI: 10.1111/acel.12461  0.48
2015 Stein LR, Zorumski CF, Imai SI, Izumi Y. Nampt is required for long-term depression and the function of GluN2B subunit-containing NMDA receptors. Brain Research Bulletin. PMID 26481044 DOI: 10.1016/j.brainresbull.2015.10.005  0.64
2015 Yoon MJ, Yoshida M, Johnson S, Takikawa A, Usui I, Tobe K, Nakagawa T, Yoshino J, Imai S. SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD+ and Function in Mice. Cell Metabolism. 21: 706-17. PMID 25921090 DOI: 10.1016/j.cmet.2015.04.002  0.64
2015 Ghisays F, Brace CS, Yackly SM, Kwon HJ, Mills KF, Kashentseva E, Dmitriev IP, Curiel DT, Imai SI, Ellenberger T. The N-Terminal Domain of SIRT1 Is a Positive Regulator of Endogenous SIRT1-Dependent Deacetylation and Transcriptional Outputs. Cell Reports. PMID 25772354 DOI: 10.1016/j.celrep.2015.02.036  0.64
2015 Satoh A, Brace CS, Rensing N, Imai S. Deficiency of Prdm13, a dorsomedial hypothalamus-enriched gene, mimics age-associated changes in sleep quality and adiposity. Aging Cell. 14: 209-18. PMID 25546159 DOI: 10.1111/acel.12299  0.64
2014 Satoh A, Imai S. Systemic regulation of mammalian ageing and longevity by brain sirtuins. Nature Communications. 5: 4211. PMID 24967620 DOI: 10.1038/ncomms5211  0.64
2014 Yoshino J, Almeda-Valdes P, Patterson BW, Okunade AL, Imai S, Mittendorfer B, Klein S. Diurnal variation in insulin sensitivity of glucose metabolism is associated with diurnal variations in whole-body and cellular fatty acid metabolism in metabolically normal women. The Journal of Clinical Endocrinology and Metabolism. 99: E1666-70. PMID 24878055 DOI: 10.1210/jc.2014-1579  0.64
2014 Stein LR, Imai S. Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging. The Embo Journal. 33: 1321-40. PMID 24811750 DOI: 10.1002/embj.201386917  0.64
2014 Imai S, Guarente L. NAD+ and sirtuins in aging and disease. Trends in Cell Biology. 24: 464-71. PMID 24786309 DOI: 10.1016/j.tcb.2014.04.002  0.64
2014 Stein LR, Wozniak DF, Dearborn JT, Kubota S, Apte RS, Izumi Y, Zorumski CF, Imai S. Expression of Nampt in hippocampal and cortical excitatory neurons is critical for cognitive function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 5800-15. PMID 24760840 DOI: 10.1523/JNEUROSCI.4730-13.2014  0.64
2014 Satoh A, Imai S. Hypothalamic Sirt1 in aging. Aging. 6: 1-2. PMID 24398359  0.64
2013 Yoshino J, Imai S. Accurate measurement of nicotinamide adenine dinucleotide (NAD⁺) with high-performance liquid chromatography. Methods in Molecular Biology (Clifton, N.J.). 1077: 203-15. PMID 24014409 DOI: 10.1007/978-1-62703-637-5_14  0.64
2013 Satoh A, Brace CS, Rensing N, Cliften P, Wozniak DF, Herzog ED, Yamada KA, Imai S. Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH. Cell Metabolism. 18: 416-30. PMID 24011076 DOI: 10.1016/j.cmet.2013.07.013  0.64
2013 Imai S. [The sirtuin family : regulators that connect metabolism, aging, and longevity]. Clinical Calcium. 23: 29-38. PMID 23268299  0.64
2012 Yoshino J, Conte C, Fontana L, Mittendorfer B, Imai S, Schechtman KB, Gu C, Kunz I, Rossi Fanelli F, Patterson BW, Klein S. Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance. Cell Metabolism. 16: 658-64. PMID 23102619 DOI: 10.1016/j.cmet.2012.09.015  0.36
2011 Yoshino J, Imai S. Mitochondrial SIRT3: a new potential therapeutic target for metabolic syndrome. Molecular Cell. 44: 170-1. PMID 22017865 DOI: 10.1016/j.molcel.2011.10.005  0.36
2011 Yoshino J, Mills KF, Yoon MJ, Imai S. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metabolism. 14: 528-36. PMID 21982712 DOI: 10.1016/j.cmet.2011.08.014  0.64
2011 Imai S. Dissecting systemic control of metabolism and aging in the NAD World: the importance of SIRT1 and NAMPT-mediated NAD biosynthesis. Febs Letters. 585: 1657-62. PMID 21550345 DOI: 10.1016/j.febslet.2011.04.060  0.64
2011 Grimm AA, Brace CS, Wang T, Stormo GD, Imai S. A nutrient-sensitive interaction between Sirt1 and HNF-1α regulates Crp expression. Aging Cell. 10: 305-17. PMID 21176092 DOI: 10.1111/j.1474-9726.2010.00667.x  0.64
2010 Olesen UH, Petersen JG, Garten A, Kiess W, Yoshino J, Imai SI, Christensen MK, Fristrup P, Thougaard AV, Björkling F, Jensen PB, Nielsen SJ, Sehested M. Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase Bmc Cancer. 10. PMID 21144000 DOI: 10.1186/1471-2407-10-677  0.64
2010 Imai S. Toward productive aging: SIRT1, systemic NAD biosynthesis, and the NAD world. Cornea. 29: S7-12. PMID 20935547 DOI: 10.1097/ICO.0b013e3181ea4714  0.64
2010 Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R, Deng C, Dimmeler S, Gius D, Guarente LP, Helfand SL, Imai S, Itoh H, Kadowaki T, Koya D, et al. Dietary restriction: standing up for sirtuins. Science (New York, N.Y.). 329: 1012-3; author reply. PMID 20798296 DOI: 10.1126/science.329.5995.1012  0.64
2010 Yoshino J, Imai S. A clock ticks in pancreatic beta cells. Cell Metabolism. 12: 107-8. PMID 20674854 DOI: 10.1016/j.cmet.2010.07.006  0.36
2010 Satoh A, Brace CS, Ben-Josef G, West T, Wozniak DF, Holtzman DM, Herzog ED, Imai S. SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 10220-32. PMID 20668205 DOI: 10.1523/JNEUROSCI.1385-10.2010  0.64
2010 Imai S, Guarente L. Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases. Trends in Pharmacological Sciences. 31: 212-20. PMID 20226541 DOI: 10.1016/j.tips.2010.02.003  0.64
2010 Imai S. A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis. Pharmacological Research. 62: 42-7. PMID 20085812 DOI: 10.1016/j.phrs.2010.01.006  0.64
2010 Imai S. "Clocks" in the NAD World: NAD as a metabolic oscillator for the regulation of metabolism and aging. Biochimica Et Biophysica Acta. 1804: 1584-90. PMID 19897060 DOI: 10.1016/j.bbapap.2009.10.024  0.64
2009 Imai S. SIRT1 and caloric restriction: an insight into possible trade-offs between robustness and frailty. Current Opinion in Clinical Nutrition and Metabolic Care. 12: 350-6. PMID 19474721 DOI: 10.1097/MCO.0b013e32832c932d  0.64
2009 Ramsey KM, Yoshino J, Brace CS, Abrassart D, Kobayashi Y, Marcheva B, Hong HK, Chong JL, Buhr ED, Lee C, Takahashi JS, Imai S, Bass J. Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science (New York, N.Y.). 324: 651-4. PMID 19299583 DOI: 10.1126/science.1171641  0.64
2009 Imai S. From heterochromatin islands to the NAD World: a hierarchical view of aging through the functions of mammalian Sirt1 and systemic NAD biosynthesis. Biochimica Et Biophysica Acta. 1790: 997-1004. PMID 19289152 DOI: 10.1016/j.bbagen.2009.03.005  0.64
2009 Imai S. Nicotinamide phosphoribosyltransferase (Nampt): a link between NAD biology, metabolism, and diseases. Current Pharmaceutical Design. 15: 20-8. PMID 19149599 DOI: 10.2174/138161209787185814  0.64
2009 Imai S. The NAD World: a new systemic regulatory network for metabolism and aging--Sirt1, systemic NAD biosynthesis, and their importance. Cell Biochemistry and Biophysics. 53: 65-74. PMID 19130305 DOI: 10.1007/s12013-008-9041-4  0.64
2008 Li Y, Zhang Y, Dorweiler B, Cui D, Wang T, Woo CW, Brunkan CS, Wolberger C, Imai S, Tabas I. Extracellular Nampt promotes macrophage survival via a nonenzymatic interleukin-6/STAT3 signaling mechanism. The Journal of Biological Chemistry. 283: 34833-43. PMID 18945671 DOI: 10.1074/jbc.M805866200  0.64
2008 Ramsey KM, Mills KF, Satoh A, Imai SI. Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice Aging Cell. 7: 78-88. PMID 18005249 DOI: 10.1111/j.1474-9726.2007.00355.x  0.64
2007 Revollo JR, Körner A, Mills KF, Satoh A, Wang T, Garten A, Dasgupta B, Sasaki Y, Wolberger C, Townsend RR, Milbrandt J, Kiess W, Imai S. Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. Cell Metabolism. 6: 363-75. PMID 17983582 DOI: 10.1016/j.cmet.2007.09.003  0.64
2007 Imai S. Is Sirt1 a miracle bullet for longevity? Aging Cell. 6: 735-7. PMID 17941969 DOI: 10.1111/j.1474-9726.2007.00344.x  0.64
2007 Revollo JR, Grimm AA, Imai S. The regulation of nicotinamide adenine dinucleotide biosynthesis by Nampt/PBEF/visfatin in mammals. Current Opinion in Gastroenterology. 23: 164-70. PMID 17268245 DOI: 10.1097/MOG.0b013e32801b3c8f  0.64
2006 Wang T, Zhang X, Bheda P, Revollo JR, Imai S, Wolberger C. Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme. Nature Structural & Molecular Biology. 13: 661-2. PMID 16783373 DOI: 10.1038/nsmb1114  0.64
2006 Moynihan KA, Imai Si. Sirt1 as a key regulator orchestrating the response to caloric restriction Drug Discovery Today: Disease Mechanisms. 3: 11-17. DOI: 10.1016/j.ddmec.2006.02.005  0.64
2005 Moynihan KA, Grimm AA, Plueger MM, Bernal-Mizrachi E, Ford E, Cras-Méneur C, Permutt MA, Imai S. Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. Cell Metabolism. 2: 105-17. PMID 16098828 DOI: 10.1016/j.cmet.2005.07.001  0.64
2004 Revollo JR, Grimm AA, Imai S. The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. The Journal of Biological Chemistry. 279: 50754-63. PMID 15381699 DOI: 10.1074/jbc.M408388200  0.64
2001 Vaziri H, Dessain SK, Eaton EN, Imai SI, Frye RA, Pandita TK, Guarente L, Weinberg RA. hSIR2SIRT1 functions as an NAD-dependent p53 deacetylase Cell. 107: 149-159. PMID 11672523 DOI: 10.1016/S0092-8674(01)00527-X  0.64
2001 Luo J, Nikolaev AY, Imai S, Chen D, Su F, Shiloh A, Guarente L, Gu W. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell. 107: 137-48. PMID 11672522 DOI: 10.1016/S0092-8674(01)00524-4  0.64
2000 Imai S, Johnson FB, Marciniak RA, McVey M, Park PU, Guarente L. Sir2: an NAD-dependent histone deacetylase that connects chromatin silencing, metabolism, and aging. Cold Spring Harbor Symposia On Quantitative Biology. 65: 297-302. PMID 12760043  0.64
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