John Y. Shyy - Publications

Biochemistry and Molecular Biology University of California, Riverside, Riverside, CA, United States 

104 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Li J, Wei Q, McCowen KC, Xiong W, Liu J, Jiang W, Thomas RL, Hepokoski M, He M, Shyy JYJ, Malhotra A, Xiong N, Li WX. Inpatient use of metformin and acarbose is associated with reduced mortality of COVID-19 patients with type 2 diabetes mellitus. Endocrinology, Diabetes & Metabolism. e00301. PMID 34585841 DOI: 10.1002/edm2.301  1
2021 Lopez-Ramirez MA, McCurdy S, Li W, Haynes MK, Hale P, Francisco K, Oukoloff K, Bautista M, Choi CHJ, Sun H, Gongol B, Shyy JY, Ballatore C, Sklar LA, Gingras AR. Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells. Faseb Bioadvances. 3: 334-355. PMID 33977234 DOI: 10.1096/fba.2020-00141  1
2020 Pang ZD, Wang Y, Song Z, She G, Ma XZ, Sun X, Wu W, Lai BC, Zhang J, Zhang Y, Du XJ, Shyy JYJ, Deng XL. AMPK upregulates K2.3 channels and ameliorates endothelial dysfunction in diet-induced obese mice. Biochemical Pharmacology. 114337. PMID 33186592 DOI: 10.1016/j.bcp.2020.114337  1
2020 Malhotra A, Hepokoski M, McCowen KC, Shyy JY. ACE2, Metformin, and COVID-19. Iscience. 23: 101425. PMID 32818905 DOI: 10.1016/J.Isci.2020.101425  0.36
2020 Shen H, Zhang J, Wang C, Jain PP, Xiong M, Shi X, Lei Y, Chen S, Yin Q, Thistlethwaite PA, Wang J, Gong K, Yuan ZY, Yuan JX, Shyy JY. MDM2-Mediated Ubiquitination of ACE2 Contributes to the Development of Pulmonary Arterial Hypertension. Circulation. PMID 32755395 DOI: 10.1161/Circulationaha.120.048191  1
2020 Zhang J, He Y, Yan X, Chen S, He M, Lei Y, Zhang J, Gongol B, Gu M, Miao Y, Bai L, Cui X, Wang X, Zhang Y, Fan F, ... ... Shyy JY, et al. MicroRNA-483 amelioration of experimental pulmonary hypertension. Embo Molecular Medicine. e11303. PMID 32324970 DOI: 10.15252/Emmm.201911303  1
2020 Song S, Babicheva A, Zhao T, Ayon RJ, Rodriguez M, Rahimi S, Balistrieri F, Harrington A, Shyy JY, Thistlethwaite PA, Makino A, Yuan JX. Notch Enhances Ca Entry by Activating Calcium-sensing Receptors and Inhibiting Voltage-gated K Channels. American Journal of Physiology. Cell Physiology. PMID 32186932 DOI: 10.1152/Ajpcell.00487.2019  1
2019 Gongol B, Marin T, Zhang J, Wang SC, Sun W, He M, Chen S, Chen L, Li J, Liu JH, Martin M, Han Y, Kang J, Johnson DA, Lytle C, ... ... Shyy JY, et al. Shear stress regulation of miR-93 and miR-484 maturation through nucleolin. Proceedings of the National Academy of Sciences of the United States of America. PMID 31182601 DOI: 10.1073/Pnas.1902844116  1
2019 He M, Huang TS, Li S, Hong HC, Chen Z, Martin M, Zhou X, Huang HY, Su SH, Zhang J, Wang WT, Kang J, Huang HD, Zhang J, Chien S, ... Shyy JY, et al. Atheroprotective Flow Upregulates ITPR3 (Inositol 1,4,5-Trisphosphate Receptor 3) in Vascular Endothelium via KLF4 (Krüppel-Like Factor 4)-Mediated Histone Modifications. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA118312301. PMID 30917677 DOI: 10.1161/Atvbaha.118.312301  1
2018 Wang XJ, Lian TY, Jiang X, Liu SF, Li SQ, Jiang R, Wu WH, Ye J, Cheng CY, Du Y, Xu XQ, Wu Y, Peng FH, Sun K, Mao YM, ... ... Shyy JY, et al. Germline mutation causes idiopathic pulmonary arterial hypertension. The European Respiratory Journal. PMID 30578397 DOI: 10.1183/13993003.01609-2018  1
2018 Lai B, Li Z, He M, Wang Y, Chen L, Zhang J, Yang Y, Shyy JY. Atheroprone flow enhances the endothelial-to-mesenchymal transition. American Journal of Physiology. Heart and Circulatory Physiology. PMID 30052471 DOI: 10.1152/Ajpheart.00213.2018  1
2018 Bai L, Shyy JY. Shear Stress Regulation of Endothelium: A Double-edged Sword. Journal of Translational Internal Medicine. 6: 58-61. PMID 29984197 DOI: 10.2478/Jtim-2018-0019  0.56
2018 Zhang J, Dong J, Martin M, He M, Gongol B, Marin TL, Chen L, Shi X, Yin Y, Shang F, Wu Y, Huang HY, Zhang J, Zhang Y, Kang J, ... ... Shyy JY, et al. AMPK Phosphorylation of ACE2 in Endothelium Mitigates Pulmonary Hypertension. American Journal of Respiratory and Critical Care Medicine. PMID 29570986 DOI: 10.1164/Rccm.201712-2570Oc  1
2018 Gongol B, Marin T, Johnson DA, Shyy JY. Bioinformatics Approach to Identify Novel AMPK Targets. Methods in Molecular Biology (Clifton, N.J.). 1732: 99-109. PMID 29480471 DOI: 10.1007/978-1-4939-7598-3_7  1
2018 Martin M, Zhang J, Miao Y, Kang J, Huang H, He M, Dong J, Wong S, Huang H, Chen Z, Hagood JS, Shyy JY. Abstract 685: Sterol Regulatory Element-Binding Protein 2-Mediated Endothelial-to-Mesenchymal Transition Contributes to Pulmonary Fibrosis Arteriosclerosis, Thrombosis, and Vascular Biology. 38. DOI: 10.1161/Atvb.38.Suppl_1.685  1
2018 Gongol B, Marin T, Shyy J. Abstract 446: Ampk Regulates Endothelial Mirna Biogenesis Through Nucleolin Arteriosclerosis, Thrombosis, and Vascular Biology. 38. DOI: 10.1161/Atvb.38.Suppl_1.446  1
2018 He M, Huang T, Martin M, Chien S, Shyy J. Abstract 007: Athero-protective Flow Regulation of ITPR3: an Epigenetic Approach Arteriosclerosis, Thrombosis, and Vascular Biology. 38. DOI: 10.1161/Atvb.38.Suppl_1.007  1
2017 Xu MJ, Cai Y, Qu A, Shyy JY, Li W, Wang X. Immediate Early Response Gene X-1 (IEX-1) Mediates Ischemic Preconditioning-Induced Cardioprotection in Rats. Oxidative Medicine and Cellular Longevity. 2017: 6109061. PMID 29213350 DOI: 10.1155/2017/6109061  1
2017 Oh YS, Berkowitz DE, Cohen RA, Figueroa CA, Harrison DG, Humphrey JD, Larson DF, Leopold JA, Mecham RP, Ruiz-Opazo N, Santhanam L, Seta F, Shyy JYJ, Sun Z, Tsao PS, et al. A Special Report on the NHLBI Initiative to Study Cellular and Molecular Mechanisms of Arterial Stiffness and Its Association With Hypertension. Circulation Research. 121: 1216-1218. PMID 29122942 DOI: 10.1161/Circresaha.117.311703  1
2017 Zhang J, Yin Y, Chen L, Chu C, Wang Y, Lv Y, He M, Martin M, Huang PH, Mu JJ, Shyy JY, Yuan ZY. Short-term High-salt Diet Increases Corin Level to Regulate the Salt-water Balance in Humans and Rodents. American Journal of Hypertension. PMID 28985241 DOI: 10.1093/Ajh/Hpx148  1
2017 Ajami NE, Gupta S, Maurya MR, Nguyen P, Li JY, Shyy JY, Chen Z, Chien S, Subramaniam S. Systems biology analysis of longitudinal functional response of endothelial cells to shear stress. Proceedings of the National Academy of Sciences of the United States of America. PMID 28973892 DOI: 10.1073/Pnas.1707517114  1
2017 Li Z, Martin M, Zhang J, Huang HY, Bai L, Zhang J, Kang J, He M, Li J, Maurya MR, Gupta S, Zhou G, Sangwung P, Xu YJ, Lei T, ... ... Shyy JY, et al. KLF4 Regulation of Ch25h and LXR Mitigates Atherosclerosis Susceptibility. Circulation. PMID 28794002 DOI: 10.1161/Circulationaha.117.027462  1
2017 Shang F, Wang SC, Hsu CY, Miao Y, Martin M, Yin Y, Wu CC, Wang YT, Wu G, Chien S, Huang HD, Tarng DC, Shiu YT, Cheung AK, Huang PH, ... ... Shyy JY, et al. MicroRNA-92a Mediates Endothelial Dysfunction in CKD. Journal of the American Society of Nephrology : Jasn. PMID 28696247 DOI: 10.1681/ASN.2016111215  1
2017 Bai L, Li Z, Li Q, Guan H, Zhao S, Liu R, Wang R, Zhang J, Jia Y, Fan J, Wang N, Reddy JK, Shyy JY, Liu E. Mediator 1 Is Atherosclerosis Protective by Regulating Macrophage Polarization. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 28642237 DOI: 10.1161/Atvbaha.117.309672  1
2017 Huang TS, Wang KC, Quon S, Nguyen P, Chang TY, Chen Z, Li YS, Subramaniam S, Shyy JY, Chien S. LINC00341 exerts an anti-inflammatory effect on endothelial cells by repressing VCAM1. Physiological Genomics. physiolgenomics.0013. PMID 28500253 DOI: 10.1152/Physiolgenomics.00132.2016  1
2017 Chen Z, Li S, Subramaniam S, Shyy JY, Chien S. Epigenetic Regulation: A New Frontier for Biomedical Engineers. Annual Review of Biomedical Engineering. PMID 28301736 DOI: 10.1146/Annurev-Bioeng-071516-044720  1
2016 Lin TY, Wei TW, Li S, Wang SC, He M, Martin M, Zhang J, Shentu TP, Xiao H, Kang J, Wang KC, Chen Z, Chien S, Tsai MD, Shyy JY. TIFA as a crucial mediator for NLRP3 inflammasome. Proceedings of the National Academy of Sciences of the United States of America. PMID 27965388 DOI: 10.1073/Pnas.1618773114  1
2016 He M, Chen Z, Martin M, Zhang J, Sangwung P, Woo B, Tremoulet A, Shimizu C, Jain MK, Burns JC, Shyy J. miR-483 Targeting of CTGF Suppresses Endothelial-to-Mesenchymal Transition: Therapeutic Implications in Kawasaki Disease. Circulation Research. PMID 27923814 DOI: 10.1161/Circresaha.116.310233  1
2016 Shentu TP, He M, Sun X, Zhang J, Zhang F, Gongol B, Marin TL, Zhang J, Wen L, Wang Y, Geary GG, Zhu Y, Johnson DA, Shyy JY. AMP-Activated Protein Kinase and Sirtuin 1 Coregulation of Cortactin Contributes to Endothelial Function. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 27758765 DOI: 10.1161/Atvbaha.116.307871  1
2016 Shang F, Zhang J, Li Z, Zhang J, Yin Y, Wang Y, Marin TL, Gongol B, Xiao H, Zhang YY, Chen Z, Shyy JY, Lei T. Cardiovascular Protective Effect of Metformin and Telmisartan: Reduction of PARP1 Activity via the AMPK-PARP1 Cascade. Plos One. 11: e0151845. PMID 26986624 DOI: 10.1371/journal.pone.0151845  1
2016 Lin TC, Su CY, Wu PY, Lai TC, Pan WA, Jan YH, Chang YC, Yeh CT, Chen CL, Ger LP, Chang HT, Yang CJ, Huang MS, Liu YP, Lin YF, ... Shyy JY, et al. The nucleolar protein NIFK promotes cancer progression via CK1α/β-catenin in metastasis and Ki-67-dependent cell proliferation. Elife. 5. PMID 26984280 DOI: 10.7554/eLife.11288  1
2016 Lin T, Su C, Wu P, Lai T, Pan W, Jan Y, Chang Y, Yeh C, Chen C, Ger L, Chang H, Yang C, Huang M, Liu Y, Lin Y, ... Shyy JY, et al. Author response: The nucleolar protein NIFK promotes cancer progression via CK1α/β-catenin in metastasis and Ki-67-dependent cell proliferation Elife. DOI: 10.7554/Elife.11288.027  1
2015 Marin TL, Gongol B, Martin M, King SJ, Smith L, Johnson DA, Subramaniam S, Chien S, Shyy JY. Identification of AMP-activated protein kinase targets by a consensus sequence search of the proteome. Bmc Systems Biology. 9: 13. PMID 25890336 DOI: 10.1186/S12918-015-0156-0  1
2015 Chen Z, Wen L, Martin M, Hsu CY, Fang L, Lin FM, Lin TY, Geary MJ, Geary GG, Zhao Y, Johnson DA, Chen JW, Lin SJ, Chien S, Huang HD, ... ... Shyy JY, et al. Oxidative stress activates endothelial innate immunity via sterol regulatory element binding protein 2 (SREBP2) transactivation of microRNA-92a. Circulation. 131: 805-14. PMID 25550450 DOI: 10.1161/Circulationaha.114.013675  1
2014 Chen Z, Martin M, Li Z, Shyy JY. Endothelial dysfunction: the role of sterol regulatory element-binding protein-induced NOD-like receptor family pyrin domain-containing protein 3 inflammasome in atherosclerosis. Current Opinion in Lipidology. 25: 339-49. PMID 25188917 DOI: 10.1097/Mol.0000000000000107  1
2013 Wang X, Fang X, Zhou J, Chen Z, Zhao B, Xiao L, Liu A, Li YS, Shyy JY, Guan Y, Chien S, Wang N. Shear stress activation of nuclear receptor PXR in endothelial detoxification. Proceedings of the National Academy of Sciences of the United States of America. 110: 13174-9. PMID 23878263 DOI: 10.1073/pnas.1312065110  1
2013 Xiao H, Lu M, Lin TY, Chen Z, Chen G, Wang WC, Marin T, Shentu TP, Wen L, Gongol B, Sun W, Liang X, Chen J, Huang HD, Pedra JH, ... ... Shyy JY, et al. Sterol regulatory element binding protein 2 activation of NLRP3 inflammasome in endothelium mediates hemodynamic-induced atherosclerosis susceptibility. Circulation. 128: 632-42. PMID 23838163 DOI: 10.1161/Circulationaha.113.002714  1
2013 Wen L, Chen Z, Zhang F, Cui X, Sun W, Geary GG, Wang Y, Johnson DA, Zhu Y, Chien S, Shyy JY. Ca2+/calmodulin-dependent protein kinase kinase β phosphorylation of Sirtuin 1 in endothelium is atheroprotective. Proceedings of the National Academy of Sciences of the United States of America. 110: E2420-7. PMID 23754392 DOI: 10.1073/Pnas.1309354110  1
2013 Marin T, Gongol B, Chen Z, Woo B, Subramaniam S, Chien S, Shyy JY. Mechanosensitive microRNAs-role in endothelial responses to shear stress and redox state. Free Radical Biology & Medicine. 64: 61-8. PMID 23727269 DOI: 10.1016/J.Freeradbiomed.2013.05.034  1
2013 Liu Y, Tian XY, Mao G, Fang X, Fung ML, Shyy JYJ, Yu H, Wang N. Response to overexpression of 5-hydroxytryptamine 2b receptor gene in pulmonary hypertension: Still a long way to understand its transcriptional regulation Hypertension. 61: e30. PMID 23607134 DOI: 10.1161/HYPERTENSIONAHA.111.00714  1
2013 Zhou J, Li YS, Nguyen P, Wang KC, Weiss A, Kuo YC, Chiu JJ, Shyy JY, Chien S. Regulation of vascular smooth muscle cell turnover by endothelial cell-secreted microRNA-126: role of shear stress. Circulation Research. 113: 40-51. PMID 23603512 DOI: 10.1161/Circresaha.113.280883  1
2013 He M, Liang X, He L, Wen W, Zhao S, Wen L, Liu Y, Shyy JY, Yuan Z. Endothelial dysfunction in rheumatoid arthritis: the role of monocyte chemotactic protein-1-induced protein. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 1384-91. PMID 23580143 DOI: 10.1161/ATVBAHA.113.301490  1
2013 Chen Z, Shentu TP, Wen L, Johnson DA, Shyy JY. Regulation of SIRT1 by oxidative stress-responsive miRNAs and a systematic approach to identify its role in the endothelium. Antioxidants & Redox Signaling. 19: 1522-38. PMID 23477488 DOI: 10.1089/Ars.2012.4803  1
2013 Chen Z, Lai TC, Jan YH, Lin FM, Wang WC, Xiao H, Wang YT, Sun W, Cui X, Li YS, Fang T, Zhao H, Padmanabhan C, Sun R, Wang DL, ... ... Shyy JY, et al. Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis. The Journal of Clinical Investigation. 123: 1057-67. PMID 23426184 DOI: 10.1172/Jci65344  1
2013 Gongol B, Marin T, Peng IC, Woo B, Martin M, King S, Sun W, Johnson DA, Chien S, Shyy JY. AMPKα2 exerts its anti-inflammatory effects through PARP-1 and Bcl-6. Proceedings of the National Academy of Sciences of the United States of America. 110: 3161-6. PMID 23382195 DOI: 10.1073/Pnas.1222051110  1
2012 Liu Y, Tian XY, Mao G, Fang X, Fung ML, Shyy JYJ, Huang Y, Wang N. Peroxisome proliferator-activated receptor-γ ameliorates pulmonary arterial hypertension by inhibiting 5-Hydroxytryptamine 2B receptor Hypertension. 60: 1471-1478. PMID 23108648 DOI: 10.1161/HYPERTENSIONAHA.112.198887  1
2012 Chen HY, Lin YM, Chung HC, Lang YD, Lin CJ, Huang J, Wang WC, Lin FM, Chen Z, Huang HD, Shyy JY, Liang JT, Chen RH. miR-103/107 promote metastasis of colorectal cancer by targeting the metastasis suppressors DAPK and KLF4. Cancer Research. 72: 3631-41. PMID 22593189 DOI: 10.1158/0008-5472.CAN-12-0667  1
2012 Huang CC, Weng JH, Wei TY, Wu PY, Hsu PH, Chen YH, Wang SC, Qin D, Hung CC, Chen ST, Wang AH, Shyy JY, Tsai MD. Intermolecular binding between TIFA-FHA and TIFA-pT mediates tumor necrosis factor alpha stimulation and NF-κB activation. Molecular and Cellular Biology. 32: 2664-73. PMID 22566686 DOI: 10.1128/Mcb.00438-12  1
2012 Peng IC, Chen Z, Sun W, Li YS, Marin TL, Hsu PH, Su MI, Cui X, Pan S, Lytle CY, Johnson DA, Blaeser F, Chatila T, Shyy JY. Glucagon regulates ACC activity in adipocytes through the CAMKKβ/AMPK pathway. American Journal of Physiology. Endocrinology and Metabolism. 302: E1560-8. PMID 22454291 DOI: 10.1152/Ajpendo.00504.2011  1
2012 Huang CCF, Weng JH, Wei TYW, Wu PYG, Hsu PH, Chen YH, Wang SC, Qin D, Hung CC, Chen ST, Wang AHJ, Shyy JYJ, Tsai MD. Intermolecular binding between TIFA-FHA and TIFA-pt mediates tumor necrosis factor alpha stimulation and NF-κb activation Molecular and Cellular Biology. 32: 3800-3800. DOI: 10.1128/MCB.00985-12  1
2011 Wu W, Xiao H, Laguna-Fernandez A, Villarreal G, Wang KC, Geary GG, Zhang Y, Wang WC, Huang HD, Zhou J, Li YS, Chien S, Garcia-Cardena G, Shyy JY. Flow-Dependent Regulation of Kruppel-Like Factor 2 Is Mediated by MicroRNA-92a. Circulation. 124: 633-41. PMID 21768538 DOI: 10.1161/Circulationaha.110.005108  1
2011 Zhou J, Wang KC, Wu W, Subramaniam S, Shyy JY, Chiu JJ, Li JY, Chien S. MicroRNA-21 targets peroxisome proliferators-activated receptor-alpha in an autoregulatory loop to modulate flow-induced endothelial inflammation. Proceedings of the National Academy of Sciences of the United States of America. 108: 10355-60. PMID 21636785 DOI: 10.1073/Pnas.1107052108  1
2011 Fu Y, Hou Y, Fu C, Gu M, Li C, Kong W, Wang X, Shyy JY, Zhu Y. A novel mechanism of γ/δ T-lymphocyte and endothelial activation by shear stress: the role of ecto-ATP synthase β chain. Circulation Research. 108: 410-7. PMID 21193741 DOI: 10.1161/Circresaha.110.230151  1
2010 Zheng S, Li W, Xu M, Bai X, Zhou Z, Han J, Shyy JY, Wang X. Calcitonin gene-related peptide promotes angiogenesis via AMP-activated protein kinase. American Journal of Physiology. Cell Physiology. 299: C1485-92. PMID 20881236 DOI: 10.1152/ajpcell.00173.2010  1
2010 Wang P, Jiang Y, Wang Y, Shyy JY, DeFea KA. Beta-arrestin inhibits CAMKKbeta-dependent AMPK activation downstream of protease-activated-receptor-2. Bmc Biochemistry. 11: 36. PMID 20858278 DOI: 10.1186/1471-2091-11-36  1
2010 Chen Z, Peng IC, Cui X, Li YS, Chien S, Shyy JY. Shear stress, SIRT1, and vascular homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 107: 10268-73. PMID 20479254 DOI: 10.1073/Pnas.1003833107  1
2010 Fu C, He J, Li C, Shyy JY, Zhu Y. Cholesterol increases adhesion of monocytes to endothelium by moving adhesion molecules out of caveolae. Biochimica Et Biophysica Acta. 1801: 702-10. PMID 20382259 DOI: 10.1016/J.Bbalip.2010.04.001  1
2010 Wang KC, Garmire LX, Young A, Nguyen P, Trinh A, Subramaniam S, Wang N, Shyy JY, Li YS, Chien S. Role of microRNA-23b in flow-regulation of Rb phosphorylation and endothelial cell growth. Proceedings of the National Academy of Sciences of the United States of America. 107: 3234-9. PMID 20133741 DOI: 10.1073/Pnas.0914825107  1
2010 Ai D, Shyy JY, Zhu Y. Linking an insect enzyme to hypertension: angiotensin II-epoxide hydrolase interactions. Kidney International. 77: 88-92. PMID 19847158 DOI: 10.1038/ki.2009.349  1
2009 Young A, Wu W, Sun W, Benjamin Larman H, Larman HB, Wang N, Li YS, Shyy JY, Chien S, García-Cardeña G. Flow activation of AMP-activated protein kinase in vascular endothelium leads to Krüppel-like factor 2 expression. Arteriosclerosis, Thrombosis, and Vascular Biology. 29: 1902-8. PMID 19696400 DOI: 10.1161/Atvbaha.109.193540  1
2009 Guo D, Hildebrandt IJ, Prins RM, Soto H, Mazzotta MM, Dang J, Czernin J, Shyy JY, Watson AD, Phelps M, Radu CG, Cloughesy TF, Mischel PS. The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis. Proceedings of the National Academy of Sciences of the United States of America. 106: 12932-7. PMID 19625624 DOI: 10.1073/Pnas.0906606106  1
2009 Yuan H, Shyy JY, Martins-Green M. Second-hand smoke stimulates lipid accumulation in the liver by modulating AMPK and SREBP-1. Journal of Hepatology. 51: 535-47. PMID 19556020 DOI: 10.1016/J.Jhep.2009.03.026  1
2009 Xie X, Liao H, Dang H, Pang W, Guan Y, Wang X, Shyy JY, Zhu Y, Sladek FM. Down-regulation of hepatic HNF4alpha gene expression during hyperinsulinemia via SREBPs. Molecular Endocrinology (Baltimore, Md.). 23: 434-43. PMID 19179483 DOI: 10.1210/Me.2007-0531  1
2009 Chen Z, Peng IC, Sun W, Su MI, Hsu PH, Fu Y, Zhu Y, DeFea K, Pan S, Tsai MD, Shyy JY. AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633. Circulation Research. 104: 496-505. PMID 19131647 DOI: 10.1161/Circresaha.108.187567  1
2009 Ai D, Pang W, Li N, Xu M, Jones PD, Yang J, Zhang Y, Chiamvimonvat N, Shyy JY, Hammock BD, Zhu Y. Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy. Proceedings of the National Academy of Sciences of the United States of America. 106: 564-9. PMID 19126686 DOI: 10.1073/Pnas.0811022106  1
2009 Dang H, Liu Y, Pang W, Li C, Wang N, Shyy JY, Zhu Y. Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile. The Journal of Biological Chemistry. 284: 6218-26. PMID 19119143 DOI: 10.1074/jbc.M803702200  1
2008 Wang Y, Shyy JY, Chien S. Fluorescence proteins, live-cell imaging, and mechanobiology: seeing is believing. Annual Review of Biomedical Engineering. 10: 1-38. PMID 18647110 DOI: 10.1146/Annurev.Bioeng.010308.161731  1
2008 Li X, Han Y, Pang W, Li C, Xie X, Shyy JY, Zhu Y. AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 1789-95. PMID 18599796 DOI: 10.1161/ATVBAHA.108.172452  1
2008 Ouyang M, Lu S, Li XY, Xu J, Seong J, Giepmans BN, Shyy JY, Weiss SJ, Wang Y. Visualization of polarized membrane type 1 matrix metalloproteinase activity in live cells by fluorescence resonance energy transfer imaging. The Journal of Biological Chemistry. 283: 17740-8. PMID 18441011 DOI: 10.1074/Jbc.M709872200  1
2008 Yao M, Zhou R, Petreaca M, Shyy J, Martins‐Green M. 056 Activation of Sterol Regulatory Element‐Binding Proteins ((SREBPs) is Critical in IL‐8‐Induced Angigiogenesi Wound Repair and Regeneration. 13. DOI: 10.1111/J.1067-1927.2005.130215Bd.X  1
2008 Benallaoua M, Thelier N, Lydia T, Shyy J, Poiraudeau S, Savouret J, Corvol M, Chauvet C, Rannou F. 455 Cyclic Tensile Stretch Induces Prostaglandin-E2 Production In Intervertebral Disc Cells Through An Nfkappab Pathway Differing From Ii-1B Osteoarthritis and Cartilage. 16. DOI: 10.1016/S1063-4584(08)60496-3  1
2007 Zhu M, Fu Y, Hou Y, Wang N, Guan Y, Tang C, Shyy JY, Zhu Y. Laminar shear stress regulates liver X receptor in vascular endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 527-33. PMID 18096827 DOI: 10.1161/ATVBAHA.107.143487  0.32
2007 Ai D, Fu Y, Guo D, Tanaka H, Wang N, Tang C, Hammock BD, Shyy JY, Zhu Y. Angiotensin II up-regulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America. 104: 9018-23. PMID 17495027 DOI: 10.1073/Pnas.0703229104  1
2007 Tellier N, Benallaoua M, François M, Batteux F, Shyy J, Fitting C, Tsagris L, Boczkowski J, Savouret J-, Corvol M-, Poiraudeau S, Rannou F. L'induction pharmacologique de l'hème oxygenase-1 diminue la phase aigüe de l'arthrite Revue Du Rhumatisme. 74: 1154. DOI: 10.1016/J.Rhum.2007.10.297  1
2006 Sun W, Lee TS, Zhu M, Gu C, Wang Y, Zhu Y, Shyy JY. Statins activate AMP-activated protein kinase in vitro and in vivo. Circulation. 114: 2655-62. PMID 17116771 DOI: 10.1161/Circulationaha.106.630194  1
2006 Yao M, Zhou RH, Petreaca M, Zheng L, Shyy J, Martins-Green M. Activation of sterol regulatory element-binding proteins (SREBPs) is critical in IL-8-induced angiogenesis. Journal of Leukocyte Biology. 80: 608-20. PMID 16849610 DOI: 10.1189/Jlb.0304175  1
2006 Zhang Y, Lee TS, Kolb EM, Sun K, Lu X, Sladek FM, Kassab GS, Garland T, Shyy JY. AMP-activated protein kinase is involved in endothelial NO synthase activation in response to shear stress. Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 1281-7. PMID 16601232 DOI: 10.1161/01.Atv.0000221230.08596.98  1
2005 Liu Y, Zhang Y, Schmelzer K, Lee TS, Fang X, Zhu Y, Spector AA, Gill S, Morisseau C, Hammock BD, Shyy JY. The antiinflammatory effect of laminar flow: the role of PPARgamma, epoxyeicosatrienoic acids, and soluble epoxide hydrolase. Proceedings of the National Academy of Sciences of the United States of America. 102: 16747-52. PMID 16267130 DOI: 10.1073/Pnas.0508081102  1
2005 Zhu Y, Liao H, Xie X, Yuan Y, Lee TS, Wang N, Wang X, Shyy JY, Stemerman MB. Oxidized LDL downregulates ATP-binding cassette transporter-1 in human vascular endothelial cells via inhibiting liver X receptor (LXR). Cardiovascular Research. 68: 425-32. PMID 16099444 DOI: 10.1016/J.Cardiores.2005.07.003  1
2005 Fang X, Hu S, Watanabe T, Weintraub NL, Snyder GD, Yao J, Liu Y, Shyy JY, Hammock BD, Spector AA. Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors. The Journal of Pharmacology and Experimental Therapeutics. 314: 260-70. PMID 15798002 DOI: 10.1124/Jpet.105.085605  1
2004 Yeh M, Cole AL, Choi J, Liu Y, Tulchinsky D, Qiao JH, Fishbein MC, Dooley AN, Hovnanian T, Mouilleseaux K, Vora DK, Yang WP, Gargalovic P, Kirchgessner T, Shyy JY, et al. Role for sterol regulatory element-binding protein in activation of endothelial cells by phospholipid oxidation products. Circulation Research. 95: 780-8. PMID 15388640 DOI: 10.1161/01.Res.0000146030.53089.18  1
2004 Zeng L, Liao H, Liu Y, Lee TS, Zhu M, Wang X, Stemerman MB, Zhu Y, Shyy JY. Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism. The Journal of Biological Chemistry. 279: 48801-7. PMID 15358760 DOI: 10.1074/Jbc.M407817200  1
2004 Liu Y, Zhu Y, Rannou F, Lee TS, Formentin K, Zeng L, Yuan X, Wang N, Chien S, Forman BM, Shyy JY. Laminar flow activates peroxisome proliferator-activated receptor-gamma in vascular endothelial cells. Circulation. 110: 1128-33. PMID 15313948 DOI: 10.1161/01.CIR.0000139850.08365.EC  1
2004 Zhou RH, Yao M, Lee TS, Zhu Y, Martins-Green M, Shyy JY. Vascular endothelial growth factor activation of sterol regulatory element binding protein: a potential role in angiogenesis. Circulation Research. 95: 471-8. PMID 15271857 DOI: 10.1161/01.Res.0000139956.42923.4A  1
2004 Rannou F, Lee TS, Zhou RH, Chin J, Lotz JC, Mayoux-Benhamou MA, Barbet JP, Chevrot A, Shyy JY. Intervertebral disc degeneration: the role of the mitochondrial pathway in annulus fibrosus cell apoptosis induced by overload. The American Journal of Pathology. 164: 915-24. PMID 14982845 DOI: 10.1016/S0002-9440(10)63179-3  1
2004 Zeng L, Lu M, Mori K, Luo S, Lee AS, Zhu Y, Shyy JY. ATF6 modulates SREBP2-mediated lipogenesis. The Embo Journal. 23: 950-8. PMID 14765107 DOI: 10.1038/Sj.Emboj.7600106  1
2004 Wang Y, Chang J, Li YC, Li YS, Shyy JY, Chien S. Shear stress and VEGF activate IKK via the Flk-1/Cbl/Akt signaling pathway. American Journal of Physiology. Heart and Circulatory Physiology. 286: H685-92. PMID 14551058 DOI: 10.1152/Ajpheart.00237.2003  1
2003 Lin T, Zeng L, Liu Y, DeFea K, Schwartz MA, Chien S, Shyy JY. Rho-ROCK-LIMK-cofilin pathway regulates shear stress activation of sterol regulatory element binding proteins. Circulation Research. 92: 1296-304. PMID 12775580 DOI: 10.1161/01.Res.0000078780.65824.8B  1
2003 Zeng L, Zhang Y, Chien S, Liu X, Shyy JY. The role of p53 deacetylation in p21Waf1 regulation by laminar flow. The Journal of Biological Chemistry. 278: 24594-9. PMID 12716906 DOI: 10.1074/Jbc.M301955200  1
2002 Shyy JYJ, Chien S. Role of integrins in endothelial mechanosensing of shear stress Circulation Research. 91: 769-775. PMID 12411390 DOI: 10.1161/01.RES.0000038487.19924.18  1
2002 Wang Y, Miao H, Li S, Chen KD, Li YS, Yuan S, Shyy JY, Chien S. Interplay between integrins and FLK-1 in shear stress-induced signaling. American Journal of Physiology. Cell Physiology. 283: C1540-7. PMID 12372815 DOI: 10.1152/Ajpcell.00222.2002  1
2002 Sotoudeh M, Li YS, Yajima N, Chang CC, Tsou TC, Wang Y, Usami S, Ratcliffe A, Chien S, Shyy JY. Induction of apoptosis in vascular smooth muscle cells by mechanical stretch. American Journal of Physiology. Heart and Circulatory Physiology. 282: H1709-16. PMID 11959635 DOI: 10.1152/ajpheart.00744.2001  0.32
2002 Liu Y, Chen BP, Lu M, Zhu Y, Stemerman MB, Chien S, Shyy JY. Shear stress activation of SREBP1 in endothelial cells is mediated by integrins. Arteriosclerosis, Thrombosis, and Vascular Biology. 22: 76-81. PMID 11788464 DOI: 10.1161/Hq0102.101822  1
2001 Chen BP, Li YS, Zhao Y, Chen KD, Li S, Lao J, Yuan S, Shyy JY, Chien S. DNA microarray analysis of gene expression in endothelial cells in response to 24-h shear stress. Physiological Genomics. 7: 55-63. PMID 11595792 DOI: 10.1152/Physiolgenomics.2001.7.1.55  1
2000 Li KW, Falcovitz YH, Nagrampa JP, Chen AC, Lottman LM, Shyy JY, Sah RL. Mechanical compression modulates proliferation of transplanted chondrocytes. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 18: 374-82. PMID 10937623 DOI: 10.1002/Jor.1100180308  1
1999 Kaunas R, Shyy JY, Chien S. Oscillatory equi-biaxial strain activates JNK in a frequency-dependent manner in bovine aortic endothelial cells Annual International Conference of the Ieee Engineering in Medicine and Biology - Proceedings. 1: 5.  1
1998 Sotoudeh M, Jalali S, Usami S, Shyy JY, Chien S. A strain device imposing dynamic and uniform equi-biaxial strain to cultured cells. Annals of Biomedical Engineering. 26: 181-189. PMID 9525759 DOI: 10.1114/1.88  1
1998 Chien S, Li S, Shyy JY. Effects of Mechanical Forces on Signal Transduction and Gene Expression in Endothelial Cells Hypertension. 31: 162-169. PMID 9453297 DOI: 10.1161/01.Hyp.31.1.162  1
1998 Sotoudeh M, Jalali S, Usami S, Shyy JY, Chen S. Erratum: “A Strain Device Imposing Dynamic and Uniform Equi-Biaxial Strain to Cultured Cells” [Ann. Biomed. Eng. 26, 181–189 (1998) Annals of Biomedical Engineering. 26: 735-735. DOI: 10.1114/1.48  1
1997 Chiu JJ, Wung BS, Shyy JY, Hsieh HJ, Wang DL. Reactive oxygen species are involved in shear stress-induced intercellular adhesion molecule-1 expression in endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 17: 3570-7. PMID 9437207 DOI: 10.1161/01.ATV.17.12.3570  1
1997 Tsao PS, Wang BY, Buitrago R, Shyy JYJ, Cooke JP. Nitric oxide regulates monocyte chemotactic protein-1 Circulation. 96: 934-940. PMID 9264504 DOI: 10.1161/01.CIR.96.3.934  1
1996 Li YS, Shyy JY, Li S, Lee J, Su B, Karin M, Chien S. The Ras-JNK pathway is involved in shear-induced gene expression. Molecular and Cellular Biology. 16: 5947-54. PMID 8887624 DOI: 10.1128/Mcb.16.11.5947  1
1996 Shyy JY, Li YS, Lin MC, Chen W, Yuan S, Usami S, Chien S. Multiple cis-elements mediate shear stress-induced gene expression. Journal of Biomechanics. 28: 1451-7. PMID 8666585 DOI: 10.1016/0021-9290(95)00093-3  0.4
1995 Shyy JY, Lin MC, Han J, Lu Y, Petrime M, Chien S. The cis-acting phorbol ester "12-O-tetradecanoylphorbol 13-acetate"-responsive element is involved in shear stress-induced monocyte chemotactic protein 1 gene expression. Proceedings of the National Academy of Sciences of the United States of America. 92: 8069-73. PMID 7644539 DOI: 10.1073/pnas.92.17.8069  0.52
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