Coleen T. Murphy - Publications

Molecular Biology Princeton University, Princeton, NJ 
Molecular mechanisms of aging, C. Elegans

76 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Stevenson ME, Bieri G, Kaletsky R, St Ange J, Remesal L, Pratt KJB, Zhou S, Weng Y, Murphy CT, Villeda SA. Neuronal activation of G EGL-30/GNAQ late in life rejuvenates cognition across species. Cell Reports. 42: 113151. PMID 37713310 DOI: 10.1016/j.celrep.2023.113151  0.731
2023 Sengupta T, Ange JS, Moore R, Kaletsky R, Marogi J, Myhrvold C, Gitai Z, Murphy CT. A small RNA from a natural bacterial pathogen of induces transgenerational inheritance of learned avoidance. Biorxiv : the Preprint Server For Biology. PMID 37503135 DOI: 10.1101/2023.07.20.549962  0.667
2023 Sengupta T, Kaletsky R, Murphy CT. The Logic of Transgenerational Inheritance: Timescales of Adaptation. Annual Review of Cell and Developmental Biology. PMID 37339681 DOI: 10.1146/annurev-cellbio-020923-114620  0.686
2022 Cota V, Sohrabi S, Kaletsky R, Murphy CT. Oocyte mitophagy is critical for extended reproductive longevity. Plos Genetics. 18: e1010400. PMID 36126046 DOI: 10.1371/journal.pgen.1010400  0.708
2022 McIntyre LM, Huertas F, Morse AM, Kaletsky R, Murphy CT, Kalia V, Miller GW, Moskalenko O, Conesa A, Mor DE. GAIT-GM integrative cross-omics analyses reveal cholinergic defects in a C. elegans model of Parkinson's disease. Scientific Reports. 12: 3268. PMID 35228596 DOI: 10.1038/s41598-022-07238-9  0.771
2022 Rahimi M, Sohrabi S, Murphy CT. Novel elasticity measurements reveal C. elegans cuticle stiffens with age and in a long-lived mutant. Biophysical Journal. 121: 515-524. PMID 35065051 DOI: 10.1016/j.bpj.2022.01.013  0.556
2021 Moore RS, Kaletsky R, Lesnik C, Cota V, Blackman E, Parsons LR, Gitai Z, Murphy CT. The role of the Cer1 transposon in horizontal transfer of transgenerational memory. Cell. PMID 34363756 DOI: 10.1016/j.cell.2021.07.022  0.701
2021 Moore RS, Kaletsky R, Murphy CT. Protocol for transgenerational learned pathogen avoidance behavior assays in . Star Protocols. 2: 100384. PMID 33748786 DOI: 10.1016/j.xpro.2021.100384  0.684
2021 Sohrabi S, Mor DE, Kaletsky R, Keyes W, Murphy CT. High-throughput behavioral screen in C. elegans reveals Parkinson's disease drug candidates. Communications Biology. 4: 203. PMID 33589689 DOI: 10.1038/s42003-021-01731-z  0.767
2021 Baumeister R, Murphy CT, Heimbucher T. Metabolic adaptation to hypoxia: do worms and cancer cells share common metabolic responses to hypoxic stress? Cell Death and Differentiation. PMID 33580155 DOI: 10.1038/s41418-021-00741-y  0.708
2020 Heimbucher T, Hog J, Gupta P, Murphy CT. Author Correction: PQM-1 controls hypoxic survival via regulation of lipid metabolism. Nature Communications. 11: 6018. PMID 33219230 DOI: 10.1038/s41467-020-19868-6  0.715
2020 Mor DE, Murphy CT. Mitochondrial hyperactivity as a potential therapeutic target in Parkinson's disease. Translational Medicine of Aging. 4: 117-120. PMID 33178902 DOI: 10.1016/J.Tma.2020.07.007  0.768
2020 Mor DE, Sohrabi S, Kaletsky R, Keyes W, Tartici A, Kalia V, Miller GW, Murphy CT. Metformin rescues Parkinson's disease phenotypes caused by hyperactive mitochondria. Proceedings of the National Academy of Sciences of the United States of America. PMID 33024014 DOI: 10.1073/pnas.2009838117  0.772
2020 Heimbucher T, Hog J, Gupta P, Murphy CT. PQM-1 controls hypoxic survival via regulation of lipid metabolism. Nature Communications. 11: 4627. PMID 33009389 DOI: 10.1038/s41467-020-18369-w  0.736
2020 Kaletsky R, Moore RS, Vrla GD, Parsons LR, Gitai Z, Murphy CT. C. elegans interprets bacterial non-coding RNAs to learn pathogenic avoidance. Nature. PMID 32908307 DOI: 10.1038/S41586-020-2699-5  0.681
2020 Templeman NM, Cota V, Keyes W, Kaletsky R, Murphy CT. CREB Non-autonomously Controls Reproductive Aging through Hedgehog/Patched Signaling. Developmental Cell. PMID 32544391 DOI: 10.1016/J.Devcel.2020.05.023  0.793
2020 Kaletsky R, Murphy CT. Transcriptional Profiling of C. elegans Adult Cells and Tissues with Age. Methods in Molecular Biology (Clifton, N.J.). 2144: 177-186. PMID 32410035 DOI: 10.1007/978-1-0716-0592-9_16  0.741
2019 Kaletsky R, Murphy CT. Publisher Correction: Gut feelings: microRNAs tune protein quality control and ageing to odours. Nature Metabolism. 1: 416. PMID 32694726 DOI: 10.1038/s42255-019-0050-y  0.65
2019 Kaletsky R, Murphy CT. Gut feelings: microRNAs tune protein quality control and ageing to odours. Nature Metabolism. 1: 306-307. PMID 32694717 DOI: 10.1038/s42255-019-0042-y  0.685
2019 Arey RN, Kaletsky R, Murphy CT. Nervous system-wide profiling of presynaptic mRNAs reveals regulators of associative memory. Scientific Reports. 9: 20314. PMID 31889133 DOI: 10.1038/S41598-019-56908-8  0.768
2019 Shi C, Booth LN, Murphy CT. Insulin-like peptides and the mTOR-TFEB pathway protect hermaphrodites from Mating-induced Death. Elife. 8. PMID 31282862 DOI: 10.7554/Elife.46413  0.305
2019 Moore RS, Kaletsky R, Murphy CT. Piwi/PRG-1 Argonaute and TGF-β Mediate Transgenerational Learned Pathogenic Avoidance. Cell. PMID 31178117 DOI: 10.1016/J.Cell.2019.05.024  0.69
2019 Heimbucher T, Murphy CT. A PBX/MEIS Complex Balances Reproduction and Somatic Resilience. Developmental Cell. 49: 157-158. PMID 31014476 DOI: 10.1016/J.Devcel.2019.04.005  0.756
2019 Heimbucher T, Murphy CT. Investigating Mechanisms that Control Ubiquitin-Mediated DAF-16/FOXO Protein Turnover. Methods in Molecular Biology (Clifton, N.J.). 1890: 41-49. PMID 30414143 DOI: 10.1007/978-1-4939-8900-3_4  0.742
2019 Kaletsky R, Murphy CT. Publisher Correction: Gut feelings: microRNAs tune protein quality control and ageing to odours Nature Metabolism. 1: 416-416. DOI: 10.1038/s42255-019-0050-y  0.685
2019 Kaletsky R, Murphy CT. Gut feelings: microRNAs tune protein quality control and ageing to odours Nature Metabolism. 1: 306-307. DOI: 10.1038/S42255-019-0042-Y  0.685
2018 Yao V, Kaletsky R, Keyes W, Mor DE, Wong AK, Sohrabi S, Murphy CT, Troyanskaya OG. An integrative tissue-network approach to identify and test human disease genes. Nature Biotechnology. PMID 30346941 DOI: 10.1038/Nbt.4246  0.775
2018 Tabuchi TM, Rechtsteiner A, Jeffers TE, Egelhofer TA, Murphy CT, Strome S. Caenorhabditis elegans sperm carry a histone-based epigenetic memory of both spermatogenesis and oogenesis. Nature Communications. 9: 4310. PMID 30333496 DOI: 10.1038/S41467-018-06236-8  0.316
2018 Kaletsky R, Yao V, Williams A, Runnels AM, Tadych A, Zhou S, Troyanskaya OG, Murphy CT. Transcriptome analysis of adult Caenorhabditis elegans cells reveals tissue-specific gene and isoform expression. Plos Genetics. 14: e1007559. PMID 30096138 DOI: 10.1371/Journal.Pgen.1007559  0.718
2018 Arey RN, Stein GM, Kaletsky R, Kauffman A, Murphy CT. Activation of G Signaling Enhances Memory Consolidation and Slows Cognitive Decline. Neuron. PMID 29656871 DOI: 10.1016/J.Neuron.2018.03.039  0.776
2018 Templeman NM, Luo S, Kaletsky R, Shi C, Ashraf J, Keyes W, Murphy CT. Insulin Signaling Regulates Oocyte Quality Maintenance with Age via Cathepsin B Activity. Current Biology : Cb. PMID 29478855 DOI: 10.1016/J.Cub.2018.01.052  0.799
2018 Mack HI, Heimbucher T, Murphy CT. The nematode Caenorhabditis elegans as a model for aging research Drug Discovery Today: Disease Models. 27: 3-13. DOI: 10.1016/J.Ddmod.2018.11.001  0.768
2017 Templeman NM, Murphy CT. Regulation of reproduction and longevity by nutrient-sensing pathways. The Journal of Cell Biology. PMID 29074705 DOI: 10.1083/Jcb.201707168  0.772
2017 Son HG, Seo M, Ham S, Hwang W, Lee D, An SW, Artan M, Seo K, Kaletsky R, Arey RN, Ryu Y, Ha CM, Kim YK, Murphy CT, Roh TY, et al. RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans. Nature Communications. 8: 14749. PMID 28276441 DOI: 10.1038/Ncomms14749  0.781
2016 Arey RN, Murphy CT. Conserved regulators of cognitive aging: From Worms to Humans. Behavioural Brain Research. PMID 27329151 DOI: 10.1016/J.Bbr.2016.06.035  0.776
2016 Crocker A, Guan XJ, Murphy CT, Murthy M. Cell-Type-Specific Transcriptome Analysis in the Drosophila Mushroom Body Reveals Memory-Related Changes in Gene Expression. Cell Reports. PMID 27160913 DOI: 10.1016/J.Celrep.2016.04.046  0.363
2016 Li LB, Lei H, Arey RN, Li P, Liu J, Murphy CT, Xu XZ, Shen K. The Neuronal Kinesin UNC-104/KIF1A Is a Key Regulator of Synaptic Aging and Insulin Signaling-Regulated Memory. Current Biology : Cb. PMID 26877087 DOI: 10.1016/J.Cub.2015.12.068  0.812
2015 Wang J, Kaletsky R, Silva M, Williams A, Haas LA, Androwski RJ, Landis JN, Patrick C, Rashid A, Santiago-Martinez D, Gravato-Nobre M, Hodgkin J, Hall DH, Murphy CT, Barr MM. Cell-Specific Transcriptional Profiling of Ciliated Sensory Neurons Reveals Regulators of Behavior and Extracellular Vesicle Biogenesis. Current Biology : Cb. PMID 26687621 DOI: 10.1016/J.Cub.2015.10.057  0.72
2015 Kaletsky R, Lakhina V, Arey R, Williams A, Landis J, Ashraf J, Murphy CT. The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators. Nature. PMID 26675724 DOI: 10.1038/Nature16483  0.773
2015 DiLoreto R, Murphy CT. The cell biology of aging. Molecular Biology of the Cell. 26: 4524-31. PMID 26668170 DOI: 10.1091/Mbc.E14-06-1084  0.399
2015 Lakhina V, Murphy CT. Genome Sequencing Fishes out Longevity Genes. Cell. 163: 1312-3. PMID 26638067 DOI: 10.1016/J.Cell.2015.11.040  0.784
2015 Hahm JH, Kim S, DiLoreto R, Shi C, Lee SV, Murphy CT, Nam HG. C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation. Nature Communications. 6: 8919. PMID 26586186 DOI: 10.1038/Ncomms9919  0.337
2015 Lakhina V, Murphy CT. For longevity, perception is everything. Cell. 160: 807-9. PMID 25723157 DOI: 10.1016/J.Cell.2015.02.027  0.788
2015 Lakhina V, Arey RN, Kaletsky R, Kauffman A, Stein G, Keyes W, Xu D, Murphy CT. Genome-wide functional analysis of CREB/long-term memory-dependent transcription reveals distinct basal and memory gene expression programs. Neuron. 85: 330-45. PMID 25611510 DOI: 10.1016/J.Neuron.2014.12.029  0.752
2015 Ewald CY, Landis JN, Porter Abate J, Murphy CT, Blackwell TK. Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity. Nature. 519: 97-101. PMID 25517099 DOI: 10.1038/Nature14021  0.388
2015 Li S, Stone HA, Murphy CT. A microfluidic device and automatic counting system for the study of C. elegans reproductive aging. Lab On a Chip. 15: 524-31. PMID 25407755 DOI: 10.1039/C4Lc01028K  0.326
2014 Stein GM, Murphy CT. C. elegans positive olfactory associative memory is a molecularly conserved behavioral paradigm. Neurobiology of Learning and Memory. 115: 86-94. PMID 25108196 DOI: 10.1016/J.Nlm.2014.07.011  0.354
2014 Fernandes de Abreu DA, Caballero A, Fardel P, Stroustrup N, Chen Z, Lee K, Keyes WD, Nash ZM, López-Moyado IF, Vaggi F, Cornils A, Regenass M, Neagu A, Ostojic I, Liu C, ... ... Murphy CT, et al. An insulin-to-insulin regulatory network orchestrates phenotypic specificity in development and physiology. Plos Genetics. 10: e1004225. PMID 24675767 DOI: 10.1371/Journal.Pgen.1004225  0.746
2013 Murphy CT, Hu PJ. Insulin/insulin-like growth factor signaling in C. elegans. Wormbook : the Online Review of C. Elegans Biology. 1-43. PMID 24395814 DOI: 10.1895/Wormbook.1.164.1  0.365
2013 Tepper RG, Ashraf J, Kaletsky R, Kleemann G, Murphy CT, Bussemaker HJ. PQM-1 complements DAF-16 as a key transcriptional regulator of DAF-2-mediated development and longevity. Cell. 154: 676-90. PMID 23911329 DOI: 10.1016/J.Cell.2013.07.006  0.779
2012 Stein GM, Murphy CT. The Intersection of Aging, Longevity Pathways, and Learning and Memory in C. elegans. Frontiers in Genetics. 3: 259. PMID 23226155 DOI: 10.3389/Fgene.2012.00259  0.412
2012 Blackstone C, Murphy CT. Cell biology of disease and aging: A two-way street Molecular Biology of the Cell. 23: 975. DOI: 10.1091/Mbc.E11-12-0985  0.376
2011 Rizki G, Iwata TN, Li J, Riedel CG, Picard CL, Jan M, Murphy CT, Lee SS. The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO. Plos Genetics. 7: e1002235. PMID 21909281 DOI: 10.1371/Journal.Pgen.1002235  0.378
2011 Liu G, Rogers J, Murphy CT, Rongo C. EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan. The Embo Journal. 30: 2990-3003. PMID 21673654 DOI: 10.1038/Emboj.2011.195  0.334
2011 Kauffman A, Parsons L, Stein G, Wills A, Kaletsky R, Murphy C. C. elegans positive butanone learning, short-term, and long-term associative memory assays. Journal of Visualized Experiments : Jove. PMID 21445035 DOI: 10.3791/2490  0.771
2011 Luo S, Murphy CT. Caenorhabditis elegans reproductive aging: Regulation and underlying mechanisms. Genesis (New York, N.Y. : 2000). 49: 53-65. PMID 21105070 DOI: 10.1002/Dvg.20694  0.622
2010 Luo S, Kleemann GA, Ashraf JM, Shaw WM, Murphy CT. TGF-β and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance. Cell. 143: 299-312. PMID 20946987 DOI: 10.1016/J.Cell.2010.09.013  0.791
2010 Kauffman AL, Ashraf JM, Corces-Zimmerman MR, Landis JN, Murphy CT. Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age. Plos Biology. 8: e1000372. PMID 20502519 DOI: 10.1371/Journal.Pbio.1000372  0.791
2010 Kaletsky R, Murphy CT. The role of insulin/IGF-like signaling in C. elegans longevity and aging. Disease Models & Mechanisms. 3: 415-9. PMID 20354111 DOI: 10.1242/Dmm.001040  0.741
2010 Landis JN, Murphy CT. Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 239: 1405-12. PMID 20140911 DOI: 10.1002/Dvdy.22244  0.356
2009 Luo S, Shaw WM, Ashraf J, Murphy CT. TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging. Plos Genetics. 5: e1000789. PMID 20041217 DOI: 10.1371/Journal.Pgen.1000789  0.613
2009 Lee SJ, Murphy CT, Kenyon C. Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression. Cell Metabolism. 10: 379-91. PMID 19883616 DOI: 10.1016/J.Cmet.2009.10.003  0.505
2009 Oliveira RP, Porter Abate J, Dilks K, Landis J, Ashraf J, Murphy CT, Blackwell TK. Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf. Aging Cell. 8: 524-41. PMID 19575768 DOI: 10.1111/J.1474-9726.2009.00501.X  0.328
2009 Kleemann GA, Murphy CT. The endocrine regulation of aging in Caenorhabditis elegans. Molecular and Cellular Endocrinology. 299: 51-7. PMID 19059305 DOI: 10.1016/J.Mce.2008.10.048  0.792
2007 Murphy CT, Lee SJ, Kenyon C. Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 104: 19046-50. PMID 18025456 DOI: 10.1073/Pnas.0709613104  0.518
2007 Shaw WM, Luo S, Landis J, Ashraf J, Murphy CT. The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling. Current Biology : Cb. 17: 1635-45. PMID 17900898 DOI: 10.1016/J.Cub.2007.08.058  0.585
2006 Murphy CT. The search for DAF-16/FOXO transcriptional targets: approaches and discoveries. Experimental Gerontology. 41: 910-21. PMID 16934425 DOI: 10.1016/J.Exger.2006.06.040  0.374
2006 Kenyon C, Murphy CT. Enrichment of regulatory motifs upstream of predicted DAF-16 targets. Nature Genetics. 38: 397-8; author reply . PMID 16570056 DOI: 10.1038/Ng0406-397  0.452
2006 Murphy CT. Using whole-genome transcriptional analyses to identify molecular mechanisms of aging Drug Discovery Today: Disease Mechanisms. 3: 41-46. DOI: 10.1016/J.Ddmec.2006.02.012  0.385
2004 McCarroll SA, Murphy CT, Zou S, Pletcher SD, Chin CS, Jan YN, Kenyon C, Bargmann CI, Li H. Comparing genomic expression patterns across species identifies shared transcriptional profile in aging. Nature Genetics. 36: 197-204. PMID 14730301 DOI: 10.1038/Ng1291  0.518
2003 Murphy CT, McCarroll SA, Bargmann CI, Fraser A, Kamath RS, Ahringer J, Li H, Kenyon C. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature. 424: 277-83. PMID 12845331 DOI: 10.1038/Nature01789  0.548
2003 Hsu AL, Murphy CT, Kenyon C. Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science (New York, N.Y.). 300: 1142-5. PMID 12750521 DOI: 10.1126/Science.1083701  0.689
2001 Murphy CT, Rock RS, Spudich JA. A myosin II mutation uncouples ATPase activity from motility and shortens step size. Nature Cell Biology. 3: 311-5. PMID 11231583 DOI: 10.1038/35060110  0.692
2000 Murphy CT, Spudich JA. Variable surface loops and myosin activity: accessories to a motor. Journal of Muscle Research and Cell Motility. 21: 139-51. PMID 10961838 DOI: 10.1023/A:1005610007209  0.479
1999 Murphy CT, Spudich JA. The sequence of the myosin 50-20K loop affects Myosin's affinity for actin throughout the actin-myosin ATPase cycle and its maximum ATPase activity. Biochemistry. 38: 3785-92. PMID 10090768 DOI: 10.1021/Bi9826815  0.48
1998 Murphy CT, Spudich JA. Dictyostelium myosin 25-50K loop substitutions specifically affect ADP release rates. Biochemistry. 37: 6738-44. PMID 9578557 DOI: 10.1021/Bi972903J  0.481
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