Robert P. Hausinger - Publications

Biochemistry and Molecular Biology Michigan State University, East Lansing, MI 

167 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Herr CQ, Macomber L, Kalliri E, Hausinger RP. Glutarate L-2-hydroxylase (CsiD/GlaH) is an archetype Fe(II)/2-oxoglutarate-dependent dioxygenase. Advances in Protein Chemistry and Structural Biology. 117: 63-90. PMID 31564307 DOI: 10.1016/bs.apcsb.2019.05.001  0.52
2019 John CW, Hausinger RP, Proshlyakov DA. Structural origin of the large redox-linked reorganization in the 2-oxoglutarate dependent oxygenase, TauD. Journal of the American Chemical Society. PMID 31475523 DOI: 10.1021/jacs.9b07493  0.56
2019 John CW, Swain GM, Hausinger RP, Proshlyakov DA. Strongly Coupled Redox-Linked Conformational Switching at the Active Site of the Non-Heme Iron-Dependent Dioxygenase, TauD. The Journal of Physical Chemistry. B. PMID 31433947 DOI: 10.1021/acs.jpcb.9b05866  0.56
2018 Herr CQ, Hausinger RP. Amazing Diversity in Biochemical Roles of Fe(II)/2-Oxoglutarate Oxygenases. Trends in Biochemical Sciences. PMID 29709390 DOI: 10.1016/j.tibs.2018.04.002  0.44
2018 Eschweiler JD, Farrugia MA, Dixit SM, Hausinger RP, Ruotolo BT. A Structural Model of the Urease Activation Complex Derived from Ion Mobility-Mass Spectrometry and Integrative Modeling. Structure (London, England : 1993). PMID 29576318 DOI: 10.1016/j.str.2018.03.001  0.92
2017 Müller TA, Struble SL, Meek K, Hausinger RP. Characterization of human AlkB homolog 1 produced in mammalian cells and demonstration of mitochondrial dysfunction in ALKBH1-deficient cells. Biochemical and Biophysical Research Communications. PMID 29097205 DOI: 10.1016/j.bbrc.2017.10.158  0.4
2017 Martinez S, Fellner M, Herr CQ, Ritchie A, Hu J, Hausinger RP. Structures and Mechanisms of the Non-Heme Fe(II)- and 2-Oxoglutarate-Dependent Ethylene-Forming Enzyme: Substrate Binding Creates a Twist. Journal of the American Chemical Society. PMID 28780854 DOI: 10.1021/jacs.7b06186  0.44
2017 Müller TA, Tobar MA, Perian MN, Hausinger RP. Biochemical Characterization of AP Lyase and m(6)A Demethylase Activities of Human AlkB Homologue 1 (ALKBH1). Biochemistry. PMID 28290676 DOI: 10.1021/acs.biochem.7b00060  0.4
2017 Walker AR, Silvestrov P, Müller TA, Podolsky RH, Dyson G, Hausinger RP, Cisneros GA. ALKBH7 Variant Related to Prostate Cancer Exhibits Altered Substrate Binding. Plos Computational Biology. 13: e1005345. PMID 28231280 DOI: 10.1371/journal.pcbi.1005345  0.4
2016 Martin-Diaconescu V, Joseph CA, Boer JL, Mulrooney SB, Hausinger RP, Maroney MJ. Non-thiolate ligation of nickel by nucleotide-free UreG of Klebsiella aerogenes. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. PMID 28004186 DOI: 10.1007/s00775-016-1429-9  1
2016 Proshlyakov DA, McCracken J, Hausinger RP. Spectroscopic analyses of 2-oxoglutarate-dependent oxygenases: TauD as a case study. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. PMID 27812832 DOI: 10.1007/s00775-016-1406-3  0.56
2016 Desguin B, Soumillion P, Hols P, Hausinger RP. Nickel-pincer cofactor biosynthesis involves LarB-catalyzed pyridinium carboxylation and LarE-dependent sacrificial sulfur insertion. Proceedings of the National Academy of Sciences of the United States of America. PMID 27114550 DOI: 10.1073/pnas.1600486113  1
2015 Farrugia MA, Wang B, Feig M, Hausinger RP. Mutational and Computational Evidence That a Nickel-Transfer Tunnel in UreD Is Used for Activation of Klebsiella aerogenes Urease. Biochemistry. PMID 26401965 DOI: 10.1021/acs.biochem.5b00942  1
2015 Martinez S, Hausinger RP. Catalytic Mechanisms of Fe(II)- and 2-Oxoglutarate-dependent Oxygenases. The Journal of Biological Chemistry. 290: 20702-11. PMID 26152721 DOI: 10.1074/jbc.R115.648691  1
2015 Desguin B, Zhang T, Soumillion P, Hols P, Hu J, Hausinger RP. METALLOPROTEINS. A tethered niacin-derived pincer complex with a nickel-carbon bond in lactate racemase. Science (New York, N.Y.). 349: 66-9. PMID 26138974 DOI: 10.1126/science.aab2272  1
2015 Henderson KL, Müller TA, Hausinger RP, Emerson JP. Calorimetric assessment of Fe(2+) binding to α-ketoglutarate/taurine dioxygenase: ironing out the energetics of metal coordination by the 2-His-1-carboxylate facial triad. Inorganic Chemistry. 54: 2278-83. PMID 25668068 DOI: 10.1021/ic502881q  1
2015 Macomber L, Minkara MS, Hausinger RP, Merz KM. Reduction of urease activity by interaction with the flap covering the active site. Journal of Chemical Information and Modeling. 55: 354-61. PMID 25594724 DOI: 10.1021/ci500562t  1
2015 Müller TA, Hausinger RP. AlkB and its homologues - DNA repair and beyond Rsc Metallobiology. 2015: 246-262. DOI: 10.1039/9781782621959-00246  1
2015 Hausinger RP. Biochemical diversity of 2-oxoglutarate-dependent oxygenases Rsc Metallobiology. 2015: 1-58. DOI: 10.1039/9781782621959-00001  1
2014 Silvestrov P, Müller TA, Clark KN, Hausinger RP, Cisneros GA. Homology modeling, molecular dynamics, and site-directed mutagenesis study of AlkB human homolog 1 (ALKBH1). Journal of Molecular Graphics & Modelling. 54: 123-30. PMID 25459764 DOI: 10.1016/j.jmgm.2014.10.013  1
2014 Yu H, Hausinger RP, Tang HZ, Xu P. Mechanism of the 6-hydroxy-3-succinoyl-pyridine 3-monooxygenase flavoprotein from Pseudomonas putida S16. The Journal of Biological Chemistry. 289: 29158-70. PMID 25172510 DOI: 10.1074/jbc.M114.558049  1
2014 Boer JL, Mulrooney SB, Hausinger RP. Nickel-dependent metalloenzymes. Archives of Biochemistry and Biophysics. 544: 142-52. PMID 24036122 DOI: 10.1016/  1
2014 Masukawa H, Sakurai H, Hausinger RP, Inoue K. Sustained photobiological hydrogen production in the presence of N2 by nitrogenase mutants of the heterocyst-forming cyanobacterium Anabaena International Journal of Hydrogen Energy. 39: 19444-19451. DOI: 10.1016/j.ijhydene.2014.09.090  1
2013 Casey TM, Grzyska PK, Hausinger RP, McCracken J. Measuring the orientation of taurine in the active site of the non-heme Fe(II)/α-ketoglutarate-dependent taurine hydroxylase (TauD) using electron spin echo envelope modulation (ESEEM) spectroscopy. The Journal of Physical Chemistry. B. 117: 10384-94. PMID 23937570 DOI: 10.1021/jp404743d  1
2013 Müller TA, Yu K, Hausinger RP, Meek K. ALKBH1 is dispensable for abasic site cleavage during base excision repair and class switch recombination. Plos One. 8: e67403. PMID 23825659 DOI: 10.1371/journal.pone.0067403  1
2013 Farrugia MA, Han L, Zhong Y, Boer JL, Ruotolo BT, Hausinger RP. Analysis of a soluble (UreD:UreF:UreG)2 accessory protein complex and its interactions with Klebsiella aerogenes urease by mass spectrometry. Journal of the American Society For Mass Spectrometry. 24: 1328-37. PMID 23797863 DOI: 10.1007/s13361-013-0677-y  1
2013 Müller TA, Andrzejak MM, Hausinger RP. A covalent protein-DNA 5'-product adduct is generated following AP lyase activity of human ALKBH1 (AlkB homologue 1). The Biochemical Journal. 452: 509-18. PMID 23577621 DOI: 10.1042/BJ20121908  1
2013 Farrugia MA, Macomber L, Hausinger RP. Biosynthesis of the urease metallocenter. The Journal of Biological Chemistry. 288: 13178-85. PMID 23539618 DOI: 10.1074/jbc.R112.446526  1
2012 Simmons JM, Koslowsky DJ, Hausinger RP. Characterization of a Trypanosoma brucei Alkb homolog capable of repairing alkylated DNA. Experimental Parasitology. 131: 92-100. PMID 22465611 DOI: 10.1016/j.exppara.2012.03.011  1
2012 Masukawa H, Kitashima M, Inoue K, Sakurai H, Hausinger RP. Genetic engineering of cyanobacteria to enhance biohydrogen production from sunlight and water. Ambio. 41: 169-73. PMID 22434447 DOI: 10.1007/s13280-012-0275-4  1
2012 Boer JL, Hausinger RP. Klebsiella aerogenes UreF: identification of the UreG binding site and role in enhancing the fidelity of urease activation. Biochemistry. 51: 2298-308. PMID 22369361 DOI: 10.1021/bi3000897  1
2012 Carter EL, Proshlyakov DA, Hausinger RP. Apoprotein isolation and activation, and vibrational structure of the Helicobacter mustelae iron urease. Journal of Inorganic Biochemistry. 111: 195-202. PMID 22196017 DOI: 10.1016/j.jinorgbio.2011.10.016  1
2011 Macomber L, Elsey SP, Hausinger RP. Fructose-1,6-bisphosphate aldolase (class II) is the primary site of nickel toxicity in Escherichia coli. Molecular Microbiology. 82: 1291-300. PMID 22014167 DOI: 10.1111/j.1365-2958.2011.07891.x  1
2011 Carter EL, Boer JL, Farrugia MA, Flugga N, Towns CL, Hausinger RP. Function of UreB in Klebsiella aerogenes urease. Biochemistry. 50: 9296-308. PMID 21939280 DOI: 10.1021/bi2011064  1
2011 Macomber L, Hausinger RP. Mechanisms of nickel toxicity in microorganisms. Metallomics : Integrated Biometal Science. 3: 1153-62. PMID 21799955 DOI: 10.1039/c1mt00063b  1
2011 Carter EL, Tronrud DE, Taber SR, Karplus PA, Hausinger RP. Iron-containing urease in a pathogenic bacterium. Proceedings of the National Academy of Sciences of the United States of America. 108: 13095-9. PMID 21788478 DOI: 10.1073/pnas.1106915108  1
2011 Mulrooney SB, Howard MJ, Hausinger RP. The Escherichia coli alkylation response protein AidB is a redox partner of flavodoxin and binds RNA and acyl carrier protein. Archives of Biochemistry and Biophysics. 513: 81-6. PMID 21782785 DOI: 10.1016/  1
2010 Masukawa H, Inoue K, Sakurai H, Wolk CP, Hausinger RP. Site-directed mutagenesis of the Anabaena sp. strain PCC 7120 nitrogenase active site to increase photobiological hydrogen production. Applied and Environmental Microbiology. 76: 6741-50. PMID 20709836 DOI: 10.1128/AEM.01056-10  1
2010 Lam R, Romanov V, Johns K, Battaile KP, Wu-Brown J, Guthrie JL, Hausinger RP, Pai EF, Chirgadze NY. Crystal structure of a truncated urease accessory protein UreF from Helicobacter pylori. Proteins. 78: 2839-48. PMID 20635345 DOI: 10.1002/prot.22802  1
2010 Boer JL, Quiroz-Valenzuela S, Anderson KL, Hausinger RP. Mutagenesis of Klebsiella aerogenes UreG to probe nickel binding and interactions with other urease-related proteins. Biochemistry. 49: 5859-69. PMID 20533838 DOI: 10.1021/bi1004987  1
2010 Carter EL, Hausinger RP. Characterization of the Klebsiella aerogenes urease accessory protein UreD in fusion with the maltose binding protein. Journal of Bacteriology. 192: 2294-304. PMID 20207756 DOI: 10.1128/JB.01426-09  1
2010 Grzyska PK, Appelman EH, Hausinger RP, Proshlyakov DA. Insight into the mechanism of an iron dioxygenase by resolution of steps following the FeIV=HO species. Proceedings of the National Academy of Sciences of the United States of America. 107: 3982-7. PMID 20147623 DOI: 10.1073/pnas.0911565107  1
2010 Müller TA, Meek K, Hausinger RP. Human AlkB homologue 1 (ABH1) exhibits DNA lyase activity at abasic sites. Dna Repair. 9: 58-65. PMID 19959401 DOI: 10.1016/j.dnarep.2009.10.011  1
2010 Simmons JM, Koslowsky DJ, Hausinger RP. Trypanosoma brucei brucei: thymine 7-hydroxylase-like proteins. Experimental Parasitology. 124: 453-8. PMID 19945457 DOI: 10.1016/j.exppara.2009.11.012  1
2010 Grzyska PK, Hausinger RP, Proshlyakov DA. Metal and substrate binding to an Fe(II) dioxygenase resolved by UV spectroscopy with global regression analysis. Analytical Biochemistry. 399: 64-71. PMID 19932076 DOI: 10.1016/j.ab.2009.11.022  1
2009 Carter EL, Flugga N, Boer JL, Mulrooney SB, Hausinger RP. Interplay of metal ions and urease. Metallomics : Integrated Biometal Science. 1: 207-21. PMID 20046957 DOI: 10.1039/b903311d  1
2008 Quiroz-Valenzuela S, Sukuru SC, Hausinger RP, Kuhn LA, Heller WT. The structure of urease activation complexes examined by flexibility analysis, mutagenesis, and small-angle X-ray scattering. Archives of Biochemistry and Biophysics. 480: 51-7. PMID 18823937 DOI: 10.1016/  1
2008 Simmons JM, Müller TA, Hausinger RP. Fe(II)/alpha-ketoglutarate hydroxylases involved in nucleobase, nucleoside, nucleotide, and chromatin metabolism. Dalton Transactions (Cambridge, England : 2003). 5132-42. PMID 18813363 DOI: 10.1039/b803512a  1
2008 Kalliri E, Mulrooney SB, Hausinger RP. Identification of Escherichia coli YgaF as an L-2-hydroxyglutarate oxidase. Journal of Bacteriology. 190: 3793-8. PMID 18390652 DOI: 10.1128/JB.01977-07  1
2008 Li M, Müller TA, Fraser BA, Hausinger RP. Characterization of active site variants of xanthine hydroxylase from Aspergillus nidulans. Archives of Biochemistry and Biophysics. 470: 44-53. PMID 18036331 DOI: 10.1016/  1
2007 Grzyska PK, Hausinger RP. Cr(II) reactivity of taurine/alpha-ketoglutarate dioxygenase. Inorganic Chemistry. 46: 10087-92. PMID 17973473 DOI: 10.1021/ic700383q  1
2007 Grossoehme NE, Mulrooney SB, Hausinger RP, Wilcox DE. Thermodynamics of Ni2+, Cu2+, and Zn2+ binding to the urease metallochaperone UreE. Biochemistry. 46: 10506-16. PMID 17711301 DOI: 10.1021/bi700171v  1
2007 Muthukumaran RB, Grzyska PK, Hausinger RP, McCracken J. Probing the iron-substrate orientation for taurine/alpha-ketoglutarate dioxygenase using deuterium electron spin echo envelope modulation spectroscopy. Biochemistry. 46: 5951-9. PMID 17469855 DOI: 10.1021/bi700562t  1
2007 Montero-Morán GM, Li M, Rendòn-Huerta E, Jourdan F, Lowe DJ, Stumpff-Kane AW, Feig M, Scazzocchio C, Hausinger RP. Purification and characterization of the FeII- and alpha-ketoglutarate-dependent xanthine hydroxylase from Aspergillus nidulans. Biochemistry. 46: 5293-304. PMID 17429948 DOI: 10.1021/bi700065h  1
2007 Yu Z, Genest PA, ter Riet B, Sweeney K, DiPaolo C, Kieft R, Christodoulou E, Perrakis A, Simmons JM, Hausinger RP, van Luenen HG, Rigden DJ, Sabatini R, Borst P. The protein that binds to DNA base J in trypanosomatids has features of a thymidine hydroxylase. Nucleic Acids Research. 35: 2107-15. PMID 17389644 DOI: 10.1093/nar/gkm049  1
2007 Grzyska PK, Müller TA, Campbell MG, Hausinger RP. Metal ligand substitution and evidence for quinone formation in taurine/alpha-ketoglutarate dioxygenase. Journal of Inorganic Biochemistry. 101: 797-808. PMID 17350690 DOI: 10.1016/j.jinorgbio.2007.01.011  1
2007 Hausinger RP. New insights into acetone metabolism. Journal of Bacteriology. 189: 671-3. PMID 17142393 DOI: 10.1128/JB.01578-06  1
2007 Quiroz S, Kim JK, Mulrooney SB, Hausinger RP. Chaperones of Nickel Metabolism Nickel and Its Surprising Impact in Nature. 2: 519-544. DOI: 10.1002/9780470028131.ch14  1
2006 Kim JK, Mulrooney SB, Hausinger RP. The UreEF fusion protein provides a soluble and functional form of the UreF urease accessory protein. Journal of Bacteriology. 188: 8413-20. PMID 17041056 DOI: 10.1128/JB.01265-06  1
2006 Zhang L, Mulrooney SB, Leung AF, Zeng Y, Ko BB, Hausinger RP, Sun H. Inhibition of urease by bismuth(III): implications for the mechanism of action of bismuth drugs. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. 19: 503-11. PMID 16937256 DOI: 10.1007/s10534-005-5449-0  1
2006 Müller TA, Zavodszky MI, Feig M, Kuhn LA, Hausinger RP. Structural basis for the enantiospecificities of R- and S-specific phenoxypropionate/alpha-ketoglutarate dioxygenases. Protein Science : a Publication of the Protein Society. 15: 1356-68. PMID 16731970 DOI: 10.1110/ps.052059406  1
2006 Luo L, Pappalardi MB, Tummino PJ, Copeland RA, Fraser ME, Grzyska PK, Hausinger RP. An assay for Fe(II)/2-oxoglutarate-dependent dioxygenases by enzyme-coupled detection of succinate formation. Analytical Biochemistry. 353: 69-74. PMID 16643838 DOI: 10.1016/j.ab.2006.03.033  1
2006 Rohankhedkar MS, Mulrooney SB, Wedemeyer WJ, Hausinger RP. The AidB component of the Escherichia coli adaptive response to alkylating agents is a flavin-containing, DNA-binding protein. Journal of Bacteriology. 188: 223-30. PMID 16352838 DOI: 10.1128/JB.188.1.223-230.2006  1
2006 Koehntop KD, Marimanikkuppam S, Ryle MJ, Hausinger RP, Que L. Self-hydroxylation of taurine/alpha-ketoglutarate dioxygenase: evidence for more than one oxygen activation mechanism. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 11: 63-72. PMID 16320009 DOI: 10.1007/s00775-005-0059-4  1
2005 Kim JK, Mulrooney SB, Hausinger RP. Biosynthesis of active Bacillus subtilis urease in the absence of known urease accessory proteins. Journal of Bacteriology. 187: 7150-4. PMID 16199586 DOI: 10.1128/JB.187.20.7150-7154.2005  1
2005 Kalliri E, Grzyska PK, Hausinger RP. Kinetic and spectroscopic investigation of CoII, NiII, and N-oxalylglycine inhibition of the FeII/alpha-ketoglutarate dioxygenase, TauD. Biochemical and Biophysical Research Communications. 338: 191-7. PMID 16165092 DOI: 10.1016/j.bbrc.2005.08.223  1
2005 Mulrooney SB, Ward SK, Hausinger RP. Purification and properties of the Klebsiella aerogenes UreE metal-binding domain, a functional metallochaperone of urease. Journal of Bacteriology. 187: 3581-5. PMID 15866948 DOI: 10.1128/JB.187.10.3581-3585.2005  1
2005 Grzyska PK, Ryle MJ, Monterosso GR, Liu J, Ballou DP, Hausinger RP. Steady-state and transient kinetic analyses of taurine/alpha-ketoglutarate dioxygenase: effects of oxygen concentration, alternative sulfonates, and active-site variants on the FeIV-oxo intermediate. Biochemistry. 44: 3845-55. PMID 15751960 DOI: 10.1021/bi048746n  1
2004 Henshaw TF, Feig M, Hausinger RP. Aberrant activity of the DNA repair enzyme AlkB. Journal of Inorganic Biochemistry. 98: 856-61. PMID 15134932 DOI: 10.1016/j.jinorgbio.2003.10.021  1
2004 Hausinger RP. FeII/alpha-ketoglutarate-dependent hydroxylases and related enzymes. Critical Reviews in Biochemistry and Molecular Biology. 39: 21-68. PMID 15121720 DOI: 10.1080/10409230490440541  1
2004 Hausinger RP. Metabolic versatility of prokaryotes for urea decomposition. Journal of Bacteriology. 186: 2520-2. PMID 15090490 DOI: 10.1128/JB.186.9.2520-2522.2004  1
2004 Kuchar J, Hausinger RP. Biosynthesis of metal sites. Chemical Reviews. 104: 509-25. PMID 14871133 DOI: 10.1021/cr020613p  1
2004 Chang Z, Kuchar J, Hausinger RP. Chemical cross-linking and mass spectrometric identification of sites of interaction for UreD, UreF, and urease. The Journal of Biological Chemistry. 279: 15305-13. PMID 14749331 DOI: 10.1074/jbc.M312979200  1
2004 Proshlyakov DA, Henshaw TF, Monterosso GR, Ryle MJ, Hausinger RP. Direct detection of oxygen intermediates in the non-heme Fe enzyme taurine/alpha-ketoglutarate dioxygenase. Journal of the American Chemical Society. 126: 1022-3. PMID 14746461 DOI: 10.1021/ja039113j  1
2003 Mulrooney SB, Hausinger RP. Nickel uptake and utilization by microorganisms. Fems Microbiology Reviews. 27: 239-61. PMID 12829270 DOI: 10.1016/S0168-6445(03)00042-1  1
2003 Hausinger RP. Ni and CO: more surprises. Nature Structural Biology. 10: 234-6. PMID 12660715 DOI: 10.1038/nsb0403-234  1
2003 Ryle MJ, Koehntop KD, Liu A, Que L, Hausinger RP. Interconversion of two oxidized forms of taurine/alpha-ketoglutarate dioxygenase, a non-heme iron hydroxylase: evidence for bicarbonate binding. Proceedings of the National Academy of Sciences of the United States of America. 100: 3790-5. PMID 12642663 DOI: 10.1073/pnas.0636740100  1
2003 Ryle MJ, Liu A, Muthukumaran RB, Ho RY, Koehntop KD, McCracken J, Que L, Hausinger RP. O2- and alpha-ketoglutarate-dependent tyrosyl radical formation in TauD, an alpha-keto acid-dependent non-heme iron dioxygenase. Biochemistry. 42: 1854-62. PMID 12590572 DOI: 10.1021/bi026832m  1
2003 Dunning Hotopp JC, Auchtung TA, Hogan DA, Hausinger RP. Intrinsic tryptophan fluorescence as a probe of metal and alpha-ketoglutarate binding to TfdA, a mononuclear non-heme iron dioxygenase. Journal of Inorganic Biochemistry. 93: 66-70. PMID 12538054 DOI: 10.1016/S0162-0134(02)00436-1  1
2003 Mulrooney SB, Hausinger RP. Metal ion dependence of recombinant Escherichia coli allantoinase. Journal of Bacteriology. 185: 126-34. PMID 12486048 DOI: 10.1128/JB.185.1.126-134.2003  1
2002 Trewick SC, Henshaw TF, Hausinger RP, Lindahl T, Sedgwick B. Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage. Nature. 419: 174-8. PMID 12226667 DOI: 10.1038/nature00908  1
2002 Dunning Hotopp JC, Hausinger RP. Probing the 2,4-dichlorophenoxyacetate/alpha-ketoglutarate dioxygenase substrate-binding site by site-directed mutagenesis and mechanism-based inactivation. Biochemistry. 41: 9787-94. PMID 12146944 DOI: 10.1021/bi026057a  1
2002 Itoh K, Kanda R, Sumita Y, Kim H, Kamagata Y, Suyama K, Yamamoto H, Hausinger RP, Tiedje JM. tfdA-like genes in 2,4-dichlorophenoxyacetic acid-degrading bacteria belonging to the Bradyrhizobium-Agromonas-Nitrobacter-Afipia cluster in alpha-Proteobacteria. Applied and Environmental Microbiology. 68: 3449-54. PMID 12089027 DOI: 10.1128/AEM.68.7.3449-3454.2002  1
2002 Ryle MJ, Hausinger RP. Non-heme iron oxygenases. Current Opinion in Chemical Biology. 6: 193-201. PMID 12039004 DOI: 10.1016/S1367-5931(02)00302-2  1
2002 Elkins JM, Ryle MJ, Clifton IJ, Dunning Hotopp JC, Lloyd JS, Burzlaff NI, Baldwin JE, Hausinger RP, Roach PL. X-ray crystal structure of Escherichia coli taurine/alpha-ketoglutarate dioxygenase complexed to ferrous iron and substrates. Biochemistry. 41: 5185-92. PMID 11955067 DOI: 10.1021/bi016014e  1
2001 Mulrooney S, Zakharian T, Schaller RA, Hausinger RP. Dual effects of ionic strength on Klebsiella aerogenes urease: pH-dependent activation and inhibition Archives of Biochemistry and Biophysics. 394: 280-282. PMID 11594743 DOI: 10.1006/abbi.2001.2536  1
2001 Song HK, Mulrooney SB, Huber R, Hausinger RP. Crystal structure of Klebsiella aerogenes UreE, a nickel-binding metallochaperone for urease activation. The Journal of Biological Chemistry. 276: 49359-64. PMID 11591723 DOI: 10.1074/jbc.M108619200  1
2001 Ho RY, Mehn MP, Hegg EL, Liu A, Ryle MJ, Hausinger RP, Que L. Resonance Raman studies of the iron(II)--alpha-keto acid chromophore in model and enzyme complexes. Journal of the American Chemical Society. 123: 5022-9. PMID 11457330 DOI: 10.1021/ja0041775  1
2001 Dunning Hotopp JC, Hausinger RP. Alternative substrates of 2,4-dichlorophenoxyacetate/α-ketoglutarate dioxygenase Journal of Molecular Catalysis - B Enzymatic. 15: 155-162. DOI: 10.1016/S1381-1177(01)00018-2  1
2000 Soriano A, Colpas GJ, Hausinger RP. UreE stimulation of GTP-dependent urease activation in the UreD-UreF-UreG-urease apoprotein complex Biochemistry. 39: 12435-12440. PMID 11015224 DOI: 10.1021/bi001296o  1
2000 Pearson MA, Park IS, Schaller RA, Michel LO, Karplus PA, Hausinger RP. Kinetic and structural characterization of urease active site variants. Biochemistry. 39: 8575-84. PMID 10913264 DOI: 10.1021/bi000613o  1
2000 Todd MJ, Hausinger RP. Fluoride inhibition of Klebsiella aerogenes urease: Mechanistic implications of a pseudo-uncompetitive, slow-binding inhibitor Biochemistry. 39: 5389-5396. PMID 10820010 DOI: 10.1021/bi992287m  1
2000 Hogani DA, Smith SR, Saari EA, McCracken J, Hausinger RP. Site-directed mutagenesis of 2,4-dichlorophenoxyacetic acid/α- ketoglutarate dioxygenase. Identification of residues involved in metallocenter formation and substrate binding Journal of Biological Chemistry. 275: 12400-12409. PMID 10777523 DOI: 10.1074/jbc.275.17.12400  1
2000 Colpas GJ, Hausinger RP. In vivo and in vitro kinetics of metal transfer by the Klebsiella aerogenes urease nickel metallochaperone, UreE Journal of Biological Chemistry. 275: 10731-10737. PMID 10753863 DOI: 10.1074/jbc.275.15.10731  1
1999 Hegg EL, Whiting AK, Saari RE, McCracken J, Hausinger RP, Que L. Herbicide-degrading α-keto acid-dependent enzyme TfdA: Metal coordination environment and mechanistic insights Biochemistry. 38: 16714-16726. PMID 10600135 DOI: 10.1021/bi991796l  1
1999 Ryle MJ, Padmakumar R, Hausinger RP. Stopped-flow kinetic analysis of Escherichia coli taurine/alpha-ketoglutarate dioxygenase: interactions with alpha-ketoglutarate, taurine, and oxygen. Biochemistry. 38: 15278-86. PMID 10563813 DOI: 10.1021/bi9912746  1
1999 Yamaguchi K, Cosper NJ, Stålhandske C, Scott RA, Pearson MA, Karplus PA, Hausinger RP. Characterization of metal-substituted Klebsiella aerogenes urease. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 4: 468-77. PMID 10555581 DOI: 10.1007/s007750050333  1
1999 Soriano A, Hausinger RP. GTP-dependent activation of urease apoprotein in complex with the UreD, UreF, and UreG accessory proteins Proceedings of the National Academy of Sciences of the United States of America. 96: 11140-11144. PMID 10500143 DOI: 10.1073/pnas.96.20.11140  1
1999 Cosper NJ, Stålhandske CMV, Saari RE, Hausinger RP, Scott RA. X-ray absorption spectroscopic analysis of Fe(II) and Cu(II) forms of a herbicide-degrading α-ketoglutarate dioxygenase Journal of Biological Inorganic Chemistry. 4: 122-129. PMID 10499109 DOI: 10.1007/s007750050295  1
1999 Hogan DA, Auchtung TA, Hausinger RP. Cloning and characterization of a sulfonate/α-ketoglutarate from dioxygenase from Saccharomyces cerevisiae Journal of Bacteriology. 181: 5876-5879. PMID 10482536  1
1999 Colpas GJ, Brayman TG, Ming LJ, Hausinger RP. Identification of metal-binding residues in the Klebsiella aerogenes urease nickel metallochaperone, ureE Biochemistry. 38: 4078-4088. PMID 10194322 DOI: 10.1021/bi982435t  1
1999 Romanov V, Merski MT, Hausinger RP. Assays for allantoinase. Analytical Biochemistry. 268: 49-53. PMID 10036161 DOI: 10.1006/abio.1998.3033  1
1999 Saari RE, Hogan DA, Hausinger RP. Stereospecific degradation of the phenoxypropionate herbicide dichlorprop Journal of Molecular Catalysis - B Enzymatic. 6: 421-428. DOI: 10.1016/S1381-1177(99)00008-9  1
1998 Pearson MA, Schaller RA, Michel LO, Karplus PA, Hausinger RP. Chemical rescue of Klebsiella aerogenes urease variants lacking the carbamylated-lysine nickel ligand Biochemistry. 37: 6214-6220. PMID 9558361 DOI: 10.1021/bi980021u  1
1998 Saari RE, Hausinger RP. Ascorbic acid-dependent turnover and reactivation of 2,4- dichlorophenoxyacetic acid/α-ketoglutarate dioxygenase using thiophenoxyacetic acid Biochemistry. 37: 3035-3042. PMID 9485456 DOI: 10.1021/bi972388p  1
1998 Colpas GJ, Brayman TG, McCracken J, Pressler MA, Babcock GT, Ming LJ, Colangelo CM, Scott RA, Hausinger RP. Spectroscopic characterization of metal binding by Klebsiella aerogenes UreE urease accessory protein Journal of Biological Inorganic Chemistry. 3: 150-160. DOI: 10.1007/s007750050216  1
1997 Yamaguchi K, Hausinger RP. Substitution of the urease active site carbamate by dithiocarbamate and vanadate Biochemistry. 36: 15118-15122. PMID 9398239 DOI: 10.1021/bi971767f  1
1997 Moncrief MBC, Hausinger RP. Characterization of UreG, identification of a UreD-UreF-UreG complex, and evidence suggesting that a nucleotide-binding site in UreG is required for in vivo metallocenter assembly of Klebsiella aerogenes urease Journal of Bacteriology. 179: 4081-4086. PMID 9209019  1
1997 Pearson MA, Michel LO, Hausinger RP, Karplus PA. Structures of Cys319 variants and acetohydroxamate-inhibited Klebsiella aerogenes urease Biochemistry. 36: 8164-8172. PMID 9201965 DOI: 10.1021/bi970514j  1
1997 Whiting AK, Que L. J, Saari RE, Hausinger RP, Fredrick MA, McCracken J. Metal coordination environment of a Cu(II)-substituted α-keto acid-dependent dioxygenase that degrades the herbicide 2,4-D Journal of the American Chemical Society. 119: 3413-3414. DOI: 10.1021/ja964449x  1
1997 Hausinger RP. Metallocenter assembly in nickel-containing enzymes Journal of Biological Inorganic Chemistry. 2: 279-286. DOI: 10.1007/s007750050133  1
1997 Hogan DA, Buckley DH, Nakatsu CH, Schmidt TM, Hausinger RP. Distribution of the tfda gene in soil bacteria that do not degrade 2,4-dichlorophenoxyacetic acid (2,4-D) Microbial Ecology. 34: 90-96. DOI: 10.1007/s002489900038  1
1997 Karplus PA, Pearson MA, Hausinger RP. 70 Years of Crystalline Urease: What Have We Learned? Accounts of Chemical Research. 30: 330-337.  1
1997 Sassanella TM, Fukumori F, Bagdasarian M, Hausinger RP. Use of 4-nitrophenoxyacetic acid for detection and quantification of 2,4-dichlorophenoxyacetic acid (2,4-D)/α-ketoglutarate dioxygenase activity in 2,4-D-degrading microorganisms Applied and Environmental Microbiology. 63: 1189-1191.  1
1996 Moncrief MBC, Hausinger RP. Purification and activation properties of UreD-UreF-Urease apoprotein complexes Journal of Bacteriology. 178: 5417-5421. PMID 8808930  1
1996 Brayman TG, Hausinger RP. Purification, characterization, and functional analysis of a truncated Klebsiella aerogenes UreE urease accessory protein lacking the histidine- rich carboxyl terminus Journal of Bacteriology. 178: 5410-5416. PMID 8808929  1
1996 Suwa Y, Wright AD, Fukimori F, Nummy KA, Hausinger RP, Holben WE, Forney LJ. Characterization of a chromosomally encoded 2,4-dichlorophenoxyacetic acid/alpha-ketoglutarate dioxygenase from Burkholderia sp. strain RASC. Applied and Environmental Microbiology. 62: 2464-9. PMID 8779585  1
1996 Park IS, Michel LO, Pearson MA, Jabri E, Karplus PA, Wang S, Dong J, Scott RA, Koehler BP, Johnson MK, Hausinger RP. Characterization of the mononickel metallocenter in H134A mutant urease. The Journal of Biological Chemistry. 271: 18632-7. PMID 8702515 DOI: 10.1074/jbc.271.31.18632  1
1996 Romanov V, Hausinger RP. NADPH-dependent reductive ortho dehalogenation of 2,4-dichlorobenzoic acid in Corynebacterium sepedonicum KZ-4 and coryneform bacterium strain NTB-1 via 2,4-dichlorobenzoyl coenzyme A Journal of Bacteriology. 178: 2656-2661. PMID 8626335  1
1996 Park IS, Hausinger RP. Metal ion interactions with urease and ureD-urease apoproteins Biochemistry. 35: 5345-5352. PMID 8611523 DOI: 10.1021/bi952894j  1
1995 Hausinger RP, Fukumori F. Characterization of the first enzyme in 2,4-dichlorophenoxyacetic acid metabolism Environmental Health Perspectives. 103: 37-39. PMID 8565907  1
1995 Moncrief MBC, Hom LG, Jabri E, Karplus PA, Hausinger RP. Urease activity in the crystalline state Protein Science. 4: 2234-2236. PMID 8535259  1
1995 Park IS, Hausinger RP. Requirement of carbon dioxide for in vitro assembly of the urease nickel metallocenter Science. 267: 1156-1158. PMID 7855593  1
1995 Jabri E, Carr MB, Hausinger RP, Karplus PA. The crystal structure of urease from Klebsiella aerogenes Science. 268: 998-1004. PMID 7754395  1
1995 Park IS, Hausinger RP. Evidence for the presence of urease apoprotein complexes containing UreD, UreF, and UreG in cells that are competent for in vivo enzyme activation Journal of Bacteriology. 177: 1947-1951. PMID 7721685  1
1995 Mobley HLT, Island MD, Hausinger RP. Molecular biology of microbial ureases Microbiological Reviews. 59: 451-480. PMID 7565414  1
1994 Romanov V, Hausinger RP. Pseudomonas aeruginosa 142 uses a three-component ortho-halobenzoate 1,2- dioxygenase for metabolism of 2,4-dichloro- and 2-chlorobenzoate Journal of Bacteriology. 176: 3368-3374. PMID 8195093  1
1994 Hausinger RP. Nickel enzymes in microbes Science of the Total Environment, The. 148: 157-166. PMID 8029691 DOI: 10.1016/0048-9697(94)90392-1  1
1994 Park IS, Carr MB, Hausinger RP. In vitro activation of urease apoprotein and role of UreD as a chaperone required for nickel metallocenter assembly Proceedings of the National Academy of Sciences of the United States of America. 91: 3233-3237. PMID 7909161  1
1994 Wang S, Lee MH, Hausinger RP, Clark PA, Wilcox DE, Scott RA. Structure of the dinuclear active site of urease. X-ray absorption spectroscopic study of native and 2-mercaptoethanol-inhibited bacterial and plant enzymes Inorganic Chemistry. 33: 1589-1593.  1
1993 Fukumori F, Hausinger RP. Alcaligenes eutrophus JMP134 '2,4-dichlorophenoxyacetate monooxygenase' is an α-ketoglutarate-dependent dioxygenase Journal of Bacteriology. 175: 2083-2086. PMID 8458850  1
1993 Park IS, Hausinger RP. Diethylpyrocarbonate reactivity of Klebsiella aerogenes urease: Effect of pH and active site ligands on the rate of inactivation Journal of Protein Chemistry. 12: 51-56. PMID 8427633 DOI: 10.1007/BF01024914  1
1993 Mann Hyung Lee, Pankratz HS, Wang S, Scott RA, Finnegan MG, Johnson MK, Ippolito JA, Christianson DW, Hausinger RP. Purification and characterization of Klebsiella aerogenes UreE protein: A nickel-binding protein that functions in urease metallocenter assembly Protein Science. 2: 1042-1052. PMID 8318889  1
1993 Park IS, Hausinger RP. Site-directed mutagenesis of Klebsiella aerogenes urease: Identification of histidine residues that appear to function in nickel ligation, substrate binding, and catalysis Protein Science. 2: 1034-1041. PMID 8318888  1
1993 Fukumori F, Hausinger RP. Purification and characterization of 2,4-dichlorophenoxyacetate/α-ketoglutarate dioxygenase Journal of Biological Chemistry. 268: 24311-24317. PMID 8226980  1
1993 Day EP, Peterson J, Sendova MS, Todd MJ, Hausinger RP. Saturation magnetization of ureases from klebsiella aerogenes and jack bean: No evidence for exchange coupling between the two active site Nickel ions in the native enzymes Inorganic Chemistry. 32: 634-638. DOI: 10.1021/ic00057a024  1
1992 Mann Hyung Lee, Mulrooney SB, Renner MJ, Markowicz Y, Hausinger RP. Klebsiella aerogenes urease gene cluster: Sequence of ureD and demonstration that four accessory genes (ureD, ureE, ureF, and ureG) are involved in nickel metallocenter biosynthesis Journal of Bacteriology. 174: 4324-4330. PMID 1624427  1
1992 McCoy DD, Cetin A, Hausinger RP. Characterization of urease from Sporosarcina ureae. Archives of Microbiology. 157: 411-6. PMID 1510567 DOI: 10.1007/BF00249097  1
1992 Jabri E, Lee MH, Hausinger RP, Karplus PA. Preliminary crystallographic studies of urease from jack bean and from Klebsiella aerogenes Journal of Molecular Biology. 227: 934-937. PMID 1404395 DOI: 10.1016/0022-2836(92)90232-9  1
1992 Martin PR, Hausinger RP. Site-directed mutagenesis of the active site cysteine in Klebsiella aerogenes urease. The Journal of Biological Chemistry. 267: 20024-7. PMID 1400317  1
1991 Todd MJ, Hausinger RP. Reactivity of the essential thiol of Klebsiella aerogenes urease: Effect of pH and ligands on thiol modification Journal of Biological Chemistry. 266: 10260-10267. PMID 2037578  1
1991 Todd MJ, Hausinger RP. Identification of the essential cysteine residue in Klebsiella aerogenes urease Journal of Biological Chemistry. 266: 24327-24331. PMID 1761535  1
1990 Mulrooney SB, Hausinger RP. Sequence of the Klebsiella aerogenes urease genes and evidence for accessory proteins facilitating nickel incorporation Journal of Bacteriology. 172: 5837-5843. PMID 2211515  1
1990 Hausinger RP. Mechanisms of metal ion incorporation into metalloproteins Biofactors. 2: 179-184. PMID 2198877  1
1990 Lee MH, Mulrooney SB, Hausinger RP. Purification, characterization, and in vivo reconstitution of Klebsiella aerogenes urease apoenzyme Journal of Bacteriology. 172: 4427-4431. PMID 2142939  1
1989 Mulrooney SB, Pankratz HS, Hausinger RP. Regulation of gene expression and cellular localization of cloned Klebsiella aerogenes (K. pneumoniae) urease Journal of General Microbiology. 135: 1769-1776. PMID 2693604  1
1989 Todd MJ, Hausinger RP. Competitive inhibitors of Klebsiella aerogenes urease. Mechanisms of interaction with the nickel active site Journal of Biological Chemistry. 264: 15835-15842. PMID 2674118  1
1989 Mobley HLT, Hausinger RP. Microbial ureases: Significance, regulation, and molecular characterization Microbiological Reviews. 53: 85-108. PMID 2651866  1
1988 Frei JI, Cavanagh KT, Fisher RA, Hausinger RP, Dupuis M, Rathke EJ, Jones MZ. Partial purification of goat kidney beta-mannosidase. The Biochemical Journal. 249: 871-5. PMID 3355501  1
1988 Breitenbach JM, Hausinger RP. Proteus mirabilis urease. Partial purification and inhibition by boric acid and boronic acids Biochemical Journal. 250: 917-920. PMID 3291857  1
1988 Simpson DA, Hausinger RP, Mulks MH. Purification, characterization, and comparison of the immunoglobulin A1 proteases of Neisseria gonorrhoeae Journal of Bacteriology. 170: 1866-1873. PMID 3127382  1
1988 Gloss LM, Hausinger RP. Methanogen factor 390 formation: species distribution, reversibility and effects of non-oxidative cellular stresses Biofactors (Oxford, England). 1: 237-240. PMID 2855706  1
1988 Mulrooney SB, Lynch MJ, Mobley HL, Hausinger RP. Purification, characterization, and genetic organization of recombinant Providencia stuartii urease expressed by Escherichia coli Journal of Bacteriology. 170: 2202-2207. PMID 2834333  1
1987 Todd MJ, Hausinger RP. Purification and characterization of the nickel-containing multicomponent urease from Klebsiella aerogenes Journal of Biological Chemistry. 262: 5963-5967. PMID 3553184  1
1987 Hausinger RP. Nickel utilization by microorganisms Microbiological Reviews. 51: 22-42. PMID 3104749  1
1987 Gloss LM, Hausinger RP. Reduction potential characterization of methanogen factor 390 Fems Microbiology Letters. 48: 143-145.  1
1986 Hausinger RP. Purification of a nickel-containing urease from the rumen anaerobe Selenomonas ruminantium Journal of Biological Chemistry. 261: 7866-7870. PMID 3711113  1
1986 Hausinger RP, Honek JF, Walsh C. Separation of flavins and flavin analogs by high-performance liquid chromatography. Methods in Enzymology. 122: 199-209. PMID 3702688  1
1985 Hausinger RP, Orme-Johnson WH, Walsh C. Factor 390 chromophores: phosphodiester between AMP or GMP and methanogen factor 420. Biochemistry. 24: 1629-33. PMID 2988607  1
1984 Hausinger RP, Orme-Johnson WH, Walsh C. Nickel tetrapyrrole cofactor F430: Comparison of the forms bound to methyl coenzyme M reductase and protein free in cells of Methanobacterium thermoautotrophicum ΔH Biochemistry. 23: 801-804.  1
1984 Lindahl PA, Kojima N, Hausinger RP, Fox JA, Teo BK, Walsh CT, Orme-Johnson WH. Nickel and iron EXAFS of F420-reducing hydrogenase from Methanobacterium thermoautotrophicum Journal of the American Chemical Society. 106: 3062-3064.  1
1983 Hausinger RP, Howard JB. Thiol reactivity of the nitrogenase Fe-protein from Azotobacter vinelandii. The Journal of Biological Chemistry. 258: 13486-92. PMID 6580291  1
1983 Kojima N, Fox JA, Hausinger RP, Daniels L, Orme-Johnson WH, Walsh C. Paramagnetic centers in the nickel-containing, deazaflavin-reducing hydrogenase from Methanobacterium thermoautotrophicum. Proceedings of the National Academy of Sciences of the United States of America. 80: 378-82. PMID 6300837  1
1982 Hausinger RP, Howard JB. The amino acid sequence of the nitrogenase iron protein from Azotobacter vinelandii. The Journal of Biological Chemistry. 257: 2483-90. PMID 6801032  1
1982 Hausinger RP, Moura I, Moura JJ, Xavier AV, Santos MH, LeGall J, Howard JB. Amino acid sequence of a 3Fe:3S ferredoxin from the "archaebacterium" Methanosarcina barkeri (DSM 800). The Journal of Biological Chemistry. 257: 14192-7. PMID 6754724  1
1980 Hausinger RP, Howard JB. Comparison of the iron proteins from the nitrogen fixation complexes of Azotobacter vinelandii, Clostridium pasteurianum, and Klebsiella pneumoniae. Proceedings of the National Academy of Sciences of the United States of America. 77: 3826-30. PMID 7001444  1
1980 Moura I, Huynh BH, Hausinger RP, Le Gall J, Xavier AV, Münck E. Mössbauer and EPR studies of desulforedoxin from Desulfovibrio gigas Journal of Biological Chemistry. 255: 2493-2498. PMID 6244281  1
Show low-probability matches.