Patricia E. Ganey - Publications

Affiliations: 
Biochemistry and Molecular Biology - Environmental Toxicology Michigan State University, East Lansing, MI 
Area:
Toxicology

140 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Maiuri AR, Wassink B, Turkus JD, Breier AB, Lansdell T, Kaur G, Hession SL, Ganey PE, Roth RA. Synergistic Cytotoxicity from Drugs and Cytokines in Vitro as an Approach to Classify Drugs According to their Potential to Cause Idiosyncratic Hepatotoxicity: A Proof of Concept Study. The Journal of Pharmacology and Experimental Therapeutics. PMID 28687704 DOI: 10.1124/jpet.117.242354  0.76
2017 Roth RA, Maiuri AR, Ganey PE. Idiosyncratic Drug-Induced Liver Injury: Is Drug-Cytokine Interaction the Linchpin? The Journal of Pharmacology and Experimental Therapeutics. 360: 461-470. PMID 28104833 DOI: 10.1124/jpet.116.237578  0.76
2015 Maiuri AR, Breier AB, Turkus JD, Ganey PE, Roth RA. Calcium Contributes to the Cytotoxic Interaction between Diclofenac and Cytokines. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 26609140 DOI: 10.1093/toxsci/kfv249  0.76
2015 Miyakawa K, Joshi N, Sullivan BP, Albee R, Brandenberger C, Jaeschke H, McGill MR, Scott MA, Ganey PE, Luyendyk JP, Roth RA. Platelets and protease-activated receptor-4 contribute to acetaminophen-induced liver injury in mice. Blood. PMID 26179083 DOI: 10.1182/blood-2014-09-598656  0.76
2015 Miyakawa K, Albee R, Letzig LG, Lehner AF, Scott MA, Buchweitz JP, James LP, Ganey PE, Roth RA. A Cytochrome P450-Independent Mechanism of Acetaminophen-Induced Injury in Cultured Mouse Hepatocytes. The Journal of Pharmacology and Experimental Therapeutics. 354: 230-7. PMID 26065700 DOI: 10.1124/jpet.115.223537  0.76
2015 Maiuri AR, Breier AB, Gora LF, Parkins RV, Ganey PE, Roth RA. Cytotoxic Synergy Between Cytokines and NSAIDs Associated With Idiosyncratic Hepatotoxicity Is Driven by Mitogen-Activated Protein Kinases. Toxicological Sciences : An Official Journal of the Society of Toxicology. 146: 265-80. PMID 25953702 DOI: 10.1093/toxsci/kfv091  0.76
2015 Beggs KM, Maiuri AR, Fullerton AM, Poulsen KL, Breier AB, Ganey PE, Roth RA. Trovafloxacin-induced replication stress sensitizes HepG2 cells to tumor necrosis factor-alpha-induced cytotoxicity mediated by extracellular signal-regulated kinase and ataxia telangiectasia and Rad3-related. Toxicology. 331: 35-46. PMID 25748550 DOI: 10.1016/j.tox.2015.03.002  0.76
2015 Maiuri AR, Breier AB, Gora LFJ, Parkins RV, Ganey PE, Roth RA. Cytotoxic synergy between cytokines and NSAIDs associated with idiosyncratic hepatotoxicity is driven by mitogen-activated protein kinases Toxicological Sciences. 146: 265-280. DOI: 10.1093/toxsci/kfv091  0.76
2014 Poulsen KL, Olivero-Verbel J, Beggs KM, Ganey PE, Roth RA. Trovafloxacin enhances lipopolysaccharide-stimulated production of tumor necrosis factor-α by macrophages: role of the DNA damage response. The Journal of Pharmacology and Experimental Therapeutics. 350: 164-70. PMID 24817034 DOI: 10.1124/jpet.114.214189  0.76
2014 Poulsen KL, Albee RP, Ganey PE, Roth RA. Trovafloxacin potentiation of lipopolysaccharide-induced tumor necrosis factor release from RAW 264.7 cells requires extracellular signal-regulated kinase and c-Jun N-Terminal Kinase. The Journal of Pharmacology and Experimental Therapeutics. 349: 185-91. PMID 24525298 DOI: 10.1124/jpet.113.211276  0.76
2014 Beggs KM, Fullerton AM, Miyakawa K, Ganey PE, Roth RA. Molecular mechanisms of hepatocellular apoptosis induced by trovafloxacin-tumor necrosis factor-alpha interaction. Toxicological Sciences : An Official Journal of the Society of Toxicology. 137: 91-101. PMID 24097668 DOI: 10.1093/toxsci/kft226  0.76
2013 Fullerton AM, Roth RA, Ganey PE. Pretreatment with TCDD exacerbates liver injury from Concanavalin A: critical role for NK cells. Toxicological Sciences : An Official Journal of the Society of Toxicology. 136: 72-85. PMID 23970800 DOI: 10.1093/toxsci/kft174  0.76
2013 Lu J, Roth RA, Malle E, Ganey PE. Roles of the hemostatic system and neutrophils in liver injury from co-exposure to amiodarone and lipopolysaccharide. Toxicological Sciences : An Official Journal of the Society of Toxicology. 136: 51-62. PMID 23912913 DOI: 10.1093/toxsci/kft170  0.76
2013 Fullerton AM, Roth RA, Ganey PE. 2,3,7,8-TCDD enhances the sensitivity of mice to concanavalin A immune-mediated liver injury. Toxicology and Applied Pharmacology. 266: 317-27. PMID 23164664 DOI: 10.1016/j.taap.2012.11.009  0.76
2013 Lu J, Miyakawa K, Roth RA, Ganey PE. Tumor necrosis factor-alpha potentiates the cytotoxicity of amiodarone in Hepa1c1c7 cells: roles of caspase activation and oxidative stress. Toxicological Sciences : An Official Journal of the Society of Toxicology. 131: 164-78. PMID 23042730 DOI: 10.1093/toxsci/kfs289  0.76
2013 Roth RA, Ganey PE. Role of inflammation in drug-induced liver injury Drug-Induced Liver Disease. 157-173. DOI: 10.1016/B978-0-12-387817-5.00010-8  0.76
2012 Coen M, Rademacher PM, Zou W, Scott M, Ganey PE, Roth R, Nelson SD. Comparative NMR-based metabonomic investigation of the metabolic phenotype associated with tienilic acid and tienilic acid isomer. Chemical Research in Toxicology. 25: 2412-22. PMID 23013248 DOI: 10.1021/tx3002803  0.76
2012 Singhal R, Ganey PE, Roth RA. Complement activation in acetaminophen-induced liver injury in mice. The Journal of Pharmacology and Experimental Therapeutics. 341: 377-85. PMID 22319198 DOI: 10.1124/jpet.111.189837  0.76
2012 Sparkenbaugh EM, Ganey PE, Roth RA. Hypoxia sensitization of hepatocytes to neutrophil elastase-mediated cell death depends on MAPKs and HIF-1α. American Journal of Physiology. Gastrointestinal and Liver Physiology. 302: G748-57. PMID 22223132 DOI: 10.1152/ajpgi.00409.2011  0.76
2012 Lu J, Jones AD, Harkema JR, Roth RA, Ganey PE. Amiodarone exposure during modest inflammation induces idiosyncrasy-like liver injury in rats: role of tumor necrosis factor-alpha. Toxicological Sciences : An Official Journal of the Society of Toxicology. 125: 126-33. PMID 21984482 DOI: 10.1093/toxsci/kfr266  0.76
2011 Zou W, Roth RA, Younis HS, Malle E, Ganey PE. Neutrophil-cytokine interactions in a rat model of sulindac-induced idiosyncratic liver injury. Toxicology. 290: 278-85. PMID 22019926 DOI: 10.1016/j.tox.2011.10.005  0.76
2011 Roth RA, Ganey PE. Animal models of idiosyncratic drug-induced liver injury--current status. Critical Reviews in Toxicology. 41: 723-39. PMID 21726137 DOI: 10.3109/10408444.2011.575765  0.76
2011 Sparkenbaugh EM, Saini Y, Greenwood KK, LaPres JJ, Luyendyk JP, Copple BL, Maddox JF, Ganey PE, Roth RA. The role of hypoxia-inducible factor-1α in acetaminophen hepatotoxicity. The Journal of Pharmacology and Experimental Therapeutics. 338: 492-502. PMID 21576378 DOI: 10.1124/jpet.111.180521  0.76
2011 Dugan CM, Fullerton AM, Roth RA, Ganey PE. Natural killer cells mediate severe liver injury in a murine model of halothane hepatitis. Toxicological Sciences : An Official Journal of the Society of Toxicology. 120: 507-18. PMID 21245496 DOI: 10.1093/toxsci/kfr005  0.76
2011 Olivero-Verbel J, Roth RA, Ganey PE. Dioxin alters inflammatory responses to lipopolysaccharide Toxicological and Environmental Chemistry. 93: 1180-1194. DOI: 10.1080/02772248.2011.577554  0.76
2010 Liguori MJ, Ditewig AC, Maddox JF, Luyendyk JP, Lehman-McKeeman LD, Nelson DM, Bhaskaran VM, Waring JF, Ganey PE, Roth RA, Blomme EA. Comparison of TNFα to lipopolysaccharide as an inflammagen to characterize the idiosyncratic hepatotoxicity potential of drugs: Trovafloxacin as an example. International Journal of Molecular Sciences. 11: 4697-714. PMID 21151465 DOI: 10.3390/ijms11114697  0.76
2010 Shaw PJ, Ganey PE, Roth RA. Idiosyncratic drug-induced liver injury and the role of inflammatory stress with an emphasis on an animal model of trovafloxacin hepatotoxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 118: 7-18. PMID 20538741 DOI: 10.1093/toxsci/kfq168  0.76
2010 Zou W, Roth RA, Younis HS, Burgoon LD, Ganey PE. Oxidative stress is important in the pathogenesis of liver injury induced by sulindac and lipopolysaccharide cotreatment. Toxicology. 272: 32-8. PMID 20371263 DOI: 10.1016/j.tox.2010.03.015  0.76
2010 Dugan CM, MacDonald AE, Roth RA, Ganey PE. A mouse model of severe halothane hepatitis based on human risk factors. The Journal of Pharmacology and Experimental Therapeutics. 333: 364-72. PMID 20124411 DOI: 10.1124/jpet.109.164541  0.76
2010 Aibo DI, Birmingham NP, Lewandowski R, Maddox JF, Roth RA, Ganey PE, Wagner JG, Harkema JR. Acute exposure to ozone exacerbates acetaminophen-induced liver injury in mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 115: 267-85. PMID 20123758 DOI: 10.1093/toxsci/kfq034  0.76
2010 Roth RA, Ganey PE. Intrinsic versus idiosyncratic drug-induced hepatotoxicity--two villains or one? The Journal of Pharmacology and Experimental Therapeutics. 332: 692-7. PMID 20019161 DOI: 10.1124/jpet.109.162651  0.76
2010 Maddox JF, Amuzie CJ, Li M, Newport SW, Sparkenbaugh E, Cuff CF, Pestka JJ, Cantor GH, Roth RA, Ganey PE. Bacterial- and viral-induced inflammation increases sensitivity to acetaminophen hepatotoxicity. Journal of Toxicology and Environmental Health. Part A. 73: 58-73. PMID 19953420 DOI: 10.1080/15287390903249057  0.76
2009 Deng X, Luyendyk JP, Ganey PE, Roth RA. Inflammatory stress and idiosyncratic hepatotoxicity: hints from animal models. Pharmacological Reviews. 61: 262-82. PMID 19805476 DOI: 10.1124/pr.109.001727  0.76
2009 Zou W, Beggs KM, Sparkenbaugh EM, Jones AD, Younis HS, Roth RA, Ganey PE. Sulindac metabolism and synergy with tumor necrosis factor-alpha in a drug-inflammation interaction model of idiosyncratic liver injury. The Journal of Pharmacology and Experimental Therapeutics. 331: 114-21. PMID 19638570 DOI: 10.1124/jpet.109.156331  0.76
2009 Shaw PJ, Beggs KM, Sparkenbaugh EM, Dugan CM, Ganey PE, Roth RA. Trovafloxacin enhances TNF-induced inflammatory stress and cell death signaling and reduces TNF clearance in a murine model of idiosyncratic hepatotoxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 111: 288-301. PMID 19638433 DOI: 10.1093/toxsci/kfp163  0.76
2009 Shaw PJ, Fullerton AM, Scott MA, Ganey PE, Roth RA. The role of the hemostatic system in murine liver injury induced by coexposure to lipopolysaccharide and trovafloxacin, a drug with idiosyncratic liability. Toxicology and Applied Pharmacology. 236: 293-300. PMID 19367693 DOI: 10.1016/j.taap.2009.01.018  0.76
2009 Shaw PJ, Ganey PE, Roth RA. Trovafloxacin enhances the inflammatory response to a Gram-negative or a Gram-positive bacterial stimulus, resulting in neutrophil-dependent liver injury in mice. The Journal of Pharmacology and Experimental Therapeutics. 330: 72-8. PMID 19351866 DOI: 10.1124/jpet.109.151068  0.76
2009 Zou W, Devi SS, Sparkenbaugh E, Younis HS, Roth RA, Ganey PE. Hepatotoxic interaction of sulindac with lipopolysaccharide: role of the hemostatic system. Toxicological Sciences : An Official Journal of the Society of Toxicology. 108: 184-93. PMID 19074762 DOI: 10.1093/toxsci/kfn259  0.76
2009 Shaw PJ, Ditewig AC, Waring JF, Liguori MJ, Blomme EA, Ganey PE, Roth RA. Coexposure of mice to trovafloxacin and lipopolysaccharide, a model of idiosyncratic hepatotoxicity, results in a unique gene expression profile and interferon gamma-dependent liver injury. Toxicological Sciences : An Official Journal of the Society of Toxicology. 107: 270-80. PMID 18930950 DOI: 10.1093/toxsci/kfn205  0.76
2009 Shaw PJ, Ganey PE, Roth RA. Tumor necrosis factor alpha is a proximal mediator of synergistic hepatotoxicity from trovafloxacin/lipopolysaccharide coexposure. The Journal of Pharmacology and Experimental Therapeutics. 328: 62-8. PMID 18820134 DOI: 10.1124/jpet.108.143792  0.76
2009 Roth RA, Ganey PE. Inflammation and Drug-Induced Liver Injury The Liver: Biology and Pathobiology: Fifth Edition. 773-781. DOI: 10.1002/9780470747919.ch47  0.76
2008 Deng X, Liguori MJ, Sparkenbaugh EM, Waring JF, Blomme EA, Ganey PE, Roth RA. Gene expression profiles in livers from diclofenac-treated rats reveal intestinal bacteria-dependent and -independent pathways associated with liver injury. The Journal of Pharmacology and Experimental Therapeutics. 327: 634-44. PMID 18801949 DOI: 10.1124/jpet.108.140335  0.76
2008 Deng X, Lu J, Lehman-McKeeman LD, Malle E, Crandall DL, Ganey PE, Roth RA. p38 mitogen-activated protein kinase-dependent tumor necrosis factor-alpha-converting enzyme is important for liver injury in hepatotoxic interaction between lipopolysaccharide and ranitidine. The Journal of Pharmacology and Experimental Therapeutics. 326: 144-52. PMID 18390808 DOI: 10.1124/jpet.108.137497  0.76
2007 Shaw PJ, Hopfensperger MJ, Ganey PE, Roth RA. Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha. Toxicological Sciences : An Official Journal of the Society of Toxicology. 100: 259-66. PMID 17709330 DOI: 10.1093/toxsci/kfm218  0.76
2007 Tukov FF, Luyendyk JP, Ganey PE, Roth RA. The role of tumor necrosis factor alpha in lipopolysaccharide/ranitidine-induced inflammatory liver injury. Toxicological Sciences : An Official Journal of the Society of Toxicology. 100: 267-80. PMID 17698507 DOI: 10.1093/toxsci/kfm209  0.76
2007 Ganey PE, Luyendyk JP, Newport SW, Eagle TM, Maddox JF, Mackman N, Roth RA. Role of the coagulation system in acetaminophen-induced hepatotoxicity in mice. Hepatology (Baltimore, Md.). 46: 1177-86. PMID 17654741 DOI: 10.1002/hep.21779  0.76
2007 Deng X, Luyendyk JP, Zou W, Lu J, Malle E, Ganey PE, Roth RA. Neutrophil interaction with the hemostatic system contributes to liver injury in rats cotreated with lipopolysaccharide and ranitidine. The Journal of Pharmacology and Experimental Therapeutics. 322: 852-61. PMID 17505017 DOI: 10.1124/jpet.107.122069  0.76
2007 Bezdecny SA, Karmaus P, Roth RA, Ganey PE. 2,2',4,4'-Tetrachlorobiphenyl upregulates cyclooxygenase-2 in HL-60 cells via p38 mitogen-activated protein kinase and NF-kappaB. Toxicology and Applied Pharmacology. 221: 285-94. PMID 17482227 DOI: 10.1016/j.taap.2007.03.019  0.76
2007 Roberts RA, Ganey PE, Ju C, Kamendulis LM, Rusyn I, Klaunig JE. Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis. Toxicological Sciences : An Official Journal of the Society of Toxicology. 96: 2-15. PMID 17122412 DOI: 10.1093/toxsci/kfl173  0.76
2006 Deng X, Stachlewitz RF, Liguori MJ, Blomme EA, Waring JF, Luyendyk JP, Maddox JF, Ganey PE, Roth RA. Modest inflammation enhances diclofenac hepatotoxicity in rats: role of neutrophils and bacterial translocation. The Journal of Pharmacology and Experimental Therapeutics. 319: 1191-9. PMID 16990511 DOI: 10.1124/jpet.106.110247  0.76
2006 Copple BL, Roth RA, Ganey PE. Anticoagulation and inhibition of nitric oxide synthase influence hepatic hypoxia after monocrotaline exposure. Toxicology. 225: 128-37. PMID 16828949 DOI: 10.1016/j.tox.2006.05.016  0.76
2006 Tukov FF, Maddox JF, Amacher DE, Bobrowski WF, Roth RA, Ganey PE. Modeling inflammation-drug interactions in vitro: a rat Kupffer cell-hepatocyte coculture system. Toxicology in Vitro : An International Journal Published in Association With Bibra. 20: 1488-99. PMID 16782301 DOI: 10.1016/j.tiv.2006.04.005  0.76
2006 Luyendyk JP, Lehman-McKeeman LD, Nelson DM, Bhaskaran VM, Reilly TP, Car BD, Cantor GH, Maddox JF, Ganey PE, Roth RA. Unique gene expression and hepatocellular injury in the lipopolysaccharide-ranitidine drug idiosyncrasy rat model: comparison with famotidine. Toxicological Sciences : An Official Journal of the Society of Toxicology. 90: 569-85. PMID 16415329 DOI: 10.1093/toxsci/kfj103  0.76
2006 Luyendyk JP, Lehman-McKeeman LD, Nelson DM, Bhaskaran VM, Reilly TP, Car BD, Cantor GH, Deng X, Maddox JF, Ganey PE, Roth RA. Coagulation-dependent gene expression and liver injury in rats given lipopolysaccharide with ranitidine but not with famotidine. The Journal of Pharmacology and Experimental Therapeutics. 317: 635-43. PMID 16401727 DOI: 10.1124/jpet.105.096305  0.76
2006 Waring JF, Liguori MJ, Luyendyk JP, Maddox JF, Ganey PE, Stachlewitz RF, North C, Blomme EA, Roth RA. Microarray analysis of lipopolysaccharide potentiation of trovafloxacin-induced liver injury in rats suggests a role for proinflammatory chemokines and neutrophils. The Journal of Pharmacology and Experimental Therapeutics. 316: 1080-7. PMID 16299187 DOI: 10.1124/jpet.105.096347  0.76
2006 Maddox JF, Luyendyk JP, Cosma GN, Breau AP, Bible RH, Harrigan GG, Goodacre R, Ganey PE, Cantor GH, Cockerell GL, Roth RA. Metabonomic evaluation of idiosyncrasy-like liver injury in rats cotreated with ranitidine and lipopolysaccharide. Toxicology and Applied Pharmacology. 212: 35-44. PMID 16051291 DOI: 10.1016/j.taap.2005.06.021  0.76
2005 Luyendyk JP, Shaw PJ, Green CD, Maddox JF, Ganey PE, Roth RA. Coagulation-mediated hypoxia and neutrophil-dependent hepatic injury in rats given lipopolysaccharide and ranitidine. The Journal of Pharmacology and Experimental Therapeutics. 314: 1023-31. PMID 15933155 DOI: 10.1124/jpet.105.087981  0.76
2005 Roth RA, Ganey PE, Uetrecht J, Shenton J, Chen J. Letter to the Editor (multiple letters) Chemico-Biological Interactions. 152: 165-168. PMID 15840389 DOI: 10.1016/j.cbi.2005.02.001  0.76
2005 Luster-Teasley SL, Ganey PE, DiOrio M, Ward JS, Maleczka RE, Trosko JE, Masten SJ. Effect of byproducts from the ozonation of pyrene: biphenyl-2,2',6,6'-tetracarbaldehyde and biphenyl-2,2',6,6'-tetracarboxylic acid on gap junction intercellular communication and neutrophil function. Environmental Toxicology and Chemistry / Setac. 24: 733-40. PMID 15786580 DOI: 10.1897/04-679.1  0.76
2005 Ganey PE, Boyd SA. An approach to evaluation of the effect of bioremediation on biological activity of environmental contaminants: dechlorination of polychlorinated biphenyls. Environmental Health Perspectives. 113: 180-5. PMID 15687055 DOI: 10.1289/ehp.6935  0.76
2005 Bezdecny SA, Roth RA, Ganey PE. Effects of 2,2',4,4'-tetrachlorobiphenyl on granulocytic HL-60 cell function and expression of cyclooxygenase-2. Toxicological Sciences : An Official Journal of the Society of Toxicology. 84: 328-34. PMID 15673847 DOI: 10.1093/toxsci/kfi093  0.76
2004 Luyendyk JP, Maddox JF, Green CD, Ganey PE, Roth RA. Role of hepatic fibrin in idiosyncrasy-like liver injury from lipopolysaccharide-ranitidine coexposure in rats. Hepatology (Baltimore, Md.). 40: 1342-51. PMID 15565632 DOI: 10.1002/hep.20492  0.76
2004 Ganey PE, Luyendyk JP, Maddox JF, Roth RA. Adverse hepatic drug reactions: inflammatory episodes as consequence and contributor. Chemico-Biological Interactions. 150: 35-51. PMID 15522260 DOI: 10.1016/j.cbi.2004.09.002  0.76
2004 Kinser S, Sneed R, Roth R, Ganey P. Neutrophils contribute to endotoxin enhancement of allyl alcohol hepatotoxicity. Journal of Toxicology and Environmental Health. Part A. 67: 911-28. PMID 15205035 DOI: 10.1080/15287390490443704  0.76
2004 Luyendyk JP, Mattes WB, Burgoon LD, Zacharewski TR, Maddox JF, Cosma GN, Ganey PE, Roth RA. Gene expression analysis points to hemostasis in livers of rats cotreated with lipopolysaccharide and ranitidine. Toxicological Sciences : An Official Journal of the Society of Toxicology. 80: 203-13. PMID 15084757 DOI: 10.1093/toxsci/kfh146  0.76
2004 Harrigan GG, LaPlante RH, Cosma GN, Cockerell G, Goodacre R, Maddox JF, Luyendyk JP, Ganey PE, Roth RA. Application of high-throughput Fourier-transform infrared spectroscopy in toxicology studies: contribution to a study on the development of an animal model for idiosyncratic toxicity. Toxicology Letters. 146: 197-205. PMID 14687757 DOI: 10.1016/j.toxlet.2003.09.011  0.76
2004 Maddox JF, Domzalski AC, Roth RA, Ganey PE. 15-deoxy prostaglandin J2 enhances allyl alcohol-induced toxicity in rat hepatocytes. Toxicological Sciences : An Official Journal of the Society of Toxicology. 77: 290-8. PMID 14657518 DOI: 10.1093/toxsci/kfh028  0.76
2004 Copple BL, Rondelli CM, Maddox JF, Hoglen NC, Ganey PE, Roth RA. Modes of cell death in rat liver after monocrotaline exposure. Toxicological Sciences : An Official Journal of the Society of Toxicology. 77: 172-82. PMID 14600277 DOI: 10.1093/toxsci/kfh011  0.76
2003 Hanumegowda UM, Copple BL, Shibuya M, Malle E, Ganey PE, Roth RA. Basement membrane and matrix metalloproteinases in monocrotaline-induced liver injury. Toxicological Sciences : An Official Journal of the Society of Toxicology. 76: 237-46. PMID 12970574 DOI: 10.1093/toxsci/kfg222  0.76
2003 Roth RA, Luyendyk JP, Maddox JF, Ganey PE. Inflammation and drug idiosyncrasy--is there a connection? The Journal of Pharmacology and Experimental Therapeutics. 307: 1-8. PMID 12954806 DOI: 10.1124/jpet.102.041624  0.76
2003 Copple BL, Ganey PE, Roth RA. Liver inflammation during monocrotaline hepatotoxicity. Toxicology. 190: 155-69. PMID 12927372 DOI: 10.1016/S0300-483X(03)00164-1  0.76
2003 Luyendyk JP, Maddox JF, Cosma GN, Ganey PE, Cockerell GL, Roth RA. Ranitidine treatment during a modest inflammatory response precipitates idiosyncrasy-like liver injury in rats. The Journal of Pharmacology and Experimental Therapeutics. 307: 9-16. PMID 12893837 DOI: 10.1124/jpet.103.054288  0.76
2003 Yee SB, Harkema JR, Ganey PE, Roth RA. The coagulation system contributes to synergistic liver injury from exposure to monocrotaline and bacterial lipopolysaccharide. Toxicological Sciences : An Official Journal of the Society of Toxicology. 74: 457-69. PMID 12773766 DOI: 10.1093/toxsci/kfg129  0.76
2003 Maddox JF, Roth RA, Ganey PE. Allyl alcohol activation of protein kinase C delta leads to cytotoxicity of rat hepatocytes. Chemical Research in Toxicology. 16: 609-15. PMID 12755590 DOI: 10.1021/tx025655n  0.76
2003 Yee SB, Hanumegowda UM, Copple BL, Shibuya M, Ganey PE, Roth RA. Endothelial cell injury and coagulation system activation during synergistic hepatotoxicity from monocrotaline and bacterial lipopolysaccharide coexposure. Toxicological Sciences : An Official Journal of the Society of Toxicology. 74: 203-14. PMID 12730616 DOI: 10.1093/toxsci/kfg106  0.76
2003 Copple BL, Moulin F, Hanumegowda UM, Ganey PE, Roth RA. Thrombin and protease-activated receptor-1 agonists promote lipopolysaccharide-induced hepatocellular injury in perfused livers. The Journal of Pharmacology and Experimental Therapeutics. 305: 417-25. PMID 12606620 DOI: 10.1124/jpet.102.046391  0.76
2003 Luyendyk JP, Copple BL, Barton CC, Ganey PE, Roth RA. Augmentation of aflatoxin B1 hepatotoxicity by endotoxin: involvement of endothelium and the coagulation system. Toxicological Sciences : An Official Journal of the Society of Toxicology. 72: 171-81. PMID 12604847 DOI: 10.1093/toxsci/kfg007  0.76
2003 Yee SB, Hanumegowda UM, Hotchkiss JA, Ganey PE, Roth RA. Role of neutrophils in the synergistic liver injury from monocrotaline and bacterial lipopolysaccharide exposure. Toxicological Sciences : An Official Journal of the Society of Toxicology. 72: 43-56. PMID 12604833 DOI: 10.1093/toxsci/kfg019  0.76
2003 Yee SB, Ganey PE, Roth RA. The role of Kupffer cells and TNF-alpha in monocrotaline and bacterial lipopolysaccharide-induced liver injury. Toxicological Sciences : An Official Journal of the Society of Toxicology. 71: 124-32. PMID 12520082 DOI: 10.1093/toxsci/71.1.124  0.76
2002 Kinser S, Copple BL, Roth RA, Ganey PE. Enhancement of allyl alcohol hepatotoxicity by endotoxin requires extrahepatic factors. Toxicological Sciences : An Official Journal of the Society of Toxicology. 69: 470-81. PMID 12377996 DOI: 10.1093/toxsci/69.2.470  0.76
2002 Yee SB, Copple BL, Ganey PE, Roth RA. The temporal relationship between bacterial lipopolysaccharide and monocrotaline exposures influences toxicity: shift in response from hepatotoxicity to nitric oxide-dependent lethality. Journal of Toxicology and Environmental Health. Part A. 65: 961-76. PMID 12133231 DOI: 10.1080/00984100290071261  0.76
2002 Luyendyk JP, Shores KC, Ganey PE, Roth RA. Bacterial lipopolysaccharide exposure alters aflatoxin B(1) hepatotoxicity: benchmark dose analysis for markers of liver injury. Toxicological Sciences : An Official Journal of the Society of Toxicology. 68: 220-5. PMID 12075124 DOI: 10.1093/toxsci/68.1.220  0.76
2002 Copple BL, Woolley B, Banes A, Ganey PE, Roth RA. Anticoagulants prevent monocrotaline-induced hepatic parenchymal cell injury but not endothelial cell injury in the rat. Toxicology and Applied Pharmacology. 180: 186-96. PMID 12009858 DOI: 10.1006/taap.2002.9394  0.76
2002 Olivero J, Bezdecny SA, Ganey PE. A molecular motif required for the activation of rat neutrophil phospholipase A(2) by organochlorine compounds. Chemical Research in Toxicology. 15: 153-9. PMID 11849040 DOI: 10.1021/tx0155449  0.76
2002 Copple BL, Banes A, Ganey PE, Roth RA. Endothelial cell injury and fibrin deposition in rat liver after monocrotaline exposure. Toxicological Sciences : An Official Journal of the Society of Toxicology. 65: 309-18. PMID 11812935 DOI: 10.1093/toxsci/65.2.309  0.76
2002 Buchweitz JP, Ganey PE, Bursian SJ, Roth RA. Underlying endotoxemia augments toxic responses to chlorpromazine: is there a relationship to drug idiosyncrasy? The Journal of Pharmacology and Experimental Therapeutics. 300: 460-7. PMID 11805205 DOI: 10.1124/jpet.300.2.460  0.76
2001 Ganey PE, Roth RA. Concurrent inflammation as a determinant of susceptibility to toxicity from xenobiotic agents Toxicology. 169: 195-208. PMID 11718960 DOI: 10.1016/S0300-483X(01)00523-6  0.76
2001 Moulin F, Copple BL, Ganey PE, Roth RA. Hepatic and extrahepatic factors critical for liver injury during lipopolysaccharide exposure American Journal of Physiology - Gastrointestinal and Liver Physiology. 281. PMID 11705747  0.76
2001 Olivero J, Ganey PE. Participation of Ca2+/calmodulin during activation of rat neutrophils by polychlorinated biphenyls Biochemical Pharmacology. 62: 1125-1132. PMID 11597581 DOI: 10.1016/S0006-2952(01)00768-7  0.76
2001 Ganey PE, Barton YW, Kinser S, Sneed RA, Barton CC, Roth RA. Involvement of cyclooxygenase-2 in the potentiation of allyl alcohol-induced liver injury by bacterial lipopolysaccharide. Toxicology and Applied Pharmacology. 174: 113-21. PMID 11446826 DOI: 10.1006/taap.2001.9183  0.76
2001 Barton CC, Barton EX, Ganey PE, Kunkel SL, Roth RA. Bacterial lipopolysaccharide enhances aflatoxin B1 hepatotoxicity in rats by a mechanism that depends on tumor necrosis factor α Hepatology. 33: 66-73. PMID 11124822 DOI: 10.1053/jhep.2001.20643  0.76
2000 Barton CC, Ganey PE, Roth RA. Lipopolysaccharide augments aflatoxin B1-induced liver injury through neutrophil-dependent and -independent mechanisms Toxicological Sciences. 58: 208-215. PMID 11053557  0.76
2000 Yee SB, Kinser S, Hill DA, Barton CC, Hotchkiss JA, Harkema JR, Ganey PE, Roth RA. Synergistic hepatotoxicity from coexposure to bacterial endotoxin and the pyrrolizidine alkaloid monocrotaline. Toxicology and Applied Pharmacology. 166: 173-85. PMID 10906281 DOI: 10.1006/taap.2000.8968  0.76
2000 Sneed RA, Buchweitz JP, Jean PA, Ganey PE. Pentoxifylline attenuates bacterial lipopolysaccharide-induced enhancement of allyl alcohol hepatotoxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 56: 203-10. PMID 10869469  0.76
2000 Barton CC, Hill DA, Yee SB, Barton EX, Ganey PE, Roth RA. Bacterial lipopolysaccharide exposure augments aflatoxin B1-induced liver injury Toxicological Sciences. 55: 444-452. PMID 10828277  0.76
2000 Olivero J, Ganey PE. Role of protein phosphorylation in activation of phospholipase A2 by the polychlorinated biphenyl mixture Aroclor 1242 Toxicology and Applied Pharmacology. 163: 9-16. PMID 10662600 DOI: 10.1006/taap.1999.8827  0.76
2000 Tithof PK, Olivero J, Ruehle K, Ganey PE. Activation of neutrophil calcium-dependent and -independent phospholipases A2 by organochlorine compounds Toxicological Sciences. 53: 40-47. PMID 10653519  0.76
2000 Ganey PE, Quensen JF, Mousa MA, Boyd SA, Wagner MA, Fischer LJ. Biological activity associated with noncoplanar polychlorinated biphenyls after microbial dechlorination of Aroclor 1242® and aroclor 1254® Environmental Toxicology and Chemistry. 19: 1311-1316.  0.76
1998 Brown AP, Olivero-Verbel J, Holdan WL, Ganey PE. Neutrophil activation by polychlorinated biphenyls: Structure-activity relationship Toxicological Sciences. 46: 308-316. PMID 10048134 DOI: 10.1006/toxs.1998.2551  0.76
1998 Mousa MA, Ganey PE, Quensen JF, Madhukar BV, Chou K, Giesy JP, Fischer LJ, Boyd SA. Altered biologic activities of commercial polychlorinated biphenyl mixtures after microbial reductive dechlorination. Environmental Health Perspectives. 106: 1409-18. PMID 9860899  0.76
1998 Olivero-Verbel J, Ganey PE. Effect of three polychlorinated biphenyls on f-met-leu-phe-induced degranulation in rat neutrophils Toxicology Letters. 98: 195-202. PMID 9788588 DOI: 10.1016/S0378-4274(98)00117-9  0.76
1998 Tithof PK, Peters-Golden M, Ganey PE. Distinct phospholipases A2 regulate the release of arachidonic acid for eicosanoid production and superoxide anion generation in neutrophils Journal of Immunology. 160: 953-960. PMID 9551934  0.76
1998 Fischer LJ, Seegal RF, Ganey PE, Pessah IN, Kodavanti PR. Symposium overview: toxicity of non-coplanar PCBs. Toxicological Sciences : An Official Journal of the Society of Toxicology. 41: 49-61. PMID 9520341 DOI: 10.1006/toxs.1997.2386  0.76
1998 Narayanan PK, Carter WO, Ganey PE, Roth RA, Voytik-Harbin SL, Robinson JP. Impairment of human neutrophil oxidative burst by polychlorinated biphenyls: Inhibition of superoxide dismutase activity Journal of Leukocyte Biology. 63: 216-224. PMID 9468280  0.76
1997 Molnar RG, Wang P, Ayala A, Ganey PE, Roth RA, Chaudry IH. The role of neutrophils in producing hepatocellular dysfunction during the hyperdynamic stage of sepsis in rats Journal of Surgical Research. 73: 117-122. PMID 9441804 DOI: 10.1006/jsre.1997.5216  0.76
1997 Roth RA, Harkema JR, Pestka JP, Ganey PE. Is exposure to bacterial endotoxin a determinant of susceptibility to intoxication from xenobiotic agents? Toxicology and Applied Pharmacology. 147: 300-311. PMID 9439725 DOI: 10.1006/taap.1997.8301  0.76
1997 Tithof PK, Watts S, Ganey PE. Protein tyrosine kinase involvement in the production of superoxide anion by neutrophils exposed to aroclor 1242, a mixture of polychlorinated biphenyls Biochemical Pharmacology. 53: 1833-1842. PMID 9256158 DOI: 10.1016/S0006-2952(97)82447-1  0.76
1997 Srinivasan R, Buchweitz JP, Ganey PE. Alteration by flutamide of neutrophil response to stimulation: Implications for tissue injury Biochemical Pharmacology. 53: 1179-1185. PMID 9175723 DOI: 10.1016/S0006-2952(97)00099-3  0.76
1997 Sneed RA, Grimes SD, Schultze AE, Brown AP, Ganey PE. Bacterial endotoxin enhances the hepatotoxicity of allyl alcohol. Toxicology and Applied Pharmacology. 144: 77-87. PMID 9169072 DOI: 10.1006/taap.1997.8115  0.76
1997 Brown AP, Harkema JR, Eric Schultze A, Roth RA, Ganey PE. Gadolinium chloride pretreatment protects against hepatic injury but predisposes the lungs to alveolitis after lipopolysaccharide administration Shock. 7: 186-192. PMID 9068084  0.76
1996 Moulin F, Pearson JM, Schultze AE, Scott MA, Schwartz KA, Davis JM, Ganey PE, Roth RA. Thrombin is a distal mediator of lipopolysaccharide-induced liver injury in the rat Journal of Surgical Research. 65: 149-158. PMID 8903462 DOI: 10.1006/jsre.1996.0358  0.76
1996 Tithof PK, Schiamberg E, Peters-Golden M, Ganey PE. Phospholipase A2 is involved in the mechanism of activation of neutrophils by polychlorinated biphenyls Environmental Health Perspectives. 104: 52-58. PMID 8834862  0.76
1996 Jaeschke H, Smith CW, Clemens MG, Ganey PE, Roth RA. Mechanisms of inflammatory liver injury: Adhesion molecules and cytotoxicity of neutrophils Toxicology and Applied Pharmacology. 139: 213-226. PMID 8806837 DOI: 10.1006/taap.1996.0160  0.76
1996 Pearson JM, Brown AP, Schultze AE, Ganey PE, Roth RA. Gadolinium chloride treatment attenuates hepatic platelet accumulation after lipopolysaccharide administration Shock. 5: 408-415. PMID 8799952  0.76
1996 Brown AP, Schultze AE, Holdan WL, Buchweitz JP, Roth RA, Ganey PE. Lipopolysaccharide-induced hepatic injury is enhanced by polychlorinated biphenyls Environmental Health Perspectives. 104: 634-640. PMID 8793352  0.76
1996 Ho JS, Buchweitz JP, Roth RA, Ganey PE. Identification of factors from rat neutrophils responsible for cytotoxicity to isolated hepatocytes Journal of Leukocyte Biology. 59: 716-724. PMID 8656057  0.76
1995 Tithof PK, Contreras ML, Ganey PE. Aroclor 1242 Stimulates the Production of Inositol Phosphates in Polymorphonuclear Neutrophils Toxicology and Applied Pharmacology. 131: 136-143. PMID 7878669 DOI: 10.1006/taap.1995.1055  0.76
1995 Ganey PE, Schultze AE. Depletion of neutrophils and modulation of Kupffer cell function in allyl alcohol-induced hepatotoxicity Toxicology. 99: 99-106. PMID 7762005 DOI: 10.1016/0300-483X(94)03005-M  0.76
1995 Brown AP, Ganey PE. Neutrophil Degranulation and Superoxide Production Induced by Polychlorinated Biphenyls Are Calcium Dependent Toxicology and Applied Pharmacology. 131: 198-205. PMID 7716762 DOI: 10.1006/taap.1995.1062  0.76
1994 Ganey PE, Bailie MB, VanCise S, Colligan ME, Madhukar BV, Robinson JP, Roth RA. Activated neutrophils from rat injured isolated hepatocytes Laboratory Investigation. 70: 53-60. PMID 8302018  0.76
1993 Ganey PE, Sirois JE, Denison M, Robinson JP, Roth RA. Neutrophil function after exposure to polychlorinated biphenyls in vitro Environmental Health Perspectives. 101: 430-434. PMID 8119254  0.76
1991 Ganey PE, Carter LS, Mueller RA, Thurman RG. Doxorubicin toxicity in perfused rat heart. Decreased cell death at low oxygen tension Circulation Research. 68: 1610-1613. PMID 2036713  0.76
1991 Ganey PE, Thurman RG. Ethanol Potentiates Doxorubicin-induced Inhibition of Cell Survival in Cultured Chinese Hamster Ovary Cells Cancer Research. 51: 2036-2040. PMID 2009522  0.76
1991 Ganey PE, Keller B, Lichtman SN, Lemasters JJ, Thurman RG. A new method to monitor Kupffer cell phagocytosis continuously in perfused rat liver Hepatology. 13: 567-574. PMID 1999326  0.76
1991 Thurman RG, Ganey PE, Yi-ren W. Role of oxygen in regulation of metabolism of substituted organic amines in perfused mouse liver Progress in Pharmacology and Clinical Pharmacology. 8: 177-183.  0.76
1990 Reindel JF, Ganey PE, Wagner JG, Slocombe RF, Roth RA. Development of morphologic, hemodynamic, and biochemical changes in lungs of rats given monocrotaline pyrrole Toxicology and Applied Pharmacology. 106: 179-200. PMID 2256110 DOI: 10.1016/0041-008X(90)90239-Q  0.76
1990 Ganey PE, Takei Y, Kauffman FC, Thurman RG. Ethanol potentiates oxygen uptake and toxicity due to menadione bisulfite in perfused rat liver Molecular Pharmacology. 38: 959-964. PMID 2250668  0.76
1989 Badr MZ, Ganey PE, Yoshihara H, Kauffman FC, Thurman RG. Hepatotoxicity of menadione predominates in oxygen-rich zones of the liver lobule Journal of Pharmacology and Experimental Therapeutics. 248: 1317-1322. PMID 2703976  0.76
1988 Ganey PE, Kauffman FC, Thurman RG. Oxygen-dependent hepatotoxicity due to doxorubicin: Role of reducing equivalent supply in perfused rat liver Molecular Pharmacology. 34: 695-701. PMID 3193959  0.76
1988 Ganey PE, Sprugel KH, White SM, Wagner JG, Roth RA. Pulmonary hypertension due to monocrotaline pyrrole is reduced by moderate thrombocytopenia American Journal of Physiology - Heart and Circulatory Physiology. 255. PMID 3189578  0.76
1988 Roth RA, Ganey PE. Platelets and the puzzles of pulmonary pyrrolizidine poisoning Toxicology and Applied Pharmacology. 93: 463-471. PMID 3130680 DOI: 10.1016/0041-008X(88)90050-6  0.76
1987 Ganey PE, Roth RA. Elevated serum copper concentration in monocrotaline pyrrole treated rats with pulmonary hypertension Biochemical Pharmacology. 36: 3535-3537. PMID 3675611 DOI: 10.1016/0006-2952(87)90339-X  0.76
1987 Ganey PE, Roth RA. 5-Hydroxytryptamine and thromboxane in platelets from rats treated with monocrotaline pyrrole Toxicology and Applied Pharmacology. 88: 157-164. PMID 3564035 DOI: 10.1016/0041-008X(87)90001-9  0.76
1987 Ganey PE, Roth RA. 6-keto prostaglandin f and thromboxane b2 in isolated, buffer-perfused lungs from monocrotaline pyrrole-treated rats Experimental Lung Research. 12: 195-206. PMID 3107969 DOI: 10.3109/01902148709064300  0.76
1987 Ganey PE, Roth RA. Thromboxane does not mediate pulmonary vascular response to monocrotaline pyrrole American Journal of Physiology - Heart and Circulatory Physiology. 252. PMID 2952022  0.76
1987 Roth RA, Ganey PE. Arachidonic acid metabolites and the mechanisms of monocrotaline pneumotoxicity American Review of Respiratory Disease. 136: 762-765. PMID 2820283  0.76
1986 Ganey PE, Sprugel KH, Hadley KB, Roth RA. Monocrotaline pyrrole-induced cardiopulmonary toxicity is not altered by metergoline or ketanserin Journal of Pharmacology and Experimental Therapeutics. 237: 226-231. PMID 2937908  0.76
1985 Ganey PE, Fink GD, Roth RA. The effect of dietary restriction and altered sodium intake on the cardiopulmonary toxicity of monocrotaline pyrrole Toxicology and Applied Pharmacology. 78: 55-62. PMID 2930913 DOI: 10.1016/0041-008X(85)90304-7  0.76
1985 Ganey PE, Roth RA. Thromboxane B2 release in platelet-rich plasma from monocrotaline pyrrole-treated rats Federation Proceedings. 44.  0.76
1984 Ganey PE, Roth RA. Release of 6-keto-prostaglandin F(1α) and thromboxane B2 from isolated perfused lungs of monocrotaline pyrrole-treated rats Federation Proceedings. 43.  0.76
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