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Kwang H. Ahn, Ph.D. - Publications

Affiliations: 
2009 University of Connecticut, Storrs, CT, United States 
Area:
Biochemistry
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23 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Tahtouh T, Durieu E, Villiers B, Bruyère C, Nguyen TL, Fant X, Ahn KH, Khurana L, Deau E, Lindberg MF, Sévère E, Miege F, Roche D, Limanton E, L'Helgoual'ch JM, et al. Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors. Journal of Medicinal Chemistry. PMID 34928152 DOI: 10.1021/acs.jmedchem.1c01141  0.477
2016 Qiao CJ, Ali HI, Ahn KH, Kolluru S, Kendall DA, Lu D. Synthesis and biological evaluation of indole-2-carboxamides bearing photoactivatable functionalities as novel allosteric modulators for the cannabinoid CB1 receptor. European Journal of Medicinal Chemistry. 121: 517-529. PMID 27318976 DOI: 10.1016/J.Ejmech.2016.05.044  0.625
2016 Delgado-Peraza F, Ahn K, Nogueras-Ortiz C, Mungrue I, Mackie KP, Kendall DA, Yudowski G. Mechanisms of biased beta-arrestin mediated signaling downstream from the cannabinoid 1 receptor. Molecular Pharmacology. PMID 27009233 DOI: 10.1124/Mol.115.103176  0.608
2015 Scott C, Ahn KH, Graf ST, Goddard Iii WA, Kendall DA, Abrol R. Computational Prediction and Biochemical Analyses of New Inverse Agonists for the CB1 Receptor. Journal of Chemical Information and Modeling. PMID 26633590 DOI: 10.1021/Acs.Jcim.5B00581  0.702
2014 Flores-Otero J, Ahn KH, Delgado-Peraza F, Mackie K, Kendall DA, Yudowski GA. Ligand-specific endocytic dwell times control functional selectivity of the cannabinoid receptor 1. Nature Communications. 5: 4589. PMID 25081814 DOI: 10.1038/Ncomms5589  0.674
2014 Khurana L, Ali HI, Olszewska T, Ahn KH, Damaraju A, Kendall DA, Lu D. Optimization of chemical functionalities of indole-2-carboxamides to improve allosteric parameters for the cannabinoid receptor 1 (CB1). Journal of Medicinal Chemistry. 57: 3040-52. PMID 24635495 DOI: 10.1021/Jm5000112  0.691
2013 Shim JY, Ahn KH, Kendall DA. Molecular basis of cannabinoid CB1 receptor coupling to the G protein heterotrimer Gαiβγ: identification of key CB1 contacts with the C-terminal helix α5 of Gαi. The Journal of Biological Chemistry. 288: 32449-65. PMID 24092756 DOI: 10.1074/Jbc.M113.489153  0.726
2013 Mahmoud MM, Ali HI, Ahn KH, Damaraju A, Samala S, Pulipati VK, Kolluru S, Kendall DA, Lu D. Structure-activity relationship study of indole-2-carboxamides identifies a potent allosteric modulator for the cannabinoid receptor 1 (CB1). Journal of Medicinal Chemistry. 56: 7965-75. PMID 24053617 DOI: 10.1021/Jm4009828  0.716
2013 Ahn KH, Mahmoud MM, Shim JY, Kendall DA. Distinct roles of β-arrestin 1 and β-arrestin 2 in ORG27569-induced biased signaling and internalization of the cannabinoid receptor 1 (CB1). The Journal of Biological Chemistry. 288: 9790-800. PMID 23449980 DOI: 10.1074/Jbc.M112.438804  0.726
2013 Ahn KH, Scott CE, Abrol R, Goddard WA, Kendall DA. Computationally-predicted CB1 cannabinoid receptor mutants show distinct patterns of salt-bridges that correlate with their level of constitutive activity reflected in G protein coupling levels, thermal stability, and ligand binding. Proteins. 81: 1304-17. PMID 23408552 DOI: 10.1002/Prot.24264  0.719
2013 Ahn KH, Mahmoud MM, Samala S, Lu D, Kendall DA. Profiling two indole-2-carboxamides for allosteric modulation of the CB1 receptor. Journal of Neurochemistry. 124: 584-9. PMID 23205875 DOI: 10.1111/Jnc.12115  0.719
2013 Scott CE, Abrol R, Ahn KH, Kendall DA, Goddard WA. Molecular basis for dramatic changes in cannabinoid CB1 G protein-coupled receptor activation upon single and double point mutations. Protein Science : a Publication of the Protein Society. 22: 101-13. PMID 23184890 DOI: 10.1002/Pro.2192  0.654
2012 Ahn KH, Mahmoud MM, Kendall DA. Allosteric modulator ORG27569 induces CB1 cannabinoid receptor high affinity agonist binding state, receptor internalization, and Gi protein-independent ERK1/2 kinase activation. The Journal of Biological Chemistry. 287: 12070-82. PMID 22343625 DOI: 10.1074/Jbc.M111.316463  0.773
2011 Stadel R, Ahn KH, Kendall DA. The cannabinoid type-1 receptor carboxyl-terminus, more than just a tail. Journal of Neurochemistry. 117: 1-18. PMID 21244428 DOI: 10.1111/J.1471-4159.2011.07186.X  0.713
2011 Oh DJ, Kim KM, Ahn KH. Nanoparticle-based indicator-displacement assay for pyrophosphate Chemistry - An Asian Journal. 6: 2034-2039. DOI: 10.1002/Asia.201100149  0.407
2010 Bertalovitz AC, Ahn KH, Kendall DA. Ligand Binding Sensitivity of the Extracellular Loop Two of the Cannabinoid Receptor 1. Drug Development Research. 71: 404-411. PMID 21170298 DOI: 10.1002/Ddr.20388  0.783
2010 Ahn KH, Nishiyama A, Mierke DF, Kendall DA. Hydrophobic residues in helix 8 of cannabinoid receptor 1 are critical for structural and functional properties. Biochemistry. 49: 502-11. PMID 20025243 DOI: 10.1021/Bi901619R  0.723
2009 Ahn KH, Bertalovitz AC, Mierke DF, Kendall DA. Dual role of the second extracellular loop of the cannabinoid receptor 1: ligand binding and receptor localization. Molecular Pharmacology. 76: 833-42. PMID 19643997 DOI: 10.1124/Mol.109.057356  0.795
2009 Ahn KH, Pellegrini M, Tsomaia N, Yatawara AK, Kendall DA, Mierke DF. Structural analysis of the human cannabinoid receptor one carboxyl-terminus identifies two amphipathic helices. Biopolymers. 91: 565-73. PMID 19274719 DOI: 10.1002/Bip.21179  0.651
2006 D'Antona AM, Ahn KH, Wang L, Mierke DF, Lucas-Lenard J, Kendall DA. A cannabinoid receptor 1 mutation proximal to the DRY motif results in constitutive activity and reveals intramolecular interactions involved in receptor activation. Brain Research. 1108: 1-11. PMID 16879811 DOI: 10.1016/J.Brainres.2006.05.042  0.793
2006 D'Antona AM, Ahn KH, Kendall DA. Mutations of CB1 T210 produce active and inactive receptor forms: correlations with ligand affinity, receptor stability, and cellular localization. Biochemistry. 45: 5606-17. PMID 16634642 DOI: 10.1021/Bi060067K  0.804
2006 Kim J, Raman B, Ahn KH. Artificial receptors that provides a preorganized hydrophobic environment: a biomimetic approach to dopamine recognition in water. The Journal of Organic Chemistry. 71: 38-45. PMID 16388615 DOI: 10.1021/Jo051630S  0.492
2000 Kim SG, Ahn KH. Novel arificial receptors for alkylammonium ions with remarkable selectivity and affinity Chemistry - a European Journal. 6: 3399-3403.  0.437
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