Stephen L. Helfand - Publications

Molecular Biology, Cell Biology and Biochemistry Brown University, Providence, RI 

47 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Taylor J, Wood J, Chang C, Finn M, Liu J, Kim D, Helfand S. REGULATION OF LIFESPAN BY DSIRT6 IN DROSOPHILA MELANOGASTER Innovation in Aging. 2: 90-91. DOI: 10.1093/GERONI/IGY023.344  0.315
2016 Jones BC, Wood JG, Chang C, Tam AD, Franklin MJ, Siegel ER, Helfand SL. A somatic piRNA pathway in the Drosophila fat body ensures metabolic homeostasis and normal lifespan. Nature Communications. 7: 13856. PMID 28000665 DOI: 10.1038/ncomms13856  0.306
2016 Wood JG, Jones BC, Jiang N, Chang C, Hosier S, Wickremesinghe P, Garcia M, Hartnett DA, Burhenn L, Neretti N, Helfand SL. Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. PMID 27621458 DOI: 10.1073/Pnas.1604621113  0.368
2015 Pu M, Ni Z, Wang M, Wang X, Wood JG, Helfand SL, Yu H, Lee SS. Trimethylation of Lys36 on H3 restricts gene expression change during aging and impacts life span. Genes & Development. 29: 718-31. PMID 25838541 DOI: 10.1101/Gad.254144.114  0.352
2014 Ding F, Gil MP, Franklin M, Ferreira J, Tatar M, Helfand SL, Neretti N. Transcriptional response to dietary restriction in Drosophila melanogaster. Journal of Insect Physiology. 69: 101-6. PMID 24819200 DOI: 10.1016/J.Jinsphys.2014.05.002  0.349
2014 Birkenfeld AL, Samuel VT, Shulman GI, De Cabo R, Reenan RA, Zhu C, Helfand S. I'm not Dead Yet: Flies and Mice Biophysical Journal. 106: 12a. DOI: 10.1016/J.Bpj.2013.11.118  0.322
2013 Wood JG, Helfand SL. Chromatin structure and transposable elements in organismal aging. Frontiers in Genetics. 4: 274. PMID 24363663 DOI: 10.3389/fgene.2013.00274  0.31
2013 Wood JG, Whitaker R, Helfand SL. Genetic and biochemical tools for investigating sirtuin function in Drosophila melanogaster. Methods in Molecular Biology (Clifton, N.J.). 1077: 57-67. PMID 24014399 DOI: 10.1007/978-1-62703-637-5_4  0.33
2013 Rogina B, Helfand SL. Indy mutations and Drosophila longevity. Frontiers in Genetics. 4: 47. PMID 23580130 DOI: 10.3389/Fgene.2013.00047  0.334
2012 Chamseddin KH, Khan SQ, Nguyen ML, Antosh M, Morris SN, Kolli S, Neretti N, Helfand SL, Bauer JH. takeout-dependent longevity is associated with altered Juvenile Hormone signaling. Mechanisms of Ageing and Development. 133: 637-46. PMID 22940452 DOI: 10.1016/J.Mad.2012.08.004  0.341
2011 Antosh M, Whitaker R, Kroll A, Hosier S, Chang C, Bauer J, Cooper L, Neretti N, Helfand SL. Comparative transcriptional pathway bioinformatic analysis of dietary restriction, Sir2, p53 and resveratrol life span extension in Drosophila. Cell Cycle (Georgetown, Tex.). 10: 904-11. PMID 21325893 DOI: 10.4161/Cc.10.6.14912  0.343
2010 Wood JG, Hillenmeyer S, Lawrence C, Chang C, Hosier S, Lightfoot W, Mukherjee E, Jiang N, Schorl C, Brodsky AS, Neretti N, Helfand SL. Chromatin remodeling in the aging genome of Drosophila. Aging Cell. 9: 971-8. PMID 20961390 DOI: 10.1111/J.1474-9726.2010.00624.X  0.312
2010 Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R, Deng C, Dimmeler S, Gius D, Guarente LP, Helfand SL, Imai S, Itoh H, Kadowaki T, Koya D, et al. Dietary restriction: standing up for sirtuins. Science (New York, N.Y.). 329: 1012-3; author reply. PMID 20798296 DOI: 10.1126/Science.329.5995.1012  0.302
2010 Bauer JH, Chang C, Bae G, Morris SN, Helfand SL. Dominant-negative Dmp53 extends life span through the dTOR pathway in D. melanogaster. Mechanisms of Ageing and Development. 131: 193-201. PMID 20117129 DOI: 10.1016/j.mad.2010.01.007  0.308
2009 Bauer JH, Helfand SL. Sir2 and longevity: the p53 connection. Cell Cycle (Georgetown, Tex.). 8: 1821. PMID 19471127 DOI: 10.4161/Cc.8.12.9010  0.322
2009 Neretti N, Wang PY, Brodsky AS, Nyguyen HH, White KP, Rogina B, Helfand SL. Long-lived Indy induces reduced mitochondrial reactive oxygen species production and oxidative damage. Proceedings of the National Academy of Sciences of the United States of America. 106: 2277-82. PMID 19164521 DOI: 10.1073/Pnas.0812484106  0.322
2008 Helfand SL, Bauer JH, Wood JG. 3 Calorie Restriction in Lower Organisms Cold Spring Harbor Monograph Archive. 51: 73-93. DOI: 10.1101/087969824.51.73  0.302
2007 Bauer JH, Chang C, Morris SN, Hozier S, Andersen S, Waitzman JS, Helfand SL. Expression of dominant-negative Dmp53 in the adult fly brain inhibits insulin signaling. Proceedings of the National Academy of Sciences of the United States of America. 104: 13355-60. PMID 17686972 DOI: 10.1073/Pnas.0706121104  0.309
2006 Sánchez-Blanco A, Fridell YW, Helfand SL. Involvement of Drosophila uncoupling protein 5 in metabolism and aging. Genetics. 172: 1699-710. PMID 16387864 DOI: 10.1534/genetics.105.053389  0.303
2005 Bauer JH, Poon PC, Glatt-Deeley H, Abrams JM, Helfand SL. Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span. Current Biology : Cb. 15: 2063-8. PMID 16303568 DOI: 10.1016/J.Cub.2005.10.051  0.331
2005 Fridell YW, Sánchez-Blanco A, Silvia BA, Helfand SL. Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly. Cell Metabolism. 1: 145-52. PMID 16054055 DOI: 10.1016/j.cmet.2005.01.005  0.301
2004 Rogina B, Helfand SL. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proceedings of the National Academy of Sciences of the United States of America. 101: 15998-6003. PMID 15520384 DOI: 10.1073/Pnas.0404184101  0.312
2004 Fridell YW, Sánchez-Blanco A, Silvia BA, Helfand SL. Functional characterization of a Drosophila mitochondrial uncoupling protein. Journal of Bioenergetics and Biomembranes. 36: 219-28. PMID 15337852 DOI: 10.1023/B:JOBB.0000031973.20153.c6  0.353
2004 Bauer JH, Goupil S, Garber GB, Helfand SL. An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America. 101: 12980-5. PMID 15328413 DOI: 10.1073/pnas.0403493101  0.347
2004 Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, Sinclair D. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature. 430: 686-9. PMID 15254550 DOI: 10.1038/Nature02789  0.327
2003 Helfand SL, Rogina B. Genetics of aging in the fruit fly, Drosophila melanogaster. Annual Review of Genetics. 37: 329-48. PMID 14616064 DOI: 10.1146/Annurev.Genet.37.040103.095211  0.328
2003 Helfand SL, Rogina B. From genes to aging in Drosophila. Advances in Genetics. 49: 67-109. PMID 12779251 DOI: 10.1016/S0065-2660(03)01002-2  0.311
2003 Marden JH, Rogina B, Montooth KL, Helfand SL. Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies. Proceedings of the National Academy of Sciences of the United States of America. 100: 3369-73. PMID 12626742 DOI: 10.1073/Pnas.0634985100  0.311
2003 Helfand SL, Rogina B. Molecular genetics of aging in the fly: is this the end of the beginning? Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 25: 134-41. PMID 12539239 DOI: 10.1002/Bies.10225  0.343
2003 Helfand SL, Inouye SK. Aging, life span, genetics and the fruit fly Clinical Neuroscience Research. 2: 270-278. DOI: 10.1016/S1566-2772(03)00003-3  0.306
2002 Rogina B, Helfand SL, Frankel S. Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction. Science (New York, N.Y.). 298: 1745. PMID 12459580 DOI: 10.1126/Science.1078986  0.349
2002 Knauf F, Rogina B, Jiang Z, Aronson PS, Helfand SL. Functional characterization and immunolocalization of the transporter encoded by the life-extending gene Indy. Proceedings of the National Academy of Sciences of the United States of America. 99: 14315-9. PMID 12391301 DOI: 10.1073/Pnas.222531899  0.313
2002 Hoopengardner B, Helfand SL. Temperature compensation and temporal expression mediated by an enhancer element in Drosophila. Mechanisms of Development. 110: 27-37. PMID 11744366 DOI: 10.1016/S0925-4773(01)00588-3  0.301
2000 Rogina B, Helfand SL. Cu, Zn superoxide dismutase deficiency accelerates the time course of an age-related marker in Drosophila melanogaster. Biogerontology. 1: 163-9. PMID 11707932 DOI: 10.1023/A:1010039813107  0.315
2000 Rogina B, Reenan RA, Nilsen SP, Helfand SL. Extended life-span conferred by cotransporter gene mutations in Drosophila. Science (New York, N.Y.). 290: 2137-40. PMID 11118146 DOI: 10.1126/Science.290.5499.2137  0.342
2000 Helfand SL, Rogina B. Regulation of gene expression during aging. Results and Problems in Cell Differentiation. 29: 67-80. PMID 10838695 DOI: 10.1007/978-3-540-48003-7_4  0.331
1998 Rogina B, Vaupel JW, Partridge L, Helfand SL. Regulation of gene expression is preserved in aging Drosophila melanogaster. Current Biology : Cb. 8: 475-8. PMID 9550706 DOI: 10.1016/S0960-9822(98)70184-8  0.365
1997 Rogina B, Helfand SL. Spatial and temporal pattern of expression of the wingless and engrailed genes in the adult antenna is regulated by age-dependent mechanisms. Mechanisms of Development. 63: 89-97. PMID 9178259 DOI: 10.1016/S0925-4773(97)00033-6  0.332
1997 Rogina B, Benzer S, Helfand SL. Drosophila drop-dead mutations accelerate the time course of age-related markers. Proceedings of the National Academy of Sciences of the United States of America. 94: 6303-6. PMID 9177212 DOI: 10.1073/Pnas.94.12.6303  0.366
1995 Blake KJ, Rogina B, Centurion A, Helfand SL. Changes in gene expression during post-eclosional development in the olfactory system of Drosophila melanogaster. Mechanisms of Development. 52: 179-85. PMID 8541207 DOI: 10.1016/0925-4773(95)00398-K  0.33
1991 Irvine KD, Helfand SL, Hogness DS. The large upstream control region of the Drosophila homeotic gene Ultrabithorax. Development (Cambridge, England). 111: 407-24. PMID 1680046  0.598
1989 McKenna M, Monte P, Helfand SL, Woodard C, Carlson J. A simple chemosensory response in Drosophila and the isolation of acj mutants in which it is affected. Proceedings of the National Academy of Sciences of the United States of America. 86: 8118-22. PMID 2510161 DOI: 10.1073/Pnas.86.20.8118  0.687
1989 Helfand SL, Carlson JR. Isolation and characterization of an olfactory mutant in Drosophila with a chemically specific defect. Proceedings of the National Academy of Sciences of the United States of America. 86: 2908-12. PMID 2495539 DOI: 10.1073/Pnas.86.8.2908  0.505
1985 Hogness DS, Lipshitz HD, Beachy PA, Peattie DA, Saint RB, Goldschmidt-Clermont M, Harte PJ, Gavis ER, Helfand SL. Regulation and products of the Ubx domain of the bithorax complex. Cold Spring Harbor Symposia On Quantitative Biology. 50: 181-94. PMID 3938361 DOI: 10.1101/Sqb.1985.050.01.024  0.561
1985 Beachy PA, Helfand SL, Hogness DS. Segmental distribution of bithorax complex proteins during Drosophila development. Nature. 313: 545-51. PMID 3918274 DOI: 10.1038/313545a0  0.581
1985 Bastiani MJ, Doe CQ, Helfand SL, Goodman CS. Neuronal specificity and growth cone guidance in grasshopper and Drosophila embryos Trends in Neurosciences. 8: 257-266. DOI: 10.1016/0166-2236(85)90099-2  0.717
1984 Goodman CS, Bastiani MJ, Doe CQ, du Lac S, Helfand SL, Kuwada JY, Thomas JB. Cell recognition during neuronal development. Science (New York, N.Y.). 225: 1271-9. PMID 6474176 DOI: 10.1126/Science.6474176  0.665
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