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Andrew J. Wiemer, Ph.D. - Publications

Affiliations: 
2008 University of Iowa, Iowa City, IA 
 2012- University of Connecticut, Storrs, CT, United States 
Area:
Biochemistry
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47 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Harmon NM, Huang X, Schladetsch MA, Hsiao CC, Wiemer AJ, Wiemer DF. Potent double prodrug forms of synthetic phosphoantigens. Bioorganic & Medicinal Chemistry. 28: 115666. PMID 32912439 DOI: 10.1016/J.Bmc.2020.115666  0.398
2020 Wiemer AJ. Structure-Activity Relationships of Butyrophilin 3 Ligands. Chemmedchem. PMID 32453919 DOI: 10.1002/Cmdc.202000198  0.371
2019 Li J, Lentini NA, Wiemer DF, Wiemer AJ. A luciferase lysis assay reveals in vivo malignant cell sensitization by phosphoantigen prodrugs. Biochemical Pharmacology. 113668. PMID 31628909 DOI: 10.1016/J.Bcp.2019.113668  0.413
2019 Agabiti SS, Li J, Dong W, Poe MM, Wiemer AJ. Regulation of the Notch-ATM-abl axis by geranylgeranyl diphosphate synthase inhibition. Cell Death & Disease. 10: 733. PMID 31570763 DOI: 10.1038/S41419-019-1973-7  0.45
2019 Reeve SM, Si D, Krucinska J, Yan Y, Viswanathan K, Wang S, Holt GT, Frenkel MS, Ojewole A, Estrada A, Agabiti SS, Alverson JB, Gibson ND, Priestly ND, Wiemer AJ, et al. Toward Broad Spectrum DHFR inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin-Resistant Staphylococcus aureus. Acs Infectious Diseases. PMID 31565920 DOI: 10.1021/Acsinfecdis.9B00222  0.351
2019 Lentini NA, Hsiao CC, Crull GB, Wiemer AJ, Wiemer DF. Synthesis and Bioactivity of the Alanyl Phosphonamidate Stereoisomers Derived from a Butyrophilin Ligand. Acs Medicinal Chemistry Letters. 10: 1284-1289. PMID 31531198 DOI: 10.1021/Acsmedchemlett.9B00153  0.359
2019 Foust BJ, Li J, Hsiao CC, Wiemer DF, Wiemer AJ. Stability and Efficiency of Mixed Aryl Phosphonate Prodrugs. Chemmedchem. PMID 31226236 DOI: 10.1002/Cmdc.201900344  0.319
2018 Haney SL, Varney ML, Safranek HR, Chhonker YS, G-Dayanandan N, Talmon G, Murry DJ, Wiemer AJ, Wright DL, Holstein SA. Tropolone-induced effects on the unfolded protein response pathway and apoptosis in multiple myeloma cells are dependent on iron. Leukemia Research. 77: 17-27. PMID 30612055 DOI: 10.1016/J.Leukres.2018.12.007  0.312
2018 Hsiao CC, Wiemer AJ. A power law function describes the time- and dose-dependency of Vγ9Vδ2 T cell activation by phosphoantigens. Biochemical Pharmacology. PMID 30391478 DOI: 10.1016/J.Bcp.2018.10.035  0.372
2018 Lentini N, Foust BJ, Hsiao CC, Wiemer AJ, Wiemer DF. Phosphonamidate prodrugs of a butyrophilin ligand display plasma stability and potent Vγ9Vδ2 T cell stimulation. Journal of Medicinal Chemistry. PMID 30199251 DOI: 10.1021/Acs.Jmedchem.8B00655  0.367
2017 Haney SL, Allen C, Varney ML, Dykstra KM, Falcone ER, Colligan SH, Hu Q, Aldridge AM, Wright DL, Wiemer AJ, Holstein SA. Novel tropolones induce the unfolded protein response pathway and apoptosis in multiple myeloma cells. Oncotarget. 8: 76085-76098. PMID 29100294 DOI: 10.18632/Oncotarget.18543  0.424
2017 Foust BJ, Poe MM, Lentini NA, Hsiao CC, Wiemer AJ, Wiemer DF. Mixed Aryl Phosphonate Prodrugs of a Butyrophilin Ligand. Acs Medicinal Chemistry Letters. 8: 914-918. PMID 28947936 DOI: 10.1021/Acsmedchemlett.7B00245  0.374
2017 Haney SL, Allen C, Varney ML, Dykstra KM, Falcone ER, Colligan SH, Hu Q, Aldridge AM, Wright DL, Wiemer AJ, Holstein SA. Novel tropolones induce the unfolded protein response pathway and apoptosis in multiple myeloma cells. Oncotarget. PMID 28636534 DOI: 10.18632/oncotarget.18543  0.317
2017 Agabiti SS, Li J, Wiemer AJ. Geranylgeranyl diphosphate synthase inhibition induces apoptosis that is dependent upon GGPP depletion, ERK phosphorylation and caspase activation. Cell Death & Disease. 8: e2678. PMID 28300835 DOI: 10.1038/Cddis.2017.101  0.425
2017 Shippy RR, Lin X, Agabiti SS, Li J, Zangari BM, Foust BJ, Poe MM, Hsiao CC, Vinogradova O, Wiemer DF, Wiemer AJ. Phosphinophosphonates and their tris-pivaloyloxymethyl prodrugs reveal a negatively cooperative butyrophilin activation mechanism. Journal of Medicinal Chemistry. PMID 28218845 DOI: 10.1021/Acs.Jmedchem.6B00965  0.422
2016 Li J, Falcone ER, Holstein SA, Anderson AC, Wright DL, Wiemer AJ. Novel α-substituted tropolones promote potent and selective caspase-dependent leukemia cell apoptosis. Pharmacological Research. PMID 27663262 DOI: 10.1016/J.Phrs.2016.09.020  0.376
2016 Gromek SM, deMayo JA, Maxwell AT, West AM, Pavlik CM, Zhao Z, Li J, Wiemer AJ, Zweifach A, Balunas MJ. Synthesis and biological evaluation of santacruzamate A analogues for anti-proliferative and immunomodulatory activity. Bioorganic & Medicinal Chemistry. PMID 27614919 DOI: 10.1016/J.Bmc.2016.08.040  0.421
2016 Agabiti SS, Liang Y, Wiemer AJ. Molecular mechanisms linking geranylgeranyl diphosphate synthase to cell survival and proliferation. Molecular Membrane Biology. 1-11. PMID 27537059 DOI: 10.1080/09687688.2016.1213432  0.442
2016 Kilcollins AM, Li J, Hsiao CC, Wiemer AJ. HMBPP Analog Prodrugs Bypass Energy-Dependent Uptake To Promote Efficient BTN3A1-Mediated Malignant Cell Lysis by Vγ9Vδ2 T Lymphocyte Effectors. Journal of Immunology (Baltimore, Md. : 1950). PMID 27271567 DOI: 10.4049/Jimmunol.1501833  0.429
2015 Wiemer AJ, Shippy RR, Kilcollins AM, Li J, Hsiao CC, Barney RJ, Geng ML, Wiemer DF. Evaluation of a 7-methoxycoumarin-3-carboxylic acid ester derivative as a fluorescent, cell-cleavable, phosphonate protecting group. Chembiochem : a European Journal of Chemical Biology. PMID 26503489 DOI: 10.1002/Cbic.201500484  0.405
2015 Wiemer AJ, Wiemer DF. Prodrugs of phosphonates and phosphates: crossing the membrane barrier. Topics in Current Chemistry. 360: 115-60. PMID 25391982 DOI: 10.1007/128_2014_561  0.319
2015 Aldridge AM, Dykstra KM, Allen C, Colligan SH, Falcone ER, Wiemer AJ, Wright DL, Holstein SA. Effects of Novel Tropolones with Selective HDAC Inhibitor Activity in Myeloma Cells Blood. 126: 3247-3247. DOI: 10.1182/Blood.V126.23.3247.3247  0.429
2014 Hsiao CH, Lin X, Barney RJ, Shippy RR, Li J, Vinogradova O, Wiemer DF, Wiemer AJ. Synthesis of a phosphoantigen prodrug that potently activates Vγ9Vδ2 T-lymphocytes. Chemistry & Biology. 21: 945-54. PMID 25065532 DOI: 10.1016/J.Chembiol.2014.06.006  0.406
2014 Wiemer DF, Wiemer AJ. Opportunities and challenges in development of phosphoantigens as Vγ9Vδ2 T cell agonists. Biochemical Pharmacology. 89: 301-12. PMID 24680696 DOI: 10.1016/J.Bcp.2014.03.009  0.348
2013 Wiemer AJ, Wernimont SA, Cung TD, Bennin DA, Beggs HE, Huttenlocher A. The focal adhesion kinase inhibitor PF-562,271 impairs primary CD4+ T cell activation. Biochemical Pharmacology. 86: 770-81. PMID 23928188 DOI: 10.1016/J.Bcp.2013.07.024  0.587
2012 Wiemer AJ, Wernimont S, Huttenlocher A. Live imaging of LFA-1-dependent T-cell motility and stop signals. Methods in Molecular Biology (Clifton, N.J.). 757: 191-204. PMID 21909914 DOI: 10.1007/978-1-61779-166-6_13  0.56
2011 Wernimont SA, Wiemer AJ, Bennin DA, Monkley SJ, Ludwig T, Critchley DR, Huttenlocher A. Contact-dependent T cell activation and T cell stopping require talin1. Journal of Immunology (Baltimore, Md. : 1950). 187: 6256-67. PMID 22075696 DOI: 10.4049/Jimmunol.1102028  0.551
2011 Wiemer AJ, Wiemer DF, Hohl RJ. Geranylgeranyl diphosphate synthase: an emerging therapeutic target. Clinical Pharmacology and Therapeutics. 90: 804-12. PMID 22048229 DOI: 10.1038/Clpt.2011.215  0.556
2011 Wiemer AJ, Hegde S, Gumperz JE, Huttenlocher A. A live imaging cell motility screen identifies prostaglandin E2 as a T cell stop signal antagonist. Journal of Immunology (Baltimore, Md. : 1950). 187: 3663-70. PMID 21900181 DOI: 10.4049/Jimmunol.1100103  0.588
2010 Wiemer AJ, Hsiao CH, Wiemer DF. Isoprenoid metabolism as a therapeutic target in gram-negative pathogens. Current Topics in Medicinal Chemistry. 10: 1858-71. PMID 20615187 DOI: 10.2174/156802610793176602  0.346
2010 Wiemer AJ, Lokuta MA, Surfus JC, Wernimont SA, Huttenlocher A. Calpain inhibition impairs TNF-alpha-mediated neutrophil adhesion, arrest and oxidative burst. Molecular Immunology. 47: 894-902. PMID 19889458 DOI: 10.1016/J.Molimm.2009.10.002  0.504
2009 Wiemer AJ, Hohl RJ, Wiemer DF. The intermediate enzymes of isoprenoid metabolism as anticancer targets. Anti-Cancer Agents in Medicinal Chemistry. 9: 526-42. PMID 19519294 DOI: 10.2174/187152009788451860  0.626
2008 Tong H, Wiemer AJ, Neighbors JD, Hohl RJ. Quantitative determination of farnesyl and geranylgeranyl diphosphate levels in mammalian tissue. Analytical Biochemistry. 378: 138-43. PMID 18457649 DOI: 10.1016/J.Ab.2008.04.021  0.52
2008 Wiemer AJ, Yu JS, Shull LW, Barney RJ, Wasko BM, Lamb KM, Hohl RJ, Wiemer DF. Pivaloyloxymethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation. Bioorganic & Medicinal Chemistry. 16: 3652-60. PMID 18308574 DOI: 10.1016/J.Bmc.2008.02.016  0.65
2008 Dudakovic A, Wiemer AJ, Lamb KM, Vonnahme LA, Dietz SE, Hohl RJ. Inhibition of geranylgeranyl diphosphate synthase induces apoptosis through multiple mechanisms and displays synergy with inhibition of other isoprenoid biosynthetic enzymes. The Journal of Pharmacology and Experimental Therapeutics. 324: 1028-36. PMID 18083912 DOI: 10.1124/Jpet.107.132217  0.713
2008 Wiemer AJ, Yu JS, Lamb KM, Hohl RJ, Wiemer DF. Mono- and dialkyl isoprenoid bisphosphonates as geranylgeranyl diphosphate synthase inhibitors. Bioorganic & Medicinal Chemistry. 16: 390-9. PMID 17905588 DOI: 10.1016/J.Bmc.2007.09.029  0.642
2007 Maalouf MA, Wiemer AJ, Kuder CH, Hohl RJ, Wiemer DF. Synthesis of fluorescently tagged isoprenoid bisphosphonates that inhibit protein geranylgeranylation. Bioorganic & Medicinal Chemistry. 15: 1959-66. PMID 17254791 DOI: 10.1016/J.Bmc.2007.01.002  0.72
2007 Mente NR, Wiemer AJ, Neighbors JD, Beutler JA, Hohl RJ, Wiemer DF. Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: differences of bioactivity in the enantiomeric series. Bioorganic & Medicinal Chemistry Letters. 17: 911-5. PMID 17236766 DOI: 10.1016/J.Bmcl.2006.11.096  0.484
2007 Wiemer AJ, Tong H, Swanson KM, Hohl RJ. Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase. Biochemical and Biophysical Research Communications. 353: 921-5. PMID 17208200 DOI: 10.1016/J.Bbrc.2006.12.094  0.636
2006 Shull LW, Wiemer AJ, Hohl RJ, Wiemer DF. Synthesis and biological activity of isoprenoid bisphosphonates. Bioorganic & Medicinal Chemistry. 14: 4130-6. PMID 16517172 DOI: 10.1016/J.Bmc.2006.02.010  0.608
2006 Askeland EJ, Wiemer AJ, Hohl RJ. Synergism between Anti-Leukemia Therapeutics and Isoprenoid Pathway Inhibitors in K562 Leukemia Cells. Blood. 108: 4815-4815. DOI: 10.1182/Blood.V108.11.4815.4815  0.624
2005 Swanson KM, Tong H, Wiemer AJ, Murthy S, Hohl RJ. Potential mechanisms for the anti-myeloma properties of bisphosphonates Journal of Clinical Oncology. 23: 6586-6586. DOI: 10.1200/Jco.2005.23.16_Suppl.6586  0.631
2004 Kim M, Kleckley TS, Wiemer AJ, Holstein SA, Hohl RJ, Wiemer DF. Synthesis and activity of fluorescent isoprenoid pyrophosphate analogues. The Journal of Organic Chemistry. 69: 8186-93. PMID 15549786 DOI: 10.1021/Jo049101W  0.6
2004 Swanson KM, Wiemer AJ, Hohl RJ. Bisphosphonates Influence Isoprenylation of Small Gtpases in Human Myeloma Cells. Blood. 104: 3401-3401. DOI: 10.1182/Blood.V104.11.3401.3401  0.629
2002 Chen X, Wiemer AJ, Hohl RJ, Wiemer DF. Stereoselective synthesis of the 5'-hydroxy-5'-phosphonate derivatives of cytidine and cytosine arabinoside. The Journal of Organic Chemistry. 67: 9331-9. PMID 12492335 DOI: 10.1021/Jo020483K  0.568
2002 Chen X, Jung KY, Wiemer DF, Wiemer AJ, Hohl RJ. Phosphonate analogues of cytosine arabinoside monophosphate Phosphorus, Sulfur and Silicon and Related Elements. 177: 1783-1786. DOI: 10.1080/10426500212248  0.575
2000 Jung KY, Hohl RJ, Wiemer AJ, Wiemer DF. Synthesis of phosphonate derivatives of uridine, cytidine, and cytosine arabinoside. Bioorganic & Medicinal Chemistry. 8: 2501-9. PMID 11058045 DOI: 10.1016/S0968-0896(00)00183-8  0.582
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