Robert Farese - Publications

Affiliations: 
Cell Biology University of California, San Francisco, San Francisco, CA 
Area:
Cell Biology

136 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Chitraju C, Fischer AW, Farese RV, Walther TC. Lipid Droplets in Brown Adipose Tissue Are Dispensable for Cold-Induced Thermogenesis. Cell Reports. 33: 108348. PMID 33147469 DOI: 10.1016/j.celrep.2020.108348  0.8
2020 Becuwe M, Bond LM, Pinto AFM, Boland S, Mejhert N, Elliott SD, Cicconet M, Graham MM, Liu XN, Ilkayeva O, Saghatelian A, Walther TC, Farese RV. FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis. The Journal of Cell Biology. 219. PMID 32915949 DOI: 10.1083/jcb.202006111  0.8
2020 Zhang J, Velmeshev D, Hashimoto K, Huang YH, Hofmann JW, Shi X, Chen J, Leidal AM, Dishart JG, Cahill MK, Kelley KW, Liddelow SA, Seeley WW, Miller BL, Walther TC, ... Farese RV, et al. Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency. Nature. PMID 32866962 DOI: 10.1038/s41586-020-2709-7  0.8
2020 Olarte MJ, Kim S, Sharp ME, Swanson JMJ, Farese RV, Walther TC. Determinants of Endoplasmic Reticulum-to-Lipid Droplet Protein Targeting. Developmental Cell. PMID 32730754 DOI: 10.1016/j.devcel.2020.07.001  0.8
2020 Sui X, Wang K, Gluchowski NL, Elliott SD, Liao M, Walther TC, Farese RV. Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme. Nature. 581: 323-328. PMID 32433611 DOI: 10.1038/s41586-020-2289-6  0.8
2020 Petit CS, Lee JJ, Boland S, Swarup S, Christiano R, Lai ZW, Mejhert N, Elliott SD, McFall D, Haque S, Huang EJ, Bronson RT, Harper JW, Farese RV, Walther TC. Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant mice, a model of motor neuron degeneration. Proceedings of the National Academy of Sciences of the United States of America. PMID 32345721 DOI: 10.1073/pnas.1913956117  0.8
2020 Mejhert N, Kuruvilla L, Gabriel KR, Elliott SD, Guie MA, Wang H, Lai ZW, Lane EA, Christiano R, Danial NN, Farese RV, Walther TC. Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression. Molecular Cell. PMID 32023484 DOI: 10.1016/j.molcel.2020.01.014  0.8
2019 Chung J, Wu X, Lambert TJ, Lai ZW, Walther TC, Farese RV. LDAF1 and Seipin Form a Lipid Droplet Assembly Complex. Developmental Cell. PMID 31708432 DOI: 10.1016/j.devcel.2019.10.006  0.8
2019 Walther TC, Farese RV. Un-phased: Lipid Droplets Modulate the Bioavailability of Antibiotics. Developmental Cell. 50: 530-532. PMID 31505174 DOI: 10.1016/j.devcel.2019.08.009  0.8
2019 Gluchowski NL, Gabriel KR, Chitraju C, Bronson RT, Mejhert N, Boland S, Wang K, Lai ZW, Farese RV, Walther TC. Hepatocyte Deletion of Triglyceride-Synthesis Enzyme DGAT2 Reduces Steatosis without Increasing Inflammation or Fibrosis. Hepatology (Baltimore, Md.). PMID 31081165 DOI: 10.1002/hep.30765  0.8
2019 Chitraju C, Walther TC, Farese RV. The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes. Journal of Lipid Research. 60: 1112-1120. PMID 30936184 DOI: 10.1194/jlr.M093112  0.8
2019 Piccolis M, Bond LM, Kampmann M, Pulimeno P, Chitraju C, Jayson CBK, Vaites LP, Boland S, Lai ZW, Gabriel KR, Elliott SD, Paulo JA, Harper JW, Weissman JS, Walther TC, ... Farese RV, et al. Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids. Molecular Cell. PMID 30846318 DOI: 10.1016/j.molcel.2019.01.036  0.8
2018 Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, ... ... Farese RV, et al. Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. Molecular Cell. PMID 30527540 DOI: 10.1016/j.molcel.2018.11.028  0.8
2018 Sui X, Arlt H, Brock KP, Lai ZW, DiMaio F, Marks DS, Liao M, Farese RV, Walther TC. Cryo-electron microscopy structure of the lipid droplet-formation protein seipin. The Journal of Cell Biology. PMID 30327422 DOI: 10.1083/jcb.201809067  0.8
2018 Nguyen AD, Nguyen TA, Singh RK, Eberlé D, Zhang J, Abate JP, Robles A, Koliwad S, Huang EJ, Maxfield FR, Walther TC, Farese RV. Progranulin in the hematopoietic compartment protects mice from atherosclerosis. Atherosclerosis. 277: 145-154. PMID 30212683 DOI: 10.1016/j.atherosclerosis.2018.08.042  0.8
2018 Jayson CBK, Arlt H, Fischer AW, Lai ZW, Farese RV, Walther TC. Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells. Molecular Biology of the Cell. mbcE18050282. PMID 29949452 DOI: 10.1091/mbc.E18-05-0282  0.8
2018 Nguyen AD, Nguyen TA, Zhang J, Devireddy S, Zhou P, Karydas AM, Xu X, Miller BL, Rigo F, Ferguson SM, Huang EJ, Walther TC, Farese RV. Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay. Proceedings of the National Academy of Sciences of the United States of America. PMID 29511098 DOI: 10.1073/pnas.1722344115  0.8
2018 Li Z, Lai ZW, Christiano R, Gazos-Lopes F, Walther TC, Farese RV. Global Analyses of Selective Insulin Resistance in Hepatocytes due to Palmitate Lipotoxicity. Molecular & Cellular Proteomics : McP. PMID 29414761 DOI: 10.1074/mcp.RA117.000560  0.8
2018 Prévost C, Sharp ME, Kory N, Lin Q, Voth GA, Farese RV, Walther TC. Mechanism and Determinants of Amphipathic Helix-Containing Protein Targeting to Lipid Droplets. Developmental Cell. 44: 73-86.e4. PMID 29316443 DOI: 10.1016/j.devcel.2017.12.011  0.8
2017 Inloes JM, Kiosses WB, Wang H, Walther TC, Farese RV, Cravatt BF. Functional Contribution of the Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2 to the Formation and Content of Lipid Droplets. Biochemistry. PMID 29278326 DOI: 10.1021/acs.biochem.7b01028  0.8
2017 Walther TC, Chung J, Farese RV. Lipid Droplet Biogenesis. Annual Review of Cell and Developmental Biology. PMID 28793795 DOI: 10.1146/annurev-cellbio-100616-060608  0.8
2017 Chitraju C, Mejhert N, Haas JT, Diaz-Ramirez LG, Grueter CA, Imbriglio JE, Pinto S, Koliwad SK, Walther TC, Farese RV. Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis. Cell Metabolism. 26: 407-418.e3. PMID 28768178 DOI: 10.1016/j.cmet.2017.07.012  0.8
2017 Gluchowski NL, Becuwe M, Walther TC, Farese RV. Lipid droplets and liver disease: from basic biology to clinical implications. Nature Reviews. Gastroenterology & Hepatology. 14: 343-355. PMID 28428634 DOI: 10.1038/nrgastro.2017.32  0.8
2017 Gluchowski NL, Chitraju C, Picoraro JA, Mejhert N, Pinto S, Xin W, Kamin DS, Winter HS, Chung WK, Walther TC, Farese RV. Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea. Journal of Lipid Research. PMID 28373485 DOI: 10.1194/jlr.P075119  0.8
2016 Kory N, Grond S, Kamat SS, Li Z, Krahmer N, Chitraju C, Zhou P, Fröhlich F, Semova I, Ejsing C, Zechner R, Cravatt BF, Farese RV, Walther TC. Mice Lacking Lipid Droplet-Associated Hydrolase, a Gene Linked to Human Prostate Cancer, Have Normal Cholesterol Ester Metabolism. Journal of Lipid Research. PMID 27836991 DOI: 10.1194/jlr.M072538  0.8
2016 Fröhlich F, Olson DK, Christiano R, Farese RV, Walther TC. Proteomic and phosphoproteomic analyses of yeast reveal the global cellular response to sphingolipid depletion. Proteomics. 16: 2759-2763. PMID 27717283 DOI: 10.1002/pmic.201600269  0.8
2016 Wang H, Becuwe M, Housden BE, Chitraju C, Porras AJ, Graham MM, Liu XN, Thiam AR, Savage DB, Agarwal AK, Garg A, Olarte MJ, Lin Q, Fröhlich F, Hannibal-Bach HK, ... ... Farese RV, et al. Seipin is required for converting nascent to mature lipid droplets. Elife. 5. PMID 27564575 DOI: 10.7554/eLife.16582  0.8
2016 Kory N, Farese RV, Walther TC. Targeting Fat: Mechanisms of Protein Localization to Lipid Droplets. Trends in Cell Biology. 26: 535-546. PMID 26995697 DOI: 10.1016/j.tcb.2016.02.007  0.8
2016 Farese RV, Walther TC. Lipid droplets go nuclear. The Journal of Cell Biology. 212: 7-8. PMID 26728852 DOI: 10.1083/jcb.201512056  0.8
2016 Kory N, Farese RV, Walther TC. Targeting Fat: Mechanisms of Protein Localization to Lipid Droplets Trends in Cell Biology. 26: 535-546. DOI: 10.1016/j.tcb.2016.02.007  0.8
2015 Fröhlich F, Petit C, Kory N, Christiano R, Hannibal-Bach HK, Graham M, Liu X, Ejsing CS, Farese RV, Walther TC. The GARP complex is required for cellular sphingolipid homeostasis. Elife. 4. PMID 26357016 DOI: 10.7554/eLife.08712  0.8
2015 Kory N, Thiam AR, Farese RV, Walther TC. Protein Crowding Is a Determinant of Lipid Droplet Protein Composition. Developmental Cell. 34: 351-63. PMID 26212136 DOI: 10.1016/j.devcel.2015.06.007  0.8
2015 Olson DK, Fröhlich F, Farese RV, Walther TC. Taming the sphinx: Mechanisms of cellular sphingolipid homeostasis Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids. DOI: 10.1016/j.bbalip.2015.12.021  0.8
2014 Mul JD, Begg DP, Haller AM, Pressler JW, Sorrell J, Woods SC, Farese RV, Seeley RJ, Sandoval DA. MGAT2 deficiency and vertical sleeve gastrectomy have independent metabolic effects in the mouse. American Journal of Physiology. Endocrinology and Metabolism. 307: E1065-72. PMID 25315695 DOI: 10.1152/ajpendo.00376.2014  0.8
2014 Liu L, Trent CM, Fang X, Son NH, Jiang H, Blaner WS, Hu Y, Yin YX, Farese RV, Homma S, Turnbull AV, Eriksson JW, Hu SL, Ginsberg HN, Huang LS, et al. Cardiomyocyte-specific loss of diacylglycerol acyltransferase 1 (DGAT1) reproduces the abnormalities in lipids found in severe heart failure. The Journal of Biological Chemistry. 289: 29881-91. PMID 25157099 DOI: 10.1074/jbc.M114.601864  0.8
2014 Ward ME, Taubes A, Chen R, Miller BL, Sephton CF, Gelfand JM, Minami S, Boscardin J, Martens LH, Seeley WW, Yu G, Herz J, Filiano AJ, Arrant AE, Roberson ED, ... ... Farese RV, et al. Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD. The Journal of Experimental Medicine. 211: 1937-45. PMID 25155018 DOI: 10.1084/jem.20140214  0.8
2014 Fu D, Yu Y, Folick A, Currie E, Farese RV, Tsai TH, Xie XS, Wang MC. In vivo metabolic fingerprinting of neutral lipids with hyperspectral stimulated Raman scattering microscopy. Journal of the American Chemical Society. 136: 8820-8. PMID 24869754 DOI: 10.1021/ja504199s  0.8
2014 Currie E, Guo X, Christiano R, Chitraju C, Kory N, Harrison K, Haas J, Walther TC, Farese RV. High confidence proteomic analysis of yeast LDs identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol acetylation. Journal of Lipid Research. 55: 1465-1477. PMID 24868093 DOI: 10.1194/jlr.M050229  0.8
2014 Wilfling F, Haas JT, Walther TC, Farese RV. Lipid droplet biogenesis. Current Opinion in Cell Biology. 29: 39-45. PMID 24736091 DOI: 10.1016/j.ceb.2014.03.008  0.8
2014 Wilfling F, Thiam AR, Olarte MJ, Wang J, Beck R, Gould TJ, Allgeyer ES, Pincet F, Bewersdorf J, Farese RV, Walther TC. Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting. Elife. 3: e01607. PMID 24497546 DOI: 10.7554/eLife.01607  0.8
2013 Thiam AR, Farese RV, Walther TC. The biophysics and cell biology of lipid droplets. Nature Reviews. Molecular Cell Biology. 14: 775-86. PMID 24220094 DOI: 10.1038/nrm3699  0.8
2013 Nguyen AD, Nguyen TA, Martens LH, Mitic LL, Farese RV. Progranulin: at the interface of neurodegenerative and metabolic diseases. Trends in Endocrinology and Metabolism: Tem. 24: 597-606. PMID 24035620 DOI: 10.1016/j.tem.2013.08.003  0.8
2013 Currie E, Schulze A, Zechner R, Walther TC, Farese RV. Cellular fatty acid metabolism and cancer. Cell Metabolism. 18: 153-61. PMID 23791484 DOI: 10.1016/j.cmet.2013.05.017  0.8
2013 Krahmer N, Farese RV, Walther TC. Balancing the fat: Lipid droplets and human disease Embo Molecular Medicine. 5: 905-915. PMID 23740690 DOI: 10.1002/emmm.201100671  0.8
2013 Chen X, Chang J, Deng Q, Xu J, Nguyen TA, Martens LH, Cenik B, Taylor G, Hudson KF, Chung J, Yu K, Yu P, Herz J, Farese RV, Kukar T, et al. Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 9202-13. PMID 23699531 DOI: 10.1523/JNEUROSCI.5336-12.2013  0.8
2013 Klemm RW, Norton JP, Cole RA, Li CS, Park SH, Crane MM, Li L, Jin D, Boye-Doe A, Liu TY, Shibata Y, Lu H, Rapoport TA, Farese RV, Blackstone C, et al. A conserved role for atlastin GTPases in regulating lipid droplet size. Cell Reports. 3: 1465-75. PMID 23684613 DOI: 10.1016/j.celrep.2013.04.015  0.8
2013 Filiano AJ, Martens LH, Young AH, Warmus BA, Zhou P, Diaz-Ramirez G, Jiao J, Zhang Z, Huang EJ, Gao FB, Farese RV, Roberson ED. Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 5352-61. PMID 23516300 DOI: 10.1523/JNEUROSCI.6103-11.2013  0.8
2013 Wilfling F, Wang H, Haas JT, Krahmer N, Gould TJ, Uchida A, Cheng JX, Graham M, Christiano R, Fröhlich F, Liu X, Buhman KK, Coleman RA, Bewersdorf J, Farese RV, et al. Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. Developmental Cell. 24: 384-99. PMID 23415954 DOI: 10.1016/j.devcel.2013.01.013  0.8
2013 Nguyen AD, Nguyen TA, Cenik B, Yu G, Herz J, Walther TC, Davidson WS, Farese RV. Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL). The Journal of Biological Chemistry. 288: 8627-35. PMID 23364791 DOI: 10.1074/jbc.M112.441949  0.8
2013 Krahmer N, Hilger M, Kory N, Wilfling F, Stoehr G, Mann M, Farese RV, Walther TC. Protein correlation profiles identify lipid droplet proteins with high confidence. Molecular & Cellular Proteomics : McP. 12: 1115-26. PMID 23319140 DOI: 10.1074/mcp.M112.020230  0.8
2013 Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, Grueter CA, Lim H, Saunders LR, Stevens RD, Newgard CB, Farese RV, de Cabo R, Ulrich S, Akassoglou K, et al. Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science (New York, N.Y.). 339: 211-4. PMID 23223453 DOI: 10.1126/science.1227166  0.8
2013 Boxer AL, Gold M, Huey E, Hu WT, Rosen H, Kramer J, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, ... ... Farese R, et al. The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier). Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 189-98. PMID 23062850 DOI: 10.1016/j.jalz.2012.03.003  0.8
2013 Boxer AL, Gold M, Huey E, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, Mackenzie IR, Mitic L, Roberson ED, ... ... Farese R, et al. Frontotemporal degeneration, the next therapeutic frontier: molecules and animal models for frontotemporal degeneration drug development. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 176-88. PMID 23043900 DOI: 10.1016/j.jalz.2012.03.002  0.8
2012 Haas JT, Winter HS, Lim E, Kirby A, Blumenstiel B, DeFelice M, Gabriel S, Jalas C, Branski D, Grueter CA, Toporovski MS, Walther TC, Daly MJ, Farese RV. DGAT1 mutation is linked to a congenital diarrheal disorder. The Journal of Clinical Investigation. 122: 4680-4. PMID 23114594 DOI: 10.1172/JCI64873  0.8
2012 Armakola M, Higgins MJ, Figley MD, Barmada SJ, Scarborough EA, Diaz Z, Fang X, Shorter J, Krogan NJ, Finkbeiner S, Farese RV, Gitler AD. Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models. Nature Genetics. 44: 1302-9. PMID 23104007 DOI: 10.1038/ng.2434  0.8
2012 Eichmann TO, Kumari M, Haas JT, Farese RV, Zimmermann R, Lass A, Zechner R. Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases. The Journal of Biological Chemistry. 287: 41446-57. PMID 23066022 DOI: 10.1074/jbc.M112.400416  0.4
2012 Almeida S, Zhang Z, Coppola G, Mao W, Futai K, Karydas A, Geschwind MD, Tartaglia MC, Gao F, Gianni D, Sena-Esteves M, Geschwind DH, Miller BL, Farese RV, Gao FB. Induced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects. Cell Reports. 2: 789-98. PMID 23063362 DOI: 10.1016/j.celrep.2012.09.007  0.8
2012 Martens LH, Zhang J, Barmada SJ, Zhou P, Kamiya S, Sun B, Min SW, Gan L, Finkbeiner S, Huang EJ, Farese RV. Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury. The Journal of Clinical Investigation. 122: 3955-9. PMID 23041626 DOI: 10.1172/JCI63113  0.8
2012 Xu N, Zhang SO, Cole RA, McKinney SA, Guo F, Haas JT, Bobba S, Farese RV, Mak HY. The FATP1-DGAT2 complex facilitates lipid droplet expansion at the ER-lipid droplet interface. The Journal of Cell Biology. 198: 895-911. PMID 22927462 DOI: 10.1083/jcb.201201139  0.8
2012 Haas JT, Miao J, Chanda D, Wang Y, Zhao E, Haas ME, Hirschey M, Vaitheesvaran B, Farese RV, Kurland IJ, Graham M, Crooke R, Foufelle F, Biddinger SB. Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression. Cell Metabolism. 15: 873-84. PMID 22682225 DOI: 10.1016/j.cmet.2012.05.002  0.8
2012 Farese RV, Zechner R, Newgard CB, Walther TC. The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance Cell Metabolism. 15: 570-573. PMID 22560209 DOI: 10.1016/j.cmet.2012.03.004  0.8
2012 Walther TC, Farese RV. Lipid droplets and cellular lipid metabolism Annual Review of Biochemistry. 81: 687-714. PMID 22524315 DOI: 10.1146/annurev-biochem-061009-102430  0.8
2012 Zhang J, Kelley KL, Marshall SM, Davis MA, Wilson MD, Sawyer JK, Farese RV, Brown JM, Rudel LL. Tissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood. Journal of Lipid Research. 53: 1144-52. PMID 22460046 DOI: 10.1194/jlr.M024356  0.8
2012 Streeper RS, Grueter CA, Salomonis N, Cases S, Levin MC, Koliwad SK, Zhou P, Hirschey MD, Verdin E, Farese RV. Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice. Aging. 4: 13-27. PMID 22291164  0.8
2012 Tschöp MH, Speakman JR, Arch JR, Auwerx J, Brüning JC, Chan L, Eckel RH, Farese RV, Galgani JE, Hambly C, Herman MA, Horvath TL, Kahn BB, Kozma SC, Maratos-Flier E, et al. A guide to analysis of mouse energy metabolism. Nature Methods. 9: 57-63. PMID 22205519 DOI: 10.1038/nmeth.1806  0.8
2011 Krahmer N, Guo Y, Wilfling F, Hilger M, Lingrell S, Heger K, Newman HW, Schmidt-Supprian M, Vance DE, Mann M, Farese RV, Walther TC. Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase. Cell Metabolism. 14: 504-15. PMID 21982710 DOI: 10.1016/j.cmet.2011.07.013  0.8
2011 Rosen EY, Wexler EM, Versano R, Coppola G, Gao F, Winden KD, Oldham MC, Martens LH, Zhou P, Farese RV, Geschwind DH. Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling. Neuron. 71: 1030-42. PMID 21943601 DOI: 10.1016/j.neuron.2011.07.021  0.8
2011 Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, Stančáková A, Goetzman E, Lam MM, Schwer B, Stevens RD, Muehlbauer MJ, Kakar S, Bass NM, Kuusisto J, ... ... Farese RV, et al. SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Molecular Cell. 44: 177-90. PMID 21856199 DOI: 10.1016/j.molcel.2011.07.019  0.8
2011 Monetti M, Levin MC, Watt MJ, Hubbard BK, Newgard C, Farese RV, Hevener AL, Farese RV. Hepatic acyl-CoA:diacylglcyerol acyltransferase (DGAT) overexpression, diacylglycerol, and insulin sensitivity. Proceedings of the National Academy of Sciences of the United States of America. 108: E523; author reply E. PMID 21807991 DOI: 10.1073/pnas.1108505108  0.8
2011 Cenik B, Sephton CF, Dewey CM, Xian X, Wei S, Yu K, Niu W, Coppola G, Coughlin SE, Lee SE, Dries DR, Almeida S, Geschwind DH, Gao FB, Miller BL, ... Farese RV, et al. Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia. The Journal of Biological Chemistry. 286: 16101-8. PMID 21454553 DOI: 10.1074/jbc.M110.193433  0.8
2011 Kao AW, Eisenhut RJ, Martens LH, Nakamura A, Huang A, Bagley JA, Zhou P, de Luis A, Neukomm LJ, Cabello J, Farese RV, Kenyon C. A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells. Proceedings of the National Academy of Sciences of the United States of America. 108: 4441-6. PMID 21368173 DOI: 10.1073/pnas.1100650108  0.8
2011 Harris CA, Haas JT, Streeper RS, Stone SJ, Kumari M, Yang K, Han X, Brownell N, Gross RW, Zechner R, Farese RV. DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes. Journal of Lipid Research. 52: 657-67. PMID 21317108 DOI: 10.1194/jlr.M013003  0.8
2011 Bewersdorf J, Farese RV, Walther TC. A new way to look at fat Nature Methods. 8: 132-133. PMID 21278725 DOI: 10.1038/nmeth0211-132  0.8
2010 Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, ... ... Farese RV, et al. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 464: 121-5. PMID 20203611 DOI: 10.1038/nature08778  0.8
2009 Krahmer N, Guo Y, Farese RV, Walther TC. SnapShot: Lipid Droplets Cell. 139. PMID 19945384 DOI: 10.1016/j.cell.2009.11.023  0.8
2009 Farese RV, Walther TC. Lipid Droplets Finally Get a Little R-E-S-P-E-C-T Cell. 139: 855-860. PMID 19945371 DOI: 10.1016/j.cell.2009.11.005  0.8
2009 Koliwad SK, Kuo T, Shipp LE, Gray NE, Backhed F, So AY, Farese RV, Wang JC. Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism. The Journal of Biological Chemistry. 284: 25593-601. PMID 19628874 DOI: 10.1074/jbc.M109.025452  0.8
2009 Villanueva CJ, Monetti M, Shih M, Zhou P, Watkins SM, Bhanot S, Farese RV. Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids. Hepatology (Baltimore, Md.). 50: 434-42. PMID 19472314 DOI: 10.1002/hep.22980  0.8
2009 Yen CL, Cheong ML, Grueter C, Zhou P, Moriwaki J, Wong JS, Hubbard B, Marmor S, Farese RV. Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding. Nature Medicine. 15: 442-6. PMID 19287392 DOI: 10.1038/nm.1937  0.8
2009 Guo Y, Cordes KR, Farese RV, Walther TC. Lipid droplets at a glance Journal of Cell Science. 122: 749-752. PMID 19261844 DOI: 10.1242/jcs.037630  0.8
2009 Stone SJ, Levin MC, Zhou P, Han J, Walther TC, Farese RV. The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria. The Journal of Biological Chemistry. 284: 5352-61. PMID 19049983 DOI: 10.1074/jbc.M805768200  0.8
2009 Walther TC, Farese RV. The life of lipid droplets Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids. 1791: 459-466. PMID 19041421 DOI: 10.1016/j.bbalip.2008.10.009  0.8
2009 Shih MY, Kane MA, Zhou P, Yen CL, Streeper RS, Napoli JL, Farese RV. Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin. The Journal of Biological Chemistry. 284: 4292-9. PMID 19028692 DOI: 10.1074/jbc.M807503200  0.8
2008 Guo Y, Walther TC, Rao M, Stuurman N, Goshima G, Terayama K, Wong JS, Vale RD, Walter P, Farese RV. Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. Nature. 453: 657-61. PMID 18408709 DOI: 10.1038/nature06928  0.8
2007 Levin MC, Monetti M, Watt MJ, Sajan MP, Stevens RD, Bain JR, Newgard CB, Farese RV, Farese RV. Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle. American Journal of Physiology. Endocrinology and Metabolism. 293: E1772-81. PMID 17940217 DOI: 10.1152/ajpendo.00158.2007  0.32
2007 Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, ... ... Farese RV, et al. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Molecular and Cellular Biology. 27: 8807-14. PMID 17923681 DOI: 10.1128/MCB.01636-07  0.8
2007 Farese RV, Sajan MP, Yang H, Li P, Mastorides S, Gower WR, Nimal S, Choi CS, Kim S, Shulman GI, Kahn CR, Braun U, Leitges M. Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes. The Journal of Clinical Investigation. 117: 2289-301. PMID 17641777 DOI: 10.1172/JCI31408  0.32
2007 Monetti M, Levin MC, Watt MJ, Sajan MP, Marmor S, Hubbard BK, Stevens RD, Bain JR, Newgard CB, Farese RV, Hevener AL, Farese RV. Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metabolism. 6: 69-78. PMID 17618857 DOI: 10.1016/j.cmet.2007.05.005  0.32
2006 Stone SJ, Levin MC, Farese RV. Membrane topology and identification of key functional amino acid residues of murine Acyl-CoA:diacylglycerol acyltransferase-2 Journal of Biological Chemistry. 281: 40273-40282. PMID 17035227 DOI: 10.1074/jbc.M607986200  0.8
2006 Feldman BJ, Streeper RS, Farese RV, Yamamoto KR. Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects. Proceedings of the National Academy of Sciences of the United States of America. 103: 15675-80. PMID 17030820 DOI: 10.1073/pnas.0607501103  0.8
2006 Farese RV. The nine lives of ACAT inhibitors Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 1684-1686. PMID 16857957 DOI: 10.1161/01.ATV.0000227511.35456.90  0.8
2006 Rudel LL, Farese RV. ACAT inhibition and the progression of coronary atherosclerosis. The New England Journal of Medicine. 354: 2616-7; author reply. PMID 16775245 DOI: 10.1056/NEJMc061094  0.8
2006 Yen CLE, Farese RV. Fat breakdown: A function for CGI-58 (ABHD5) provides a new piece of the puzzle Cell Metabolism. 3: 305-307. PMID 16679288 DOI: 10.1016/j.cmet.2006.04.001  0.8
2005 Chen HC, Farese RV. Inhibition of triglyceride synthesis as a treatment strategy for obesity: Lessons from DGAT1-deficient mice Arteriosclerosis, Thrombosis, and Vascular Biology. 25: 482-486. PMID 15569818 DOI: 10.1161/01.ATV.0000151874.81059.ad  0.8
2005 Yen CLE, Monetti M, Burri BJ, Farese RV. The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters Journal of Lipid Research. 46: 1502-1511. DOI: 10.1194/jlr.M500036-JLR200  0.8
2004 Chen HC, Rao M, Sajan MP, Standaert M, Kanoh Y, Miura A, Farese RV. Role of adipocyte-derived factors in enhancing insulin signaling in skeletal muscle and white adipose tissue of mice lacking acyl CoA: diacylglycerol acyltransferase 1 Diabetes. 53: 1445-1451. PMID 15161747 DOI: 10.2337/diabetes.53.6.1445  0.8
2004 Standaert ML, Sajan MP, Miura A, Kanoh Y, Chen HC, Farese RV. Insulin-induced activation of atypical protein kinase C, but not protein kinase B, is maintained in diabetic (ob/ob and Goto-Kakazaki) liver: Contrasting insulin signaling patterns in liver versus muscle define phenotypes of type 2 diabetic and high fat-induced insulin-resistant states Journal of Biological Chemistry. 279: 24929-24934. PMID 15069067 DOI: 10.1074/jbc.M402440200  0.8
2003 Yen CLE, Farese RV. MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine Journal of Biological Chemistry. 278: 18532-18537. PMID 12621063 DOI: 10.1074/jbc.M301633200  0.8
2002 Chen HC, Ladha Z, Farese RV. Deficiency of Acyl coenzyme a:Diacylglycerol acyltransferase 1 increases leptin sensitivity in murine obesity models Endocrinology. 143: 2893-2898. PMID 12130553 DOI: 10.1210/en.143.8.2893  0.8
2002 Chen HC, Farese RV. Fatty acids, triglycerides, and glucose metabolism: Recent insights from knockout mice Current Opinion in Clinical Nutrition and Metabolic Care. 5: 359-363. PMID 12107369 DOI: 10.1097/00075197-200207000-00002  0.8
2002 Chen HC, Farese RV. Determination of adipocyte size by computer image analysis Journal of Lipid Research. 43: 986-989. PMID 12032175  0.8
2002 Chen HC, Bandyopadhyay G, Sajan MP, Kanoh Y, Standaert M, Farese RV. Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-β-D-riboside (AICAR)-stimulated glucose transport Journal of Biological Chemistry. 277: 23554-23562. PMID 11978788 DOI: 10.1074/jbc.M201152200  0.8
2001 Buhman KK, Chen HC, Farese RV. The Enzymes of Neutral Lipid Synthesis Journal of Biological Chemistry. 276: 40369-40372. PMID 11544264 DOI: 10.1074/jbc.R100050200  0.8
2000 Chen HC, Farese RV. DGAT and triglyceride synthesis: A new target for obesity treatment? Trends in Cardiovascular Medicine. 10: 188-192. PMID 11282293 DOI: 10.1016/S1050-1738(00)00066-9  0.8
2000 Buhman KF, Accad M, Farese RV. Mammalian acyl-CoA:cholesterol acyltransferases Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids. 1529: 142-154. PMID 11111084 DOI: 10.1016/S1388-1981(00)00144-X  0.8
2000 Farese RV, Cases S, Smith SJ. Triglyceride synthesis: Insights from the cloning of diacylglycerol acyltransferase Current Opinion in Lipidology. 11: 229-234. PMID 10882337 DOI: 10.1097/00041433-200006000-00002  0.8
1999 Chen HC, Farese RV. Steroid hormones: Interactions with membrane-bound receptors Current Biology. 9. PMID 10395533 DOI: 10.1016/S0960-9822(99)80300-5  0.8
1999 Herz J, Farese RV. The LDL receptor gene family, apolipoprotein B and cholesterol in embryonic development Journal of Nutrition. 129. PMID 10064312 DOI: 10.1093/jn/129.2.473S  0.8
1998 Accad M, Farese RV. Cholesterol homeostasis: A role for oxysterols Current Biology. 8. PMID 9742388  0.8
1998 Farese RV. Acyl CoA:cholesterol acyltransferase genes and knockout mice Current Opinion in Lipidology. 9: 119-123. PMID 9559268 DOI: 10.1097/00041433-199804000-00007  0.8
1998 Farese RV, Herz J. Cholesterol metabolism and embryogenesis Trends in Genetics. 14: 115-120. PMID 9540409 DOI: 10.1016/S0168-9525(97)01377-2  0.8
1997 Khovidhunkit W, Farese RV. Resolution of propylthiouracil-induced hepatic failure after treatment of thyrotoxicosis. The Western Journal of Medicine. 167: 353-6. PMID 9392993  0.8
1993 Linton MF, Farese RV, Young SG. Familial hypobetalipoproteinemia Journal of Lipid Research. 34: 521-541. PMID 8496659  0.8
1992 Farese RV, Linton MF, Young SG. Apolipoprotein B gene mutations affecting cholesterol levels Journal of Internal Medicine. 231: 643-652. PMID 1619387  0.8
1992 Farese RV, Flynn LM, Young SG. Modification of the apolipoprotein B gene in HepG2 cells by gene targeting Journal of Clinical Investigation. 90: 256-261. PMID 1321843  0.8
1991 Farese RV, Yost TJ, Eckel RH. Tissue-specific regulation of lipoprotein lipase activity by insulin/glucose in normal-weight humans Metabolism. 40: 214-216. PMID 1988780 DOI: 10.1016/0026-0495(91)90178-Y  0.8
1986 Trimble ER, Bruzzone R, Biden TJ, Farese RV. Secretin induces rapid increases in inositol trisphosphate, cytosolic Ca2+ and diacylglycerol as well as cyclic AMP in rat pancreatic acini Biochemical Journal. 239: 257-261. PMID 3028367  0.8
1983 Farese RV. Phosphoinositide metabolism and hormone action Endocrine Reviews. 4: 78-95. PMID 6131819  0.8
1971 Farese RV. On the requirement for calcium during the steroidogenic effect of ACTH Endocrinology. 89: 1057-1063. PMID 4398394  0.8
1971 Farese RV. Stimulation of pregnenolone synthesis by ACTH in rat adrenal sections Endocrinology. 89: 958-962. PMID 4328499  0.8
1971 Farese RV. Stimulatory effects of calcium on protein synthesis in adrenal (and thyroidal) cell-free systems as related to trophic hormone action Endocrinology. 89: 1064-1074. PMID 4328496  0.8
1970 Farese RV. Inhibition of cholesterol side chain cleavage by cyanoketone (2α-cyano-4,4,17α-trimethyl-17β-hydroxyandrost-5-en-3-one) Steroids. 15: 245-250. PMID 5459077 DOI: 10.1016/S0039-128X(70)80037-X  0.8
1970 Linarelli LG, Farese RV. The effects of imidazole on adrenal metabolism in vitro Pharmacology. 4: 33-38. PMID 4393463  0.8
1969 Glinsmann WH, Hern EP, Linarelli LG, Farese RV. Similarities between effects of adenosine 3',5'-monophosphate and guanosine 3' 5'-monophosphate on liver and adrenal metabolism Endocrinology. 85: 711-719. PMID 4389873  0.8
1969 Farese RV. Effects of ACTH and cyclic-AMP in vitro on incorporation of 3H-leucine and 14C-orotic acid into protein and RNA in the presence of an inhibitor of cholesterol side chain cleavage Endocrinology. 85: 1209-1212. PMID 4310490  0.8
1967 Farese RV. Adrenocorticotrophin-induced changes in the steroidogenic activity of adrenal cell-free preparations Biochemistry. 6: 2052-2065. PMID 4383053  0.8
1967 Farese RV, Schnure JJ. Effects of ACTH on adrenal RNA synthesis Endocrinology. 80: 872-882. PMID 4290300  0.8
1966 Farese RV. Effects of actinomycin D on ACTH-induced corticosteroidogenesis Endocrinology. 78: 929-936. PMID 4379923  0.8
1966 Farese RV. Early effects of ACTH on adrenal protein synthesis Endocrinology. 78: 125-136. PMID 4286050  0.8
1964 FARESE RV. CHANGES IN (14C)GLYCINE-INCORPORATING ACTIVITIES OF RAT-ADRENAL Biochimica Et Biophysica Acta. 91: 515-521. PMID 14254022  0.8
1964 FARESE RV. FURTHER STUDIES ON THE STIMULATION OF ADRENAL PROTEIN SYNTHESIS BY Endocrinology. 74: 579-585. PMID 14183203  0.8
1964 Farese RV. Inhibition of the steroidogenic effect of ACTH and incorporation of amino acid into rat adrenal protein in vitro by chloramphenicol Bba Specialized Section On Nucleic Acids and Related Subjects. 87: 699-701.  0.8
1964 Farese RV. Changes in [14C]glycine-incorporating activities of rat-adrenal microsomes and soluble cell fraction during prolonged adrenocorticotropin administration Bba Specialized Section On Nucleic Acids and Related Subjects. 91: 515-521.  0.8
1963 Farese RV, Reddy WJ. Observations on the interrelations between adrenal protein, RNA and DNA during prolonged ACTH administration Bba - Biochimica Et Biophysica Acta. 76: 145-148. PMID 14071610  0.8
1963 FARESE RV, REDDY WJ. EFFECT OF ADRENOCORTICOTROPHIN ON ADRENAL PROTEIN SYNTHESIS Endocrinology. 73: 294-303. PMID 14065106  0.8
1962 FARESE RV, PLAGER JE. The in vitro red blood cell uptake of C-14-cortisol; studies of plasma protein binding of cortisol in normal and abnormal states The Journal of Clinical Investigation. 41: 53-60. PMID 13891604  0.8
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