V Michael Holers - Publications

Affiliations: 
Molecular Biology University of Colorado Anschutz Medical Campus, Denver, Aurora, CO 
Area:
Immunology, Molecular Biology, Cell Biology

280 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Song YJ, Choi IA, Meylan F, Demoruelle MK, Farley T, Richard AC, Hawley E, Botson J, Hong YJ, Lee EY, Mian SR, Hamilton BC, Thiele GM, Mikuls TR, Gara N, ... ... Holers VM, et al. Circulating TNF-like protein 1A (TL1A) is elevated early in rheumatoid arthritis and depends on TNF. Arthritis Research & Therapy. 22: 106. PMID 32381123 DOI: 10.1186/s13075-020-02198-9  0.32
2020 Ayyappan P, Harms RZ, Seifert JA, Bemis EA, Feser ML, Deane KD, Demoruelle MK, Mikuls TR, Holers VM, Sarvetnick NE. Heightened Levels of Antimicrobial Response Factors in Patients With Rheumatoid Arthritis. Frontiers in Immunology. 11: 427. PMID 32265916 DOI: 10.3389/fimmu.2020.00427  0.32
2020 Holers VM, Borodovsky A, Scheinman RI, Ho N, Ramirez JR, Dobó J, Gál P, Lindenberger J, Hansen AG, Desai D, Pihl R, Thiel S, Banda NK. Key Components of the Complement Lectin Pathway Are Not Only Required for the Development of Inflammatory Arthritis but Also Regulate the Transcription of Factor D. Frontiers in Immunology. 11: 201. PMID 32153567 DOI: 10.3389/fimmu.2020.00201  0.4
2019 Frid MG, McKeon BA, Thurman JM, Maron BA, Li M, Zhang H, Kumar S, Sullivan T, Laskowsky J, Fini MA, Hu S, Tuder RM, Gandjeva A, Wilkins MR, Rhodes CJ, ... ... Holers VM, et al. Immunoglobulin-Driven Complement Activation Regulates Pro-Inflammatory Remodeling in Pulmonary Hypertension. American Journal of Respiratory and Critical Care Medicine. PMID 31545648 DOI: 10.1164/rccm.201903-0591OC  0.6
2019 Bemis EA, Norris JM, Seifert J, Frazer-Abel A, Okamoto Y, Feser ML, Demoruelle MK, Deane KD, Banda NK, Holers VM. Complement and its environmental determinants in the progression of human rheumatoid arthritis. Molecular Immunology. 112: 256-265. PMID 31207549 DOI: 10.1016/j.molimm.2019.05.012  0.32
2019 Deane KD, Holers VM. The Natural History of Rheumatoid Arthritis. Clinical Therapeutics. PMID 31196652 DOI: 10.1016/j.clinthera.2019.04.028  0.32
2019 Hernandez G, Mills TS, Rabe JL, Chavez JS, Kuldanek S, Kirkpatrick G, Noetzli L, Jubair WK, Zanche M, Meyers JR, Stevens BM, Fleenor CJ, Adane B, Dinarello CA, Ashton J, ... ... Holers VM, et al. Pro-inflammatory cytokine blockade attenuates myeloid expansion in a murine model of rheumatoid arthritis. Haematologica. PMID 31101752 DOI: 10.3324/haematol.2018.197210  0.6
2019 Berens HM, Polinski KJ, Mikuls TR, Khatter S, August J, Visser A, Mahler M, Weisman M, O'Dell JR, Keating RM, Buckner JH, Gregersen PK, Norris JM, Holers VM, Deane KD, et al. Anti-CCP3.1 and Anti-CCP-IgA Are Associated with Increasing Age in Individuals Without Rheumatoid Arthritis. The Journal of Rheumatology. PMID 30988128 DOI: 10.3899/jrheum.180897  0.32
2018 Banda NK, Desai D, Scheinman RI, Pihl R, Sekine H, Fujita T, Sharma V, Hansen AG, Garred P, Thiel S, Borodovsky A, Holers VM. Targeting of Liver Mannan-Binding Lectin-Associated Serine Protease-3 with RNA Interference Ameliorates Disease in a Mouse Model of Rheumatoid Arthritis. Immunohorizons. 2: 274-295. PMID 30417171 DOI: 10.4049/immunohorizons.1800053  0.4
2018 Jalal D, Renner B, Laskowski J, Stites E, Cooper J, Valente K, You Z, Perrenoud L, Le Quintrec M, Muhamed I, Christians U, Klawitter J, Lindorfer MA, Taylor RP, Holers VM, et al. Endothelial Microparticles and Systemic Complement Activation in Patients With Chronic Kidney Disease. Journal of the American Heart Association. 7. PMID 30006493 DOI: 10.1161/JAHA.117.007818  0.6
2018 Hughes-Austin JM, Deane KD, Giles JT, Derber LA, Zerbe GO, Dabelea DM, Sokolove J, Robinson WH, Holers VM, Norris JM. Plasma adiponectin levels are associated with circulating inflammatory cytokines in autoantibody positive first-degree relatives of rheumatoid arthritis patients. Plos One. 13: e0199578. PMID 29940013 DOI: 10.1371/journal.pone.0199578  0.6
2018 Verheul MK, Böhringer S, van Delft MAM, Jones JD, Rigby WFC, Gan RW, Holers VM, Edison JD, Deane KD, Janssen KMJ, Westra J, Brink M, Rantapää-Dahlqvist S, Huizinga TWJ, van der Helm-van Mil AHM, et al. The combination of three autoantibodies, ACPA, RF and anti-CarP antibodies is highly specific for rheumatoid arthritis: implications for very early identification of individuals at risk to develop rheumatoid arthritis. Arthritis & Rheumatology (Hoboken, N.J.). PMID 29781231 DOI: 10.1002/art.40562  0.32
2018 Okamoto T, Mathai SK, Hennessy CE, Hancock LA, Walts AD, Stefanski AL, Brown KK, Lynch DA, Cosgrove GP, Groshong SD, Cool CD, Schwarz MI, Banda NK, Thurman JM, Yang IV, ... Holers VM, et al. The relationship between complement C3 expression and the MUC5B genotype in pulmonary fibrosis. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 29565179 DOI: 10.1152/ajplung.00395.2017  0.6
2018 Goetz L, Laskowski J, Renner B, Pickering MC, Kulik L, Klawitter J, Stites E, Christians U, van der Vlag J, Ravichandran K, Holers VM, Thurman JM. Complement factor H protects mice from ischemic acute kidney injury but is not critical for controlling complement activation by glomerular IgM. European Journal of Immunology. PMID 29389016 DOI: 10.1002/eji.201747240  0.6
2018 Antonioli AH, White J, Crawford F, Renner B, Marchbank KJ, Hannan JP, Thurman JM, Marrack P, Holers VM. Modulation of the Alternative Pathway of Complement by Murine Factor H-Related Proteins. Journal of Immunology (Baltimore, Md. : 1950). 200: 316-326. PMID 29187587 DOI: 10.4049/jimmunol.1602017  0.6
2017 Demoruelle MK, Bowers E, Lahey LJ, Sokolove J, Purmalek M, Seto NL, Weisman MH, Norris JM, Kaplan MJ, Holers VM, William RH, Deane KD. Antibody Responses to Citrullinated and Non-Citrullinated Antigens in the Sputum of Subjects with and At-Risk for Rheumatoid Arthritis. Arthritis & Rheumatology (Hoboken, N.J.). PMID 29266801 DOI: 10.1002/art.40401  0.32
2017 Hughes-Austin JM, Gan RW, Deane KD, Weisman MH, Demoruelle MK, Sokolove J, Robinson WH, Holers VM, Norris JM, Ix JH. Association of Antibodies to Citrullinated Protein Antigens with Blood Pressure in First-Degree Relatives of Rheumatoid Arthritis Patients: The Studies of the Etiology of Rheumatoid Arthritis. American Journal of Nephrology. 46: 481-487. PMID 29237149 DOI: 10.1159/000485259  0.6
2017 Deane KD, Demoruelle MK, Kelmenson LB, Kuhn KA, Norris JM, Holers VM. Genetic and environmental risk factors for rheumatoid arthritis. Best Practice & Research. Clinical Rheumatology. 31: 3-18. PMID 29221595 DOI: 10.1016/j.berh.2017.08.003  0.6
2017 He YG, Pappworth IY, Rossbach A, Paulin J, Mavimba T, Hayes C, Kulik L, Holers VM, Knight AM, Marchbank KJ. A novel C3d-containing oligomeric vaccine provides insight into the viability of testing human C3d-based vaccines in mice. Immunobiology. PMID 29017821 DOI: 10.1016/j.imbio.2017.10.002  0.6
2017 Narang A, Qiao F, Atkinson C, Zhu H, Yang X, Kulik L, Holers VM, Tomlinson S. Natural IgM antibodies that bind neoepitopes exposed as a result of spinal cord injury , drive secondary injury by activating complement. Journal of Neuroinflammation. 14: 120. PMID 28629465 DOI: 10.1186/s12974-017-0894-6  1
2017 Demoruelle MK, Harrall KK, Ho L, Purmalek MM, Seto NL, Rothfuss HM, Weisman MH, Solomon JJ, Fischer A, Okamoto Y, Kelmenson LB, Parish MC, Feser M, Fleischer C, Anderson C, ... ... Holers VM, et al. Anti-citrullinated protein antibodies are associated with neutrophil extracellular traps in the sputum in relatives of rheumatoid arthritis patients. Arthritis & Rheumatology (Hoboken, N.J.). PMID 28182854 DOI: 10.1002/art.40066  0.32
2016 Hannan JP, Laskowski J, Thurman JM, Hageman GS, Holers VM. Mapping the Complement Factor H-Related Protein 1 (CFHR1):C3b/C3d Interactions. Plos One. 11: e0166200. PMID 27814381 DOI: 10.1371/journal.pone.0166200  0.6
2016 Chang HH, Liu GY, Dwivedi N, Sun B, Okamoto Y, Kinslow JD, Deane KD, Demoruelle MK, Norris JM, Thompson PR, Sparks JA, Rao DA, Karlson EW, Hung HC, Holers VM, et al. A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22. Jci Insight. 1: e90045. PMID 27777982 DOI: 10.1172/jci.insight.90045  0.32
2016 Banda NK, Acharya S, Scheinman RI, Mehta G, Coulombe M, Takahashi M, Sekine H, Thiel S, Fujita T, Holers VM. Mannan-Binding Lectin-Associated Serine Protease 1/3 Cleavage of Pro-Factor D into Factor D In Vivo and Attenuation of Collagen Antibody-Induced Arthritis through Their Targeted Inhibition by RNA Interference-Mediated Gene Silencing. Journal of Immunology (Baltimore, Md. : 1950). PMID 27707997 DOI: 10.4049/jimmunol.1600719  0.4
2016 Holers VM, Tomlinson S, Kulik L, Atkinson C, Rohrer B, Banda N, Thurman JM. New therapeutic and diagnostic opportunities for injured tissue-specific targeting of complement inhibitors and imaging modalities. Seminars in Immunology. PMID 27282113 DOI: 10.1016/j.smim.2016.05.007  1
2016 Kinslow JD, Blum LK, Deane KD, Demoruelle MK, Okamoto Y, Parish M, Kongpachith S, Lahey LJ, Norris JM, Robinson WH, Holers VM. IgA Plasmablasts are Elevated in Subjects At Risk for Future Rheumatoid Arthritis. Arthritis & Rheumatology (Hoboken, N.J.). PMID 27273876 DOI: 10.1002/art.39771  1
2016 Gan RW, Demoruelle MK, Deane KD, Weisman MH, Buckner JH, Gregersen PK, Mikuls TR, O'Dell JR, Keating RM, Fingerlin TE, Zerbe GO, Clare-Salzler MJ, Holers VM, Norris JM. Omega-3 fatty acids are associated with a lower prevalence of autoantibodies in shared epitope-positive subjects at risk for rheumatoid arthritis. Annals of the Rheumatic Diseases. PMID 27190099 DOI: 10.1136/annrheumdis-2016-209154  0.32
2016 Laskowski J, Renner B, Le Quintrec M, Panzer S, Hannan JP, Ljubanovic D, Ruseva MM, Borza DB, Antonioli AH, Pickering MC, Holers VM, Thurman JM. Distinct roles for the complement regulators factor H and Crry in protection of the kidney from injury. Kidney International. PMID 27165610 DOI: 10.1016/j.kint.2016.02.036  0.6
2015 Mackey RH, Kuller LH, Deane KD, Walitt BT, Chang YF, Holers VM, Robinson WH, Tracy RP, Hlatky MA, Eaton C, Liu S, Freiberg MS, Birru Talabi M, Schelbert EB, Moreland LW. Rheumatoid arthritis, anti-CCP positivity, and cardiovascular disease risk in the Women's Health Initiative. Arthritis & Rheumatology (Hoboken, N.J.). PMID 25988241 DOI: 10.1002/art.39198  0.6
2015 Holers VM. Targeting mechanisms at sites of complement activation for imaging and therapy. Immunobiology. PMID 25979851 DOI: 10.1016/j.imbio.2015.04.005  1
2015 Panzer SE, Laskowski J, Renner B, Kulik L, Ljubanovic D, Huber KM, Zhong W, Pickering MC, Holers VM, Thurman JM. IgM exacerbates glomerular disease progression in complement-induced glomerulopathy. Kidney International. PMID 25945405 DOI: 10.1038/ki.2015.120  0.6
2015 Atkinson C, Qiao F, Yang X, Zhu P, Reaves N, Kulik L, Goddard M, Holers VM, Tomlinson S. Targeting pathogenic postischemic self-recognition by natural IgM to protect against posttransplantation cardiac reperfusion injury. Circulation. 131: 1171-80. PMID 25825397 DOI: 10.1161/CIRCULATIONAHA.114.010482  1
2015 Cruickshank MN, Dods J, Taylor RL, Karimi M, Fenwick EJ, Quail EA, Rea AJ, Holers VM, Abraham LJ, Ulgiati D. Analysis of tandem E-box motifs within human Complement receptor 2 (CR2/CD21) promoter reveals cell specific roles for RP58, E2A, USF and localized chromatin accessibility. The International Journal of Biochemistry & Cell Biology. 64: 107-19. PMID 25817480 DOI: 10.1016/j.biocel.2015.03.016  0.4
2015 Gan RW, Trouw LA, Shi J, Toes RE, Huizinga TW, Demoruelle MK, Kolfenbach JR, Zerbe GO, Deane KD, Edison JD, Gilliland WR, Norris JM, Holers VM. Anti-carbamylated protein antibodies are present prior to rheumatoid arthritis and are associated with its future diagnosis. The Journal of Rheumatology. 42: 572-9. PMID 25593232 DOI: 10.3899/jrheum.140767  1
2015 Kulik L, Hewitt FB, Willis VC, Rodriguez R, Tomlinson S, Holers VM. A new mouse anti-mouse complement receptor type 2 and 1 (CR2/CR1) monoclonal antibody as a tool to study receptor involvement in chronic models of immune responses and disease. Molecular Immunology. 63: 479-88. PMID 25457881 DOI: 10.1016/j.molimm.2014.10.005  0.32
2015 Liang MH, Couto MC, Duarte CC, Gall V, White P, Naides S, Schumacher HR, Hwang AS, Holers VM, Deane KD, Gupta S, Ho IC, Finckh A, Kopec J, Choi CB, et al. An Internet-based technique for the identification of persons with symptoms of inflammatory polyarthritis of less than 12 weeks. Clinical Rheumatology. 34: 465-70. PMID 25339123 DOI: 10.1007/s10067-014-2796-7  0.32
2014 Yui J, Holers VM, Yang S, Wu HM, Cataland SR. Clinical utility of complement biomarkers in the diagnosis and treatment of acute thrombotic microangiopathies. British Journal of Haematology. 167: 697-8. PMID 25040791 DOI: 10.1111/bjh.13025  0.4
2014 Neher MD, Rich MC, Keene CN, Weckbach S, Bolden AL, Losacco JT, Patane J, Flierl MA, Kulik L, Holers VM, Stahel PF. Deficiency of complement receptors CR2/CR1 in Cr2⁻/⁻ mice reduces the extent of secondary brain damage after closed head injury. Journal of Neuroinflammation. 11: 95. PMID 24885042 DOI: 10.1186/1742-2094-11-95  0.6
2014 Cataland SR, Holers VM, Geyer S, Yang S, Wu HM. Biomarkers of terminal complement activation confirm the diagnosis of aHUS and differentiate aHUS from TTP. Blood. 123: 3733-8. PMID 24695849 DOI: 10.1182/blood-2013-12-547067  0.4
2014 Kuller LH, Mackey RH, Walitt BT, Deane KD, Holers VM, Robinson WH, Sokolove J, Chang Y, Liu S, Parks CG, Wright NC, Moreland LW. Determinants of mortality among postmenopausal women in the women's health initiative who report rheumatoid arthritis. Arthritis & Rheumatology (Hoboken, N.J.). 66: 497-507. PMID 24574208 DOI: 10.1002/art.38268  0.6
2014 Kuller LH, Mackey RH, Walitt BT, Deane KD, Holers VM, Robinson WH, Sokolove J, Chang Y, Moreland LW. Rheumatoid arthritis in the Women's Health Initiative: methods and baseline evaluation. American Journal of Epidemiology. 179: 917-26. PMID 24569640 DOI: 10.1093/aje/kwu003  0.6
2014 Young KA, Terrell DR, Guthridge JM, Kamen DL, Gilkeson GS, Karp DR, Ishimori ML, Weisman MH, Holers VM, Harley JB, Norris JM, James JA. Smoking is not associated with autoantibody production in systemic lupus erythematosus patients, unaffected first-degree relatives, nor healthy controls. Lupus. 23: 360-9. PMID 24449338 DOI: 10.1177/0961203314520838  0.32
2014 Demoruelle MK, Deane KD, Holers VM. When and where does inflammation begin in rheumatoid arthritis? Current Opinion in Rheumatology. 26: 64-71. PMID 24247116 DOI: 10.1097/BOR.0000000000000017  0.32
2014 Holers VM, Deane KD. Preclinical features of rheumatoid arthritis Rheumatology: Sixth Edition. 1: 698-703. DOI: 10.1016/B978-0-323-09138-1.00084-X  0.32
2013 Pickering MC, D'Agati VD, Nester CM, Smith RJ, Haas M, Appel GB, Alpers CE, Bajema IM, Bedrosian C, Braun M, Doyle M, Fakhouri F, Fervenza FC, Fogo AB, Frémeaux-Bacchi V, ... ... Holers VM, et al. C3 glomerulopathy: consensus report. Kidney International. 84: 1079-89. PMID 24172683 DOI: 10.1038/ki.2013.377  0.6
2013 Wu TC, Yang S, Haven S, Holers VM, Lundberg AS, Wu H, Cataland SR. Complement activation and mortality during an acute episode of thrombotic thrombocytopenic purpura. Journal of Thrombosis and Haemostasis : Jth. 11: 1925-7. PMID 23927533 DOI: 10.1111/jth.12369  0.4
2013 Willis VC, Demoruelle MK, Derber LA, Chartier-Logan CJ, Parish MC, Pedraza IF, Weisman MH, Norris JM, Holers VM, Deane KD. Sputum autoantibodies in patients with established rheumatoid arthritis and subjects at risk of future clinically apparent disease Arthritis and Rheumatism. 65: 2545-2554. PMID 23817979 DOI: 10.1002/art.38066  0.32
2013 Whitcup SM, Sodhi A, Atkinson JP, Holers VM, Sinha D, Rohrer B, Dick AD. The role of the immune response in age-related macular degeneration. International Journal of Inflammation. 2013: 348092. PMID 23762772 DOI: 10.1155/2013/348092  1
2013 Young KA, Deane KD, Derber LA, Hughes-Austin JM, Wagner CA, Sokolove J, Weisman MH, Buckner JH, Mikuls TR, O'Dell JR, Keating RM, Gregersen PK, Robinson WH, Holers VM, Norris JM. Relatives without rheumatoid arthritis show reactivity to anti-citrullinated protein/peptide antibodies that are associated with arthritis-related traits: studies of the etiology of rheumatoid arthritis. Arthritis and Rheumatism. 65: 1995-2004. PMID 23754702 DOI: 10.1002/art.38022  0.6
2013 Demoruelle MK, Parish MC, Derber LA, Kolfenbach JR, Hughes-Austin JM, Weisman MH, Gilliland W, Edison JD, Buckner JH, Mikuls TR, O'Dell JR, Keating RM, Gregersen PK, Norris JM, Holers VM, et al. Performance of anti-cyclic citrullinated Peptide assays differs in subjects at increased risk of rheumatoid arthritis and subjects with established disease. Arthritis and Rheumatism. 65: 2243-52. PMID 23686569 DOI: 10.1002/art.38017  0.32
2013 Arend WP, Mehta G, Antonioli AH, Takahashi M, Takahashi K, Stahl GL, Holers VM, Banda NK. Roles of adipocytes and fibroblasts in activation of the alternative pathway of complement in inflammatory arthritis in mice. Journal of Immunology (Baltimore, Md. : 1950). 190: 6423-33. PMID 23650618 DOI: 10.4049/jimmunol.1300580  0.6
2013 Thurman JM, Kulik L, Orth H, Wong M, Renner B, Sargsyan SA, Mitchell LM, Hourcade DE, Hannan JP, Kovacs JM, Coughlin B, Woodell AS, Pickering MC, Rohrer B, Holers VM. Detection of complement activation using monoclonal antibodies against C3d. The Journal of Clinical Investigation. 123: 2218-30. PMID 23619360 DOI: 10.1172/JCI65861  0.4
2013 Gan RW, Deane KD, Zerbe GO, Demoruelle MK, Weisman MH, Buckner JH, Gregersen PK, Mikuls TR, O'Dell JR, Keating RM, Holers VM, Norris JM. Relationship between air pollution and positivity of RA-related autoantibodies in individuals without established RA: a report on SERA. Annals of the Rheumatic Diseases. 72: 2002-5. PMID 23572338 DOI: 10.1136/annrheumdis-2012-202949  0.32
2013 Keith RC, Sokolove J, Edelman BL, Lahey L, Redente EF, Holers VM, Sakaguchi S, Robinson WH, Riches DW. Testosterone is protective in the sexually dimorphic development of arthritis and lung disease in SKG mice. Arthritis and Rheumatism. 65: 1487-93. PMID 23529475 DOI: 10.1002/art.37943  0.6
2013 Joseph K, Kulik L, Coughlin B, Kunchithapautham K, Bandyopadhyay M, Thiel S, Thielens NM, Holers VM, Rohrer B. Oxidative stress sensitizes retinal pigmented epithelial (RPE) cells to complement-mediated injury in a natural antibody-, lectin pathway-, and phospholipid epitope-dependent manner. The Journal of Biological Chemistry. 288: 12753-65. PMID 23493397 DOI: 10.1074/jbc.M112.421891  0.4
2013 Walitt B, Mackey R, Kuller L, Deane KD, Robinson W, Holers VM, Chang YF, Moreland L. Predictive value of autoantibody testing for validating self-reported diagnoses of rheumatoid arthritis in the Women's Health Initiative. American Journal of Epidemiology. 177: 887-93. PMID 23492764 DOI: 10.1093/aje/kws310  0.32
2013 Banda NK, Mehta G, Ferreira VP, Cortes C, Pickering MC, Pangburn MK, Arend WP, Holers VM. Essential role of surface-bound complement factor H in controlling immune complex-induced arthritis. Journal of Immunology (Baltimore, Md. : 1950). 190: 3560-9. PMID 23436934 DOI: 10.4049/jimmunol.1203271  1
2013 Holers VM, Rohrer B, Tomlinson S. CR2-mediated targeting of complement inhibitors: bench-to-bedside using a novel strategy for site-specific complement modulation. Advances in Experimental Medicine and Biology. 735: 137-54. PMID 23402024 DOI: 10.1007/978-1-4614-4118-2_9  1
2013 Strassheim D, Renner B, Panzer S, Fuquay R, Kulik L, Ljubanović D, Holers VM, Thurman JM. IgM contributes to glomerular injury in FSGS. Journal of the American Society of Nephrology : Jasn. 24: 393-406. PMID 23393315 DOI: 10.1681/ASN.2012020187  1
2013 Hu X, Holers VM, Thurman JM, Schoeb TR, Ramos TN, Barnum SR. Therapeutic inhibition of the alternative complement pathway attenuates chronic EAE. Molecular Immunology. 54: 302-8. PMID 23337717 DOI: 10.1016/j.molimm.2012.12.018  1
2013 Cordova KN, Willis VC, Haskins K, Holers VM. A citrullinated fibrinogen-specific T cell line enhances autoimmune arthritis in a mouse model of rheumatoid arthritis. Journal of Immunology (Baltimore, Md. : 1950). 190: 1457-65. PMID 23319740 DOI: 10.4049/jimmunol.1201517  1
2013 Liubchenko GA, Appleberry HC, Striebich CC, Franklin KE, Derber LA, Holers VM, Lyubchenko T. Rheumatoid arthritis is associated with signaling alterations in naturally occurring autoreactive B-lymphocytes. Journal of Autoimmunity. 40: 111-21. PMID 23058039 DOI: 10.1016/j.jaut.2012.09.001  1
2013 Hughes-Austin JM, Deane KD, Derber LA, Kolfenbach JR, Zerbe GO, Sokolove J, Lahey LJ, Weisman MH, Buckner JH, Mikuls TR, O'Dell JR, Keating RM, Gregersen PK, Robinson WH, Holers VM, et al. Multiple cytokines and chemokines are associated with rheumatoid arthritis-related autoimmunity in first-degree relatives without rheumatoid arthritis: Studies of the Aetiology of Rheumatoid Arthritis (SERA). Annals of the Rheumatic Diseases. 72: 901-7. PMID 22915618 DOI: 10.1136/annrheumdis-2012-201505  1
2013 Asokan R, Banda NK, Szakonyi G, Chen XS, Holers VM. Human complement receptor 2 (CR2/CD21) as a receptor for DNA: implications for its roles in the immune response and the pathogenesis of systemic lupus erythematosus (SLE). Molecular Immunology. 53: 99-110. PMID 22885687 DOI: 10.1016/j.molimm.2012.07.002  1
2013 Lambris JD, Holers VM, Ricklin D. Preface Advances in Experimental Medicine and Biology. 734.  1
2012 Mikuls TR, Thiele GM, Deane KD, Payne JB, O'Dell JR, Yu F, Sayles H, Weisman MH, Gregersen PK, Buckner JH, Keating RM, Derber LA, Robinson WH, Holers VM, Norris JM. Porphyromonas gingivalis and disease-related autoantibodies in individuals at increased risk of rheumatoid arthritis. Arthritis and Rheumatism. 64: 3522-30. PMID 22736291 DOI: 10.1002/art.34595  1
2012 Sokolove J, Bromberg R, Deane KD, Lahey LJ, Derber LA, Chandra PE, Edison JD, Gilliland WR, Tibshirani RJ, Norris JM, Holers VM, Robinson WH. Autoantibody epitope spreading in the pre-clinical phase predicts progression to rheumatoid arthritis. Plos One. 7: e35296. PMID 22662108 DOI: 10.1371/journal.pone.0035296  0.6
2012 Thurman JM, Tchepeleva SN, Haas M, Panzer S, Boackle SA, Glogowska MJ, Quigg RJ, Holers VM. Complement alternative pathway activation in the autologous phase of nephrotoxic serum nephritis. American Journal of Physiology. Renal Physiology. 302: F1529-36. PMID 22492944 DOI: 10.1152/ajprenal.00422.2011  0.6
2012 Weckbach S, Neher M, Losacco JT, Bolden AL, Kulik L, Flierl MA, Bell SE, Holers VM, Stahel PF. Challenging the role of adaptive immunity in neurotrauma: Rag1(-/-) mice lacking mature B and T cells do not show neuroprotection after closed head injury. Journal of Neurotrauma. 29: 1233-42. PMID 22335783 DOI: 10.1089/neu.2011.2169  0.6
2012 Rohrer B, Coughlin B, Bandyopadhyay M, Holers VM. Systemic human CR2-targeted complement alternative pathway inhibitor ameliorates mouse laser-induced choroidal neovascularization. Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association For Ocular Pharmacology and Therapeutics. 28: 402-9. PMID 22309197 DOI: 10.1089/jop.2011.0212  1
2012 Banda NK, Hyatt S, Antonioli AH, White JT, Glogowska M, Takahashi K, Merkel TJ, Stahl GL, Mueller-Ortiz S, Wetsel R, Arend WP, Holers VM. Role of C3a receptors, C5a receptors, and complement protein C6 deficiency in collagen antibody-induced arthritis in mice. Journal of Immunology (Baltimore, Md. : 1950). 188: 1469-78. PMID 22205026 DOI: 10.4049/jimmunol.1102310  1
2012 Elvington A, Atkinson C, Kulik L, Zhu H, Yu J, Kindy MS, Holers VM, Tomlinson S. Pathogenic natural antibodies propagate cerebral injury following ischemic stroke in mice. Journal of Immunology (Baltimore, Md. : 1950). 188: 1460-8. PMID 22198950 DOI: 10.4049/jimmunol.1102132  1
2012 Keith RC, Powers JL, Redente EF, Sergew A, Martin RJ, Gizinski A, Holers VM, Sakaguchi S, Riches DW. A novel model of rheumatoid arthritis-associated interstitial lung disease in SKG mice. Experimental Lung Research. 38: 55-66. PMID 22185348 DOI: 10.3109/01902148.2011.636139  1
2012 Demoruelle MK, Weisman MH, Simonian PL, Lynch DA, Sachs PB, Pedraza IF, Harrington AR, Kolfenbach JR, Striebich CC, Pham QN, Strickland CD, Petersen BD, Parish MC, Derber LA, Norris JM, ... Holers VM, et al. Brief report: airways abnormalities and rheumatoid arthritis-related autoantibodies in subjects without arthritis: early injury or initiating site of autoimmunity? Arthritis and Rheumatism. 64: 1756-61. PMID 22183986 DOI: 10.1002/art.34344  1
2012 Takeda K, Thurman JM, Tomlinson S, Okamoto M, Shiraishi Y, Ferreira VP, Cortes C, Pangburn MK, Holers VM, Gelfand EW. The critical role of complement alternative pathway regulator factor H in allergen-induced airway hyperresponsiveness and inflammation. Journal of Immunology (Baltimore, Md. : 1950). 188: 661-7. PMID 22174452 DOI: 10.4049/jimmunol.1101813  1
2011 Wang Q, Rozelle AL, Lepus CM, Scanzello CR, Song JJ, Larsen DM, Crish JF, Bebek G, Ritter SY, Lindstrom TM, Hwang I, Wong HH, Punzi L, Encarnacion A, Shamloo M, ... ... Holers VM, et al. Identification of a central role for complement in osteoarthritis. Nature Medicine. 17: 1674-9. PMID 22057346 DOI: 10.1038/nm.2543  0.4
2011 Khan MA, Jiang X, Dhillon G, Beilke J, Holers VM, Atkinson C, Tomlinson S, Nicolls MR. CD4+ T cells and complement independently mediate graft ischemia in the rejection of mouse orthotopic tracheal transplants. Circulation Research. 109: 1290-301. PMID 21998328 DOI: 10.1161/CIRCRESAHA.111.250167  1
2011 Banda NK, Takahashi M, Takahashi K, Stahl GL, Hyatt S, Glogowska M, Wiles TA, Endo Y, Fujita T, Holers VM, Arend WP. Mechanisms of mannose-binding lectin-associated serine proteases-1/3 activation of the alternative pathway of complement. Molecular Immunology. 49: 281-9. PMID 21943708 DOI: 10.1016/j.molimm.2011.08.021  0.32
2011 Renner B, Ferreira VP, Cortes C, Goldberg R, Ljubanovic D, Pangburn MK, Pickering MC, Tomlinson S, Holland-Neidermyer A, Strassheim D, Holers VM, Thurman JM. Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury. Kidney International. 80: 165-73. PMID 21544060 DOI: 10.1038/ki.2011.115  1
2011 Willis VC, Gizinski AM, Banda NK, Causey CP, Knuckley B, Cordova KN, Luo Y, Levitt B, Glogowska M, Chandra P, Kulik L, Robinson WH, Arend WP, Thompson PR, Holers VM. N-α-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis. Journal of Immunology (Baltimore, Md. : 1950). 186: 4396-404. PMID 21346230 DOI: 10.4049/jimmunol.1001620  0.6
2011 Kulik L, Chen K, Huber BT, Holers VM. Human complement receptor type 2 (CR2/CD21) transgenic mice provide an in vivo model to study immunoregulatory effects of receptor antagonists. Molecular Immunology. 48: 883-94. PMID 21269698 DOI: 10.1016/j.molimm.2010.12.019  1
2011 Rohrer B, Coughlin B, Kunchithapautham K, Long Q, Tomlinson S, Takahashi K, Holers VM. The alternative pathway is required, but not alone sufficient, for retinal pathology in mouse laser-induced choroidal neovascularization. Molecular Immunology. 48: e1-8. PMID 21257205 DOI: 10.1016/j.molimm.2010.12.016  1
2011 Navarra SV, Ishimori MI, Uy EA, Hamijoyo L, Sama J, James JA, Holers VM, Weisman MH. Studies of Filipino patients with systemic lupus erythematosus: autoantibody profile of first-degree relatives. Lupus. 20: 537-43. PMID 21183559 DOI: 10.1177/0961203310385164  1
2011 Lynch AM, Gibbs RS, Murphy JR, Giclas PC, Salmon JE, Holers VM. Early elevations of the complement activation fragment C3a and adverse pregnancy outcomes. Obstetrics and Gynecology. 117: 75-83. PMID 21173647 DOI: 10.1097/AOG.0b013e3181fc3afa  1
2011 Karp DR, Holers VM. Complement in Health and Disease Goldman's Cecil Medicine: Twenty Fourth Edition. 1: 239-244. DOI: 10.1016/B978-1-4377-1604-7.00049-X  0.4
2010 Edelhauser HF, Rowe-Rendleman CL, Robinson MR, Dawson DG, Chader GJ, Grossniklaus HE, Rittenhouse KD, Wilson CG, Weber DA, Kuppermann BD, Csaky KG, Olsen TW, Kompella UB, Holers VM, Hageman GS, et al. Ophthalmic drug delivery systems for the treatment of retinal diseases: basic research to clinical applications. Investigative Ophthalmology & Visual Science. 51: 5403-20. PMID 20980702 DOI: 10.1167/iovs.10-5392  1
2010 Shaw CD, Storek MJ, Young KA, Kovacs JM, Thurman JM, Holers VM, Hannan JP. Delineation of the complement receptor type 2-C3d complex by site-directed mutagenesis and molecular docking. Journal of Molecular Biology. 404: 697-710. PMID 20951140 DOI: 10.1016/j.jmb.2010.10.005  1
2010 Banda NK, Takahashi M, Levitt B, Glogowska M, Nicholas J, Takahashi K, Stahl GL, Fujita T, Arend WP, Holers VM. Essential role of complement mannose-binding lectin-associated serine proteases-1/3 in the murine collagen antibody-induced model of inflammatory arthritis. Journal of Immunology (Baltimore, Md. : 1950). 185: 5598-606. PMID 20870940 DOI: 10.4049/jimmunol.1001564  0.6
2010 Renner B, Strassheim D, Amura CR, Kulik L, Ljubanovic D, Glogowska MJ, Takahashi K, Carroll MC, Holers VM, Thurman JM. B cell subsets contribute to renal injury and renal protection after ischemia/reperfusion. Journal of Immunology (Baltimore, Md. : 1950). 185: 4393-400. PMID 20810984 DOI: 10.4049/jimmunol.0903239  0.6
2010 Rohrer B, Long Q, Coughlin B, Renner B, Huang Y, Kunchithapautham K, Ferreira VP, Pangburn MK, Gilkeson GS, Thurman JM, Tomlinson S, Holers VM. A targeted inhibitor of the complement alternative pathway reduces RPE injury and angiogenesis in models of age-related macular degeneration. Advances in Experimental Medicine and Biology. 703: 137-49. PMID 20711712 DOI: 10.1007/978-1-4419-5635-4_10  1
2010 Renner B, Coleman K, Goldberg R, Amura C, Holland-Neidermyer A, Pierce K, Orth HN, Molina H, Ferreira VP, Cortes C, Pangburn MK, Holers VM, Thurman JM. The complement inhibitors Crry and factor H are critical for preventing autologous complement activation on renal tubular epithelial cells. Journal of Immunology (Baltimore, Md. : 1950). 185: 3086-94. PMID 20675597 DOI: 10.4049/jimmunol.1000111  0.6
2010 Deane KD, O'Donnell CI, Hueber W, Majka DS, Lazar AA, Derber LA, Gilliland WR, Edison JD, Norris JM, Robinson WH, Holers VM. The number of elevated cytokines and chemokines in preclinical seropositive rheumatoid arthritis predicts time to diagnosis in an age-dependent manner. Arthritis and Rheumatism. 62: 3161-72. PMID 20597112 DOI: 10.1002/art.27638  0.6
2010 Kovacs JM, Hannan JP, Eisenmesser EZ, Holers VM. Biophysical investigations of complement receptor 2 (CD21 and CR2)-ligand interactions reveal amino acid contacts unique to each receptor-ligand pair. The Journal of Biological Chemistry. 285: 27251-8. PMID 20558730 DOI: 10.1074/jbc.M110.106617  1
2010 Tan W, Wu H, Zhao J, Derber LA, Lee DM, Shadick NA, Conn DL, Smith EA, Gersuk VH, Nepom GT, Moreland LW, Furst DE, Thompson SD, Jonas BL, Holers VM, et al. A functional RANKL polymorphism associated with younger age at onset of rheumatoid arthritis. Arthritis and Rheumatism. 62: 2864-75. PMID 20533289 DOI: 10.1002/art.27589  1
2010 Deane KD, Norris JM, Holers VM. Preclinical rheumatoid arthritis: identification, evaluation, and future directions for investigation. Rheumatic Diseases Clinics of North America. 36: 213-41. PMID 20510231 DOI: 10.1016/j.rdc.2010.02.001  1
2010 Ercan A, Cui J, Chatterton DE, Deane KD, Hazen MM, Brintnell W, O'Donnell CI, Derber LA, Weinblatt ME, Shadick NA, Bell DA, Cairns E, Solomon DH, Holers VM, Rudd PM, et al. Aberrant IgG galactosylation precedes disease onset, correlates with disease activity, and is prevalent in autoantibodies in rheumatoid arthritis. Arthritis and Rheumatism. 62: 2239-48. PMID 20506563 DOI: 10.1002/art.27533  1
2010 Kolfenbach JR, Deane KD, Derber LA, O'Donnell CI, Gilliland WR, Edison JD, Rosen A, Darrah E, Norris JM, Holers VM. Autoimmunity to peptidyl arginine deiminase type 4 precedes clinical onset of rheumatoid arthritis. Arthritis and Rheumatism. 62: 2633-9. PMID 20496417 DOI: 10.1002/art.27570  0.32
2010 Serkova NJ, Renner B, Larsen BA, Stoldt CR, Hasebroock KM, Bradshaw-Pierce EL, Holers VM, Thurman JM. Renal inflammation: targeted iron oxide nanoparticles for molecular MR imaging in mice. Radiology. 255: 517-26. PMID 20332377 DOI: 10.1148/radiol.09091134  1
2010 Thurman JM, Renner B, Kunchithapautham K, Holers VM, Rohrer B. Aseptic injury to epithelial cells alters cell surface complement regulation in a tissue specific fashion. Advances in Experimental Medicine and Biology. 664: 151-8. PMID 20238013 DOI: 10.1007/978-1-4419-1399-9_18  1
2010 Quan TE, Roman RM, Rudenga BJ, Holers VM, Craft JE. Epstein-Barr virus promotes interferon-alpha production by plasmacytoid dendritic cells. Arthritis and Rheumatism. 62: 1693-701. PMID 20178121 DOI: 10.1002/art.27408  1
2010 Briggs FB, Ramsay PP, Madden E, Norris JM, Holers VM, Mikuls TR, Sokka T, Seldin MF, Gregersen PK, Criswell LA, Barcellos LF. Supervised machine learning and logistic regression identifies novel epistatic risk factors with PTPN22 for rheumatoid arthritis. Genes and Immunity. 11: 199-208. PMID 20090771 DOI: 10.1038/gene.2009.110  1
2010 Lynch AM, Murphy JR, Gibbs RS, Levine RJ, Giclas PC, Salmon JE, Holers VM. The interrelationship of complement-activation fragments and angiogenesis-related factors in early pregnancy and their association with pre-eclampsia. Bjog : An International Journal of Obstetrics and Gynaecology. 117: 456-62. PMID 20074261 DOI: 10.1111/j.1471-0528.2009.02473.x  1
2010 Banda NK, Levitt B, Wood AK, Takahashi K, Stahl GL, Holers VM, Arend WP. Complement activation pathways in murine immune complex-induced arthritis and in C3a and C5a generation in vitro. Clinical and Experimental Immunology. 159: 100-8. PMID 19843088 DOI: 10.1111/j.1365-2249.2009.04035.x  1
2009 Kolfenbach JR, Deane KD, Derber LA, O'Donnell C, Weisman MH, Buckner JH, Gersuk VH, Wei S, Mikuls TR, O'Dell J, Gregersen PK, Keating RM, Norris JM, Holers VM. A prospective approach to investigating the natural history of preclinical rheumatoid arthritis (RA) using first-degree relatives of probands with RA. Arthritis and Rheumatism. 61: 1735-42. PMID 19950324 DOI: 10.1002/art.24833  0.32
2009 Deane KD, Striebich CC, Goldstein BL, Derber LA, Parish MC, Feser ML, Hamburger EM, Brake S, Belz C, Goddard J, Norris JM, Karlson EW, Holers VM. Identification of undiagnosed inflammatory arthritis in a community health fair screen. Arthritis and Rheumatism. 61: 1642-9. PMID 19950306 DOI: 10.1002/art.24834  1
2009 Banda NK, Levitt B, Glogowska MJ, Thurman JM, Takahashi K, Stahl GL, Tomlinson S, Arend WP, Holers VM. Targeted inhibition of the complement alternative pathway with complement receptor 2 and factor H attenuates collagen antibody-induced arthritis in mice. Journal of Immunology (Baltimore, Md. : 1950). 183: 5928-37. PMID 19828624 DOI: 10.4049/jimmunol.0901826  1
2009 Thurman JM, Marians R, Emlen W, Wood S, Smith C, Akana H, Holers VM, Lesser M, Kline M, Hoffman C, Christen E, Trachtman H. Alternative pathway of complement in children with diarrhea-associated hemolytic uremic syndrome. Clinical Journal of the American Society of Nephrology : Cjasn. 4: 1920-4. PMID 19820137 DOI: 10.2215/CJN.02730409  1
2009 Xu X, Hsu HC, Chen J, Grizzle WE, Chatham WW, Stockard CR, Wu Q, Yang PA, Holers VM, Mountz JD. Increased expression of activation-induced cytidine deaminase is associated with anti-CCP and rheumatoid factor in rheumatoid arthritis. Scandinavian Journal of Immunology. 70: 309-16. PMID 19703021 DOI: 10.1111/j.1365-3083.2009.02302.x  1
2009 Ricklin D, Tzekou A, Garcia BL, Hammel M, McWhorter WJ, Sfyroera G, Wu YQ, Holers VM, Herbert AP, Barlow PN, Geisbrecht BV, Lambris JD. A molecular insight into complement evasion by the staphylococcal complement inhibitor protein family. Journal of Immunology (Baltimore, Md. : 1950). 183: 2565-74. PMID 19625656 DOI: 10.4049/jimmunol.0901443  1
2009 Gregersen PK, Amos CI, Lee AT, Lu Y, Remmers EF, Kastner DL, Seldin MF, Criswell LA, Plenge RM, Holers VM, Mikuls TR, Sokka T, Moreland LW, Bridges SL, Xie G, et al. REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis. Nature Genetics. 41: 820-3. PMID 19503088 DOI: 10.1038/ng.395  1
2009 Thurman JM, Renner B, Kunchithapautham K, Ferreira VP, Pangburn MK, Ablonczy Z, Tomlinson S, Holers VM, Rohrer B. Oxidative stress renders retinal pigment epithelial cells susceptible to complement-mediated injury. The Journal of Biological Chemistry. 284: 16939-47. PMID 19386604 DOI: 10.1074/jbc.M808166200  1
2009 Kulik L, Fleming SD, Moratz C, Reuter JW, Novikov A, Chen K, Andrews KA, Markaryan A, Quigg RJ, Silverman GJ, Tsokos GC, Holers VM. Pathogenic natural antibodies recognizing annexin IV are required to develop intestinal ischemia-reperfusion injury. Journal of Immunology (Baltimore, Md. : 1950). 182: 5363-73. PMID 19380783 DOI: 10.4049/jimmunol.0803980  1
2009 Twohig JP, Pappworth IY, Sivasankar B, Kulik L, Bull M, Holers VM, Wang EC, Marchbank KJ. Defective B cell ontogeny and humoral immune response in mice prematurely expressing human complement receptor 2 (CR2, CD21) is similar to that seen in aging wild type mice. Molecular Immunology. 46: 2002-13. PMID 19359041 DOI: 10.1016/j.molimm.2009.03.007  1
2009 Feser M, Derber LA, Deane KD, Lezotte DC, Weisman MH, Buckner JH, Mikuls T, O'Dell J, Gregersen PK, Holers VM, Norris JM. Plasma 25,OH vitamin D concentrations are not associated with rheumatoid arthritis (RA)-related autoantibodies in individuals at elevated risk for RA. The Journal of Rheumatology. 36: 943-6. PMID 19286844 DOI: 10.3899/jrheum.080764  0.32
2009 Gizinski AM, Mascolo M, Loucks JL, Kervitsky A, Meehan RT, Brown KK, Holers VM, Deane KD. Rheumatoid arthritis (RA)-specific autoantibodies in patients with interstitial lung disease and absence of clinically apparent articular RA. Clinical Rheumatology. 28: 611-3. PMID 19252818 DOI: 10.1007/s10067-009-1128-9  1
2009 Pappworth IY, Kulik L, Haluszczak C, Reuter JW, Holers VM, Marchbank KJ. Increased B cell deletion and significantly reduced auto-antibody titre due to premature expression of human complement receptor 2 (CR2, CD21). Molecular Immunology. 46: 1042-9. PMID 19187965 DOI: 10.1016/j.molimm.2008.08.273  1
2009 Kovacs JM, Hannan JP, Eisenmesser EZ, Holers VM. Mapping of the C3d ligand binding site on complement receptor 2 (CR2/CD21) using nuclear magnetic resonance and chemical shift analysis. The Journal of Biological Chemistry. 284: 9513-20. PMID 19164292 DOI: 10.1074/jbc.M808404200  1
2009 Lyubchenko T, Nielsen JP, Miller SM, Liubchenko GA, Holers VM. Role of initial protein phosphorylation events and localized release-activated calcium influx in B cell antigen receptor signaling Journal of Leukocyte Biology. 85: 298-309. PMID 19028960 DOI: 10.1189/jlb.0308193  1
2009 Mikuls TR, Payne JB, Reinhardt RA, Thiele GM, Maziarz E, Cannella AC, Holers VM, Kuhn KA, O'Dell JR. Antibody responses to Porphyromonas gingivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis. International Immunopharmacology. 9: 38-42. PMID 18848647 DOI: 10.1016/j.intimp.2008.09.008  1
2009 Huang Y, Qiao F, Atkinson C, Holers VM, Tomlinson S. A novel targeted inhibitor of the alternative pathway of complement and its therapeutic application in ischemia/reperfusion injury Journal of Immunology. 181: 8068-8076.  1
2008 Huang Y, Qiao F, Atkinson C, Holers VM, Tomlinson S. A novel targeted inhibitor of the alternative pathway of complement and its therapeutic application in ischemia/reperfusion injury. Journal of Immunology (Baltimore, Md. : 1950). 181: 8068-76. PMID 19017999  1
2008 Banda NK, Wood AK, Takahashi K, Levitt B, Rudd PM, Royle L, Abrahams JL, Stahl GL, Holers VM, Arend WP. Initiation of the alternative pathway of murine complement by immune complexes is dependent on N-glycans in IgG antibodies Arthritis and Rheumatism. 58: 3081-3089. PMID 18821684 DOI: 10.1002/art.23865  1
2008 Li K, Okemefuna AI, Gor J, Hannan JP, Asokan R, Holers VM, Perkins SJ. Solution Structure of the Complex Formed between Human Complement C3d and Full-length Complement Receptor Type 2 Journal of Molecular Biology. 384: 137-150. PMID 18804116 DOI: 10.1016/j.jmb.2008.08.084  1
2008 Young KA, Herbert AP, Barlow PN, Holers VM, Hannan JP. Molecular basis of the interaction between complement receptor type 2 (CR2/CD21) and Epstein-Barr virus glycoprotein gp350. Journal of Virology. 82: 11217-27. PMID 18786993 DOI: 10.1128/JVI.01673-08  1
2008 Holers VM. The spectrum of complement alternative pathway-mediated diseases Immunological Reviews. 223: 300-316. PMID 18613844 DOI: 10.1111/j.1600-065X.2008.00641.x  1
2008 Kuhn KA, Cozine CL, Tomooka B, Robinson WH, Holers VM. Complement receptor CR2/CR1 deficiency protects mice from collagen-induced arthritis and associates with reduced autoantibodies to type II collagen and citrullinated antigens. Molecular Immunology. 45: 2808-19. PMID 18374982 DOI: 10.1016/j.molimm.2008.01.036  1
2008 Lynch AM, Murphy JR, Byers T, Gibbs RS, Neville MC, Giclas PC, Salmon JE, Holers VM. Alternative complement pathway activation fragment Bb in early pregnancy as a predictor of preeclampsia. American Journal of Obstetrics and Gynecology. 198: 385.e1-9. PMID 18221926 DOI: 10.1016/j.ajog.2007.10.793  1
2008 Majka DS, Deane KD, Parrish LA, Lazar AA, Barón AE, Walker CW, Rubertone MV, Gilliland WR, Norris JM, Holers VM. Duration of preclinical rheumatoid arthritis-related autoantibody positivity increases in subjects with older age at time of disease diagnosis. Annals of the Rheumatic Diseases. 67: 801-7. PMID 17974596 DOI: 10.1136/ard.2007.076679  0.32
2007 Song H, Qiao F, Atkinson C, Holers VM, Tomlinson S. A complement C3 inhibitor specifically targeted to sites of complement activation effectively ameliorates collagen-induced arthritis in DBA/1J mice. Journal of Immunology (Baltimore, Md. : 1950). 179: 7860-7. PMID 18025232  1
2007 Young KA, Chen XS, Holers VM, Hannan JP. Isolating the Epstein-Barr virus gp350/220 binding site on complement receptor type 2 (CR2/CD21). The Journal of Biological Chemistry. 282: 36614-25. PMID 17925391 DOI: 10.1074/jbc.M706324200  1
2007 Holers VM. Antibodies to citrullinated proteins: Pathogenic and diagnostic significance Current Rheumatology Reports. 9: 396-400. PMID 17915095 DOI: 10.1007/s11926-007-0063-5  1
2007 Banda NK, Takahashi K, Wood AK, Holers VM, Arend WP. Pathogenic complement activation in collagen antibody-induced arthritis in mice requires amplification by the alternative pathway Journal of Immunology. 179: 4101-4109. PMID 17785849  1
2007 Lyubchenko T, Dal Porto JM, Holers VM, Cambier JC. Cutting edge: Complement (C3d)-linked antigens break B cell anergy Journal of Immunology. 179: 2695-2699. PMID 17709481  1
2007 Lenderink AM, Liegel K, Ljubanović D, Coleman KE, Gilkeson GS, Holers VM, Thurman JM. The alternative pathway of complement is activated in the glomeruli and tubulointerstitium of mice with adriamycin nephropathy American Journal of Physiology - Renal Physiology. 293. PMID 17522263 DOI: 10.1152/ajprenal.00403.2006  1
2007 Ho J, Moir S, Kulik L, Malaspina A, Donoghue ET, Miller NJ, Wang W, Chun TW, Fauci AS, Holers VM. Role for CD21 in the establishment of an extracellular HIV reservoir in lymphoid tissues. Journal of Immunology (Baltimore, Md. : 1950). 178: 6968-74. PMID 17513746 DOI: 10.4049/jimmunol.178.11.6968  1
2007 Mihai S, Chiriac MT, Takahashi K, Thurman JM, Holers VM, Zillikens D, Botto M, Sitaru C. The alternative pathway of complement activation is critical for blister induction in experimental epidermolysis bullosa acquisita Journal of Immunology. 178: 6514-6521. PMID 17475881  1
2007 Twohig J, Kulik L, Haluszczak C, Reuter J, Rossbach A, Bull M, Holers VM, Marchbank KJ. Defective B cell ontogeny and immune response in human complement receptor 2 (CR2, CD21) transgenic mice is partially recovered in the absence of C3. Molecular Immunology. 44: 3434-44. PMID 17379312 DOI: 10.1016/j.molimm.2007.02.011  1
2007 Looney RJ, Diamond B, Holers VM, Levesque MC, Moreland L, Nahm MH, St Clair EW. Guidelines for assessing immunocompetency in clinical trials for autoimmune diseases. Clinical Immunology (Orlando, Fla.). 123: 235-43. PMID 17329169 DOI: 10.1016/j.clim.2007.01.001  1
2007 Kulik L, Marchbank KJ, Lyubchenko T, Kuhn KA, Liubchenko GA, Haluszczak C, Gipson MG, Gibson MG, Boackle SA, Holers VM. Intrinsic B cell hypo-responsiveness in mice prematurely expressing human CR2/CD21 during B cell development. European Journal of Immunology. 37: 623-33. PMID 17301948 DOI: 10.1002/eji.200636248  1
2007 Young KA, Parrish LA, Zerbe GO, Rewers M, Deane KD, Michael Holers V, Norris JM. Perinatal and early childhood risk factors associated with rheumatoid factor positivity in a healthy paediatric population. Annals of the Rheumatic Diseases. 66: 179-83. PMID 17242018 DOI: 10.1136/ard.2006.061846  1
2007 Thurman JM, Lenderink AM, Royer PA, Coleman KE, Zhou J, Lambris JD, Nemenoff RA, Quigg RJ, Holers VM. C3a is required for the production of CXC chemokines by tubular epithelial cells after renal ishemia/reperfusion. Journal of Immunology (Baltimore, Md. : 1950). 178: 1819-28. PMID 17237432 DOI: 10.4049/jimmunol.178.3.1819  0.6
2007 Thorgersen EB, Ghebremariam YT, Thurman JM, Fung M, Nielsen EW, Holers VM, Kotwal GJ, Mollnes TE. Candidate inhibitors of porcine complement. Molecular Immunology. 44: 1827-34. PMID 17109963 DOI: 10.1016/j.molimm.2006.10.004  1
2007 Holers VM, Kulik L. Complement receptor 2, natural antibodies and innate immunity: Inter-relationships in B cell selection and activation Molecular Immunology. 44: 64-72. PMID 16876864 DOI: 10.1016/j.molimm.2006.07.003  1
2006 Schepers A, de Vries MR, van Leuven CJ, Grimbergen JM, Holers VM, Daha MR, van Bockel JH, Quax PH. Inhibition of complement component C3 reduces vein graft atherosclerosis in apolipoprotein E3-Leiden transgenic mice. Circulation. 114: 2831-8. PMID 17145993 DOI: 10.1161/CIRCULATIONAHA.106.619502  1
2006 Szakonyi G, Klein MG, Hannan JP, Young KA, Ma RZ, Asokan R, Holers VM, Chen XS. Structure of the Epstein-Barr virus major envelope glycoprotein. Nature Structural & Molecular Biology. 13: 996-1001. PMID 17072314 DOI: 10.1038/nsmb1161  1
2006 Gilbert HE, Asokan R, Holers VM, Perkins SJ. The 15 SCR Flexible Extracellular Domains of Human Complement Receptor Type 2 can Mediate Multiple Ligand and Antigen Interactions Journal of Molecular Biology. 362: 1132-1147. PMID 16950392 DOI: 10.1016/j.jmb.2006.08.012  1
2006 Mikuls TR, Holers VM, Parrish L, Kuhn KA, Conn DL, Gilkeson G, Smith EA, Kamen DL, Jonas BL, Callahan LF, Alarcón GS, Howard G, Moreland LW, Bridges SL. Anti-cyclic citrullinated peptide antibody and rheumatoid factor isotypes in African Americans with early rheumatoid arthritis. Arthritis and Rheumatism. 54: 3057-9. PMID 16948136 DOI: 10.1002/art.22200  1
2006 Holers VM. Are anti-cyclic citrullinated peptide antibodies pathogenic in rheumatoid arthritis? Nature Clinical Practice Rheumatology. 2: 400-401. PMID 16932728 DOI: 10.1038/ncprheum0247  1
2006 Girardi G, Yarilin D, Thurman JM, Holers VM, Salmon JE. Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction Journal of Experimental Medicine. 203: 2165-2175. PMID 16923853 DOI: 10.1084/jem.20061022  1
2006 Banda NK, Thurman JM, Kraus D, Wood A, Carroll MC, Arend WP, Holers VM. Alternative complement pathway activation is essential for inflammation and joint destruction in the passive transfer model of collagen-induced arthritis Journal of Immunology. 177: 1904-1912. PMID 16849503  1
2006 Asokan R, Hua J, Young KA, Gould HJ, Hannan JP, Kraus DM, Szakonyi G, Grundy GJ, Chen XS, Crow MK, Holers VM. Characterization of human complement receptor type 2 (CR2/CD21) as a receptor for IFN-alpha: a potential role in systemic lupus erythematosus. Journal of Immunology (Baltimore, Md. : 1950). 177: 383-94. PMID 16785534  1
2006 Majka DS, Holers VM. Cigarette smoking and the risk of systemic lupus erythematosus and rheumatoid arthritis Annals of the Rheumatic Diseases. 65: 561-563. PMID 16611864 DOI: 10.1136/ard.2005.046052  1
2006 Kuhn KA, Kulik L, Tomooka B, Braschler KJ, Arend WP, Robinson WH, Holers VM. Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis. The Journal of Clinical Investigation. 116: 961-73. PMID 16585962 DOI: 10.1172/JCI25422  1
2006 Kraus DM, Elliott GS, Chute H, Horan T, Pfenninger KH, Sanford SD, Foster S, Scully S, Welcher AA, Holers VM. CSMD1 is a novel multiple domain complement-regulatory protein highly expressed in the central nervous system and epithelial tissues. Journal of Immunology (Baltimore, Md. : 1950). 176: 4419-30. PMID 16547280 DOI: 10.4049/jimmunol.176.7.4419  1
2006 Thurman JM, Royer PA, Ljubanovic D, Dursun B, Lenderink AM, Edelstein CL, Holers VM. Treatment with an inhibitory monoclonal antibody to mouse factor B protects mice from induction of apoptosis and renal ischemia/reperfusion injury Journal of the American Society of Nephrology. 17: 707-715. PMID 16467447 DOI: 10.1681/ASN.2005070698  1
2006 Thurman JM, Ljubanović D, Royer PA, Kraus DM, Molina H, Barry NP, Proctor G, Levi M, Holers VM. Altered renal tubular expression of the complement inhibitor Crry permits complement activation after ischemia/reperfusion Journal of Clinical Investigation. 116: 357-368. PMID 16444293 DOI: 10.1172/JCI24521  1
2006 Thurman JM, Holers VM. The central role of the alternative complement pathway in human disease Journal of Immunology. 176: 1305-1310. PMID 16424154  1
2006 Gilbert HE, Aslam M, Guthridge JM, Holers VM, Perkins SJ. Extended flexible linker structures in the complement chimaeric conjugate CR2-Ig by scattering, analytical ultracentrifugation and constrained modelling: Implications for function and therapy Journal of Molecular Biology. 356: 397-412. PMID 16375923 DOI: 10.1016/j.jmb.2005.11.050  1
2005 Hibbert RG, Teriete P, Grundy GJ, Beavil RL, Reljic R, Holers VM, Hannan JP, Sutton BJ, Gould HJ, McDonnell JM. The structure of human CD23 and its interactions with IgE and CD21. The Journal of Experimental Medicine. 202: 751-60. PMID 16172256 DOI: 10.1084/jem.20050811  1
2005 Atkinson C, Song H, Lu B, Qiao F, Burns TA, Holers VM, Tsokos GC, Tomlinson S. Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infection. The Journal of Clinical Investigation. 115: 2444-53. PMID 16127466 DOI: 10.1172/JCI25208  1
2005 Birrell L, Kulik L, Morgan BP, Holers VM, Marchbank KJ. B cells from mice prematurely expressing human complement receptor type 2 are unresponsive to T-dependent antigens Journal of Immunology. 174: 6974-6982. PMID 15905540  1
2005 Li S, Boackle SA, Holers VM, Lambris JD, Blatteis CM. Complement component C5a is integral to the febrile response of mice to lipopolysaccharide Neuroimmunomodulation. 12: 67-80. PMID 15785108 DOI: 10.1159/000083578  1
2005 Lyubchenko T, Dal Porto J, Cambier JC, Holers VM. Coligation of the B cell receptor with complement receptor type 2 (CR2/CD21) using its natural ligand C3dg: Activation without engagement of an inhibitory signaling pathway Journal of Immunology. 174: 3264-3272. PMID 15749857  1
2005 Gilbert HE, Eaton JT, Hannan JP, Holers VM, Perkins SJ. Solution structure of the complex between CR2 SCR 1-2 and C3d of human complement: An X-ray scattering and sedimentation modelling study Journal of Molecular Biology. 346: 859-873. PMID 15713468 DOI: 10.1016/j.jmb.2004.12.006  1
2005 Hannan JP, Young KA, Guthridge JM, Asokan R, Szakonyi G, Chen XS, Holers VM. Mutational analysis of the complement receptor type 2 (CR2/CD21)-C3d interaction reveals a putative charged SCR1 binding site for C3d. Journal of Molecular Biology. 346: 845-58. PMID 15713467 DOI: 10.1016/j.jmb.2004.12.007  1
2005 Carroll MC, Holers VM. Innate autoimmunity Advances in Immunology. 86: 137-157. PMID 15705421 DOI: 10.1016/S0065-2776(04)86004-8  1
2005 Thurman JM, Lucia MS, Ljubanovic D, Holers VM. Acute tubular necrosis is characterized by activation of the alternative pathway of complement Kidney International. 67: 524-530. PMID 15673300 DOI: 10.1111/j.1523-1755.2005.67109.x  1
2005 Ferucci ED, Majka DS, Parrish LA, Moroldo MB, Ryan M, Passo M, Thompson SD, Deane KD, Rewers M, Arend WP, Glass DN, Norris JM, Holers VM. Antibodies against cyclic citrullinated peptide are associated with HLA-DR4 in simplex and multiplex polyarticular-onset juvenile rheumatoid arthritis. Arthritis and Rheumatism. 52: 239-46. PMID 15641089 DOI: 10.1002/art.20773  1
2005 Holers VM. Complement receptors and the shaping of the natural antibody repertoire Springer Seminars in Immunopathology. 26: 405-423. PMID 15614507 DOI: 10.1007/s00281-004-0186-y  1
2005 Thurman JM, Kraus DM, Girardi G, Hourcade D, Kang HJ, Royer PA, Mitchell LM, Giclas PC, Salmon J, Gilkeson G, Holers VM. A novel inhibitor of the alternative complement pathway prevents antiphospholipid antibody-induced pregnancy loss in mice Molecular Immunology. 42: 87-97. PMID 15488947 DOI: 10.1016/j.molimm.2004.07.043  1
2004 Mikuls TR, O'Dell JR, Stoner JA, Parrish LA, Arend WP, Norris JM, Holers VM. Association of rheumatoid arthritis treatment response and disease duration with declines in serum levels of IgM rheumatoid factor and anti-cyclic citrullinated peptide antibody Arthritis and Rheumatism. 50: 3776-3782. PMID 15593224 DOI: 10.1002/art.20659  1
2004 Fleming SD, Egan RP, Chai C, Girardi G, Holers VM, Salmon J, Monestier M, Tsokos GC. Anti-phospholipid antibodies restore mesenteric ischemia/reperfusion-induced injury in complement receptor 2/complement receptor 1-deficient mice. Journal of Immunology (Baltimore, Md. : 1950). 173: 7055-61. PMID 15557203  1
2004 Holers VM. Anti-C1q autoantibodies amplify pathogenic complement activation in systemic lupus erythematosus Journal of Clinical Investigation. 114: 616-619. PMID 15343378 DOI: 10.1172/JCI200422820  1
2004 Boackle SA, Culhane KK, Brown JM, Haas M, Bao L, Quigg RJ, Holers VM. CR1/CR2 deficiency alters IgG3 autoantibody production and IgA glomerular deposition in the MRL/lpr model of SLE. Autoimmunity. 37: 111-23. PMID 15293881 DOI: 10.1080/08916930410001685063  1
2004 Ohta R, Kondor N, Dohi N, Tomlinson S, Imai M, Holers VM, Okada H, Okada N. Mouse complement receptor-related gene y/p65-neutralized tumor vaccine induces antitumor activity in vivo. Journal of Immunology (Baltimore, Md. : 1950). 173: 205-13. PMID 15210776  1
2004 Holers VM, Thurman JM. The alternative pathway of complement in disease: Opportunities for therapeutic targeting Molecular Immunology. 41: 147-152. PMID 15159060 DOI: 10.1016/j.molimm.2004.03.012  1
2004 Kang HJ, Bao L, Xu Y, Quigg RJ, Giclas PC, Holers VM. Increased serum C3 levels in Crry transgenic mice partially abrogates its complement inhibitory effects Clinical and Experimental Immunology. 136: 194-199. PMID 15086380 DOI: 10.1111/j.1365-2249.2004.02450.x  1
2004 Holers VM, Boackle SA. Complement receptor 2 and autoimmunity Current Directions in Autoimmunity. 7: 33-48. PMID 14719374  1
2004 Park JW, Taube C, Joetham A, Takeda K, Kodama T, Dakhama A, McConville G, Allen CB, Sfyroera G, Shultz LD, Lambris JD, Giclas PC, Holers VM, Gelfand EW. Complement activation is critical to airway hyperresponsiveness after acute ozone exposure. American Journal of Respiratory and Critical Care Medicine. 169: 726-32. PMID 14701711 DOI: 10.1164/rccm.200307-1042OC  1
2004 Elliott MK, Jarmi T, Ruiz P, Xu Y, Holers VM, Gilkeson GS. Effects of complement factor D deficiency on the renal disease of MRL/lpr mice Kidney International. 65: 129-138. PMID 14675043 DOI: 10.1111/j.1523-1755.2004.00371.x  1
2003 Girardi G, Berman J, Redecha P, Spruce L, Thurman JM, Kraus D, Hollmann TJ, Casali P, Caroll MC, Wetsel RA, Lambris JD, Holers VM, Salmon JE. Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. The Journal of Clinical Investigation. 112: 1644-54. PMID 14660741 DOI: 10.1172/JCI200418817C1  0.6
2003 Alexander JJ, Bao L, Jacob A, Kraus DM, Holers VM, Quigg RJ. Administration of the soluble complement inhibitor, Crry-Ig, reduces inflammation and aquaporin 4 expression in lupus cerebritis. Biochimica Et Biophysica Acta. 1639: 169-76. PMID 14636948 DOI: 10.1016/j.bbadis.2003.09.005  1
2003 Majka DS, Holers VM. Can We Accurately Predict the Development of Rheumatoid Arthritis in the Preclinical Phase? Arthritis and Rheumatism. 48: 2701-2705. PMID 14558071 DOI: 10.1002/art.11224  1
2003 Bao L, Zhou J, Holers VM, Quigg RJ. Excessive matrix accumulation in the kidneys of MRL/lpr lupus mice is dependent on complement activation. Journal of the American Society of Nephrology : Jasn. 14: 2516-25. PMID 14514729 DOI: 10.1097/01.ASN.0000089831.96794.0B  1
2003 Banda NK, Kraus DM, Muggli M, Bendele A, Holers VM, Arend WP. Prevention of collagen-induced arthritis in mice transgenic for the complement inhibitor complement receptor 1-related gene/protein y Journal of Immunology. 171: 2109-2115. PMID 12902517  1
2003 Salmon JE, Girardi G, Holers VM. Activation of complement mediates antiphospholipid antibody-induced pregnancy loss Lupus. 12: 535-538. PMID 12892394 DOI: 10.1191/0961203303lu397oa  1
2003 Song H, He C, Knaak C, Guthridge JM, Holers VM, Tomlinson S. Complement receptor 2-mediated targeting of complement inhibitors to sites of complement activation. The Journal of Clinical Investigation. 111: 1875-85. PMID 12813023 DOI: 10.1172/JCI17348  1
2003 Holers VM. The complement system as a therapeutic target in autoimmunity Clinical Immunology. 107: 140-151. PMID 12804527 DOI: 10.1016/S1521-6616(03)00034-2  1
2003 Aslam M, Guthridge JM, Hack BK, Quigg RJ, Holers VM, Perkins SJ. The extended multidomain solution structures of the complement protein Crry and its chimeric conjugate Crry-Ig by scattering, analytical ultracentrifugation and constrained modelling: Implications for function and therapy Journal of Molecular Biology. 329: 525-550. PMID 12767833 DOI: 10.1016/S0022-2836(03)00492-3  1
2003 Bao L, Haas M, Kraus DM, Hack BK, Rakstang JK, Holers VM, Quigg RJ. Administration of a soluble recombinant complement C3 inhibitor protects against renal disease in MRL/lpr mice. Journal of the American Society of Nephrology : Jasn. 14: 670-9. PMID 12595503 DOI: 10.1097/01.ASN.0000051597.27127.A1  1
2003 Thurman JM, Ljubanovic D, Edelstein CL, Gilkeson GS, Holers VM. Lack of a functional alternative complement pathway ameliorates ischemic acute renal failure in mice Journal of Immunology. 170: 1517-1523. PMID 12538716  1
2003 Boackle SA, Holers VM. Role of complement in the development of autoimmunity Current Directions in Autoimmunity. 6: 154-168. PMID 12408051  1
2002 Perkins SJ, Gilbert HE, Aslam M, Hannan J, Holers VM, Goodship THJ. Solution structures of complement components by X-ray and neutron scattering and analytical ultracentrifugation Biochemical Society Transactions. 30: 996-1001. PMID 12440960 DOI: 10.1042/BST0300996  1
2002 Hannan J, Young K, Szakonyi G, Overduin MJ, Perkins SJ, Chen X, Holers VM. Structure of complement receptor (CR) 2 and CR2-C3d complexes Biochemical Society Transactions. 30: 983-989. PMID 12440958 DOI: 10.1042/BST0300983  1
2002 Banda NK, Kraus D, Vondracek A, Huynh LH, Bendele A, Holers VM, Arend WP. Mechanisms of effects of complement inhibition in murine collagen-induced arthritis. Arthritis and Rheumatism. 46: 3065-75. PMID 12428251 DOI: 10.1002/art.10591  1
2002 Salmon JE, Girardi G, Holers VM. Complement activation as a mediator of antiphospholipid antibody induced pregnancy loss and thrombosis Annals of the Rheumatic Diseases. 61. PMID 12379621  1
2002 Marchbank KJ, Kulik L, Gipson MG, Morgan BP, Holers VM. Expression of human complement receptor type 2 (CD21) in mice during early B cell development results in a reduction in mature B cells and hypogammaglobulinemia Journal of Immunology. 169: 3526-3535. PMID 12244142  1
2002 Fleming SD, Shea-Donohue T, Guthridge JM, Kulik L, Waldschmidt TJ, Gipson MG, Tsokos GC, Holers VM. Mice deficient in complement receptors 1 and 2 lack a tissue injury-inducing subset of the natural antibody repertoire. Journal of Immunology (Baltimore, Md. : 1950). 169: 2126-33. PMID 12165541  1
2002 Ulgiati D, Pham C, Holers VM. Functional analysis of the human complement receptor 2 (CR2/CD21) promoter: Characterization of Basal transcriptional mechanisms Journal of Immunology. 168: 6279-6285. PMID 12055242  1
2002 Li S, Holers VM, Boackle SA, Blatteis CM. Modulation of mouse endotoxic fever by complement Infection and Immunity. 70: 2519-2525. PMID 11953391 DOI: 10.1128/IAI.70.5.2519-2525.2002  1
2002 Bao L, Haas M, Boackle SA, Kraus DM, Cunningham PN, Park P, Alexander JJ, Anderson RK, Culhane K, Holers VM, Quigg RJ. Transgenic expression of a soluble complement inhibitor protects against renal disease and promotes survival in MRL/lpr mice. Journal of Immunology (Baltimore, Md. : 1950). 168: 3601-7. PMID 11907125 DOI: 10.4049/jimmunol.168.7.3601  1
2002 Ji H, Ohmura K, Mahmood U, Lee DM, Hofhuis FM, Boackle SA, Takahashi K, Holers VM, Walport M, Gerard C, Ezekowitz A, Carroll MC, Brenner M, Weissleder R, Verbeek JS, et al. Arthritis critically dependent on innate immune system players. Immunity. 16: 157-68. PMID 11869678 DOI: 10.1016/S1074-7613(02)00275-3  1
2001 Ulgiati D, Holers VM. CR2/CD21 proximal promoter activity is critically dependent on a cell type-specific repressor Journal of Immunology. 167: 6912-6919. PMID 11739509  1
2001 Boackle SA, Holers VM, Chen X, Szakonyi G, Karp DR, Wakeland EK, Morel L. Cr2, a candidate gene in the murine Sle1c lupus susceptibility locus, encodes a dysfunctional protein Immunity. 15: 775-785. PMID 11728339 DOI: 10.1016/S1074-7613(01)00228-X  1
2001 Rehrig S, Fleming SD, Anderson J, Guthridge JM, Rakstang J, McQueen CE, Holers VM, Tsokos GC, Shea-Donohue T. Complement inhibitor, complement receptor 1-related gene/protein y-Ig attenuates intestinal damage after the onset of mesenteric ischemia/reperfusion injury in mice Journal of Immunology. 167: 5921-5927. PMID 11698469  1
2001 Guthridge JM, Young K, Gipson MG, Sarrias MR, Szakonyi G, Chen XS, Malaspina A, Donoghue E, James JA, Lambris JD, Moir SA, Perkins SJ, Holers VM. Epitope mapping using the X-ray crystallographic structure of complement receptor type 2 (CR2)/CD21: Identification of a highly inhibitory monoclonal antibody that directly recognizes the CR2-C3d interface Journal of Immunology. 167: 5758-5766. PMID 11698449 DOI: 10.4049/jimmunol.167.10.5758  1
2001 Henson SE, Smith D, Boackle SA, Holers VM, Karp DR. Generation of recombinant human C3dg tetramers for the analysis of CD21 binding and function Journal of Immunological Methods. 258: 97-109. PMID 11684127 DOI: 10.1016/S0022-1759(01)00471-9  1
2001 Kaya Z, Afanasyeva M, Wang Y, Dohmen KM, Schlichting J, Tretter T, Fairweather D, Holers VM, Rose NR. Contribution of the innate immune system to autoimmune myocarditis: a role for complement. Nature Immunology. 2: 739-45. PMID 11477411 DOI: 10.1038/90686  1
2001 Springall T, Sheerin NS, Abe K, Holers VM, Wan H, Sacks SH. Epithelial secretion of C3 promotes colonization of the upper urinary tract by escherichia coli Nature Medicine. 7: 801-806. PMID 11433344 DOI: 10.1038/89923  1
2001 Park P, Haas M, Cunningham PN, Alexander JJ, Bao L, Guthridge JM, Kraus DM, Holers VM, Quigg RJ. Inhibiting the complement system does not reduce injury in renal ischemia reperfusion Journal of the American Society of Nephrology. 12: 1383-1390. PMID 11423567  1
2001 Szakonyi G, Guthridge JM, Li D, Young K, Holers VM, Chen XS. Structure of complement receptor 2 in complex with its C3d ligand Science. 292: 1725-1728. PMID 11387479 DOI: 10.1126/science.1059118  1
2001 Sekine H, Reilly CM, Molano ID, Garnier G, Circolo A, Ruiz P, Holers VM, Boackle SA, Gilkeson GS. Complement component C3 is not required for full expression of immune complex glomerulonephritis in MRL/lpr mice Journal of Immunology. 166: 6444-6451. PMID 11342671  1
2001 Makar KW, Ulgiati D, Hagman J, Holers VM. A site in the complement receptor 2 (CR2/CD21) silencer is necessary for lineage specific transcriptional regulation International Immunology. 13: 657-664. PMID 11312253  1
2001 Schiller B, Cunningham PN, Alexander JJ, Bao L, Holers VM, Quigg RJ. Expression of a soluble complement inhibitor protects transgenic mice from antibody-induced acute renal failure Journal of the American Society of Nephrology. 12: 71-79. PMID 11134252  1
2000 Cunningham PN, Holers VM, Alexander JJ, Guthridge JM, Carroll MC, Quigg RJ. Complement is activated in kidney by endotoxin but does not cause the ensuing acute renal failure Kidney International. 58: 1580-1587. PMID 11012892 DOI: 10.1046/j.1523-1755.2000.00319.x  1
2000 Marchbank KJ, Watson CC, Ritsema DF, Holers VM. Expression of human complement receptor 2 (CR2, CD21) in Cr2(-/-) mice restores humoral immune function Journal of Immunology. 165: 2354-2361. PMID 10946257  1
2000 Holers VM. Phenotypes of complement knockouts Immunopharmacology. 49: 125-131. PMID 10904112  1
2000 Xu C, Mao D, Holers VM, Palanca B, Cheng AM, Molina H. A critical role for murine complement regulator Crry in fetomaternal tolerance Science. 287: 498-501. PMID 10642554 DOI: 10.1126/science.287.5452.498  1
1999 Karp DR, Carlisle ML, Mobley AB, Nichols TC, Oppenheimer-Marks N, Brezinschek RI, Holers VM. Gamma-glutamyl transpeptidase is up-regulated on memory T lymphocytes. International Immunology. 11: 1791-800. PMID 10545483 DOI: 10.1093/intimm/11.11.1791  1
1999 Henson SE, Nichols TC, Holers VM, Karp DR. The ectoenzyme γ-glutamyl transpeptidase regulates antiproliferative effects of S-nitrosoglutathione on human T and B lymphocytes Journal of Immunology. 163: 1845-1852. PMID 10438918  1
1999 Davoust N, Nataf S, Holers VM, Barnum SR. Expression of the murine complement regulatory protein Crry by glial cells and neurons Glia. 27: 162-170. PMID 10417815 DOI: 10.1002/(SICI)1098-1136(199908)27:2<162::AID-GLIA6>3.0.CO;2-K  1
1999 Alexander JJ, Lim A, He C, MacDonald RL, Holers VM, Quigg RJ. Renal, central nervous system and pancreatic overexpression of recombinant soluble Crry in transgenic mice. A novel means of protection from complement-mediated injury Immunopharmacology. 42: 245-254. PMID 10408385 DOI: 10.1016/S0162-3109(99)00010-7  1
1999 Nardin A, Schlimgen R, Holers VM, Taylor RP. A prototype pathogen bound ex vivo to human erythrocyte complement receptor 1 via bispecific monoclonal antibody complexes is cleared to the liver in a mouse model European Journal of Immunology. 29: 1581-1586. PMID 10359112 DOI: 10.1002/(SICI)1521-4141(199905)29:05<1581::AID-IMMU1581>3.0.CO;2-V  1
1998 Boackle SA, Morris MA, Holers VM, Karp DR. Complement opsonization is required for presentation of immune complexes by resting peripheral blood B cells Journal of Immunology. 161: 6537-6543. PMID 9862679  1
1998 Nichols TC, Guthridge JM, Karp DR, Molina H, Fletcher DR, Holers VM. γ-glutamyl transpeptidase, an ecto-enzyme regulator of intracellular redox potential, is a component of TM4 signal transduction complexes European Journal of Immunology. 28: 4123-4129. PMID 9862348  1
1998 Quigg RJ, He C, Lim A, Berthiaume D, Alexander JJ, Kraus D, Holers VM. Transgenic mice overexpressing the complement inhibitor Crry as a soluble protein are protected from antibody-induced glomerular injury Journal of Experimental Medicine. 188: 1321-1331. PMID 9763611 DOI: 10.1084/jem.188.7.1321  1
1998 Fang Y, Xu C, Fu YX, Holers VM, Molina H. Expression of complement receptors 1 and 2 on follicular dendritic cells is necessary for the generation of a strong antigen-specific IgG response Journal of Immunology. 160: 5273-5279. PMID 9605124  1
1998 Makar KW, Pham CTN, Dehoff MH, O'Connor SM, Jacobi SM, Holers VM. An intronic silencer regulates B lymphocyte cell- and stage-specific expression of the human complement receptor type 2 (CR2, CD21) gene Journal of Immunology. 160: 1268-1278. PMID 9570543  1
1998 Kozono Y, Abe R, Kozono H, Kelly RG, Azuma T, Holers VM. Cross-linking CD21/CD35 or CD19 increases both B7-1 and B7-2 expression on murine splenic B cells Journal of Immunology. 160: 1565-1572. PMID 9469411  1
1997 Quigg RJ, Alexander JJ, Frederick Lo C, Lim A, He C, Holers VM. Characterization of C3-binding proteins on mouse neutrophils and platelets Journal of Immunology. 159: 2438-2444. PMID 9278336  1
1997 Takahashi K, Kozono Y, Waldschmidt TJ, Berthiaume D, Quigg RJ, Baron A, Holers VM. Mouse complement receptors type 1 (CR1;CD35) and type 2 (CR2;CD21): expression on normal B cell subpopulations and decreased levels during the development of autoimmunity in MRL/lpr mice. Journal of Immunology (Baltimore, Md. : 1950). 159: 1557-69. PMID 9233655  1
1997 Kawamoto Y, Kojima K, Hitsumoto Y, Okada H, Holers VM, Miyama A. The serum resistance of malaria-infected erythrocytes Immunology. 91: 7-12. PMID 9203959  1
1997 Alexander JJ, He C, Adler S, Holers VM, Quigg RJ. Characterization of C3 receptors on cultured rat glomerular endothelial cells Kidney International. 51: 1124-1132. PMID 9083278  1
1997 Boackle SA, Holers VM, Karp DR. CD21 augments antigen presentation in immune individuals European Journal of Immunology. 27: 122-129. PMID 9022008 DOI: 10.1002/eji.1830270119  1
1996 Sawant-Mane S, Piddlesden SJ, Morgan BP, Holers VM, Koski CL. CD59 homologue regulates complement-dependent cytolysis of rat Schwann cells Journal of Neuroimmunology. 69: 63-71. PMID 8823377 DOI: 10.1016/S0165-5728(96)00048-3  1
1996 Rogers CA, Gasque P, Piddlesden SJ, Okada N, Holers VM, Morgan BP. Expression and function of membrane regulators of complement on rat astrocytes in culture Immunology. 88: 153-161. PMID 8707343  1
1996 Kozono Y, Kotzin BL, Holers VM. Resting B cells from New Zealand Black mice demonstrate a defect in apoptosis induction following surface IgM ligation Journal of Immunology. 156: 4498-4503. PMID 8666826  1
1995 Kozono Y, Duke RC, Schleicher MS, Holers VM. Co-ligation of mouse complement receptors 1 and 2 with surface IgM rescues splenic B cells and WEHI-231 cells from anti-surface IgM-induced apoptosis European Journal of Immunology. 25: 1013-1017. PMID 7737272  1
1995 Molina H, Perkins SJ, Guthridge J, Gorka J, Kinoshita T, Holers VM. Characterization of a complement receptor 2 (CR2, CD21) ligand binding site for C3: An initial model of ligand interaction with two linked short consensus repeat modules Journal of Immunology. 154: 5426-5435. PMID 7730644  1
1995 Dunster LM, Schneider-Schaulies J, Dehoff MH, Holers VM, Schwartz-Albiez R, Ter Neulen V. Moesin, and not the murine functional homologue (Crry/p65) of human membrane cofactor protein (CD46), is involved in the entry of measles virus (strain Edmonston) into susceptible murine cell lines Journal of General Virology. 76: 2085-2089. PMID 7636492  1
1995 Quigg RJ, Holers VM. Characterization of rat complement receptors and regulatory proteins: CR2 and Crry are conserved, and the C3b receptor of neutrophils and platelets is distinct from CR1 Journal of Immunology. 155: 1481-1488. PMID 7636211  1
1995 Bouillie S, Barel M, Drane P, Cassinat B, Balbo M, Holers VM, Frade R. Epstein-Barr virus/C3d receptor (CR2, CD21) activated by its extracellular ligands regulates pp105 phosphorylation through two distinct pathways European Journal of Immunology. 25: 2661-2667. PMID 7589142 DOI: 10.1002/eji.1830250939  1
1995 Quigg RJ, Morgan BP, Holers VM, Adler S, Sneed AE, Lo CF. Complement regulation in the rat glomerulus: Crry and CD59 regulate complement in glomerular mesangial and endothelial cells Kidney International. 48: 412-421. PMID 7564108  1
1995 Shima M, Teitelbaum SL, Holers VM, Ruzicka C, Osmack P, Ross FP. Macrophage-colony-stimulating factor regulates expression of the integrins α4β1 and α5β1 by marine bone marrow macrophages Proceedings of the National Academy of Sciences of the United States of America. 92: 5179-5183. PMID 7539144 DOI: 10.1073/pnas.92.11.5179  1
1995 Quigg RJ, Holers VM, Morgan BP, Sneed AE. Crry and CD59 regulate complement in rat glomerular epithelial cells and are inhibited by the nephritogenic antibody of passive Heymann nephritis Journal of Immunology. 154: 3437-3443. PMID 7534798  1
1995 Kim YU, Kinoshita T, Molina H, Hourcade D, Seya T, Wagner LM, Holers VM. Mouse complement regulatory protein Crry/p65 uses the specific mechanisms of both human decay-accelerating factor and membrane cofactor protein. The Journal of Experimental Medicine. 181: 151-9. PMID 7528766 DOI: 10.1084/jem.181.1.151  1
1994 Molina H, Kinoshita T, Webster CB, Holers VM. Analysis of C3b/C3d binding sites and factor I cofactor regions within mouse complement receptors 1 and 2 Journal of Immunology. 153: 789-795. PMID 8021513  1
1994 Graham IL, Anderson DC, Holers VM, Brown EJ. Complement receptor 3 (CR3, Mac-1, integrin αMβ2, CD11b/CD18) is required for tyrosine phosphorylation of paxillin in adherent and nonadherent neutrophils Journal of Cell Biology. 127: 1139-1147. PMID 7525604  1
1993 Foley S, Li B, Dehoff M, Molina H, Holers VM. Mouse Crry/p65 is a regulator of the alternative pathway of complement activation European Journal of Immunology. 23: 1381-1384. PMID 8500531 DOI: 10.1002/eji.1830230630  1
1993 Li B, Sallee C, Dehoff M, Foley S, Molina H, Holers VM. Mouse Crry/p65: Characterization of monoclonal antibodies and the tissue distribution of a functional homologue of human MCP and DAF Journal of Immunology. 151: 4295-4305. PMID 7691944  1
1992 Hourcade D, Garcia AD, Post TW, Taillon-Miller P, Holers VM, Wagner LM, Bora NS, Atkinson JP. Analysis of the human regulators of complement activation (RCA) gene cluster with yeast artificial chromosomes (YACs). Genomics. 12: 289-300. PMID 1740338 DOI: 10.1016/0888-7543(92)90376-4  1
1992 Molina H, Wong W, Kinoshita T, Brenner C, Foley S, Holers VM. Distinct receptor and regulatory properties of recombinant mouse complement receptor 1 (CR1) and crry, the two genetic homologues of human CR1 Journal of Experimental Medicine. 175: 121-129. PMID 1730912  1
1992 Emlen W, Holers VM, Arend WP, Kotzin B. Regulation of nuclear antigen expression on the cell surface of human monocytes Journal of Immunology. 148: 3042-3048. PMID 1578130  1
1992 Moulds JM, Krych M, Holers VM, Liszewski MK, Atkinson JP. Genetics of the complement system and rheumatic diseases Rheumatic Disease Clinics of North America. 18: 893-914. PMID 1455049  1
1992 Levy E, Ambrus J, Kahl L, Molina H, Tung K, Holers VM. T lymphocyte expression of complement receptor 2 (CR2/CD21): A role in adhesive cell-cell interactions and dysregulation in a patient with systemic lupus erythematosus (SLE) Clinical and Experimental Immunology. 90: 235-244. PMID 1424280  1
1991 Ballard LL, Brown EJ, Holers VM. Expression of the fibronectin receptor VLA-5 is regulated during human B cell differentiation and activation Clinical and Experimental Immunology. 84: 336-346. PMID 1709071  1
1991 Rayhel EJ, Dehoff MH, Holers VM. Characterization of the human complement receptor 2 (CR2, CD21) promoter reveals sequences shared with regulatory regions of other developmentally restricted B cell proteins Journal of Immunology. 146: 2021-2026. PMID 1706386  1
1991 Carel JC, Holers VM, Chick WL, Littman D, Lacy PE. Expression of functional human Epstein-Barr virus/C3d receptor ([CR2] CD21) on insulinoma cell line: Induction of tumor rejection but not diabetes in syngeneic rats Diabetes. 40: 809-814. PMID 1647992  1
1990 Molina H, Kinoshita T, Inoue K, Carel JC, Holers VM. A molecular and immunochemical characterization of mouse CR2: Evidence for a single gene model of mouse complement receptors 1 and 2 Journal of Immunology. 145: 2974-2983. PMID 2145366  1
1990 Secrist H, Holers VM, Levine A, Egan M, Nahm MH, Butch AW, Peters M. Induction of IL-4 and IL-6 synthesis in vitro: Variation in signaling requirements and kinetics are dependent on the anatomic source of the responding mononuclear cells Regional Immunology. 3: 341-348. PMID 2132759  1
1990 Hourcade D, Post TW, Holers VM, Lublin DM, Atkinson JP. Polymorphisms of the regulators of complement activation gene cluster Complement and Inflammation. 7: 302-314. PMID 2088670  1
1990 Carel JC, Myones BL, Frazier B, Holers VM. Structural requirements for C3d,g/Epstein-Barr virus receptor (CR2/CD21) ligand binding, internalization, and viral infection Journal of Biological Chemistry. 265: 12293-12299. PMID 1695627  1
1989 Hourcade D, Holers VM, Atkinson JP. The regulators of complement activation (RCA) gene cluster Advances in Immunology. 45: 381-416. PMID 2665442  1
1989 O'Dell JR, Steigerwald JC, Kennaugh RC, Hawkins R, Holers VM, Kotzin BL. Lack of clinical benefit after treatment of systemic sclerosis with total lymphoid irradiation Journal of Rheumatology. 16: 1050-1054. PMID 2573727  1
1989 Fujisaku A, Harley JB, Frank MB, Gruner BA, Frazier B, Holers VM. Genomic organization and polymorphisms of the human C3d/Epstein-Barr virus receptor Journal of Biological Chemistry. 264: 2118-2125. PMID 2563370  1
1989 Holers VM. Complement receptors The Year in Immunology. 4: 231-240. PMID 2538973  1
1989 Holers VM, Ruff TG, Parks DL, McDonald JA, Ballard LL, Brown EJ. Molecular cloning of a murine fibronectin receptor and its expression during inflammation. Expression of VLA-5 is increased in activated peritoneal macrophages in a manner discordant from major histocompatibility complex class II Journal of Experimental Medicine. 169: 1589-1605. PMID 2523953  1
1989 Bora NS, Lublin DM, Kumar BV, Hockett RD, Holers VM, Atkinson JP. Structural gene for human membrane cofactor protein (MCP) of complement maps to within 100 kb for the 3' end of the C3b/C4b receptor gene Journal of Experimental Medicine. 169: 597-602. PMID 2521358  1
1989 Carel JC, Frazier B, Ley TJ, Holers VM. Analysis of epitope expression and the functional repertoire of recombinant complement receptor 2 (CR2/CD21) in mouse and human cells Journal of Immunology. 143: 923-930. PMID 2473114  1
1988 Hourcade D, Miesner DR, Atkinson JP, Holers VM. Identification of an alternative polyadenylation site in the human C3b/C4b receptor (complement receptor type 1) transcriptional unit and prediction of a secreted form of complement receptor type 1 Journal of Experimental Medicine. 168: 1255-1270. PMID 2971757  1
1987 Holers VM, Chaplin DD, Leykam JF, Gruner BA, Kumar V, Atkinson JP. Human complement C3b/C4b receptor (CRI) mRNA polymorphism that correlates with the CRI allelic molecular weight polymorphism Proceedings of the National Academy of Sciences of the United States of America. 84: 2459-2463. PMID 3031685 DOI: 10.1073/pnas.84.8.2459  1
1987 Van Dyne S, Holers VM, Lublin DM, Atkinson JP. The polymorphism of the C3b/C4b receptor in the normal population and in patients with systemic lupus erythematosus Clinical and Experimental Immunology. 68: 570-579. PMID 2958190  1
1987 McNearney TA, Odell C, Holers VM, Spear PG, Atkinson JP. Herpes simplex virus glycoproteins gC-1 and gC-2 bind to the third component of complement and provide protection against complement-mediated neutralization of viral infectivity Journal of Experimental Medicine. 166: 1525-1535. PMID 2824652  1
1987 Medof ME, Lublin DM, Holers VM, Ayers DJ, Getty RR, Leykam JF, Atkinson JP, Tykocinski ML. Cloning and characterization of cDNAs encoding the complete sequence of decay-accelerating factor of human complement Proceedings of the National Academy of Sciences of the United States of America. 84: 2007-2011. PMID 2436222 DOI: 10.1073/pnas.84.7.2007  1
1986 Holers VM, Seya T, Brown E, O'Shea JJ, Atkinson JP. Structural and functional studies on the human C3b/C4b receptor (CR1) purified by affinity chromatography using a monoclonal antibody Complement. 3: 63-78. PMID 2945695  1
1986 Nickells MW, Seya T, Holers VM, Atkinson JP. Analysis of C3b/C4b receptor (CR1) polymorphic variants by tryptic peptide mapping Molecular Immunology. 23: 661-668. PMID 2943987 DOI: 10.1016/0161-5890(86)90104-5  1
1986 Yu GH, Holers VM, Seya T, Ballard L, Atkinson JP. Identification of a third component of complement-binding glycoprotein of human platelets Journal of Clinical Investigation. 78: 494-501. PMID 2942562  1
1985 Holers VM, Cole JL, Lublin DM, Seya T, Atkinson JP. Human C3b- and C4b-regulatory proteins: a new multi-gene family. Immunology Today. 6: 188-92. PMID 25289982 DOI: 10.1016/0167-5699(85)90114-8  1
1985 Holers VM, Kotzin BL. Human peripheral blood monocytes display surface antigens recognized by monoclonal antinuclear antibodies Journal of Clinical Investigation. 76: 991-998. PMID 3876357  1
1985 Seya T, Holers VM, Atkinson JP. Purification and functional analysis of the polymorphic variants of the C3b/C4b receptor (CR1) and comparison with H, C4b-binding protein (C4bp), and decay accelerating factor (DAF) Journal of Immunology. 135: 2661-2667. PMID 3161944  1
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