Jordan S. Orange - Publications

Affiliations: 
Cell and Molecular Biology University of Pennsylvania, Philadelphia, PA, United States 
Area:
Immunology

215 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Kritikou JS, Oliveira MM, Record J, Saeed MB, Nigam SM, He M, Keszei M, Wagner AK, Brauner H, Sendel A, Sedimbi SK, Rentouli S, Lane DP, Snapper SB, Kärre K, ... ... Orange JS, et al. Constitutive WASp activation leads to abnormal cytotoxic cells with increased response against tumors. Jci Insight. PMID 33621210 DOI: 10.1172/jci.insight.140273  0.361
2020 Mace EM, Paust S, Conte MI, Baxley RM, Schmit MM, Patil SL, Guilz NC, Mukherjee M, Pezzi AE, Chmielowiec J, Tatineni S, Chinn IK, Akdemir ZC, Jhangiani SN, Muzny DM, ... ... Orange JS, et al. Human NK cell deficiency as a result of biallelic mutations in MCM10. The Journal of Clinical Investigation. PMID 32865517 DOI: 10.1172/Jci134966  0.371
2020 Clavijo-Salomon MA, Salcedo R, Roy S, das Neves RX, Dzutsev A, Sales-Campos H, Borbely KS, Silla L, Orange JS, Mace EM, Barbuto JAM, Trinchieri G. Human NK cells prime inflammatory DC precursors to induce Tc17 differentiation. Blood Advances. 4: 3990-4006. PMID 32841340 DOI: 10.1182/bloodadvances.2020002084  0.368
2020 Quinn J, Orange JS, Modell V, Modell F. The case for severe combined immunodeficiency (SCID) and T cell lymphopenia newborn screening: saving lives…one at a time. Immunologic Research. PMID 32128663 DOI: 10.1007/S12026-020-09117-9  0.309
2020 Lam MT, Mace EM, Orange JS. A Research-Driven Approach to the Identification of Novel Natural Killer Cell Deficiencies Affecting Cytotoxic Function. Blood. PMID 31945148 DOI: 10.1182/blood.2019000925  0.381
2019 Orange JS. How I Manage Natural Killer Cell Deficiency. Journal of Clinical Immunology. PMID 31754930 DOI: 10.1007/s10875-019-00711-7  0.321
2019 Ravell JC, Matsuda-Lennikov M, Chauvin SD, Zou J, Biancalana M, Deeb SJ, Price S, Su HC, Notarangelo G, Jiang P, Morawski A, Kanellopoulou C, Binder KW, Mukherjee R, Anibal JT, ... ... Orange JS, et al. Defective glycosylation and multisystem abnormalities characterize the primary immunodeficiency XMEN disease. The Journal of Clinical Investigation. PMID 31714901 DOI: 10.1172/Jci131116  0.32
2019 Vargas-Hernández A, Witalisz-Siepracka A, Prchal-Murphy M, Klein K, Mahapatra S, Al-Herz W, Mace EM, Carisey AF, Orange JS, Sexl V, Forbes LR. Human STAT5b mutation causes dysregulated human natural killer cell maturation and impaired lytic function. The Journal of Allergy and Clinical Immunology. PMID 31600547 DOI: 10.1016/j.jaci.2019.09.016  0.352
2019 Aird A, Lagos M, Vargas-Hernández A, Posey JE, Coban-Akdemir Z, Jhangiani S, Mace EM, Reyes A, King A, Cavagnaro F, Forbes LR, Chinn IK, Lupski JR, Orange JS, Poli MC. Novel Heterozygous Mutation in Is Associated With Early Onset CVID and a Functional Defect in NK Cells Complicated by Disseminated CMV Infection and Severe Nephrotic Syndrome. Frontiers in Pediatrics. 7: 303. PMID 31417880 DOI: 10.3389/fped.2019.00303  0.343
2019 Serwas NK, Hoeger B, Ardy RC, Stulz SV, Sui Z, Memaran N, Meeths M, Krolo A, Yüce Petronczki Ö, Pfajfer L, Hou TZ, Halliday N, Santos-Valente E, Kalinichenko A, Kennedy A, ... ... Orange JS, et al. Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis. Nature Communications. 10: 3106. PMID 31308374 DOI: 10.1038/S41467-019-10812-X  0.41
2019 Lim HK, Huang SXL, Chen J, Kerner G, Gilliaux O, Bastard P, Dobbs K, Hernandez N, Goudin N, Hasek ML, García Reino EJ, Lafaille FG, Lorenzo L, Luthra P, Kochetkov T, ... ... Orange JS, et al. Severe influenza pneumonitis in children with inherited TLR3 deficiency. The Journal of Experimental Medicine. PMID 31217193 DOI: 10.1084/Jem.20181621  0.319
2019 Chaimowitz NS, Branch J, Reyes A, Vargas-Hernández A, Orange JS, Forbes LR, Ehlayel M, Purayil SC, Al-Nesf MA, Vogel TP. A Novel Mutation in a Qatari Patient With Hyper-IgE Syndrome. Frontiers in Pediatrics. 7: 130. PMID 31069200 DOI: 10.3389/Fped.2019.00130  0.356
2019 Pandey R, Bakay M, Hain HS, Strenkowski B, Yermakova A, Kushner JA, Orange JS, Hakonarson H. The Autoimmune Disorder Susceptibility Gene Restrains NK Cell Function in YTS NK Cell Line and Knockout Mice. Frontiers in Immunology. 10: 68. PMID 30774629 DOI: 10.3389/Fimmu.2019.00068  0.46
2019 Burrage LC, Reynolds JJ, Baratang NV, Phillips JB, Wegner J, McFarquhar A, Higgs MR, Christiansen AE, Lanza DG, Seavitt JR, Jain M, Li X, Parry DA, Raman V, Chitayat D, ... ... Orange JS, et al. Bi-allelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes. American Journal of Human Genetics. PMID 30773277 DOI: 10.1016/J.Ajhg.2019.01.007  0.31
2019 Mahapatra S, Shearer WT, Minard CG, Mace E, Paul M, Orange JS. NK cells in treated HIV-infected children display altered phenotype and function. The Journal of Allergy and Clinical Immunology. PMID 30735686 DOI: 10.1016/J.Jaci.2018.11.052  0.313
2019 Mace EM, Orange JS. Emerging insights into human health and NK cell biology from the study of NK cell deficiencies. Immunological Reviews. 287: 202-225. PMID 30565241 DOI: 10.1111/imr.12725  0.384
2019 Deshpande D, Orange J. Reprogramming Human T Cell Function and Specificity With Non–Viral Genome Targeting Pediatrics. 144. DOI: 10.1542/Peds.2019-2461Qqqq  0.34
2019 Dixon A, Gunesch J, Orange J, Mace E. NCAM Expression Regulates Integrin and Actin Cytoskeletal Function in Human Natural Killer Cells Biophysical Journal. 116: 414a. DOI: 10.1016/J.Bpj.2018.11.2232  0.37
2019 Prince AL, Watkin LB, Orange JS, Aagaard KM, Mace EM. 106: Maturation of cord blood natural killer (NK) cells differs amongst neonates American Journal of Obstetrics and Gynecology. 220: S85. DOI: 10.1016/J.Ajog.2017.10.213  0.346
2018 Banerjee PP, Pang L, Soldan SS, Miah SM, Eisenberg A, Maru S, Waldman A, Smith EA, Rosenberg-Hasson Y, Hirschberg D, Smith A, Ablashi DV, Campbell KS, Orange JS. KIR2DL4-HLAG interaction at human NK cell-oligodendrocyte interfaces regulates IFN-γ-mediated effects. Molecular Immunology. PMID 30482463 DOI: 10.1016/J.Molimm.2018.09.027  0.441
2018 Hagl B, Spielberger BD, Thoene S, Bonnal S, Mertes C, Winter C, Nijman IJ, Verduin S, Eberherr AC, Puel A, Schindler D, Ruland J, Meitinger T, Gagneur J, Orange JS, et al. Somatic alterations compromised molecular diagnosis of DOCK8 hyper-IgE syndrome caused by a novel intronic splice site mutation. Scientific Reports. 8: 16719. PMID 30425284 DOI: 10.1038/S41598-018-34953-Z  0.355
2018 Pandey R, Bakay M, Hain HS, Strenkowski B, Elsaqa BZB, Roizen JD, Kushner JA, Orange JS, Hakonarson H. CLEC16A regulates splenocyte and NK cell function in part through MEK signaling. Plos One. 13: e0203952. PMID 30226884 DOI: 10.1371/Journal.Pone.0203952  0.346
2018 Samaha H, Pignata A, Fousek K, Ren J, Lam FW, Stossi F, Dubrulle J, Salsman VS, Krishnan S, Hong SH, Baker ML, Shree A, Gad AZ, Shum T, Fukumura D, ... ... Orange JS, et al. A homing system targets therapeutic T cells to brain cancer. Nature. PMID 30185905 DOI: 10.1038/S41586-018-0499-Y  0.358
2018 Gunesch JT, Angelo LS, Mahapatra S, Deering RP, Kowalko JE, Sleiman P, Tobias JW, Monaco-Shawver L, Orange JS, Mace EM. Genome-wide analyses and functional profiling of human NK cell lines. Molecular Immunology. PMID 30054012 DOI: 10.1016/j.molimm.2018.07.015  0.316
2018 Gunesch JT, Angelo LS, Mahapatra S, Deering RP, Kowalko JE, Sleiman P, Tobias JW, Monaco-Shawver L, Orange JS, Mace EM. Genome-wide analyses and functional profiling of human NK cell lines. Molecular Immunology. PMID 30054012 DOI: 10.1016/j.molimm.2018.07.015  0.316
2018 Poli MC, Ebstein F, Nicholas SK, de Guzman MM, Forbes LR, Chinn IK, Mace EM, Vogel TP, Carisey AF, Benavides F, Coban-Akdemir ZH, Gibbs RA, Jhangiani SN, Muzny DM, Carvalho CMB, ... ... Orange JS, et al. Heterozygous Truncating Variants in POMP Escape Nonsense-Mediated Decay and Cause a Unique Immune Dysregulatory Syndrome. American Journal of Human Genetics. PMID 29805043 DOI: 10.1016/J.Ajhg.2018.04.010  0.321
2018 Mace EM, Orange JS. Discovering the Cause of Wiskott-Aldrich Syndrome and Laying the Foundation for Understanding Immune Cell Structuring. Journal of Immunology (Baltimore, Md. : 1950). 200: 3667-3670. PMID 29784762 DOI: 10.4049/Jimmunol.1800518  0.337
2018 DiNardo AR, Nishiguchi T, Mace EM, Rajapakshe K, Mtetwa G, Kay A, Maphalala G, Secor WE, Mejia R, Orange JS, Coarfa C, Bhalla KN, Graviss EA, Mandalakas AM, Makedonas G. Schistosomiasis Induces Persistent DNA Methylation and Tuberculosis-Specific Immune Changes. Journal of Immunology (Baltimore, Md. : 1950). PMID 29752313 DOI: 10.4049/Jimmunol.1800101  0.328
2018 Konno H, Chinn IK, Hong D, Orange JS, Lupski JR, Mendoza A, Pedroza LA, Barber GN. Pro-inflammation Associated with a Gain-of-Function Mutation (R284S) in the Innate Immune Sensor STING. Cell Reports. 23: 1112-1123. PMID 29694889 DOI: 10.1016/J.Celrep.2018.03.115  0.323
2018 de Albuquerque JAT, Banerjee PP, Castoldi A, Ma R, Zurro NB, Ynoue LH, Arslanian C, Barbosa-Carvalho MUW, Correia-Deur JEM, Weiler FG, Dias-da-Silva MR, Lazaretti-Castro M, Pedroza LA, Câmara NOS, Mace E, ... Orange JS, et al. The Role of AIRE in the Immunity Against in a Model of Human Macrophages. Frontiers in Immunology. 9: 567. PMID 29666621 DOI: 10.3389/Fimmu.2018.00567  0.379
2018 Chinn IK, Eckstein OS, Peckham-Gregory EC, Goldberg BR, Forbes LR, Nicholas SK, Mace EM, Vogel TP, Abhyankar HA, Diaz MI, Heslop HE, Krance RA, Martinez CA, Nguyen TC, Bashir DA, ... ... Orange JS, et al. Genetic and mechanistic diversity in pediatric hemophagocytic lymphohistiocytosis. Blood. PMID 29632024 DOI: 10.1182/Blood-2017-11-814244  0.329
2018 Gwalani LA, Orange JS. Single Degranulations in NK Cells Can Mediate Target Cell Killing. Journal of Immunology (Baltimore, Md. : 1950). PMID 29592963 DOI: 10.4049/Jimmunol.1701500  0.45
2018 Carisey AF, Mace EM, Saeed MB, Davis DM, Orange JS. Nanoscale Dynamism of Actin Enables Secretory Function in Cytolytic Cells. Current Biology : Cb. PMID 29398219 DOI: 10.1016/J.Cub.2017.12.044  0.43
2018 Ruiz-García R, Vargas-Hernandez A, Chinn IK, Angelo LS, Cao TN, Coban-Akdemir Z, Jhangiani SN, Meng Q, Forbes LR, Muzny DM, Allende LM, Ehlayel MS, Gibbs RA, Lupski JR, Uzel G, ... Orange JS, et al. Mutations in PI3K110δ cause impaired NK cell function partially rescued by rapamycin treatment. The Journal of Allergy and Clinical Immunology. PMID 29330011 DOI: 10.1016/J.Jaci.2017.11.042  0.351
2018 Lesteberg K, Orange J, Makedonas G. Recycling endosomes in human cytotoxic T lymphocytes constitute an auxiliary intracellular trafficking pathway for newly synthesized perforin. Immunologic Research. 65: 1031-1045. PMID 28822075 DOI: 10.1007/S12026-017-8945-8  0.325
2017 Vargas-Hernandez A, Mace EM, Zimmerman O, Zerbe CS, Freeman AF, Rosenzweig S, Leiding JW, Torgerson T, Altman MC, Schussler E, Cunningham-Rundles C, Chinn IK, Carisey AF, Hanson IC, Rider NL, ... ... Orange JS, et al. Ruxolitinib partially reverses functional NK cell deficiency in patients with STAT1 gain-of-function mutations. The Journal of Allergy and Clinical Immunology. PMID 29111217 DOI: 10.1016/J.Jaci.2017.08.040  0.443
2017 Marcenaro E, Notarangelo LD, Orange JS, Vivier E. Editorial: NK Cell Subsets in Health and Disease: New Developments. Frontiers in Immunology. 8: 1363. PMID 29093717 DOI: 10.3389/Fimmu.2017.01363  0.354
2017 Mamonkin M, Mukherjee M, Srinivasan M, Sharma S, Gomes-Silva D, Mo F, Krenciute G, Orange JS, Brenner MK. Reversible Transgene Expression Reduces Fratricide and Permits 4-1BB Costimulation of CAR T Cells Directed to T-Cell Malignancies. Cancer Immunology Research. PMID 29079655 DOI: 10.1158/2326-6066.Cir-17-0126  0.373
2017 Nishimura CD, Brenner DA, Mukherjee M, Hirsch RA, Ott L, Wu MF, Liu H, Dakhova O, Orange JS, Brenner MK, Lin CY, Arber C. C-MPL provides tumor-targeted T cell receptor-transgenic T cells with co-stimulation and cytokine signals. Blood. PMID 29079582 DOI: 10.1182/Blood-2017-02-769463  0.36
2017 Bielamowicz K, Fousek K, Byrd TT, Samaha H, Mukherjee M, Aware N, Wu MF, Orange JS, Sumazin P, Man TK, Joseph SK, Hegde M, Ahmed N. Trivalent CAR T-cells Overcome Interpatient Antigenic Variability in Glioblastoma. Neuro-Oncology. PMID 29016929 DOI: 10.1093/Neuonc/Nox182  0.347
2017 Gomes-Silva D, Mukherjee M, Srinivasan M, Krenciute G, Dakhova O, Zheng Y, Cabral JMS, Rooney CM, Orange JS, Brenner MK, Mamonkin M. Tonic 4-1BB Costimulation in Chimeric Antigen Receptors Impedes T Cell Survival and Is Vector-Dependent. Cell Reports. 21: 17-26. PMID 28978471 DOI: 10.1016/J.Celrep.2017.09.015  0.358
2017 Tzannou I, Nicholas SK, Lulla P, Aguayo-Hiraldo PI, Misra A, Martinez CA, Machado AA, Orange JS, Piedra PA, Vera JF, Leen AM. Immunologic Profiling of Human Metapneumovirus for the Development of Targeted Immunotherapy. The Journal of Infectious Diseases. 216: 678-687. PMID 28934427 DOI: 10.1093/Infdis/Jix358  0.387
2017 Rios X, Chinn IK, Orange JS, Hanson CI, Rider NL. T-Cell Lymphopenia Detected by Newborn Screening in Two Siblings with an Xq13.1 Duplication. Frontiers in Pediatrics. 5: 156. PMID 28770187 DOI: 10.3389/Fped.2017.00156  0.354
2017 Mahapatra S, Mace EM, Minard CG, Forbes LR, Vargas-Hernandez A, Duryea TK, Makedonas G, Banerjee PP, Shearer WT, Orange JS. High-resolution phenotyping identifies NK cell subsets that distinguish healthy children from adults. Plos One. 12: e0181134. PMID 28767726 DOI: 10.1371/Journal.Pone.0181134  0.396
2017 Jacquemet G, Paatero I, Carisey AF, Padzik A, Orange JS, Hamidi H, Ivaska J. FiloQuant reveals increased filopodia density during breast cancer progression. The Journal of Cell Biology. PMID 28765364 DOI: 10.1083/Jcb.201704045  0.325
2017 Liu E, Tong Y, Dotti G, Shaim H, Savoldo B, Mukherjee M, Orange J, Wan X, Lu X, Reynolds A, Gagea M, Banerjee P, Cai R, Bdaiwi MH, Basar R, et al. Cord blood NK cells engineered to express IL-15 and a CD19-targeted CAR show long-term persistence and potent anti-tumor activity. Leukemia. PMID 28725044 DOI: 10.1038/Leu.2017.226  0.438
2017 Pal M, Schwab L, Yermakova A, Mace EM, Claus R, Krahl AC, Woiterski J, Hartwig UF, Orange JS, Handgretinger R, André MC. Tumor-priming converts NK cells to memory-like NK cells. Oncoimmunology. 6: e1317411. PMID 28680749 DOI: 10.1080/2162402X.2017.1317411  0.436
2017 Miot C, Imai K, Imai C, Mancini AJ, Kucuk ZY, Kawai T, Nishikomori R, Ito E, Pellier I, Dupuis Girod S, Rosain J, Sasaki S, Chandrakasan S, Pachlopnik Schmid J, Okano T, ... ... Orange JS, et al. Hematopoietic stem cell transplantation in 29 patients hemizygous for hypomorphic IKBKG / NEMO mutations. Blood. PMID 28679735 DOI: 10.1182/Blood-2017-03-771600  0.312
2017 Mukherjee M, Mace EM, Carisey AF, Ahmed N, Orange JS. Quantitative Imaging Approaches to Study the CAR Immunological Synapse. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 28663103 DOI: 10.1016/J.Ymthe.2017.06.003  0.39
2017 Chinn IK, Sanders RP, Stray-Pedersen A, Coban-Akdemir ZH, Kim VH, Dadi H, Roifman CM, Quigg T, Lupski JR, Orange JS, Hanson IC. Novel Combined Immune Deficiency and Radiation Sensitivity Blended Phenotype in an Adult with Biallelic Variations in ZAP70 and RNF168. Frontiers in Immunology. 8: 576. PMID 28603521 DOI: 10.3389/Fimmu.2017.00576  0.347
2017 Exley MA, Orange JS. Overview: NK-cell-based Immunotherapies: Toward & Into Clinical Trials. Clinical Immunology (Orlando, Fla.). 177: 1-2. PMID 28583665 DOI: 10.1016/J.Clim.2017.05.004  0.343
2017 Singla S, Wenderfer SE, Muscal E, Sagcal-Gironella ACP, Orange JS, Makedonas G. Changes in Frequency and Activation Status of Major CD4(+) T-Cell Subsets after Initiation of Immunosuppressive Therapy in a Patient with New Diagnosis Childhood-Onset Systemic Lupus Erythematosus. Frontiers in Pediatrics. 5: 104. PMID 28555177 DOI: 10.3389/Fped.2017.00104  0.373
2017 Samson EB, Tsao DS, Zimak J, McLaughlin RT, Trenton NJ, Mace EM, Orange JS, Schweikhard V, Diehl MR. The coordinating role of IQGAP1 in the regulation of local, endosome-specific actin networks. Biology Open. PMID 28455356 DOI: 10.1242/Bio.022624  0.366
2017 Hsu HT, Carisey AF, Orange JS. Measurement of Lytic Granule Convergence After Formation of an NK Cell Immunological Synapse. Methods in Molecular Biology (Clifton, N.J.). 1584: 497-515. PMID 28255722 DOI: 10.1007/978-1-4939-6881-7_31  0.453
2017 Montecalvo A, Watkins SC, Orange J, Kane LP. Inducible turnover of optineurin regulates T cell activation. Molecular Immunology. 85: 9-17. PMID 28192730 DOI: 10.1016/J.Molimm.2017.01.027  0.36
2017 Poli MC, Orange J. Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans Pediatrics. 140: S184-S185. DOI: 10.1542/Peds.2017-2475W  0.302
2017 Poli MC, Orange J. CRISPR/Cas9β-globin Gene Targeting in Human Haematopoietic Stem Cells Pediatrics. 140: S226.2-S227. DOI: 10.1542/Peds.2017-2475Pppp  0.344
2017 Kerbauy LN, Ang S, Liu E, Banerjee PP, Wu Y, Shaim H, Lim FLWI, Basar R, Li L, Muftuoglu M, Daher M, Imahashi N, Mendt MC, Kaplan M, Mukherjee M, ... ... Orange JS, et al. Cord Blood NK Cells Engineered to Express a Humanized CD123-Targeted Chimeric Antigen Receptor (CAR) and IL-15 As Off-the-Shelf Therapy for Acute Myeloid Leukemia Blood. 130: 4453-4453. DOI: 10.1182/Blood.V130.Suppl_1.4453.4453  0.422
2016 Mace EM, Orange JS. Genetic Causes of Human NK Cell Deficiency and Their Effect on NK Cell Subsets. Frontiers in Immunology. 7: 545. PMID 27994588 DOI: 10.3389/Fimmu.2016.00545  0.48
2016 Hsu HT, Mace EM, Carisey AF, Viswanath DI, Christakou AE, Wiklund M, Önfelt B, Orange JS. NK cells converge lytic granules to promote cytotoxicity and prevent bystander killing. The Journal of Cell Biology. PMID 27903610 DOI: 10.1083/Jcb.201604136  0.467
2016 Mace EM, Bigley V, Gunesch JT, Chinn IK, Angelo LS, Care MA, Maisuria S, Keller MD, Togi S, Watkin LB, LaRosa DF, Jhangiani SN, Muzny DM, Stray-Pedersen A, Coban Akdemir Z, ... ... Orange JS, et al. Biallelic mutations in IRF8 impair human NK cell maturation and function. The Journal of Clinical Investigation. PMID 27893462 DOI: 10.1172/Jci86276  0.469
2016 Salzer E, Cagdas D, Hons M, Mace EM, Garncarz W, Petronczki ÖY, Platzer R, Pfajfer L, Bilic I, Ban SA, Willmann KL, Mukherjee M, Supper V, Hsu HT, Banerjee PP, ... ... Orange JS, et al. RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics. Nature Immunology. PMID 27776107 DOI: 10.1038/Ni.3575  0.441
2016 Tangye SG, Pillay B, Randall KL, Avery DT, Phan TG, Gray P, Ziegler JB, Smart JM, Peake J, Arkwright PD, Hambleton S, Orange J, Goodnow CC, Uzel G, Casanova JL, et al. DOCK8-Deficient CD4(+) T Cells are Biased to a Th2 Effector Fate at the Expense of Th1 and Th17 Cells. The Journal of Allergy and Clinical Immunology. PMID 27554822 DOI: 10.1016/J.Jaci.2016.07.016  0.391
2016 Yu H, Zhang VW, Stray-Pedersen A, Hanson IC, Forbes LR, de la Morena MT, Chinn IK, Gorman E, Mendelsohn NJ, Pozos T, Wiszniewski W, Nicholas SK, Yates AB, Moore LE, Berge KE, ... ... Orange JS, et al. Rapid molecular diagnostics of severe primary immunodeficiency determined by using targeted next-generation sequencing. The Journal of Allergy and Clinical Immunology. PMID 27484032 DOI: 10.1016/J.Jaci.2016.05.035  0.363
2016 Kritikou JS, Dahlberg CI, Baptista MA, Wagner AK, Banerjee PP, Gwalani LA, Poli C, Panda SK, Kärre K, Kaech SM, Wermeling F, Andersson J, Orange JS, Brauner H, Westerberg LS. IL-2 in the tumor microenvironment is necessary for Wiskott-Aldrich syndrome protein deficient NK cells to respond to tumors in vivo. Scientific Reports. 6: 30636. PMID 27477778 DOI: 10.1038/Srep30636  0.474
2016 Mace EM, Gunesch JT, Dixon A, Orange JS. Human NK cell development requires CD56-mediated motility and formation of the developmental synapse. Nature Communications. 7: 12171. PMID 27435370 DOI: 10.1038/Ncomms12171  0.457
2016 Hegde M, Mukherjee M, Grada Z, Pignata A, Landi D, Navai SA, Wakefield A, Fousek K, Bielamowicz K, Chow KK, Brawley VS, Byrd TT, Krebs S, Gottschalk S, Wels WS, ... ... Orange JS, et al. Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape. The Journal of Clinical Investigation. PMID 27427982 DOI: 10.1172/Jci83416  0.368
2016 DiNardo AR, Mace EM, Lesteberg K, Cirillo JD, Mandalakas AM, Graviss EA, Orange JS, Makedonas G. Schistosome Soluble Egg Antigen Decreases Mycobacterium tuberculosis-Specific CD4+ T-Cell Effector Function With Concomitant Arrest of Macrophage Phago-Lysosome Maturation. The Journal of Infectious Diseases. 214: 479-88. PMID 27389351 DOI: 10.1093/Infdis/Jiw156  0.309
2016 Mace EM, Orange JS. High- and Super-Resolution Microscopy Imaging of the NK Cell Immunological Synapse. Methods in Molecular Biology (Clifton, N.J.). 1441: 141-50. PMID 27177663 DOI: 10.1007/978-1-4939-3684-7_12  0.411
2016 Vece TJ, Watkin LB, Nicholas SK, Canter D, Braun MC, Guillerman RP, Eldin KW, Bertolet G, McKinley SD, de Guzman M, Forbes LR, Chinn I, Orange JS. Copa Syndrome: a Novel Autosomal Dominant Immune Dysregulatory Disease. Journal of Clinical Immunology. PMID 27048656 DOI: 10.1007/S10875-016-0271-8  0.338
2016 DiNardo AR, Mandalakas AM, Maphalala G, Mtetwa G, Mndzebele T, Ustero P, Hlatshwayo M, Mace EM, Orange JS, Makedonas G. HIV Progression Perturbs the Balance of the Cell-Mediated and Anti-Inflammatory Adaptive and Innate Mycobacterial Immune Response. Mediators of Inflammation. 2016: 1478340. PMID 27006526 DOI: 10.1155/2016/1478340  0.311
2016 Kuehn HS, Boisson B, Cunningham-Rundles C, Reichenbach J, Stray-Pedersen A, Gelfand EW, Maffucci P, Pierce KR, Abbott JK, Voelkerding KV, South ST, Augustine NH, Bush JS, Dolen WK, Wray BB, ... ... Orange JS, et al. Loss of B Cells in Patients with Heterozygous Mutations in IKAROS. The New England Journal of Medicine. 374: 1032-1043. PMID 26981933 DOI: 10.1056/Nejmoa1512234  0.373
2016 Viswanath DI, Mace EM, Hsu HT, Orange JS. Quantification of natural killer cell polarization and visualization of synaptic granule externalization by imaging flow cytometry. Clinical Immunology (Orlando, Fla.). PMID 26948929 DOI: 10.1016/J.Clim.2016.03.004  0.438
2016 Naik S, Nicholas SK, Martinez CA, Leen AM, Hanley PJ, Gottschalk SM, Rooney CM, Hanson IC, Krance RA, Shpall EJ, Cruz CR, Amrolia P, Lucchini G, Bunin N, Heimall J, ... ... Orange JS, et al. Adoptive immunotherapy for primary immunodeficiency disorders with virus-specific T lymphocytes. The Journal of Allergy and Clinical Immunology. PMID 26920464 DOI: 10.1016/J.Jaci.2015.12.1311  0.319
2016 Zilberman-Rudenko J, Shawver LM, Wessel AW, Luo Y, Pelletier M, Tsai WL, Lee Y, Vonortas S, Cheng L, Ashwell JD, Orange JS, Siegel RM, Hanson EP. Recruitment of A20 by the C-terminal domain of NEMO suppresses NF-κB activation and autoinflammatory disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 26802121 DOI: 10.1073/Pnas.1518163113  0.314
2016 Mukherjee M, Mamonkin M, Ahmed N, Brenner M, Orange J. 762. A Quantitative Imaging Tool Box for the Functional Analysis of Chimeric Antigen Receptor - T Cell Immune Synapse Helps Identify Novel Structural and Functional Features of CAR T Cells Molecular Therapy. 24: S301. DOI: 10.1016/S1525-0016(16)33570-5  0.388
2016 Mukherjee M, Navai S, Landi D, Fousek K, Pignata A, Bielamowicz K, Byrd T, Mamonkin M, Hegde M, Brenner MK, Orange JS, Ahmed N. 392. Super-Resolution (STED) Imaging Reveals Simultaneous Co-Docking of Tandem Chimeric Antigen Receptors to Two Target Antigens Enhancing T Cell Functionality and Mitigating Antigen Escape Molecular Therapy. 24: S155-S156. DOI: 10.1016/S1525-0016(16)33201-4  0.362
2016 Silva D, Mukherjee M, Srinivasan M, Orange JS, Brenner MK, Mamonkin M. 210. High Expression of Second Generation CD19 CAR with a 4-1BB Costimulatory Domain from a Retroviral Vector Impairs CAR T Cell Expansion by Enhancing Fas-Mediated Apoptosis Molecular Therapy. 24: S82-S83. DOI: 10.1016/S1525-0016(16)33019-2  0.362
2016 Mamonkin M, Sharma S, Mukherjee M, Srinivasan M, Silva D, Orange JS, Brenner MK. 69. TNFR Costimulatory Domains Impair Expansion of CD5 CAR T Cells Due to Enhanced Fas-Mediated Apoptosis Molecular Therapy. 24: S30. DOI: 10.1016/S1525-0016(16)32878-7  0.341
2016 Brauner H, Kritikou J, Dahlberg C, Baptista M, Wagner A, Kärre K, Orange J, Westerberg L. 410 The role of NK cells in WASp related cancer and eczema: Studies on the pathogenesis and possible novel therapies Journal of Investigative Dermatology. 136: S230. DOI: 10.1016/J.Jid.2016.06.430  0.347
2016 Hegde M, Mukherjee M, Grada Z, Pignata A, Landi D, Wakefield A, Fousek K, Bielamowicz K, Navai S, Chow K, Brawley V, Byrd T, Krebs S, Gottschalk S, Wels W, ... ... Orange J, et al. A Bispecific Chimeric Antigen Receptor Molecule Enhances the Anti-Glioblastoma Efficacy of T Cells Through Dual Immunological Synapse Formation Cytotherapy. 18: S8-S9. DOI: 10.1016/J.Jcyt.2016.03.022  0.335
2016 Yermakova A, Banerjee PB, Watkin LB, Carisey AF, De Los Santos C, Demmler-Harrison GJ, Orange JS. Accessing Natural Killer Cell Antibody-Dependent Cell-Mediated Cytotoxicity Via CMV-Specific Hyperimmune Human Immunoglobulin Journal of Allergy and Clinical Immunology. 137: AB171. DOI: 10.1016/J.Jaci.2015.12.693  0.395
2015 Li YR, Li J, Zhao SD, Bradfield JP, Mentch FD, Maggadottir SM, Hou C, Abrams DJ, Chang D, Gao F, Guo Y, Wei Z, Connolly JJ, Cardinale CJ, Bakay M, ... ... Orange JS, et al. Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases. Nature Medicine. 21: 1018-27. PMID 26301688 DOI: 10.1038/Nm.3933  0.312
2015 Roybal KT, Mace EM, Clark DJ, Leard AD, Herman A, Verkade P, Orange JS, Wülfing C. Modest Interference with Actin Dynamics in Primary T Cell Activation by Antigen Presenting Cells Preferentially Affects Lamellal Signaling. Plos One. 10: e0133231. PMID 26237588 DOI: 10.1371/Journal.Pone.0133231  0.374
2015 Roybal KT, Mace EM, Mantell JM, Verkade P, Orange JS, Wülfing C. Early Signaling in Primary T Cells Activated by Antigen Presenting Cells Is Associated with a Deep and Transient Lamellal Actin Network. Plos One. 10: e0133299. PMID 26237050 DOI: 10.1371/Journal.Pone.0133299  0.375
2015 Mace EM, Orange JS. Insights into primary immune deficiency from quantitative microscopy. The Journal of Allergy and Clinical Immunology. PMID 26078103 DOI: 10.1016/J.Jaci.2015.03.049  0.356
2015 Angelo LS, Banerjee PP, Monaco-Shawver L, Rosen JB, Makedonas G, Forbes LR, Mace EM, Orange JS. Practical NK cell phenotyping and variability in healthy adults. Immunologic Research. 62: 341-56. PMID 26013798 DOI: 10.1007/S12026-015-8664-Y  0.432
2015 Watkin LB, Jessen B, Wiszniewski W, Vece TJ, Jan M, Sha Y, Thamsen M, Santos-Cortez RL, Lee K, Gambin T, Forbes LR, Law CS, Stray-Pedersen A, Cheng MH, Mace EM, ... ... Orange JS, et al. COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis. Nature Genetics. 47: 654-60. PMID 25894502 DOI: 10.1038/Ng.3279  0.328
2015 Li J, Jørgensen SF, Maggadottir SM, Bakay M, Warnatz K, Glessner J, Pandey R, Salzer U, Schmidt RE, Perez E, Resnick E, Goldacker S, Buchta M, Witte T, Padyukov L, ... ... Orange JS, et al. Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells. Nature Communications. 6: 6804. PMID 25891430 DOI: 10.1038/Ncomms7804  0.326
2015 Zheng P, Noroski LM, Hanson IC, Chen Y, Lee ME, Huang Y, Zhu MX, Banerjee PP, Makedonas G, Orange JS, Shearer WT, Liu D. Molecular mechanisms of functional natural killer deficiency in patients with partial DiGeorge syndrome. The Journal of Allergy and Clinical Immunology. 135: 1293-302. PMID 25748067 DOI: 10.1016/J.Jaci.2015.01.011  0.343
2015 Rider NL, Boisson B, Jyonouchi S, Hanson EP, Rosenzweig SD, Cassanova JL, Orange JS. Novel TTC37 Mutations in a Patient with Immunodeficiency without Diarrhea: Extending the Phenotype of Trichohepatoenteric Syndrome. Frontiers in Pediatrics. 3: 2. PMID 25688341 DOI: 10.3389/Fped.2015.00002  0.303
2015 Aydin SE, Kilic SS, Aytekin C, Kumar A, Porras O, Kainulainen L, Kostyuchenko L, Genel F, Kütükcüler N, Karaca N, Gonzalez-Granado L, Abbott J, Al-Zahrani D, Rezaei N, Baz Z, ... ... Orange JS, et al. DOCK8 deficiency: clinical and immunological phenotype and treatment options - a review of 136 patients. Journal of Clinical Immunology. 35: 189-98. PMID 25627830 DOI: 10.1007/S10875-014-0126-0  0.318
2015 Briercheck EL, Trotta R, Chen L, Hartlage AS, Cole JP, Cole TD, Mao C, Banerjee PP, Hsu HT, Mace EM, Ciarlariello D, Mundy-Bosse BL, Garcia-Cao I, Scoville SD, Yu L, ... ... Orange JS, et al. PTEN is a negative regulator of NK cell cytolytic function. Journal of Immunology (Baltimore, Md. : 1950). 194: 1832-40. PMID 25595786 DOI: 10.4049/Jimmunol.1401224  0.463
2015 Tuano KS, Orange JS, Sullivan K, Cunningham-Rundles C, Bonilla FA, Davis CM. Food allergy in patients with primary immunodeficiency diseases: prevalence within the US Immunodeficiency Network (USIDNET). The Journal of Allergy and Clinical Immunology. 135: 273-5. PMID 25441296 DOI: 10.1016/J.Jaci.2014.09.024  0.305
2015 Hegde M, Grada Z, Pignata A, Wakefield A, Fousek K, Bielamowicz K, Chow K, Brawley V, Byrd T, Gottschalk S, Mukherjee M, Wels WS, Baker M, Dotti G, Orange J, et al. A bispecific chimeric antigen receptor molecule enhances T cell activation through dual immunological synapse formation and offsets antigen escape in glioblastoma Journal For Immunotherapy of Cancer. 3. DOI: 10.1186/2051-1426-3-S2-O3  0.325
2015 Liu E, Tong Y, Dotti G, Savoldo B, Muftuoglu M, Kondo K, Mukherjee M, Orange JS, Sobieski C, Alsuliman A, Shaim H, Imahashi N, Keating MJ, Hosing CM, Shah N, et al. Cord Blood Derived Natural Killer Cells Engineered with a Chimeric Antigen Receptor Targeting CD19 and Expressing IL-15 Have Long Term Persistence and Exert Potent Anti-Leukemia Activity Blood. 126: 3091-3091. DOI: 10.1182/Blood.V126.23.3091.3091  0.448
2015 Ferrua F, Cicalese MP, Galimberti S, Scaramuzza S, Giannelli S, Pajno R, Dionisio F, Biasco L, Castiello MC, Casiraghi M, Facchini M, Finocchi A, Metin A, Orange JS, Albert MH, et al. Safety and Clinical Benefit of Lentiviral Hematopoietic Stem Cell Gene Therapy for Wiskott-Aldrich Syndrome Blood. 126: 259-259. DOI: 10.1182/Blood.V126.23.259.259  0.341
2015 Tzannou I, Nicholas SK, Misra A, Katari UL, Orange J, Vera JF, Heslop HE, Rooney CM, Leen AM. Adoptive T-Cell Therapy to Prevent and Treat Human Metapneumovirus (hMPV) Infections Post Hematopoietic Stem Cell Transplant (HSCT) Biology of Blood and Marrow Transplantation. 21: S170. DOI: 10.1016/J.Bbmt.2014.11.248  0.325
2014 Willmann KL, Klaver S, Do?u F, Santos-Valente E, Garncarz W, Bilic I, Mace E, Salzer E, Conde CD, Sic H, Májek P, Banerjee PP, Vladimer GI, Haskolo?lu S, Bolkent MG, ... ... Orange JS, et al. Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity. Nature Communications. 5: 5360. PMID 25406581 DOI: 10.1038/Ncomms6360  0.441
2014 Hsu HT, Orange JS. Distinct integrin-dependent signals define requirements for lytic granule convergence and polarization in natural killer cells. Science Signaling. 7: pe24. PMID 25292212 DOI: 10.1126/Scisignal.2005816  0.43
2014 Kamili QU, Seeborg FO, Saxena K, Nicholas SK, Banerjee PP, Angelo LS, Mace EM, Forbes LR, Martinez C, Wright TS, Orange JS, Hanson IC. Severe cutaneous human papillomavirus infection associated with natural killer cell deficiency following stem cell transplantation for severe combined immunodeficiency. The Journal of Allergy and Clinical Immunology. 134: 1451-1453.e1. PMID 25159470 DOI: 10.1016/J.Jaci.2014.07.009  0.357
2014 Stray-Pedersen A, Jouanguy E, Crequer A, Bertuch AA, Brown BS, Jhangiani SN, Muzny DM, Gambin T, Sorte H, Sasa G, Metry D, Campbell J, Sockrider MM, Dishop MK, Scollard DM, ... ... Orange JS, et al. Compound heterozygous CORO1A mutations in siblings with a mucocutaneous-immunodeficiency syndrome of epidermodysplasia verruciformis-HPV, molluscum contagiosum and granulomatous tuberculoid leprosy. Journal of Clinical Immunology. 34: 871-90. PMID 25073507 DOI: 10.1007/S10875-014-0074-8  0.325
2014 Bayer DK, Martinez CA, Sorte HS, Forbes LR, Demmler-Harrison GJ, Hanson IC, Pearson NM, Noroski LM, Zaki SR, Bellini WJ, Leduc MS, Yang Y, Eng CM, Patel A, Rodningen OK, ... ... Orange JS, et al. Vaccine-associated varicella and rubella infections in severe combined immunodeficiency with isolated CD4 lymphocytopenia and mutations in IL7R detected by tandem whole exome sequencing and chromosomal microarray. Clinical and Experimental Immunology. 178: 459-69. PMID 25046553 DOI: 10.1111/Cei.12421  0.36
2014 Hedayat M, Massaad MJ, Lee YN, Conley ME, Orange JS, Ohsumi TK, Al-Herz W, Notarangelo LD, Geha RS, Chou J. Lessons in gene hunting: a RAG1 mutation presenting with agammaglobulinemia and absence of B cells. The Journal of Allergy and Clinical Immunology. 134: 983-5.e1. PMID 24985406 DOI: 10.1016/J.Jaci.2014.04.037  0.313
2014 Stray-Pedersen A, Backe PH, Sorte HS, Mørkrid L, Chokshi NY, Erichsen HC, Gambin T, Elgstøen KB, Bjørås M, Wlodarski MW, Krüger M, Jhangiani SN, Muzny DM, Patel A, Raymond KM, ... ... Orange JS, et al. PGM3 mutations cause a congenital disorder of glycosylation with severe immunodeficiency and skeletal dysplasia. American Journal of Human Genetics. 95: 96-107. PMID 24931394 DOI: 10.1016/J.Ajhg.2014.05.007  0.332
2014 Zhu S, Phatarpekar PV, Denman CJ, Senyukov VV, Somanchi SS, Nguyen-Jackson HT, Mace EM, Freeman AF, Watowich SS, Orange JS, Holland SM, Lee DA. Transcription of the activating receptor NKG2D in natural killer cells is regulated by STAT3 tyrosine phosphorylation. Blood. 124: 403-11. PMID 24891320 DOI: 10.1182/Blood-2013-05-499707  0.414
2014 Mace EM, Orange JS. Lytic immune synapse function requires filamentous actin deconstruction by Coronin 1A. Proceedings of the National Academy of Sciences of the United States of America. 111: 6708-13. PMID 24760828 DOI: 10.1073/Pnas.1314975111  0.391
2014 Mace EM, Orange JS. Visualization of the immunological synapse by dual color time-gated stimulated emission depletion (STED) nanoscopy. Journal of Visualized Experiments : Jove. PMID 24686478 DOI: 10.3791/51100  0.354
2014 Bassiri H, Das R, Guan P, Barrett DM, Brennan PJ, Banerjee PP, Wiener SJ, Orange JS, Brenner MB, Grupp SA, Nichols KE. iNKT cell cytotoxic responses control T-lymphoma growth in vitro and in vivo . Cancer Immunology Research. 2: 59-69. PMID 24563871 DOI: 10.1158/2326-6066.Cir-13-0104  0.428
2014 Mace EM, Dongre P, Hsu HT, Sinha P, James AM, Mann SS, Forbes LR, Watkin LB, Orange JS. Cell biological steps and checkpoints in accessing NK cell cytotoxicity. Immunology and Cell Biology. 92: 245-55. PMID 24445602 DOI: 10.1038/Icb.2013.96  0.661
2014 Spinner MA, Sanchez LA, Hsu AP, Shaw PA, Zerbe CS, Calvo KR, Arthur DC, Gu W, Gould CM, Brewer CC, Cowen EW, Freeman AF, Olivier KN, Uzel G, Zelazny AM, ... ... Orange JS, et al. GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics, and immunity. Blood. 123: 809-21. PMID 24227816 DOI: 10.1182/Blood-2013-07-515528  0.351
2014 Spinner MA, Odio C, Calvo KR, Hsu AP, Zerbe CS, Cuellar-Rodriguez J, Ker JP, Stoudenmire CJ, Fadare O, Ghosh A, Mace EM, Orange JS, Hickstein DD, Holland SM. Hemophagocytic Lymphohistiocytosis Associated with NK Cell Dysfunction and Disseminated Herpesvirus Infection in GATA2 Deficiency/Monomac Syndrome Blood. 124: 4978-4978. DOI: 10.1182/Blood.V124.21.4978.4978  0.436
2013 Tuli A, Thiery J, James AM, Michelet X, Sharma M, Garg S, Sanborn KB, Orange JS, Lieberman J, Brenner MB. Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity. Molecular Biology of the Cell. 24: 3721-35. PMID 24088571 DOI: 10.1091/Mbc.E13-05-0259  0.78
2013 Orange JS. Natural killer cell deficiency. The Journal of Allergy and Clinical Immunology. 132: 515-25; quiz 526. PMID 23993353 DOI: 10.1016/J.Jaci.2013.07.020  0.476
2013 Aiuti A, Biasco L, Scaramuzza S, Ferrua F, Cicalese MP, Baricordi C, Dionisio F, Calabria A, Giannelli S, Castiello MC, Bosticardo M, Evangelio C, Assanelli A, Casiraghi M, Di Nunzio S, ... ... Orange JS, et al. Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome. Science (New York, N.Y.). 341: 1233151. PMID 23845947 DOI: 10.1126/Science.1233151  0.33
2013 Jyonouchi S, Orange J, Sullivan KE, Krantz I, Deardorff M. Immunologic features of Cornelia de Lange syndrome. Pediatrics. 132: e484-9. PMID 23821697 DOI: 10.1542/Peds.2012-3815  0.376
2013 Hu A, Josephson MB, Diener BL, Nino G, Xu S, Paranjape C, Orange JS, Grunstein MM. Pro-asthmatic cytokines regulate unliganded and ligand-dependent glucocorticoid receptor signaling in airway smooth muscle. Plos One. 8: e60452. PMID 23593222 DOI: 10.1371/Journal.Pone.0060452  0.308
2013 Wang HY, Ma CA, Zhao Y, Fan X, Zhou Q, Edmonds P, Uzel G, Oliveira JB, Orange J, Jain A. Antibody deficiency associated with an inherited autosomal dominant mutation in TWEAK. Proceedings of the National Academy of Sciences of the United States of America. 110: 5127-32. PMID 23493554 DOI: 10.1073/Pnas.1221211110  0.341
2013 McLane LM, Banerjee PP, Cosma GL, Makedonas G, Wherry EJ, Orange JS, Betts MR. Differential localization of T-bet and Eomes in CD8 T cell memory populations Journal of Immunology. 190: 3207-3215. PMID 23455505 DOI: 10.4049/Jimmunol.1201556  0.311
2013 Das R, Bassiri H, Guan P, Wiener S, Banerjee PP, Zhong MC, Veillette A, Orange JS, Nichols KE. The adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation. Blood. 121: 3386-95. PMID 23430111 DOI: 10.1182/Blood-2012-11-468868  0.462
2013 May RM, Okumura M, Hsu CJ, Bassiri H, Yang E, Rak G, Mace EM, Philip NH, Zhang W, Baumgart T, Orange JS, Nichols KE, Kambayashi T. Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function. Blood. 121: 3135-46. PMID 23407547 DOI: 10.1182/Blood-2012-12-474361  0.791
2013 James AM, Hsu HT, Dongre P, Uzel G, Mace EM, Banerjee PP, Orange JS. Rapid activation receptor- or IL-2-induced lytic granule convergence in human natural killer cells requires Src, but not downstream signaling. Blood. 121: 2627-37. PMID 23380740 DOI: 10.1182/Blood-2012-06-437012  0.652
2013 Mizesko MC, Banerjee PP, Monaco-Shawver L, Mace EM, Bernal WE, Sawalle-Belohradsky J, Belohradsky BH, Heinz V, Freeman AF, Sullivan KE, Holland SM, Torgerson TR, Al-Herz W, Chou J, Hanson IC, ... ... Orange JS, et al. Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency. The Journal of Allergy and Clinical Immunology. 131: 840-8. PMID 23380217 DOI: 10.1016/J.Jaci.2012.12.1568  0.497
2013 Mace EM, Hsu AP, Monaco-Shawver L, Makedonas G, Rosen JB, Dropulic L, Cohen JI, Frenkel EP, Bagwell JC, Sullivan JL, Biron CA, Spalding C, Zerbe CS, Uzel G, Holland SM, ... Orange JS, et al. Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56(bright) subset. Blood. 121: 2669-77. PMID 23365458 DOI: 10.1182/Blood-2012-09-453969  0.472
2013 Phatarpekar PV, Mace EM, Orange JS, Freeman AF, Holland SM, Lee DA. NK Cell Deficiency In Job Syndrome Patients With Dominant Negative STAT3 Mutations Blood. 122: 3476-3476. DOI: 10.1182/Blood.V122.21.3476.3476  0.475
2013 Mizesko M, Banerjee P, Monaco-Shawver L, Mace E, Bernal W, Sawalle-Belohradsky J, Belohradsky B, Heinz V, Freeman A, Sullivan K, Holland S, Torgerson T, Al-Herz W, Chou J, Hanson I, ... ... Orange J, et al. A2.23 Impaired Natural Killer Cell Function in DOCK8 Deficiency Annals of the Rheumatic Diseases. 72: A12.3-A13. DOI: 10.1136/Annrheumdis-2013-203215.23  0.501
2013 Saxena K, Nicholas SK, Banerjee P, Seeborg F, Wright T, Martinez C, Orange J, Hanson IC. Disseminated HPV Following Stem Cell Transplant (SCT) in NK(-) Severe Combined Immune Deficiency (SCID) and Association with NK Cell Dysfunction Journal of Allergy and Clinical Immunology. 131: AB232. DOI: 10.1016/J.Jaci.2012.12.1492  0.43
2013 Nicholas SK, Martinez C, Leen A, Rooney C, Bollard C, Gottschalk S, Heslop H, Hanson IC, Brenner M, Orange J. Application of Anti-Viral Adoptive T-Cell Therapy to Primary Immunodeficiency Patients Journal of Allergy and Clinical Immunology. 131: AB139. DOI: 10.1016/J.Jaci.2012.12.1162  0.321
2013 Wang H, Ma CA, Zhao Y, Fan X, Zhou Q, Edmonds P, Uzel G, Oliveria JB, Orange J, Jain A. 273 Cytokine. 63: 308. DOI: 10.1016/J.Cyto.2013.06.276  0.341
2013 Martinez C, Shearer W, Nicholas SK, Orange J, Chinen J, Rosenblatt H, Wu J, Bollard CM, Leung K, Brenner MK, Heslop HE, Hanson IC, Krance RA. B Cell Engraftment in SCID Patients After Stem Cell Transplantation Biology of Blood and Marrow Transplantation. 19: S205-S206. DOI: 10.1016/J.Bbmt.2012.11.228  0.325
2012 Mace EM, Orange JS. New views of the human NK cell immunological synapse: recent advances enabled by super- and high-resolution imaging techniques. Frontiers in Immunology. 3: 421. PMID 23316204 DOI: 10.3389/Fimmu.2012.00421  0.329
2012 Comerci CJ, Mace EM, Banerjee PP, Orange JS. CD2 promotes human natural killer cell membrane nanotube formation. Plos One. 7: e47664. PMID 23112830 DOI: 10.1371/Journal.Pone.0047664  0.381
2012 Mace EM, Wu WW, Ho T, Mann SS, Hsu HT, Orange JS. NK cell lytic granules are highly motile at the immunological synapse and require F-actin for post-degranulation persistence. Journal of Immunology (Baltimore, Md. : 1950). 189: 4870-80. PMID 23066148 DOI: 10.4049/Jimmunol.1201296  0.434
2012 Grier JT, Forbes LR, Monaco-Shawver L, Oshinsky J, Atkinson TP, Moody C, Pandey R, Campbell KS, Orange JS. Human immunodeficiency-causing mutation defines CD16 in spontaneous NK cell cytotoxicity Journal of Clinical Investigation. 122: 3769-3780. PMID 23006327 DOI: 10.1172/Jci64837  0.78
2012 Mace EM, Orange JS. Dual channel STED nanoscopy of lytic granules on actin filaments in natural killer cells. Communicative & Integrative Biology. 5: 184-6. PMID 22808328 DOI: 10.4161/Cib.18818  0.427
2012 Garrett JP, Fung I, Rupon J, Knight A, Mizesko M, Paessler M, Orange JS. Presentation of hemophagocytic lymphohistiocytosis due to a novel MUNC 13-4 mutation masked by partial therapeutic immunosuppression. Pediatric Rheumatology Online Journal. 10: 13. PMID 22554126 DOI: 10.1186/1546-0096-10-13  0.326
2012 Heyward CY, Patel R, Mace EM, Grier JT, Guan H, Makrigiannis AP, Orange JS, Ricciardi RP. Tumorigenic adenovirus 12 cells evade NK cell lysis by reducing the expression of NKG2D ligands. Immunology Letters. 144: 16-23. PMID 22445355 DOI: 10.1016/J.Imlet.2012.03.001  0.797
2012 Orange JS. Unraveling human natural killer cell deficiency. The Journal of Clinical Investigation. 122: 798-801. PMID 22354165 DOI: 10.1172/Jci62620  0.46
2012 Saltzman RW, Monaco-Shawver L, Zhang K, Sullivan KE, Filipovich AH, Orange JS. Novel mutation in STXBP2 prevents IL-2-induced natural killer cell cytotoxicity. The Journal of Allergy and Clinical Immunology. 129: 1666-8. PMID 22336081 DOI: 10.1016/J.Jaci.2011.12.1003  0.365
2012 Carpenter EL, Haglund EA, Mace EM, Deng D, Martinez D, Wood AC, Chow AK, Weiser DA, Belcastro LT, Winter C, Bresler SC, Vigny M, Mazot P, Asgharzadeh S, Seeger RC, ... ... Orange JS, et al. Antibody targeting of anaplastic lymphoma kinase induces cytotoxicity of human neuroblastoma. Oncogene. 31: 4859-67. PMID 22266870 DOI: 10.1038/Onc.2011.647  0.335
2012 van Montfrans JM, Hoepelman AI, Otto S, van Gijn M, van de Corput L, de Weger RA, Monaco-Shawver L, Banerjee PP, Sanders EA, Jol-van der Zijde CM, Betts MR, Orange JS, Bloem AC, Tesselaar K. CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia. The Journal of Allergy and Clinical Immunology. 129: 787-793.e6. PMID 22197273 DOI: 10.1016/J.Jaci.2011.11.013  0.388
2012 Pedroza LA, Kumar V, Sanborn KB, Mace EM, Niinikoski H, Nadeau K, Vasconcelos Dde M, Perez E, Jyonouchi S, Jyonouchi H, Banerjee PP, Ruuskanen O, Condino-Neto A, Orange JS. Autoimmune regulator (AIRE) contributes to Dectin-1-induced TNF-α production and complexes with caspase recruitment domain-containing protein 9 (CARD9), spleen tyrosine kinase (Syk), and Dectin-1. The Journal of Allergy and Clinical Immunology. 129: 464-72, 472.e1-3. PMID 21962774 DOI: 10.1016/J.Jaci.2011.08.027  0.686
2012 Phatarpekar P, Mace E, Orange J, Freeman A, Holland SM, Lee DA. NK Cell Deficiency in Job's Syndrome Patients Blood. 120: 3293-3293. DOI: 10.1182/Blood.V120.21.3293.3293  0.453
2011 Mace EM, Orange JS. Multiple distinct NK-cell synapses. Blood. 118: 6475-6. PMID 22174302 DOI: 10.1182/Blood-2011-10-381392  0.394
2011 Sanborn KB, Mace EM, Rak GD, Difeo A, Martignetti JA, Pecci A, Bussel JB, Favier R, Orange JS. Phosphorylation of the myosin IIA tailpiece regulates single myosin IIA molecule association with lytic granules to promote NK-cell cytotoxicity. Blood. 118: 5862-71. PMID 22123909 DOI: 10.1182/Blood-2011-03-344846  0.804
2011 Rak GD, Mace EM, Banerjee PP, Svitkina T, Orange JS. Natural killer cell lytic granule secretion occurs through a pervasive actin network at the immune synapse. Plos Biology. 9: e1001151. PMID 21931536 DOI: 10.1371/Journal.Pbio.1001151  0.776
2011 Hsu AP, Sampaio EP, Khan J, Calvo KR, Lemieux JE, Patel SY, Frucht DM, Vinh DC, Auth RD, Freeman AF, Olivier KN, Uzel G, Zerbe CS, Spalding C, Pittaluga S, ... ... Orange JS, et al. Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome. Blood. 118: 2653-5. PMID 21670465 DOI: 10.1182/Blood-2011-05-356352  0.337
2011 Orange JS, Roy-Ghanta S, Mace EM, Maru S, Rak GD, Sanborn KB, Fasth A, Saltzman R, Paisley A, Monaco-Shawver L, Banerjee PP, Pandey R. IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function. The Journal of Clinical Investigation. 121: 1535-48. PMID 21383498 DOI: 10.1172/Jci44862  0.798
2011 Kumar V, Pedroza LA, Mace EM, Seeholzer S, Cotsarelis G, Condino-Neto A, Payne AS, Orange JS. The autoimmune regulator (AIRE), which is defective in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy patients, is expressed in human epidermal and follicular keratinocytes and associates with the intermediate filament protein cytokeratin 17. The American Journal of Pathology. 178: 983-8. PMID 21356351 DOI: 10.1016/J.Ajpath.2010.12.007  0.355
2011 Monaco-Shawver L, Schwartz L, Tuluc F, Guo CJ, Lai JP, Gunnam SM, Kilpatrick LE, Banerjee PP, Douglas SD, Orange JS. Substance P inhibits natural killer cell cytotoxicity through the neurokinin-1 receptor. Journal of Leukocyte Biology. 89: 113-25. PMID 20940324 DOI: 10.1189/Jlb.0410200  0.446
2011 Keller M, Paessler M, Orange J. Approximation of Splenic NK and Dendritic Cells in Perforin-Deficient Hemophagocytic Syndrome: Insights into Pathogenesis Journal of Allergy and Clinical Immunology. 127: AB90-AB90. DOI: 10.1016/J.Jaci.2010.12.362  0.406
2011 Saltzman R, Monaco-Shawver L, Sullivan K, Orange J. Novel Mutation in Syntaxin-Binding Protein 2 (STXBP2) in Familial Hemophagocytic Lymphohistiocytosis Type 5 (FHL-5) Prevents IL-2-induced Natural Killer Cell Cytotoxicity and Degranulation Journal of Allergy and Clinical Immunology. 127: AB89-AB89. DOI: 10.1016/J.Jaci.2010.12.359  0.363
2010 Boztug K, Schmidt M, Schwarzer A, Banerjee PP, Díez IA, Dewey RA, Böhm M, Nowrouzi A, Ball CR, Glimm H, Naundorf S, Kühlcke K, Blasczyk R, Kondratenko I, Maródi L, ... Orange JS, et al. Stem-cell gene therapy for the Wiskott-Aldrich syndrome. The New England Journal of Medicine. 363: 1918-27. PMID 21067383 DOI: 10.1056/Nejmoa1003548  0.387
2010 Yatherajam G, Banerjee PP, McCorkell KA, Solt LA, Hanson EP, Madge LA, Kang S, Worley PF, Orange JS, May MJ. Cutting edge: association with I kappa B kinase beta regulates the subcellular localization of Homer3. Journal of Immunology (Baltimore, Md. : 1950). 185: 2665-9. PMID 20693425 DOI: 10.4049/Jimmunol.0903488  0.349
2010 Wang HY, Gopalan V, Aksentijevich I, Yeager M, Ma CA, Mohamoud YA, Quinones M, Matthews C, Boland J, Niemela JE, Torgerson TR, Giliani S, Uzel G, Orange JS, Shapiro R, et al. A custom 148 gene-based resequencing chip and the SNP explorer software: new tools to study antibody deficiency. Human Mutation. 31: 1080-8. PMID 20652909 DOI: 10.1002/Humu.21322  0.304
2010 Orange JS. Latent herpesviruses: aligning human and murine NK cells. Blood. 115: 4321-2. PMID 20522715 DOI: 10.1182/Blood-2010-03-271361  0.454
2010 Mentlik AN, Sanborn KB, Holzbaur EL, Orange JS. Rapid lytic granule convergence to the MTOC in natural killer cells is dependent on dynein but not cytolytic commitment. Molecular Biology of the Cell. 21: 2241-56. PMID 20444980 DOI: 10.1091/Mbc.E09-11-0930  0.689
2010 Yong PL, Orange JS, Sullivan KE. Pediatric common variable immunodeficiency: immunologic and phenotypic associations with switched memory B cells. Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology. 21: 852-8. PMID 20337966 DOI: 10.1111/J.1399-3038.2010.01004.X  0.335
2010 Sanborn KB, Orange JS. Navigating barriers: the challenge of directed secretion at the natural killer cell lytic immunological synapse. Journal of Clinical Immunology. 30: 358-63. PMID 20191315 DOI: 10.1007/S10875-010-9372-Y  0.726
2010 Banerjee PP, Orange JS. Quantitative measurement of F-actin accumulation at the NK cell immunological synapse. Journal of Immunological Methods. 355: 1-13. PMID 20171970 DOI: 10.1016/J.Jim.2010.02.003  0.424
2010 Sanborn KB, Rak GD, Mentlik AN, Banerjee PP, Orange JS. Analysis of the NK cell immunological synapse. Methods in Molecular Biology (Clifton, N.J.). 612: 127-48. PMID 20033638 DOI: 10.1007/978-1-60761-362-6_9  0.798
2010 Boztug K, Schmidt M, Schwarzer A, Banerjee P, Böhm M, Beier R, Díez IA, Dewey R, Ball CR, Nowrouzi A, Naundorf S, Küuhlcke K, Blasczyk R, Rose M, Fraser C, ... ... Orange J, et al. Correction of Wiskott-Aldrich Syndrome by Hematopoietic Stem Cell Gene Therapy Blood. 116: 5-5. DOI: 10.1182/Blood.V116.21.5.5  0.4
2009 Savic V, Sanborn KB, Orange JS, Bassing CH. Chipping away at gamma-H2AX foci. Cell Cycle (Georgetown, Tex.). 8: 3285-90. PMID 19770593 DOI: 10.4161/Cc.8.20.9719  0.62
2009 Sanborn KB, Rak GD, Maru SY, Demers K, Difeo A, Martignetti JA, Betts MR, Favier R, Banerjee PP, Orange JS. Myosin IIA associates with NK cell lytic granules to enable their interaction with F-actin and function at the immunological synapse. Journal of Immunology (Baltimore, Md. : 1950). 182: 6969-84. PMID 19454694 DOI: 10.4049/Jimmunol.0804337  0.798
2009 Pien GC, Basner-Tschakarjan E, Hui DJ, Mentlik AN, Finn JD, Hasbrouck NC, Zhou S, Murphy SL, Maus MV, Mingozzi F, Orange JS, High KA. Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors. The Journal of Clinical Investigation. 119: 1688-95. PMID 19436115 DOI: 10.1172/Jci36891  0.32
2009 Makedonas G, Banerjee PP, Pandey R, Hersperger AR, Sanborn KB, Hardy GA, Orange JS, Betts MR. Rapid up-regulation and granule-independent transport of perforin to the immunological synapse define a novel mechanism of antigen-specific CD8+ T cell cytotoxic activity. Journal of Immunology (Baltimore, Md. : 1950). 182: 5560-9. PMID 19380804 DOI: 10.4049/Jimmunol.0803945  0.696
2009 Heltzer ML, Coffin SE, Maurer K, Bagashev A, Zhang Z, Orange JS, Sullivan KE. Immune dysregulation in severe influenza. Journal of Leukocyte Biology. 85: 1036-43. PMID 19276177 DOI: 10.1189/Jlb.1108710  0.303
2009 Fish JD, Duerst RE, Gelfand EW, Orange JS, Bunin N. Challenges in the use of allogeneic hematopoietic SCT for ectodermal dysplasia with immune deficiency Bone Marrow Transplantation. 43: 217-221. PMID 18794870 DOI: 10.1038/Bmt.2008.308  0.34
2009 Abraham V, Jyonouchi S, Nichols K, Spergel J, Orange J, Cianferoni A. Milk-Derived Glycoshingolipids (GSL) Specifically Ligate The Invariant NKT Cell (iNKT) T Cell Receptor (TCR), Induce iNKT Proliferation And Promote Th2 Cytokine Expression Journal of Allergy and Clinical Immunology. 123: 724. DOI: 10.1016/J.Jaci.2009.01.005  0.374
2009 Pandey R, Kumar V, Banerjee O, Orange J. Rapidly NF-κB-dependent Synthesis Contributes To NK Cell Function And Is Defective In Nk Cells With Hypomorphic Nemo Mutation Journal of Allergy and Clinical Immunology. 123: S148-S148. DOI: 10.1016/J.Jaci.2008.12.554  0.427
2009 Min S, Monaco-Shawver L, Orange J, Church J. T.36. Classical Natural Killer Cell Deficiency (CNKD): A New Case Clinical Immunology. 131: S61. DOI: 10.1016/J.Clim.2009.03.177  0.337
2008 Orange JS. Formation and function of the lytic NK-cell immunological synapse. Nature Reviews. Immunology. 8: 713-25. PMID 19172692 DOI: 10.1038/Nri2381  0.457
2008 Pai SY, Levy O, Jabara HH, Glickman JN, Stoler-Barak L, Sachs J, Nurko S, Orange JS, Geha RS. Allogeneic transplantation successfully corrects immune defects, but not susceptibility to colitis, in a patient with nuclear factor-kappaB essential modulator deficiency. The Journal of Allergy and Clinical Immunology. 122: 1113-1118.e1. PMID 18851875 DOI: 10.1016/J.Jaci.2008.08.026  0.3
2008 Hanson EP, Monaco-Shawver L, Solt LA, Madge LA, Banerjee PP, May MJ, Orange JS. Hypomorphic nuclear factor-kappaB essential modulator mutation database and reconstitution system identifies phenotypic and immunologic diversity. The Journal of Allergy and Clinical Immunology. 122: 1169-1177.e16. PMID 18851874 DOI: 10.1016/J.Jaci.2008.08.018  0.365
2008 Perez EE, Wang J, Miller JC, Jouvenot Y, Kim KA, Liu O, Wang N, Lee G, Bartsevich VV, Lee YL, Guschin DY, Rupniewski I, Waite AJ, Carpenito C, Carroll RG, ... Orange JS, et al. Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases. Nature Biotechnology. 26: 808-16. PMID 18587387 DOI: 10.1038/Nbt1410  0.302
2008 Suhoski MM, Perez EE, Heltzer ML, Laney A, Shaffer LG, Saitta S, Nachman S, Spinner NB, June CH, Orange JS. Monosomy 1p36 uncovers a role for OX40 in survival of activated CD4+ T cells. Clinical Immunology (Orlando, Fla.). 128: 181-9. PMID 18511345 DOI: 10.1016/J.Clim.2008.03.522  0.369
2008 Madge LA, Kluger MS, Orange JS, May MJ. Lymphotoxin-alpha 1 beta 2 and LIGHT induce classical and noncanonical NF-kappa B-dependent proinflammatory gene expression in vascular endothelial cells. Journal of Immunology (Baltimore, Md. : 1950). 180: 3467-77. PMID 18292573 DOI: 10.4049/Jimmunol.180.5.3467  0.33
2008 LaRosa DF, Orange JS. 1. Lymphocytes Journal of Allergy and Clinical Immunology. 121. PMID 18241683 DOI: 10.1016/j.jaci.2007.06.016  0.309
2008 Salt BH, Niemela JE, Pandey R, Hanson EP, Deering RP, Quinones R, Jain A, Orange JS, Gelfand EW. IKBKG (nuclear factor-kappa B essential modulator) mutation can be associated with opportunistic infection without impairing Toll-like receptor function. The Journal of Allergy and Clinical Immunology. 121: 976-82. PMID 18179816 DOI: 10.1016/J.Jaci.2007.11.014  0.302
2008 ROYGHANTA S, MARU S, ISACOF O, ORANGE J. Interleukin-2 Directly Enhances Natural Killer Cell F-actin Reorganization in a Wiskott-Aldrich Syndrome in-vitro Model Journal of Allergy and Clinical Immunology. 121: S83-S83. DOI: 10.1016/J.Jaci.2007.12.330  0.353
2008 SPERGEL J, BOGUNIEWICZ M, ORANGE J, PINZONE K, LEUNG S, HARBECK R, LEUNG D. CLA+T Cells Play an Important Role in the Atopic March (AM) Journal of Allergy and Clinical Immunology. 121: S34-S34. DOI: 10.1016/J.Jaci.2007.12.140  0.321
2008 SHAWVER L, GUO J, LAI J, LI H, KILPATRICK L, DOUGLAS S, ORANGE J. Inhibitory Effect of Substance P via NK-1R Tachykinin Receptor on NK Cell Function Journal of Allergy and Clinical Immunology. 121: S13-S13. DOI: 10.1016/J.Jaci.2007.12.053  0.353
2007 Pandey R, DeStephan CM, Madge LA, May MJ, Orange JS. NKp30 ligation induces rapid activation of the canonical NF-kappaB pathway in NK cells. Journal of Immunology (Baltimore, Md. : 1950). 179: 7385-96. PMID 18025182 DOI: 10.4049/Jimmunol.179.11.7385  0.422
2007 Andzelm MM, Chen X, Krzewski K, Orange JS, Strominger JL. Myosin IIA is required for cytolytic granule exocytosis in human NK cells. The Journal of Experimental Medicine. 204: 2285-91. PMID 17875677 DOI: 10.1084/Jem.20071143  0.448
2007 Banerjee PP, Pandey R, Zheng R, Suhoski MM, Monaco-Shawver L, Orange JS. Cdc42-interacting protein-4 functionally links actin and microtubule networks at the cytolytic NK cell immunological synapse. The Journal of Experimental Medicine. 204: 2305-20. PMID 17785506 DOI: 10.1084/Jem.20061893  0.415
2007 Orange JS. The lytic NK cell immunological synapse and sequential steps in its formation. Advances in Experimental Medicine and Biology. 601: 225-33. PMID 17713009 DOI: 10.1007/978-0-387-72005-0_23  0.369
2007 Orange JS. The lytic NK cell immunological synapse and sequential steps in its formation. Advances in Experimental Medicine and Biology. 601: 225-33. PMID 17713009 DOI: 10.1007/978-0-387-72005-0_23  0.369
2007 Onigbanjo MT, Orange JS, Perez EE, Sullivan KE. Hypogammaglobulinemia in a pediatric tertiary care setting. Clinical Immunology (Orlando, Fla.). 125: 52-9. PMID 17631052 DOI: 10.1016/J.Clim.2007.05.017  0.314
2007 Veler H, Hu A, Fatma S, Grunstein JS, DeStephan CM, Campbell D, Orange JS, Grunstein MM. Superantigen presentation by airway smooth muscle to CD4+ T lymphocytes elicits reciprocal proasthmatic changes in airway function. Journal of Immunology (Baltimore, Md. : 1950). 178: 3627-36. PMID 17339460 DOI: 10.4049/Jimmunol.178.6.3627  0.374
2007 Chang JT, Palanivel VR, Kinjyo I, Schambach F, Intlekofer AM, Banerjee A, Longworth SA, Vinup KE, Mrass P, Oliaro J, Killeen N, Orange JS, Russell SM, Weninger W, Reiner SL. Asymmetric T lymphocyte division in the initiation of adaptive immune responses. Science (New York, N.Y.). 315: 1687-91. PMID 17332376 DOI: 10.1126/Science.1139393  0.408
2006 Dorsey MJ, Orange JS. Impaired specific antibody response and increased B-cell population in transient hypogammaglobulinemia of infancy Annals of Allergy, Asthma and Immunology. 97: 590-595. PMID 17165264 DOI: 10.1016/S1081-1206(10)61085-X  0.304
2006 Orange JS. Human natural killer cell deficiencies Current Opinion in Allergy and Clinical Immunology. 6: 399-409. PMID 17088643 DOI: 10.1097/Aci.0B013E3280106B65  0.434
2006 Krzewski K, Chen X, Orange JS, Strominger JL. Formation of a WIP-, WASp-, actin-, and myosin IIA-containing multiprotein complex in activated NK cells and its alteration by KIR inhibitory signaling. The Journal of Cell Biology. 173: 121-32. PMID 16606694 DOI: 10.1083/Jcb.200509076  0.423
2006 Deering RP, Orange JS. Development of a clinical assay to evaluate toll-like receptor function. Clinical and Vaccine Immunology : Cvi. 13: 68-76. PMID 16426002 DOI: 10.1128/Cvi.13.1.68-76.2006  0.334
2006 Orange JS, Ballas ZK. Natural killer cells in human health and disease Clinical Immunology. 118: 1-10. PMID 16337194 DOI: 10.1016/J.Clim.2005.10.011  0.429
2006 Pandey R, Deering R, Kienzle M, Banerjee P, Orange J. Requirement for the Classical Pathway of NF-kB Activation in NK Cell Cytotolytic Function Journal of Allergy and Clinical Immunology. 117: S15. DOI: 10.1016/J.Jaci.2005.12.063  0.396
2005 Intlekofer AM, Takemoto N, Wherry EJ, Longworth SA, Northrup JT, Palanivel VR, Mullen AC, Gasink CR, Kaech SM, Miller JD, Gapin L, Ryan K, Russ AP, Lindsten T, Orange JS, et al. Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nature Immunology. 6: 1236-44. PMID 16273099 DOI: 10.1038/Ni1268  0.343
2005 Orange JS, Levy O, Geha RS. Human disease resulting from gene mutations that interfere with appropriate nuclear factor-kappaB activation. Immunological Reviews. 203: 21-37. PMID 15661019 DOI: 10.1111/J.0105-2896.2005.00221.X  0.312
2004 Jain A, Ma CA, Lopez-Granados E, Means G, Brady W, Orange JS, Liu S, Holland S, Derry JMJ. Specific NEMO mutations impair CD40-mediated c-Rel activation and B cell terminal differentiation Journal of Clinical Investigation. 114: 1593-1602. PMID 15578091 DOI: 10.1172/Jci21345  0.371
2004 Orange JS, Stone KD, Turvey SE, Krzewski K. The Wiskott-Aldrich syndrome Cellular and Molecular Life Sciences. 61: 2361-2385. PMID 15378206 DOI: 10.1007/S00018-004-4086-Z  0.401
2004 Li Y, Zhang T, Ho C, Orange JS, Douglas SD, Ho WZ. Natural killer cells inhibit hepatitis C virus expression Journal of Leukocyte Biology. 76: 1171-1179. PMID 15339939 DOI: 10.1189/Jlb.0604372  0.361
2004 Orange JS, Jain A, Ballas ZK, Schneider LC, Geha RS, Bonilla FA. The presentation and natural history of immunodeficiency caused by nuclear factor kappaB essential modulator mutation. The Journal of Allergy and Clinical Immunology. 113: 725-33. PMID 15100680 DOI: 10.1016/J.Jaci.2004.01.762  0.304
2003 Orange JS, Harris KE, Andzelm MM, Valter MM, Geha RS, Strominger JL. The mature activating natural killer cell immunologic synapse is formed in distinct stages. Proceedings of the National Academy of Sciences of the United States of America. 100: 14151-6. PMID 14612578 DOI: 10.1073/Pnas.1835830100  0.415
2003 Koopman LA, Kopcow HD, Rybalov B, Boyson JE, Orange JS, Schatz F, Masch R, Lockwood CJ, Schachter AD, Park PJ, Strominger JL. Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential. The Journal of Experimental Medicine. 198: 1201-12. PMID 14568979 DOI: 10.1084/Jem.20030305  0.384
2003 Levy O, Orange JS, Hibberd P, Steinberg S, LaRussa P, Weinberg A, Wilson SB, Shaulov A, Fleisher G, Geha RS, Bonilla FA, Exley M. Disseminated varicella infection due to the vaccine strain of varicella-zoster virus, in a patient with a novel deficiency in natural killer T cells. The Journal of Infectious Diseases. 188: 948-53. PMID 14513412 DOI: 10.1086/378503  0.317
2003 Orange JS, Geha RS, Bonilla FA. Acute chylothorax in children: selective retention of memory T cells and natural killer cells. The Journal of Pediatrics. 143: 243-9. PMID 12970641 DOI: 10.1067/S0022-3476(03)00305-6  0.332
2002 Orange JS. Human natural killer cell deficiencies and susceptibility to infection Microbes and Infection. 4: 1545-1558. PMID 12505527 DOI: 10.1016/S1286-4579(02)00038-2  0.466
2002 Orange JS, Fassett MS, Koopman LA, Boyson JE, Strominger JL. Viral evasion of natural killer cells. Nature Immunology. 3: 1006-12. PMID 12407408 DOI: 10.1038/Ni1102-1006  0.402
2002 Orange JS, Ramesh N, Remold-O'Donnell E, Sasahara Y, Koopman L, Byrne M, Bonilla FA, Rosen FS, Geha RS, Strominger JL. Wiskott-Aldrich syndrome protein is required for NK cell cytotoxicity and colocalizes with actin to NK cell-activating immunologic synapses. Proceedings of the National Academy of Sciences of the United States of America. 99: 11351-6. PMID 12177428 DOI: 10.1073/Pnas.162376099  0.478
2002 Orange JS, Brodeur SR, Jain A, Bonilla FA, Schneider LC, Kretschmer R, Nurko S, Rasmussen WL, Köhler JR, Gellis SE, Ferguson BM, Strominger JL, Zonana J, Ramesh N, Ballas ZK, et al. Deficient natural killer cell cytotoxicity in patients with IKK-gamma/NEMO mutations. The Journal of Clinical Investigation. 109: 1501-9. PMID 12045264 DOI: 10.1172/Jci14858  0.444
2001 Orange JS, Chehimi J, Ghavimi D, Campbell D, Sullivan KE. Decreased natural killer (NK) cell function in chronic NK cell lymphocytosis associated with decreased surface expression of CD11b Clinical Immunology. 99: 53-64. PMID 11286541 DOI: 10.1006/Clim.2001.5002  0.388
1998 Salazar-Mather TP, Orange JS, Biron CA. Early murine cytomegalovirus (MCMV) infection induces liver natural killer (NK) cell inflammation and protection through macrophage inflammatory protein 1α (MIP-1α)-dependent pathways Journal of Experimental Medicine. 187: 1-14. PMID 9419206 DOI: 10.1084/Jem.187.1.1  0.341
1997 Orange JS, Salazar-Mather TP, Opal SM, Biron CA. Mechanisms for virus-induced liver disease: Tumor necrosis factor- mediated pathology independent of natural killer and T cells during murine cytomegalovirus infection Journal of Virology. 71: 9248-9258. PMID 9371583 DOI: 10.1128/Jvi.71.12.9248-9258.1997  0.329
1996 Biron CA, Su HC, Orange JS. Function and regulation of natural killer (NK) cells during viral infections: Characterization of responses in vivo Methods: a Companion to Methods in Enzymology. 9: 379-393. DOI: 10.1006/Meth.1996.0043  0.433
1995 Orange JS, Wang B, Terhorst C, Biron CA. Requirement for natural killer cell-produced interferon γ in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration Journal of Experimental Medicine. 182: 1045-1056. PMID 7561678 DOI: 10.1084/Jem.182.4.1045  0.435
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