Jordan S. Orange - Publications

Affiliations: 
Cell and Molecular Biology University of Pennsylvania, Philadelphia, PA, United States 
Area:
Immunology

229 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Lam MT, Coppola S, Krumbach OHF, Prencipe G, Insalaco A, Cifaldi C, Brigida I, Zara E, Scala S, Di Cesare S, Martinelli S, Di Rocco M, Pascarella A, Niceta M, Pantaleoni F, ... ... Orange JS, et al. A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function. The Journal of Experimental Medicine. PMID 31601675 DOI: 10.1084/jem.20190147  0.32
2019 Vargas-Hernández A, Witalisz-Siepracka A, Prchal-Murphy M, Klein K, Mahapatra S, Al-Herz W, Mace EM, Carisey AF, Orange JS, Sexl V, Forbes LR. Human STAT5b mutation causes dysregulated human natural killer cell maturation and impaired lytic function. The Journal of Allergy and Clinical Immunology. PMID 31600547 DOI: 10.1016/j.jaci.2019.09.016  0.32
2019 Serwas NK, Hoeger B, Ardy RC, Stulz SV, Sui Z, Memaran N, Meeths M, Krolo A, Petronczki ÖY, Pfajfer L, Hou TZ, Halliday N, Santos-Valente E, Kalinichenko A, Kennedy A, ... ... Orange JS, et al. Publisher Correction: Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis. Nature Communications. 10: 4555. PMID 31578334 DOI: 10.1038/s41467-019-12454-5  0.6
2019 Burk CM, Coffey KE, Mace EM, Bostwick BL, Chinn IK, Coban-Akdemir ZH, Jhangiani SN, Lupski JR, Ortiz D, Barnum JL, Allen SW, Robertson LM, Orange JS, Chong HJ. Immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome with NK dysfunction and EBV-driven malignancy treated with stem cell transplantation. The Journal of Allergy and Clinical Immunology. in Practice. PMID 31520839 DOI: 10.1016/j.jaip.2019.08.040  0.32
2019 Aird A, Lagos M, Vargas-Hernández A, Posey JE, Coban-Akdemir Z, Jhangiani S, Mace EM, Reyes A, King A, Cavagnaro F, Forbes LR, Chinn IK, Lupski JR, Orange JS, Poli MC. Novel Heterozygous Mutation in Is Associated With Early Onset CVID and a Functional Defect in NK Cells Complicated by Disseminated CMV Infection and Severe Nephrotic Syndrome. Frontiers in Pediatrics. 7: 303. PMID 31417880 DOI: 10.3389/fped.2019.00303  0.32
2019 Serwas NK, Hoeger B, Ardy RC, Stulz SV, Sui Z, Memaran N, Meeths M, Krolo A, Yüce Petronczki Ö, Pfajfer L, Hou TZ, Halliday N, Santos-Valente E, Kalinichenko A, Kennedy A, ... ... Orange JS, et al. Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis. Nature Communications. 10: 3106. PMID 31308374 DOI: 10.1038/s41467-019-10812-x  0.6
2019 Chaimowitz NS, Branch J, Reyes A, Vargas-Hernández A, Orange JS, Forbes LR, Ehlayel M, Purayil SC, Al-Nesf MA, Vogel TP. A Novel Mutation in a Qatari Patient With Hyper-IgE Syndrome. Frontiers in Pediatrics. 7: 130. PMID 31069200 DOI: 10.3389/fped.2019.00130  0.32
2019 Alfayez M, Wang SA, Bannon SA, Kontoyiannis DP, Kornblau SM, Orange JS, Mace EM, DiNardo CD. Myeloid malignancies with somatic GATA2 mutations can be associated with an immunodeficiency phenotype. Leukemia & Lymphoma. 1-9. PMID 30648453 DOI: 10.1080/10428194.2018.1551535  0.32
2019 Mace EM, Orange JS. Emerging insights into human health and NK cell biology from the study of NK cell deficiencies. Immunological Reviews. 287: 202-225. PMID 30565241 DOI: 10.1111/imr.12725  0.32
2018 Staines Boone AT, Chinn IK, Alaez-Versón C, Yamazaki-Nakashimada MA, Carrillo-Sánchez K, García-Cruz MLH, Poli MC, González Serrano ME, Medina Torres EA, Muzquiz Zermeño D, Forbes LR, Espinosa-Rosales FJ, Espinosa-Padilla SE, Orange JS, Lugo Reyes SO. Failing to Make Ends Meet: The Broad Clinical Spectrum of DNA Ligase IV Deficiency. Case Series and Review of the Literature. Frontiers in Pediatrics. 6: 426. PMID 30719430 DOI: 10.3389/fped.2018.00426  0.32
2018 Gunesch JT, Angelo LS, Mahapatra S, Deering RP, Kowalko JE, Sleiman P, Tobias JW, Monaco-Shawver L, Orange JS, Mace EM. Genome-wide analyses and functional profiling of human NK cell lines. Molecular Immunology. PMID 30054012 DOI: 10.1016/j.molimm.2018.07.015  0.32
2018 Gunesch JT, Angelo LS, Mahapatra S, Deering RP, Kowalko JE, Sleiman P, Tobias JW, Monaco-Shawver L, Orange JS, Mace EM. Genome-wide analyses and functional profiling of human NK cell lines. Molecular Immunology. PMID 30054012 DOI: 10.1016/j.molimm.2018.07.015  0.32
2018 Orange JS, Mace EM, French AR, Yokoyama WM, Fehniger TA, Cooper MA. Comment on: Evidence of innate lymphoid cell redundancy in humans. Nature Immunology. 19: 788-789. PMID 30026477 DOI: 10.1038/s41590-018-0164-5  0.32
2018 Poli MC, Ebstein F, Nicholas SK, de Guzman MM, Forbes LR, Chinn IK, Mace EM, Vogel TP, Carisey AF, Benavides F, Coban-Akdemir ZH, Gibbs RA, Jhangiani SN, Muzny DM, Carvalho CMB, ... ... Orange JS, et al. Heterozygous Truncating Variants in POMP Escape Nonsense-Mediated Decay and Cause a Unique Immune Dysregulatory Syndrome. American Journal of Human Genetics. PMID 29805043 DOI: 10.1016/j.ajhg.2018.04.010  0.32
2018 Mace EM, Orange JS. Discovering the Cause of Wiskott-Aldrich Syndrome and Laying the Foundation for Understanding Immune Cell Structuring. Journal of Immunology (Baltimore, Md. : 1950). 200: 3667-3670. PMID 29784762 DOI: 10.4049/jimmunol.1800518  0.32
2018 DiNardo AR, Nishiguchi T, Mace EM, Rajapakshe K, Mtetwa G, Kay A, Maphalala G, Secor WE, Mejia R, Orange JS, Coarfa C, Bhalla KN, Graviss EA, Mandalakas AM, Makedonas G. Schistosomiasis Induces Persistent DNA Methylation and Tuberculosis-Specific Immune Changes. Journal of Immunology (Baltimore, Md. : 1950). PMID 29752313 DOI: 10.4049/jimmunol.1800101  0.32
2018 Chinn IK, Eckstein OS, Peckham-Gregory EC, Goldberg BR, Forbes LR, Nicholas SK, Mace EM, Vogel TP, Abhyankar HA, Diaz MI, Heslop HE, Krance RA, Martinez CA, Nguyen TC, Bashir DA, ... ... Orange JS, et al. Genetic and mechanistic diversity in pediatric hemophagocytic lymphohistiocytosis. Blood. PMID 29632024 DOI: 10.1182/blood-2017-11-814244  0.32
2018 Yanir AD, Hanson IC, Shearer WT, Noroski LM, Forbes LR, Seeborg FO, Nicholas S, Chinn I, Orange JS, Rider NL, Leung KS, Naik S, Carrum G, Sasa G, Hegde M, et al. High Incidence of Autoimmune Disease Post HSCT for Chronic Granulomatous Disease. Biology of Blood and Marrow Transplantation : Journal of the American Society For Blood and Marrow Transplantation. PMID 29630926 DOI: 10.1016/j.bbmt.2018.03.029  0.32
2018 Carisey AF, Mace EM, Saeed MB, Davis DM, Orange JS. Nanoscale Dynamism of Actin Enables Secretory Function in Cytolytic Cells. Current Biology : Cb. PMID 29398219 DOI: 10.1016/j.cub.2017.12.044  0.32
2018 Ruiz-García R, Vargas-Hernandez A, Chinn IK, Angelo LS, Cao TN, Coban-Akdemir Z, Jhangiani SN, Meng Q, Forbes LR, Muzny DM, Allende LM, Ehlayel MS, Gibbs RA, Lupski JR, Uzel G, ... Orange JS, et al. Mutations in PI3K110δ cause impaired NK cell function partially rescued by rapamycin treatment. The Journal of Allergy and Clinical Immunology. PMID 29330011 DOI: 10.1016/j.jaci.2017.11.042  0.32
2017 Vargas-Hernandez A, Mace EM, Zimmerman O, Zerbe CS, Freeman AF, Rosenzweig S, Leiding JW, Torgerson T, Altman MC, Schussler E, Cunningham-Rundles C, Chinn IK, Carisey AF, Hanson IC, Rider NL, ... ... Orange JS, et al. Ruxolitinib partially reverses functional NK cell deficiency in patients with STAT1 gain-of-function mutations. The Journal of Allergy and Clinical Immunology. PMID 29111217 DOI: 10.1016/j.jaci.2017.08.040  0.32
2017 Mahapatra S, Mace EM, Minard CG, Forbes LR, Vargas-Hernandez A, Duryea TK, Makedonas G, Banerjee PP, Shearer WT, Orange JS. High-resolution phenotyping identifies NK cell subsets that distinguish healthy children from adults. Plos One. 12: e0181134. PMID 28767726 DOI: 10.1371/journal.pone.0181134  0.6
2017 Pal M, Schwab L, Yermakova A, Mace EM, Claus R, Krahl AC, Woiterski J, Hartwig UF, Orange JS, Handgretinger R, André MC. Tumor-priming converts NK cells to memory-like NK cells. Oncoimmunology. 6: e1317411. PMID 28680749 DOI: 10.1080/2162402X.2017.1317411  0.32
2017 Mukherjee M, Mace EM, Carisey AF, Ahmed N, Orange JS. Quantitative Imaging Approaches to Study the CAR Immunological Synapse. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 28663103 DOI: 10.1016/j.ymthe.2017.06.003  0.32
2017 Samson EB, Tsao DS, Zimak J, McLaughlin RT, Trenton NJ, Mace EM, Orange JS, Schweikhard V, Diehl MR. The coordinating role of IQGAP1 in the regulation of local, endosome-specific actin networks. Biology Open. PMID 28455356 DOI: 10.1242/bio.022624  0.32
2017 Hsu HT, Carisey AF, Orange JS. Measurement of Lytic Granule Convergence After Formation of an NK Cell Immunological Synapse. Methods in Molecular Biology (Clifton, N.J.). 1584: 497-515. PMID 28255722 DOI: 10.1007/978-1-4939-6881-7_31  0.32
2017 Pedroza LA, Guerrero N, Stray-Pedersen A, Tafur C, Macias R, Muñoz G, Akdemir ZC, Jhangiani SN, Watkin LB, Chinn IK, Lupski JR, Orange JS. First Case of CD40LG Deficiency in Ecuador, Diagnosed after Whole Exome Sequencing in a Patient with Severe Cutaneous Histoplasmosis. Frontiers in Pediatrics. 5: 17. PMID 28239602 DOI: 10.3389/fped.2017.00017  0.32
2016 Mace EM, Orange JS. Genetic Causes of Human NK Cell Deficiency and Their Effect on NK Cell Subsets. Frontiers in Immunology. 7: 545. PMID 27994588 DOI: 10.3389/fimmu.2016.00545  0.32
2016 Hsu HT, Mace EM, Carisey AF, Viswanath DI, Christakou AE, Wiklund M, Önfelt B, Orange JS. NK cells converge lytic granules to promote cytotoxicity and prevent bystander killing. The Journal of Cell Biology. PMID 27903610 DOI: 10.1083/jcb.201604136  0.32
2016 Mace EM, Bigley V, Gunesch JT, Chinn IK, Angelo LS, Care MA, Maisuria S, Keller MD, Togi S, Watkin LB, LaRosa DF, Jhangiani SN, Muzny DM, Stray-Pedersen A, Coban Akdemir Z, ... ... Orange JS, et al. Biallelic mutations in IRF8 impair human NK cell maturation and function. The Journal of Clinical Investigation. PMID 27893462 DOI: 10.1172/JCI86276  0.32
2016 Salzer E, Cagdas D, Hons M, Mace EM, Garncarz W, Petronczki ÖY, Platzer R, Pfajfer L, Bilic I, Ban SA, Willmann KL, Mukherjee M, Supper V, Hsu HT, Banerjee PP, ... ... Orange JS, et al. RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics. Nature Immunology. PMID 27776107 DOI: 10.1038/ni.3575  0.6
2016 Hajjar J, Hasan S, Forbes LR, Hemmige V, Orange JS. Gastric Adenocarcinoma in a Patient with X-Linked Agammaglobulinemia and HIV: Case Report and Review of the Literature. Frontiers in Pediatrics. 4: 100. PMID 27722150 DOI: 10.3389/fped.2016.00100  0.32
2016 Stray-Pedersen A, Sorte HS, Samarakoon P, Gambin T, Chinn IK, Coban Akdemir ZH, Erichsen HC, Forbes LR, Gu S, Yuan B, Jhangiani SN, Muzny DM, Rødningen OK, Sheng Y, Nicholas SK, ... ... Orange JS, et al. Primary immunodeficiency diseases: Genomic approaches delineate heterogeneous Mendelian disorders. The Journal of Allergy and Clinical Immunology. PMID 27577878 DOI: 10.1016/j.jaci.2016.05.042  0.32
2016 Yu H, Zhang VW, Stray-Pedersen A, Hanson IC, Forbes LR, de la Morena MT, Chinn IK, Gorman E, Mendelsohn NJ, Pozos T, Wiszniewski W, Nicholas SK, Yates AB, Moore LE, Berge KE, ... ... Orange JS, et al. Rapid molecular diagnostics of severe primary immunodeficiency determined by using targeted next-generation sequencing. The Journal of Allergy and Clinical Immunology. PMID 27484032 DOI: 10.1016/j.jaci.2016.05.035  0.32
2016 Kritikou JS, Dahlberg CI, Baptista MA, Wagner AK, Banerjee PP, Gwalani LA, Poli C, Panda SK, Kärre K, Kaech SM, Wermeling F, Andersson J, Orange JS, Brauner H, Westerberg LS. IL-2 in the tumor microenvironment is necessary for Wiskott-Aldrich syndrome protein deficient NK cells to respond to tumors in vivo. Scientific Reports. 6: 30636. PMID 27477778 DOI: 10.1038/srep30636  0.6
2016 Mace EM, Gunesch JT, Dixon A, Orange JS. Human NK cell development requires CD56-mediated motility and formation of the developmental synapse. Nature Communications. 7: 12171. PMID 27435370 DOI: 10.1038/ncomms12171  0.32
2016 van der Crabben SN, Hennus MP, McGregor GA, Ritter DI, Nagamani SC, Wells OS, Harakalova M, Chinn IK, Alt A, Vondrova L, Hochstenbach R, van Montfrans JM, Terheggen-Lagro SW, van Lieshout S, van Roosmalen MJ, ... ... Orange JS, et al. Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease. The Journal of Clinical Investigation. PMID 27427983 DOI: 10.1172/JCI82890  0.96
2016 Hegde M, Mukherjee M, Grada Z, Pignata A, Landi D, Navai SA, Wakefield A, Fousek K, Bielamowicz K, Chow KK, Brawley VS, Byrd TT, Krebs S, Gottschalk S, Wels WS, ... ... Orange JS, et al. Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape. The Journal of Clinical Investigation. PMID 27427982 DOI: 10.1172/JCI83416  0.96
2016 DiNardo AR, Mace EM, Lesteberg K, Cirillo JD, Mandalakas AM, Graviss EA, Orange JS, Makedonas G. Schistosome Soluble Egg Antigen Decreases Mycobacterium tuberculosis-Specific CD4+ T-Cell Effector Function With Concomitant Arrest of Macrophage Phago-Lysosome Maturation. The Journal of Infectious Diseases. 214: 479-88. PMID 27389351 DOI: 10.1093/infdis/jiw156  0.32
2016 DiNardo CD, Bannon SA, Routbort M, Franklin A, Mork M, Armanios M, Mace EM, Orange JS, Jeff-Eke M, Churpek JE, Takahashi K, Jorgensen JL, Garcia-Manero G, Kornblau S, Bertuch A, et al. Evaluation of Patients and Families With Concern for Predispositions to Hematologic Malignancies Within the Hereditary Hematologic Malignancy Clinic (HHMC). Clinical Lymphoma, Myeloma & Leukemia. PMID 27210295 DOI: 10.1016/j.clml.2016.04.001  0.96
2016 Mace EM, Orange JS. High- and Super-Resolution Microscopy Imaging of the NK Cell Immunological Synapse. Methods in Molecular Biology (Clifton, N.J.). 1441: 141-50. PMID 27177663 DOI: 10.1007/978-1-4939-3684-7_12  0.32
2016 Burns AM, Kushner JA, Ward MA, Turner TL, Kline MW, Orange JS. Strengthening the Pipeline for Clinician-Scientists: The Pediatrician-Scientist Training and Development Program at Texas Children's Hospital. The Journal of Pediatrics. 172: 5-6.e5. PMID 27112081 DOI: 10.1016/j.jpeds.2016.02.002  0.96
2016 Vece TJ, Watkin LB, Nicholas SK, Canter D, Braun MC, Guillerman RP, Eldin KW, Bertolet G, McKinley SD, de Guzman M, Forbes LR, Chinn I, Orange JS. Copa Syndrome: a Novel Autosomal Dominant Immune Dysregulatory Disease. Journal of Clinical Immunology. PMID 27048656 DOI: 10.1007/s10875-016-0271-8  0.96
2016 Netter P, Chan SK, Banerjee PP, Monaco-Shawver L, Noroski LM, Hanson IC, Forbes LR, Mace EM, Chinen J, Gaspar HB, Sleiman P, Hakonarson H, Klein C, Ehlayel MS, Orange JS. A novel Rab27a mutation binds melanophilin, but not Munc13-4, causing immunodeficiency without albinism. The Journal of Allergy and Clinical Immunology. PMID 27016801 DOI: 10.1016/j.jaci.2015.12.1337  0.96
2016 Keller MD, Pandey R, Li D, Glessner J, Tian L, Henrickson SE, Chinn IK, Monaco-Shawver L, Heimall J, Hou C, Otieno FG, Jyonouchi S, Calabrese L, van Montfrans J, Orange JS, et al. Mutation in IRF2BP2 is responsible for a familial form of common variable immunodeficiency disorder. The Journal of Allergy and Clinical Immunology. PMID 27016798 DOI: 10.1016/j.jaci.2016.01.018  0.96
2016 DiNardo AR, Mandalakas AM, Maphalala G, Mtetwa G, Mndzebele T, Ustero P, Hlatshwayo M, Mace EM, Orange JS, Makedonas G. HIV Progression Perturbs the Balance of the Cell-Mediated and Anti-Inflammatory Adaptive and Innate Mycobacterial Immune Response. Mediators of Inflammation. 2016: 1478340. PMID 27006526 DOI: 10.1155/2016/1478340  0.96
2016 Kuehn HS, Boisson B, Cunningham-Rundles C, Reichenbach J, Stray-Pedersen A, Gelfand EW, Maffucci P, Pierce KR, Abbott JK, Voelkerding KV, South ST, Augustine NH, Bush JS, Dolen WK, Wray BB, ... ... Orange JS, et al. Loss of B Cells in Patients with Heterozygous Mutations in IKAROS. The New England Journal of Medicine. 374: 1032-1043. PMID 26981933 DOI: 10.1056/NEJMoa1512234  0.96
2016 Viswanath DI, Mace EM, Hsu HT, Orange JS. Quantification of natural killer cell polarization and visualization of synaptic granule externalization by imaging flow cytometry. Clinical Immunology (Orlando, Fla.). PMID 26948929 DOI: 10.1016/j.clim.2016.03.004  0.96
2016 Naik S, Nicholas SK, Martinez CA, Leen AM, Hanley PJ, Gottschalk SM, Rooney CM, Hanson IC, Krance RA, Shpall EJ, Cruz CR, Amrolia P, Lucchini G, Bunin N, Heimall J, ... ... Orange JS, et al. Adoptive immunotherapy for primary immunodeficiency disorders with virus-specific T lymphocytes. The Journal of Allergy and Clinical Immunology. PMID 26920464 DOI: 10.1016/j.jaci.2015.12.1311  0.96
2016 Lalani SR, Liu P, Rosenfeld JA, Watkin LB, Chiang T, Leduc MS, Zhu W, Ding Y, Pan S, Vetrini F, Miyake CY, Shinawi M, Gambin T, Eldomery MK, Akdemir ZH, ... ... Orange JS, et al. Recurrent Muscle Weakness with Rhabdomyolysis, Metabolic Crises, and Cardiac Arrhythmia due to Bi-allelic TANGO2 Mutations. American Journal of Human Genetics. PMID 26805781 DOI: 10.1016/j.ajhg.2015.12.008  0.96
2016 Zilberman-Rudenko J, Shawver LM, Wessel AW, Luo Y, Pelletier M, Tsai WL, Lee Y, Vonortas S, Cheng L, Ashwell JD, Orange JS, Siegel RM, Hanson EP. Recruitment of A20 by the C-terminal domain of NEMO suppresses NF-κB activation and autoinflammatory disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 26802121 DOI: 10.1073/pnas.1518163113  0.96
2016 Wu S, Orange JS, Chiou EH, Nicholas SK, Seeborg F, Gwalani LA, Kearney D, Rider NL, Rasalingam S, Hanson IC. Use of enteral immunoglobulin in NEMO syndrome for eradication of persistent symptomatic norovirus enteritis. The Journal of Allergy and Clinical Immunology. in Practice. PMID 26795245 DOI: 10.1016/j.jaip.2015.11.032  0.96
2015 Seeborg FO, Seay R, Boyle M, Boyle J, Scalchunes C, Orange JS. Perceived Health in Patients with Primary Immune Deficiency. Journal of Clinical Immunology. 35: 638-50. PMID 26453585 DOI: 10.1007/s10875-015-0196-7  0.96
2015 Spinner MA, Ker JP, Stoudenmire CJ, Fadare O, Mace EM, Orange JS, Hsu AP, Holland SM. GATA2 deficiency underlying severe blastomycosis and fatal herpes simplex virus-associated hemophagocytic lymphohistiocytosis. The Journal of Allergy and Clinical Immunology. PMID 26395816 DOI: 10.1016/j.jaci.2015.07.043  0.96
2015 Orange JS, Du W, Falsey AR. Therapeutic Immunoglobulin Selected for High Antibody Titer to RSV also Contains High Antibody Titers to Other Respiratory Viruses. Frontiers in Immunology. 6: 431. PMID 26379667 DOI: 10.3389/fimmu.2015.00431  0.96
2015 Bonilla FA, Khan DA, Ballas ZK, Chinen J, Frank MM, Hsu JT, Keller M, Kobrynski LJ, Komarow HD, Mazer B, Nelson RP, Orange JS, Routes JM, Shearer WT, Sorensen RU, ... ... Orange JS, et al. Practice parameter for the diagnosis and management of primary immunodeficiency. The Journal of Allergy and Clinical Immunology. 136: 1186-1205.e78. PMID 26371839 DOI: 10.1016/j.jaci.2015.04.049  0.96
2015 Yel L, Rabbat CJ, Cunningham-Rundles C, Orange JS, Torgerson TR, Verbsky JW, Wang Y, Fu M, Robins TS, Edwards MS, Nymann-Andersen J. A Novel Targeted Screening Tool for Hypogammaglobulinemia: Measurement of Serum Immunoglobulin (IgG, IgM, IgA) Levels from Dried Blood Spots (Ig-DBS Assay). Journal of Clinical Immunology. PMID 26275445 DOI: 10.1007/s10875-015-0184-y  0.96
2015 Hernandez-Trujillo H, Orange JS, Roy JA, Wang Y, Newcomb CN, Liu Q, Hennessy S, Lo Re V. Validity of Primary Immunodeficiency Disease Diagnoses in United States Medicaid Data. Journal of Clinical Immunology. PMID 26271389 DOI: 10.1007/s10875-015-0185-x  0.96
2015 Roybal KT, Mace EM, Clark DJ, Leard AD, Herman A, Verkade P, Orange JS, Wülfing C. Modest Interference with Actin Dynamics in Primary T Cell Activation by Antigen Presenting Cells Preferentially Affects Lamellal Signaling. Plos One. 10: e0133231. PMID 26237588 DOI: 10.1371/journal.pone.0133231  0.96
2015 Roybal KT, Mace EM, Mantell JM, Verkade P, Orange JS, Wülfing C. Early Signaling in Primary T Cells Activated by Antigen Presenting Cells Is Associated with a Deep and Transient Lamellal Actin Network. Plos One. 10: e0133299. PMID 26237050 DOI: 10.1371/journal.pone.0133299  0.96
2015 Mace EM, Orange JS. Insights into primary immune deficiency from quantitative microscopy. The Journal of Allergy and Clinical Immunology. PMID 26078103 DOI: 10.1016/j.jaci.2015.03.049  0.96
2015 Angelo LS, Banerjee PP, Monaco-Shawver L, Rosen JB, Makedonas G, Forbes LR, Mace EM, Orange JS. Practical NK cell phenotyping and variability in healthy adults. Immunologic Research. 62: 341-56. PMID 26013798 DOI: 10.1007/s12026-015-8664-y  0.96
2015 Watkin LB, Jessen B, Wiszniewski W, Vece TJ, Jan M, Sha Y, Thamsen M, Santos-Cortez RL, Lee K, Gambin T, Forbes LR, Law CS, Stray-Pedersen A, Cheng MH, Mace EM, ... ... Orange JS, et al. COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis. Nature Genetics. 47: 654-60. PMID 25894502 DOI: 10.1038/ng.3279  0.96
2015 Li J, Jørgensen SF, Maggadottir SM, Bakay M, Warnatz K, Glessner J, Pandey R, Salzer U, Schmidt RE, Perez E, Resnick E, Goldacker S, Buchta M, Witte T, Padyukov L, ... ... Orange JS, et al. Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells. Nature Communications. 6: 6804. PMID 25891430 DOI: 10.1038/ncomms7804  0.96
2015 Hernandez-Trujillo VP, Scalchunes C, Hernandez-Trujillo HS, Boyle J, Williams P, Boyle M, Orange JS. Primary Immunodeficiency Diseases: An Opportunity in Pediatrics for Improving Patient Outcomes. Clinical Pediatrics. PMID 25780256 DOI: 10.1177/0009922815574079  0.96
2015 Zheng P, Noroski LM, Hanson IC, Chen Y, Lee ME, Huang Y, Zhu MX, Banerjee PP, Makedonas G, Orange JS, Shearer WT, Liu D. Molecular mechanisms of functional natural killer deficiency in patients with partial DiGeorge syndrome. The Journal of Allergy and Clinical Immunology. 135: 1293-302. PMID 25748067 DOI: 10.1016/j.jaci.2015.01.011  0.96
2015 Maggadottir SM, Li J, Glessner JT, Li YR, Wei Z, Chang X, Mentch FD, Thomas KA, Kim CE, Zhao Y, Hou C, Wang F, Jørgensen SF, Perez EE, Sullivan KE, ... Orange JS, et al. Rare variants at 16p11.2 are associated with common variable immunodeficiency. The Journal of Allergy and Clinical Immunology. 135: 1569-77. PMID 25678086 DOI: 10.1016/j.jaci.2014.12.1939  0.96
2015 Aydin SE, Kilic SS, Aytekin C, Kumar A, Porras O, Kainulainen L, Kostyuchenko L, Genel F, Kütükcüler N, Karaca N, Gonzalez-Granado L, Abbott J, Al-Zahrani D, Rezaei N, Baz Z, ... ... Orange JS, et al. DOCK8 deficiency: clinical and immunological phenotype and treatment options - a review of 136 patients. Journal of Clinical Immunology. 35: 189-98. PMID 25627830 DOI: 10.1007/s10875-014-0126-0  0.96
2015 Briercheck EL, Trotta R, Chen L, Hartlage AS, Cole JP, Cole TD, Mao C, Banerjee PP, Hsu HT, Mace EM, Ciarlariello D, Mundy-Bosse BL, Garcia-Cao I, Scoville SD, Yu L, ... ... Orange JS, et al. PTEN is a negative regulator of NK cell cytolytic function. Journal of Immunology (Baltimore, Md. : 1950). 194: 1832-40. PMID 25595786 DOI: 10.4049/jimmunol.1401224  0.96
2015 Tuano KS, Orange JS, Sullivan K, Cunningham-Rundles C, Bonilla FA, Davis CM. Food allergy in patients with primary immunodeficiency diseases: prevalence within the US Immunodeficiency Network (USIDNET). The Journal of Allergy and Clinical Immunology. 135: 273-5. PMID 25441296 DOI: 10.1016/j.jaci.2014.09.024  0.96
2015 Jolles S, Orange JS, Gardulf A, Stein MR, Shapiro R, Borte M, Berger M. Current treatment options with immunoglobulin G for the individualization of care in patients with primary immunodeficiency disease. Clinical and Experimental Immunology. 179: 146-60. PMID 25384609 DOI: 10.1111/cei.12485  0.96
2014 Jolles S, Jordan SC, Orange JS, van Schaik IN. 7th International Immunoglobulin Conference: Foreword. Clinical and Experimental Immunology. 178: 1-2. PMID 25695109 DOI: 10.1111/cei.12489  0.96
2014 Jolles S, Jordan SC, Orange JS, van Schaik IN. Immunoglobulins: current understanding and future directions. Clinical and Experimental Immunology. 178: 163-8. PMID 25546806 DOI: 10.1111/cei.12555  0.96
2014 Orange JS. Considering the demand for and prioritization of intravenous immunoglobulin Clinical and Experimental Immunology. 178: 78-82. PMID 25546771 DOI: 10.1111/cei.12520  0.96
2014 Willmann KL, Klaver S, Do?u F, Santos-Valente E, Garncarz W, Bilic I, Mace E, Salzer E, Conde CD, Sic H, Májek P, Banerjee PP, Vladimer GI, Haskolo?lu S, Bolkent MG, ... ... Orange JS, et al. Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity. Nature Communications. 5: 5360. PMID 25406581 DOI: 10.1038/ncomms6360  0.96
2014 Hsu HT, Orange JS. Distinct integrin-dependent signals define requirements for lytic granule convergence and polarization in natural killer cells. Science Signaling. 7: pe24. PMID 25292212 DOI: 10.1126/scisignal.2005816  0.96
2014 Kamili QU, Seeborg FO, Saxena K, Nicholas SK, Banerjee PP, Angelo LS, Mace EM, Forbes LR, Martinez C, Wright TS, Orange JS, Hanson IC. Severe cutaneous human papillomavirus infection associated with natural killer cell deficiency following stem cell transplantation for severe combined immunodeficiency. The Journal of Allergy and Clinical Immunology. 134: 1451-1453.e1. PMID 25159470 DOI: 10.1016/j.jaci.2014.07.009  0.96
2014 Kwan A, Abraham RS, Currier R, Brower A, Andruszewski K, Abbott JK, Baker M, Ballow M, Bartoshesky LE, Bonilla FA, Brokopp C, Brooks E, Caggana M, Celestin J, Church JA, ... ... Orange JS, et al. Newborn screening for severe combined immunodeficiency in 11 screening programs in the United States. Jama. 312: 729-38. PMID 25138334 DOI: 10.1001/jama.2014.9132  0.96
2014 Stray-Pedersen A, Jouanguy E, Crequer A, Bertuch AA, Brown BS, Jhangiani SN, Muzny DM, Gambin T, Sorte H, Sasa G, Metry D, Campbell J, Sockrider MM, Dishop MK, Scollard DM, ... ... Orange JS, et al. Compound heterozygous CORO1A mutations in siblings with a mucocutaneous-immunodeficiency syndrome of epidermodysplasia verruciformis-HPV, molluscum contagiosum and granulomatous tuberculoid leprosy. Journal of Clinical Immunology. 34: 871-90. PMID 25073507 DOI: 10.1007/s10875-014-0074-8  0.96
2014 Garcia MN, Hause AM, Walker CM, Orange JS, Hasbun R, Murray KO. Evaluation of prolonged fatigue post-West Nile virus infection and association of fatigue with elevated antiviral and proinflammatory cytokines. Viral Immunology. 27: 327-33. PMID 25062274 DOI: 10.1089/vim.2014.0035  0.96
2014 Bayer DK, Martinez CA, Sorte HS, Forbes LR, Demmler-Harrison GJ, Hanson IC, Pearson NM, Noroski LM, Zaki SR, Bellini WJ, Leduc MS, Yang Y, Eng CM, Patel A, Rodningen OK, ... ... Orange JS, et al. Vaccine-associated varicella and rubella infections in severe combined immunodeficiency with isolated CD4 lymphocytopenia and mutations in IL7R detected by tandem whole exome sequencing and chromosomal microarray. Clinical and Experimental Immunology. 178: 459-69. PMID 25046553 DOI: 10.1111/cei.12421  0.96
2014 Hedayat M, Massaad MJ, Lee YN, Conley ME, Orange JS, Ohsumi TK, Al-Herz W, Notarangelo LD, Geha RS, Chou J. Lessons in gene hunting: a RAG1 mutation presenting with agammaglobulinemia and absence of B cells. The Journal of Allergy and Clinical Immunology. 134: 983-5.e1. PMID 24985406 DOI: 10.1016/j.jaci.2014.04.037  0.96
2014 Stray-Pedersen A, Backe PH, Sorte HS, Mørkrid L, Chokshi NY, Erichsen HC, Gambin T, Elgstøen KB, Bjørås M, Wlodarski MW, Krüger M, Jhangiani SN, Muzny DM, Patel A, Raymond KM, ... ... Orange JS, et al. PGM3 mutations cause a congenital disorder of glycosylation with severe immunodeficiency and skeletal dysplasia. American Journal of Human Genetics. 95: 96-107. PMID 24931394 DOI: 10.1016/j.ajhg.2014.05.007  0.96
2014 Zhu S, Phatarpekar PV, Denman CJ, Senyukov VV, Somanchi SS, Nguyen-Jackson HT, Mace EM, Freeman AF, Watowich SS, Orange JS, Holland SM, Lee DA. Transcription of the activating receptor NKG2D in natural killer cells is regulated by STAT3 tyrosine phosphorylation. Blood. 124: 403-11. PMID 24891320 DOI: 10.1182/blood-2013-05-499707  0.96
2014 Mace EM, Orange JS. Lytic immune synapse function requires filamentous actin deconstruction by Coronin 1A. Proceedings of the National Academy of Sciences of the United States of America. 111: 6708-13. PMID 24760828 DOI: 10.1073/pnas.1314975111  0.96
2014 Mace EM, Orange JS. Visualization of the immunological synapse by dual color time-gated stimulated emission depletion (STED) nanoscopy. Journal of Visualized Experiments : Jove. PMID 24686478 DOI: 10.3791/51100  0.96
2014 Shearer WT, Fleisher TA, Buckley RH, Ballas Z, Ballow M, Blaese RM, Bonilla FA, Conley ME, Cunningham-Rundles C, Filipovich AH, Fuleihan R, Gelfand EW, Hernandez-Trujillo V, Holland SM, ... ... Orange JS, et al. Recommendations for live viral and bacterial vaccines in immunodeficient patients and their close contacts. The Journal of Allergy and Clinical Immunology. 133: 961-6. PMID 24582311 DOI: 10.1016/j.jaci.2013.11.043  0.96
2014 Bassiri H, Das R, Guan P, Barrett DM, Brennan PJ, Banerjee PP, Wiener SJ, Orange JS, Brenner MB, Grupp SA, Nichols KE. iNKT cell cytotoxic responses control T-lymphoma growth in vitro and in vivo . Cancer Immunology Research. 2: 59-69. PMID 24563871 DOI: 10.1158/2326-6066.CIR-13-0104  0.96
2014 Gray CM, Remouchamps C, McCorkell KA, Solt LA, Dejardin E, Orange JS, May MJ. Noncanonical NF-κB signaling is limited by classical NF-κB activity. Science Signaling. 7: ra13. PMID 24497610 DOI: 10.1126/scisignal.2004557  0.96
2014 Mace EM, Dongre P, Hsu HT, Sinha P, James AM, Mann SS, Forbes LR, Watkin LB, Orange JS. Cell biological steps and checkpoints in accessing NK cell cytotoxicity. Immunology and Cell Biology. 92: 245-55. PMID 24445602 DOI: 10.1038/icb.2013.96  0.96
2014 Stonebraker JS, Farrugia A, Gathmann B, Orange JS. Modeling primary immunodeficiency disease epidemiology and its treatment to estimate latent therapeutic demand for immunoglobulin. Journal of Clinical Immunology. 34: 233-44. PMID 24338563 DOI: 10.1007/s10875-013-9975-1  0.96
2014 Keller M, Glessner J, Resnick E, Perez E, Chapel H, Lucas M, Sullivan KE, Cunningham-Rundles C, Orange JS, Hakonarson H. Burden of copy number variation in common variable immunodeficiency. Clinical and Experimental Immunology. 177: 269-71. PMID 24329717 DOI: 10.1111/cei.12255  0.96
2014 Spinner MA, Sanchez LA, Hsu AP, Shaw PA, Zerbe CS, Calvo KR, Arthur DC, Gu W, Gould CM, Brewer CC, Cowen EW, Freeman AF, Olivier KN, Uzel G, Zelazny AM, ... ... Orange JS, et al. GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics, and immunity. Blood. 123: 809-21. PMID 24227816 DOI: 10.1182/blood-2013-07-515528  0.96
2014 Chapel H, Prevot J, Gaspar HB, Español T, Bonilla FA, Solis L, Drabwell J, Ballow M, Brown L, Costa-Carvalho BT, Edgar JD, Egner W, Ehl S, Esser M, Gardulf A, ... ... Orange JS, et al. Primary immune deficiencies - principles of care Frontiers in Immunology. 5. DOI: 10.3389/fimmu.2014.00627  0.96
2013 Tuli A, Thiery J, James AM, Michelet X, Sharma M, Garg S, Sanborn KB, Orange JS, Lieberman J, Brenner MB. Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity. Molecular Biology of the Cell. 24: 3721-35. PMID 24088571 DOI: 10.1091/mbc.E13-05-0259  0.96
2013 Orange JS. Natural killer cell deficiency. The Journal of Allergy and Clinical Immunology. 132: 515-25; quiz 526. PMID 23993353 DOI: 10.1016/j.jaci.2013.07.020  0.96
2013 Aiuti A, Biasco L, Scaramuzza S, Ferrua F, Cicalese MP, Baricordi C, Dionisio F, Calabria A, Giannelli S, Castiello MC, Bosticardo M, Evangelio C, Assanelli A, Casiraghi M, Di Nunzio S, ... ... Orange JS, et al. Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome. Science (New York, N.Y.). 341: 1233151. PMID 23845947 DOI: 10.1126/science.1233151  0.96
2013 Orange JS, Ochs HD, Cunningham-Rundles C. Prioritization of evidence-based indications for intravenous immunoglobulin. Journal of Clinical Immunology. 33: 1033-6. PMID 23764872 DOI: 10.1007/s10875-013-9912-3  0.96
2013 Hu A, Josephson MB, Diener BL, Nino G, Xu S, Paranjape C, Orange JS, Grunstein MM. Pro-asthmatic cytokines regulate unliganded and ligand-dependent glucocorticoid receptor signaling in airway smooth muscle. Plos One. 8: e60452. PMID 23593222 DOI: 10.1371/journal.pone.0060452  0.96
2013 Berger M, Jolles S, Orange JS, Sleasman JW. Bioavailability of IgG administered by the subcutaneous route. Journal of Clinical Immunology. 33: 984-90. PMID 23456255 DOI: 10.1007/s10875-013-9876-3  0.96
2013 McLane LM, Banerjee PP, Cosma GL, Makedonas G, Wherry EJ, Orange JS, Betts MR. Differential localization of T-bet and Eomes in CD8 T cell memory populations Journal of Immunology. 190: 3207-3215. PMID 23455505 DOI: 10.4049/jimmunol.1201556  0.96
2013 Das R, Bassiri H, Guan P, Wiener S, Banerjee PP, Zhong MC, Veillette A, Orange JS, Nichols KE. The adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation. Blood. 121: 3386-95. PMID 23430111 DOI: 10.1182/blood-2012-11-468868  0.96
2013 May RM, Okumura M, Hsu CJ, Bassiri H, Yang E, Rak G, Mace EM, Philip NH, Zhang W, Baumgart T, Orange JS, Nichols KE, Kambayashi T. Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function. Blood. 121: 3135-46. PMID 23407547 DOI: 10.1182/blood-2012-12-474361  0.96
2013 James AM, Hsu HT, Dongre P, Uzel G, Mace EM, Banerjee PP, Orange JS. Rapid activation receptor- or IL-2-induced lytic granule convergence in human natural killer cells requires Src, but not downstream signaling. Blood. 121: 2627-37. PMID 23380740 DOI: 10.1182/blood-2012-06-437012  0.96
2013 Mizesko MC, Banerjee PP, Monaco-Shawver L, Mace EM, Bernal WE, Sawalle-Belohradsky J, Belohradsky BH, Heinz V, Freeman AF, Sullivan KE, Holland SM, Torgerson TR, Al-Herz W, Chou J, Hanson IC, ... ... Orange JS, et al. Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency. The Journal of Allergy and Clinical Immunology. 131: 840-8. PMID 23380217 DOI: 10.1016/j.jaci.2012.12.1568  0.96
2013 Mace EM, Hsu AP, Monaco-Shawver L, Makedonas G, Rosen JB, Dropulic L, Cohen JI, Frenkel EP, Bagwell JC, Sullivan JL, Biron CA, Spalding C, Zerbe CS, Uzel G, Holland SM, ... Orange JS, et al. Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56(bright) subset. Blood. 121: 2669-77. PMID 23365458 DOI: 10.1182/blood-2012-09-453969  0.96
2013 Keller MD, Sadeghin T, Samango-Sprouse C, Orange JS. Immunodeficiency in patients with 49,XXXXY chromosomal variation. American Journal of Medical Genetics. Part C, Seminars in Medical Genetics. 163: 50-4. PMID 23345259 DOI: 10.1002/ajmg.c.31348  0.96
2013 Keller MD, Ganesh J, Heltzer M, Paessler M, Bergqvist AG, Baluarte HJ, Watkins D, Rosenblatt DS, Orange JS. Severe combined immunodeficiency resulting from mutations in MTHFD1. Pediatrics. 131: e629-34. PMID 23296427 DOI: 10.1542/peds.2012-0899  0.96
2013 Orange JS, Katial R. Reply: To PMID 22935624. The Journal of Allergy and Clinical Immunology. 131: 617-8. PMID 23273954 DOI: 10.1016/j.jaci.2012.11.030  0.96
2012 Mace EM, Orange JS. New views of the human NK cell immunological synapse: recent advances enabled by super- and high-resolution imaging techniques. Frontiers in Immunology. 3: 421. PMID 23316204 DOI: 10.3389/fimmu.2012.00421  0.96
2012 Comerci CJ, Mace EM, Banerjee PP, Orange JS. CD2 promotes human natural killer cell membrane nanotube formation. Plos One. 7: e47664. PMID 23112830 DOI: 10.1371/journal.pone.0047664  0.96
2012 Mace EM, Wu WW, Ho T, Mann SS, Hsu HT, Orange JS. NK cell lytic granules are highly motile at the immunological synapse and require F-actin for post-degranulation persistence. Journal of Immunology (Baltimore, Md. : 1950). 189: 4870-80. PMID 23066148 DOI: 10.4049/jimmunol.1201296  0.96
2012 Grier JT, Forbes LR, Monaco-Shawver L, Oshinsky J, Atkinson TP, Moody C, Pandey R, Campbell KS, Orange JS. Human immunodeficiency-causing mutation defines CD16 in spontaneous NK cell cytotoxicity Journal of Clinical Investigation. 122: 3769-3780. PMID 23006327 DOI: 10.1172/JCI64837  0.96
2012 Orange JS, Ballow M, Stiehm ER, Ballas ZK, Chinen J, De La Morena M, Kumararatne D, Harville TO, Hesterberg P, Koleilat M, McGhee S, Perez EE, Raasch J, Scherzer R, Schroeder H, et al. Use and interpretation of diagnostic vaccination in primary immunodeficiency: a working group report of the Basic and Clinical Immunology Interest Section of the American Academy of Allergy, Asthma & Immunology. The Journal of Allergy and Clinical Immunology. 130: S1-24. PMID 22935624 DOI: 10.1016/j.jaci.2012.07.002  0.96
2012 Mace EM, Orange JS. Dual channel STED nanoscopy of lytic granules on actin filaments in natural killer cells. Communicative & Integrative Biology. 5: 184-6. PMID 22808328 DOI: 10.4161/cib.18818  0.32
2012 Orange JS, Belohradsky BH, Berger M, Borte M, Hagan J, Jolles S, Wasserman RL, Baggish JS, Saunders R, Grimbacher B. Evaluation of correlation between dose and clinical outcomes in subcutaneous immunoglobulin replacement therapy Clinical and Experimental Immunology. 169: 172-181. PMID 22774992 DOI: 10.1111/j.1365-2249.2012.04594.x  0.96
2012 Hernandez-Trujillo HS, Chapel H, Lo Re V, Notarangelo LD, Gathmann B, Grimbacher B, Boyle JM, Hernandez-Trujillo VP, Scalchunes C, Boyle ML, Orange JS. Comparison of American and European practices in the management of patients with primary immunodeficiencies. Clinical and Experimental Immunology. 169: 57-69. PMID 22670779 DOI: 10.1111/j.1365-2249.2012.04588.x  0.96
2012 Garrett JP, Fung I, Rupon J, Knight A, Mizesko M, Paessler M, Orange JS. Presentation of hemophagocytic lymphohistiocytosis due to a novel MUNC 13-4 mutation masked by partial therapeutic immunosuppression. Pediatric Rheumatology Online Journal. 10: 13. PMID 22554126 DOI: 10.1186/1546-0096-10-13  0.96
2012 Hill DA, Siracusa MC, Abt MC, Kim BS, Kobuley D, Kubo M, Kambayashi T, Larosa DF, Renner ED, Orange JS, Bushman FD, Artis D. Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation. Nature Medicine. 18: 538-46. PMID 22447074 DOI: 10.1038/nm.2657  0.96
2012 Heyward CY, Patel R, Mace EM, Grier JT, Guan H, Makrigiannis AP, Orange JS, Ricciardi RP. Tumorigenic adenovirus 12 cells evade NK cell lysis by reducing the expression of NKG2D ligands. Immunology Letters. 144: 16-23. PMID 22445355 DOI: 10.1016/j.imlet.2012.03.001  0.96
2012 Shaw RK, Issekutz AC, Fraser R, Schmit P, Morash B, Monaco-Shawver L, Orange JS, Fernandez CV. Bilateral adrenal EBV-associated smooth muscle tumors in a child with a natural killer cell deficiency. Blood. 119: 4009-12. PMID 22427204 DOI: 10.1182/blood-2011-10-385377  0.96
2012 Orange JS. Unraveling human natural killer cell deficiency. The Journal of Clinical Investigation. 122: 798-801. PMID 22354165 DOI: 10.1172/JCI62620  0.96
2012 Saltzman RW, Monaco-Shawver L, Zhang K, Sullivan KE, Filipovich AH, Orange JS. Novel mutation in STXBP2 prevents IL-2-induced natural killer cell cytotoxicity. The Journal of Allergy and Clinical Immunology. 129: 1666-8. PMID 22336081 DOI: 10.1016/j.jaci.2011.12.1003  0.96
2012 Carpenter EL, Haglund EA, Mace EM, Deng D, Martinez D, Wood AC, Chow AK, Weiser DA, Belcastro LT, Winter C, Bresler SC, Vigny M, Mazot P, Asgharzadeh S, Seeger RC, ... ... Orange JS, et al. Antibody targeting of anaplastic lymphoma kinase induces cytotoxicity of human neuroblastoma. Oncogene. 31: 4859-67. PMID 22266870 DOI: 10.1038/onc.2011.647  0.96
2012 van Montfrans JM, Hoepelman AI, Otto S, van Gijn M, van de Corput L, de Weger RA, Monaco-Shawver L, Banerjee PP, Sanders EA, Jol-van der Zijde CM, Betts MR, Orange JS, Bloem AC, Tesselaar K. CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia. The Journal of Allergy and Clinical Immunology. 129: 787-793.e6. PMID 22197273 DOI: 10.1016/j.jaci.2011.11.013  0.96
2012 Pedroza LA, Kumar V, Sanborn KB, Mace EM, Niinikoski H, Nadeau K, Vasconcelos Dde M, Perez E, Jyonouchi S, Jyonouchi H, Banerjee PP, Ruuskanen O, Condino-Neto A, Orange JS. Autoimmune regulator (AIRE) contributes to Dectin-1-induced TNF-α production and complexes with caspase recruitment domain-containing protein 9 (CARD9), spleen tyrosine kinase (Syk), and Dectin-1. The Journal of Allergy and Clinical Immunology. 129: 464-72, 472.e1-3. PMID 21962774 DOI: 10.1016/j.jaci.2011.08.027  0.96
2011 Keller MD, Petersen M, Ong P, Church J, Risma K, Burham J, Jain A, Stiehm ER, Hanson EP, Uzel G, Deardorff MA, Orange JS. Hypohidrotic ectodermal dysplasia and immunodeficiency with coincident NEMO and EDA mutations. Frontiers in Immunology. 2: 61. PMID 22566850 DOI: 10.3389/fimmu.2011.00061  0.96
2011 Mace EM, Orange JS. Multiple distinct NK-cell synapses. Blood. 118: 6475-6. PMID 22174302 DOI: 10.1182/blood-2011-10-381392  0.96
2011 Sanborn KB, Mace EM, Rak GD, Difeo A, Martignetti JA, Pecci A, Bussel JB, Favier R, Orange JS. Phosphorylation of the myosin IIA tailpiece regulates single myosin IIA molecule association with lytic granules to promote NK-cell cytotoxicity. Blood. 118: 5862-71. PMID 22123909 DOI: 10.1182/blood-2011-03-344846  0.96
2011 Modell V, Gee B, Lewis DB, Orange JS, Roifman CM, Routes JM, Sorensen RU, Notarangelo LD, Modell F. Global study of primary immunodeficiency diseases (PI)--diagnosis, treatment, and economic impact: an updated report from the Jeffrey Modell Foundation. Immunologic Research. 51: 61-70. PMID 21935653 DOI: 10.1007/s12026-011-8241-y  0.96
2011 Rak GD, Mace EM, Banerjee PP, Svitkina T, Orange JS. Natural killer cell lytic granule secretion occurs through a pervasive actin network at the immune synapse. Plos Biology. 9: e1001151. PMID 21931536 DOI: 10.1371/journal.pbio.1001151  0.96
2011 Watkins D, Schwartzentruber JA, Ganesh J, Orange JS, Kaplan BS, Nunez LD, Majewski J, Rosenblatt DS. Novel inborn error of folate metabolism: identification by exome capture and sequencing of mutations in the MTHFD1 gene in a single proband. Journal of Medical Genetics. 48: 590-2. PMID 21813566 DOI: 10.1136/jmedgenet-2011-100286  0.96
2011 Karamchandani-Patel G, Hanson EP, Saltzman R, Kimball CE, Sorensen RU, Orange JS. Congenital alterations of NEMO glutamic acid 223 result in hypohidrotic ectodermal dysplasia and immunodeficiency with normal serum IgG levels. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology. 107: 50-6. PMID 21704885 DOI: 10.1016/j.anai.2011.03.009  0.96
2011 Hsu AP, Sampaio EP, Khan J, Calvo KR, Lemieux JE, Patel SY, Frucht DM, Vinh DC, Auth RD, Freeman AF, Olivier KN, Uzel G, Zerbe CS, Spalding C, Pittaluga S, ... ... Orange JS, et al. Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome. Blood. 118: 2653-5. PMID 21670465 DOI: 10.1182/blood-2011-05-356352  0.96
2011 Poliak N, Orange JS, Pawel BR, Weiss PF. Eosinophilic fasciitis mimicking angioedema and treatment response to infliximab in a pediatric patient. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology. 106: 444-5. PMID 21530881 DOI: 10.1016/j.anai.2011.01.021  0.96
2011 Orange JS, Glessner JT, Resnick E, Sullivan KE, Lucas M, Ferry B, Kim CE, Hou C, Wang F, Chiavacci R, Kugathasan S, Sleasman JW, Baldassano R, Perez EE, Chapel H, et al. Genome-wide association identifies diverse causes of common variable immunodeficiency. The Journal of Allergy and Clinical Immunology. 127: 1360-7.e6. PMID 21497890 DOI: 10.1016/j.jaci.2011.02.039  0.96
2011 Jyonouchi S, Abraham V, Orange JS, Spergel JM, Gober L, Dudek E, Saltzman R, Nichols KE, Cianferoni A. Invariant natural killer T cells from children with versus without food allergy exhibit differential responsiveness to milk-derived sphingomyelin. The Journal of Allergy and Clinical Immunology. 128: 102-109.e13. PMID 21458849 DOI: 10.1016/j.jaci.2011.02.026  0.96
2011 Orange JS, Roy-Ghanta S, Mace EM, Maru S, Rak GD, Sanborn KB, Fasth A, Saltzman R, Paisley A, Monaco-Shawver L, Banerjee PP, Pandey R. IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function. The Journal of Clinical Investigation. 121: 1535-48. PMID 21383498 DOI: 10.1172/JCI44862  0.96
2011 Kumar V, Pedroza LA, Mace EM, Seeholzer S, Cotsarelis G, Condino-Neto A, Payne AS, Orange JS. The autoimmune regulator (AIRE), which is defective in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy patients, is expressed in human epidermal and follicular keratinocytes and associates with the intermediate filament protein cytokeratin 17. The American Journal of Pathology. 178: 983-8. PMID 21356351 DOI: 10.1016/j.ajpath.2010.12.007  0.96
2011 Monaco-Shawver L, Schwartz L, Tuluc F, Guo CJ, Lai JP, Gunnam SM, Kilpatrick LE, Banerjee PP, Douglas SD, Orange JS. Substance P inhibits natural killer cell cytotoxicity through the neurokinin-1 receptor. Journal of Leukocyte Biology. 89: 113-25. PMID 20940324 DOI: 10.1189/jlb.0410200  0.96
2010 Boztug K, Schmidt M, Schwarzer A, Banerjee PP, Díez IA, Dewey RA, Böhm M, Nowrouzi A, Ball CR, Glimm H, Naundorf S, Kühlcke K, Blasczyk R, Kondratenko I, Maródi L, ... Orange JS, et al. Stem-cell gene therapy for the Wiskott-Aldrich syndrome. The New England Journal of Medicine. 363: 1918-27. PMID 21067383 DOI: 10.1056/NEJMoa1003548  0.96
2010 Uzel G, Orange JS, Poliak N, Marciano BE, Heller T, Holland SM. Complications of tumor necrosis factor-α blockade in chronic granulomatous disease-related colitis. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 51: 1429-34. PMID 21058909 DOI: 10.1086/657308  0.96
2010 Stiehm ER, Orange JS, Ballow M, Lehman H. Therapeutic use of immunoglobulins. Advances in Pediatrics. 57: 185-218. PMID 21056739 DOI: 10.1016/j.yapd.2010.08.005  0.96
2010 Yatherajam G, Banerjee PP, McCorkell KA, Solt LA, Hanson EP, Madge LA, Kang S, Worley PF, Orange JS, May MJ. Cutting edge: association with I kappa B kinase beta regulates the subcellular localization of Homer3. Journal of Immunology (Baltimore, Md. : 1950). 185: 2665-9. PMID 20693425 DOI: 10.4049/jimmunol.0903488  0.96
2010 Yu D, dos Santos CO, Zhao G, Jiang J, Amigo JD, Khandros E, Dore LC, Yao Y, D'Souza J, Zhang Z, Ghaffari S, Choi J, Friend S, Tong W, Orange JS, et al. miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta. Genes & Development. 24: 1620-33. PMID 20679398 DOI: 10.1101/gad.1942110  0.96
2010 Orange JS, Grossman WJ, Navickis RJ, Wilkes MM. Impact of trough IgG on pneumonia incidence in primary immunodeficiency: A meta-analysis of clinical studies. Clinical Immunology (Orlando, Fla.). 137: 21-30. PMID 20675197 DOI: 10.1016/j.clim.2010.06.012  0.96
2010 Wang HY, Gopalan V, Aksentijevich I, Yeager M, Ma CA, Mohamoud YA, Quinones M, Matthews C, Boland J, Niemela JE, Torgerson TR, Giliani S, Uzel G, Orange JS, Shapiro R, et al. A custom 148 gene-based resequencing chip and the SNP explorer software: new tools to study antibody deficiency. Human Mutation. 31: 1080-8. PMID 20652909 DOI: 10.1002/humu.21322  0.96
2010 Devora GA, Sun L, Chen Z, van Oers NS, Hanson EP, Orange JS, de la Morena MT. A novel missense mutation in the nuclear factor-κB essential modulator (NEMO) gene resulting in impaired activation of the NF-κB pathway and a unique clinical phenotype presenting as MRSA subdural empyema. Journal of Clinical Immunology. 30: 881-5. PMID 20652730 DOI: 10.1007/s10875-010-9445-y  0.96
2010 Orange JS. Latent herpesviruses: aligning human and murine NK cells. Blood. 115: 4321-2. PMID 20522715 DOI: 10.1182/blood-2010-03-271361  0.96
2010 Hagan JB, Fasano MB, Spector S, Wasserman RL, Melamed I, Rojavin MA, Zenker O, Orange JS. Efficacy and safety of a new 20% immunoglobulin preparation for subcutaneous administration, IgPro20, in patients with primary immunodeficiency. Journal of Clinical Immunology. 30: 734-45. PMID 20454851 DOI: 10.1007/s10875-010-9423-4  0.96
2010 Mentlik AN, Sanborn KB, Holzbaur EL, Orange JS. Rapid lytic granule convergence to the MTOC in natural killer cells is dependent on dynein but not cytolytic commitment. Molecular Biology of the Cell. 21: 2241-56. PMID 20444980 DOI: 10.1091/mbc.E09-11-0930  0.96
2010 Yong PL, Orange JS, Sullivan KE. Pediatric common variable immunodeficiency: immunologic and phenotypic associations with switched memory B cells. Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology. 21: 852-8. PMID 20337966 DOI: 10.1111/j.1399-3038.2010.01004.x  0.96
2010 Sanborn KB, Orange JS. Navigating barriers: the challenge of directed secretion at the natural killer cell lytic immunological synapse. Journal of Clinical Immunology. 30: 358-63. PMID 20191315 DOI: 10.1007/s10875-010-9372-y  0.96
2010 Banerjee PP, Orange JS. Quantitative measurement of F-actin accumulation at the NK cell immunological synapse. Journal of Immunological Methods. 355: 1-13. PMID 20171970 DOI: 10.1016/j.jim.2010.02.003  0.96
2010 Sanborn KB, Rak GD, Mentlik AN, Banerjee PP, Orange JS. Analysis of the NK cell immunological synapse. Methods in Molecular Biology (Clifton, N.J.). 612: 127-48. PMID 20033638 DOI: 10.1007/978-1-60761-362-6_9  0.96
2010 Yong PL, Boyle J, Ballow M, Boyle M, Berger M, Bleesing J, Bonilla FA, Chinen J, Cunninghamm-Rundles C, Fuleihan R, Nelson L, Wasserman RL, Williams KC, Orange JS. Use of intravenous immunoglobulin and adjunctive therapies in the treatment of primary immunodeficiencies: A working group report of and study by the Primary Immunodeficiency Committee of the American Academy of Allergy Asthma and Immunology. Clinical Immunology (Orlando, Fla.). 135: 255-63. PMID 19914873 DOI: 10.1016/j.clim.2009.10.003  0.96
2010 Roy-Ghanta S, Orange JS. Use of cytokine therapy in primary immunodeficiency. Clinical Reviews in Allergy & Immunology. 38: 39-53. PMID 19449141 DOI: 10.1007/s12016-009-8131-4  0.96
2009 Savic V, Sanborn KB, Orange JS, Bassing CH. Chipping away at gamma-H2AX foci. Cell Cycle (Georgetown, Tex.). 8: 3285-90. PMID 19770593  0.96
2009 Renner ED, Hartl D, Rylaarsdam S, Young ML, Monaco-Shawver L, Kleiner G, Markert ML, Stiehm ER, Belohradsky BH, Upton MP, Torgerson TR, Orange JS, Ochs HD. Comèl-Netherton syndrome defined as primary immunodeficiency. The Journal of Allergy and Clinical Immunology. 124: 536-43. PMID 19683336 DOI: 10.1016/j.jaci.2009.06.009  0.96
2009 Sanborn KB, Rak GD, Maru SY, Demers K, Difeo A, Martignetti JA, Betts MR, Favier R, Banerjee PP, Orange JS. Myosin IIA associates with NK cell lytic granules to enable their interaction with F-actin and function at the immunological synapse. Journal of Immunology (Baltimore, Md. : 1950). 182: 6969-84. PMID 19454694 DOI: 10.4049/jimmunol.0804337  0.96
2009 Pien GC, Basner-Tschakarjan E, Hui DJ, Mentlik AN, Finn JD, Hasbrouck NC, Zhou S, Murphy SL, Maus MV, Mingozzi F, Orange JS, High KA. Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors. The Journal of Clinical Investigation. 119: 1688-95. PMID 19436115 DOI: 10.1172/JCI36891  0.96
2009 Makedonas G, Banerjee PP, Pandey R, Hersperger AR, Sanborn KB, Hardy GA, Orange JS, Betts MR. Rapid up-regulation and granule-independent transport of perforin to the immunological synapse define a novel mechanism of antigen-specific CD8+ T cell cytotoxic activity. Journal of Immunology (Baltimore, Md. : 1950). 182: 5560-9. PMID 19380804 DOI: 10.4049/jimmunol.0803945  0.96
2009 Heltzer ML, Coffin SE, Maurer K, Bagashev A, Zhang Z, Orange JS, Sullivan KE. Immune dysregulation in severe influenza. Journal of Leukocyte Biology. 85: 1036-43. PMID 19276177 DOI: 10.1189/jlb.1108710  0.96
2009 Fish JD, Duerst RE, Gelfand EW, Orange JS, Bunin N. Challenges in the use of allogeneic hematopoietic SCT for ectodermal dysplasia with immune deficiency Bone Marrow Transplantation. 43: 217-221. PMID 18794870 DOI: 10.1038/bmt.2008.308  0.96
2008 Orange JS. Formation and function of the lytic NK-cell immunological synapse. Nature Reviews. Immunology. 8: 713-25. PMID 19172692 DOI: 10.1038/nri2381  0.96
2008 Pai SY, Levy O, Jabara HH, Glickman JN, Stoler-Barak L, Sachs J, Nurko S, Orange JS, Geha RS. Allogeneic transplantation successfully corrects immune defects, but not susceptibility to colitis, in a patient with nuclear factor-kappaB essential modulator deficiency. The Journal of Allergy and Clinical Immunology. 122: 1113-1118.e1. PMID 18851875 DOI: 10.1016/j.jaci.2008.08.026  0.96
2008 Hanson EP, Monaco-Shawver L, Solt LA, Madge LA, Banerjee PP, May MJ, Orange JS. Hypomorphic nuclear factor-kappaB essential modulator mutation database and reconstitution system identifies phenotypic and immunologic diversity. The Journal of Allergy and Clinical Immunology. 122: 1169-1177.e16. PMID 18851874 DOI: 10.1016/j.jaci.2008.08.018  0.96
2008 Orange JS, May MJ. Cell penetrating peptide inhibitors of Nuclear Factor-kappa B Cellular and Molecular Life Sciences. 65: 3564-3591. PMID 18668204 DOI: 10.1007/s00018-008-8222-z  0.96
2008 Perez EE, Wang J, Miller JC, Jouvenot Y, Kim KA, Liu O, Wang N, Lee G, Bartsevich VV, Lee YL, Guschin DY, Rupniewski I, Waite AJ, Carpenito C, Carroll RG, ... Orange JS, et al. Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases. Nature Biotechnology. 26: 808-16. PMID 18587387 DOI: 10.1038/nbt1410  0.96
2008 Suhoski MM, Perez EE, Heltzer ML, Laney A, Shaffer LG, Saitta S, Nachman S, Spinner NB, June CH, Orange JS. Monosomy 1p36 uncovers a role for OX40 in survival of activated CD4+ T cells. Clinical Immunology (Orlando, Fla.). 128: 181-9. PMID 18511345 DOI: 10.1016/j.clim.2008.03.522  0.96
2008 Pien GC, Orange JS. Evaluation and clinical interpretation of hypergammaglobulinemia E: differentiating atopy from immunodeficiency. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology. 100: 392-5. PMID 18450128 DOI: 10.1016/S1081-1206(10)60605-9  0.96
2008 Orange JS. Immunodeficiency disorders. Preface. Immunology and Allergy Clinics of North America. 28: xv-xviii. PMID 18424330 DOI: 10.1016/j.iac.2008.02.003  0.96
2008 Madge LA, Kluger MS, Orange JS, May MJ. Lymphotoxin-alpha 1 beta 2 and LIGHT induce classical and noncanonical NF-kappa B-dependent proinflammatory gene expression in vascular endothelial cells. Journal of Immunology (Baltimore, Md. : 1950). 180: 3467-77. PMID 18292573  0.96
2008 LaRosa DF, Orange JS. 1. Lymphocytes Journal of Allergy and Clinical Immunology. 121. PMID 18241683 DOI: 10.1016/j.jaci.2007.06.016  0.96
2008 Salt BH, Niemela JE, Pandey R, Hanson EP, Deering RP, Quinones R, Jain A, Orange JS, Gelfand EW. IKBKG (nuclear factor-kappa B essential modulator) mutation can be associated with opportunistic infection without impairing Toll-like receptor function. The Journal of Allergy and Clinical Immunology. 121: 976-82. PMID 18179816 DOI: 10.1016/j.jaci.2007.11.014  0.96
2008 Rezaei N, Bonilla FA, Sullivan KE, De Vries E, Orange JS. An introduction to primary immunodeficiency diseases Primary Immunodeficiency Diseases: Definition, Diagnosis, and Management. 1-38. DOI: 10.1007/978-3-540-78936-9_1  0.96
2007 Pandey R, DeStephan CM, Madge LA, May MJ, Orange JS. NKp30 ligation induces rapid activation of the canonical NF-kappaB pathway in NK cells. Journal of Immunology (Baltimore, Md. : 1950). 179: 7385-96. PMID 18025182  0.96
2007 Andzelm MM, Chen X, Krzewski K, Orange JS, Strominger JL. Myosin IIA is required for cytolytic granule exocytosis in human NK cells. The Journal of Experimental Medicine. 204: 2285-91. PMID 17875677 DOI: 10.1084/jem.20071143  0.96
2007 Banerjee PP, Pandey R, Zheng R, Suhoski MM, Monaco-Shawver L, Orange JS. Cdc42-interacting protein-4 functionally links actin and microtubule networks at the cytolytic NK cell immunological synapse. The Journal of Experimental Medicine. 204: 2305-20. PMID 17785506 DOI: 10.1084/jem.20061893  0.96
2007 Hakonarson H, Grant SF, Bradfield JP, Marchand L, Kim CE, Glessner JT, Grabs R, Casalunovo T, Taback SP, Frackelton EC, Lawson ML, Robinson LJ, Skraban R, Lu Y, Chiavacci RM, ... ... Orange JS, et al. A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. Nature. 448: 591-4. PMID 17632545 DOI: 10.1038/nature06010  0.96
2007 Onigbanjo MT, Orange JS, Perez EE, Sullivan KE. Hypogammaglobulinemia in a pediatric tertiary care setting. Clinical Immunology (Orlando, Fla.). 125: 52-9. PMID 17631052 DOI: 10.1016/j.clim.2007.05.017  0.96
2007 Veler H, Hu A, Fatma S, Grunstein JS, DeStephan CM, Campbell D, Orange JS, Grunstein MM. Superantigen presentation by airway smooth muscle to CD4+ T lymphocytes elicits reciprocal proasthmatic changes in airway function. Journal of Immunology (Baltimore, Md. : 1950). 178: 3627-36. PMID 17339460  0.96
2007 Chang JT, Palanivel VR, Kinjyo I, Schambach F, Intlekofer AM, Banerjee A, Longworth SA, Vinup KE, Mrass P, Oliaro J, Killeen N, Orange JS, Russell SM, Weninger W, Reiner SL. Asymmetric T lymphocyte division in the initiation of adaptive immune responses. Science (New York, N.Y.). 315: 1687-91. PMID 17332376 DOI: 10.1126/science.1139393  0.96
2007 Solt LA, Madge LA, Orange JS, May MJ. Interleukin-1-induced NF-kappaB activation is NEMO-dependent but does not require IKKbeta. The Journal of Biological Chemistry. 282: 8724-33. PMID 17244613 DOI: 10.1074/jbc.M609613200  0.96
2007 Hirschfeld AF, Bettinger JA, Victor RE, Davidson DJ, Currie AJ, Ansermino JM, Scheifele DW, Orange JS, Turvey SE. Prevalence of Toll-like receptor signalling defects in apparently healthy children who developed invasive pneumococcal infection. Clinical Immunology (Orlando, Fla.). 122: 271-8. PMID 17157070 DOI: 10.1016/j.clim.2006.10.012  0.96
2007 Orange JS. The lytic NK cell immunological synapse and sequential steps in its formation Advances in Experimental Medicine and Biology. 601: 225-233. DOI: 10.1007/978-0-387-72005-0_23  0.96
2006 Dorsey MJ, Orange JS. Impaired specific antibody response and increased B-cell population in transient hypogammaglobulinemia of infancy Annals of Allergy, Asthma and Immunology. 97: 590-595. PMID 17165264  0.96
2006 Orange JS. Human natural killer cell deficiencies Current Opinion in Allergy and Clinical Immunology. 6: 399-409. PMID 17088643 DOI: 10.1097/ACI.0b013e3280106b65  0.96
2006 Krzewski K, Chen X, Orange JS, Strominger JL. Formation of a WIP-, WASp-, actin-, and myosin IIA-containing multiprotein complex in activated NK cells and its alteration by KIR inhibitory signaling. The Journal of Cell Biology. 173: 121-32. PMID 16606694 DOI: 10.1083/jcb.200509076  0.96
2006 Orange JS, Hossny EM, Weiler CR, Ballow M, Berger M, Bonilla FA, Buckley R, Chinen J, El-Gamal Y, Mazer BD, Nelson RP, Patel DD, Secord E, Sorensen RU, Wasserman RL, et al. Use of intravenous immunoglobulin in human disease: a review of evidence by members of the Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and Immunology. The Journal of Allergy and Clinical Immunology. 117: S525-53. PMID 16580469 DOI: 10.1016/j.jaci.2006.01.015  0.96
2006 Deering RP, Orange JS. Development of a clinical assay to evaluate toll-like receptor function. Clinical and Vaccine Immunology : Cvi. 13: 68-76. PMID 16426002 DOI: 10.1128/CVI.13.1.68-76.2006  0.96
2006 Orange JS, Ballas ZK. Natural killer cells in human health and disease Clinical Immunology. 118: 1-10. PMID 16337194 DOI: 10.1016/j.clim.2005.10.011  0.96
2005 Intlekofer AM, Takemoto N, Wherry EJ, Longworth SA, Northrup JT, Palanivel VR, Mullen AC, Gasink CR, Kaech SM, Miller JD, Gapin L, Ryan K, Russ AP, Lindsten T, Orange JS, et al. Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nature Immunology. 6: 1236-44. PMID 16273099 DOI: 10.1038/ni1268  0.96
2005 Bonilla FA, Bernstein IL, Khan DA, Ballas ZK, Chinen J, Frank MM, Kobrynski LJ, Levinson AI, Mazer B, Nelson RP, Orange JS, Routes JM, Shearer WT, Sorensen RU, et al. Practice parameter for the diagnosis and management of primary immunodeficiency. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology. 94: S1-63. PMID 15945566  0.96
2005 Orange JS. Congenital immunodeficiencies and sepsis Pediatric Critical Care Medicine. 6. PMID 15857568 DOI: 10.1097/01.PCC.0000164488.19810.DB  0.96
2005 Orange JS, Levy O, Geha RS. Human disease resulting from gene mutations that interfere with appropriate nuclear factor-kappaB activation. Immunological Reviews. 203: 21-37. PMID 15661019 DOI: 10.1111/j.0105-2896.2005.00221.x  0.96
2004 Simons FER, Peng Z, Orange JS, Schneider LC. Early-onset cellulitis after insect bites: Allergic inflammation (multiple letters) Annals of Allergy, Asthma and Immunology. 93: 606-607. PMID 15609773  0.96
2004 Jain A, Ma CA, Lopez-Granados E, Means G, Brady W, Orange JS, Liu S, Holland S, Derry JMJ. Specific NEMO mutations impair CD40-mediated c-Rel activation and B cell terminal differentiation Journal of Clinical Investigation. 114: 1593-1602. PMID 15578091 DOI: 10.1172/JCI200421345  0.96
2004 Dai YS, Liang MG, Gellis SE, Bonilla FA, Schneider LC, Geha RS, Orange JS. Characteristics of mycobacterial infection in patients with immunodeficiency and nuclear factor-kappaB essential modulator mutation, with or without ectodermal dysplasia. Journal of the American Academy of Dermatology. 51: 718-22. PMID 15523349 DOI: 10.1016/j.jaad.2004.05.032  0.96
2004 Orange JS, Stone KD, Turvey SE, Krzewski K. The Wiskott-Aldrich syndrome Cellular and Molecular Life Sciences. 61: 2361-2385. PMID 15378206 DOI: 10.1007/s00018-004-4086-z  0.96
2004 Orange JS, Levy O, Brodeur SR, Krzewski K, Roy RM, Niemela JE, Fleisher TA, Bonilla FA, Geha RS. Human nuclear factor kappa B essential modulator mutation can result in immunodeficiency without ectodermal dysplasia. The Journal of Allergy and Clinical Immunology. 114: 650-6. PMID 15356572 DOI: 10.1016/j.jaci.2004.06.052  0.96
2004 Li Y, Zhang T, Ho C, Orange JS, Douglas SD, Ho WZ. Natural killer cells inhibit hepatitis C virus expression Journal of Leukocyte Biology. 76: 1171-1179. PMID 15339939 DOI: 10.1189/jlb.0604372  0.96
2004 Orange JS, Jain A, Ballas ZK, Schneider LC, Geha RS, Bonilla FA. The presentation and natural history of immunodeficiency caused by nuclear factor kappaB essential modulator mutation. The Journal of Allergy and Clinical Immunology. 113: 725-33. PMID 15100680 DOI: 10.1016/j.jaci.2004.01.762  0.96
2004 Orange JS, Song LA, Twarog FJ, Schneider LC. A patient with severe black fly (Simuliidae) hypersensitivity referred for evaluation of suspected immunodeficiency Annals of Allergy, Asthma and Immunology. 92: 276-280. PMID 14989400  0.96
2003 MacGinnitie AJ, Walensky LD, Turvey SE, Orange JS, Bonilla FA, Silverman LB, Oettgen H. Management of an anaphylactoid reaction to methotrexate with a stepwise graded challenge. Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology. 14: 409-11. PMID 14641613 DOI: 10.1034/j.1399-3038.2003.00073.x  0.96
2003 Orange JS, Harris KE, Andzelm MM, Valter MM, Geha RS, Strominger JL. The mature activating natural killer cell immunologic synapse is formed in distinct stages. Proceedings of the National Academy of Sciences of the United States of America. 100: 14151-6. PMID 14612578 DOI: 10.1073/pnas.1835830100  0.96
2003 Koopman LA, Kopcow HD, Rybalov B, Boyson JE, Orange JS, Schatz F, Masch R, Lockwood CJ, Schachter AD, Park PJ, Strominger JL. Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential. The Journal of Experimental Medicine. 198: 1201-12. PMID 14568979 DOI: 10.1084/jem.20030305  0.96
2003 Orange JS, Geha RS. Finding NEMO: Genetic disorders of NF-κB activation Journal of Clinical Investigation. 112: 983-985. PMID 14523034 DOI: 10.1172/JCI200319960  0.96
2003 Levy O, Orange JS, Hibberd P, Steinberg S, LaRussa P, Weinberg A, Wilson SB, Shaulov A, Fleisher G, Geha RS, Bonilla FA, Exley M. Disseminated varicella infection due to the vaccine strain of varicella-zoster virus, in a patient with a novel deficiency in natural killer T cells. The Journal of Infectious Diseases. 188: 948-53. PMID 14513412 DOI: 10.1086/378503  0.96
2003 Orange JS, Geha RS, Bonilla FA. Acute chylothorax in children: selective retention of memory T cells and natural killer cells. The Journal of Pediatrics. 143: 243-9. PMID 12970641 DOI: 10.1067/S0022-3476(03)00305-6  0.96
2002 Orange JS. Human natural killer cell deficiencies and susceptibility to infection Microbes and Infection. 4: 1545-1558. PMID 12505527 DOI: 10.1016/S1286-4579(02)00038-2  0.96
2002 Orange JS, Fassett MS, Koopman LA, Boyson JE, Strominger JL. Viral evasion of natural killer cells. Nature Immunology. 3: 1006-12. PMID 12407408 DOI: 10.1038/ni1102-1006  0.96
2002 Orange JS, Ramesh N, Remold-O'Donnell E, Sasahara Y, Koopman L, Byrne M, Bonilla FA, Rosen FS, Geha RS, Strominger JL. Wiskott-Aldrich syndrome protein is required for NK cell cytotoxicity and colocalizes with actin to NK cell-activating immunologic synapses. Proceedings of the National Academy of Sciences of the United States of America. 99: 11351-6. PMID 12177428 DOI: 10.1073/pnas.162376099  0.96
2002 Orange JS, Brodeur SR, Jain A, Bonilla FA, Schneider LC, Kretschmer R, Nurko S, Rasmussen WL, Köhler JR, Gellis SE, Ferguson BM, Strominger JL, Zonana J, Ramesh N, Ballas ZK, et al. Deficient natural killer cell cytotoxicity in patients with IKK-gamma/NEMO mutations. The Journal of Clinical Investigation. 109: 1501-9. PMID 12045264 DOI: 10.1172/JCI14858  0.96
2001 Orange JS, Chehimi J, Ghavimi D, Campbell D, Sullivan KE. Decreased natural killer (NK) cell function in chronic NK cell lymphocytosis associated with decreased surface expression of CD11b Clinical Immunology. 99: 53-64. PMID 11286541 DOI: 10.1006/clim.2001.5002  0.96
1998 Salazar-Mather TP, Orange JS, Biron CA. Early murine cytomegalovirus (MCMV) infection induces liver natural killer (NK) cell inflammation and protection through macrophage inflammatory protein 1α (MIP-1α)-dependent pathways Journal of Experimental Medicine. 187: 1-14. PMID 9419206 DOI: 10.1084/jem.187.1.1  0.96
1997 Orange JS, Salazar-Mather TP, Opal SM, Biron CA. Mechanisms for virus-induced liver disease: Tumor necrosis factor- mediated pathology independent of natural killer and T cells during murine cytomegalovirus infection Journal of Virology. 71: 9248-9258. PMID 9371583  0.96
1997 Cousens LP, Orange JS, Su HC, Biron CA. Interferon-α/β inhibition of interleukin 12 and interferon-γ production in vitro and endogenously during viral infection Proceedings of the National Academy of Sciences of the United States of America. 94: 634-639. PMID 9012836 DOI: 10.1073/pnas.94.2.634  0.96
1996 Wang B, Holländer GA, Nichogiannopoulou A, Simpson SJ, Orange JS, Gutierrez-Ramos JC, Burakoff SJ, Biron CA, Terhorst C. Natural killer cell development is blocked in the context of aberrant T lymphocyte ontogeny International Immunology. 8: 939-949. PMID 8671683 DOI: 10.1093/intimm/8.6.939  0.96
1996 Orange JS, Biron CA. Characterization of early IL-12, IFN-αβ, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection Journal of Immunology. 156: 4746-4756. PMID 8648121  0.96
1996 Orange JS, Biron CA. An absolute and restricted requirement for IL-12 in natural killer cell IFN-γ production and antiviral defense: Studies of natural killer and T cell responses in contrasting viral infections Journal of Immunology. 156: 1138-1142. PMID 8557990  0.96
1996 Biron CA, Su HC, Orange JS. Function and regulation of natural killer (NK) cells during viral infections: Characterization of responses in vivo Methods: a Companion to Methods in Enzymology. 9: 379-393. DOI: 10.1006/meth.1996.0043  0.96
1996 Cousens LP, Orange JS, Su HC, Biron CA. IFN-a/β inhibition of IL-12 and IFN-y production Faseb Journal. 10.  0.96
1995 Biron CA, Orange JS. IL 12 in acute viral infectious disease Research in Immunology. 146: 590-600. PMID 8839166 DOI: 10.1016/0923-2494(96)83036-7  0.96
1995 Orange JS, Salazar-Mather TP, Opal SM, Spencer RL, Miller AH, McEwen BS, Biron CA. Mechanism of interleukin 12-mediated toxicities during experimental viral infections: role of tumor necrosis factor and glucocorticoids. The Journal of Experimental Medicine. 181: 901-14. PMID 7869050 DOI: 10.1084/jem.181.3.901  0.96
1995 Orange JS, Wang B, Terhorst C, Biron CA. Requirement for natural killer cell-produced interferon γ in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration Journal of Experimental Medicine. 182: 1045-1056. PMID 7561678 DOI: 10.1084/jem.182.4.1045  0.96
1995 Cousens LP, Orange JS, Biron CA. Endogenous IL-2 contributes to T cell expansion and IFN-γ production during lymphocytic choriomeningitis virus infection Journal of Immunology. 155: 5690-5699. PMID 7499855  0.96
1994 Su HC, Orange JS, Fast LD, Chan AT, Simpson SJ, Terhorst C, Biron CA. IL-2-dependent NK cell responses discovered in virus-infected β2-microglobulin-deficient mice Journal of Immunology. 153: 5674-5681. PMID 7989765  0.96
1994 Orange JS, Wolf SF, Biron CA. Effects of IL-12 on the response and susceptibility to experimental viral infections Journal of Immunology. 152: 1253-1264. PMID 7905500  0.96
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