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Daniel J. Rader - Publications

Affiliations: 
Cell and Molecular Biology University of Pennsylvania, Philadelphia, PA, United States 
Area:
Molecular Biology
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Year Citation  Score
2023 Nagai TH, Hartigan C, Mizoguchi T, Yu H, Deik A, Bullock K, Wang Y, Cromley D, Schenone M, Cowan CA, Rader DJ, Clish CB, Carr SA, Xu YX. Chromatin regulator SMARCAL1 modulates cellular lipid metabolism. Communications Biology. 6: 1298. PMID 38129665 DOI: 10.1038/s42003-023-05665-6  0.315
2023 Schneider CV, Hehl L, Creasy KT, Vitali C, Vell MS, Vujkovic M, Park J, Scorletti E, Seeling KS, Rendel MD, Conlon DM, Huang H, Zandvakili I, Valmiki S, Schneider KM, ... ... Rader DJ, et al. A coding variant in the microsomal triglyceride transfer protein reduces both hepatic steatosis and plasma lipids. Alimentary Pharmacology & Therapeutics. PMID 37248657 DOI: 10.1111/apt.17566  0.303
2023 Gawronski KAB, Bone WP, Park Y, Pashos EE, Wenz BM, Dudek MF, Wang X, Yang W, Rader DJ, Musunuru K, Voight BF, Brown CD. Evaluating the Contribution of Cell Type-Specific Alternative Splicing to Variation in Lipid Levels. Circulation. Genomic and Precision Medicine. e003249. PMID 37165871 DOI: 10.1161/CIRCGEN.120.003249  0.301
2023 Choi D, Malick WA, Koenig W, Rader DJ, Rosenson RS. Familial Hypercholesterolemia: Challenges for a High-Risk Population: JACC Focus Seminar 1/3. Journal of the American College of Cardiology. 81: 1621-1632. PMID 37076217 DOI: 10.1016/j.jacc.2023.02.038  0.328
2022 Ko YA, Billheimer JT, Lyssenko NN, Kueider-Paisley A, Wolk DA, Arnold SE, Leung YY, Shaw LM, Trojanowski JQ, Kaddurah-Daouk RF, Kling MA, Rader DJ. ApoJ/Clusterin concentrations are determinants of cerebrospinal fluid cholesterol efflux capacity and reduced levels are associated with Alzheimer's disease. Alzheimer's Research & Therapy. 14: 194. PMID 36572909 DOI: 10.1186/s13195-022-01119-z  0.301
2022 Nasr A, Matthews KA, Brooks MM, Barinas-Mitchell E, Orchard T, Billheimer J, Wang NC, McConnell D, Rader DJ, El Khoudary SR. Early Midlife Cardiovascular Health Influences Future HDL Metrics in Women: The SWAN HDL Study. Journal of the American Heart Association. 11: e026243. PMID 36285790 DOI: 10.1161/JAHA.122.026243  0.324
2022 Bi X, Stankov S, Lee PC, Wang Z, Wu X, Li L, Ko YA, Cheng L, Zhang H, Hand NJ, Rader DJ. ILRUN Promotes Atherosclerosis Through Lipid-Dependent and Lipid-Independent Factors. Arteriosclerosis, Thrombosis, and Vascular Biology. 101161ATVBAHA1213171. PMID 35861973 DOI: 10.1161/ATVBAHA.121.317156  0.311
2022 Picataggi A, Rodrigues A, Cromley DA, Wang H, Wiener JP, Garliyev V, Billheimer JT, Grabiner BC, Hurt JA, Chen AC, Han X, Rader DJ, Praticò D, Lyssenko NN. Specificity of ABCA7-mediated cell lipid efflux. Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. 1867: 159157. PMID 35381375 DOI: 10.1016/j.bbalip.2022.159157  0.326
2022 Clarke SL, Tcheandjieu C, Hilliard AT, Lee M, Lynch J, Chang KM, Miller D, Knowles JW, O'Donnell C, Tsao P, Rader DJ, Wilson PW, Sun YV, Gaziano M, Assimes TL. Coronary Artery Disease Risk of Familial Hypercholesterolemia Genetic Variants Independent of Clinically Observed Longitudinal Cholesterol Exposure. Circulation. Genomic and Precision Medicine. CIRCGEN121003501. PMID 35143253 DOI: 10.1161/CIRCGEN.121.003501  0.306
2021 Hancock-Cerutti W, Millar JS, Valentini S, Liu J, Billheimer JT, Rader DJ, Cuchel M. Assessing HDL Metabolism in Subjects with Elevated Levels of HDL Cholesterol and Coronary Artery Disease. Molecules (Basel, Switzerland). 26. PMID 34833954 DOI: 10.3390/molecules26226862  0.359
2021 Quiroz-Figueroa K, Vitali C, Conlon DM, Millar JS, Tobias JW, Bauer RC, Hand NJ, Rader DJ. TRIB1 regulates LDL metabolism through CEBPα-mediated effects on the LDL receptor in hepatocytes. The Journal of Clinical Investigation. 131. PMID 34779419 DOI: 10.1172/JCI146775  0.349
2021 Polla DL, Edmondson AC, Duvet S, March ME, Sousa AB, Lehman A, Niyazov D, van Dijk F, Demirdas S, van Slegtenhorst MA, Kievit AJA, Schulz C, Armstrong L, Bi X, ... Rader DJ, et al. Bi-allelic variants in the ER quality control mannosidase gene EDEM3 cause a congenital disorder of glycosylation. American Journal of Human Genetics. PMID 34143952 DOI: 10.1016/j.ajhg.2021.05.010  0.61
2020 El Khoudary SR, Chen X, Nasr A, Billheimer J, Brooks MM, McConnell D, Orchard T, Crawford S, Matthews KA, Rader DJ. HDL (High-Density Lipoprotein) Subclasses, Lipid Content, and Function Trajectories Across the Menopause Transition: SWAN-HDL Study. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA120315355. PMID 33267661 DOI: 10.1161/ATVBAHA.120.315355  0.328
2020 Bi X, Kuwano T, Lee PC, Millar JS, Li L, Shen Y, Soccio RE, Hand NJ, Rader DJ. ILRUN, a Human Plasma Lipid GWAS Locus, Regulates Lipoprotein Metabolism in Mice. Circulation Research. PMID 32912065 DOI: 10.1161/Circresaha.120.317175  0.443
2020 Nomura A, Emdin CA, Won HH, Peloso GM, Natarajan P, Ardissino D, Danesh J, Schunkert H, Correa A, Bown MJ, Samani NJ, Erdmann J, McPherson R, Watkins H, Saleheen D, ... ... Rader DJ, et al. Heterozygous ATP-binding Cassette Transporter G5 Gene Deficiency and Risk of Coronary Artery Disease. Circulation. Genomic and Precision Medicine. PMID 32862661 DOI: 10.1161/CIRCGEN.119.002871  0.327
2020 Small AM, Huffman JE, Klarin D, Sabater-Lleal M, Lynch JA, Assimes TL, Sun YV, Miller D, Freiberg MS, Morrison AC, Rader DJ, Wilson PWF, Cho K, Tsao PS, Chang KM, et al. Mendelian Randomization Analysis of Hemostatic Factors and Their Contribution to Peripheral Artery Disease. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA119313847. PMID 32847391 DOI: 10.1161/Atvbaha.119.313847  0.311
2020 Wu L, Soundarapandian MM, Castoreno AB, Millar JS, Rader DJ. LDL-Cholesterol Reduction by ANGPTL3 Inhibition in Mice Is Dependent on Endothelial Lipase. Circulation Research. PMID 32808882 DOI: 10.1161/Circresaha.120.317128  0.384
2020 Ajala ON, Demler OV, Liu Y, Farukhi Z, Adelman SJ, Collins HL, Ridker PM, Rader DJ, Glynn RJ, Mora S. Anti-Inflammatory HDL Function, Incident Cardiovascular Events, and Mortality: A Secondary Analysis of the JUPITER Randomized Clinical Trial. Journal of the American Heart Association. e016507. PMID 32799709 DOI: 10.1161/Jaha.119.016507  0.39
2020 Nasr A, Matthews KA, Brooks MM, McConnell DS, Orchard TJ, Billheimer J, Rader DJ, El Khoudary SR. Vasomotor symptoms and lipids/lipoprotein subclass metrics in midlife women: Does level of endogenous estradiol matter? The SWAN HDL Ancillary Study. Journal of Clinical Lipidology. PMID 32747311 DOI: 10.1016/J.Jacl.2020.07.002  0.43
2020 Vujkovic M, Keaton JM, Lynch JA, Miller DR, Zhou J, Tcheandjieu C, Huffman JE, Assimes TL, Lorenz K, Zhu X, Hilliard AT, Judy RL, Huang J, Lee KM, Klarin D, ... ... Rader DJ, et al. Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis. Nature Genetics. PMID 32541925 DOI: 10.1038/S41588-020-0637-Y  0.341
2020 Aragam KG, Dobbyn A, Judy R, Chaffin M, Chaudhary K, Hindy G, Cagan A, Finneran P, Weng LC, Loos RJF, Nadkarni G, Cho JH, Kember RL, Baras A, Reid J, ... ... Rader DJ, et al. Limitations of Contemporary Guidelines for Managing Patients at High Genetic Risk of Coronary Artery Disease. Journal of the American College of Cardiology. 75: 2769-2780. PMID 32498804 DOI: 10.1016/J.Jacc.2020.04.027  0.325
2020 Zilmer M, Edmondson AC, Khetarpal SA, Alesi V, Zaki MS, Rostasy K, Madsen CG, Lepri FR, Sinibaldi L, Cusmai R, Novelli A, Issa MY, Fenger CD, Abou Jamra R, Reutter H, ... ... Rader DJ, et al. Novel congenital disorder of O-linked glycosylation caused by GALNT2 loss of function. Brain : a Journal of Neurology. PMID 32293671 DOI: 10.1093/Brain/Awaa063  0.613
2020 Ueda M, Wolska A, Burke FM, Escobar M, Walters L, Lalic D, Hegele RA, Remaley AT, Rader DJ, Dunbar RL. Experimental Therapeutics for Challenging Clinical Care of a Patient with an Extremely Rare Homozygous Mutation. Case Reports in Endocrinology. 2020: 1865489. PMID 32292609 DOI: 10.1155/2020/1865489  0.307
2020 Bajaj A, Rader DJ. Antisense oligonucleotides for atherosclerotic disease. Nature Medicine. 26: 471-472. PMID 32251402 DOI: 10.1038/S41591-020-0835-2  0.322
2020 Bajaj A, Ihegword A, Qiu C, Small AM, Wei WQ, Bastarache L, Feng Q, Kember RL, Risman M, Bloom RD, Birtwell DL, Williams H, Shaffer CM, Chen J, Center RG, ... ... Rader DJ, et al. Phenome-wide association analysis suggests the APOL1 linked disease spectrum primarily drives kidney-specific pathways. Kidney International. PMID 32247630 DOI: 10.1016/J.Kint.2020.01.027  0.312
2020 Chirinos JA, Zhao L, Jia Y, Frej C, Adamo L, Mann D, Shewale SV, Millar JS, Rader DJ, French B, Brandimarto J, Margulies KB, Parks JS, Wang Z, Sieffert DA, et al. Reduced Apolipoprotein M and Adverse Outcomes Across the Spectrum of Human Heart Failure. Circulation. PMID 32237898 DOI: 10.1161/Circulationaha.119.045323  0.345
2020 Xu YX, Peloso GM, Nagai TH, Mizoguchi T, Deik A, Bullock K, Lin H, Musunuru K, Yang Q, Vasan RS, Gerszten RE, Clish CB, Rader D, Kathiresan S. EDEM3 Modulates Plasma Triglyceride Level through Its Regulation of LRP1 Expression. Iscience. 23: 100973. PMID 32213464 DOI: 10.1016/J.Isci.2020.100973  0.396
2020 Doshi JA, Li P, Puckett JT, Pettit AR, Raman S, Parmacek MS, Rader DJ. Trends and Factors Associated With Insurer Approval of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor Prescriptions. Value in Health : the Journal of the International Society For Pharmacoeconomics and Outcomes Research. 23: 209-216. PMID 32113626 DOI: 10.1016/J.Jval.2019.08.011  0.306
2020 Cipollari E, Szapary HJ, Picataggi A, Billheimer JT, Lyssenko CA, Ying GS, Shaw LM, Kling MA, Kaddurah-Daouk R, Rader DJ, Praticò D, Lyssenko NN. Correlates and Predictors of Cerebrospinal Fluid Cholesterol Efflux Capacity from Neural Cells, a Family of Biomarkers for Cholesterol Epidemiology in Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 32065798 DOI: 10.3233/Jad-191246  0.354
2020 Nurnberg ST, Guerraty MA, Wirka RC, Rao HS, Pjanic M, Norton S, Serrano F, Perisic L, Elwyn S, Pluta J, Zhao W, Testa S, Park Y, Nguyen T, Ko YA, ... ... Rader DJ, et al. Genomic profiling of human vascular cells identifies TWIST1 as a causal gene for common vascular diseases. Plos Genetics. 16: e1008538. PMID 31917787 DOI: 10.1371/Journal.Pgen.1008538  0.344
2020 Ueda M, McIntyre AD, Remaley AT, Hegele RA, Rader DJ. SUN-593 Variants in Known Monogenic Causal Genes of Hypertriglyceridemia Are Not Major Contributors for Hypertriglyceridemia in Lipodystrophy Due to a LMNA Mutation Journal of the Endocrine Society. 4. DOI: 10.1210/Jendso/Bvaa046.103  0.379
2020 Ueda M, Wolska A, Sampson M, Burke FM, Rader DJ, Dunbar RL, Remaley AT. SAT-578 A Rare Case of Laboratory Hypertriglyceridemia: Glycerol Kinase Deficiency Journal of the Endocrine Society. 4. DOI: 10.1210/Jendso/Bvaa046.075  0.354
2020 Khoudary SRE, Nasr A, Chen X, Matthews KA, Orchard T, Brooks MM, Billheimer J, McConnell D, Janssen I, Everson-rose SA, Martin D, Rader D. Abstract P401: Associations Between High-density Lipoprotein Subclasses and Coronary Artery Calcification Vary by Menopausal Stage. The Study of Women's Health Across the Nation Hdl Ancillary Study Circulation. 141. DOI: 10.1161/Circ.141.Suppl_1.P401  0.348
2020 Sheth S, Cuccolo N, Vassalo R, Blaine N, Wharton D, Favatella J, Hossain E, Hajj J, Webb G, Bajaj A, Soffer D, Rader D, Jacoby D. Clinical Use, Insurance Approval, And Lipid Lowering Of Pcsk9 Inhibitors In A Large Health System Journal of the American College of Cardiology. 75: 1839. DOI: 10.1016/S0735-1097(20)32466-9  0.318
2020 Ueda M, Goel H, Lalic D, Pollan L, Nathanson G, Hoque J, Escobar M, Rader D, Dunbar R. Contrasting Postprandial Triglyceride Response of Two Niacin Formulations and Regimen To Modify Coronary Heart Disease Risk Journal of Clinical Lipidology. 14: 566-567. DOI: 10.1016/J.Jacl.2020.05.038  0.313
2019 Johnston JM, Angyal A, Bauer RC, Hamby S, Suvarna SK, Baidžajevas K, Hegedus Z, Dear TN, Turner M, Wilson HL, Goodall AH, Rader DJ, Shoulders CC, Francis SE, et al. Myeloid Tribbles 1 induces early atherosclerosis via enhanced foam cell expansion. Science Advances. 5: eaax9183. PMID 31692955 DOI: 10.1126/Sciadv.Aax9183  0.418
2019 Klarin D, Busenkell E, Judy R, Lynch J, Levin M, Haessler J, Aragam K, Chaffin M, Haas M, Lindström S, Assimes TL, Huang J, Min Lee K, Shao Q, Huffman JE, ... ... Rader DJ, et al. Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease. Nature Genetics. PMID 31676865 DOI: 10.1038/S41588-019-0519-3  0.323
2019 Duell PB, Gidding SS, Andersen RL, Knickelbine T, Anderson L, Gianos E, Shrader P, Kindt I, O'Brien EC, McCann D, Hemphill LC, Ahmed CD, Martin SS, Larry JA, Ahmad ZS, ... ... Rader DJ, et al. Longitudinal low density lipoprotein cholesterol goal achievement and cardiovascular outcomes among adult patients with familial hypercholesterolemia: The CASCADE FH registry. Atherosclerosis. 289: 85-93. PMID 31487564 DOI: 10.1016/J.Atherosclerosis.2019.08.007  0.339
2019 Bick AG, Akwo E, Robinson-Cohen C, Lee K, Lynch J, Assimes TL, DuVall S, Edwards T, Fang H, Freiberg SM, Giri A, Huffman JE, Huang J, Hull L, Kember RL, ... ... Rader DJ, et al. Association of APOL1 Risk Alleles with Cardiovascular Disease in African Americans in the Million Veteran Program. Circulation. PMID 31337231 DOI: 10.1161/Circulationaha.118.036589  0.307
2019 Myers KD, Farboodi N, Mwamburi M, Howard W, Staszak D, Gidding S, Baum SJ, Wilemon K, Rader DJ. Effect of Access to Prescribed PCSK9 Inhibitors on Cardiovascular Outcomes. Circulation. Cardiovascular Quality and Outcomes. 12: e005404. PMID 31331194 DOI: 10.1161/Circoutcomes.118.005404  0.386
2019 Klarin D, Lynch J, Aragam K, Chaffin M, Assimes TL, Huang J, Lee KM, Shao Q, Huffman JE, Natarajan P, Arya S, Small A, Sun YV, Vujkovic M, Freiberg MS, ... ... Rader DJ, et al. Genome-wide association study of peripheral artery disease in the Million Veteran Program. Nature Medicine. PMID 31285632 DOI: 10.1038/S41591-019-0492-5  0.405
2019 Çalışkan M, Manduchi E, Rao HS, Segert JA, Beltrame MH, Trizzino M, Park Y, Baker SW, Chesi A, Johnson ME, Hodge KM, Leonard ME, Loza B, Xin D, Berrido AM, ... ... Rader DJ, et al. Genetic and Epigenetic Fine Mapping of Complex Trait Associated Loci in the Human Liver. American Journal of Human Genetics. PMID 31204013 DOI: 10.1016/J.Ajhg.2019.05.010  0.3
2019 Müller-Wieland D, Rader DJ, Moriarty PM, Bergeron J, Langslet G, Ray KK, Manvelian G, Thompson D, Bujas-Bobanovic M, Roth EM. Efficacy and Safety of Alirocumab 300 mg Every 4 Weeks in Individuals with Type 2 Diabetes on Maximally Tolerated Statin. The Journal of Clinical Endocrinology and Metabolism. PMID 31166599 DOI: 10.1210/Jc.2018-02703  0.315
2019 van den Boogert MAW, Larsen LE, Ali L, Kuil SD, Chong PLW, Loregger A, Kroon J, Schnitzler JG, Schimmel AWM, Peter J, Levels JHM, Steenbergen G, Morava E, Dallinga-Thie GM, Wevers RA, ... ... Rader DJ, et al. N-Glycosylation Defects in Man Lower LDL-Cholesterol Through Increased LDL Receptor Expression. Circulation. PMID 31117816 DOI: 10.1161/Circulationaha.118.036484  0.373
2019 Bajaj A, Xie D, Cedillo-Couvert E, Charleston J, Chen J, Deo R, Feldman HI, Go AS, He J, Horwitz E, Kallem R, Rahman M, Weir MR, Anderson AH, Rader DJ, et al. Lipids, Apolipoproteins, and Risk of Atherosclerotic Cardiovascular Disease in Persons With CKD. American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation. PMID 30686529 DOI: 10.1053/J.Ajkd.2018.11.010  0.353
2019 Penson P, Long DL, Howard G, Howard VJ, Jones SR, Martin SS, Mikhailidis DP, Muntner P, Rizzo M, Rader DJ, Safford MM, Sahebkar A, Toth PP, Banach M. Associations between cardiovascular disease, cancer, and very low high-density lipoprotein cholesterol in the REasons for Geographical and Racial Differences in Stroke (REGARDS) study. Cardiovascular Research. 115: 204-212. PMID 30576432 DOI: 10.1093/Cvr/Cvy198  0.412
2019 Sheth S, Risman M, Rader D, Jacoby D. Abstract P109: Hypertension in a Large Cohort of Patients With Lipoprotein(a) at a Tertiary Academic Center Hypertension. 74. DOI: 10.1161/Hyp.74.Suppl_1.P109  0.346
2019 Guerraty M, Ko Y, Levin M, Haury W, Damrauer S, Rader D. Genotype-First Approach Shows Fog2/Zfpm2 Is Associated With Coronary Microvascular Disease Journal of the American College of Cardiology. 73: 31. DOI: 10.1016/S0735-1097(19)30640-0  0.315
2019 Kember R, Ji X, Zhang J, Brown C, Rader D, Almasy L, Bucan M. Spectrum Of Common And Rare Mutations Contributing To Autism Risk In Families European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2017.08.322  0.303
2019 Parker MM, Damrauer SM, Rader DJ, Ticau S, Erbe D, Hinkle G, Nioi P. The V122I Mutation in Hereditary Transthyretin-Mediated Amyloidosis is Significantly Associated with Polyneuropathy Journal of Cardiac Failure. 25: S110. DOI: 10.1016/J.Cardfail.2019.07.314  0.314
2018 Sun YV, Damrauer SM, Hui Q, Assimes TL, Ho YL, Natarajan P, Klarin D, Huang J, Lynch J, DuVall SL, Pyarajan S, Honerlaw JP, Gaziano JM, Cho K, Rader DJ, et al. Effects of Genetic Variants Associated with Familial Hypercholesterolemia on Low-Density Lipoprotein-Cholesterol Levels and Cardiovascular Outcomes in the Million Veteran Program. Circulation. Genomic and Precision Medicine. 11. PMID 31106297 DOI: 10.1161/CIRCGEN.118.002192  0.335
2018 Khoshnejad M, Patel A, Wojtak K, Kudchodkar SB, Humeau L, Lyssenko NN, Rader DJ, Muthumani K, Weiner DB. Development of Novel DNA-Encoded PCSK9 Monoclonal Antibodies as Lipid-Lowering Therapeutics. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 30449662 DOI: 10.1016/J.Ymthe.2018.10.016  0.436
2018 Tuteja S, Qu L, Vujkovic M, Dunbar RL, Chen J, DerOhannessian S, Rader DJ. Genetic Variants Associated With Plasma Lipids Are Associated With the Lipid Response to Niacin. Journal of the American Heart Association. 7: e03488. PMID 30371334 DOI: 10.1161/Jaha.117.008461  0.453
2018 Iqbal J, Walsh MT, Hammad SM, Cuchel M, Rader DJ, Hussain MM. ATP binding cassette family A protein 1 determines hexosylceramide and sphingomyelin levels in human and mouse plasma. Journal of Lipid Research. PMID 30279221 DOI: 10.1194/Jlr.M087502  0.333
2018 Klarin D, Damrauer SM, Cho K, Sun YV, Teslovich TM, Honerlaw J, Gagnon DR, DuVall SL, Li J, Peloso GM, Chaffin M, Small AM, Huang J, Tang H, Lynch JA, ... ... Rader DJ, et al. Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program. Nature Genetics. PMID 30275531 DOI: 10.1038/S41588-018-0222-9  0.364
2018 Liu B, Pjanic M, Wang T, Nguyen T, Gloudemans M, Rao A, Castano VG, Nurnberg S, Rader DJ, Elwyn S, Ingelsson E, Montgomery SB, Miller CL, Quertermous T. Genetic Regulatory Mechanisms of Smooth Muscle Cells Map to Coronary Artery Disease Risk Loci. American Journal of Human Genetics. PMID 30146127 DOI: 10.1016/J.Ajhg.2018.08.001  0.345
2018 Lyssenko NN, Haider N, Picataggi A, Cipollari E, Jiao W, Phillips MC, Rader DJ, Chavali VRM. Directional ABCA1-mediated cholesterol efflux and apoB-lipoprotein secretion in the retinal pigment epithelium. Journal of Lipid Research. PMID 30076206 DOI: 10.1194/Jlr.M087361  0.339
2018 Lyssenko NN, Haider N, Picataggi A, Cipollari E, Jiao W, Phillips MC, Rader DJ, Chavali VRM. Directional ABCA1-mediated cholesterol efflux and apoB-lipoprotein secretion in the retinal pigment epithelium. Journal of Lipid Research. PMID 30076206 DOI: 10.1194/Jlr.M087361  0.339
2018 Sturm AC, Knowles JW, Gidding SS, Ahmad ZS, Ahmed CD, Ballantyne CM, Baum SJ, Bourbon M, Carrié A, Cuchel M, de Ferranti SD, Defesche JC, Freiberger T, Hershberger RE, Hovingh GK, ... ... Rader DJ, et al. Clinical Genetic Testing for Familial Hypercholesterolemia: JACC Scientific Expert Panel. Journal of the American College of Cardiology. 72: 662-680. PMID 30071997 DOI: 10.1016/J.Jacc.2018.05.044  0.352
2018 Rader DJ. Apolipoprotein A-I Infusion Therapies for Coronary Disease: Two Outs in the Ninth Inning and Swinging for the Fences. Jama Cardiology. PMID 30046821 DOI: 10.1001/Jamacardio.2018.2168  0.304
2018 Khetarpal SA, Babb PL, Zhao W, Hancock-Cerutti WF, Brown CD, Rader DJ, Voight BF. Multiplexed Targeted Resequencing Identifies Coding and Regulatory Variation Underlying Phenotypic Extremes of High-Density Lipoprotein Cholesterol in Humans. Circulation. Genomic and Precision Medicine. 11: e002070. PMID 29987113 DOI: 10.1161/CIRCGEN.117.002070  0.324
2018 Gusarova V, O'Dushlaine C, Teslovich TM, Benotti PN, Mirshahi T, Gottesman O, Van Hout CV, Murray MF, Mahajan A, Nielsen JB, Fritsche L, Wulff AB, Gudbjartsson DF, Sjögren M, Emdin CA, ... ... Rader DJ, et al. Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes. Nature Communications. 9: 2252. PMID 29899519 DOI: 10.1038/S41467-018-04611-Z  0.326
2018 Pirro M, Ricciuti B, Rader DJ, Catapano AL, Sahebkar A, Banach M. High density lipoprotein cholesterol and cancer: Marker or causative? Progress in Lipid Research. PMID 29879431 DOI: 10.1016/J.Plipres.2018.06.001  0.391
2018 Dos Santos Seckler H, Fornelli L, Mutharasan RK, Thaxton CS, Fellers RT, Daviglus M, Sniderman A, Rader D, Kelleher NL, Lloyd-Jones DM, Compton PD, Wilkins JT. A Targeted, Differential Top-Down Proteomic Methodology for Comparison of ApoA-I Proteoforms in Individuals with High and Low HDL Efflux Capacity. Journal of Proteome Research. PMID 29649363 DOI: 10.1021/Acs.Jproteome.8B00100  0.416
2018 Abul-Husn NS, Cheng X, Li AH, Xin Y, Schurmann C, Stevis P, Liu Y, Kozlitina J, Stender S, Wood GC, Stepanchick AN, Still MD, McCarthy S, O'Dushlaine C, Packer JS, ... ... Rader DJ, et al. A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease. The New England Journal of Medicine. 378: 1096-1106. PMID 29562163 DOI: 10.1056/Nejmoa1712191  0.312
2018 Olshan DS, Rader DJ. Angiopoietin-like protein 4: A therapeutic target for triglycerides and coronary disease? Journal of Clinical Lipidology. PMID 29548670 DOI: 10.1016/J.Jacl.2018.01.012  0.411
2018 Toth PP, Dwyer JP, Cannon CP, Colhoun HM, Rader DJ, Upadhyay A, Louie MJ, Koren A, Letierce A, Mandel J, Banach M. Efficacy and safety of lipid lowering by alirocumab in chronic kidney disease. Kidney International. PMID 29526502 DOI: 10.1016/J.Kint.2017.12.011  0.358
2018 Ajufo E, Rader DJ. New Therapeutic Approaches for Familial Hypercholesterolemia. Annual Review of Medicine. 69: 113-131. PMID 29414257 DOI: 10.1146/Annurev-Med-051215-030943  0.403
2018 Tsimikas S, Fazio S, Ferdinand KC, Ginsberg HN, Koschinsky ML, Marcovina SM, Moriarty PM, Rader DJ, Remaley AT, Reyes-Soffer G, Santos RD, Thanassoulis G, Witztum JL, Danthi S, Olive M, et al. NHLBI Working Group Recommendations to Reduce Lipoprotein(a)-Mediated Risk of Cardiovascular Disease and Aortic Stenosis. Journal of the American College of Cardiology. 71: 177-192. PMID 29325642 DOI: 10.1016/J.Jacc.2017.11.014  0.311
2018 Amengual J, Guo L, Strong A, Madrigal-Matute J, Wang H, Kaushik S, Brodsky JL, Rader DJ, Cuervo AM, Fisher EA. Autophagy Is Required for Sortilin-Mediated Degradation of Apolipoprotein B100. Circulation Research. PMID 29301854 DOI: 10.1161/Circresaha.117.311240  0.445
2018 Xu YX, Redon V, Yu H, Querbes W, Pirruccello J, Liebow A, Deik A, Trindade K, Wang X, Musunuru K, Clish CB, Cowan C, Fizgerald K, Rader D, Kathiresan S. Role of angiopoietin-like 3 (ANGPTL3) in regulating plasma level of low-density lipoprotein cholesterol. Atherosclerosis. 268: 196-206. PMID 29183623 DOI: 10.1016/J.Atherosclerosis.2017.08.031  0.45
2018 Johnston J, Angyal A, Bauer R, Rader D, Shoulders C, Francis S, Kiss-Toth E. 123 Myeloid TRIB1 controls experimental atherosclerosis Heart. 104. DOI: 10.1136/Heartjnl-2018-Bcs.122  0.34
2018 Cipollari E, Szapary HJ, Picataggi A, Billheimer JT, Shaw LM, Kaddurah-Daouk RF, Rader DJ, Kling MA, Lyssenko NN. P2-261: Apolipoprotein J/Clusterin Is The Primary Determinant Of The Cholesterol Efflux Capacity Of Cerebrospinal Fluid Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.950  0.343
2018 Javaheri A, Novak E, Lavine K, Rader D, Starling R, Chandraker A, Baran D, Heeger P. Pre-transplant Macrophage Cholesterol Efflux Capacity is Associated With Angiographic Cardiac Allograft Vasculopathy in a Multi-center Observational Study The Journal of Heart and Lung Transplantation. 37: S35-S36. DOI: 10.1016/J.Healun.2018.01.068  0.314
2017 Vitali C, Khetarpal SA, Rader DJ. HDL Cholesterol Metabolism and the Risk of CHD: New Insights from Human Genetics. Current Cardiology Reports. 19: 132. PMID 29103089 DOI: 10.1007/S11886-017-0940-0  0.451
2017 Wang X, Raghavan A, Peters DT, Pashos EE, Rader DJ, Musunuru K. Interrogation of the Atherosclerosis-Associated SORT1 (Sortilin 1) Locus With Primary Human Hepatocytes, Induced Pluripotent Stem Cell-Hepatocytes, and Locus-Humanized Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 29097363 DOI: 10.1161/Atvbaha.117.310103  0.38
2017 Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C, Alam D, Alves AC, Amouyel P, Di Angelantonio E, Arveiler D, Assimes TL, Auer PL, ... ... Rader DJ, et al. Exome-wide association study of plasma lipids in >300,000 individuals. Nature Genetics. PMID 29083408 DOI: 10.1038/Ng.3977  0.479
2017 Quinn WJ, Wan M, Shewale SV, Gelfer R, Rader DJ, Birnbaum MJ, Titchenell PM. mTORC1 stimulates phosphatidylcholine synthesis to promote triglyceride secretion. The Journal of Clinical Investigation. PMID 29035283 DOI: 10.1172/Jci96036  0.33
2017 Tall AR, Rader DJ. The Trials and Tribulations of CETP Inhibitors. Circulation Research. PMID 29018035 DOI: 10.1161/Circresaha.117.311978  0.404
2017 Kim HI, Raffler J, Lu W, Lee JJ, Abbey D, Saleheen D, Rabinowitz JD, Bennett MJ, Hand NJ, Brown C, Rader DJ. Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport. American Journal of Human Genetics. PMID 28942964 DOI: 10.1016/J.Ajhg.2017.08.008  0.346
2017 van den Boogert MAW, Rader DJ, Holleboom AG. New insights into the role of glycosylation in lipoprotein metabolism. Current Opinion in Lipidology. PMID 28922188 DOI: 10.1097/Mol.0000000000000461  0.326
2017 Dron JS, Wang J, Low-Kam C, Khetarpal SA, Robinson JF, McIntyre AD, Ban MR, Cao H, Rhainds D, Dubé MP, Rader DJ, Lettre G, Tardif JC, Hegele RA. Polygenic determinants in extremes of high-density lipoprotein cholesterol. Journal of Lipid Research. PMID 28870971 DOI: 10.1194/Jlr.M079822  0.437
2017 Zhao W, Rasheed A, Tikkanen E, Lee JJ, Butterworth AS, Howson JMM, Assimes TL, Chowdhury R, Orho-Melander M, Damrauer S, Small A, Asma S, Imamura M, Yamauch T, Chambers JC, ... ... Rader DJ, et al. Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. Nature Genetics. PMID 28869590 DOI: 10.1038/Ng.3943  0.347
2017 Koekemoer AL, Codd V, Masca NGD, Nelson CP, Musameh MD, Kaess BM, Hengstenberg C, Rader DJ, Samani NJ. Large-Scale Analysis of Determinants, Stability, and Heritability of High-Density Lipoprotein Cholesterol Efflux Capacity. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 28860221 DOI: 10.1161/Atvbaha.117.309201  0.346
2017 Koekemoer AL, Codd V, Masca NGD, Nelson CP, Musameh MD, Kaess BM, Hengstenberg C, Rader DJ, Samani NJ. Large-Scale Analysis of Determinants, Stability, and Heritability of High-Density Lipoprotein Cholesterol Efflux Capacity. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 28860221 DOI: 10.1161/Atvbaha.117.309201  0.346
2017 Bajaj A, Damrauer SM, Anderson AH, Xie D, Budoff MJ, Go AS, He J, Lash JP, Ojo A, Post WS, Rahman M, Reilly MP, Saleheen D, Townsend RR, Chen J, ... Rader DJ, et al. Lipoprotein(a) and Risk of Myocardial Infarction and Death in Chronic Kidney Disease: Findings From the CRIC Study (Chronic Renal Insufficiency Cohort). Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 28838919 DOI: 10.1161/Atvbaha.117.309920  0.304
2017 Hancock-Cerutti W, Lhomme M, Dauteuille C, Lecocq S, Chapman MJ, Rader DJ, Kontush A, Cuchel M. Paradoxical coronary artery disease in humans with hyperalphalipoproteinemia is associated with distinct differences in the high-density lipoprotein phosphosphingolipidome. Journal of Clinical Lipidology. PMID 28826666 DOI: 10.1016/J.Jacl.2017.06.018  0.444
2017 Khetarpal SA, Zeng X, Millar JS, Vitali C, Somasundara AVH, Zanoni P, Landro JA, Barucci N, Zavadoski WJ, Sun Z, de Haard H, Toth IV, Peloso GM, Natarajan P, Cuchel M, ... ... Rader DJ, et al. A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels. Nature Medicine. PMID 28825717 DOI: 10.1038/Nm.4390  0.427
2017 Thomas T, Zhou H, Karmally W, Ramakrishnan R, Holleran S, Liu Y, Jumes P, Wagner JA, Hubbard B, Previs SF, Roddy T, Johnson-Levonas AO, Gutstein DE, Marcovina SM, Rader DJ, et al. CETP (Cholesteryl Ester Transfer Protein) Inhibition With Anacetrapib Decreases Production of Lipoprotein(a) in Mildly Hypercholesterolemic Subjects. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 28729361 DOI: 10.1161/Atvbaha.117.309549  0.365
2017 Blom DJ, Averna MR, Meagher EA, du Toit Theron H, Sirtori CR, Hegele RA, Shah PK, Gaudet D, Stefanutti C, Vigna GB, Larrey D, Bloedon LT, Foulds P, Rader DJ, Cuchel M. Long-Term Efficacy and Safety of the Microsomal Triglyceride Transfer Protein Inhibitor Lomitapide in Patients With Homozygous Familial Hypercholesterolemia. Circulation. 136: 332-335. PMID 28716835 DOI: 10.1161/Circulationaha.117.028208  0.403
2017 Tuteja S, Wang L, Dunbar RL, Chen J, DerOhannessian S, Marcovina SM, Elam M, Lader E, Rader DJ. Genetic coding variants in the niacin receptor, hydroxyl-carboxylic acid receptor 2, and response to niacin therapy. Pharmacogenetics and Genomics. PMID 28628560 DOI: 10.1097/Fpc.0000000000000289  0.31
2017 Dewey FE, Gusarova V, Dunbar RL, O'Dushlaine C, Schurmann C, Gottesman O, McCarthy S, Van Hout CV, Bruse S, Dansky HM, Leader JB, Murray MF, Ritchie MD, Kirchner HL, Habegger L, ... ... Rader DJ, et al. Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease. The New England Journal of Medicine. PMID 28538136 DOI: 10.1056/Nejmoa1612790  0.493
2017 Howson JMM, Zhao W, Barnes DR, Ho WK, Young R, Paul DS, Waite LL, Freitag DF, Fauman EB, Salfati EL, Sun BB, Eicher JD, Johnson AD, Sheu WHH, Nielsen SF, ... ... Rader DJ, et al. Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms. Nature Genetics. PMID 28530674 DOI: 10.1038/Ng.3874  0.344
2017 Liu Y, Conlon DM, Bi X, Slovik KJ, Shi J, Edelstein HI, Millar JS, Javaheri A, Cuchel M, Pashos EE, Iqbal J, Hussain MM, Hegele RA, Yang W, Duncan SA, ... Rader DJ, et al. Lack of MTTP Activity in Pluripotent Stem Cell-Derived Hepatocytes and Cardiomyocytes Abolishes apoB Secretion and Increases Cell Stress. Cell Reports. 19: 1456-1466. PMID 28514664 DOI: 10.1016/J.Celrep.2017.04.064  0.355
2017 Lincoff AM, Nicholls SJ, Riesmeyer JS, Barter PJ, Brewer HB, Fox KAA, Gibson CM, Granger C, Menon V, Montalescot G, Rader D, Tall AR, McErlean E, Wolski K, Ruotolo G, et al. Evacetrapib and Cardiovascular Outcomes in High-Risk Vascular Disease. The New England Journal of Medicine. 376: 1933-1942. PMID 28514624 DOI: 10.1056/Nejmoa1609581  0.441
2017 Nomura A, Won HH, Khera AV, Takeuchi F, Ito K, McCarthy S, Emdin CA, Klarin D, Natarajan P, Zekavat SM, Gupta N, Peloso GM, Borecki IB, Teslovich TM, Asselta R, ... ... Rader DJ, et al. Protein Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease. Circulation Research. PMID 28506971 DOI: 10.1161/Circresaha.117.311145  0.446
2017 Khera AV, Demler O, Adelman SJ, Collins HL, Glynn RJ, Ridker PM, Rader DJ, Mora S. Cholesterol Efflux Capacity, HDL Particle Number, and Incident Cardiovascular Events. An Analysis from the JUPITER Trial (Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin). Circulation. PMID 28450350 DOI: 10.1161/Circulationaha.116.025678  0.44
2017 Döring Y, Noels H, van der Vorst EPC, Neideck C, Egea V, Drechsler M, Mandl M, Pawig LB, Jansen Y, Schröder K, Bidzhekov K, Megens RTA, Theelen W, Klinkhammer BM, Boor P, ... ... Rader DJ, et al. Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity: Evidence from Mouse and Human Studies. Circulation. PMID 28450349 DOI: 10.1161/Circulationaha.117.027646  0.362
2017 Saleheen D, Haycock PC, Zhao W, Rasheed A, Taleb A, Imran A, Abbas S, Majeed F, Akhtar S, Qamar N, Zaman KS, Yaqoob Z, Saghir T, Rizvi SN, Memon A, ... ... Rader DJ, et al. Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease: a mendelian randomisation analysis. The Lancet. Diabetes & Endocrinology. PMID 28408323 DOI: 10.1016/S2213-8587(17)30088-8  0.357
2017 Saleheen D, Natarajan P, Armean IM, Zhao W, Rasheed A, Khetarpal SA, Won HH, Karczewski KJ, O'Donnell-Luria AH, Samocha KE, Weisburd B, Gupta N, Zaidi M, Samuel M, Imran A, ... ... Rader DJ, et al. Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity. Nature. 544: 235-239. PMID 28406212 DOI: 10.1038/Nature22034  0.359
2017 Pashos EE, Park Y, Wang X, Raghavan A, Yang W, Abbey D, Peters DT, Arbelaez J, Hernandez M, Kuperwasser N, Li W, Lian Z, Liu Y, Lv W, Lytle-Gabbin SL, ... ... Rader DJ, et al. Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci. Cell Stem Cell. 20: 558-570.e10. PMID 28388432 DOI: 10.1016/J.Stem.2017.03.017  0.327
2017 Cayo MA, Mallanna SK, Di Furio F, Jing R, Tolliver LB, Bures M, Urick A, Noto FK, Pashos EE, Greseth MD, Czarnecki M, Traktman P, Yang W, Morrisey EE, Grompe M, ... Rader DJ, et al. A Drug Screen using Human iPSC-Derived Hepatocyte-like Cells Reveals Cardiac Glycosides as a Potential Treatment for Hypercholesterolemia. Cell Stem Cell. 20: 478-489.e5. PMID 28388428 DOI: 10.1016/J.Stem.2017.01.011  0.333
2017 Stitziel NO, Khera AV, Wang X, Bierhals AJ, Vourakis AC, Sperry AE, Natarajan P, Klarin D, Emdin CA, Zekavat SM, Nomura A, Erdmann J, Schunkert H, Samani NJ, Kraus WE, ... ... Rader DJ, et al. ANGPTL3 Deficiency and Protection Against Coronary Artery Disease. Journal of the American College of Cardiology. PMID 28385496 DOI: 10.1016/J.Jacc.2017.02.030  0.346
2017 Bi X, Pashos EE, Cuchel M, Lyssenko NN, Hernandez M, Picataggi A, McParland J, Yang W, Liu Y, Yan R, Yu C, DerOhannessian SL, Phillips MC, Morrisey EE, Duncan SA, ... Rader DJ, et al. ATP-Binding Cassette Transporter A1 Deficiency in Human Induced Pluripotent Stem Cell-Derived Hepatocytes Abrogates HDL Biogenesis and Enhances Triglyceride Secretion. Ebiomedicine. PMID 28330813 DOI: 10.1016/J.Ebiom.2017.03.018  0.427
2017 Greig JA, Limberis MP, Bell P, Chen SJ, Calcedo R, Rader DJ, Wilson JM. Non-Clinical Study Examining AAV8.TBG.hLDLR Vector-Associated Toxicity in Chow-Fed Wild-Type and LDLR(+/-) Rhesus Macaques. Human Gene Therapy. Clinical Development. 28: 39-50. PMID 28319449 DOI: 10.1089/Humc.2017.014  0.335
2017 Millar JS, Lassman ME, Thomas T, Ramakrishnan R, Jumes P, Dunbar RL, deGoma EM, Baer AL, Karmally W, Donovan DS, Rafeek H, Wagner JA, Holleran S, Obunike J, Liu Y, ... ... Rader DJ, et al. Effects of CETP Inhibition with Anacetrapib on Metabolism of VLDL TG and Plasma Apolipoproteins C-II, C-III, and E. Journal of Lipid Research. PMID 28314859 DOI: 10.1194/Jlr.M074880  0.375
2017 Khera AV, Won HH, Peloso GM, O'Dushlaine C, Liu D, Stitziel NO, Natarajan P, Nomura A, Emdin CA, Gupta N, Borecki IB, Asselta R, Duga S, Merlini PA, Correa A, ... ... Rader DJ, et al. Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease. Jama. 317: 937-946. PMID 28267856 DOI: 10.1001/Jama.2017.0972  0.411
2017 Natarajan P, Young R, Stitziel NO, Padmanabhan S, Baber U, Mehran R, Sartori S, Fuster V, Reilly DF, Butterworth AS, Rader DJ, Ford I, Sattar N, Kathiresan S. Polygenic Risk Score Identifies Subgroup with Higher Burden of Atherosclerosis and Greater Relative Benefit from Statin Therapy in the Primary Prevention Setting. Circulation. PMID 28223407 DOI: 10.1161/Circulationaha.116.024436  0.349
2017 Webb TR, Erdmann J, Stirrups KE, Stitziel NO, Masca NG, Jansen H, Kanoni S, Nelson CP, Ferrario PG, König IR, Eicher JD, Johnson AD, Hamby SE, Betsholtz C, Ruusalepp A, ... ... Rader DJ, et al. Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease. Journal of the American College of Cardiology. 69: 823-836. PMID 28209224 DOI: 10.1016/J.Jacc.2016.11.056  0.324
2017 Rader DJ, Bajaj A, Khetarpal SA. Deep Apolipoprotein Proteomics to Uncover Mechanisms of Coronary Disease Risk. Journal of the American College of Cardiology. 69: 801-804. PMID 28209221 DOI: 10.1016/J.Jacc.2016.11.066  0.319
2017 Ueda M, Dunbar RL, Wolska A, Sikora TU, Escobar MD, Seliktar N, deGoma E, DerOhannessian S, Morrell L, McIntyre AD, Burke F, Sviridov D, Amar M, Shamburek RD, Freeman L, ... ... Rader DJ, et al. A Novel APOC2 Missense Mutation Causing Apolipoprotein C-II Deficiency with Severe Triglyceridemia and Pancreatitis. The Journal of Clinical Endocrinology and Metabolism. PMID 28201738 DOI: 10.1210/Jc.2016-3903  0.332
2017 Rader DJ. Mediterranean Approach to Improving High-Density Lipoprotein Function. Circulation. 135: 644-647. PMID 28193798 DOI: 10.1161/Circulationaha.117.026278  0.451
2017 Chhatriwalla AK, Rader DJ. Intracoronary Imaging, Reverse Cholesterol Transport, and Transcriptomics: Precision Medicine in CAD? Journal of the American College of Cardiology. 69: 641-643. PMID 28183507 DOI: 10.1016/J.Jacc.2016.12.003  0.327
2017 Cuchel M, Raper AC, Conlon DM, Pryma DA, Freifelder RH, Poria R, Cromley D, Li X, Dunbar RL, French B, Qu L, Farver W, Su CC, Lund-Katz S, Baer A, ... ... Rader DJ, et al. A Novel Approach to Measuring Macrophage-specific Reverse Cholesterol Transport in Vivo in Humans. Journal of Lipid Research. PMID 28167703 DOI: 10.1194/Jlr.M075226  0.391
2017 Kuwano T, Bi X, Cipollari E, Yasuda T, Lagor WR, Szapary HJ, Tohyama J, Millar JS, Billheimer JT, Lyssenko NN, Rader DJ. Overexpression and deletion of phospholipid transfer protein reduce HDL mass and cholesterol efflux capacity but not macrophage reverse cholesterol transport. Journal of Lipid Research. PMID 28137768 DOI: 10.1194/Jlr.M074625  0.45
2017 Johnston JM, Angyal A, Hadadi E, Hamby SE, Bauer R, Ilyas Z, Szili D, Ariaans M, Wilson HL, Krauss RM, Rader DJ, Goodall AH, Francis SE, Kiss-Toth E. 157 Myeloid expression of trib1 regulates the polarisation state of tissue resident macrophages that has consequences on plasma lipid and metabolic homeostasis Heart. 103: A113.2-A113. DOI: 10.1136/Heartjnl-2017-311726.156  0.399
2017 Penson P, Long L, Howard G, Howard V, Jones, Martin S, Mikhailidis D, Muntner P, Rizzo M, Rader D, Safford M, Sahebkar A, Toth P, Banach M. Associations between cardiovascular disease, cancer and very low HDL cholesterol in the REasons for Geographical And Racial Differences in Stroke (REGARDS) study. European Heart Journal. 38. DOI: 10.1093/Eurheartj/Ehx504.3104  0.388
2016 Emdin CA, Khera AV, Natarajan P, Klarin D, Baber U, Mehran R, Rader DJ, Fuster V, Kathiresan S. Evaluation of the Pooled Cohort Equations for Prediction of Cardiovascular Risk in a Contemporary Prospective Cohort. The American Journal of Cardiology. PMID 28061997 DOI: 10.1016/J.Amjcard.2016.11.042  0.329
2016 Emdin CA, Khera AV, Natarajan P, Klarin D, Won HH, Peloso GM, Stitziel NO, Nomura A, Zekavat SM, Bick AG, Gupta N, Asselta R, Duga S, Merlini PA, Correa A, ... ... Rader DJ, et al. Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels. Journal of the American College of Cardiology. 68: 2761-2772. PMID 28007139 DOI: 10.1016/J.Jacc.2016.10.033  0.406
2016 Khera AV, Emdin CA, Drake I, Natarajan P, Bick AG, Cook NR, Chasman DI, Baber U, Mehran R, Rader DJ, Fuster V, Boerwinkle E, Melander O, Orho-Melander M, Ridker PM, et al. Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease. The New England Journal of Medicine. PMID 27959714 DOI: 10.1056/Nejmoa1605086  0.337
2016 Natarajan P, Bis JC, Bielak LF, Cox AJ, Dörr M, Feitosa MF, Franceschini N, Guo X, Hwang SJ, Isaacs A, Jhun MA, Kavousi M, Li-Gao R, Lyytikäinen LP, Marioni RE, ... ... Rader DJ, et al. Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis. Circulation. Cardiovascular Genetics. PMID 27872105 DOI: 10.1161/Circgenetics.116.001572  0.36
2016 Small AM, Mehta NN, Rader DJ. The Role of Emerging Biomarkers in Unraveling the Complex Biology Underlying Associations between HDL Cholesterol and Cardiovascular Diseases. Clinical Chemistry. PMID 27815309 DOI: 10.1373/Clinchem.2016.267922  0.361
2016 Jacoby DS, Rader DJ. Improving cardiovascular outcomes by intensifying low density lipoprotein lowering therapy in high-risk patients. European Heart Journal. PMID 27742811 DOI: 10.1093/Eurheartj/Ehw447  0.41
2016 van Capelleveen JC, Kastelein JJ, Zwinderman AH, van Deventer SJ, Collins HL, Adelman SJ, Round P, Ford J, Rader DJ, Hovingh GK. Effects of the cholesteryl ester transfer protein inhibitor, TA-8995, on cholesterol efflux capacity and high-density lipoprotein particle subclasses. Journal of Clinical Lipidology. 10: 1137-1144.e3. PMID 27678430 DOI: 10.1016/J.Jacl.2016.06.006  0.421
2016 Quach D, Vitali C, La FM, Xiao AX, Millar JS, Tang C, Rader DJ, Phillips MC, Lyssenko NN. Cell lipid metabolism modulators 2-bromopalmitate, D609, monensin, U18666A and probucol shift discoidal HDL formation to the smaller-sized particles: implications for the mechanism of HDL assembly. Biochimica Et Biophysica Acta. PMID 27671775 DOI: 10.1016/J.Bbalip.2016.09.017  0.394
2016 Joshi AA, Lerman JB, Aberra TM, Afshar M, Teague HL, Rodante JA, Krishnamoorthy P, Ng Q, Aridi TZ, Salahuddin T, Natarajan B, Lockshin BN, Ahlman MA, Chen MY, Rader DJ, et al. GlycA Is a Novel Biomarker of Inflammation and Subclinical Cardiovascular Disease in Psoriasis. Circulation Research. PMID 27654120 DOI: 10.1161/Circresaha.116.309637  0.304
2016 Ginsberg HN, Rader DJ, Raal FJ, Guyton JR, Baccara-Dinet MT, Lorenzato C, Pordy R, Stroes E. Efficacy and Safety of Alirocumab in Patients with Heterozygous Familial Hypercholesterolemia and LDL-C of 160 mg/dl or Higher. Cardiovascular Drugs and Therapy / Sponsored by the International Society of Cardiovascular Pharmacotherapy. PMID 27618825 DOI: 10.1007/S10557-016-6685-Y  0.39
2016 Beheshtian A, Shitole SG, Segal AZ, Leifer D, Tracy RP, Rader DJ, Devereux RB, Kizer JR. Lipoprotein (a) level, apolipoprotein (a) size, and risk of unexplained ischemic stroke in young and middle-aged adults. Atherosclerosis. 253: 47-53. PMID 27575936 DOI: 10.1016/J.Atherosclerosis.2016.08.013  0.303
2016 Mansouri B, Kivelevitch D, Natarajan B, Joshi AA, Ryan C, Benjegerdes K, Schussler JM, Rader DJ, Reilly MP, Menter A, Mehta NN. Comparison of Coronary Artery Calcium Scores Between Patients With Psoriasis and Type 2 Diabetes. Jama Dermatology. PMID 27556410 DOI: 10.1001/Jamadermatol.2016.2907  0.314
2016 Khetarpal SA, Schjoldager KT, Christoffersen C, Raghavan A, Edmondson AC, Reutter HM, Ahmed B, Ouazzani R, Peloso GM, Vitali C, Zhao W, Somasundara AV, Millar JS, Park Y, Fernando G, ... ... Rader DJ, et al. Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents. Cell Metabolism. 24: 234-245. PMID 27508872 DOI: 10.1016/J.Cmet.2016.07.012  0.695
2016 Javaheri A, Molina M, Zamani P, Rodrigues A, Novak E, Chambers S, Stutman P, Maslanek W, Williams M, Lilly SM, Heeger P, Sayegh MH, Chandraker A, Briscoe DM, Daly KP, ... ... Rader DJ, et al. Cholesterol efflux capacity of high-density lipoprotein correlates with survival and allograft vasculopathy in cardiac transplant recipients. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society For Heart Transplantation. PMID 27498384 DOI: 10.1016/J.Healun.2016.06.022  0.38
2016 Saleheen D, Rader DJ, Voight BF. Disentangling the Causal Association of Plasma Lipid Traits and Type 2 Diabetes Using Human Genetics. Jama Cardiology. PMID 27487162 DOI: 10.1001/Jamacardio.2016.2298  0.327
2016 Khetarpal SA, Qamar A, Millar JS, Rader DJ. Targeting ApoC-III to Reduce Coronary Disease Risk. Current Atherosclerosis Reports. 18: 54. PMID 27443326 DOI: 10.1007/S11883-016-0609-Y  0.392
2016 Hsieh J, Koseki M, Molusky MM, Yakushiji E, Ichi I, Westerterp M, Iqbal J, Chan RB, Abramowicz S, Tascau L, Takiguchi S, Yamashita S, Welch CL, Di Paolo G, Hussain MM, ... ... Rader DJ, et al. TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis. Nature. PMID 27383786 DOI: 10.1038/Nature18628  0.412
2016 Nioi P, Sigurdsson A, Thorleifsson G, Helgason H, Agustsdottir AB, Norddahl GL, Helgadottir A, Magnusdottir A, Jonasdottir A, Gretarsdottir S, Jonsdottir I, Steinthorsdottir V, Rafnar T, Swinkels DW, Galesloot TE, ... ... Rader DJ, et al. Variant ASGR1 Associated with a Reduced Risk of Coronary Artery Disease. The New England Journal of Medicine. PMID 27192541 DOI: 10.1056/Nejmoa1508419  0.437
2016 Chen Y, Dong J, Chen X, Jiang H, Bakillah A, Zhang X, Li Z, Yin J, Liang D, Zou Y, Hussain M, Cuchel M, Rader D, Chen H, Ge J, et al. Human serum preβ1-high density lipoprotein levels are independently and negatively associated with coronary artery diseases. Nutrition & Metabolism. 13: 36. PMID 27190545 DOI: 10.1186/S12986-016-0093-Y  0.425
2016 Patel AP, Peloso GM, Pirruccello JP, Johansen CT, Dubé JB, Larach DB, Ban MR, Dallinge-Thie GM, Gupta N, Boehnke M, Abecasis GR, Kastelein JJ, Hovingh GK, Hegele RA, Rader DJ, et al. Targeted exonic sequencing of GWAS loci in the high extremes of the plasma lipids distribution. Atherosclerosis. 250: 63-68. PMID 27182959 DOI: 10.1016/J.Atherosclerosis.2016.04.011  0.334
2016 Khera AV, Won HH, Peloso GM, Lawson KS, Bartz TM, Deng X, van Leeuwen EM, Natarajan P, Emdin CA, Bick AG, Morrison AC, Brody JA, Gupta N, Nomura A, Kessler T, ... ... Rader DJ, et al. Diagnostic Yield of Sequencing Familial Hypercholesterolemia Genes in Patients with Severe Hypercholesterolemia. Journal of the American College of Cardiology. PMID 27050191 DOI: 10.1016/J.Jacc.2016.03.520  0.425
2016 Ajufo E, Rader DJ. Recent advances in the pharmacological management of hypercholesterolaemia. The Lancet. Diabetes & Endocrinology. PMID 27012540 DOI: 10.1016/S2213-8587(16)00074-7  0.429
2016 Bauer RC, Khetarpal SA, Hand NJ, Rader DJ. Therapeutic Targets of Triglyceride Metabolism as Informed by Human Genetics. Trends in Molecular Medicine. PMID 26988439 DOI: 10.1016/J.Molmed.2016.02.005  0.414
2016 Reyes-Soffer G, Millar JS, Ngai C, Jumes P, Coromilas E, Asztalos B, Johnson-Levonas AO, Wagner JA, Donovan DS, Karmally W, Ramakrishnan R, Holleran S, Thomas T, Dunbar RL, deGoma EM, ... ... Rader DJ, et al. Cholesteryl Ester Transfer Protein Inhibition With Anacetrapib Increases Fractional Clearance Rates of High-Density Lipoprotein Apolipoprotein A-I and Plasma Cholesteryl Ester Transfer Protein. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 26966279 DOI: 10.1161/Atvbaha.115.306680  0.404
2016 Zanoni P, Khetarpal SA, Larach DB, Hancock-Cerutti WF, Millar JS, Cuchel M, DerOhannessian S, Kontush A, Surendran P, Saleheen D, Trompet S, Jukema JW, De Craen A, Deloukas P, Sattar N, ... ... Rader DJ, et al. Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease. Science (New York, N.Y.). 351: 1166-71. PMID 26965621 DOI: 10.1126/science.aad3517  0.385
2016 Goettsch C, Hutcheson JD, Aikawa M, Iwata H, Pham T, Nykjaer A, Kjolby M, Rogers M, Michel T, Shibasaki M, Hagita S, Kramann R, Rader DJ, Libby P, Singh SA, et al. Sortilin mediates vascular calcification via its recruitment into extracellular vesicles. The Journal of Clinical Investigation. PMID 26950419 DOI: 10.1172/Jci80851  0.317
2016 Nurnberg ST, Zhang H, Hand NJ, Bauer RC, Saleheen D, Reilly MP, Rader DJ. From Loci to Biology: Functional Genomics of Genome-Wide Association for Coronary Disease. Circulation Research. 118: 586-606. PMID 26892960 DOI: 10.1161/Circresaha.115.306464  0.364
2016 Rader DJ. New Therapeutic Approaches to the Treatment of Dyslipidemia. Cell Metabolism. PMID 26853751 DOI: 10.1016/J.Cmet.2016.01.005  0.484
2016 Keenan T, Zhao W, Rasheed A, Ho WK, Malik R, Felix JF, Young R, Shah N, Samuel M, Sheikh N, Mucksavage ML, Shah O, Li J, Morley M, Laser A, ... ... Rader DJ, et al. Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study. Journal of the American College of Cardiology. 67: 407-16. PMID 26821629 DOI: 10.1016/J.Jacc.2015.10.086  0.34
2016 Ibrahim S, Somanathan S, Billheimer J, Wilson JM, Rader DJ. Stable Liver-specific Expression of Human IDOL in Humanized Mice Raises Plasma Cholesterol. Cardiovascular Research. PMID 26786161 DOI: 10.1093/Cvr/Cvw010  0.488
2016 Khera AV, Demler OV, Adelman SJ, Collins H, Glynn R, Ridker P, Rader D, Mora S. CHOLESTEROL EFFLUX CAPACITY, HDL-PARTICLE NUMBER, AND INCIDENT CARDIOVASCULAR EVENTS: RESULTS FROM THE JUPITER TRIAL Journal of the American College of Cardiology. 67: 1851. DOI: 10.1016/S0735-1097(16)31852-6  0.362
2015 Winsvold BS, Nelson CP, Malik R, Gormley P, Anttila V, Vander Heiden J, Elliott KS, Jacobsen LM, Palta P, Amin N, de Vries B, Hämäläinen E, Freilinger T, Ikram MA, Kessler T, ... ... Rader DJ, et al. Genetic analysis for a shared biological basis between migraine and coronary artery disease. Neurology. Genetics. 1: e10. PMID 27066539 DOI: 10.1212/Nxg.0000000000000010  0.343
2015 Nicholls SJ, Lincoff AM, Barter PJ, Brewer HB, Fox KA, Gibson CM, Grainger C, Menon V, Montalescot G, Rader D, Tall AR, McErlean E, Riesmeyer J, Vangerow B, Ruotolo G, et al. Assessment of the clinical effects of cholesteryl ester transfer protein inhibition with evacetrapib in patients at high-risk for vascular outcomes: Rationale and design of the ACCELERATE trial. American Heart Journal. 170: 1061-9. PMID 26678626 DOI: 10.1016/J.Ahj.2015.09.007  0.422
2015 Herzog E, Pragst I, Waelchli M, Gille A, Schenk S, Mueller-Cohrs J, Diditchenko S, Zanoni P, Cuchel M, Seubert A, Rader DJ, Wright SD. Reconstituted high-density lipoprotein can elevate plasma alanine aminotransferase by transient depletion of hepatic cholesterol: role of the phospholipid component. Journal of Applied Toxicology : Jat. PMID 26651060 DOI: 10.1002/Jat.3264  0.462
2015 Nicholls SJ, Ruotolo G, Brewer HB, Kane JP, Wang MD, Krueger KA, Adelman SJ, Nissen SE, Rader DJ. Cholesterol Efflux Capacity and Pre-Beta-1 HDL Concentrations Are Increased in Dyslipidemic Patients Treated With Evacetrapib. Journal of the American College of Cardiology. 66: 2201-10. PMID 26564598 DOI: 10.1016/J.Jacc.2015.09.013  0.457
2015 Bauer RC, Yenilmez BO, Rader DJ. Tribbles-1: a novel regulator of hepatic lipid metabolism in humans. Biochemical Society Transactions. 43: 1079-84. PMID 26517927 DOI: 10.1042/Bst20150101  0.48
2015 Natarajan P, Kohli P, Baber U, Nguyen KD, Sartori S, Reilly DF, Mehran R, Muntendam P, Fuster V, Rader DJ, Kathiresan S. Association of APOC3 Loss-of-Function Mutations With Plasma Lipids and Subclinical Atherosclerosis: The Multi-Ethnic BioImage Study. Journal of the American College of Cardiology. 66: 2053-5. PMID 26516010 DOI: 10.1016/J.Jacc.2015.08.866  0.412
2015 Gidding SS, Ann Champagne M, de Ferranti SD, Defesche J, Ito MK, Knowles JW, McCrindle B, Raal F, Rader D, Santos RD, Lopes-Virella M, Watts GF, Wierzbicki AS. The Agenda for Familial Hypercholesterolemia: A Scientific Statement From the American Heart Association. Circulation. PMID 26510694 DOI: 10.1161/Cir.0000000000000297  0.433
2015 Lagor WR, Tong F, Jarrett KE, Lin W, Conlon DM, Smith M, Wang MY, Yenilmez BO, McCoy MG, Fields DW, O'Neill SM, Gupta R, Kumaravel A, Redon V, Ahima RS, ... ... Rader DJ, et al. Deletion of murine Arv1 results in a lean phenotype with increased energy expenditure. Nutrition & Diabetes. 5: e181. PMID 26479315 DOI: 10.1038/Nutd.2015.32  0.312
2015 Hegele RA, Gidding SS, Ginsberg HN, McPherson R, Raal FJ, Rader DJ, Robinson JG, Welty FK. Nonstatin Low-Density Lipoprotein-Lowering Therapy and Cardiovascular Risk Reduction-Statement From ATVB Council. Arteriosclerosis, Thrombosis, and Vascular Biology. 35: 2269-80. PMID 26376908 DOI: 10.1161/Atvbaha.115.306442  0.455
2015 Guo Y, Fan Y, Zhang J, Lomberk GA, Zhou Z, Sun L, Mathison AJ, Garcia-Barrio MT, Zhang J, Zeng L, Li L, Pennathur S, Willer CJ, Rader DJ, Urrutia R, et al. Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production. The Journal of Clinical Investigation. PMID 26368306 DOI: 10.1172/Jci79048  0.522
2015 Rader DJ. Lysosomal Acid Lipase Deficiency--A New Therapy for a Genetic Lipid Disease. The New England Journal of Medicine. 373: 1071-3. PMID 26352819 DOI: 10.1056/Nejme1509055  0.314
2015 Peloso GM, Rader DJ, Gabriel S, Kathiresan S, Daly MJ, Neale BM. Phenotypic extremes in rare variant study designs. European Journal of Human Genetics : Ejhg. PMID 26350511 DOI: 10.1038/Ejhg.2015.197  0.388
2015 Iqbal J, Walsh MT, Hammad SM, Cuchel M, Tarugi P, Hegele RA, Davidson NO, Rader DJ, Klein RL, Hussain MM. Microsomal triglyceride transfer protein transfers and determines plasma concentrations of ceramide and sphingomyelin, but not glycosylceramide. The Journal of Biological Chemistry. PMID 26350457 DOI: 10.1074/Jbc.M115.659110  0.377
2015 Bauer RC, Sasaki M, Cohen DM, Cui J, Smith MA, Yenilmez BO, Steger DJ, Rader DJ. Tribbles-1 regulates hepatic lipogenesis through posttranscriptional regulation of C/EBPα. The Journal of Clinical Investigation. PMID 26348894 DOI: 10.1172/Jci77095  0.427
2015 Nikpay M, Goel A, Won HH, Hall LM, Willenborg C, Kanoni S, Saleheen D, Kyriakou T, Nelson CP, Hopewell JC, Webb TR, Zeng L, Dehghan A, Alver M, Armasu SM, ... ... Rader DJ, et al. A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nature Genetics. 47: 1121-30. PMID 26343387 DOI: 10.1038/Ng.3396  0.393
2015 Wolf JH, Holmes MV, Fouraschen S, Keating BJ, Baker T, Emond J, Rader DJ, Shaked A, Olthoff KM. Serum lipid expression correlates with function and regeneration following living donor liver transplantation. Liver Transplantation : Official Publication of the American Association For the Study of Liver Diseases and the International Liver Transplantation Society. PMID 26202132 DOI: 10.1002/Lt.24220  0.371
2015 Siddiqi HK, Kiss D, Rader D. HDL-cholesterol and cardiovascular disease: Rethinking our approach Current Opinion in Cardiology. 30: 536-542. PMID 26192490 DOI: 10.1097/Hco.0000000000000211  0.394
2015 Khera AV, Qamar A, Murphy SA, Cannon CP, Sabatine MS, Rader DJ. On-Statin Resistin, Leptin, and Risk of Recurrent Coronary Events After Hospitalization for an Acute Coronary Syndrome (from the Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 Study). The American Journal of Cardiology. PMID 26119654 DOI: 10.1016/J.Amjcard.2015.05.038  0.321
2015 Khera AV, Millar JS, Ruotolo G, Wang MD, Rader DJ. Potent peroxisome proliferator-activated receptor-α agonist treatment increases cholesterol efflux capacity in humans with the metabolic syndrome. European Heart Journal. PMID 26112886 DOI: 10.1093/Eurheartj/Ehv291  0.435
2015 Qamar A, Khetarpal SA, Khera AV, Qasim A, Rader DJ, Reilly MP. Plasma apolipoprotein C-III levels, triglycerides, and coronary artery calcification in type 2 diabetics. Arteriosclerosis, Thrombosis, and Vascular Biology. 35: 1880-8. PMID 26069232 DOI: 10.1161/Atvbaha.115.305415  0.426
2015 Hovingh GK, Kastelein JJ, van Deventer SJ, Round P, Ford J, Saleheen D, Rader DJ, Brewer HB, Barter PJ. Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidaemia (TULIP): a randomised, double-blind, placebo-controlled phase 2 trial. Lancet (London, England). 386: 452-60. PMID 26047975 DOI: 10.1016/S0140-6736(15)60158-1  0.387
2015 Saleheen D, Scott R, Javad S, Zhao W, Rodrigues A, Picataggi A, Lukmanova D, Mucksavage ML, Luben R, Billheimer J, Kastelein JJ, Boekholdt SM, Khaw KT, Wareham N, Rader DJ. Association of HDL cholesterol efflux capacity with incident coronary heart disease events: a prospective case-control study. The Lancet. Diabetes & Endocrinology. 3: 507-13. PMID 26025389 DOI: 10.1016/S2213-8587(15)00126-6  0.442
2015 Millar JS, Reyes-Soffer G, Jumes P, Dunbar RL, deGoma EM, Baer AL, Karmally W, Donovan DS, Rafeek H, Pollan L, Tohyama J, Johnson-Levonas AO, Wagner JA, Holleran S, Obunike J, ... ... Rader DJ, et al. Anacetrapib lowers LDL by increasing ApoB clearance in mildly hypercholesterolemic subjects. The Journal of Clinical Investigation. 125: 2510-22. PMID 25961461 DOI: 10.1172/Jci80025  0.397
2015 Julius U, Milton M, Stoellner D, Rader D, Gordon B, Polk D, Waldmann E, Parhofer KG, Moriarty PM. Effects of lipoprotein apheresis on PCSK9 levels. Atherosclerosis. Supplements. 18: 180-6. PMID 25936324 DOI: 10.1016/J.Atherosclerosissup.2015.02.028  0.431
2015 Zhang H, Xue C, Shah R, Bermingham K, Hinkle CC, Li W, Rodrigues A, Tabita-Martinez J, Millar JS, Cuchel M, Pashos EE, Liu Y, Yan R, Yang W, Gosai SJ, ... ... Rader DJ, et al. Functional Analysis and Transcriptomic Profiling of iPSC-Derived Macrophages and Their Application in Modeling Mendelian Disease. Circulation Research. 117: 17-28. PMID 25904599 DOI: 10.1161/Circresaha.117.305860  0.307
2015 Stefanutti C, Blom DJ, Averna MR, Meagher EA, Theron Hd, Marais AD, Hegele RA, Sirtori CR, Shah PK, Gaudet D, Vigna GB, Sachais BS, Di Giacomo S, du Plessis AM, Bloedon LT, ... ... Rader DJ, et al. The lipid-lowering effects of lomitapide are unaffected by adjunctive apheresis in patients with homozygous familial hypercholesterolaemia - a post-hoc analysis of a Phase 3, single-arm, open-label trial. Atherosclerosis. 240: 408-14. PMID 25897792 DOI: 10.1016/J.Atherosclerosis.2015.03.014  0.42
2015 Agarwala AP, Rodrigues A, Risman M, McCoy M, Trindade K, Qu L, Cuchel M, Billheimer J, Rader DJ. High-Density Lipoprotein (HDL) Phospholipid Content and Cholesterol Efflux Capacity Are Reduced in Patients With Very High HDL Cholesterol and Coronary Disease. Arteriosclerosis, Thrombosis, and Vascular Biology. 35: 1515-9. PMID 25838421 DOI: 10.1161/Atvbaha.115.305504  0.493
2015 Rader DJ. Human genetics of atherothrombotic disease and its risk factors. Arteriosclerosis, Thrombosis, and Vascular Biology. 35: 741-7. PMID 25810293 DOI: 10.1161/Atvbaha.115.305492  0.423
2015 Bauer RC, Tohyama J, Cui J, Cheng L, Yang J, Zhang X, Ou K, Paschos GK, Zheng XL, Parmacek MS, Rader DJ, Reilly MP. Knockout of Adamts7, a novel coronary artery disease locus in humans, reduces atherosclerosis in mice. Circulation. 131: 1202-13. PMID 25712206 DOI: 10.1161/Circulationaha.114.012669  0.341
2015 Hovingh GK, Rader DJ, Hegele RA. HDL re-examined. Current Opinion in Lipidology. 26: 127-32. PMID 25692348 DOI: 10.1097/Mol.0000000000000161  0.437
2015 Goldberg RB, Rader D. The disappearing high density lipoprotein syndrome. Journal of Clinical Lipidology. 9: 91-2. PMID 25670365 DOI: 10.1016/J.Jacl.2014.12.011  0.352
2015 Luthi AJ, Lyssenko NN, Quach D, McMahon KM, Millar JS, Vickers KC, Rader DJ, Phillips MC, Mirkin CA, Thaxton CS. Robust passive and active efflux of cellular cholesterol to a designer functional mimic of high density lipoprotein. Journal of Lipid Research. 56: 972-85. PMID 25652088 DOI: 10.1194/Jlr.M054635  0.448
2015 Thormaehlen AS, Schuberth C, Won HH, Blattmann P, Joggerst-Thomalla B, Theiss S, Asselta R, Duga S, Merlini PA, Ardissino D, Lander ES, Gabriel S, Rader DJ, Peloso GM, Pepperkok R, et al. Systematic cell-based phenotyping of missense alleles empowers rare variant association studies: a case for LDLR and myocardial infarction. Plos Genetics. 11: e1004855. PMID 25647241 DOI: 10.1371/Journal.Pgen.1004855  0.484
2015 Stitziel NO, Peloso GM, Abifadel M, Cefalu AB, Fouchier S, Motazacker MM, Tada H, Larach DB, Awan Z, Haller JF, Pullinger CR, Varret M, Rabès JP, Noto D, Tarugi P, ... ... Rader DJ, et al. Exome sequencing in suspected monogenic dyslipidemias. Circulation. Cardiovascular Genetics. 8: 343-50. PMID 25632026 DOI: 10.1161/Circgenetics.114.000776  0.311
2015 Patel KM, Strong A, Tohyama J, Jin X, Morales CR, Billheimer J, Millar J, Kruth H, Rader DJ. Macrophage sortilin promotes LDL uptake, foam cell formation, and atherosclerosis. Circulation Research. 116: 789-96. PMID 25593281 DOI: 10.1161/Circresaha.116.305811  0.507
2015 Khetarpal SA, Rader DJ. Triglyceride-rich lipoproteins and coronary artery disease risk: new insights from human genetics. Arteriosclerosis, Thrombosis, and Vascular Biology. 35: e3-9. PMID 25573854 DOI: 10.1161/Atvbaha.114.305172  0.499
2015 Daugherty A, Tabas I, Rader DJ. Accelerating the pace of atherosclerosis research. Arteriosclerosis, Thrombosis, and Vascular Biology. 35: 11-2. PMID 25520521 DOI: 10.1161/Atvbaha.114.304833  0.415
2015 Do R, Stitziel NO, Won HH, Jørgensen AB, Duga S, Angelica Merlini P, Kiezun A, Farrall M, Goel A, Zuk O, Guella I, Asselta R, Lange LA, Peloso GM, Auer PL, ... ... Rader DJ, et al. Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction. Nature. 518: 102-6. PMID 25487149 DOI: 10.1038/Nature13917  0.426
2015 Khera AV, Qamar A, Reilly MP, Dunbar RL, Rader DJ. Effects of niacin, statin, and fenofibrate on circulating proprotein convertase subtilisin/kexin type 9 levels in patients with dyslipidemia. The American Journal of Cardiology. 115: 178-82. PMID 25432415 DOI: 10.1016/J.Amjcard.2014.10.018  0.373
2015 Christopher DM, Billheimer J, Marchadier D, Susztak K, Remaley A, Wilson J, Rader DJ. 9. AAV-Mediated Gene Transfer as a Therapeutic Approach for Familial LCAT Deficiency Molecular Therapy. 23: S4. DOI: 10.1016/S1525-0016(16)33613-9  0.416
2015 Qamar A, Khetarpal S, Khera A, Qasim A, Reilly M, Rader D. PLASMA APOC-III LEVELS, TRIGLYCERIDES, AND CORONARY ARTERY CALCIFICATION IN TYPE 2 DIABETICS Journal of the American College of Cardiology. 65: A1373. DOI: 10.1016/S0735-1097(15)61373-0  0.445
2015 O’Brien EC, DeGoma E, Moriarty P, Linton MF, Shapiro M, Duell B, Ballantyne C, Neal W, Ahmad Z, Duffy D, Hudgins L, Hemphill L, Underberg J, Watson K, Gidding S, ... ... Rader D, et al. INITIAL RESULTS FROM THE CASCADE-FH REGISTRY: CASCADE SCREENING FOR AWARENESS AND DETECTION OF FAMILIAL HYPERCHOLESTEROLEMIA Journal of the American College of Cardiology. 65: A1372. DOI: 10.1016/S0735-1097(15)61372-9  0.425
2015 Hancock-Cerutti W, Valentini S, Liu J, Billheimer J, Millar J, Rader D, Cuchel M. Cholesterol efflux capacity inversely correlates with HDL cholesterol fractional catabolic rate Atherosclerosis. 241: e106-e107. DOI: 10.1016/J.Atherosclerosis.2015.04.373  0.414
2015 Khetarpal S, Varshini A, Larach D, Tabita-Martinez J, McParland J, McCoy M, Rodrigues A, Kiss D, Zanoni P, Mucksavage M, Millar J, Cuchel M, Lund-Katz S, Phillips M, Kathiresan S, ... Rader D, et al. Coronary artery disease-protective A43T variant in APOC3 alters circulating ApoC-III levels in vivo Atherosclerosis. 241: e37. DOI: 10.1016/J.Atherosclerosis.2015.04.136  0.309
2015 Cuchel M, McParland J, Wang J, Hegele R, Rader D. Clinical and biochemical characteristics are varied in subjects with ABCA1 mutations Atherosclerosis. 241: e37. DOI: 10.1016/J.Atherosclerosis.2015.04.134  0.375
2015 Angyal A, Ilyas Z, Hadadi E, Johnston J, Ariaans M, Kraus R, Wilson H, Bauer R, Rader D, Francis S, Kiss-Toth E. Does myeloid expression of TRIB1 regulate plasma lipid levels? Atherosclerosis. 241: e34. DOI: 10.1016/J.Atherosclerosis.2015.04.125  0.341
2015 Rader DJ, Khetarpal SA. Lipoprotein physiology Dyslipidemias: Pathophysiology, Evaluation and Management. 1-12. DOI: 10.1007/978-1-60761-424-1_1  0.319
2014 Knowles JW, O'Brien EC, Greendale K, Wilemon K, Genest J, Sperling LS, Neal WA, Rader DJ, Khoury MJ. Reducing the burden of disease and death from familial hypercholesterolemia: a call to action. American Heart Journal. 168: 807-11. PMID 25458642 DOI: 10.1016/J.Ahj.2014.09.001  0.349
2014 Stitziel NO, Won HH, Morrison AC, Peloso GM, Do R, Lange LA, Fontanillas P, Gupta N, Duga S, Goel A, Farrall M, Saleheen D, Ferrario P, König I, ... ... Rader DJ, et al. Inactivating mutations in NPC1L1 and protection from coronary heart disease. The New England Journal of Medicine. 371: 2072-82. PMID 25390462 DOI: 10.1056/Nejmoa1405386  0.421
2014 Tuteja S, Rader DJ. Dyslipidaemia: cardiovascular prevention--end of the road for niacin? Nature Reviews. Endocrinology. 10: 646-7. PMID 25178730 DOI: 10.1038/Nrendo.2014.159  0.435
2014 Yang P, Belikova NA, Billheimer J, Rader DJ, Hill JS, Subbaiah PV. Inhibition of endothelial lipase activity by sphingomyelin in the lipoproteins. Lipids. 49: 987-96. PMID 25167836 DOI: 10.1007/S11745-014-3944-1  0.427
2014 Rader DJ, Hovingh GK. HDL and cardiovascular disease. Lancet (London, England). 384: 618-25. PMID 25131981 DOI: 10.1016/S0140-6736(14)61217-4  0.458
2014 Strong A, Patel K, Rader DJ. Sortilin and lipoprotein metabolism: making sense out of complexity. Current Opinion in Lipidology. 25: 350-7. PMID 25101658 DOI: 10.1097/Mol.0000000000000110  0.494
2014 Rader DJ. Spotlight on HDL biology: new insights in metabolism, function, and translation. Cardiovascular Research. 103: 337-40. PMID 25028388 DOI: 10.1093/Cvr/Cvu164  0.529
2014 Somanathan S, Jacobs F, Wang Q, Hanlon AL, Wilson JM, Rader DJ. AAV vectors expressing LDLR gain-of-function variants demonstrate increased efficacy in mouse models of familial hypercholesterolemia. Circulation Research. 115: 591-9. PMID 25023731 DOI: 10.1161/Circresaha.115.304008  0.473
2014 Anthanont P, Polisecki E, Asztalos BF, Diffenderfer MR, Barrett PH, Millar JS, Billheimer J, Cuchel M, Rader DJ, Schaefer EJ. A novel ApoA-I truncation (ApoA-IMytilene) associated with decreased ApoA-I production. Atherosclerosis. 235: 470-6. PMID 24950002 DOI: 10.1016/J.Atherosclerosis.2014.05.935  0.456
2014 Khetarpal SA, Rader DJ. Genetics of lipid traits: Genome-wide approaches yield new biology and clues to causality in coronary artery disease. Biochimica Et Biophysica Acta. 1842: 2010-2020. PMID 24931102 DOI: 10.1016/J.Bbadis.2014.06.007  0.426
2014 Ding Q, Strong A, Patel KM, Ng SL, Gosis BS, Regan SN, Cowan CA, Rader DJ, Musunuru K. Permanent alteration of PCSK9 with in vivo CRISPR-Cas9 genome editing. Circulation Research. 115: 488-92. PMID 24916110 DOI: 10.1161/Circresaha.115.304351  0.455
2014 Rosenson RS, Brewer HB, Rader DJ. Lipoproteins as biomarkers and therapeutic targets in the setting of acute coronary syndrome. Circulation Research. 114: 1880-9. PMID 24902972 DOI: 10.1161/Circresaha.114.302805  0.373
2014 Rader DJ. New therapies for coronary artery disease: genetics provides a blueprint. Science Translational Medicine. 6: 239ps4. PMID 24898745 DOI: 10.1126/Scitranslmed.3008535  0.331
2014 Javaheri A, Rader DJ. Apolipoprotein A-I and cholesterol efflux: the good, the bad, and the modified. Circulation Research. 114: 1681-3. PMID 24855198 DOI: 10.1161/Circresaha.114.303974  0.483
2014 Rahman M, Yang W, Akkina S, Alper A, Anderson AH, Appel LJ, He J, Raj DS, Schelling J, Strauss L, Teal V, Rader DJ. Relation of serum lipids and lipoproteins with progression of CKD: The CRIC study. Clinical Journal of the American Society of Nephrology : Cjasn. 9: 1190-8. PMID 24832097 DOI: 10.2215/Cjn.09320913  0.378
2014 Yang Y, Kuwano T, Lagor WR, Albert CJ, Brenton S, Rader DJ, Ford DA, Brown RJ. Lipidomic analyses of female mice lacking hepatic lipase and endothelial lipase indicate selective modulation of plasma lipid species. Lipids. 49: 505-15. PMID 24777581 DOI: 10.1007/S11745-014-3907-6  0.379
2014 Tuteja S, Rader DJ. High-density lipoproteins in the prevention of cardiovascular disease: Changing the paradigm Clinical Pharmacology and Therapeutics. 96: 48-56. PMID 24713591 DOI: 10.1038/Clpt.2014.79  0.463
2014 Hancock-Cerutti W, Rader DJ. Opposing effects of ABCG5/8 function on myocardial infarction and gallstone disease. Journal of the American College of Cardiology. 63: 2129-30. PMID 24657684 DOI: 10.1016/J.Jacc.2014.02.553  0.356
2014 Singh N, Jacobs F, Rader DJ, Vanhaecke J, Van Cleemput J, De Geest B. Impaired cholesterol efflux capacity and vasculoprotective function of high-density lipoprotein in heart transplant recipients. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society For Heart Transplantation. 33: 499-506. PMID 24630408 DOI: 10.1016/J.Healun.2014.01.859  0.391
2014 Mehta N, Qamar A, Qu L, Qasim AN, Mehta NN, Reilly MP, Rader DJ. Differential association of plasma angiopoietin-like proteins 3 and 4 with lipid and metabolic traits. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 1057-63. PMID 24626437 DOI: 10.1161/Atvbaha.113.302802  0.497
2014 Rader DJ, Kastelein JJ. Lomitapide and mipomersen: two first-in-class drugs for reducing low-density lipoprotein cholesterol in patients with homozygous familial hypercholesterolemia. Circulation. 129: 1022-32. PMID 24589695 DOI: 10.1161/Circulationaha.113.001292  0.508
2014 O'Brien EC, Roe MT, Fraulo ES, Peterson ED, Ballantyne CM, Genest J, Gidding SS, Hammond E, Hemphill LC, Hudgins LC, Kindt I, Moriarty PM, Ross J, Underberg JA, Watson K, ... ... Rader DJ, et al. Rationale and design of the familial hypercholesterolemia foundation CAscade SCreening for Awareness and DEtection of Familial Hypercholesterolemia registry. American Heart Journal. 167: 342-349.e17. PMID 24576518 DOI: 10.1016/J.Ahj.2013.12.008  0.382
2014 Tragante V, Barnes MR, Ganesh SK, Lanktree MB, Guo W, Franceschini N, Smith EN, Johnson T, Holmes MV, Padmanabhan S, Karczewski KJ, Almoguera B, Barnard J, Baumert J, Chang YP, ... ... Rader DJ, et al. Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. American Journal of Human Genetics. 94: 349-60. PMID 24560520 DOI: 10.1016/J.Ajhg.2013.12.016  0.367
2014 Lagor WR, Fields DW, Bauer RC, Crawford A, Abt MC, Artis D, Wherry EJ, Rader DJ. Genetic manipulation of the ApoF/Stat2 locus supports an important role for type I interferon signaling in atherosclerosis. Atherosclerosis. 233: 234-41. PMID 24529150 DOI: 10.1016/J.Atherosclerosis.2013.12.043  0.412
2014 Brown WV, Rader DJ, Goldberg AC. JCL roundtable: drug treatment of severe forms of familial hypercholesterolemia. Journal of Clinical Lipidology. 8: 10-7. PMID 24528683 DOI: 10.1016/J.Jacl.2013.09.004  0.423
2014 Roe A, Hillman J, Butts S, Smith M, Rader D, Playford M, Mehta NN, Dokras A. Decreased Cholesterol Efflux Capacity and Atherogenic Lipid Profile in Young Women With PCOS The Journal of Clinical Endocrinology and Metabolism. 99. PMID 24512495 DOI: 10.1210/Jc.2013-3918  0.432
2014 Peloso GM, Auer PL, Bis JC, Voorman A, Morrison AC, Stitziel NO, Brody JA, Khetarpal SA, Crosby JR, Fornage M, Isaacs A, Jakobsdottir J, Feitosa MF, Davies G, Huffman JE, ... ... Rader DJ, et al. Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks. American Journal of Human Genetics. 94: 223-32. PMID 24507774 DOI: 10.1016/J.Ajhg.2014.01.009  0.467
2014 Fruchart JC, Davignon J, Hermans MP, Al-Rubeaan K, Amarenco P, Assmann G, Barter P, Betteridge J, Bruckert E, Cuevas A, Farnier M, Ferrannini E, Fioretto P, Genest J, Ginsberg HN, ... ... Rader DJ, et al. Residual macrovascular risk in 2013: what have we learned? Cardiovascular Diabetology. 13: 26. PMID 24460800 DOI: 10.1186/1475-2840-13-26  0.404
2014 Miksztowicz V, Schreier L, McCoy M, Lucero D, Fassio E, Billheimer J, Rader DJ, Berg G. Role of SN1 lipases on plasma lipids in metabolic syndrome and obesity. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 669-75. PMID 24458708 DOI: 10.1161/Atvbaha.113.303027  0.351
2014 Rader DJ, deGoma EM. Future of cholesteryl ester transfer protein inhibitors. Annual Review of Medicine. 65: 385-403. PMID 24422575 DOI: 10.1146/Annurev-Med-050311-163305  0.394
2014 Li RC, Krishnamoorthy P, DerOhannessian S, Doveikis J, Wilcox M, Thomas P, Rader DJ, Reilly MP, Van Voorhees A, Gelfand JM, Mehta NN. Psoriasis is associated with decreased plasma adiponectin levels independently of cardiometabolic risk factors. Clinical and Experimental Dermatology. 39: 19-24. PMID 24341476 DOI: 10.1111/Ced.12250  0.324
2014 Mehta NN, Matthews GJ, Krishnamoorthy P, Shah R, McLaughlin C, Patel P, Budoff M, Chen J, Wolman M, Go A, He J, Kanetsky PA, Master SR, Rader DJ, Raj D, et al. Higher plasma CXCL12 levels predict incident myocardial infarction and death in chronic kidney disease: findings from the Chronic Renal Insufficiency Cohort study. European Heart Journal. 35: 2115-22. PMID 24306482 DOI: 10.1093/Eurheartj/Eht481  0.327
2014 Ruggles KV, Garbarino J, Liu Y, Moon J, Schneider K, Henneberry A, Billheimer J, Millar JS, Marchadier D, Valasek MA, Joblin-Mills A, Gulati S, Munkacsi AB, Repa JJ, Rader D, et al. A functional, genome-wide evaluation of liposensitive yeast identifies the "ARE2 required for viability" (ARV1) gene product as a major component of eukaryotic fatty acid resistance. The Journal of Biological Chemistry. 289: 4417-31. PMID 24273168 DOI: 10.1074/Jbc.M113.515197  0.369
2014 Javaheri A, Zamani P, Molina M, Rodriguez A, Chambers S, Stutman P, Williams M, Lukmanova D, Picataggi A, Woo J, Lilly S, Christie J, Goldberg L, Billheimer J, Rader D. Inverse Correlation of Cholesterol Efflux Capacity of High Density Lipoprotein With Survival After Cardiac Transplantation. Transplantation. 98: 426-427. DOI: 10.1097/00007890-201407151-01414  0.347
2014 Song W, Stubbe J, Ricciotti E, Dunbar RL, Rader DJ, FitzGerald GA. Systemic Eicosanoid and Cytokine Response to Niacin: Implications in HPS2-THRIVE Trial and Beyond†∗ Journal of Clinical Lipidology. 8: 309-310. DOI: 10.1016/J.Jacl.2014.02.030  0.4
2014 Koseki M, Hsieh J, Yakushiji E, Welch C, Iqbal J, Hussain M, Takiguchi S, Rader D, Sakata Y, Yamashita S, Tall A. TTC39B deficiency promotes HDL production and impairs non-hdl absorption in small intestine Atherosclerosis. 235: e104. DOI: 10.1016/J.Atherosclerosis.2014.05.279  0.316
2014 Julius U, Rader D, Gordon B, Moriarty P, Polk D, Parhofer K. Effects of lipoprotein apheresis (la) on serum pcsk9 levels Atherosclerosis. 235: e59-e60. DOI: 10.1016/J.Atherosclerosis.2014.05.147  0.331
2014 Pashos E, Lyssenko N, Picataggi A, Hernandez M, Liu Y, Yan R, Yang W, Morrisey E, Duncan S, Rader D. Tangier disease ipsc-derived hepatocytes recapitulate HDL biogenesis defects and display elevated triglyceride secretion Atherosclerosis. 235: e49-e50. DOI: 10.1016/J.Atherosclerosis.2014.05.115  0.375
2014 Hancock-Cerutti W, Lhomme M, Dauteuille C, Lecocq S, Chapman J, Rader D, Kontush A, Cuchel M. In hyperalphalipoproteinemic subjects, the presence of coronary artery disease is associated with marked changes in the HDL phosphosphingolipidome Atherosclerosis. 235: e48. DOI: 10.1016/J.Atherosclerosis.2014.05.111  0.324
2014 Hancock-Cerutti W, Zanoni P, Lhomme M, Lecocq S, Dauteuille C, Larach D, Chapman J, Cuchel M, Rader D, Kontush A. A deleterious mutation in scarb1 significantly alters HDL level, composition, and biological function in humans Atherosclerosis. 235: e46-e47. DOI: 10.1016/J.Atherosclerosis.2014.05.106  0.308
2013 Larach DB, Cuchel M, Rader DJ. Monogenic causes of elevated HDL cholesterol and implications for development of new therapeutics. Clinical Lipidology. 8: 635-648. PMID 25374625 DOI: 10.2217/Clp.13.73  0.498
2013 Brown WV, Rader DJ, Kane J. JCL Roundtable: diagnosis of severe familial hypercholesterolemia. Journal of Clinical Lipidology. 7: 540-5. PMID 24314353 DOI: 10.1016/J.Jacl.2013.08.003  0.407
2013 Javaheri A, Rader DJ. High-density lipoprotein: NO failure in heart failure. Circulation Research. 113: 1275-7. PMID 24311613 DOI: 10.1161/Circresaha.113.302667  0.505
2013 Hurt-Camejo E, Gautier T, Rosengren B, Dikkers A, Behrendt M, Grass DS, Rader DJ, Tietge UJ. Expression of type IIA secretory phospholipase A2 inhibits cholesteryl ester transfer protein activity in transgenic mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 2707-14. PMID 24115030 DOI: 10.1161/Atvbaha.113.301410  0.329
2013 Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang HY, Demirkan A, ... ... Rader DJ, et al. Discovery and refinement of loci associated with lipid levels. Nature Genetics. 45: 1274-83. PMID 24097068 DOI: 10.1038/Ng.2797  0.465
2013 Do R, Willer CJ, Schmidt EM, Sengupta S, Gao C, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang HY, ... ... Rader DJ, et al. Common variants associated with plasma triglycerides and risk for coronary artery disease. Nature Genetics. 45: 1345-52. PMID 24097064 DOI: 10.1038/Ng.2795  0.467
2013 Toth PP, Barter PJ, Rosenson RS, Boden WE, Chapman MJ, Cuchel M, D'Agostino RB, Davidson MH, Davidson WS, Heinecke JW, Karas RH, Kontush A, Krauss RM, Miller M, Rader DJ. High-density lipoproteins: a consensus statement from the National Lipid Association. Journal of Clinical Lipidology. 7: 484-525. PMID 24079290 DOI: 10.1016/J.Jacl.2013.08.001  0.458
2013 Stitziel NO, Fouchier SW, Sjouke B, Peloso GM, Moscoso AM, Auer PL, Goel A, Gigante B, Barnes TA, Melander O, Orho-Melander M, Duga S, Sivapalaratnam S, Nikpay M, Martinelli N, ... ... Rader DJ, et al. Exome sequencing and directed clinical phenotyping diagnose cholesterol ester storage disease presenting as autosomal recessive hypercholesterolemia. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 2909-14. PMID 24072694 DOI: 10.1161/Atvbaha.113.302426  0.387
2013 Chen SJ, Sanmiguel J, Lock M, McMenamin D, Draper C, Limberis MP, Kassim SH, Somanathan S, Bell P, Johnston JC, Rader DJ, Wilson JM. Biodistribution of AAV8 vectors expressing human low-density lipoprotein receptor in a mouse model of homozygous familial hypercholesterolemia. Human Gene Therapy. Clinical Development. 24: 154-60. PMID 24070336 DOI: 10.1089/Humc.2013.082  0.733
2013 Khera AV, Patel PJ, Reilly MP, Rader DJ. The addition of niacin to statin therapy improves high-density lipoprotein cholesterol levels but not metrics of functionality. Journal of the American College of Cardiology. 62: 1909-10. PMID 23933538 DOI: 10.1016/J.Jacc.2013.07.025  0.417
2013 Lagor WR, Johnston JC, Lock M, Vandenberghe LH, Rader DJ. Adeno-associated viruses as liver-directed gene delivery vehicles: focus on lipoprotein metabolism. Methods in Molecular Biology (Clifton, N.J.). 1027: 273-307. PMID 23912992 DOI: 10.1007/978-1-60327-369-5_13  0.317
2013 Keenan TE, Rader DJ. Genetics of lipid traits and relationship to coronary artery disease. Current Cardiology Reports. 15: 396. PMID 23881580 DOI: 10.1007/S11886-013-0396-9  0.47
2013 van Meurs JB, Pare G, Schwartz SM, Hazra A, Tanaka T, Vermeulen SH, Cotlarciuc I, Yuan X, Mälarstig A, Bandinelli S, Bis JC, Blom H, Brown MJ, Chen C, Chen YD, ... ... Rader DJ, et al. Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease. The American Journal of Clinical Nutrition. 98: 668-76. PMID 23824729 DOI: 10.3945/Ajcn.112.044545  0.343
2013 Khera AV, Rader DJ. Cholesterol efflux capacity: full steam ahead or a bump in the road? Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 1449-51. PMID 23766382 DOI: 10.1161/Atvbaha.113.301519  0.482
2013 Vickers KC, Rader DJ. Nuclear receptors and microRNA-144 coordinately regulate cholesterol efflux. Circulation Research. 112: 1529-31. PMID 23743223 DOI: 10.1161/Circresaha.113.301422  0.434
2013 Tatematsu S, Francis SA, Natarajan P, Rader DJ, Saghatelian A, Brown JD, Michel T, Plutzky J. Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 1788-94. PMID 23723371 DOI: 10.1161/Atvbaha.113.301300  0.364
2013 Picataggi A, Lim GF, Kent AP, Millar JS, Rader DJ, Stylianou IM. A coding variant in SR-BI (I179N) significantly increases atherosclerosis in mice. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 24: 257-65. PMID 23722970 DOI: 10.1007/S00335-013-9459-X  0.379
2013 Patel PJ, Khera AV, Wilensky RL, Rader DJ. Anti-oxidative and cholesterol efflux capacities of high-density lipoprotein are reduced in ischaemic cardiomyopathy. European Journal of Heart Failure. 15: 1215-9. PMID 23709232 DOI: 10.1093/Eurjhf/Hft084  0.431
2013 Zhou H, Castro-Perez J, Lassman ME, Thomas T, Li W, McLaughlin T, Dan X, Jumes P, Wagner JA, Gutstein DE, Hubbard BK, Rader DJ, Millar JS, Ginsberg HN, Reyes-Soffer G, et al. Measurement of apo(a) kinetics in human subjects using a microfluidic device with tandem mass spectrometry. Rapid Communications in Mass Spectrometry : Rcm. 27: 1294-302. PMID 23681806 DOI: 10.1002/Rcm.6572  0.322
2013 Kahn ML, Rader DJ. Lymphatics as a new active player in reverse cholesterol transport. Cell Metabolism. 17: 627-8. PMID 23663731 DOI: 10.1016/J.Cmet.2013.04.017  0.395
2013 Robciuc MR, Maranghi M, Lahikainen A, Rader D, Bensadoun A, Öörni K, Oörni K, Metso J, Minicocci I, Ciociola E, Ceci F, Montali A, Arca M, Ehnholm C, Jauhiainen M. Angptl3 deficiency is associated with increased insulin sensitivity, lipoprotein lipase activity, and decreased serum free fatty acids. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 1706-13. PMID 23661675 DOI: 10.1161/Atvbaha.113.301397  0.375
2013 Cuchel M, Rader DJ. Microsomal transfer protein inhibition in humans. Current Opinion in Lipidology. 24: 246-50. PMID 23594709 DOI: 10.1097/Mol.0B013E32836139Df  0.397
2013 Bose S, Krishnamoorthy P, Varanasi A, Nair J, Schutta M, Braunstein S, Iqbal N, Schwartz S, St Clair C, Master SR, Rader DJ, Reilly MP, Mehta NN. Measurement of waist circumference predicts coronary atherosclerosis beyond plasma adipokines. Obesity (Silver Spring, Md.). 21: E118-23. PMID 23505191 DOI: 10.1002/Oby.20086  0.309
2013 Master SR, Rader DJ. Beyond LDL cholesterol in assessing cardiovascular risk: apo B or LDL-P? Clinical Chemistry. 59: 723-5. PMID 23487171 DOI: 10.1373/Clinchem.2013.203208  0.426
2013 Li H, Dhanasekaran P, Alexander ET, Rader DJ, Phillips MC, Lund-Katz S. Molecular mechanisms responsible for the differential effects of apoE3 and apoE4 on plasma lipoprotein-cholesterol levels. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 687-93. PMID 23413428 DOI: 10.1161/Atvbaha.112.301193  0.408
2013 Ganesh SK, Tragante V, Guo W, Guo Y, Lanktree MB, Smith EN, Johnson T, Castillo BA, Barnard J, Baumert J, Chang YP, Elbers CC, Farrall M, Fischer ME, Franceschini N, ... ... Rader DJ, et al. Loci influencing blood pressure identified using a cardiovascular gene-centric array. Human Molecular Genetics. 22: 1663-78. PMID 23303523 DOI: 10.1093/Hmg/Dds555  0.315
2013 Kothapalli D, Castagnino P, Rader DJ, Phillips MC, Lund-Katz S, Assoian RK. Apolipoprotein E-mediated cell cycle arrest linked to p27 and the Cox2-dependent repression of miR221/222. Atherosclerosis. 227: 65-71. PMID 23294923 DOI: 10.1016/J.Atherosclerosis.2012.12.003  0.333
2013 Agarwala A, Billheimer J, Rader DJ. Atherosclerosis: Mighty minipig in fight against cardiovascular disease Science Translational Medicine. 5. PMID 23283365 DOI: 10.1126/Scitranslmed.3005369  0.33
2013 Deloukas P, Kanoni S, Willenborg C, Farrall M, Assimes TL, Thompson JR, Ingelsson E, Saleheen D, Erdmann J, Goldstein BA, Stirrups K, König IR, Cazier JB, Johansson A, ... ... Rader DJ, et al. Large-scale association analysis identifies new risk loci for coronary artery disease. Nature Genetics. 45: 25-33. PMID 23202125 DOI: 10.1038/Ng.2480  0.367
2013 Kassim SH, Li H, Bell P, Somanathan S, Lagor W, Jacobs F, Billheimer J, Wilson JM, Rader DJ. Adeno-associated virus serotype 8 gene therapy leads to significant lowering of plasma cholesterol levels in humanized mouse models of homozygous and heterozygous familial hypercholesterolemia. Human Gene Therapy. 24: 19-26. PMID 22985273 DOI: 10.1089/Hum.2012.108  0.752
2012 Tuteja S, Rader DJ. Genomic medicine in the prevention and treatment of atherosclerotic cardiovascular disease. Personalized Medicine. 9: 395-404. PMID 29776260 DOI: 10.2217/Pme.12.34  0.305
2012 Elbers CC, Guo Y, Tragante V, van Iperen EP, Lanktree MB, Castillo BA, Chen F, Yanek LR, Wojczynski MK, Li YR, Ferwerda B, Ballantyne CM, Buxbaum SG, Chen YD, Chen WM, ... ... Rader DJ, et al. Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic populations. Plos One. 7: e50198. PMID 23236364 DOI: 10.1371/Journal.Pone.0050198  0.386
2012 Miksztowicz V, McCoy MG, Schreier L, Cacciagiú L, Elbert A, Gonzalez AI, Billheimer J, Eacho P, Rader DJ, Berg G. Endothelial lipase activity predicts high-density lipoprotein catabolism in hemodialysis: novel phospholipase assay in postheparin human plasma. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 3033-40. PMID 23104846 DOI: 10.1161/Atvbaha.112.300110  0.356
2012 Kothapalli D, Liu SL, Bae YH, Monslow J, Xu T, Hawthorne EA, Byfield FJ, Castagnino P, Rao S, Rader DJ, Puré E, Phillips MC, Lund-Katz S, Janmey PA, Assoian RK. Cardiovascular Protection by ApoE and ApoE-HDL Linked to Suppression of ECM Gene Expression and Arterial Stiffening Cell Reports. 2: 1259-1271. PMID 23103162 DOI: 10.1016/J.Celrep.2012.09.018  0.425
2012 Asselbergs FW, Guo Y, van Iperen EP, Sivapalaratnam S, Tragante V, Lanktree MB, Lange LA, Almoguera B, Appelman YE, Barnard J, Baumert J, Beitelshees AL, Bhangale TR, Chen YD, Gaunt TR, ... ... Rader DJ, et al. Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. American Journal of Human Genetics. 91: 823-38. PMID 23063622 DOI: 10.1016/J.Ajhg.2012.08.032  0.447
2012 Rader DJ, DeGoma EM. Approach to the patient with extremely low HDL-cholesterol Journal of Clinical Endocrinology and Metabolism. 97: 3399-3407. PMID 23043194 DOI: 10.1210/Jc.2012-2185  0.457
2012 Larach DB, deGoma EM, Rader DJ. Targeting High Density Lipoproteins in the Prevention of Cardiovascular Disease Current Cardiology Reports. 14: 684-691. PMID 22991041 DOI: 10.1007/S11886-012-0317-3  0.446
2012 Rader DJ, Tall AR. The not-so-simple HDL story: Is it time to revise the HDL cholesterol hypothesis? Nature Medicine. 18: 1344-6. PMID 22961164 DOI: 10.1038/Nm.2937  0.42
2012 Lauring B, Taggart AK, Tata JR, Dunbar R, Caro L, Cheng K, Chin J, Colletti SL, Cote J, Khalilieh S, Liu J, Luo WL, Maclean AA, Peterson LB, Polis AB, ... ... Rader DJ, et al. Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression. Science Translational Medicine. 4: 148ra115. PMID 22914621 DOI: 10.1126/Scitranslmed.3003877  0.409
2012 Mehta NN, Li R, Krishnamoorthy P, Yu Y, Farver W, Rodrigues A, Raper A, Wilcox M, Baer A, DerOhannesian S, Wolfe M, Reilly MP, Rader DJ, VanVoorhees A, Gelfand JM. Abnormal lipoprotein particles and cholesterol efflux capacity in patients with psoriasis. Atherosclerosis. 224: 218-21. PMID 22858285 DOI: 10.1016/J.Atherosclerosis.2012.06.068  0.386
2012 Degoma EM, Rader DJ. High-density lipoprotein particle number: A better measure to quantify high-density lipoprotein? Journal of the American College of Cardiology. 60: 517-520. PMID 22796252 DOI: 10.1016/J.Jacc.2012.03.058  0.355
2012 Strong A, Ding Q, Edmondson AC, Millar JS, Sachs KV, Li X, Kumaravel A, Wang MY, Ai D, Guo L, Alexander ET, Nguyen D, Lund-Katz S, Phillips MC, Morales CR, ... ... Rader DJ, et al. Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism. The Journal of Clinical Investigation. 122: 2807-16. PMID 22751103 DOI: 10.1172/Jci63563  0.686
2012 Jin SY, Tohyama J, Bauer RC, Cao NN, Rader DJ, Zheng XL. Genetic ablation of Adamts13 gene dramatically accelerates the formation of early atherosclerosis in a murine model. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 1817-23. PMID 22652598 DOI: 10.1161/Atvbaha.112.247262  0.322
2012 Ashley EA, Hershberger RE, Caleshu C, Ellinor PT, Garcia JG, Herrington DM, Ho CY, Johnson JA, Kittner SJ, Macrae CA, Mudd-Martin G, Rader DJ, Roden DM, Scholes D, Sellke FW, et al. Genetics and cardiovascular disease: a policy statement from the American Heart Association. Circulation. 126: 142-57. PMID 22645291 DOI: 10.1161/Cir.0B013E31825B07F8  0.304
2012 Musunuru K, Romaine SP, Lettre G, Wilson JG, Volcik KA, Tsai MY, Taylor HA, Schreiner PJ, Rotter JI, Rich SS, Redline S, Psaty BM, Papanicolaou GJ, Ordovas JM, Liu K, ... ... Rader DJ, et al. Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project. Plos One. 7: e36473. PMID 22629316 DOI: 10.1371/Journal.Pone.0036473  0.411
2012 Voight BF, Peloso GM, Orho-Melander M, Frikke-Schmidt R, Barbalic M, Jensen MK, Hindy G, Hólm H, Ding EL, Johnson T, Schunkert H, Samani NJ, Clarke R, Hopewell JC, Thompson JF, ... ... Rader DJ, et al. Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet. 380: 572-80. PMID 22607825 DOI: 10.1016/S0140-6736(12)60312-2  0.318
2012 Strong A, Rader DJ. Sortilin as a regulator of lipoprotein metabolism. Current Atherosclerosis Reports. 14: 211-8. PMID 22538429 DOI: 10.1007/S11883-012-0248-X  0.464
2012 Rosenson RS, Brewer HB, Davidson WS, Fayad ZA, Fuster V, Goldstein J, Hellerstein M, Jiang XC, Phillips MC, Rader DJ, Remaley AT, Rothblat GH, Tall AR, Yvan-Charvet L. Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport. Circulation. 125: 1905-19. PMID 22508840 DOI: 10.1161/Circulationaha.111.066589  0.445
2012 Dastani Z, Hivert MF, Timpson N, Perry JR, Yuan X, Scott RA, Henneman P, Heid IM, Kizer JR, Lyytikäinen LP, Fuchsberger C, Tanaka T, Morris AP, Small K, Isaacs A, ... ... Rader DJ, et al. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. Plos Genetics. 8: e1002607. PMID 22479202 DOI: 10.1371/Journal.Pgen.1002607  0.621
2012 Diffenderfer MR, Brousseau ME, Millar JS, Barrett PH, Nartsupha C, Schaefer PM, Wolfe ML, Dolnikowski GG, Rader DJ, Schaefer EJ. Effects of CETP inhibition on triglyceride-rich lipoprotein composition and apoB-48 metabolism. Journal of Lipid Research. 53: 1190-9. PMID 22474066 DOI: 10.1194/Jlr.M019570  0.35
2012 Ai D, Baez JM, Jiang H, Conlon DM, Hernandez-Ono A, Frank-Kamenetsky M, Milstein S, Fitzgerald K, Murphy AJ, Woo CW, Strong A, Ginsberg HN, Tabas I, Rader DJ, Tall AR. Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice. The Journal of Clinical Investigation. 122: 1677-87. PMID 22466652 DOI: 10.1172/Jci61248  0.337
2012 Sarwar N, Butterworth AS, Freitag DF, Gregson J, Willeit P, Gorman DN, Gao P, Saleheen D, Rendon A, Nelson CP, Braund PS, Hall AS, Chasman DI, Tybjærg-Hansen A, ... ... Rader DJ, et al. Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet. 379: 1205-13. PMID 22421339 DOI: 10.1016/S0140-6736(11)61931-4  0.307
2012 Annema W, Dikkers A, De Boer JF, Gautier T, Rensen PCN, Rader DJ, Tietge UJF. ApoE promotes hepatic selective uptake but not RCT due to increased ABCA1-mediated cholesterol efflux to plasma Journal of Lipid Research. 53: 929-940. PMID 22383685 DOI: 10.1194/Jlr.M020743  0.435
2012 Lagor WR, Fields DW, Khetarpal SA, Kumaravel A, Lin W, Weintraub N, Wu K, Hamm-Alvarez SF, Drazul-Schrader D, de la Llera-Moya M, Rothblat GH, Rader DJ. The effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in mice. Plos One. 7: e31616. PMID 22363685 DOI: 10.1371/Journal.Pone.0031616  0.449
2012 Ferguson JF, Hinkle CC, Mehta NN, Bagheri R, Derohannessian SL, Shah R, Mucksavage MI, Bradfield JP, Hakonarson H, Wang X, Master SR, Rader DJ, Li M, Reilly MP. Translational studies of lipoprotein-associated phospholipase A₂ in inflammation and atherosclerosis. Journal of the American College of Cardiology. 59: 764-72. PMID 22340269 DOI: 10.1016/J.Jacc.2011.11.019  0.384
2012 Davies RW, Wells GA, Stewart AF, Erdmann J, Shah SH, Ferguson JF, Hall AS, Anand SS, Burnett MS, Epstein SE, Dandona S, Chen L, Nahrstaedt J, Loley C, König IR, ... ... Rader DJ, et al. A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex. Circulation. Cardiovascular Genetics. 5: 217-25. PMID 22319020 DOI: 10.1161/Circgenetics.111.961243  0.336
2012 Stylianou IM, Bauer RC, Reilly MP, Rader DJ. Genetic basis of atherosclerosis: insights from mice and humans. Circulation Research. 110: 337-55. PMID 22267839 DOI: 10.1161/Circresaha.110.230854  0.366
2012 O'Connell DP, LeBlanc DF, Cromley D, Billheimer J, Rader DJ, Bachovchin WW. Design and synthesis of boronic acid inhibitors of endothelial lipase. Bioorganic & Medicinal Chemistry Letters. 22: 1397-401. PMID 22225633 DOI: 10.1016/J.Bmcl.2011.12.043  0.373
2012 deGoma EM, Knowles JW, Angeli F, Budoff MJ, Rader DJ. The evolution and refinement of traditional risk factors for cardiovascular disease. Cardiology in Review. 20: 118-29. PMID 22183062 DOI: 10.1097/Crd.0B013E318239B924  0.336
2012 Farouk SS, Rader DJ, Reilly MP, Mehta NN. CXCL12: a new player in coronary disease identified through human genetics. Trends in Cardiovascular Medicine. 20: 204-9. PMID 22137643 DOI: 10.1016/J.Tcm.2011.08.002  0.352
2012 He J, Li H, Edmondson AC, Rader DJ, Li M. A Gaussian copula approach for the analysis of secondary phenotypes in case-control genetic association studies. Biostatistics (Oxford, England). 13: 497-508. PMID 21933777 DOI: 10.1093/Biostatistics/Kxr025  0.666
2012 Martin SS, Qasim AN, Rader DJ, Reilly MP. C-reactive protein modifies the association of plasma leptin with coronary calcium in asymptomatic overweight individuals. Obesity. 20: 856-861. PMID 21738237 DOI: 10.1038/Oby.2011.164  0.332
2012 Easton R, Gille A, Leary E, Shear C, Rader D, Wright SD. CSL112, A NOVEL FORMULATION OF HUMAN APOA-I, ROBUSTLY ENHANCES THE ABILITY OF SERUM TO EFFLUX CHOLESTEROL Journal of the American College of Cardiology. 59: E490. DOI: 10.1016/S0735-1097(12)60491-4  0.434
2012 Rader DJ. Strategies for Early Detection: The Role of Genetic Testing in Patients with Severe Hypercholesterolemia Journal of Clinical Lipidology. 6: S4-S5. DOI: 10.1016/J.Jacl.2012.10.010  0.34
2011 Wang K, Edmondson AC, Li M, Gao F, Qasim AN, Devaney JM, Burnett MS, Waterworth DM, Mooser V, Grant SF, Epstein SE, Reilly MP, Hakonarson H, Rader DJ. Pathway-Wide Association Study Implicates Multiple Sterol Transport and Metabolism Genes in HDL Cholesterol Regulation. Frontiers in Genetics. 2: 41. PMID 22303337 DOI: 10.3389/Fgene.2011.00041  0.697
2011 Khetarpal SA, Edmondson AC, Raghavan A, Neeli H, Jin W, Badellino KO, Demissie S, Manning AK, DerOhannessian SL, Wolfe ML, Cupples LA, Li M, Kathiresan S, Rader DJ. Mining the LIPG allelic spectrum reveals the contribution of rare and common regulatory variants to HDL cholesterol. Plos Genetics. 7: e1002393. PMID 22174694 DOI: 10.1371/Journal.Pgen.1002393  0.691
2011 Patel PJ, Khera AV, Jafri K, Wilensky RL, Rader DJ. The anti-oxidative capacity of high-density lipoprotein is reduced in acute coronary syndrome but not in stable coronary artery disease. Journal of the American College of Cardiology. 58: 2068-75. PMID 22051328 DOI: 10.1016/J.Jacc.2011.08.030  0.362
2011 Lecker JL, Matthan NR, Billheimer JT, Rader DJ, Lichtenstein AH. Changes in cholesterol homeostasis modify the response of F1B hamsters to dietary very long chain n-3 and n-6 polyunsaturated fatty acids. Lipids in Health and Disease. 10: 186. PMID 22018327 DOI: 10.1186/1476-511X-10-186  0.417
2011 McGillicuddy FC, Reilly MP, Rader DJ. Adipose modulation of high-density lipoprotein cholesterol: implications for obesity, high-density lipoprotein metabolism, and cardiovascular disease. Circulation. 124: 1602-5. PMID 21986773 DOI: 10.1161/Circulationaha.111.058453  0.484
2011 Weibel GL, Hayes S, Wilson A, Phillips MC, Billheimer J, Rader DJ, Rothblat GH. Novel in vivo method for measuring cholesterol mass flux in peripheral macrophages. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 2865-71. PMID 21940945 DOI: 10.1161/Atvbaha.111.236406  0.399
2011 Yamamoto S, Tanigawa H, Li X, Komaru Y, Billheimer JT, Rader DJ. Pharmacologic suppression of hepatic ATP-binding cassette transporter 1 activity in mice reduces high-density lipoprotein cholesterol levels but promotes reverse cholesterol transport. Circulation. 124: 1382-90. PMID 21859969 DOI: 10.1161/Circulationaha.110.009704  0.423
2011 Brown JD, Oligino E, Rader DJ, Saghatelian A, Plutzky J. VLDL hydrolysis by hepatic lipase regulates PPARδ transcriptional responses. Plos One. 6: e21209. PMID 21750705 DOI: 10.1371/Journal.Pone.0021209  0.362
2011 Kassim SH, Vandenberghe LH, Hovhannisyan R, Wilson JM, Rader DJ. Identification and functional characterization in vivo of a novel splice variant of LDLR in rhesus macaques. Physiological Genomics. 43: 911-6. PMID 21628398 DOI: 10.1152/Physiolgenomics.00006.2011  0.718
2011 Wild PS, Zeller T, Schillert A, Szymczak S, Sinning CR, Deiseroth A, Schnabel RB, Lubos E, Keller T, Eleftheriadis MS, Bickel C, Rupprecht HJ, Wilde S, Rossmann H, Diemert P, ... ... Rader DJ, et al. A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease. Circulation. Cardiovascular Genetics. 4: 403-12. PMID 21606135 DOI: 10.1161/Circgenetics.110.958728  0.351
2011 Hopkins PN, Toth PP, Ballantyne CM, Rader DJ. Familial hypercholesterolemias: Prevalence, genetics, diagnosis and screening recommendations from the National Lipid Association Expert Panel on Familial Hypercholesterolemia Journal of Clinical Lipidology. 5. PMID 21600530 DOI: 10.1016/J.Jacl.2011.03.452  0.333
2011 Goldberg AC, Hopkins PN, Toth PP, Ballantyne CM, Rader DJ, Robinson JG, Daniels SR, Gidding SS, de Ferranti SD, Ito MK, McGowan MP, Moriarty PM, Cromwell WC, Ross JL, Ziajka PE, et al. Familial hypercholesterolemia: screening, diagnosis and management of pediatric and adult patients: clinical guidance from the National Lipid Association Expert Panel on Familial Hypercholesterolemia. Journal of Clinical Lipidology. 5: S1-8. PMID 21600525 DOI: 10.1016/J.Jacl.2011.04.003  0.42
2011 Goldberg AC, Hopkins PN, Toth PP, Ballantyne CM, Rader DJ, Robinson JG, Daniels SR, Gidding SS, de Ferranti SD, Ito MK, McGowan MP, Moriarty PM, Cromwell WC, Ross JL, Ziajka PE. Familial hypercholesterolemia: screening, diagnosis and management of pediatric and adult patients: clinical guidance from the National Lipid Association Expert Panel on Familial Hypercholesterolemia. Journal of Clinical Lipidology. 5: 133-40. PMID 21600517 DOI: 10.1016/J.Jacl.2011.03.001  0.42
2011 Potteaux S, Gautier EL, Hutchison SB, van Rooijen N, Rader DJ, Thomas MJ, Sorci-Thomas MG, Randolph GJ. Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of Apoe-/- mice during disease regression. The Journal of Clinical Investigation. 121: 2025-36. PMID 21505265 DOI: 10.1172/Jci43802  0.398
2011 Rak K, Rader DJ. Cardiovascular disease: The diet-microbe morbid union Nature. 472: 40-41. PMID 21475185 DOI: 10.1038/472040A  0.364
2011 Nakaya K, Tohyama J, Naik SU, Tanigawa H, MacPhee C, Billheimer JT, Rader DJ. Peroxisome proliferator-activated receptor-α activation promotes macrophage reverse cholesterol transport through a liver X receptor-dependent pathway. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 1276-82. PMID 21441141 DOI: 10.1161/Atvbaha.111.225383  0.328
2011 Schunkert H, König IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, Preuss M, Stewart AF, Barbalic M, Gieger C, Absher D, Aherrahrou Z, Allayee H, Altshuler D, Anand SS, ... ... Rader DJ, et al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nature Genetics. 43: 333-8. PMID 21378990 DOI: 10.1038/Ng.784  0.35
2011 Lettre G, Palmer CD, Young T, Ejebe KG, Allayee H, Benjamin EJ, Bennett F, Bowden DW, Chakravarti A, Dreisbach A, Farlow DN, Folsom AR, Fornage M, Forrester T, Fox E, ... ... Rader DJ, et al. Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. Plos Genetics. 7: e1001300. PMID 21347282 DOI: 10.1371/Journal.Pgen.1001300  0.379
2011 Bauer RC, Stylianou IM, Rader DJ. Functional validation of new pathways in lipoprotein metabolism identified by human genetics. Current Opinion in Lipidology. 22: 123-8. PMID 21311327 DOI: 10.1097/Mol.0B013E32834469B3  0.374
2011 Edmondson AC, Braund PS, Stylianou IM, Khera AV, Nelson CP, Wolfe ML, Derohannessian SL, Keating BJ, Qu L, He J, Tobin MD, Tomaszewski M, Baumert J, Klopp N, Döring A, ... ... Rader DJ, et al. Dense genotyping of candidate gene loci identifies variants associated with high-density lipoprotein cholesterol. Circulation. Cardiovascular Genetics. 4: 145-55. PMID 21303902 DOI: 10.1161/Circgenetics.110.957563  0.702
2011 Nijstad N, de Boer JF, Lagor WR, Toelle M, Usher D, Annema W, der Giet Mv, Rader DJ, Tietge UJ. Overexpression of apolipoprotein O does not impact on plasma HDL levels or functionality in human apolipoprotein A-I transgenic mice. Biochimica Et Biophysica Acta. 1811: 294-9. PMID 21296681 DOI: 10.1016/J.Bbalip.2011.01.008  0.449
2011 Toh SA, Millar JS, Billheimer J, Fuki I, Naik SU, Macphee C, Walker M, Rader DJ. PPARγ activation redirects macrophage cholesterol from fecal excretion to adipose tissue uptake in mice via SR-BI. Biochemical Pharmacology. 81: 934-41. PMID 21291868 DOI: 10.1016/J.Bcp.2011.01.012  0.398
2011 Mehta NN, Krishnamoorthy P, Martin SS, St Clair C, Schwartz S, Iqbal N, Braunstein S, Schutta M, Rader DJ, Reilly MP. Usefulness of insulin resistance estimation and the metabolic syndrome in predicting coronary atherosclerosis in type 2 diabetes mellitus. The American Journal of Cardiology. 107: 406-11. PMID 21257006 DOI: 10.1016/J.Amjcard.2010.09.035  0.303
2011 Martin SS, Qasim AN, Wolfe M, St Clair C, Schwartz S, Iqbal N, Schutta M, Bagheri R, Mehta NN, Rader DJ, Reilly MP. Comparison of high-density lipoprotein cholesterol to apolipoprotein A-I and A-II to predict coronary calcium and the effect of insulin resistance. The American Journal of Cardiology. 107: 393-8. PMID 21257004 DOI: 10.1016/J.Amjcard.2010.09.033  0.392
2011 Degoma EM, Rader DJ. Novel HDL-directed pharmacotherapeutic strategies Nature Reviews Cardiology. 8: 266-277. PMID 21243009 DOI: 10.1038/Nrcardio.2010.200  0.45
2011 Reilly MP, Li M, He J, Ferguson JF, Stylianou IM, Mehta NN, Burnett MS, Devaney JM, Knouff CW, Thompson JR, Horne BD, Stewart AF, Assimes TL, Wild PS, Allayee H, ... ... Rader DJ, et al. Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. Lancet. 377: 383-92. PMID 21239051 DOI: 10.1016/S0140-6736(10)61996-4  0.306
2011 Khera AV, Cuchel M, de la Llera-Moya M, Rodrigues A, Burke MF, Jafri K, French BC, Phillips JA, Mucksavage ML, Wilensky RL, Mohler ER, Rothblat GH, Rader DJ. Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis. The New England Journal of Medicine. 364: 127-35. PMID 21226578 DOI: 10.1056/Nejmoa1001689  0.438
2011 Nijstad N, Gautier T, Briand F, Rader DJ, Tietge UJ. Biliary sterol secretion is required for functional in vivo reverse cholesterol transport in mice. Gastroenterology. 140: 1043-51. PMID 21134376 DOI: 10.1053/J.Gastro.2010.11.055  0.428
2011 Lagor WR, Rader DJ. Phospholipidation of HDL-how much is too much? Clinical Chemistry. 57: 4-6. PMID 21078838 DOI: 10.1373/Clinchem.2010.156224  0.434
2011 Alexander ET, Vedhachalam C, Sankaranarayanan S, de la Llera-Moya M, Rothblat GH, Rader DJ, Phillips MC. Influence of apolipoprotein A-I domain structure on macrophage reverse cholesterol transport in mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 320-7. PMID 21071688 DOI: 10.1161/Atvbaha.110.216226  0.342
2011 Millar JS, Ikewaki K, Bloedon LT, Wolfe ML, Szapary PO, Rader DJ. Effect of rosiglitazone on HDL metabolism in subjects with metabolic syndrome and low HDL. Journal of Lipid Research. 52: 136-42. PMID 20971975 DOI: 10.1194/Jlr.P008136  0.367
2011 He J, Wang K, Edmondson AC, Rader DJ, Li C, Li M. Gene-based interaction analysis by incorporating external linkage disequilibrium information. European Journal of Human Genetics : Ejhg. 19: 164-72. PMID 20924406 DOI: 10.1038/Ejhg.2010.164  0.612
2011 Qasim AN, Budharaju V, Mehta NN, St Clair C, Farouk S, Braunstein S, Schutta M, Iqbal N, Rader DJ, Reilly MP. Gender differences in the association of C-reactive protein with coronary artery calcium in type-2 diabetes. Clinical Endocrinology. 74: 44-50. PMID 20874770 DOI: 10.1111/J.1365-2265.2010.03879.X  0.314
2011 Butterworth AS, Braund PS, Farrall M, Hardwick RJ, Saleheen D, Peden JF, Soranzo N, Chambers JC, Sivapalaratnam S, Kleber ME, Keating B, Qasim A, Klopp N, Erdmann J, Assimes TL, ... ... Rader DJ, et al. Large-scale gene-centric analysis identifies novel variants for coronary artery disease Plos Genetics. 7. DOI: 10.1371/Journal.Pgen.1002260  0.365
2011 Barter PJ, Chapman MJ, Rader DJ, Rosenson RS, Schaefer EJ. Translating HDL Science to Clinical Practice Journal of Clinical Lipidology. 5: S6-S7. DOI: 10.1016/J.Jacl.2011.10.011  0.462
2010 Kassim SH, Wilson JM, Rader DJ. Gene therapy for dyslipidemia: a review of gene replacement and gene inhibition strategies. Clinical Lipidology. 5: 793-809. PMID 22505953 DOI: 10.2217/Clp.10.73  0.716
2010 Strong A, Rader DJ. Clinical Implications of Lipid Genetics for Cardiovascular Disease. Current Cardiovascular Risk Reports. 4: 461-468. PMID 21853159 DOI: 10.1007/S12170-010-0131-7  0.434
2010 Nijjar PS, Burke FM, Bloesch A, Rader DJ. Role of dietary supplements in lowering low-density lipoprotein cholesterol: a review. Journal of Clinical Lipidology. 4: 248-58. PMID 21122657 DOI: 10.1016/J.Jacl.2010.07.001  0.456
2010 Burkhardt R, Toh SA, Lagor WR, Birkeland A, Levin M, Li X, Robblee M, Fedorov VD, Yamamoto M, Satoh T, Akira S, Kathiresan S, Breslow JL, Rader DJ. Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice. The Journal of Clinical Investigation. 120: 4410-4. PMID 21084752 DOI: 10.1172/Jci44213  0.452
2010 Kassim SH, Li H, Vandenberghe LH, Hinderer C, Bell P, Marchadier D, Wilson A, Cromley D, Redon V, Yu H, Wilson JM, Rader DJ. Gene therapy in a humanized mouse model of familial hypercholesterolemia leads to marked regression of atherosclerosis. Plos One. 5: e13424. PMID 20976059 DOI: 10.1371/Journal.Pone.0013424  0.744
2010 Yasuda T, Ishida T, Rader DJ. Update on the role of endothelial lipase in high-density lipoprotein metabolism, reverse cholesterol transport, and atherosclerosis. Circulation Journal : Official Journal of the Japanese Circulation Society. 74: 2263-70. PMID 20962428 DOI: 10.1253/Circj.Cj-10-0934  0.458
2010 Preuss M, König IR, Thompson JR, Erdmann J, Absher D, Assimes TL, Blankenberg S, Boerwinkle E, Chen L, Cupples LA, Hall AS, Halperin E, Hengstenberg C, Holm H, Laaksonen R, ... ... Rader DJ, et al. Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: A Genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls. Circulation. Cardiovascular Genetics. 3: 475-83. PMID 20923989 DOI: 10.1161/Circgenetics.109.899443  0.305
2010 Waterworth DM, Ricketts SL, Song K, Chen L, Zhao JH, Ripatti S, Aulchenko YS, Zhang W, Yuan X, Lim N, Luan J, Ashford S, Wheeler E, Young EH, Hadley D, ... ... Rader DJ, et al. Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 2264-76. PMID 20864672 DOI: 10.1161/Atvbaha.109.201020  0.469
2010 Khera AV, Wolfe ML, Cannon CP, Qin J, Rader DJ. On-statin cholesteryl ester transfer protein mass and risk of recurrent coronary events (from the pravastatin or atorvastatin evaluation and infection therapy-thrombolysis in myocardial infarction 22 [PROVE IT-TIMI 22] study). The American Journal of Cardiology. 106: 451-6. PMID 20691300 DOI: 10.1016/J.Amjcard.2010.03.057  0.421
2010 Musunuru K, Strong A, Frank-Kamenetsky M, Lee NE, Ahfeldt T, Sachs KV, Li X, Li H, Kuperwasser N, Ruda VM, Pirruccello JP, Muchmore B, Prokunina-Olsson L, Hall JL, Schadt EE, ... ... Rader DJ, et al. From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature. 466: 714-9. PMID 20686566 DOI: 10.1038/Nature09266  0.451
2010 Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP, Ripatti S, Chasman DI, Willer CJ, Johansen CT, Fouchier SW, Isaacs A, Peloso GM, Barbalic M, ... ... Rader DJ, et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 466: 707-13. PMID 20686565 DOI: 10.1038/Nature09270  0.71
2010 Tong F, Billheimer J, Shechtman CF, Liu Y, Crooke R, Graham M, Cohen DE, Sturley SL, Rader DJ. Decreased expression of ARV1 results in cholesterol retention in the endoplasmic reticulum and abnormal bile acid metabolism. The Journal of Biological Chemistry. 285: 33632-41. PMID 20663892 DOI: 10.1074/Jbc.M110.165761  0.372
2010 Li X, Millar JS, Brownell N, Briand F, Rader DJ. Modulation of HDL metabolism by the niacin receptor GPR109A in mouse hepatocytes. Biochemical Pharmacology. 80: 1450-7. PMID 20655299 DOI: 10.1016/J.Bcp.2010.07.023  0.445
2010 Gretarsdottir S, Baas AF, Thorleifsson G, Holm H, den Heijer M, de Vries JP, Kranendonk SE, Zeebregts CJ, van Sterkenburg SM, Geelkerken RH, van Rij AM, Williams MJ, Boll AP, Kostic JP, Jonasdottir A, ... ... Rader DJ, et al. Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm. Nature Genetics. 42: 692-7. PMID 20622881 DOI: 10.1038/Ng.622  0.311
2010 Liu J, Afroza H, Rader DJ, Jin W. Angiopoietin-like protein 3 inhibits lipoprotein lipase activity through enhancing its cleavage by proprotein convertases. The Journal of Biological Chemistry. 285: 27561-70. PMID 20581395 DOI: 10.1074/Jbc.M110.144279  0.367
2010 Brown RJ, Lagor WR, Sankaranaravanan S, Yasuda T, Quertermous T, Rothblat GH, Rader DJ. Impact of combined deficiency of hepatic lipase and endothelial lipase on the metabolism of both high-density lipoproteins and apolipoprotein B-containing lipoproteins. Circulation Research. 107: 357-64. PMID 20558822 DOI: 10.1161/Circresaha.110.219188  0.389
2010 Khera AV, Rader DJ. Future therapeutic directions in reverse cholesterol transport Current Atherosclerosis Reports. 12: 73-81. PMID 20425274 DOI: 10.1007/S11883-009-0080-0  0.444
2010 Burke MF, Khera AV, Rader DJ. Polyphenols and cholesterol efflux: is coffee the next red wine? Circulation Research. 106: 627-9. PMID 20203311 DOI: 10.1161/Circresaha.109.215855  0.456
2010 Lecker JL, Matthan NR, Billheimer JT, Rader DJ, Lichtenstein AH. Impact of dietary fat type within the context of altered cholesterol homeostasis on cholesterol and lipoprotein metabolism in the F1B hamster. Metabolism: Clinical and Experimental. 59: 1491-501. PMID 20197195 DOI: 10.1016/J.Metabol.2010.01.014  0.45
2010 Halbert SC, French B, Gordon RY, Farrar JT, Schmitz K, Morris PB, Thompson PD, Rader DJ, Becker DJ. Tolerability of red yeast rice (2,400 mg twice daily) versus pravastatin (20 mg twice daily) in patients with previous statin intolerance. The American Journal of Cardiology. 105: 198-204. PMID 20102918 DOI: 10.1016/J.Amjcard.2009.08.672  0.36
2010 de la Llera-Moya M, Drazul-Schrader D, Asztalos BF, Cuchel M, Rader DJ, Rothblat GH. The ability to promote efflux via ABCA1 determines the capacity of serum specimens with similar high-density lipoprotein cholesterol to remove cholesterol from macrophages. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 796-801. PMID 20075420 DOI: 10.1161/Atvbaha.109.199158  0.43
2010 Cuchel M, Lund-Katz S, de la Llera-Moya M, Millar JS, Chang D, Fuki I, Rothblat GH, Phillips MC, Rader DJ. Pathways by which reconstituted high-density lipoprotein mobilizes free cholesterol from whole body and from macrophages. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 526-32. PMID 20018934 DOI: 10.1161/Atvbaha.109.196105  0.403
2010 Shah A, Rader DJ, Millar JS. The effect of PPAR-α agonism on apolipoprotein metabolism in humans Atherosclerosis. 210: 35-40. PMID 20005515 DOI: 10.1016/J.Atherosclerosis.2009.11.010  0.413
2010 Foster GD, Wyatt HR, Hill JO, Makris AP, Rosenbaum DL, Brill C, Stein RI, Mohammed S, Miller B, Rader DJ, Zemel B, Wadden TA, Tenhave T, Newcomb CW, Klein S. Weight and Metabolic Outcomes After 2 Years on a Low-Carbohydrate Versus Low-Fat Diet Obstetrical & Gynecological Survey. 65: 769-770. DOI: 10.1097/Ogx.0B013E31821342Ba  0.303
2010 Qasim A, Matthews L, Movva R, Parcham-Azad K, Rader DJ, Reilly MP. ASSOCIATION OF CORONARY RISK FACTORS WITH PROXIMAL AND DISTAL ATHEROSCLEROSIS Journal of the American College of Cardiology. 55: A128.E1194. DOI: 10.1016/S0735-1097(10)61195-3  0.304
2010 Dunbar RL, Gadi R, Baer A, Goel H, Baber A, Rehan M, Rader DJ, Millar J. FENOFIBRIC AND NICOTINIC ACID PROGRESSIVELY SUPPRESS POSTPRANDIAL TRIGLYCERIDEMIA IN STATIN-TREATED PATIENTS WITH LOW HIGH-DENSITY LIPOPROTEIN CHOLESTEROL Journal of the American College of Cardiology. 55: A47.E447. DOI: 10.1016/S0735-1097(10)60448-2  0.387
2010 Dunbar RL, Gadi R, Baer A, Gupta A, Javed A, Lord C, Rader DJ, Millar J. TRIPLE THERAPY WITH STATIN, FIBRATE (TRILIPIX) AND NIACIN RAISES HIGH-DENSITY LIPOPROTEIN CHOLESTEROL WITHOUT CHANGING APOLIPOPROTEIN A-I LEVELS Journal of the American College of Cardiology. 55: A47.E446. DOI: 10.1016/S0735-1097(10)60447-0  0.411
2010 Kathiresan S, Rader DJ. Lipoprotein Disorders Essentials of Genomic and Personalized Medicine. 269-288. DOI: 10.1016/B978-0-12-374934-5.00023-4  0.335
2009 Khera AV, Rader DJ. Discovery and Validation of New Molecular Targets in Treating Dyslipidemia: The Role of Human Genetics Trends in Cardiovascular Medicine. 19: 195-201. PMID 20211435 DOI: 10.1016/J.Tcm.2009.12.003  0.386
2009 Richards JB, Waterworth D, O'Rahilly S, Hivert MF, Loos RJ, Perry JR, Tanaka T, Timpson NJ, Semple RK, Soranzo N, Song K, Rocha N, Grundberg E, Dupuis J, Florez JC, ... ... Rader DJ, et al. A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. Plos Genetics. 5: e1000768. PMID 20011104 DOI: 10.1371/Journal.Pgen.1000768  0.327
2009 Soranzo N, Spector TD, Mangino M, Kühnel B, Rendon A, Teumer A, Willenborg C, Wright B, Chen L, Li M, Salo P, Voight BF, Burns P, Laskowski RA, Xue Y, ... ... Rader DJ, et al. A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nature Genetics. 41: 1182-90. PMID 19820697 DOI: 10.1038/Ng.467  0.316
2009 Alexander ET, Weibel GL, Joshi MR, Vedhachalam C, de la Llera-Moya M, Rothblat GH, Phillips MC, Rader DJ. Macrophage reverse cholesterol transport in mice expressing ApoA-I Milano. Arteriosclerosis, Thrombosis, and Vascular Biology. 29: 1496-501. PMID 19661486 DOI: 10.1161/Atvbaha.109.191379  0.353
2009 Stylianou IM, Svenson KL, VanOrman SK, Langle Y, Millar JS, Paigen B, Rader DJ. Novel ENU-induced point mutation in scavenger receptor class B, member 1, results in liver specific loss of SCARB1 protein. Plos One. 4: e6521. PMID 19654867 DOI: 10.1371/Journal.Pone.0006521  0.417
2009 Rader DJ. Lecithin: Cholesterol acyltransferase and atherosclerosis: Another high-density lipoprotein story that doesn't quite follow the script Circulation. 120: 549-552. PMID 19652089 DOI: 10.1161/Circulationaha.109.881979  0.457
2009 Heffron SP, Parastatidis I, Cuchel M, Wolfe ML, Tadesse MG, Mohler ER, Ischiropoulos H, Rader DJ, Reilly MP. Inflammation induces fibrinogen nitration in experimental human endotoxemia. Free Radical Biology & Medicine. 47: 1140-6. PMID 19631267 DOI: 10.1016/J.Freeradbiomed.2009.07.025  0.447
2009 Nishimoto T, Pellizzon MA, Aihara M, Stylianou IM, Billheimer JT, Rothblat G, Rader DJ. Fish oil promotes macrophage reverse cholesterol transport in mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 29: 1502-8. PMID 19574561 DOI: 10.1161/Atvbaha.109.187252  0.321
2009 Griffon N, Jin W, Petty TJ, Millar J, Badellino KO, Saven JG, Marchadier DH, Kempner ES, Billheimer J, Glick JM, Rader DJ. Identification of the active form of endothelial lipase, a homodimer in a head-to-tail conformation. The Journal of Biological Chemistry. 284: 23322-30. PMID 19567873 DOI: 10.1074/Jbc.M109.037002  0.351
2009 Tanigawa H, Billheimer JT, Tohyama J, Fuki IV, Ng DS, Rothblat GH, Rader DJ. Lecithin: cholesterol acyltransferase expression has minimal effects on macrophage reverse cholesterol transport in vivo. Circulation. 120: 160-9. PMID 19564558 DOI: 10.1161/Circulationaha.108.825109  0.428
2009 Zhao L, Jin W, Rader D, Packard C, Feuerstein G. A Translational Medicine perspective of the development of torcetrapib: Does the failure of torcetrapib development cast a shadow on future development of lipid modifying agents, HDL elevation strategies or CETP as a viable molecular target for atherosclerosis? A case study of the use of biomarkers and Translational Medicine in atherosclerosis drug discovery and development. Biochemical Pharmacology. 78: 315-325. PMID 19539799 DOI: 10.1016/J.Bcp.2009.03.014  0.395
2009 Becker DJ, Gordon RY, Halbert SC, French B, Morris PB, Rader DJ. Red yeast rice for dyslipidemia in statin-intolerant patients: a randomized trial. Annals of Internal Medicine. 150: 830-9, W147-9. PMID 19528562 DOI: 10.7326/0003-4819-150-12-200906160-00006  0.417
2009 Duffy D, Rader DJ. Update on strategies to increase HDL quantity and function Nature Reviews. Cardiology. 6: 455-463. PMID 19488077 DOI: 10.1038/Nrcardio.2009.94  0.441
2009 Brown RJ, Edmondson AC, Griffon N, Hill TB, Fuki IV, Badellino KO, Li M, Wolfe ML, Reilly MP, Rader DJ. A naturally occurring variant of endothelial lipase associated with elevated HDL exhibits impaired synthesis. Journal of Lipid Research. 50: 1910-6. PMID 19411705 DOI: 10.1194/Jlr.P900020-Jlr200  0.693
2009 Jensen MK, Rimm EB, Mukamal KJ, Edmondson AC, Rader DJ, Vogel U, Tjønneland A, Sørensen TI, Schmidt EB, Overvad K. The T111I variant in the endothelial lipase gene and risk of coronary heart disease in three independent populations. European Heart Journal. 30: 1584-9. PMID 19411665 DOI: 10.1093/Eurheartj/Ehp145  0.683
2009 Alexander ET, Tanaka M, Kono M, Saito H, Rader DJ, Phillips MC. Structural and functional consequences of the Milano mutation (R173C) in human apolipoprotein A-I. Journal of Lipid Research. 50: 1409-19. PMID 19318685 DOI: 10.1194/Jlr.M800578-Jlr200  0.348
2009 Edmondson AC, Brown RJ, Kathiresan S, Cupples LA, Demissie S, Manning AK, Jensen MK, Rimm EB, Wang J, Rodrigues A, Bamba V, Khetarpal SA, Wolfe ML, Derohannessian S, Li M, ... ... Rader DJ, et al. Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans. The Journal of Clinical Investigation. 119: 1042-50. PMID 19287092 DOI: 10.1172/Jci37176  0.695
2009 Brousseau ME, Millar JS, Diffenderfer MR, Nartsupha C, Asztalos BF, Wolfe ML, Mancuso JP, Digenio AG, Rader DJ, Schaefer EJ. Effects of cholesteryl ester transfer protein inhibition on apolipoprotein A-II-containing HDL subspecies and apolipoprotein A-II metabolism. Journal of Lipid Research. 50: 1456-62. PMID 19193611 DOI: 10.1194/Jlr.P800037-Jlr200  0.329
2009 Neeli H, Gadi R, Rader DJ. Managing diabetic dyslipidemia: Beyond statin therapy Current Diabetes Reports. 9: 11-17. PMID 19192419 DOI: 10.1007/S11892-009-0004-Y  0.417
2009 Movva R, Rader DJ. [Laboratory assessment of HDL heterogeneity and function]. Annales De Biologie Clinique. 67: 7-21. PMID 19189882 DOI: 10.1684/abc.2008.0284  0.304
2009 Jensen MK, Rimm EB, Rader D, Schmidt EB, Sørensen TI, Vogel U, Overvad K, Mukamal KJ. S447X variant of the lipoprotein lipase gene, lipids, and risk of coronary heart disease in 3 prospective cohort studies. American Heart Journal. 157: 384-90. PMID 19185650 DOI: 10.1016/J.Ahj.2008.10.008  0.469
2009 Rader DJ, Alexander ET, Weibel GL, Billheimer J, Rothblat GH. The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis. Journal of Lipid Research. 50: S189-94. PMID 19064999 DOI: 10.1194/Jlr.R800088-Jlr200  0.451
2009 Mohler ER, Shi Y, Moore J, Bantly A, Hamamdzic D, Yoder M, Rader DJ, Putt M, Zhang L, Parmacek M, Wilensky RL. Diabetes reduces bone marrow and circulating porcine endothelial progenitor cells, an effect ameliorated by atorvastatin and independent of cholesterol. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 75: 75-82. PMID 19051240 DOI: 10.1002/Cyto.A.20691  0.304
2009 Lagor WR, Brown RJ, Toh SA, Millar JS, Fuki IV, de la Llera-Moya M, Yuen T, Rothblat G, Billheimer JT, Rader DJ. Overexpression of apolipoprotein F reduces HDL cholesterol levels in vivo. Arteriosclerosis, Thrombosis, and Vascular Biology. 29: 40-6. PMID 19008531 DOI: 10.1161/Atvbaha.108.177105  0.404
2009 Tohyama J, Billheimer JT, Fuki IV, Rothblat GH, Rader DJ, Millar JS. Effects of nevirapine and efavirenz on HDL cholesterol levels and reverse cholesterol transport in mice. Atherosclerosis. 204: 418-23. PMID 18990393 DOI: 10.1016/J.Atherosclerosis.2008.09.016  0.434
2009 Qasim AN, Metkus TS, Tadesse M, Lehrke M, Restine S, Wolfe ML, Hannenhalli S, Cappola T, Rader DJ, Reilly MP. Resistin gene variation is associated with systemic inflammation but not plasma adipokine levels, metabolic syndrome or coronary atherosclerosis in nondiabetic Caucasians. Clinical Endocrinology. 70: 698-705. PMID 18710472 DOI: 10.1111/J.1365-2265.2008.03375.X  0.36
2009 Meagher E, Davidson M, Rosen M, Robinson J, Bays H, Bloedon L, Sasiela W, Parris M, Rader D. Abstract: 103 EFFECTS OF LOW DOSE MTP INHIBITION ALONE AND IN COMBINATION WITH OTHER LIPID-LOWERING DRUGS ON HEPATIC FAT AND PLASMA LIPIDS Atherosclerosis Supplements. 10: e228. DOI: 10.1016/S1567-5688(09)70232-6  0.353
2009 Dunbar RL, Gadi R, Nathanson G, Gourineni V, Rader DJ, Goel H, Nayyer S, Lily S. A Single Dose of Extended-Release Niacin Suppresses Postprandial Triglyceridemia in Healthy Volunteers Journal of Clinical Lipidology. 3: 210. DOI: 10.1016/J.Jacl.2009.04.005  0.364
2008 Edmondson AC, Rader DJ. Genome-wide approaches to finding novel genes for lipid traits: the start of a long road. Circulation. Cardiovascular Genetics. 1: 3-6. PMID 20031536 DOI: 10.1161/Circgenetics.108.815530  0.707
2008 Kolansky DM, Cuchel M, Clark BJ, Paridon S, McCrindle BW, Wiegers SE, Araujo L, Vohra Y, Defesche JC, Wilson JM, Rader DJ. Longitudinal evaluation and assessment of cardiovascular disease in patients with homozygous familial hypercholesterolemia. The American Journal of Cardiology. 102: 1438-43. PMID 19026292 DOI: 10.1016/J.Amjcard.2008.07.035  0.349
2008 Keating BJ, Tischfield S, Murray SS, Bhangale T, Price TS, Glessner JT, Galver L, Barrett JC, Grant SF, Farlow DN, Chandrupatla HR, Hansen M, Ajmal S, Papanicolaou GJ, Guo Y, ... ... Rader DJ, et al. Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. Plos One. 3: e3583. PMID 18974833 DOI: 10.1371/Journal.Pone.0003583  0.652
2008 Neeli H, Rader DJ. Cholesteryl Ester Transfer Protein (CETP) Inhibitors: Is There Life After Torcetrapib? Cardiology Clinics. 26: 537-546. PMID 18929230 DOI: 10.1016/J.Ccl.2008.06.005  0.424
2008 Toh SA, Rader DJ. Dyslipidemia in insulin resistance: Clinical challenges and adipocentric therapeutic frontiers Expert Review of Cardiovascular Therapy. 6: 1007-1022. PMID 18666851 DOI: 10.1586/14779072.6.7.1007  0.309
2008 Brown RJ, Rader DJ. When HDL gets fat.. Circulation Research. 103: 131-132. PMID 18635830 DOI: 10.1161/Circresaha.108.180638  0.445
2008 deGoma EM, deGoma RL, Rader DJ. Beyond High-Density Lipoprotein Cholesterol Levels: Evaluating High-Density Lipoprotein Function as Influenced by Novel Therapeutic Approaches Journal of the American College of Cardiology. 51: 2199-2211. PMID 18534265 DOI: 10.1016/J.Jacc.2008.03.016  0.409
2008 Samaha FF, McKenney J, Bloedon LT, Sasiela WJ, Rader DJ. Inhibition of microsomal triglyceride transfer protein alone or with ezetimibe in patients with moderate hypercholesterolemia. Nature Clinical Practice. Cardiovascular Medicine. 5: 497-505. PMID 18506154 DOI: 10.1038/Ncpcardio1250  0.437
2008 Ky B, Burke A, Tsimikas S, Wolfe ML, Tadesse MG, Szapary PO, Witztum JL, FitzGerald GA, Rader DJ. The influence of pravastatin and atorvastatin on markers of oxidative stress in hypercholesterolemic humans. Journal of the American College of Cardiology. 51: 1653-62. PMID 18436117 DOI: 10.1016/J.Jacc.2008.01.026  0.36
2008 Movva R, Rader DJ. Laboratory assessment of HDL heterogeneity and function. Clinical Chemistry. 54: 788-800. PMID 18375481 DOI: 10.1373/Clinchem.2007.101923  0.419
2008 Bloedon LT, Dunbar R, Duffy D, Pinell-Salles P, Norris R, DeGroot BJ, Movva R, Navab M, Fogelman AM, Rader DJ. Safety, pharmacokinetics, and pharmacodynamics of oral apoA-I mimetic peptide D-4F in high-risk cardiovascular patients. Journal of Lipid Research. 49: 1344-52. PMID 18323573 DOI: 10.1194/Jlr.P800003-Jlr200  0.3
2008 Rader DJ, Daugherty A. Translating molecular discoveries into new therapies for atherosclerosis Nature. 451: 904-913. PMID 18288179 DOI: 10.1038/Nature06796  0.366
2008 Liu Y, Millar JS, Cromley DA, Graham M, Crooke R, Billheimer JT, Rader DJ. Knockdown of acyl-CoA:diacylglycerol acyltransferase 2 with antisense oligonucleotide reduces VLDL TG and ApoB secretion in mice. Biochimica Et Biophysica Acta. 1781: 97-104. PMID 18252207 DOI: 10.1016/J.Bbalip.2008.01.001  0.337
2008 Badellino KO, Wolfe ML, Reilly MP, Rader DJ. Endothelial lipase is increased in vivo by inflammation in humans. Circulation. 117: 678-85. PMID 18212282 DOI: 10.1161/Circulationaha.107.707349  0.405
2008 Millar JS, Brousseau ME, Diffenderfer MR, Barrett PH, Welty FK, Cohn JS, Wilson A, Wolfe ML, Nartsupha C, Schaefer PM, Digenio AG, Mancuso JP, Dolnikowski GG, Schaefer EJ, Rader DJ. Effects of the cholesteryl ester transfer protein inhibitor torcetrapib on VLDL apolipoprotein E metabolism. Journal of Lipid Research. 49: 543-9. PMID 18033754 DOI: 10.1194/Jlr.M700268-Jlr200  0.365
2008 Glassberg H, Rader DJ. Management of lipids in the prevention of cardiovascular events Annual Review of Medicine. 59: 79-94. PMID 17937591 DOI: 10.1146/Annurev.Med.59.121206.112237  0.402
2008 Marais AD, Raal FJ, Stein EA, Rader DJ, Blasetto J, Palmer M, Wilpshaar W. A dose-titration and comparative study of rosuvastatin and atorvastatin in patients with homozygous familial hypercholesterolaemia. Atherosclerosis. 197: 400-6. PMID 17727860 DOI: 10.1016/J.Atherosclerosis.2007.06.028  0.34
2008 Ali K, Lund-Katz S, Lawson J, Phillips MC, Rader DJ. Structure-function properties of the apoE-dependent COX-2 pathway in vascular smooth muscle cells. Atherosclerosis. 196: 201-9. PMID 17531997 DOI: 10.1016/J.Atherosclerosis.2007.03.038  0.341
2007 Rader DJ. Liver X Receptor and Farnesoid X Receptor as Therapeutic Targets American Journal of Cardiology. 100. PMID 18047847 DOI: 10.1016/J.Amjcard.2007.08.008  0.365
2007 Lilly SM, Rader DJ. New targets and emerging therapies for reducing LDL cholesterol Current Opinion in Lipidology. 18: 650-655. PMID 17993811 DOI: 10.1097/Mol.0B013E3282F169C6  0.453
2007 Rader DJ. Illuminating HDL - Is it still a viable therapeutic target? New England Journal of Medicine. 357: 2180-2183. PMID 17984168 DOI: 10.1056/Nejme0707210  0.474
2007 Adorni MP, Zimetti F, Billheimer JT, Wang N, Rader DJ, Phillips MC, Rothblat GH. The roles of different pathways in the release of cholesterol from macrophages. Journal of Lipid Research. 48: 2453-62. PMID 17761631 DOI: 10.1194/Jlr.M700274-Jlr200  0.412
2007 Tanigawa H, Billheimer JT, Tohyama J, Zhang Y, Rothblat G, Rader DJ. Expression of cholesteryl ester transfer protein in mice promotes macrophage reverse cholesterol transport. Circulation. 116: 1267-73. PMID 17709636 DOI: 10.1161/Circulationaha.107.704254  0.406
2007 Jin W, Wang X, Millar JS, Quertermous T, Rothblat GH, Glick JM, Rader DJ. Hepatic proprotein convertases modulate HDL metabolism. Cell Metabolism. 6: 129-36. PMID 17681148 DOI: 10.1016/J.Cmet.2007.07.009  0.442
2007 Wang X, Collins HL, Ranalletta M, Fuki IV, Billheimer JT, Rothblat GH, Tall AR, Rader DJ. Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo. The Journal of Clinical Investigation. 117: 2216-24. PMID 17657311 DOI: 10.1172/Jci32057  0.312
2007 Weibel GL, Alexander ET, Joshi MR, Rader DJ, Lund-Katz S, Phillips MC, Rothblat GH. Wild-type ApoA-I and the Milano variant have similar abilities to stimulate cellular lipid mobilization and efflux. Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 2022-9. PMID 17615385 DOI: 10.1161/Atvbaha.107.148403  0.408
2007 Parastatidis I, Thomson L, Fries DM, Moore RE, Tohyama J, Fu X, Hazen SL, Heijnen HF, Dennehy MK, Liebler DC, Rader DJ, Ischiropoulos H. Increased protein nitration burden in the atherosclerotic lesions and plasma of apolipoprotein A-I deficient mice. Circulation Research. 101: 368-76. PMID 17615369 DOI: 10.1161/Circresaha.107.157537  0.342
2007 Wang X, Rader DJ. Molecular regulation of macrophage reverse cholesterol transport Current Opinion in Cardiology. 22: 368-372. PMID 17556891 DOI: 10.1097/Hco.0B013E3281Ec5113  0.343
2007 Skropeta D, Settasatian C, McMahon MR, Shearston K, Caiazza D, McGrath KC, Jin W, Rader DJ, Barter PJ, Rye KA. N-Glycosylation regulates endothelial lipase-mediated phospholipid hydrolysis in apoE- and apoA-I-containing high density lipoproteins Journal of Lipid Research. 48: 2047-2057. PMID 17545692 DOI: 10.1194/Jlr.M700248-Jlr200  0.313
2007 Bamba V, Rader DJ. Obesity and Atherogenic Dyslipidemia Gastroenterology. 132: 2181-2190. PMID 17498511 DOI: 10.1053/J.Gastro.2007.03.056  0.372
2007 Helgadottir A, Thorleifsson G, Manolescu A, Gretarsdottir S, Blondal T, Jonasdottir A, Jonasdottir A, Sigurdsson A, Baker A, Palsson A, Masson G, Gudbjartsson DF, Magnusson KP, Andersen K, Levey AI, ... ... Rader DJ, et al. A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science (New York, N.Y.). 316: 1491-3. PMID 17478679 DOI: 10.1126/Science.1142842  0.302
2007 Lebherz C, Sanmiguel J, Wilson JM, Rader DJ. Gene transfer of wild-type apoA-I and apoA-I Milano reduce atherosclerosis to a similar extent. Cardiovascular Diabetology. 6: 15. PMID 17475009 DOI: 10.1186/1475-2840-6-15  0.314
2007 Steinthorsdottir V, Thorleifsson G, Reynisdottir I, Benediktsson R, Jonsdottir T, Walters GB, Styrkarsdottir U, Gretarsdottir S, Emilsson V, Ghosh S, Baker A, Snorradottir S, Bjarnason H, Ng MCY, Hansen T, ... ... Rader DJ, et al. A variant in CDKAL1 influences insulin response and risk of type 2 diabetes Nature Genetics. 39: 770-775. PMID 17460697 DOI: 10.1038/Ng2043  0.305
2007 Pellizzon MA, Billheimer JT, Bloedon LT, Szapary PO, Rader DJ. Flaxseed reduces plasma cholesterol levels in hypercholesterolemic mouse models. Journal of the American College of Nutrition. 26: 66-75. PMID 17353585 DOI: 10.1080/07315724.2007.10719587  0.392
2007 Brown RJ, Miller GC, Griffon N, Long CJ, Rader DJ. Glycosylation of endothelial lipase at asparagine-116 reduces activity and the hydrolysis of native lipoproteins in vitro and in vivo. Journal of Lipid Research. 48: 1132-9. PMID 17322565 DOI: 10.1194/Jlr.M600535-Jlr200  0.403
2007 Rader DJ. Effect of Insulin Resistance, Dyslipidemia, and Intra-abdominal Adiposity on the Development of Cardiovascular Disease and Diabetes Mellitus American Journal of Medicine. 120. PMID 17320517 DOI: 10.1016/J.Amjmed.2007.01.003  0.312
2007 Lehrke M, Millington SC, Lefterova M, Cumaranatunge RG, Szapary P, Wilensky R, Rader DJ, Lazar MA, Reilly MP. CXCL16 is a marker of inflammation, atherosclerosis, and acute coronary syndromes in humans. Journal of the American College of Cardiology. 49: 442-9. PMID 17258089 DOI: 10.1016/J.Jacc.2006.09.034  0.358
2007 Rader DJ. Mechanisms of Disease: HDL metabolism as a target for novel therapies Nature Clinical Practice Cardiovascular Medicine. 4: 102-109. PMID 17245404 DOI: 10.1038/Ncpcardio0768  0.464
2007 Cuchel M, Bloedon LT, Szapary PO, Kolansky DM, Wolfe ML, Sarkis A, Millar JS, Ikewaki K, Siegelman ES, Gregg RE, Rader DJ. Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia New England Journal of Medicine. 356: 148-156. PMID 17215532 DOI: 10.1056/Nejmoa061189  0.41
2007 Qasim A, Rader DJ. Human genetics of variation in high-density lipoprotein cholesterol. Current Atherosclerosis Reports. 8: 198-205. PMID 16767843 DOI: 10.1007/S11883-006-0074-0  0.473
2007 Sachais BS, Tur-Rentine T, Mckenna JMD, Rux AH, Rader D, Kowalska MA. Elimination of platelet factor 4 (PF4) from platelets reduces atherosclerosis in C57Bl/6 and apoE-/- mice. Thrombosis and Haemostasis. 98: 1108-1113. DOI: 10.1160/Th07-04-0271  0.335
2006 Rader DJ. Molecular regulation of HDL metabolism and function: Implications for novel therapies Journal of Clinical Investigation. 116: 3090-3100. PMID 17143322 DOI: 10.1172/Jci30163  0.419
2006 Broedl UC, Jin W, Fuki IV, Millar JS, Rader DJ. Endothelial lipase is less effective at influencing HDL metabolism in vivo in mice expressing apoA-II. Journal of Lipid Research. 47: 2191-7. PMID 16877778 DOI: 10.1194/Jlr.M600036-Jlr200  0.384
2006 Millar JS, Stone SJ, Tietge UJ, Tow B, Billheimer JT, Wong JS, Hamilton RL, Farese RV, Rader DJ. Short-term overexpression of DGAT1 or DGAT2 increases hepatic triglyceride but not VLDL triglyceride or apoB production. Journal of Lipid Research. 47: 2297-305. PMID 16877777 DOI: 10.1194/Jlr.M600213-Jlr200  0.344
2006 Paradis ME, Badellino KO, Rader DJ, Tchernof A, Richard C, Luu-The V, Deshaies Y, Bergeron J, Archer WR, Couture P, Bergeron N, Lamarche B. Visceral adiposity and endothelial lipase. The Journal of Clinical Endocrinology and Metabolism. 91: 3538-43. PMID 16772345 DOI: 10.1210/Jc.2006-0766  0.408
2006 Kitajima K, Marchadier DH, Miller GC, Gao GP, Wilson JM, Rader DJ. Complete prevention of atherosclerosis in apoE-deficient mice by hepatic human apoE gene transfer with adeno-associated virus serotypes 7 and 8. Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 1852-7. PMID 16763161 DOI: 10.1161/01.Atv.0000231520.26490.54  0.349
2006 Cuchel M, Rader DJ. Macrophage reverse cholesterol transport: Key to the regression of atherosclerosis? Circulation. 113: 2548-2555. PMID 16735689 DOI: 10.1161/Circulationaha.104.475715  0.454
2006 Reilly M, Rader DJ. Apolipoprotein E and coronary disease: A puzzling paradox Plos Medicine. 3: 0736-0738. PMID 16729847 DOI: 10.1371/Journal.Pmed.0030258  0.437
2006 Griffon N, Budreck EC, Long CJ, Broedl UC, Marchadier DH, Glick JM, Rader DJ. Substrate specificity of lipoprotein lipase and endothelial lipase: studies of lid chimeras. Journal of Lipid Research. 47: 1803-11. PMID 16682746 DOI: 10.1194/Jlr.M500552-Jlr200  0.31
2006 Duffy D, Rader DJ. High-density lipoprotein cholesterol therapies: The next frontier in lipid management Journal of Cardiopulmonary Rehabilitation. 26: 1-8. PMID 16617219 DOI: 10.1097/00008483-200601000-00001  0.431
2006 Millar JS, Brousseau ME, Diffenderfer MR, Barrett PH, Welty FK, Faruqi A, Wolfe ML, Nartsupha C, Digenio AG, Mancuso JP, Dolnikowski GG, Schaefer EJ, Rader DJ. Effects of the cholesteryl ester transfer protein inhibitor torcetrapib on apolipoprotein B100 metabolism in humans. Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 1350-6. PMID 16574893 DOI: 10.1161/01.Atv.0000219695.84644.56  0.439
2006 Duffy D, Rader DJ. Emerging therapies targeting high-density lipoprotein metabolism and reverse cholesterol transport Circulation. 113: 1140-1150. PMID 16505192 DOI: 10.1161/Circulationaha.105.593855  0.448
2006 Majdalawieh A, Zhang L, Fuki IV, Rader DJ, Ro HS. Adipocyte enhancer-binding protein 1 is a potential novel atherogenic factor involved in macrophage cholesterol homeostasis and inflammation. Proceedings of the National Academy of Sciences of the United States of America. 103: 2346-51. PMID 16461908 DOI: 10.1073/Pnas.0508139103  0.366
2006 Ahmed W, Orasanu G, Nehra V, Asatryan L, Rader DJ, Ziouzenkova O, Plutzky J. High-density lipoprotein hydrolysis by endothelial lipase activates PPARalpha: a candidate mechanism for high-density lipoprotein-mediated repression of leukocyte adhesion. Circulation Research. 98: 490-8. PMID 16439686 DOI: 10.1161/01.Res.0000205846.46812.Be  0.385
2006 Naik SU, Wang X, Da Silva JS, Jaye M, Macphee CH, Reilly MP, Billheimer JT, Rothblat GH, Rader DJ. Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo. Circulation. 113: 90-7. PMID 16365197 DOI: 10.1161/Circulationaha.105.560177  0.405
2006 Samaha FF, Szapary PO, Iqbal N, Williams MM, Bloedon LT, Kochar A, Wolfe ML, Rader DJ. Effects of rosiglitazone on lipids, adipokines, and inflammatory markers in nondiabetic patients with low high-density lipoprotein cholesterol and metabolic syndrome Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 624-630. PMID 16357312 DOI: 10.1161/01.Atv.0000200136.56716.30  0.406
2006 Badellino KO, Wolfe ML, Reilly MP, Rader DJ. Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis Plos Medicine. 3: 0245-0252. PMID 16354105 DOI: 10.1371/Journal.Pmed.0030022  0.383
2006 Seetharam D, Mineo C, Gormley AK, Gibson LL, Vongpatanasin W, Chambliss KL, Hahner LD, Cummings ML, Kitchens RL, Marcel YL, Rader DJ, Shaul PW. High-density lipoprotein promotes endothelial cell migration and reendothelialization via scavenger receptor-B type I. Circulation Research. 98: 63-72. PMID 16339487 DOI: 10.1161/01.Res.0000199272.59432.5B  0.361
2006 Szapary PO, Bloedon LT, Samaha FF, Duffy D, Wolfe ML, Soffer D, Reilly MP, Chittams J, Rader DJ. Effects of pioglitazone on lipoproteins, inflammatory markers, and adipokines in nondiabetic patients with metabolic syndrome. Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 182-8. PMID 16284192 DOI: 10.1161/01.Atv.0000195790.24531.4F  0.368
2006 Sachais BS, Katz J, Ross J, Rader DJ. Long-term effects of LDL apheresis in patients with severe hypercholesterolemia. Journal of Clinical Apheresis. 20: 252-5. PMID 15880364 DOI: 10.1002/Jca.20036  0.452
2006 Sachais BS, Turrentine T, Dawicki-McKenna JM, Rader DJ, Kowalska MA. Elimination of Platelet Factor 4 (PF4) from Platelets Reduces Atherosclerosis and Increases HDL Cholesterol in C57Bl/6 and ApoE−/− Mice. Blood. 108: 418-418. DOI: 10.1182/Blood.V108.11.418.418  0.338
2006 Cuchel M, Bloedon L, Kolansky D, Szapary P, Wolfe M, Millar J, Ikewaki K, Siegelman E, Gregg R, Rader D. Th-P16:322 Microsomial transfer protein (MTP) inhibition substantially reduces cholesterol in patients with homozygous familial hypercholesterolemia Atherosclerosis Supplements. 7: 564. DOI: 10.1016/S1567-5688(06)82280-4  0.327
2006 Fuki I, Chang D, Faruqi A, Cromley D, Billheimer J, Wang X, Jaye M, Rothblat G, Rader D. Th-P15:214 Characterization of bone marrow-derived macrophages for studies of cholesterol efflux in vitro and reverse cholesterol transport in vivo Atherosclerosis Supplements. 7: 540. DOI: 10.1016/S1567-5688(06)82173-2  0.342
2006 Brousseau M, Diffenderfer M, Millar J, Nartsupha C, Asztalos B, Welty F, Wolfe M, Mancuso J, Digenio A, Rader D, Schaefer E. Mo-W1:1 Effects of cholesteryl ester transfer protein inhibition on lipoprotein metabolism in humans Atherosclerosis Supplements. 7: 11. DOI: 10.1016/S1567-5688(06)80023-1  0.324
2005 Li Z, Qiao H, Lebherz C, Choi SR, Zhou X, Gao G, Kung HF, Rader DJ, Wilson JM, Glickson JD, Zhou R. Creatine kinase, a magnetic resonance-detectable marker gene for quantification of liver-directed gene transfer. Human Gene Therapy. 16: 1429-38. PMID 16390274 DOI: 10.1089/Hum.2005.16.1429  0.305
2005 Raggi P, Taylor A, Fayad Z, O’Leary D, Nissen S, Rader D, Shaw LJ. Atherosclerotic plaque imaging: contemporary role in preventive cardiology. Jama Internal Medicine. 165: 2345-2353. PMID 16287763 DOI: 10.1001/Archinte.165.20.2345  0.318
2005 Zhang Y, Da Silva JR, Reilly M, Billheimer JT, Rothblat GH, Rader DJ. Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivo. The Journal of Clinical Investigation. 115: 2870-4. PMID 16200214 DOI: 10.1172/Jci25327  0.398
2005 Rader DJ. Gain-of-function mutations and therapeutic implications: Lipoprotein lipase S447X to the rescue Arteriosclerosis, Thrombosis, and Vascular Biology. 25: 2018-2019. PMID 16199757 DOI: 10.1161/01.Atv.0000183606.81315.85  0.343
2005 Ali K, Middleton M, Puré E, Rader DJ. Apolipoprotein E suppresses the type I inflammatory response in vivo. Circulation Research. 97: 922-7. PMID 16179587 DOI: 10.1161/01.Res.0000187467.67684.43  0.32
2005 Moore RE, Navab M, Millar JS, Zimetti F, Hama S, Rothblat GH, Rader DJ. Increased atherosclerosis in mice lacking apolipoprotein A-I attributable to both impaired reverse cholesterol transport and increased inflammation. Circulation Research. 97: 763-71. PMID 16151025 DOI: 10.1161/01.Res.0000185320.82962.F7  0.429
2005 Cain WJ, Millar JS, Himebauch AS, Tietge UJ, Maugeais C, Usher D, Rader DJ. Lipoprotein [a] is cleared from the plasma primarily by the liver in a process mediated by apolipoprotein [a]. Journal of Lipid Research. 46: 2681-91. PMID 16150825 DOI: 10.1194/Jlr.M500249-Jlr200  0.339
2005 Dunbar RL, Rader DJ. Demystifying triglycerides: A practical approach for the clinician Cleveland Clinic Journal of Medicine. 72: 661-680. PMID 16122052 DOI: 10.3949/Ccjm.72.8.661  0.349
2005 Jin W, Fuki IV, Seidah NG, Benjannet S, Glick JM, Rader DJ. Proprotein convertases [corrected] are responsible for proteolysis and inactivation of endothelial lipase. The Journal of Biological Chemistry. 280: 36551-9. PMID 16109723 DOI: 10.1074/Jbc.M502264200  0.333
2005 Kitajima K, Marchadier DH, Burstein H, Rader DJ. Persistent liver expression of murine apoA-l using vectors based on adeno-associated viral vectors serotypes 5 and 1. Atherosclerosis. 186: 65-73. PMID 16099465 DOI: 10.1016/J.Atherosclerosis.2005.07.009  0.324
2005 Lehrke M, Lebherz C, Millington SC, Guan HP, Millar J, Rader DJ, Wilson JM, Lazar MA. Diet-dependent cardiovascular lipid metabolism controlled by hepatic LXRalpha. Cell Metabolism. 1: 297-308. PMID 16054077 DOI: 10.1016/J.Cmet.2005.04.005  0.418
2005 Rader DJ, Puré E. Lipoproteins, macrophage function, and atherosclerosis: Beyond the foam cell? Cell Metabolism. 1: 223-230. PMID 16054067 DOI: 10.1016/J.Cmet.2005.03.005  0.402
2005 Broedl UC, Rader DJ. Gene therapy for lipoprotein disorders Expert Opinion On Biological Therapy. 5: 1029-1038. PMID 16050781 DOI: 10.1517/14712598.5.8.1029  0.372
2005 Millar JS, Cromley DA, McCoy MG, Rader DJ, Billheimer JT. Determining hepatic triglyceride production in mice: comparison of poloxamer 407 with Triton WR-1339. Journal of Lipid Research. 46: 2023-8. PMID 15995182 DOI: 10.1194/Jlr.D500019-Jlr200  0.393
2005 Lewis GF, Rader DJ. New insights into the regulation of HDL metabolism and reverse cholesterol transport. Circulation Research. 96: 1221-32. PMID 15976321 DOI: 10.1161/01.Res.0000170946.56981.5C  0.467
2005 Reilly MP, Foulkes AS, Wolfe ML, Rader DJ. Higher order lipase gene association with plasma triglycerides. Journal of Lipid Research. 46: 1914-22. PMID 15961789 DOI: 10.1194/Jlr.M500042-Jlr200  0.362
2005 Duffy D, Rader DJ. Drugs in development: Targeting high-density lipoprotein metabolism and reverse cholesterol transport Current Opinion in Cardiology. 20: 301-306. PMID 15956827 DOI: 10.1097/01.Hco.0000168532.69342.26  0.431
2005 Sovic A, Panzenboeck U, Wintersperger A, Kratzer I, Hammer A, Levak-Frank S, Frank S, Rader DJ, Malle E, Sattler W. Regulated expression of endothelial lipase by porcine brain capillary endothelial cells constituting the blood-brain barrier. Journal of Neurochemistry. 94: 109-19. PMID 15953354 DOI: 10.1111/J.1471-4159.2005.03175.X  0.358
2005 Taylor A, Shaw LJ, Fayad Z, O'Leary D, Brown BG, Nissen S, Rader D, Raggi P. Tracking atherosclerosis regression: a clinical tool in preventive cardiology. Atherosclerosis. 180: 1-10. PMID 15823269 DOI: 10.1016/J.Atherosclerosis.2004.12.024  0.316
2005 Brousseau ME, Diffenderfer MR, Millar JS, Nartsupha C, Asztalos BF, Welty FK, Wolfe ML, Rudling M, Björkhem I, Angelin B, Mancuso JP, Digenio AG, Rader DJ, Schaefer EJ. Effects of cholesteryl ester transfer protein inhibition on high-density lipoprotein subspecies, apolipoprotein A-I metabolism, and fecal sterol excretion. Arteriosclerosis, Thrombosis, and Vascular Biology. 25: 1057-64. PMID 15761191 DOI: 10.1161/01.Atv.0000161928.16334.Dd  0.445
2005 Ky B, Rader DJ. The effects of statin therapy on plasma markers of inflammation in patients without vascular disease Clinical Cardiology. 28: 67-70. PMID 15757075 DOI: 10.1002/Clc.4960280204  0.385
2005 Rader DJ. ATVB in focus novel approaches to the treatment of dyslipidemia Arteriosclerosis, Thrombosis, and Vascular Biology. 25: 480-481. PMID 15731488 DOI: 10.1161/01.Atv.0000154483.28595.A3  0.463
2005 Bastone L, Reilly M, Rader DJ, Foulkes AS. MDR and PRP: a comparison of methods for high-order genotype-phenotype associations. Human Heredity. 58: 82-92. PMID 15711088 DOI: 10.1159/000083029  0.314
2005 Reilly MP, Lehrke M, Wolfe ML, Rohatgi A, Lazar MA, Rader DJ. Resistin is an inflammatory marker of atherosclerosis in humans. Circulation. 111: 932-9. PMID 15710760 DOI: 10.1161/01.Cir.0000155620.10387.43  0.376
2005 Millar JS, Maugeais C, Ikewaki K, Kolansky DM, Barrett PH, Budreck EC, Boston RC, Tada N, Mochizuki S, Defesche JC, Wilson JM, Rader DJ. Complete deficiency of the low-density lipoprotein receptor is associated with increased apolipoprotein B-100 production. Arteriosclerosis, Thrombosis, and Vascular Biology. 25: 560-5. PMID 15637307 DOI: 10.1161/01.Atv.0000155323.18856.A2  0.41
2005 Kratky D, Zimmermann R, Wagner EM, Strauss JG, Jin W, Kostner GM, Haemmerle G, Rader DJ, Zechner R. Endothelial lipase provides an alternative pathway for FFA uptake in lipoprotein lipase-deficient mouse adipose tissue. The Journal of Clinical Investigation. 115: 161-7. PMID 15630456 DOI: 10.1172/Jci15972  0.366
2005 Anderson PD, Mehta NN, Wolfe ML, McMahon K, Hinkle C, Comiskey L, Tabita-Martinez J, Sellers K, Ahima RS, Rader DJ, Reilly MP. 9 ADIPOKINES IN HUMAN ENDOTOXEMIA Journal of Investigative Medicine. 53: S388.3-S388. DOI: 10.2310/6650.2005.00205.8  0.303
2005 Egan KM, Lawson JA, Fries S, Koller B, Rader DJ, Smyth EM, FitzGerald GA. Cyclooxygenase-2-Derived Prostacyclin Confers Atheroprotection on Female Mice Obstetrical & Gynecological Survey. 60: 309-310. DOI: 10.1097/01.Ogx.0000160574.33752.4F  0.346
2005 Moores R, Navab M, Hama S, Zimetti F, Rothblat G, Rader D. W09-P-012 ApoA-I is required for HDL anti-atherogenic function in vivo Atherosclerosis Supplements. 6: 42. DOI: 10.1016/S1567-5688(05)80168-0  0.323
2005 Dunbar RL, Rader DJ. Current drug options for raising HDL cholesterol Current Treatment Options in Cardiovascular Medicine. 7: 15-23. DOI: 10.1007/S11936-005-0002-6  0.403
2004 Reilly MP, Wolfe ML, Dykhouse J, Reddy K, Localio AR, Rader DJ. Intercellular adhesion molecule 1 (ICAM-1) gene variant is associated with coronary artery calcification independent of soluble ICAM-1 levels Journal of Investigative Medicine. 52: 515-522. PMID 15682683 DOI: 10.1136/Jim-52-08-23  0.368
2004 Broedl UC, Jin W, Fuki IV, Glick JM, Rader DJ. Structural basis of endothelial lipase tropism for HDL. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1891-3. PMID 15456739 DOI: 10.1096/Fj.03-1307Fje  0.395
2004 Seshadri P, Iqbal N, Stern L, Williams M, Chicano KL, Daily DA, McGrory J, Gracely EJ, Rader DJ, Samaha FF. A randomized study comparing the effects of a low-carbohydrate diet and a conventional diet on lipoprotein subfractions and C-reactive protein levels in patients with severe obesity. The American Journal of Medicine. 117: 398-405. PMID 15380496 DOI: 10.1016/J.Amjmed.2004.04.009  0.309
2004 Wolfe ML, Rader DJ. Cholesteryl ester transfer protein and coronary artery disease: An observation with therapeutic implications Circulation. 110: 1338-1340. PMID 15364817 DOI: 10.1161/01.Cir.0000143047.52724.Bb  0.488
2004 Caiazza D, Jahangiri A, Rader DJ, Marchadier D, Rye KA. Apolipoproteins regulate the kinetics of endothelial lipase-mediated hydrolysis of phospholipids in reconstituted high-density lipoproteins Biochemistry. 43: 11898-11905. PMID 15362876 DOI: 10.1021/Bi049776T  0.33
2004 Benjannet S, Rhainds D, Essalmani R, Mayne J, Wickham L, Jin W, Asselin MC, Hamelin J, Varret M, Allard D, Trillard M, Abifadel M, Tebon A, Attie AD, Rader DJ, et al. NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol. The Journal of Biological Chemistry. 279: 48865-75. PMID 15358785 DOI: 10.1074/Jbc.M409699200  0.425
2004 Zhao L, Moos MP, Gräbner R, Pédrono F, Fan J, Kaiser B, John N, Schmidt S, Spanbroek R, Lötzer K, Huang L, Cui J, Rader DJ, Evans JF, Habenicht AJ, et al. The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm. Nature Medicine. 10: 966-73. PMID 15322539 DOI: 10.1038/Nm1099  0.327
2004 Szapary PO, Rader DJ. The triglyceride-high-density lipoprotein axis: An important target of therapy? American Heart Journal. 148: 211-221. PMID 15308990 DOI: 10.1016/J.Ahj.2004.03.037  0.477
2004 Rader DJ. Inhibition of cholesteryl ester transfer protein activity: A new therapeutic approach to raising high-density lipoprotein Current Atherosclerosis Reports. 6: 398-405. PMID 15296707 DOI: 10.1007/S11883-004-0052-3  0.469
2004 Reilly MP, Iqbal N, Schutta M, Wolfe ML, Scally M, Localio AR, Rader DJ, Kimmel SE. Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetes. The Journal of Clinical Endocrinology and Metabolism. 89: 3872-8. PMID 15292320 DOI: 10.1210/Jc.2003-031676  0.334
2004 Reilly MP, Wolfe ML, Rhodes T, Girman C, Mehta N, Rader DJ. Measures of insulin resistance add incremental value to the clinical diagnosis of metabolic syndrome in association with coronary atherosclerosis. Circulation. 110: 803-9. PMID 15289378 DOI: 10.1161/01.Cir.0000138740.84883.9C  0.312
2004 Broedl UC, Jin W, Rader DJ. Endothelial lipase: A modulator of lipoprotein metabolism upregulated by inflammation Trends in Cardiovascular Medicine. 14: 202-206. PMID 15261893 DOI: 10.1016/J.Tcm.2004.03.003  0.399
2004 Badellino KO, Rader DJ. The role of endothelial lipase in high-density lipoprotein metabolism Current Opinion in Cardiology. 19: 392-395. PMID 15218402 DOI: 10.1097/01.Hco.0000130161.89169.02  0.443
2004 Reilly MP, Wolfe ML, Localio AR, Rader DJ. Coronary artery calcification and cardiovascular risk factors: Impact of the analytic approach Atherosclerosis. 173: 69-78. PMID 15177125 DOI: 10.1016/J.Atherosclerosis.2003.10.010  0.305
2004 Lebherz C, Gao G, Louboutin JP, Millar J, Rader D, Wilson JM. Gene therapy with novel adeno-associated virus vectors substantially diminishes atherosclerosis in a murine model of familial hypercholesterolemia. The Journal of Gene Medicine. 6: 663-72. PMID 15170737 DOI: 10.1002/Jgm.554  0.385
2004 Broedl UC, Maugeais C, Millar JS, Jin W, Moore RE, Fuki IV, Marchadier D, Glick JM, Rader DJ. Endothelial lipase promotes the catabolism of ApoB-containing lipoproteins. Circulation Research. 94: 1554-61. PMID 15117821 DOI: 10.1161/01.Res.0000130657.00222.39  0.468
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