Xianxin Hua - Publications

Cell and Molecular Biology University of Pennsylvania, Philadelphia, PA, United States 
Cell Biology, Oncology

36 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Ma J, He X, Cao Y, O'dwyer K, Szigety KM, Wu Y, Gurung B, Feng Z, Kanota BW, Hua X. Islet-Specific Prmt5 Excision Leads to Reduced Insulin Expression and Glucose Intolerance in Mice. The Journal of Endocrinology. PMID 31539871 DOI: 10.1530/JOE-19-0268  0.4
2019 Wu Y, Doepner M, Hojnacki T, Feng Z, Katona BW, He X, Ma J, Cao Y, Busino L, Zhou F, Hua X. Disruption of the menin-MLL interaction triggers menin protein degradation via ubiquitin-proteasome pathway. American Journal of Cancer Research. 9: 1682-1694. PMID 31497350  0.4
2019 Katona BW, Glynn RA, Paulosky KE, Feng Z, Davis CI, Ma J, Berry CT, Szigety KM, Matkar S, Liu Y, Wang H, Wu Y, He X, Freedman BD, Brady DC, ... Hua X, et al. Combined menin and EGFR inhibitors synergize to suppress colorectal cancer via EGFR-independent and calcium-mediated repression of SKP2 transcription. Cancer Research. PMID 30877106 DOI: 10.1158/0008-5472.CAN-18-2133  0.4
2019 Xing B, Ma J, Jiang Z, Feng Z, Ling S, Szigety K, Su W, Zhang L, Jia R, Sun Y, Zhang L, Kong X, Ma X, Hua X. GLP-1 signaling suppresses menin's transcriptional block by phosphorylation in β cells. The Journal of Cell Biology. PMID 30792230 DOI: 10.1083/jcb.201805049  0.4
2019 Jiang Z, Xing B, Feng Z, Ma J, Ma X, Hua X. Menin Upregulates FOXO1 Protein Stability by Repressing Skp2-Mediated Degradation in β Cells. Pancreas. PMID 30629029 DOI: 10.1097/MPA.0000000000001239  0.4
2017 Feng Z, Ma J, Hua X. Epigenetic regulation by the menin pathway. Endocrine-Related Cancer. PMID 28811300 DOI: 10.1530/ERC-17-0298  0.4
2016 Feng Z, Wang L, Sun Y, Jiang Z, Domsic J, An C, Xing B, Tian J, Liu X, Metz DC, Yang X, Marmorstein R, Ma X, Hua X. Menin and Daxx Interact to Control Neuroendocrine Tumors via Epigenetic Regulation of Membrane Metallo-Endopeptidase. Cancer Research. PMID 27872097 DOI: 10.1158/0008-5472.CAN-16-1567  0.4
2014 Matkar S, Katona BW, Hua X. Harnessing the hidden antitumor power of the MLL-AF4 oncogene to fight leukemia. Cancer Cell. 25: 411-3. PMID 24735921 DOI: 10.1016/j.ccr.2014.03.028  0.88
2014 Gurung B, Muhammad AB, Hua X. Menin is required for optimal processing of the microRNA let-7a. The Journal of Biological Chemistry. 289: 9902-8. PMID 24563463 DOI: 10.1074/jbc.M113.520692  0.88
2013 Gurung B, Hua X. Menin/PRMT5/hedgehog signaling: a potential target for the treatment of multiple endocrine neoplasia type 1 tumors. Epigenomics. 5: 469-71. PMID 24059791 DOI: 10.2217/epi.13.47  0.88
2013 Gurung B, Feng Z, Hua X. Menin directly represses Gli1 expression independent of canonical Hedgehog signaling. Molecular Cancer Research : McR. 11: 1215-22. PMID 23928057 DOI: 10.1158/1541-7786.MCR-13-0170  0.88
2013 Gurung B, Feng Z, Iwamoto DV, Thiel A, Jin G, Fan CM, Ng JM, Curran T, Hua X. Menin epigenetically represses Hedgehog signaling in MEN1 tumor syndrome. Cancer Research. 73: 2650-8. PMID 23580576 DOI: 10.1158/0008-5472.CAN-12-3158  0.88
2013 Thiel AT, Feng Z, Pant DK, Chodosh LA, Hua X. The trithorax protein partner menin acts in tandem with EZH2 to suppress C/EBPα and differentiation in MLL-AF9 leukemia. Haematologica. 98: 918-27. PMID 23349306 DOI: 10.3324/haematol.2012.074195  0.88
2012 Thiel AT, Huang J, Lei M, Hua X. Menin as a hub controlling mixed lineage leukemia Bioessays. 34: 771-780. PMID 22829075 DOI: 10.1002/bies.201200007  0.88
2012 Huang J, Gurung B, Wan B, Matkar S, Veniaminova NA, Wan K, Merchant JL, Hua X, Lei M. The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature. 482: 542-6. PMID 22327296 DOI: 10.1038/nature10806  0.88
2010 Yang Y, Gurung B, Wu T, Wang H, Stoffers DA, Hua X. Reversal of preexisting hyperglycemia in diabetic mice by acute deletion of the Men1 gene. Proceedings of the National Academy of Sciences of the United States of America. 107: 20358-63. PMID 21059956 DOI: 10.1073/pnas.1012257107  0.88
2010 Aggarwal P, Vaites LP, Kim JK, Mellert H, Gurung B, Nakagawa H, Herlyn M, Hua X, Rustgi AK, McMahon SB, Diehl JA. Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase. Cancer Cell. 18: 329-40. PMID 20951943 DOI: 10.1016/j.ccr.2010.08.012  0.88
2010 Thiel AT, Blessington P, Zou T, Feather D, Wu X, Yan J, Zhang H, Liu Z, Ernst P, Koretzky GA, Hua X. MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele. Cancer Cell. 17: 148-59. PMID 20159607 DOI: 10.1016/j.ccr.2009.12.034  0.88
2009 Maillard I, Chen YX, Friedman A, Yang Y, Tubbs AT, Shestova O, Pear WS, Hua X. Menin regulates the function of hematopoietic stem cells and lymphoid progenitors. Blood. 113: 1661-9. PMID 19228930 DOI: 10.1182/blood-2009-01-135012  0.88
2008 Wu X, Hua X. Menin, histone h3 methyltransferases, and regulation of cell proliferation: current knowledge and perspective. Current Molecular Medicine. 8: 805-15. PMID 19075677 DOI: 10.2174/156652408786733702  0.88
2007 La P, Yang Y, Karnik SK, Silva AC, Schnepp RW, Kim SK, Hua X. Menin-mediated caspase 8 expression in suppressing multiple endocrine neoplasia type 1. The Journal of Biological Chemistry. 282: 31332-40. PMID 17766243 DOI: 10.1074/jbc.M609555200  0.88
2007 Wu XJ, Hua X. Targeting ROS: selective killing of cancer cells by a cruciferous vegetable derived pro-oxidant compound. Cancer Biology & Therapy. 6: 646-7. PMID 17387274  0.88
2007 Yang Y, Hua X. In search of tumor suppressing functions of menin. Molecular and Cellular Endocrinology. 265: 34-41. PMID 17222504 DOI: 10.1016/j.mce.2006.12.032  0.88
2006 Yan J, Chen YX, Desmond A, Silva A, Yang Y, Wang H, Hua X. Cdx4 and menin co-regulate Hoxa9 expression in hematopoietic cells. Plos One. 1: e47. PMID 17183676 DOI: 10.1371/journal.pone.0000047  0.32
2006 Schnepp RW, Chen YX, Wang H, Cash T, Silva A, Diehl JA, Brown E, Hua X. Mutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cells. Cancer Research. 66: 5707-15. PMID 16740708 DOI: 10.1158/0008-5472.CAN-05-4518  0.88
2006 La P, Desmond A, Hou Z, Silva AC, Schnepp RW, Hua X. Tumor suppressor menin: the essential role of nuclear localization signal domains in coordinating gene expression. Oncogene. 25: 3537-46. PMID 16449969 DOI: 10.1038/sj.onc.1209400  0.88
2006 Chen YX, Yan J, Keeshan K, Tubbs AT, Wang H, Silva A, Brown EJ, Hess JL, Pear WS, Hua X. The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression. Proceedings of the National Academy of Sciences of the United States of America. 103: 1018-23. PMID 16415155 DOI: 10.1073/pnas.0510347103  0.88
2005 Milne TA, Hughes CM, Lloyd R, Yang Z, Rozenblatt-Rosen O, Dou Y, Schnepp RW, Krankel C, Livolsi VA, Gibbs D, Hua X, Roeder RG, Meyerson M, Hess JL. Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 102: 749-54. PMID 15640349 DOI: 10.1073/pnas.0408836102  0.88
2004 Schnepp RW, Hou Z, Wang H, Petersen C, Silva A, Masai H, Hua X. Functional interaction between tumor suppressor menin and activator of S-phase kinase. Cancer Research. 64: 6791-6. PMID 15374998 DOI: 10.1158/0008-5472.CAN-04-0724  0.88
2004 La P, Silva AC, Hou Z, Wang H, Schnepp RW, Yan N, Shi Y, Hua X. Direct binding of DNA by tumor suppressor menin. The Journal of Biological Chemistry. 279: 49045-54. PMID 15331604 DOI: 10.1074/jbc.M409358200  0.88
2004 La P, Schnepp RW, D Petersen C, C Silva A, Hua X. Tumor suppressor menin regulates expression of insulin-like growth factor binding protein 2. Endocrinology. 145: 3443-50. PMID 15044367 DOI: 10.1210/en.2004-0124  0.88
2004 Schnepp RW, Mao H, Sykes SM, Zong WX, Silva A, La P, Hua X. Menin induces apoptosis in murine embryonic fibroblasts. The Journal of Biological Chemistry. 279: 10685-91. PMID 14688275 DOI: 10.1074/jbc.M308073200  0.88
2003 Jin S, Mao H, Schnepp RW, Sykes SM, Silva AC, D'Andrea AD, Hua X. Menin associates with FANCD2, a protein involved in repair of DNA damage. Cancer Research. 63: 4204-10. PMID 12874027  0.88
2003 Schnepp R, Hua X. A tumor-suppressing duo: TGFbeta and activin modulate a similar transcriptome. Cancer Biology & Therapy. 2: 171-2. PMID 12750557 DOI: 10.4161/cbt.2.2.280  0.88
2003 La P, Morgan TA, Sykes SM, Mao H, Schnepp RW, Petersen CD, Hua X. Fusion proteins of retinoid receptors antagonize TGF-beta-induced growth inhibition of lung epithelial cells. Oncogene. 22: 198-210. PMID 12527889 DOI: 10.1038/sj.onc.1206100  0.88
2001 Hua X, Thompson CB. Quiescent T cells: Actively maintaining inactivity Nature Immunology. 2: 1097-1098. PMID 11725297 DOI: 10.1038/ni1201-1097  0.88
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