Christopher R. Vakoc, Ph.D. - Publications

2008- Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 
Molecular Biology

51 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Lan X, Khandros E, Huang P, Peslak SA, Bhardwaj SK, Grevet JD, Abdulmalik O, Wang H, Keller CA, Giardine B, Baeza J, Duffner ER, El Demerdash O, Wu XS, Vakoc CR, et al. The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells. Blood Advances. 3: 1586-1597. PMID 31126914 DOI: 10.1182/Bloodadvances.2019032318  0.92
2019 Bharathy N, Berlow NE, Wang E, Abraham J, Settelmeyer TP, Hooper JE, Svalina MN, Bajwa Z, Goros MW, Hernandez BS, Wolff JE, Pal R, Davies AM, Ashok A, Bushby D, ... ... Vakoc CR, et al. Preclinical rationale for entinostat in embryonal rhabdomyosarcoma. Skeletal Muscle. 9: 12. PMID 31113472 DOI: 10.1186/S13395-019-0198-X  0.4
2018 Bharathy N, Berlow NE, Wang E, Abraham J, Settelmeyer TP, Hooper JE, Svalina MN, Ishikawa Y, Zientek K, Bajwa Z, Goros MW, Hernandez BS, Wolff JE, Rudek MA, Xu L, ... ... Vakoc CR, et al. The HDAC3-SMARCA4-miR-27a axis promotes expression of the fusion oncogene in rhabdomyosarcoma. Science Signaling. 11. PMID 30459282 DOI: 10.1126/Scisignal.Aau7632  0.4
2018 Skucha A, Ebner J, Schmöllerl J, Roth M, Eder T, César-Razquin A, Stukalov A, Vittori S, Muhar M, Lu B, Aichinger M, Jude J, Müller AC, Győrffy B, Vakoc CR, et al. MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity. Nature Communications. 9: 1983. PMID 29777171 DOI: 10.1038/S41467-018-04329-Y  0.4
2016 Hohmann AF, Martin LJ, Minder JL, Roe JS, Shi J, Steurer S, Bader G, McConnell D, Pearson M, Gerstberger T, Gottschamel T, Thompson D, Suzuki Y, Koegl M, Vakoc CR. Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibition. Nature Chemical Biology. PMID 27376689 DOI: 10.1038/Nchembio.2115  0.76
2016 Bhagwat AS, Roe JS, Mok BY, Hohmann AF, Shi J, Vakoc CR. BET Bromodomain Inhibition Releases the Mediator Complex from Select cis-Regulatory Elements. Cell Reports. PMID 27068464 DOI: 10.1016/J.Celrep.2016.03.054  0.76
2016 Martin LJ, Koegl M, Bader G, Cockcroft XL, Fedorov O, Fiegen D, Gerstberger T, Hofmann MH, Hohmann AF, Kessler D, Knapp S, Knesl P, Kornigg S, Müller S, Nar H, ... ... Vakoc CR, et al. Structure-based design of an in vivo active selective BRD9 inhibitor. Journal of Medicinal Chemistry. PMID 26914985 DOI: 10.1021/Acs.Jmedchem.5B01865  0.76
2015 Bhagwat AS, Vakoc CR. Targeting Transcription Factors in Cancer. Trends in Cancer. 1: 53-65. PMID 26645049 DOI: 10.1016/J.Trecan.2015.07.001  0.76
2015 Shen C, Ipsaro JJ, Shi J, Milazzo JP, Wang E, Roe JS, Suzuki Y, Pappin DJ, Joshua-Tor L, Vakoc CR. NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler. Molecular Cell. PMID 26626481 DOI: 10.1016/J.Molcel.2015.10.033  0.76
2015 Matthews GM, Mehdipour P, Cluse LA, Falkenberg KJ, Wang E, Roth M, Santoro F, Vidacs E, Stanley K, House CM, Rusche JR, Vakoc CR, Zuber J, Minucci S, Johnstone RW. Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies. Blood. PMID 26447190 DOI: 10.1182/Blood-2015-03-632984  0.76
2015 Rathert P, Roth M, Neumann T, Muerdter F, Roe JS, Muhar M, Deswal S, Cerny-Reiterer S, Peter B, Jude J, Hoffmann T, Boryń ŁM, Axelsson E, Schweifer N, Tontsch-Grunt U, ... ... Vakoc CR, et al. Transcriptional plasticity promotes primary and acquired resistance to BET inhibition. Nature. 525: 543-7. PMID 26367798 DOI: 10.1038/Nature14898  0.76
2015 Shi J, Wang E, Milazzo JP, Wang Z, Kinney JB, Vakoc CR. Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains. Nature Biotechnology. 33: 661-7. PMID 25961408 DOI: 10.1038/Nbt.3235  0.76
2015 Wang E, Kawaoka S, Roe JS, Shi J, Hohmann AF, Xu Y, Bhagwat AS, Suzuki Y, Kinney JB, Vakoc CR. The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer. Elife. 4: e06377. PMID 25919951 DOI: 10.7554/Elife.06377  0.76
2015 Yu JR, Tai Y, Jin Y, Hammell MC, Wilkinson JE, Roe JS, Vakoc CR, Van Aelst L. TGF-β/Smad signaling through DOCK4 facilitates lung adenocarcinoma metastasis. Genes & Development. 29: 250-61. PMID 25644601 DOI: 10.1101/Gad.248963.114  0.76
2015 Shen C, Vakoc CR. Gain-of-function mutation of chromatin regulators as a tumorigenic mechanism and an opportunity for therapeutic intervention. Current Opinion in Oncology. 27: 57-63. PMID 25402979 DOI: 10.1097/Cco.0000000000000151  0.76
2015 Wang E, Kawaoka S, Roe J, Shi J, Hohmann AF, Xu Y, Bhagwat AS, Suzuki Y, Kinney JB, Vakoc CR. Author response: The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer Elife. DOI: 10.7554/Elife.06377.022  0.4
2015 Roe JS, Mercan F, Rivera K, Pappin DJ, Vakoc CR. BET Bromodomain Inhibition Suppresses the Function of Hematopoietic Transcription Factors in Acute Myeloid Leukemia Molecular Cell. 58: 1028-1039. DOI: 10.1016/j.molcel.2015.04.011  0.76
2015 Vakoc CR. BET bromodomain inhibition as a therapeutic approach in hematological malignancies Histone Recognition. 185-198. DOI: 10.1007/978-3-319-18102-8_9  0.76
2014 Xu Y, Vakoc CR. Brd4 is on the move during inflammation. Trends in Cell Biology. 24: 615-6. PMID 25288306 DOI: 10.1016/J.Tcb.2014.09.005  0.76
2014 Hohmann AF, Vakoc CR. A rationale to target the SWI/SNF complex for cancer therapy. Trends in Genetics : Tig. 30: 356-63. PMID 24932742 DOI: 10.1016/J.Tig.2014.05.001  0.76
2014 Mazurek A, Park Y, Miething C, Wilkinson JE, Gillis J, Lowe SW, Vakoc CR, Stillman B. Acquired dependence of acute myeloid leukemia on the DEAD-box RNA helicase DDX5. Cell Reports. 7: 1887-99. PMID 24910429 DOI: 10.1016/J.Celrep.2014.05.019  0.76
2014 Shi J, Vakoc CR. The mechanisms behind the therapeutic activity of BET bromodomain inhibition. Molecular Cell. 54: 728-36. PMID 24905006 DOI: 10.1016/J.Molcel.2014.05.016  0.76
2014 Chen C, Liu Y, Rappaport AR, Kitzing T, Schultz N, Zhao Z, Shroff AS, Dickins RA, Vakoc CR, Bradner JE, Stock W, LeBeau MM, Shannon KM, Kogan S, Zuber J, et al. MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia Cancer Cell. 25: 652-665. PMID 24794707 DOI: 10.1016/J.Ccr.2014.03.016  0.76
2014 Bhagwat AS, Vakoc CR. A new bump in the epigenetic landscape. Molecular Cell. 53: 857-8. PMID 24656126 DOI: 10.1016/J.Molcel.2014.03.001  0.76
2014 Roe JS, Vakoc CR. C/EBPα: critical at the origin of leukemic transformation. The Journal of Experimental Medicine. 211: 1-4. PMID 24395889 DOI: 10.1084/Jem.20132530  0.76
2013 Shi J, Whyte WA, Zepeda-Mendoza CJ, Milazzo JP, Shen C, Roe JS, Minder JL, Mercan F, Wang E, Eckersley-Maslin MA, Campbell AE, Kawaoka S, Shareef S, Zhu Z, Kendall J, ... ... Vakoc CR, et al. Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation. Genes & Development. 27: 2648-62. PMID 24285714 DOI: 10.1101/Gad.232710.113  0.76
2013 Roe JS, Vakoc CR. Oncogene interference through targeting of chromatin regulators. Cell Cycle (Georgetown, Tex.). 12: 1475-6. PMID 23624838 DOI: 10.4161/Cc.24748  0.76
2013 Lovén J, Hoke HA, Lin CY, Lau A, Orlando DA, Vakoc CR, Bradner JE, Lee TI, Young RA. Selective inhibition of tumor oncogenes by disruption of super-enhancers. Cell. 153: 320-34. PMID 23582323 DOI: 10.1016/J.Cell.2013.03.036  0.76
2013 Wang E, Kawaoka S, Yu M, Shi J, Ni T, Yang W, Zhu J, Roeder RG, Vakoc CR. Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia. Proceedings of the National Academy of Sciences of the United States of America. 110: 3901-6. PMID 23412334 DOI: 10.1073/Pnas.1301045110  0.76
2013 Shi J, Wang E, Zuber J, Rappaport A, Taylor M, Johns C, Lowe SW, Vakoc CR. The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras G12D acute myeloid leukemia Oncogene. 32: 930-938. PMID 22469984 DOI: 10.1038/Onc.2012.110  0.76
2012 Herrmann H, Blatt K, Shi J, Gleixner KV, Cerny-Reiterer S, Müllauer L, Vakoc CR, Sperr WR, Horny HP, Bradner JE, Zuber J, Valent P. Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia (AML) Oncotarget. 3: 1588-1599. PMID 23249862 DOI: 10.18632/Oncotarget.733  0.76
2012 Ernst P, Vakoc CR. WRAD: enabler of the SET1-family of H3K4 methyltransferases. Briefings in Functional Genomics. 11: 217-26. PMID 22652693 DOI: 10.1093/Bfgp/Els017  0.76
2011 Delmore JE, Issa GC, Lemieux ME, Rahl PB, Shi J, Jacobs HM, Kastritis E, Gilpatrick T, Paranal RM, Qi J, Chesi M, Schinzel AC, McKeown MR, Heffernan TP, Vakoc CR, et al. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell. 146: 904-17. PMID 21889194 DOI: 10.1016/J.Cell.2011.08.017  0.76
2011 Zuber J, Rappaport AR, Luo W, Wang E, Chen C, Vaseva AV, Shi J, Weissmueller S, Fellmann C, Fellman C, Taylor MJ, Weissenboeck M, Graeber TG, Kogan SC, Vakoc CR, et al. An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance. Genes & Development. 25: 1628-40. PMID 21828272 DOI: 10.1101/Gad.17269211  0.76
2011 Zuber J, Shi J, Wang E, Rappaport AR, Herrmann H, Sison EA, Magoon D, Qi J, Blatt K, Wunderlich M, Taylor MJ, Johns C, Chicas A, Mulloy JC, Kogan SC, ... ... Vakoc CR, et al. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature. 478: 524-8. PMID 21814200 DOI: 10.1038/Nature10334  0.76
2010 Speck NA, Vakoc CR. PAF is in the cabal of MLL1-interacting proteins that promote leukemia. Cancer Cell. 17: 531-2. PMID 20541697 DOI: 10.1016/J.Ccr.2010.05.019  0.76
2009 Blobel GA, Kadauke S, Wang E, Lau AW, Zuber J, Chou MM, Vakoc CR. A reconfigured pattern of MLL occupancy within mitotic chromatin promotes rapid transcriptional reactivation following mitotic exit. Molecular Cell. 36: 970-83. PMID 20064463 DOI: 10.1016/J.Molcel.2009.12.001  0.76
2009 Chou ST, Khandros E, Bailey LC, Nichols KE, Vakoc CR, Yao Y, Huang Z, Crispino JD, Hardison RC, Blobel GA, Weiss MJ. Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate. Blood. 114: 983-94. PMID 19491391 DOI: 10.1182/Blood-2009-03-207944  0.76
2009 Vakoc CR, Wen YY, Gibbs RA, Johnstone CN, Rustgi AK, Blobel GA. Low frequency of MLL3 mutations in colorectal carcinoma. Cancer Genetics and Cytogenetics. 189: 140-1. PMID 19215798 DOI: 10.1016/J.Cancergencyto.2008.10.014  0.76
2009 Tripic T, Deng W, Cheng Y, Zhang Y, Vakoc CR, Gregory GD, Hardison RC, Blobel GA. SCL and associated proteins distinguish active from repressive GATA transcription factor complexes. Blood. 113: 2191-201. PMID 19011221 DOI: 10.1182/Blood-2008-07-169417  0.76
2008 Steger DJ, Lefterova MI, Ying L, Stonestrom AJ, Schupp M, Zhuo D, Vakoc AL, Kim JE, Chen J, Lazar MA, Blobel GA, Vakoc CR. DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. Molecular and Cellular Biology. 28: 2825-39. PMID 18285465 DOI: 10.1128/Mcb.02076-07  0.76
2008 Jing H, Vakoc CR, Ying L, Mandat S, Wang H, Zheng X, Blobel GA. Exchange of GATA factors mediates transitions in looped chromatin organization at a developmentally regulated gene locus. Molecular Cell. 29: 232-42. PMID 18243117 DOI: 10.1016/J.Molcel.2007.11.020  0.76
2007 Gregory GD, Vakoc CR, Rozovskaia T, Zheng X, Patel S, Nakamura T, Canaani E, Blobel GA. Mammalian ASH1L is a histone methyltransferase that occupies the transcribed region of active genes. Molecular and Cellular Biology. 27: 8466-79. PMID 17923682 DOI: 10.1128/Mcb.00993-07  0.76
2006 Zeng PY, Vakoc CR, Chen ZC, Blobel GA, Berger SL. In vivo dual cross-linking for identification of indirect DNA-associated proteins by chromatin immunoprecipitation. Biotechniques. 41: 694, 696, 698. PMID 17191611 DOI: 10.2144/000112297  0.76
2006 Vakoc CR, Sachdeva MM, Wang H, Blobel GA. Profile of histone lysine methylation across transcribed mammalian chromatin. Molecular and Cellular Biology. 26: 9185-95. PMID 17030614 DOI: 10.1128/Mcb.01529-06  0.76
2006 Lamonica JM, Vakoc CR, Blobel GA. Acetylation of GATA-1 is required for chromatin occupancy. Blood. 108: 3736-8. PMID 16888089 DOI: 10.1182/Blood-2006-07-032847  0.76
2005 Vakoc CR, Mandat SA, Olenchock BA, Blobel GA. Histone H3 lysine 9 methylation and HP1gamma are associated with transcription elongation through mammalian chromatin. Molecular Cell. 19: 381-91. PMID 16061184 DOI: 10.1016/J.Molcel.2005.06.011  0.76
2005 Hong W, Nakazawa M, Chen YY, Kori R, Vakoc CR, Rakowski C, Blobel GA. FOG-1 recruits the NuRD repressor complex to mediate transcriptional repression by GATA-1. The Embo Journal. 24: 2367-78. PMID 15920470 DOI: 10.1038/Sj.Emboj.7600703  0.76
2005 Vakoc CR, Letting DL, Gheldof N, Sawado T, Bender MA, Groudine M, Weiss MJ, Dekker J, Blobel GA. Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1. Molecular Cell. 17: 453-62. PMID 15694345 DOI: 10.1016/J.Molcel.2004.12.028  0.76
2005 Vakoc CR, Mandat SA, Olenschock BA, Blobel GA. Histone H3 Lysine 9 Methylation and HP1γ Are Associated with Transcription Elongation through Mammalian Chromatin. Blood. 106: 1734-1734. DOI: 10.1182/Blood.V106.11.1734.1734  0.92
2004 Welch JJ, Watts JA, Vakoc CR, Yao Y, Wang H, Hardison RC, Blobel GA, Chodosh LA, Weiss MJ. Global regulation of erythroid gene expression by transcription factor GATA-1. Blood. 104: 3136-47. PMID 15297311 DOI: 10.1182/Blood-2004-04-1603  0.76
Show low-probability matches.