| Year |
Citation |
Score |
| 2024 |
Duplaquet L, So K, Ying AW, Pal Choudhuri S, Li X, Xu GD, Li Y, Qiu X, Li R, Singh S, Wu XS, Hamilton S, Chien VD, Liu Q, Qi J, ... ... Vakoc CR, et al. Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer. Cancer Cell. PMID 39029464 DOI: 10.1016/j.ccell.2024.06.012 |
0.38 |
|
| 2024 |
He T, Xiao L, Qiao Y, Klingbeil O, Young E, Wu XS, Mannan R, Mahapatra S, Redin E, Cho H, Bao Y, Kandarpa M, Ching-Yi Tien J, Wang X, Eyunni S, ... ... Vakoc CR, et al. Targeting the mSWI/SNF complex in POU2F-POU2AF transcription factor-driven malignancies. Cancer Cell. PMID 39029462 DOI: 10.1016/j.ccell.2024.06.006 |
0.365 |
|
| 2024 |
Maia-Silva D, Cunniff PJ, Schier AC, Skopelitis D, Trousdell MC, Moresco P, Gao Y, Kechejian V, He XY, Sahin Y, Wan L, Alpsoy A, Liverpool J, Krainer AR, Egeblad M, ... ... Vakoc CR, et al. Interaction between MED12 and ΔNp63 activates basal identity in pancreatic ductal adenocarcinoma. Nature Genetics. PMID 38886586 DOI: 10.1038/s41588-024-01790-y |
0.329 |
|
| 2024 |
Gao Y, Vakoc CR. Therapeutic index of targeting select chromatin complexes in human cancer patients. Current Opinion in Genetics & Development. 85: 102162. PMID 38401489 DOI: 10.1016/j.gde.2024.102162 |
0.345 |
|
| 2024 |
He T, Xiao L, Qiao Y, Klingbeil O, Young E, Wu XS, Mannan R, Mahapatra S, Eyunni S, Tien JC, Wang X, Zheng Y, Kim N, Zheng H, Hou S, ... ... Vakoc CR, et al. Targeting the mSWI/SNF Complex in POU2F-POU2AF Transcription Factor-Driven Malignancies. Biorxiv : the Preprint Server For Biology. PMID 38328238 DOI: 10.1101/2024.01.22.576669 |
0.347 |
|
| 2024 |
Duplaquet L, So K, Ying AW, Li X, Li Y, Qiu X, Li R, Singh S, Wu XS, Liu Q, Qi J, Somerville TDD, Heiling H, Mazzola E, Lee Y, ... ... Vakoc CR, et al. Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer. Biorxiv : the Preprint Server For Biology. PMID 38328215 DOI: 10.1101/2024.01.21.576304 |
0.376 |
|
| 2024 |
Alpsoy A, Wu XS, Pal S, Klingbeil O, Kumar P, El Demerdash O, Nalbant B, Vakoc CR. IκBζ is a dual-use coactivator of NF-κB and POU transcription factors. Molecular Cell. PMID 38309274 DOI: 10.1016/j.molcel.2024.01.007 |
0.362 |
|
| 2023 |
Xu J, Roe JS, Lee E, Tonelli C, Ji KY, Younis OW, Somervile TDD, Yao M, Milazzo JP, Tiriac H, Kolarzyk AM, Lee E, Grem JL, Lazenby AJ, Grunkemeyer JA, ... ... Vakoc CR, et al. Engrailed-1 Promotes Pancreatic Cancer Metastasis. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). e2308537. PMID 38110836 DOI: 10.1002/advs.202308537 |
0.393 |
|
| 2023 |
Pomella S, Cassandri M, D'Archivio L, Porrazzo A, Cossetti C, Phelps D, Perrone C, Pezzella M, Cardinale A, Wachtel M, Aloisi S, Milewski D, Colletti M, Sreenivas P, Walters ZS, ... ... Vakoc CR, et al. MYOD-SKP2 axis boosts tumorigenesis in fusion negative rhabdomyosarcoma by preventing differentiation through p57 targeting. Nature Communications. 14: 8373. PMID 38102140 DOI: 10.1038/s41467-023-44130-0 |
0.35 |
|
| 2023 |
Maia-Silva D, Schier AC, Skopelitis D, Kechejian V, Alpsoy A, Liverpool J, Taatjes DJ, Vakoc CR. Marker-based CRISPR screening reveals a MED12-p63 interaction that activates basal identity in pancreatic ductal adenocarcinoma. Biorxiv : the Preprint Server For Biology. PMID 37961243 DOI: 10.1101/2023.10.24.563848 |
0.306 |
|
| 2023 |
Sroka MW, Skopelitis D, Vermunt MW, Preall JB, El Demerdash O, de Almeida LMN, Chang K, Utama R, Gryder B, Caligiuri G, Ren D, Nalbant B, Milazzo JP, Tuveson DA, Dobin A, ... ... Vakoc CR, et al. Myo-differentiation reporter screen reveals NF-Y as an activator of PAX3-FOXO1 in rhabdomyosarcoma. Proceedings of the National Academy of Sciences of the United States of America. 120: e2303859120. PMID 37639593 DOI: 10.1073/pnas.2303859120 |
0.616 |
|
| 2023 |
Li BE, Li GY, Cai W, Zhu Q, Seruggia D, Fujiwara Y, Vakoc CR, Orkin S. In vivo CRISPR/Cas9 Screening Identifies Pbrm1 as a Regulator of Mouse Myeloid Leukemia Development. Blood Advances. PMID 37428871 DOI: 10.1182/bloodadvances.2022009455 |
0.558 |
|
| 2023 |
Gao Y, He XY, Wu XS, Huang YH, Toneyan S, Ha T, Ipsaro JJ, Koo PK, Joshua-Tor L, Bailey KM, Egeblad M, Vakoc CR. ETV6 dependency in Ewing sarcoma by antagonism of EWS-FLI1-mediated enhancer activation. Nature Cell Biology. PMID 36658219 DOI: 10.1038/s41556-022-01060-1 |
0.36 |
|
| 2022 |
Mo Y, Duan S, Zhang X, Hua X, Zhou H, Wei HJ, Watanabe J, McQuillan N, Su Z, Gu W, Wu CC, Vakoc CR, Hashizume R, Chang K, Zhang Z. Epigenome programing by H3.3K27M mutation creates a dependence of pediatric glioma on SMARCA4. Cancer Discovery. PMID 36305747 DOI: 10.1158/2159-8290.CD-21-1492 |
0.308 |
|
| 2022 |
Orstad G, Fort G, Parnell TJ, Jones A, Stubben C, Lohman B, Gillis KL, Orellana W, Tariq R, Klingbeil O, Kaestner K, Vakoc CR, Spike BT, Snyder EL. FoxA1 and FoxA2 control growth and cellular identity in NKX2-1-positive lung adenocarcinoma. Developmental Cell. PMID 35835117 DOI: 10.1016/j.devcel.2022.06.017 |
0.303 |
|
| 2021 |
Laubscher D, Gryder BE, Sunkel BD, Andresson T, Wachtel M, Das S, Roschitzki B, Wolski W, Wu XS, Chou HC, Song YK, Wang C, Wei JS, Wang M, Wen X, ... ... Vakoc CR, et al. BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma. Nature Communications. 12: 6924. PMID 34836971 DOI: 10.1038/s41467-021-27176-w |
0.381 |
|
| 2021 |
Wei Y, Huang YH, Skopelitis DS, Iyer SV, Costa ASH, Yang Z, Kramer M, Adelman ER, Klingbeil O, Demerdash OE, Polyanskaya SA, Chang K, Goodwin S, Hodges E, McCombie WR, ... ... Vakoc CR, et al. SLC5A3-dependent myo-inositol auxotrophy in acute myeloid leukemia. Cancer Discovery. PMID 34531253 DOI: 10.1158/2159-8290.CD-20-1849 |
0.314 |
|
| 2021 |
Yang Z, Wu XS, Wei Y, Polyanskaya SA, Iyer SV, Jung M, Lach FP, Adelman ER, Klingbeil O, Milazzo JP, Kramer M, Demerdash OE, Chang K, Goodwin S, Hodges E, ... ... Vakoc CR, et al. Transcriptional silencing of ALDH2 confers a dependency on Fanconi anemia proteins in acute myeloid leukemia. Cancer Discovery. PMID 33893150 DOI: 10.1158/2159-8290.CD-20-1542 |
0.359 |
|
| 2020 |
Miyabayashi K, Baker LA, Deschenes A, Traub B, Caligiuri G, Plenker D, Alagesan B, Belleau P, Li S, Kendall J, Jang GH, Kawaguchi RK, Somerville TDD, Tiriac H, Hwang CI, ... ... Vakoc CR, et al. Intraductal transplantation models of human pancreatic ductal adenocarcinoma reveal progressive transition of molecular subtypes. Cancer Discovery. PMID 32703770 DOI: 10.1158/2159-8290.Cd-20-0133 |
0.3 |
|
| 2020 |
Oni TE, Biffi G, Baker LA, Hao Y, Tonelli C, Somerville TDD, Deschênes A, Belleau P, Hwang CI, Sánchez-Rivera FJ, Cox H, Brosnan E, Doshi A, Lumia RP, Khaledi K, ... ... Vakoc CR, et al. SOAT1 promotes mevalonate pathway dependency in pancreatic cancer. The Journal of Experimental Medicine. 217. PMID 32633781 DOI: 10.1084/Jem.20192389 |
0.321 |
|
| 2020 |
Wu XS, Vakoc CR. A pliable ERα cistrome evades therapy. Nature Cell Biology. 22: 619-620. PMID 32424274 DOI: 10.1038/S41556-020-0528-6 |
0.32 |
|
| 2020 |
Gryder BE, Wachtel M, Chang K, El Demerdash O, Aboreden NG, Mohammed W, Ewert W, Pomella S, Rota R, Wei JS, Song Y, Stanton BZ, Schäfer B, Vakoc CR, Khan J. Miswired Enhancer Logic Drives a Cancer of the Muscle Lineage. Iscience. 23: 101103. PMID 32416589 DOI: 10.1016/J.Isci.2020.101103 |
0.403 |
|
| 2020 |
Somerville TDD, Xu Y, Wu XS, Maia-Silva D, Hur SK, de Almeida LMN, Preall JB, Koo PK, Vakoc CR. ZBED2 is an antagonist of interferon regulatory factor 1 and modifies cell identity in pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 32385160 DOI: 10.1073/Pnas.1921484117 |
0.512 |
|
| 2020 |
Somerville TD, Biffi G, Daßler-Plenker J, Hur SK, He XY, Vance KE, Miyabayashi K, Xu Y, Maia-Silva D, Klingbeil O, Demerdash OE, Preall JB, Hollingsworth MA, Egeblad M, Tuveson DA, ... Vakoc CR, et al. Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation. Elife. 9. PMID 32329713 DOI: 10.7554/Elife.53381 |
0.365 |
|
| 2020 |
Somerville TD, Biffi G, Daßler-Plenker J, Hur SK, He X, Vance KE, Miyabayashi K, Xu Y, Maia-Silva D, Klingbeil O, Demerdash OE, Preall JB, Hollingsworth MA, Egeblad M, Tuveson DA, ... Vakoc CR, et al. Author response: Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation Elife. DOI: 10.7554/Elife.53381.Sa2 |
0.35 |
|
| 2020 |
Gryder BE, Wachtel M, Ewert W, Chang K, Demerdash OE, Song Y, Schäfer BW, Vakoc CR, Khan J. Abstract B12: PAX3 translocations co-opt super enhancers and intrinsically disordered fusion partners in rhabdomyosarcoma Cancer Research. 80. DOI: 10.1158/1538-7445.Pedca19-B12 |
0.481 |
|
| 2019 |
Foronda M, Tarumoto Y, Schatoff EM, Leach BI, Diaz BJ, Zimmerman J, Goswami S, Shusterman M, Vakoc CR, Dow LE. Tankyrase inhibition sensitizes cells to CDK4 blockade. Plos One. 14: e0226645. PMID 31891587 DOI: 10.1371/Journal.Pone.0226645 |
0.378 |
|
| 2019 |
Gryder BE, Pomella S, Sayers C, Wu XS, Song Y, Chiarella AM, Bagchi S, Chou HC, Sinniah RS, Walton A, Wen X, Rota R, Hathaway NA, Zhao K, Chen J, ... Vakoc CR, et al. Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma. Nature Genetics. 51: 1714-1722. PMID 31784732 DOI: 10.1038/S41588-019-0534-4 |
0.472 |
|
| 2019 |
Tarumoto Y, Lin S, Wang J, Milazzo JP, Xu Y, Lu B, Yang Z, Wei Y, Polyanskaya S, Wunderlich M, Gray NS, Stegmaier K, Vakoc CR. Salt-Inducible Kinase inhibition suppresses acute myeloid leukemia progression in vivo. Blood. PMID 31697837 DOI: 10.1182/Blood.2019001576 |
0.447 |
|
| 2019 |
Caiado F, Maia-Silva D, Jardim C, Schmolka N, Carvalho T, Reforço C, Faria R, Kolundzija B, Simões AE, Baubec T, Vakoc CR, da Silva MG, Manz MG, Schumacher TN, Norell H, et al. Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection. Nature Communications. 10: 4986. PMID 31676777 DOI: 10.1038/S41467-019-12983-Z |
0.379 |
|
| 2019 |
Li F, Deng Z, Zhang L, Wu C, Jin Y, Hwang I, Vladimirova O, Xu L, Yang L, Lu B, Dheekollu J, Li JY, Feng H, Hu J, Vakoc CR, et al. ATRX loss induces telomere dysfunction and necessitates induction of alternative lengthening of telomeres during human cell immortalization. The Embo Journal. e96659. PMID 31454099 DOI: 10.15252/Embj.201796659 |
0.37 |
|
| 2019 |
Ehrenhöfer-Wölfer K, Puchner T, Schwarz C, Rippka J, Blaha-Ostermann S, Strobl U, Hörmann A, Bader G, Kornigg S, Zahn S, Sommergruber W, Schweifer N, Zichner T, Schlattl A, Neumüller RA, ... ... Vakoc CR, et al. SMARCA2-deficiency confers sensitivity to targeted inhibition of SMARCA4 in esophageal squamous cell carcinoma cell lines. Scientific Reports. 9: 11661. PMID 31406271 DOI: 10.1038/S41598-019-48152-X |
0.382 |
|
| 2019 |
Böttcher J, Dilworth D, Reiser U, Neumüller RA, Schleicher M, Petronczki M, Zeeb M, Mischerikow N, Allali-Hassani A, Szewczyk MM, Li F, Kennedy S, Vedadi M, Barsyte-Lovejoy D, Brown PJ, ... ... Vakoc CR, et al. Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3. Nature Chemical Biology. PMID 31285596 DOI: 10.1038/S41589-019-0310-X |
0.401 |
|
| 2019 |
Bell CC, Fennell KA, Chan YC, Rambow F, Yeung MM, Vassiliadis D, Lara L, Yeh P, Martelotto LG, Rogiers A, Kremer BE, Barbash O, Mohammad HP, Johanson TM, Burr ML, ... ... Vakoc CR, et al. Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia. Nature Communications. 10: 2723. PMID 31222014 DOI: 10.1038/S41467-019-10652-9 |
0.366 |
|
| 2019 |
Lan X, Khandros E, Huang P, Peslak SA, Bhardwaj SK, Grevet JD, Abdulmalik O, Wang H, Keller CA, Giardine B, Baeza J, Duffner ER, El Demerdash O, Wu XS, Vakoc CR, et al. The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells. Blood Advances. 3: 1586-1597. PMID 31126914 DOI: 10.1182/Bloodadvances.2019032318 |
0.625 |
|
| 2019 |
Bharathy N, Berlow NE, Wang E, Abraham J, Settelmeyer TP, Hooper JE, Svalina MN, Bajwa Z, Goros MW, Hernandez BS, Wolff JE, Pal R, Davies AM, Ashok A, Bushby D, ... ... Vakoc CR, et al. Preclinical rationale for entinostat in embryonal rhabdomyosarcoma. Skeletal Muscle. 9: 12. PMID 31113472 DOI: 10.1186/S13395-019-0198-X |
0.386 |
|
| 2019 |
Rudin CM, Poirier JT, Byers LA, Dive C, Dowlati A, George J, Heymach JV, Johnson JE, Lehman JM, MacPherson D, Massion PP, Minna JD, Oliver TG, Quaranta V, Sage J, ... ... Vakoc CR, et al. Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data. Nature Reviews. Cancer. PMID 30926931 DOI: 10.1038/S41568-019-0133-9 |
0.384 |
|
| 2019 |
Aho ER, Wang J, Gogliotti RD, Howard GC, Phan J, Acharya P, Macdonald JD, Cheng K, Lorey SL, Lu B, Wenzel S, Foshage AM, Alvarado J, Wang F, Shaw JG, ... ... Vakoc CR, et al. Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Reports. 26: 2916-2928.e13. PMID 30865883 DOI: 10.1016/J.Celrep.2019.02.047 |
0.424 |
|
| 2019 |
Recker KL, Norton S, Sobh A, Riva A, Chang K, Kuznetsov J, Durante M, Flores F, Bennett RL, Vakoc C, Smalley K, Harbour W, Licht JD. Synthetic Lethal Screen to Identify Molecular Mechanisms that Drive Uveal Melanoma Uf Journal of Undergraduate Research. 21. DOI: 10.32473/ufjur.v21i1.108370 |
0.314 |
|
| 2019 |
Lin S, Tarumoto Y, Wang J, Milazzo J, Xu Y, Gray N, Vakoc C, Stegmaier K. Targeting Salt-Inducible Kinase 3 As a Therapeutic Approach for Acute Myeloid Leukemia Blood. 134: 3941-3941. DOI: 10.1182/Blood-2019-125278 |
0.48 |
|
| 2019 |
Wei YL, Vakoc C. Probing leukemia vulnerabilities in vivousing domain-focused CRISPR screening Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-5161 |
0.438 |
|
| 2019 |
Hwang C, Roe J, Lee EJ, Tonelli C, Somervile TDD, Yao M, Milazzo JP, Tiriac H, Park Y, Vakoc C, Tuveson D. Abstract B25: Engrailed-1 promotes pancreatic cancer progression via antagonizing COMPASS activity Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-B25 |
0.408 |
|
| 2019 |
Wei Y, Vakoc C. Abstract 5161: Probing leukemia vulnerabilitiesin vivousing domain-focused CRISPR screening Cancer Research. 79: 5161-5161. DOI: 10.1158/1538-7445.Am2019-5161 |
0.431 |
|
| 2019 |
Stripay J, Morfouace M, Vakoc C, Roussel M. MEDU-24. INTERROGATING THE ROLE OF EPIGENETIC REGULATORS IN MYC-DRIVEN MEDULLOBLASTOMA Neuro-Oncology. 21: ii108-ii108. DOI: 10.1093/Neuonc/Noz036.183 |
0.432 |
|
| 2018 |
Lu B, Klingbeil O, Tarumoto Y, Somerville TDD, Huang YH, Wei Y, Wai DC, Low JKK, Milazzo JP, Wu XS, Cao Z, Yan X, Demerdash OE, Huang G, Mackay JP, ... ... Vakoc CR, et al. A Transcription Factor Addiction in Leukemia Imposed by the MLL Promoter Sequence. Cancer Cell. PMID 30503706 DOI: 10.1016/J.Ccell.2018.10.015 |
0.522 |
|
| 2018 |
Bharathy N, Berlow NE, Wang E, Abraham J, Settelmeyer TP, Hooper JE, Svalina MN, Ishikawa Y, Zientek K, Bajwa Z, Goros MW, Hernandez BS, Wolff JE, Rudek MA, Xu L, ... ... Vakoc CR, et al. The HDAC3-SMARCA4-miR-27a axis promotes expression of the fusion oncogene in rhabdomyosarcoma. Science Signaling. 11. PMID 30459282 DOI: 10.1126/Scisignal.Aau7632 |
0.342 |
|
| 2018 |
Brien GL, Remillard D, Shi J, Hemming ML, Chabon J, Wynne K, Dillon ET, Cagney G, Van Mierlo G, Baltissen MP, Vermeulen M, Qi J, Fröhling S, Gray NS, Bradner JE, ... Vakoc CR, et al. Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma. Elife. 7. PMID 30431433 DOI: 10.7554/Elife.41305 |
0.448 |
|
| 2018 |
Somerville TDD, Xu Y, Miyabayashi K, Tiriac H, Cleary CR, Maia-Silva D, Milazzo JP, Tuveson DA, Vakoc CR. TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma. Cell Reports. 25: 1741-1755.e7. PMID 30428345 DOI: 10.1016/J.Celrep.2018.10.051 |
0.421 |
|
| 2018 |
Vakoc CR, Kentsis A. Disabling an oncogenic transcription factor by targeting of control kinases. Oncotarget. 9: 32276-32277. PMID 30190784 DOI: 10.18632/Oncotarget.25971 |
0.368 |
|
| 2018 |
Hörmann A, Hopfgartner B, Köcher T, Corcokovic M, Krammer T, Reiser C, Bader G, Shi J, Ehrenhöfer K, Wöhrle S, Schweifer N, Vakoc CR, Kraut N, Pearson M, Petronczki M, et al. RIOK1 kinase activity is required for cell survival irrespective of status. Oncotarget. 9: 28625-28637. PMID 29983885 DOI: 10.18632/Oncotarget.25586 |
0.413 |
|
| 2018 |
Huang YH, Klingbeil O, He XY, Wu XS, Arun G, Lu B, Somerville TDD, Milazzo JP, Wilkinson JE, Demerdash OE, Spector DL, Egeblad M, Shi J, Vakoc CR. POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer. Genes & Development. PMID 29945888 DOI: 10.1101/Gad.314815.118 |
0.404 |
|
| 2018 |
Tiriac H, Belleau P, Engle DD, Plenker D, Deschênes A, Somerville T, Froeling FEM, Burkhart RA, Denroche RE, Jang GH, Miyabayashi K, Young CM, Patel H, Ma M, LaComb JF, ... ... Vakoc CR, et al. Organoid profiling identifies common responders to chemotherapy in pancreatic cancer. Cancer Discovery. PMID 29853643 DOI: 10.1158/2159-8290.Cd-18-0349 |
0.324 |
|
| 2018 |
Skucha A, Ebner J, Schmöllerl J, Roth M, Eder T, César-Razquin A, Stukalov A, Vittori S, Muhar M, Lu B, Aichinger M, Jude J, Müller AC, Győrffy B, Vakoc CR, et al. MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity. Nature Communications. 9: 1983. PMID 29777171 DOI: 10.1038/S41467-018-04329-Y |
0.447 |
|
| 2018 |
Wai DC, Szyszka TN, Campbell AE, Kwong C, Wilkinson-White LE, Silva APG, Low JKK, Kwan AH, Gamsjaeger R, Chalmers JN, Patrick WM, Lu B, Vakoc CR, Blobel G, Mackay JP. The BRD3 ET domain recognizes a short peptide motif through a mechanism that is conserved across chromatin remodelers and transcriptional regulators. The Journal of Biological Chemistry. PMID 29567837 DOI: 10.1074/Jbc.Ra117.000678 |
0.657 |
|
| 2018 |
Tarumoto Y, Lu B, Somerville TDD, Huang YH, Milazzo JP, Wu XS, Klingbeil O, El Demerdash O, Shi J, Vakoc CR. LKB1, Salt-Inducible Kinases, and MEF2C Are Linked Dependencies in Acute Myeloid Leukemia. Molecular Cell. PMID 29526696 DOI: 10.1016/J.Molcel.2018.02.011 |
0.439 |
|
| 2018 |
Banito A, Li X, Laporte AN, Roe JS, Sanchez-Vega F, Huang CH, Dancsok AR, Hatzi K, Chen CC, Tschaharganeh DF, Chandwani R, Tasdemir N, Jones KB, Capecchi MR, Vakoc CR, et al. The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma. Cancer Cell. PMID 29502955 DOI: 10.1016/J.Ccell.2018.01.018 |
0.526 |
|
| 2018 |
Bhagwat AS, Lu B, Vakoc CR. Enhancer dysfunction in leukemia. Blood. PMID 29439951 DOI: 10.1182/Blood-2017-11-737379 |
0.526 |
|
| 2018 |
Xu Y, Milazzo JP, Somerville TDD, Tarumoto Y, Huang YH, Ostrander EL, Wilkinson JE, Challen GA, Vakoc CR. A TFIID-SAGA Perturbation that Targets MYB and Suppresses Acute Myeloid Leukemia. Cancer Cell. 33: 13-28.e8. PMID 29316427 DOI: 10.1016/J.Ccell.2017.12.002 |
0.486 |
|
| 2018 |
Brien GL, Remillard D, Shi J, Hemming ML, Chabon J, Wynne K, Dillon ET, Cagney G, Mierlo GV, Baltissen MP, Vermeulen M, Qi J, Fröhling S, Gray NS, Bradner JE, ... Vakoc CR, et al. Author response: Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma Elife. DOI: 10.7554/Elife.41305.044 |
0.375 |
|
| 2018 |
Vakoc C. Abstract IA07: Cancer drug target identification using domain-focused CRISPR screening Clinical Cancer Research. 24. DOI: 10.1158/1557-3265.Sarcomas17-Ia07 |
0.329 |
|
| 2017 |
Barbieri I, Tzelepis K, Pandolfini L, Shi J, Millán-Zambrano G, Robson SC, Aspris D, Migliori V, Bannister AJ, Han N, De Braekeleer E, Ponstingl H, Hendrick A, Vakoc CR, Vassiliou GS, et al. Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control. Nature. 552: 126-131. PMID 29186125 DOI: 10.1038/Nature24678 |
0.535 |
|
| 2017 |
Fontanals-Cirera B, Hasson D, Vardabasso C, Di Micco R, Agrawal P, Chowdhury A, Gantz M, de Pablos-Aragoneses A, Morgenstern A, Wu P, Filipescu D, Valle-Garcia D, Darvishian F, Roe JS, Davies MA, ... Vakoc CR, et al. Harnessing BET Inhibitor Sensitivity Reveals AMIGO2 as a Melanoma Survival Gene. Molecular Cell. 68: 731-744.e9. PMID 29149598 DOI: 10.1016/J.Molcel.2017.11.004 |
0.458 |
|
| 2017 |
Roe JS, Hwang CI, Somerville TDD, Milazzo JP, Lee EJ, Da Silva B, Maiorino L, Tiriac H, Young CM, Miyabayashi K, Filippini D, Creighton B, Burkhart RA, Buscaglia JM, Kim EJ, ... ... Vakoc CR, et al. Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis. Cell. PMID 28757253 DOI: 10.1016/J.Cell.2017.07.007 |
0.415 |
|
| 2017 |
Lanning BR, Vakoc CR. Single-minded CRISPR screening. Nature Biotechnology. 35: 339-340. PMID 28398325 DOI: 10.1038/Nbt.3849 |
0.308 |
|
| 2017 |
Vakoc CR, Tuveson DA. Untangling the genetics from the epigenetics in pancreatic cancer metastasis. Nature Genetics. 49: 323-324. PMID 28232730 DOI: 10.1038/Ng.3798 |
0.337 |
|
| 2017 |
Ipsaro JJ, Shen C, Arai E, Xu Y, Kinney JB, Joshua-Tor L, Vakoc CR, Shi J. Rapid generation of drug-resistance alleles at endogenous loci using CRISPR-Cas9 indel mutagenesis. Plos One. 12: e0172177. PMID 28231254 DOI: 10.1371/Journal.Pone.0172177 |
0.314 |
|
| 2017 |
Xu Y, Vakoc CR. Targeting Cancer Cells with BET Bromodomain Inhibitors. Cold Spring Harbor Perspectives in Medicine. PMID 28213432 DOI: 10.1101/Cshperspect.A026674 |
0.52 |
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| 2017 |
Roe JS, Vakoc CR. The Essential Transcriptional Function of BRD4 in Acute Myeloid Leukemia. Cold Spring Harbor Symposia On Quantitative Biology. PMID 28174254 DOI: 10.1101/Sqb.2016.81.031039 |
0.523 |
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| 2017 |
Vakoc C. Abstract IA24: Transcriptional regulators as cancer dependencies Clinical Cancer Research. 23. DOI: 10.1158/1557-3265.Pmccavuln16-Ia24 |
0.521 |
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| 2016 |
Oran AR, Adams CM, Zhang XY, Gennaro VJ, Pfeiffer HK, Mellert HS, Seidel HE, Mascioli K, Kaplan J, Gaballa MR, Shen C, Rigoutsos I, King MP, Cotney JL, Arnold JJ, ... ... Vakoc CR, et al. Multi-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer. Oncotarget. PMID 27590350 DOI: 10.18632/Oncotarget.11718 |
0.388 |
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| 2016 |
Somerville TD, Vakoc CR. Modeling the Epigenetic Chain Reaction Downstream of DNMT3A(R882H). Cancer Cell. 30: 9-10. PMID 27411582 DOI: 10.1016/J.Ccell.2016.06.018 |
0.344 |
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| 2016 |
Hohmann AF, Martin LJ, Minder JL, Roe JS, Shi J, Steurer S, Bader G, McConnell D, Pearson M, Gerstberger T, Gottschamel T, Thompson D, Suzuki Y, Koegl M, Vakoc CR. Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibition. Nature Chemical Biology. PMID 27376689 DOI: 10.1038/Nchembio.2115 |
0.423 |
|
| 2016 |
Zhang Q, Zeng L, Shen C, Ju Y, Konuma T, Zhao C, Vakoc CR, Zhou MM. Structural Mechanism of Transcriptional Regulator NSD3 Recognition by the ET Domain of BRD4. Structure (London, England : 1993). PMID 27291650 DOI: 10.1016/J.Str.2016.04.019 |
0.419 |
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| 2016 |
Tasdemir N, Banito A, Roe JS, Alonso-Curbelo D, Camiolo M, Tschaharganeh DF, Huang CH, Aksoy O, Bolden JE, Chen CC, Fennell M, Thapar V, Chicas A, Vakoc CR, Lowe SW. BRD4 connects enhancer remodeling to senescence immune surveillance. Cancer Discovery. PMID 27099234 DOI: 10.1158/2159-8290.Cd-16-0217 |
0.475 |
|
| 2016 |
Bhagwat AS, Roe JS, Mok BY, Hohmann AF, Shi J, Vakoc CR. BET Bromodomain Inhibition Releases the Mediator Complex from Select cis-Regulatory Elements. Cell Reports. PMID 27068464 DOI: 10.1016/J.Celrep.2016.03.054 |
0.521 |
|
| 2016 |
Martin LJ, Koegl M, Bader G, Cockcroft XL, Fedorov O, Fiegen D, Gerstberger T, Hofmann MH, Hohmann AF, Kessler D, Knapp S, Knesl P, Kornigg S, Müller S, Nar H, ... ... Vakoc CR, et al. Structure-based design of an in vivo active selective BRD9 inhibitor. Journal of Medicinal Chemistry. PMID 26914985 DOI: 10.1021/Acs.Jmedchem.5B01865 |
0.367 |
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| 2016 |
Bhagwat AS, Roe J, Mok BA, Vakoc CR. Abstract B28: BET bromodomain inhibitors antagonize Brd4-Mediator complexes to undermine the acute myeloid leukemia cell state Cancer Research. 76. DOI: 10.1158/1538-7445.Chromepi15-B28 |
0.531 |
|
| 2016 |
Hohmann AF, Martin LJ, Minder J, Roe J, Shi J, Steurer S, Bader G, McConnell D, Pearson M, Gerstberger T, Gottschamel T, Thompson D, Suzuki Y, Koegl M, Vakoc C. Abstract LB-206: A bromodomain-swap allele demonstrates that on-target chemical inhibition of BRD9 limits the proliferation of acute myeloid leukemia cells Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Lb-206 |
0.465 |
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| 2016 |
Shen C, Ipsaro JJ, Shi J, Vakoc CR. Abstract 884: NSD3-short is an adaptor protein that couples BRD4 to the CHD8 chromatin remodeler Cancer Research. 76: 884-884. DOI: 10.1158/1538-7445.Am2016-884 |
0.496 |
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| 2016 |
Gennaro V, Zhang X, DeSalle L, Yu D, Thomas-Tikhonenko A, Vakoc C, McMahon SB. Abstract 4553: Identification of CD30/TNFRSF8 as a primary target of the Myc oncoprotein and potential biomarker of Myc-driven cancer Cancer Research. 76: 4553-4553. DOI: 10.1158/1538-7445.Am2016-4553 |
0.377 |
|
| 2015 |
Bhagwat AS, Vakoc CR. Targeting Transcription Factors in Cancer. Trends in Cancer. 1: 53-65. PMID 26645049 DOI: 10.1016/J.Trecan.2015.07.001 |
0.414 |
|
| 2015 |
Shen C, Ipsaro JJ, Shi J, Milazzo JP, Wang E, Roe JS, Suzuki Y, Pappin DJ, Joshua-Tor L, Vakoc CR. NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler. Molecular Cell. PMID 26626481 DOI: 10.1016/J.Molcel.2015.10.033 |
0.496 |
|
| 2015 |
Matthews GM, Mehdipour P, Cluse LA, Falkenberg KJ, Wang E, Roth M, Santoro F, Vidacs E, Stanley K, House CM, Rusche JR, Vakoc CR, Zuber J, Minucci S, Johnstone RW. Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies. Blood. PMID 26447190 DOI: 10.1182/Blood-2015-03-632984 |
0.416 |
|
| 2015 |
Rathert P, Roth M, Neumann T, Muerdter F, Roe JS, Muhar M, Deswal S, Cerny-Reiterer S, Peter B, Jude J, Hoffmann T, Boryń ŁM, Axelsson E, Schweifer N, Tontsch-Grunt U, ... ... Vakoc CR, et al. Transcriptional plasticity promotes primary and acquired resistance to BET inhibition. Nature. 525: 543-7. PMID 26367798 DOI: 10.1038/Nature14898 |
0.478 |
|
| 2015 |
Roe JS, Mercan F, Rivera K, Pappin DJ, Vakoc CR. BET Bromodomain Inhibition Suppresses the Function of Hematopoietic Transcription Factors in Acute Myeloid Leukemia. Molecular Cell. 58: 1028-39. PMID 25982114 DOI: 10.1016/J.Molcel.2015.04.011 |
0.521 |
|
| 2015 |
Shi J, Wang E, Milazzo JP, Wang Z, Kinney JB, Vakoc CR. Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains. Nature Biotechnology. 33: 661-7. PMID 25961408 DOI: 10.1038/Nbt.3235 |
0.394 |
|
| 2015 |
Wang E, Kawaoka S, Roe JS, Shi J, Hohmann AF, Xu Y, Bhagwat AS, Suzuki Y, Kinney JB, Vakoc CR. The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer. Elife. 4: e06377. PMID 25919951 DOI: 10.7554/Elife.06377 |
0.469 |
|
| 2015 |
Shen C, Vakoc CR. Gain-of-function mutation of chromatin regulators as a tumorigenic mechanism and an opportunity for therapeutic intervention. Current Opinion in Oncology. 27: 57-63. PMID 25402979 DOI: 10.1097/Cco.0000000000000151 |
0.362 |
|
| 2015 |
Wang E, Kawaoka S, Roe J, Shi J, Hohmann AF, Xu Y, Bhagwat AS, Suzuki Y, Kinney JB, Vakoc CR. Author response: The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer Elife. DOI: 10.7554/Elife.06377.022 |
0.344 |
|
| 2015 |
Roe JS, Mercan F, Rivera K, Pappin DJ, Vakoc CR. BET Bromodomain Inhibition Suppresses the Function of Hematopoietic Transcription Factors in Acute Myeloid Leukemia Molecular Cell. 58: 1028-1039. DOI: 10.1016/j.molcel.2015.04.011 |
0.303 |
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| 2014 |
Xu Y, Vakoc CR. Brd4 is on the move during inflammation. Trends in Cell Biology. 24: 615-6. PMID 25288306 DOI: 10.1016/J.Tcb.2014.09.005 |
0.412 |
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| 2014 |
Hohmann AF, Vakoc CR. A rationale to target the SWI/SNF complex for cancer therapy. Trends in Genetics : Tig. 30: 356-63. PMID 24932742 DOI: 10.1016/J.Tig.2014.05.001 |
0.43 |
|
| 2014 |
Mazurek A, Park Y, Miething C, Wilkinson JE, Gillis J, Lowe SW, Vakoc CR, Stillman B. Acquired dependence of acute myeloid leukemia on the DEAD-box RNA helicase DDX5. Cell Reports. 7: 1887-99. PMID 24910429 DOI: 10.1016/J.Celrep.2014.05.019 |
0.364 |
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| 2014 |
Shi J, Vakoc CR. The mechanisms behind the therapeutic activity of BET bromodomain inhibition. Molecular Cell. 54: 728-36. PMID 24905006 DOI: 10.1016/J.Molcel.2014.05.016 |
0.556 |
|
| 2014 |
Alpatov R, Lesch BJ, Nakamoto-Kinoshita M, Blanco A, Chen S, Stützer A, Armache KJ, Simon MD, Xu C, Ali M, Murn J, Prisic S, Kutateladze TG, Vakoc CR, Min J, et al. A chromatin-dependent role of the fragile X mental retardation protein FMRP in the DNA damage response. Cell. 157: 869-81. PMID 24813610 DOI: 10.1016/J.Cell.2014.03.040 |
0.408 |
|
| 2014 |
Chen C, Liu Y, Rappaport AR, Kitzing T, Schultz N, Zhao Z, Shroff AS, Dickins RA, Vakoc CR, Bradner JE, Stock W, LeBeau MM, Shannon KM, Kogan S, Zuber J, et al. MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia Cancer Cell. 25: 652-665. PMID 24794707 DOI: 10.1016/J.Ccr.2014.03.016 |
0.316 |
|
| 2014 |
Bhagwat AS, Vakoc CR. A new bump in the epigenetic landscape. Molecular Cell. 53: 857-8. PMID 24656126 DOI: 10.1016/J.Molcel.2014.03.001 |
0.39 |
|
| 2014 |
Roe JS, Vakoc CR. C/EBPα: critical at the origin of leukemic transformation. The Journal of Experimental Medicine. 211: 1-4. PMID 24395889 DOI: 10.1084/Jem.20132530 |
0.457 |
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| 2013 |
Shi J, Whyte WA, Zepeda-Mendoza CJ, Milazzo JP, Shen C, Roe JS, Minder JL, Mercan F, Wang E, Eckersley-Maslin MA, Campbell AE, Kawaoka S, Shareef S, Zhu Z, Kendall J, ... ... Vakoc CR, et al. Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation. Genes & Development. 27: 2648-62. PMID 24285714 DOI: 10.1101/Gad.232710.113 |
0.718 |
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| 2013 |
King B, Trimarchi T, Reavie L, Xu L, Mullenders J, Ntziachristos P, Aranda-Orgilles B, Perez-Garcia A, Shi J, Vakoc C, Sandy P, Shen SS, Ferrando A, Aifantis I. The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability. Cell. 153: 1552-66. PMID 23791182 DOI: 10.1016/J.Cell.2013.05.041 |
0.379 |
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| 2013 |
Roe JS, Vakoc CR. Oncogene interference through targeting of chromatin regulators. Cell Cycle (Georgetown, Tex.). 12: 1475-6. PMID 23624838 DOI: 10.4161/Cc.24748 |
0.545 |
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| 2013 |
Lovén J, Hoke HA, Lin CY, Lau A, Orlando DA, Vakoc CR, Bradner JE, Lee TI, Young RA. Selective inhibition of tumor oncogenes by disruption of super-enhancers. Cell. 153: 320-34. PMID 23582323 DOI: 10.1016/J.Cell.2013.03.036 |
0.472 |
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| 2013 |
Wang E, Kawaoka S, Yu M, Shi J, Ni T, Yang W, Zhu J, Roeder RG, Vakoc CR. Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia. Proceedings of the National Academy of Sciences of the United States of America. 110: 3901-6. PMID 23412334 DOI: 10.1073/Pnas.1301045110 |
0.562 |
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| 2013 |
Shi J, Wang E, Zuber J, Rappaport A, Taylor M, Johns C, Lowe SW, Vakoc CR. The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras G12D acute myeloid leukemia Oncogene. 32: 930-938. PMID 22469984 DOI: 10.1038/Onc.2012.110 |
0.514 |
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| 2013 |
Wedeh G, Hadzijusufovic E, Cerny-Reiterer S, Herrmann H, Blatt K, Eisenwort G, Hoermann G, Sperr WR, Müllauer L, Vakoc CR, Bradner JE, Horny H, Willmann M, Zuber J, Arock M, et al. Bromodomain-Containing Protein 4 (BRD4): A Novel Marker and Drug Target Expressed In Neoplastic Cells In Advanced Mast Cell Neoplasms Blood. 122: 3747-3747. DOI: 10.1182/Blood.V122.21.3747.3747 |
0.376 |
|
| 2012 |
Herrmann H, Blatt K, Shi J, Gleixner KV, Cerny-Reiterer S, Müllauer L, Vakoc CR, Sperr WR, Horny HP, Bradner JE, Zuber J, Valent P. Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia (AML) Oncotarget. 3: 1588-1599. PMID 23249862 DOI: 10.18632/Oncotarget.733 |
0.362 |
|
| 2012 |
Ernst P, Vakoc CR. WRAD: enabler of the SET1-family of H3K4 methyltransferases. Briefings in Functional Genomics. 11: 217-26. PMID 22652693 DOI: 10.1093/Bfgp/Els017 |
0.393 |
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| 2012 |
Vakoc CR, Wang E, Kawaoka S. MLL-Rearranged Leukemias Are Dependent On the Histone H2B Ubiquitin Ligase RNF20 Blood. 120: 649-649. DOI: 10.1182/Blood.V120.21.649.649 |
0.507 |
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| 2011 |
Delmore JE, Issa GC, Lemieux ME, Rahl PB, Shi J, Jacobs HM, Kastritis E, Gilpatrick T, Paranal RM, Qi J, Chesi M, Schinzel AC, McKeown MR, Heffernan TP, Vakoc CR, et al. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell. 146: 904-17. PMID 21889194 DOI: 10.1016/J.Cell.2011.08.017 |
0.489 |
|
| 2011 |
Zuber J, Rappaport AR, Luo W, Wang E, Chen C, Vaseva AV, Shi J, Weissmueller S, Fellmann C, Fellman C, Taylor MJ, Weissenboeck M, Graeber TG, Kogan SC, Vakoc CR, et al. An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance. Genes & Development. 25: 1628-40. PMID 21828272 DOI: 10.1101/Gad.17269211 |
0.428 |
|
| 2011 |
Zuber J, Shi J, Wang E, Rappaport AR, Herrmann H, Sison EA, Magoon D, Qi J, Blatt K, Wunderlich M, Taylor MJ, Johns C, Chicas A, Mulloy JC, Kogan SC, ... ... Vakoc CR, et al. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature. 478: 524-8. PMID 21814200 DOI: 10.1038/Nature10334 |
0.528 |
|
| 2011 |
Herrmann H, Blatt K, Shi J, Rappaport AR, Gleixner KV, Cerny-Reiterer S, Peter B, Wang E, Sperr WR, Bradner JE, Lowe SW, Vakoc CR, Zuber J, Valent P. Small-Molecule Inhibition of BRD4 Is a Novel Promising Approach to Therapeutically Target Leukemia Stem Cells in AML, Blood. 118: 3484-3484. DOI: 10.1182/Blood.V118.21.3484.3484 |
0.453 |
|
| 2011 |
Issa GC, Delmore JE, McKeown MR, Lemieux ME, Rahl PB, Jacobs HM, Kastritis E, Gilpatrick T, Paranal RM, Qi J, Shi J, Chesi M, Schinzel AC, Vakoc CR, Bergsagel P, et al. Inhibition of c-Myc Expression and Function in Hematologic Malignancies Blood. 118: 1409-1409. DOI: 10.1182/Blood.V118.21.1409.1409 |
0.405 |
|
| 2010 |
Speck NA, Vakoc CR. PAF is in the cabal of MLL1-interacting proteins that promote leukemia. Cancer Cell. 17: 531-2. PMID 20541697 DOI: 10.1016/J.Ccr.2010.05.019 |
0.455 |
|
| 2010 |
Vakoc C, Zuber J, Lowe S, Wang E, Rappaport A, Shi J. An RNAi Screen Reveals a Pattern of Addiction to Epigenetic Pathways That Distinguishes MLL-AF9 Leukemia From Normal Hematopoietic Cells Blood. 116: 65-65. DOI: 10.1182/Blood.V116.21.65.65 |
0.538 |
|
| 2009 |
Blobel GA, Kadauke S, Wang E, Lau AW, Zuber J, Chou MM, Vakoc CR. A reconfigured pattern of MLL occupancy within mitotic chromatin promotes rapid transcriptional reactivation following mitotic exit. Molecular Cell. 36: 970-83. PMID 20064463 DOI: 10.1016/J.Molcel.2009.12.001 |
0.803 |
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| 2009 |
Chou ST, Khandros E, Bailey LC, Nichols KE, Vakoc CR, Yao Y, Huang Z, Crispino JD, Hardison RC, Blobel GA, Weiss MJ. Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate. Blood. 114: 983-94. PMID 19491391 DOI: 10.1182/Blood-2009-03-207944 |
0.67 |
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| 2009 |
Vakoc CR, Wen YY, Gibbs RA, Johnstone CN, Rustgi AK, Blobel GA. Low frequency of MLL3 mutations in colorectal carcinoma. Cancer Genetics and Cytogenetics. 189: 140-1. PMID 19215798 DOI: 10.1016/J.Cancergencyto.2008.10.014 |
0.557 |
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| 2009 |
Tripic T, Deng W, Cheng Y, Zhang Y, Vakoc CR, Gregory GD, Hardison RC, Blobel GA. SCL and associated proteins distinguish active from repressive GATA transcription factor complexes. Blood. 113: 2191-201. PMID 19011221 DOI: 10.1182/Blood-2008-07-169417 |
0.739 |
|
| 2008 |
Steger DJ, Lefterova MI, Ying L, Stonestrom AJ, Schupp M, Zhuo D, Vakoc AL, Kim JE, Chen J, Lazar MA, Blobel GA, Vakoc CR. DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. Molecular and Cellular Biology. 28: 2825-39. PMID 18285465 DOI: 10.1128/Mcb.02076-07 |
0.69 |
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| 2008 |
Jing H, Vakoc CR, Ying L, Mandat S, Wang H, Zheng X, Blobel GA. Exchange of GATA factors mediates transitions in looped chromatin organization at a developmentally regulated gene locus. Molecular Cell. 29: 232-42. PMID 18243117 DOI: 10.1016/J.Molcel.2007.11.020 |
0.701 |
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| 2007 |
Gregory GD, Vakoc CR, Rozovskaia T, Zheng X, Patel S, Nakamura T, Canaani E, Blobel GA. Mammalian ASH1L is a histone methyltransferase that occupies the transcribed region of active genes. Molecular and Cellular Biology. 27: 8466-79. PMID 17923682 DOI: 10.1128/Mcb.00993-07 |
0.667 |
|
| 2007 |
Chou ST, Bailey CL, Hardison RC, Blobel GA, Vakoc CR, Weiss MJ. GATA-1 Represses PU.1/Sfpi-1 Gene Transcription in Erythro-Megakaryocytic Progenitors. Blood. 110: 1226-1226. DOI: 10.1182/Blood.V110.11.1226.1226 |
0.689 |
|
| 2007 |
Jing H, Vakoc C, Wang H, Mandat S, Miller J, Gregory P, Reik A, Blobel G. Regulation of higher order chromatin organization by GATA-1 Blood Cells, Molecules, and Diseases. 38: 126. DOI: 10.1016/J.Bcmd.2006.10.017 |
0.578 |
|
| 2006 |
Zeng PY, Vakoc CR, Chen ZC, Blobel GA, Berger SL. In vivo dual cross-linking for identification of indirect DNA-associated proteins by chromatin immunoprecipitation. Biotechniques. 41: 694, 696, 698. PMID 17191611 DOI: 10.2144/000112297 |
0.604 |
|
| 2006 |
Vakoc CR, Sachdeva MM, Wang H, Blobel GA. Profile of histone lysine methylation across transcribed mammalian chromatin. Molecular and Cellular Biology. 26: 9185-95. PMID 17030614 DOI: 10.1128/Mcb.01529-06 |
0.675 |
|
| 2006 |
Lamonica JM, Vakoc CR, Blobel GA. Acetylation of GATA-1 is required for chromatin occupancy. Blood. 108: 3736-8. PMID 16888089 DOI: 10.1182/Blood-2006-07-032847 |
0.795 |
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| 2005 |
Vakoc CR, Mandat SA, Olenchock BA, Blobel GA. Histone H3 lysine 9 methylation and HP1gamma are associated with transcription elongation through mammalian chromatin. Molecular Cell. 19: 381-91. PMID 16061184 DOI: 10.1016/J.Molcel.2005.06.011 |
0.657 |
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| 2005 |
Hong W, Nakazawa M, Chen YY, Kori R, Vakoc CR, Rakowski C, Blobel GA. FOG-1 recruits the NuRD repressor complex to mediate transcriptional repression by GATA-1. The Embo Journal. 24: 2367-78. PMID 15920470 DOI: 10.1038/Sj.Emboj.7600703 |
0.697 |
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| 2005 |
Vakoc CR, Letting DL, Gheldof N, Sawado T, Bender MA, Groudine M, Weiss MJ, Dekker J, Blobel GA. Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1. Molecular Cell. 17: 453-62. PMID 15694345 DOI: 10.1016/J.Molcel.2004.12.028 |
0.749 |
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| 2005 |
Dore LC, Vakoc CR, Blobel GA, Hardison RC, Bodine DM, Gallagher PG, Weiss MJ. Genomic Organization, Chromatin Structure, and Transcriptional Regulation of the Murine Alpha Hemoglobin Stabilizing Protein (AHSP) Gene. Blood. 106: 3633-3633. DOI: 10.1182/Blood.V106.11.3633.3633 |
0.687 |
|
| 2005 |
Vakoc CR, Mandat SA, Olenschock BA, Blobel GA. Histone H3 Lysine 9 Methylation and HP1γ Are Associated with Transcription Elongation through Mammalian Chromatin. Blood. 106: 1734-1734. DOI: 10.1182/Blood.V106.11.1734.1734 |
0.684 |
|
| 2004 |
Welch JJ, Watts JA, Vakoc CR, Yao Y, Wang H, Hardison RC, Blobel GA, Chodosh LA, Weiss MJ. Global regulation of erythroid gene expression by transcription factor GATA-1. Blood. 104: 3136-47. PMID 15297311 DOI: 10.1182/Blood-2004-04-1603 |
0.693 |
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| 2004 |
Vakoc C, Dekker J, Blobel GA. GATA-1 Directly Induces Physical Proximity between the LCR and β Globin Promoter in Erythroid Cells. Blood. 104: 1612-1612. DOI: 10.1182/Blood.V104.11.1612.1612 |
0.679 |
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