Youhai H. Chen - Publications

Cell and Molecular Biology University of Pennsylvania, Philadelphia, PA, United States 
Molecular Biology, Cell Biology, Immunology

60 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Li X, Luo G, Li T, Sun H, Wang W, Eiler E, Goldsmith JR, Chen YH. The c-Rel-c-Myc axis controls metabolism and proliferation of human T leukemia cells. Molecular Immunology. 125: 115-122. PMID 32659596 DOI: 10.1016/j.molimm.2020.06.029  0.44
2020 Tian Z, Shofer FS, Yao L, Sun H, Zhang H, Qin L, Chen YH, Zhang Y. TNFAIP8 family gene expressions in the mouse tail intervertebral disc injury model. Jor Spine. 3: e1093. PMID 32613168 DOI: 10.1002/jsp2.1093  0.44
2020 Goldsmith JR, Spitofsky N, Zamani A, Hood R, Boggs A, Li X, Li M, Reiner E, Ayyaz A, Etwebi Z, Lu L, Rivera Guzman J, Bou-Dargham MJ, Cathoupolis T, Hakonarson H, ... ... Chen YH, et al. TNFAIP8 controls murine intestinal stem cell homeostasis and regeneration by regulating microbiome-induced Akt signaling. Nature Communications. 11: 2591. PMID 32444641 DOI: 10.1038/s41467-020-16379-2  0.44
2020 Wang Y, Zhang H, Wang Z, Wei Y, Wang M, Liu M, Wang X, Jiang Y, Shi G, Zhao D, Yang Z, Ren Z, Li J, Zhang Z, Wang Z, ... ... Chen YH, et al. Blocking the death checkpoint protein TRAIL improves cardiac function after myocardial infarction in monkeys, pigs, and rats. Science Translational Medicine. 12. PMID 32321866 DOI: 10.1126/scitranslmed.aaw3172  0.44
2020 Sun H, Lin M, Zamani A, Goldsmith JR, Boggs AE, Li M, Lee CN, Chen X, Li X, Li T, Dorrity BL, Li N, Lou Y, Shi S, Wang W, ... Chen YH, et al. The TIPE Molecular Pilot That Directs Lymphocyte Migration in Health and Inflammation. Scientific Reports. 10: 6617. PMID 32313148 DOI: 10.1038/s41598-020-63629-w  0.44
2020 Lou Y, Han M, Song Y, Zhong J, Zhang W, Chen YH, Wang H. The SCF E3 Ubiquitin Ligase Regulates Immune Receptor Signaling by Targeting the Negative Regulatory Protein TIPE2. Journal of Immunology (Baltimore, Md. : 1950). PMID 32188758 DOI: 10.4049/jimmunol.1901142  0.44
2019 Yan D, Wang J, Sun H, Zamani A, Zhang H, Chen W, Tang A, Ruan Q, Yang X, Chen YH, Wan X. TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis. The Journal of Experimental Medicine. PMID 31662347 DOI: 10.1084/jem.20182005  0.44
2019 Zhang G, Li X, Chen Q, Li J, Ruan Q, Chen YH, Yang X, Wan X. CD317 activates EGFR by regulating its association with lipid rafts. Cancer Research. PMID 30890618 DOI: 10.1158/0008-5472.CAN-18-2603  0.36
2018 Fan T, Zhong F, Liu R, Chen YH, Wang T, Ruan Q. siRNA-mediated c-Rel knockdown ameliorates collagen-induced arthritis in mice. International Immunopharmacology. 56: 9-17. PMID 29324391 DOI: 10.1016/j.intimp.2018.01.010  0.36
2017 Li J, Xie N, Yuan J, Liu L, Zhou Q, Ren X, Chen Q, Zhang G, Ruan Q, Chen YH, Wan X. DcR3 combined with hematological traits serves as a valuable biomarker for the diagnosis of cancer metastasis. Oncotarget. 8: 107612-107620. PMID 29296192 DOI: 10.18632/oncotarget.22544  0.36
2017 Zhang H, Bi J, Yi H, Fan T, Ruan Q, Cai L, Chen YH, Wan X. Silencing c-Rel in macrophages dampens Th1 and Th17 immune responses and alleviates experimental autoimmune encephalomyelitis in mice. Immunology and Cell Biology. PMID 28202908 DOI: 10.1038/icb.2017.11  0.36
2016 Li X, Zhang G, Chen Q, Lin Y, Li J, Ruan Q, Chen Y, Yu G, Wan X. CD317 Promotes the survival of cancer cells through apoptosis-inducing factor. Journal of Experimental & Clinical Cancer Research : Cr. 35: 117. PMID 27444183 DOI: 10.1186/s13046-016-0391-2  0.44
2016 Fan T, Wang S, Yu L, Yi H, Liu R, Geng W, Wan X, Ma Y, Cai L, Chen YH, Ruan Q. Treating psoriasis by targeting its susceptibility gene Rel. Clinical Immunology (Orlando, Fla.). PMID 26993753 DOI: 10.1016/j.clim.2016.03.009  0.36
2015 Sun H, Lou Y, Porturas T, Morrissey S, Luo G, Qi J, Ruan Q, Shi S, Chen YH. Exacerbated experimental colitis in TNFAIP8-deficient mice. Journal of Immunology (Baltimore, Md. : 1950). 194: 5736-42. PMID 25948814 DOI: 10.4049/jimmunol.1401986  0.44
2015 Porturas TP, Sun H, Buchlis G, Lou Y, Liang X, Cathopoulis T, Fayngerts S, Johnson DS, Wang Z, Chen YH. Crucial Roles of TNFAIP8 Protein in Regulating Apoptosis and Listeria Infection. Journal of Immunology (Baltimore, Md. : 1950). 194: 5743-50. PMID 25948813 DOI: 10.4049/jimmunol.1401987  0.44
2015 Zhang G, Zhao L, Wang Y, Shao J, Cui J, Lou Y, Geng M, Zhang N, Chen YH, Liu S. TIPE2 protein prevents injury-induced restenosis in mice. Biochimica Et Biophysica Acta. 1852: 1574-84. PMID 25912734 DOI: 10.1016/j.bbadis.2015.04.018  0.44
2015 Zhang Z, Liang X, Gao L, Ma H, Liu X, Pan Y, Yan W, Shan H, Wang Z, Chen YH, Ma C. TIPE1 induces apoptosis by negatively regulating Rac1 activation in hepatocellular carcinoma cells Oncogene. 34: 2566-2574. PMID 25043299 DOI: 10.1038/onc.2014.208  0.44
2014 Fayngerts SA, Wu J, Oxley CL, Liu X, Vourekas A, Cathopoulis T, Wang Z, Cui J, Liu S, Sun H, Lemmon MA, Zhang L, Shi Y, Chen YH. TIPE3 is the transfer protein of lipid second messengers that promote cancer. Cancer Cell. 26: 465-78. PMID 25242044 DOI: 10.1016/j.ccr.2014.07.025  0.44
2014 Lou Y, Sun H, Morrissey S, Porturas T, Liu S, Hua X, Chen YH. Critical roles of TIPE2 protein in murine experimental colitis. Journal of Immunology (Baltimore, Md. : 1950). 193: 1064-70. PMID 24973456 DOI: 10.4049/jimmunol.1400415  0.44
2014 Ruan Q, Wang P, Wang T, Qi J, Wei M, Wang S, Fan T, Johnson D, Wan X, Shi W, Sun H, Chen YH. MicroRNA-21 regulates T-cell apoptosis by directly targeting the tumor suppressor gene Tipe2. Cell Death & Disease. 5: e1095. PMID 24577093 DOI: 10.1038/cddis.2014.47  0.44
2013 Lou Y, Liu S, Zhang C, Zhang G, Li J, Ni M, An G, Dong M, Liu X, Zhu F, Zhang W, Gao F, Chen YH, Zhang Y. Enhanced atherosclerosis in TIPE2-deficient mice is associated with increased macrophage responses to oxidized low-density lipoprotein. Journal of Immunology (Baltimore, Md. : 1950). 191: 4849-57. PMID 24081993 DOI: 10.4049/jimmunol.1300053  0.44
2013 Zhang G, Zhang W, Lou Y, Xi W, Cui J, Geng M, Zhu F, Chen YH, Liu S. TIPE2 deficiency accelerates neointima formation by downregulating smooth muscle cell differentiation. Cell Cycle (Georgetown, Tex.). 12: 501-10. PMID 23324338 DOI: 10.4161/cc.23325  0.44
2012 Wang Z, Fayngerts S, Wang P, Sun H, Johnson DS, Ruan Q, Guo W, Chen YH. TIPE2 protein serves as a negative regulator of phagocytosis and oxidative burst during infection. Proceedings of the National Academy of Sciences of the United States of America. 109: 15413-8. PMID 22949657 DOI: 10.1073/pnas.1204525109  0.84
2012 Sun H, Zhuang G, Chai L, Wang Z, Johnson D, Ma Y, Chen YH. TIPE2 controls innate immunity to RNA by targeting the phosphatidylinositol 3-kinase-Rac pathway. Journal of Immunology (Baltimore, Md. : 1950). 189: 2768-73. PMID 22904303 DOI: 10.4049/jimmunol.1103477  0.44
2012 Yan Q, Carmody RJ, Qu Z, Ruan Q, Jager J, Mullican SE, Lazar MA, Chen YH. Nuclear factor-κB binding motifs specify Toll-like receptor-induced gene repression through an inducible repressosome. Proceedings of the National Academy of Sciences of the United States of America. 109: 14140-5. PMID 22891325 DOI: 10.1073/pnas.1119842109  0.36
2012 Zhang Y, Wei X, Liu L, Liu S, Wang Z, Zhang B, Fan B, Yang F, Huang S, Jiang F, Chen YH, Yi F. TIPE2, a novel regulator of immunity, protects against experimental stroke. The Journal of Biological Chemistry. 287: 32546-55. PMID 22859306 DOI: 10.1074/jbc.M112.348755  0.44
2012 Johnson DS, Chen YH. Ras family of small GTPases in immunity and inflammation. Current Opinion in Pharmacology. 12: 458-63. PMID 22401931 DOI: 10.1016/j.coph.2012.02.003  0.84
2012 Gus-Brautbar Y, Johnson D, Zhang L, Sun H, Wang P, Zhang S, Zhang L, Chen YH. The anti-inflammatory TIPE2 is an inhibitor of the oncogenic Ras. Molecular Cell. 45: 610-8. PMID 22326055 DOI: 10.1016/j.molcel.2012.01.006  0.44
2012 Ruan Q, Chen YH. Nuclear factor-κB in immunity and inflammation: the Treg and Th17 connection. Advances in Experimental Medicine and Biology. 946: 207-21. PMID 21948370 DOI: 10.1007/978-1-4614-0106-3_12  0.44
2011 Ruan Q, Kameswaran V, Zhang Y, Zheng S, Sun J, Wang J, DeVirgiliis J, Liou HC, Beg AA, Chen YH. The Th17 immune response is controlled by the Rel-RORγ-RORγ T transcriptional axis. The Journal of Experimental Medicine. 208: 2321-33. PMID 22006976 DOI: 10.1084/jem.20110462  0.44
2011 Chen YH. MicroRNA immunobiology: when microRNA chemists meet immunologists. Cellular & Molecular Immunology. 8: 369-70. PMID 21860407 DOI: 10.1038/cmi.2011.32  0.44
2011 Ruan Q, Wang T, Kameswaran V, Wei Q, Johnson DS, Matschinsky F, Shi W, Chen YH. The microRNA-21-PDCD4 axis prevents type 1 diabetes by blocking pancreatic beta cell death. Proceedings of the National Academy of Sciences of the United States of America. 108: 12030-5. PMID 21730150 DOI: 10.1073/pnas.1101450108  0.84
2011 Li L, Ruan Q, Hilliard B, Devirgiliis J, Karin M, Chen YH. Transcriptional regulation of the Th17 immune response by IKK(alpha). The Journal of Experimental Medicine. 208: 787-96. PMID 21402739 DOI: 10.1084/jem.20091346  0.36
2010 Ruan Q, Zheng SJ, Palmer S, Carmody RJ, Chen YH. Roles of Bcl-3 in the pathogenesis of murine type 1 diabetes. Diabetes. 59: 2549-57. PMID 20622172 DOI: 10.2337/db10-0480  0.36
2010 Cui M, Wang L, Liang X, Ma X, Liu Y, Yang M, Liu K, Wei X, Zhou Z, Chen YH, Sun W. Blocking TRAIL-DR5 signaling with soluble DR5 reduces delayed neuronal damage after transient global cerebral ischemia. Neurobiology of Disease. 39: 138-47. PMID 20359534 DOI: 10.1016/j.nbd.2010.03.018  0.44
2009 Ruan Q, Kameswaran V, Tone Y, Li L, Liou HC, Greene MI, Tone M, Chen YH. Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome. Immunity. 31: 932-40. PMID 20064450 DOI: 10.1016/j.immuni.2009.10.006  0.36
2009 Ludwinski MW, Sun J, Hilliard B, Gong S, Xue F, Carmody RJ, DeVirgiliis J, Chen YH. Critical roles of Bim in T cell activation and T cell-mediated autoimmune inflammation in mice. The Journal of Clinical Investigation. 119: 1706-13. PMID 19411758 DOI: 10.1172/JCI37619  0.44
2009 Razmara M, Hilliard B, Ziarani AK, Murali R, Yellayi S, Ghazanfar M, Chen YH, Tykocinski ML. Fn14-TRAIL, a chimeric intercellular signal exchanger, attenuates experimental autoimmune encephalomyelitis. The American Journal of Pathology. 174: 460-74. PMID 19147815 DOI: 10.2353/ajpath.2009.080462  0.44
2009 Zhang X, Wang J, Fan C, Li H, Sun H, Gong S, Chen YH, Shi Y. Crystal structure of TIPE2 provides insights into immune homeostasis. Nature Structural & Molecular Biology. 16: 89-90. PMID 19079267 DOI: 10.1038/nsmb.1522  0.44
2008 Li H, Zhang GX, Chen Y, Xu H, Fitzgerald DC, Zhao Z, Rostami A. CD11c+CD11b+ dendritic cells play an important role in intravenous tolerance and the suppression of experimental autoimmune encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950). 181: 2483-93. PMID 18684939 DOI: 10.4049/jimmunol.181.4.2483  0.44
2008 Sun H, Gong S, Carmody RJ, Hilliard A, Li L, Sun J, Kong L, Xu L, Hilliard B, Hu S, Shen H, Yang X, Chen YH. TIPE2, a Negative Regulator of Innate and Adaptive Immunity that Maintains Immune Homeostasis Cell. 133: 415-426. PMID 18455983 DOI: 10.1016/j.cell.2008.03.026  0.44
2008 Razmara M, Hilliard B, Ziarani AK, Chen YH, Tykocinski ML. CTLA-4 x Ig converts naive CD4+CD25- T cells into CD4+CD25+ regulatory T cells. International Immunology. 20: 471-83. PMID 18272926 DOI: 10.1093/intimm/dxn007  0.44
2007 Mays LE, Chen YH. Maintaining immunological tolerance with Foxp3. Cell Research. 17: 904-18. PMID 17923863 DOI: 10.1038/cr.2007.84  0.44
2007 Liang X, Du J, Liu Y, Cui M, Ma C, Han L, Qu Z, Zhang Z, Sun Z, Zhang L, Chen YH, Sun W. The hepatitis B virus protein MHBs(t) sensitizes hepatoma cells to TRAIL-induced apoptosis through ERK2. Apoptosis : An International Journal On Programmed Cell Death. 12: 1827-36. PMID 17701086 DOI: 10.1007/s10495-007-0114-4  0.44
2007 Carmody RJ, Ruan Q, Palmer S, Hilliard B, Chen YH. Negative regulation of toll-like receptor signaling by NF-kappaB p50 ubiquitination blockade. Science (New York, N.Y.). 317: 675-8. PMID 17673665 DOI: 10.1126/science.1142953  0.36
2007 Liang X, Liu Y, Zhang Q, Gao L, Han L, Ma C, Zhang L, Chen YH, Sun W. Hepatitis B virus sensitizes hepatocytes to TRAIL-induced apoptosis through Bax. Journal of Immunology (Baltimore, Md. : 1950). 178: 503-10. PMID 17182590  0.44
2007 Carmody RJ, Ruan Q, Liou HC, Chen YH. Essential roles of c-Rel in TLR-induced IL-23 p19 gene expression in dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 178: 186-91. PMID 17182554  0.36
2006 Hilliard A, Hilliard B, Zheng SJ, Sun H, Miwa T, Song W, Göke R, Chen YH. Translational regulation of autoimmune inflammation and lymphoma genesis by programmed cell death 4. Journal of Immunology (Baltimore, Md. : 1950). 177: 8095-102. PMID 17114484  0.44
2006 Anand S, Wang P, Yoshimura K, Choi IH, Hilliard A, Chen YH, Wang CR, Schulick R, Flies AS, Flies DB, Zhu G, Xu Y, Pardoll DM, Chen L, Tamada K. Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis. The Journal of Clinical Investigation. 116: 1045-51. PMID 16557300 DOI: 10.1172/JCI27083  0.44
2006 Carmody RJ, Maguschak K, Chen YH. A novel mechanism of nuclear factor-kappaB regulation by adenoviral protein 14.7K. Immunology. 117: 188-95. PMID 16423054 DOI: 10.1111/j.1365-2567.2005.02277.x  0.44
2005 Zheng SJ, Lamhamedi-Cherradi SE, Wang P, Xu L, Chen YH. Tumor suppressor p53 inhibits autoimmune inflammation and macrophage function. Diabetes. 54: 1423-8. PMID 15855329  0.36
2005 Finnberg N, Gruber JJ, Fei P, Rudolph D, Bric A, Kim SH, Burns TF, Ajuha H, Page R, Wu GS, Chen Y, McKenna WG, Bernhard E, Lowe S, Mak T, et al. DR5 knockout mice are compromised in radiation-induced apoptosis. Molecular and Cellular Biology. 25: 2000-13. PMID 15713653 DOI: 10.1128/MCB.25.5.2000-2013.2005  0.44
2004 Zheng SJ, Wang P, Tsabary G, Chen YH. Critical roles of TRAIL in hepatic cell death and hepatic inflammation. The Journal of Clinical Investigation. 113: 58-64. PMID 14702109 DOI: 10.1172/JCI19255  0.36
2003 Lamhamedi-Cherradi SE, Zheng S, Tisch RM, Chen YH. Critical roles of tumor necrosis factor-related apoptosis-inducing ligand in type 1 diabetes. Diabetes. 52: 2274-8. PMID 12941766 DOI: 10.2337/diabetes.52.9.2274  0.44
2003 Xu L, Hilliard B, Carmody RJ, Tsabary G, Shin H, Christianson DW, Chen YH. Arginase and autoimmune inflammation in the central nervous system. Immunology. 110: 141-8. PMID 12941151 DOI: 10.1046/j.1365-2567.2003.01713.x  0.44
2003 Mi QS, Ly D, Lamhamedi-Cherradi SE, Salojin KV, Zhou L, Grattan M, Meagher C, Zucker P, Chen YH, Nagle J, Taub D, Delovitch TL. Blockade of tumor necrosis factor-related apoptosis-inducing ligand exacerbates type 1 diabetes in NOD mice. Diabetes. 52: 1967-75. PMID 12882912 DOI: 10.2337/diabetes.52.8.1967  0.44
2003 Chen YH. Genes and genomics of autoimmune inflammation: from Rel to TRAIL. Immunologic Research. 27: 169-78. PMID 12857966 DOI: 10.1385/IR:27:2-3:169  0.44
2003 Lamhamedi-Cherradi SE, Zheng SJ, Maguschak KA, Peschon J, Chen YH. Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL-/- mice. Nature Immunology. 4: 255-60. PMID 12577054 DOI: 10.1038/ni894  0.44
2002 Carmody RJ, Hilliard B, Maguschak K, Chodosh LA, Chen YH. Genomic scale profiling of autoimmune inflammation in the central nervous system: the nervous response to inflammation. Journal of Neuroimmunology. 133: 95-107. PMID 12446012 DOI: 10.1016/S0165-5728(02)00366-1  0.44
1991 Takata M, Maiti PK, Bitoh S, Holford-Strevens V, Kierek-Jaszczuk D, Chen Y, Lang GM, Sehon AH. Downregulation of helper T cells by an antigen-specific monoclonal Ts factor. Cellular Immunology. 137: 139-49. PMID 1832086 DOI: 10.1016/0008-8749(91)90064-I  0.44
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