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Helmut Sies - Publications

Affiliations: 
1979-2008 Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Nordrhein-Westfalen, Germany 
Area:
Redox Biology, Oxidative Stress
Website:
https://nfcr.org/scientists/helmut-sies/
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67 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Cadenas E, Sies H. LESTER PACKER: ON HIS LIFE AND HIS LEGACY. Antioxidants & Redox Signaling. PMID 36006367 DOI: 10.1089/ars.2022.0097  0.43
2019 Sies H, Gerstenecker C, Menzel H, Flohé L. Oxidation in the NADP system and release of GSSG from hemoglobin-free perfused rat liver during peroxidatic oxidation of glutathione by hydroperoxides. Febs Letters. 27: 171-175. PMID 11946832 DOI: 10.1016/0014-5793(72)80434-4  0.419
2019 Sies H, Noack G. Proton movement accompanying monocarboxylate permeation in hemoglobin-free perfused rat liver. Febs Letters. 22: 193-196. PMID 11946594 DOI: 10.1016/0014-5793(72)80042-5  0.356
2005 Kálai T, Mugesh G, Roy G, Sies H, Berente Z, Hideg K. Combining benzo[d]isoselenazol-3-ones with sterically hindered alicyclic amines and nitroxides: enhanced activity as glutathione peroxidase mimics. Organic & Biomolecular Chemistry. 3: 3564-9. PMID 16172695 DOI: 10.1039/B509865C  0.688
2004 Packer L, Cadenas E, Frei B, Sies H. Special Issue Dedicated to Bruce Ames Archives of Biochemistry and Biophysics. 423: 1. DOI: 10.1016/j.abb.2003.12.010  0.365
2003 Mugesh G, Klotz LO, du Mont WW, Becker K, Sies H. Selenenyl iodide: a new substrate for mammalian thioredoxin reductase. Organic & Biomolecular Chemistry. 1: 2848-52. PMID 12968334 DOI: 10.1039/B302220J  0.513
2003 Jösch C, Klotz LO, Sies H. Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver. Biological Chemistry. 384: 213-8. PMID 12675513 DOI: 10.1515/BC.2003.023  0.304
2002 McKim SE, Konno A, Gäbele E, Uesugi T, Froh M, Sies H, Thurman RG, Arteel GE. Cocoa extract protects against early alcohol-induced liver injury in the rat. Archives of Biochemistry and Biophysics. 406: 40-6. PMID 12234488 DOI: 10.1016/S0003-9861(02)00425-3  0.441
2001 Mugesh G, du Mont WW, Sies H. Chemistry of biologically important synthetic organoselenium compounds. Chemical Reviews. 101: 2125-79. PMID 11710243 DOI: 10.1021/Cr000426W  0.474
2001 Kono H, Arteel GE, Rusyn I, Sies H, Thurman RG. Ebselen prevents early alcohol-induced liver injury in rats. Free Radical Biology & Medicine. 30: 403-11. PMID 11182296 DOI: 10.1016/S0891-5849(00)00490-1  0.459
2000 Cadenas E, Sies H. Formation of electronically excited states during the oxidation of arachidonic acid by prostaglandin endoperoxide synthase. Methods in Enzymology. 319: 67-77. PMID 10907500 DOI: 10.1016/S0076-6879(00)19009-3  0.511
1998 Cadenas E, Sies H. The lag phase. Free Radical Research. 28: 601-9. PMID 9736312 DOI: 10.3109/10715769809065816  0.47
1995 Akerboom TP, Sies H, Ziegler DM. The oxidation of ebselen metabolites to thiol oxidants catalyzed by liver microsomes and perfused rat liver. Archives of Biochemistry and Biophysics. 316: 220-6. PMID 7840620 DOI: 10.1006/ABBI.1995.1031  0.341
1989 Cadenas E, Simic MG, Sies H. Antioxidant activity of 5-hydroxytryptophan, 5-hydroxyindole, and DOPA against microsomal lipid peroxidation and its dependence on vitamin E. Free Radical Research Communications. 6: 11-7. PMID 2498167 DOI: 10.3109/10715768909073423  0.487
1988 Akerboom T, Bultmann T, Sies H. Inhibition of biliary taurocholate excretion during menadione metabolism in perfused rat liver. Archives of Biochemistry and Biophysics. 263: 10-8. PMID 3369854 DOI: 10.1016/0003-9861(88)90608-X  0.341
1988 Knoblauch AL, Paky A, Michael JR, Kutner ME, Cadenas E, Sies H, Adkinson NF, Gurtner GH. Hydroperoxide-induced chemiluminescence in rabbit lungs: role of arachidonic acid enzymes. Journal of Applied Physiology (Bethesda, Md. : 1985). 65: 1340-50. PMID 3141352 DOI: 10.1152/JAPPL.1988.65.3.1340  0.468
1985 Cadenas E, Sies H. Oxidative stress: excited oxygen species and enzyme activity. Advances in Enzyme Regulation. 23: 217-37. PMID 3907304 DOI: 10.1016/0065-2571(85)90049-4  0.527
1985 Sies H, Cadenas E. Oxidative stress: damage to intact cells and organs. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 311: 617-31. PMID 2869521 DOI: 10.1098/Rstb.1985.0168  0.534
1984 Cadenas E, Ginsberg M, Rabe U, Sies H. Evaluation of alpha-tocopherol antioxidant activity in microsomal lipid peroxidation as detected by low-level chemiluminescence. The Biochemical Journal. 223: 755-9. PMID 6508739 DOI: 10.1042/BJ2230755  0.458
1984 Müller A, Cadenas E, Graf P, Sies H. A novel biologically active seleno-organic compound--I. Glutathione peroxidase-like activity in vitro and antioxidant capacity of PZ 51 (Ebselen). Biochemical Pharmacology. 33: 3235-9. PMID 6487370 DOI: 10.1016/0006-2952(84)90083-2  0.524
1984 Cadenas E, Sies H. Low-level chemiluminescence as an indicator of singlet molecular oxygen in biological systems. Methods in Enzymology. 105: 221-31. PMID 6328183 DOI: 10.1016/S0076-6879(84)05029-1  0.48
1984 Cadenas E, Sies H, Graf P, Wefers H. Excited oxygen species, pyridine nucleotides and calcium transport Prostaglandins. 27: 3. DOI: 10.1016/0090-6980(84)90248-X  0.413
1983 Cadenas E, Brigelius R, Sies H. Paraquat-induced chemiluminescence of microsomal fractions. Biochemical Pharmacology. 32: 147-50. PMID 6830610 DOI: 10.1016/0006-2952(83)90667-6  0.53
1983 Cadenas E, Sies H, Graf H, Ullrich V. Oxene donors yield low-level chemiluminescence with microsomes and isolated cytochrome P-450. European Journal of Biochemistry / Febs. 130: 117-21. PMID 6825683 DOI: 10.1111/J.1432-1033.1983.Tb07125.X  0.491
1983 Cadenas E, Müller A, Brigelius R, Esterbauer H, Sies H. Effects of 4-hydroxynonenal on isolated hepatocytes. Studies on chemiluminescence response, alkane production and glutathione status. The Biochemical Journal. 214: 479-87. PMID 6688523 DOI: 10.1042/Bj2140479  0.52
1983 Crane D, Häussinger D, Graf P, Sies H. Decreased flux through pyruvate dehydrogenase by thiol oxidation during t-butyl hydroperoxide metabolism in perfused rat liver. Hoppe-Seyler's Zeitschrift Fã¼R Physiologische Chemie. 364: 977-87. PMID 6629333 DOI: 10.1515/BCHM2.1983.364.2.977  0.318
1983 Cadenas E, Sies H, Nastainczyk W, Ullrich V. Singlet oxygen formation detected by low-level chemiluminescence during enzymatic reduction of prostaglandin G2 to H2. Hoppe-Seyler's Zeitschrift Fã¼R Physiologische Chemie. 364: 519-28. PMID 6409778 DOI: 10.1515/Bchm2.1983.364.1.519  0.467
1983 Jernström B, Brigelius R, Sies H. Glutathione conjugation of benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-oxide in the perfused rat liver. Chemico-Biological Interactions. 44: 185-93. PMID 6406080 DOI: 10.1016/0009-2797(83)90139-4  0.303
1983 Sies H, Brigelius R, Wefers H, Müller A, Cadenas E. Cellular redox changes and response to drugs and toxic agents. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 3: 200-8. PMID 6354819 DOI: 10.1016/S0272-0590(83)80126-2  0.546
1983 Bartoli GM, Müller A, Cadenas E, Sies H. Antioxidant effect of diethyldithiocarbamate on microsomal lipid peroxidation assessed by low-level chemiluminescence and alkane production. Febs Letters. 164: 371-4. PMID 6317459 DOI: 10.1016/0014-5793(83)80319-6  0.469
1983 Wefers H, Sies H. Hepatic low-level chemiluminescence during redox cycling of menadione and the menadione-glutathione conjugate: relation to glutathione and NAD(P)H:quinone reductase (DT-diaphorase) activity. Archives of Biochemistry and Biophysics. 224: 568-78. PMID 6191666 DOI: 10.1016/0003-9861(83)90244-8  0.342
1983 Lengfelder E, Cadenas E, Sies H. Effect of DABCO (1,4-diazabicyclo[2,2,2]-octane) on singlet oxygen monomol (1270 nm) and dimol (634 and 703 nm) emission Febs Letters. 164: 366-370. DOI: 10.1016/0014-5793(83)80318-4  0.441
1982 Crane D, Häussinger D, Sies H. Rise of coenzyme A-glutathione mixed disulfide during hydroperoxide metabolism in perfused rat liver. European Journal of Biochemistry / Febs. 127: 575-8. PMID 7173198 DOI: 10.1111/J.1432-1033.1982.TB06911.X  0.311
1982 Cadenas E, Sies H. Low level chemiluminescence of liver microsomal fractions initiated by tert-butyl hydroperoxide. Relation to microsomal hemoproteins, oxygen dependence, and lipid peroxidation. European Journal of Biochemistry / Febs. 124: 349-56. PMID 7094917 DOI: 10.1111/J.1432-1033.1982.Tb06599.X  0.549
1982 Sies H, Akerboom TP, Cadenas E. The role of glutathione in hepatic hydroperoxide metabolism. Biochemical Society Transactions. 10: 79-80. PMID 7067916 DOI: 10.1042/Bst0100079  0.468
1982 Sies H, Graf P, Oshino N, Boveris A, Chance B. Peroxisomal function in perfused liver as studied by organ photometry. Annals of the New York Academy of Sciences. 386: 153-64. PMID 6124200 DOI: 10.1111/J.1749-6632.1982.Tb21413.X  0.365
1982 Bücher T, Sies H. Organ-photometric analysis of metabolic functions in subcellular compartments Fresenius' Zeitschrift FüR Analytische Chemie. 311: 315. DOI: 10.1007/Bf00481670  0.534
1981 Gerstenecker C, Sies H. Restriction of hexobarbital metabolism by t-butyl hydroperoxide in perfused rat liver. Biochemical Pharmacology. 29: 3112-3. PMID 7458966 DOI: 10.1016/0006-2952(80)90456-6  0.362
1981 Cadenas E, Wefers H, Sies H. Low-level chemiluminescence of isolated hepatocytes. European Journal of Biochemistry / Febs. 119: 531-6. PMID 7308199 DOI: 10.1111/J.1432-1033.1981.Tb05640.X  0.517
1981 Sies H, Wahlländer A, Waydhas C, Soboll S, Höberle D. Functions of intracellular glutathione in hepatic hydroperoxide and drug metabolism and the role of extracellular glutathione. Advances in Enzyme Regulation. 18: 303-20. PMID 7004130 DOI: 10.1016/0065-2571(80)90022-9  0.421
1979 Wahlländer A, Sies H. Glutathione S-conjugate formation from 1-chloro-2,4-dinitrobenzene and biliary S-conjugate excretion in the perfused rat liver. European Journal of Biochemistry. 96: 441-6. PMID 467417 DOI: 10.1111/J.1432-1033.1979.Tb13056.X  0.349
1979 Akerboom TP, Krietsch WK, Kuntz G, Sies H. Enzymatic measurement of adenine and guanine (plus inosine) triphosphates and diphosphates in isolated cells and the mitochondrial matrix compartment obtained from rat liver. Febs Letters. 105: 90-4. PMID 114422 DOI: 10.1016/0014-5793(79)80893-5  0.346
1979 Chance B, Sies H, Boveris A. Hydroperoxide metabolism in mammalian organs. Physiological Reviews. 59: 527-605. PMID 37532 DOI: 10.1152/Physrev.1979.59.3.527  0.302
1978 Sies H, Bartoli GM, Burk RF, Waydhas C. Glutathione efflux from perfused rat liver after phenobarbital treatment, during drug oxidations, and in selenium deficiency. European Journal of Biochemistry. 89: 113-8. PMID 699901 DOI: 10.1111/J.1432-1033.1978.Tb20902.X  0.456
1978 Sies H, Schwab H. Organ absorbance and fluorescence spectrophotometry and its application to oxygen-dependent parameters. Advances in Experimental Medicine and Biology. 94: 119-25. PMID 613754 DOI: 10.1007/978-1-4684-8890-6_17  0.364
1978 Waydhas C, Weigl K, Sies H. The disposition of formaldehyde and formate arising from drug N-demethylations dependent on cytochrome P-450 in hepatocytes and in perfused rat liver. European Journal of Biochemistry. 89: 143-50. PMID 568065 DOI: 10.1111/J.1432-1033.1978.Tb20906.X  0.39
1978 Sies H, Moss KM. A role of mitochondrial glutathione peroxidase in modulating mitochondrial oxidations in liver. European Journal of Biochemistry / Febs. 84: 377-83. PMID 25178 DOI: 10.1111/J.1432-1033.1978.Tb12178.X  0.398
1978 Bartoli GM, Sies H. Reduced and oxidized glutathione efflux from liver. Febs Letters. 86: 89-91. PMID 23318 DOI: 10.1016/0014-5793(78)80105-7  0.388
1977 Häussinger D, Weiss L, Sies H. Activation of pyruvate dehydrogenase during metabolism of ammonium ions in hemoglobin-free perfused rat liver. European Journal of Biochemistry. 52: 421-31. PMID 1236139 DOI: 10.1111/J.1432-1033.1975.Tb04010.X  0.432
1977 Sies H. Peroxisomal enzymes and oxygen metabolism in liver. Advances in Experimental Medicine and Biology. 78: 51-60. PMID 19943 DOI: 10.1007/978-1-4615-9035-4_4  0.404
1977 Weigl K, Sies H. Drug oxidations dependent on cytochrome P-450 in isolated hepatocytes. The role of the tricarboxylates and the aminotransferases in NADPH supply. European Journal of Biochemistry. 77: 401-8. PMID 19252 DOI: 10.1111/J.1432-1033.1977.Tb11680.X  0.417
1977 Sies H, Akerboom TP, Tager JM. Mitochondrial and cytosolic NADPH systems and isocitrate dehydrogenase indicator metabolites during ureogensis from ammonia in isolated rat hepatocytes. European Journal of Biochemistry. 72: 301-7. PMID 13998 DOI: 10.1111/J.1432-1033.1977.Tb11253.X  0.36
1975 Sies H. Oxidation of cytochrome b5 by hydroperoxides in rat liver. European Journal of Biochemistry. 57: 513-20. PMID 1175656 DOI: 10.1111/J.1432-1033.1975.Tb02326.X  0.398
1975 Sies H, Summer KH. Hydroperoxide-metabolizing systems in rat liver. European Journal of Biochemistry. 57: 503-12. PMID 1175655 DOI: 10.1111/J.1432-1033.1975.Tb02325.X  0.436
1975 Sies H, Summer KH, Bücher T. A process requiring mitochondrial NADPH: urea formation from ammonia. Febs Letters. 54: 274-8. PMID 236928 DOI: 10.1016/0014-5793(75)80091-3  0.537
1973 Sies H, Bücher T, Oshino N, Chance B. Heme occupancy of catalase in hemoglobin-free perfused rat liver and of isolated rat liver catalase. Archives of Biochemistry and Biophysics. 154: 106-16. PMID 4689773 DOI: 10.1016/0003-9861(73)90039-8  0.665
1973 Oshino N, Chance B, Sies H, Bücher T. The role of H 2 O 2 generation in perfused rat liver and the reaction of catalase compound I and hydrogen donors. Archives of Biochemistry and Biophysics. 154: 117-31. PMID 4347674 DOI: 10.1016/0003-9861(73)90040-4  0.657
1973 Oshino N, Chance B, Sies H. The properties of the secondary catalase—peroxide complex (Compound II) in the hemoglobin-free perfused rat liver Archives of Biochemistry and Biophysics. 159: 704-711. DOI: 10.1016/0003-9861(73)90510-9  0.465
1972 Sies H, Ta ST, Brauser B, Bücher T. Direct measurement of the state of the lactate dehydrogenase system in hemoglobin-free perfused rat liver. Advances in Enzyme Regulation. 10: 309-22. PMID 4653825 DOI: 10.1016/0065-2571(72)90020-9  0.63
1972 Sies H. The state of NADPH-NADP + during mixed-function oxidation of hexobarbital in hemoglobin-free perfused rat liver. Chemico-Biological Interactions. 3: 308-9. PMID 4399906 DOI: 10.1016/0009-2797(71)90073-1  0.302
1972 Bücher T, Brauser B, Conze A, Klein F, Langguth O, Sies H. State of oxidation-reduction and state of binding in the cytosolic NADH-system as disclosed by equilibration with extracellular lactate-pyruvate in hemoglobin-free perfused rat liver. European Journal of Biochemistry / Febs. 27: 301-17. PMID 4340564  0.58
1970 Sies H, Kandel M. Positive increase of redox potential of the extramitochondrial NADP(H) system by mixed function oxidations in hemoglobin-free perfused rat liver. Febs Letters. 9: 205-208. PMID 11947671 DOI: 10.1016/0014-5793(70)80356-8  0.395
1970 Sies H, Chance B. The steady state level of catalase compound I in isolated hemoglobin-free perfused rat liver. Febs Letters. 11: 172-176. PMID 11945479 DOI: 10.1016/0014-5793(70)80521-X  0.514
1969 Sies H, Brauser B, Bücher T. On the state of mitochondria in perfused liver: Action of sodium azide on respiratory carriers and respiration. Febs Letters. 5: 319-323. PMID 11947307 DOI: 10.1016/0014-5793(69)80346-7  0.602
1969 Brauser B, Sies H, Bücher T. Action of amobarbital on microsomal and mitochondrial respiratory state in perfused rat liver with and without phenobarbital induction. Febs Letters. 2: 170-172. PMID 11946302 DOI: 10.1016/0014-5793(69)80009-8  0.605
1969 Brauser B, Sies H, Bücher T. Reduction kinetics and content of cytochrome P-450 by application of dual wavelength techniques to hemoglobin-free perfused rat liver. Febs Letters. 2: 167-169. PMID 11946301 DOI: 10.1016/0014-5793(69)80008-6  0.579
1969 Bücher T, Sies H. Steady state relaxation of enolase in vitro and metabolic throughput in vivo of red and white rabbit muscles. European Journal of Biochemistry / Febs. 8: 273-83. PMID 5781277 DOI: 10.1111/J.1432-1033.1969.Tb00524.X  0.561
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