| Year |
Citation |
Score |
| 2024 |
Ajiboye J, Uldry AC, Heller M, Naguleswaran A, Fan E, Van Voorhis WC, Hemphill A, Müller J. Molecular Targets of the 5-Amido-Carboxamide Bumped Kinase Inhibitor BKI-1748 in and HCT-8 Host Cells. International Journal of Molecular Sciences. 25. PMID 38473953 DOI: 10.3390/ijms25052707 |
0.308 |
|
| 2017 |
Jiménez-Meléndez A, Ojo KK, Wallace AM, Smith TR, Hemphill A, Balmer V, Regidor-Cerrillo J, Ortega-Mora LM, Hehl AB, Fan E, Maly DJ, Van Voorhis WC, Álvarez-García G. In vitro efficacy of bumped kinase inhibitors against Besnoitia besnoiti tachyzoites. International Journal For Parasitology. PMID 28899692 DOI: 10.1016/J.Ijpara.2017.08.005 |
0.309 |
|
| 2016 |
Ojo KK, Dangoudoubiyam S, Verma SK, Scheele S, DeRocher AE, Yeargan M, Choi R, Smith TR, Rivas KL, Hulverson MA, Barrett LK, Fan E, Maly DJ, Parsons M, Dubey JP, ... ... Van Voorhis WC, et al. Selective inhibition of Sarcocystis neurona calcium-cependent protein kinase 1 for equine protozoal myeloencephalitis therapy. International Journal For Parasitology. PMID 27729271 DOI: 10.1016/J.Ijpara.2016.08.003 |
0.33 |
|
| 2016 |
Vidadala RS, Rivas KL, Ojo KK, Hulverson MA, Zambriski JA, Bruzual I, Schultz TL, Huang W, Zhang Z, Scheele S, DeRocher AE, Choi R, Barrett LK, Siddaramaiah LK, Hol WG, ... ... Van Voorhis WC, et al. Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis. Journal of Medicinal Chemistry. 59: 6531-46. PMID 27309760 DOI: 10.1021/Acs.Jmedchem.6B00760 |
0.309 |
|
| 2015 |
Winzer P, Müller J, Aguado-Martínez A, Rahman M, Balmer V, Manser V, Ortega-Mora LM, Ojo KK, Fan E, Maly DJ, Van Voorhis WC, Hemphill A. In Vitro and In Vivo Effects of the Bumped Kinase Inhibitor 1294 in the Related Cyst-Forming Apicomplexans Toxoplasma gondii and Neospora caninum. Antimicrobial Agents and Chemotherapy. 59: 6361-74. PMID 26248379 DOI: 10.1128/Aac.01236-15 |
0.307 |
|
| 2015 |
Hines SA, Ramsay JD, Kappmeyer LS, Lau AO, Ojo KK, Van Voorhis WC, Knowles DP, Mealey RH. Theileria equi isolates vary in susceptibility to imidocarb dipropionate but demonstrate uniform in vitro susceptibility to a bumped kinase inhibitor. Parasites & Vectors. 8: 33. PMID 25600252 DOI: 10.1186/S13071-014-0611-6 |
0.33 |
|
| 2014 |
Ojo KK, Eastman RT, Vidadala R, Zhang Z, Rivas KL, Choi R, Lutz JD, Reid MC, Fox AM, Hulverson MA, Kennedy M, Isoherranen N, Kim LM, Comess KM, Kempf DJ, ... ... Van Voorhis WC, et al. A specific inhibitor of PfCDPK4 blocks malaria transmission: chemical-genetic validation. The Journal of Infectious Diseases. 209: 275-84. PMID 24123773 DOI: 10.1093/Infdis/Jit522 |
0.693 |
|
| 2012 |
Johnson SM, Murphy RC, Geiger JA, DeRocher AE, Zhang Z, Ojo KK, Larson ET, Perera BG, Dale EJ, He P, Reid MC, Fox AM, Mueller NR, Merritt EA, Fan E, ... ... Van Voorhis WC, et al. Development of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) inhibitors with potent anti-toxoplasma activity. Journal of Medicinal Chemistry. 55: 2416-26. PMID 22320388 DOI: 10.1021/Jm201713H |
0.301 |
|
| 2011 |
Shibata S, Gillespie JR, Kelley AM, Napuli AJ, Zhang Z, Kovzun KV, Pefley RM, Lam J, Zucker FH, Van Voorhis WC, Merritt EA, Hol WG, Verlinde CL, Fan E, Buckner FS. Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in Mice. Antimicrobial Agents and Chemotherapy. 55: 1982-9. PMID 21282428 DOI: 10.1128/Aac.01796-10 |
0.341 |
|
| 2008 |
Ojo KK, Gillespie JR, Riechers AJ, Napuli AJ, Verlinde CL, Buckner FS, Gelb MH, Domostoj MM, Wells SJ, Scheer A, Wells TN, Van Voorhis WC. Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy. Antimicrobial Agents and Chemotherapy. 52: 3710-7. PMID 18644955 DOI: 10.1128/Aac.00364-08 |
0.33 |
|
| 2008 |
Arakaki TL, Buckner FS, Gillespie JR, Malmquist NA, Phillips MA, Kalyuzhniy O, Luft JR, Detitta GT, Verlinde CL, Van Voorhis WC, Hol WG, Merritt EA. Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies. Molecular Microbiology. 68: 37-50. PMID 18312275 DOI: 10.1111/J.1365-2958.2008.06131.X |
0.332 |
|
| 2008 |
Yokoyama K, Gillespie JR, Van Voorhis WC, Buckner FS, Gelb MH. Protein geranylgeranyltransferase-I of Trypanosoma cruzi. Molecular and Biochemical Parasitology. 157: 32-43. PMID 17996962 DOI: 10.1016/J.Molbiopara.2007.09.006 |
0.346 |
|
| 2007 |
Gillespie JR, Yokoyama K, Lu K, Eastman RT, Bollinger JG, Van Voorhis WC, Gelb MH, Buckner FS. C-terminal proteolysis of prenylated proteins in trypanosomatids and RNA interference of enzymes required for the post-translational processing pathway of farnesylated proteins. Molecular and Biochemical Parasitology. 153: 115-24. PMID 17397944 DOI: 10.1016/J.Molbiopara.2007.02.009 |
0.639 |
|
| 2007 |
Eastman RT, White J, Hucke O, Yokoyama K, Verlinde CL, Hast MA, Beese LS, Gelb MH, Rathod PK, Van Voorhis WC. Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase. Molecular and Biochemical Parasitology. 152: 66-71. PMID 17208314 DOI: 10.1016/J.Molbiopara.2006.11.012 |
0.634 |
|
| 2006 |
Centurion-Lara A, Molini BJ, Godornes C, Sun E, Hevner K, Van Voorhis WC, Lukehart SA. Molecular differentiation of Treponema pallidum subspecies. Journal of Clinical Microbiology. 44: 3377-80. PMID 16954278 DOI: 10.1128/Jcm.00784-06 |
0.702 |
|
| 2006 |
Eastman RT, Buckner FS, Yokoyama K, Gelb MH, Van Voorhis WC. Fighting parasitic disease by blocking protein farnesylation Journal of Lipid Research. 47: 233-240. PMID 16339110 DOI: 10.1194/Jlr.R500016-Jlr200 |
0.634 |
|
| 2005 |
Eastman RT, Barrett LK, Dupuis K, Buckner FS, Van Voorhis WC. Leishmania inactivation in human pheresis platelets by a psoralen (amotosalen HCl) and long-wavelength ultraviolet irradiation Transfusion. 45: 1459-1463. PMID 16131378 DOI: 10.1111/J.1537-2995.2005.00552.X |
0.591 |
|
| 2005 |
Buckner FS, Eastman RT, Yokoyama K, Gelb MH, Van Voorhis WC. Protein farnesyl transferase inhibitors for the treatment of malaria and African trypanosomiasis Current Opinion in Investigational Drugs. 6: 791-797. PMID 16121685 |
0.672 |
|
| 2005 |
Eastman RT, White J, Hucke O, Bauer K, Yokoyama K, Nallan L, Chakrabarti D, Verlinde CL, Gelb MH, Rathod PK, Van Voorhis WC. Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum. The Journal of Biological Chemistry. 280: 13554-9. PMID 15661734 DOI: 10.1074/Jbc.M413556200 |
0.639 |
|
| 2005 |
Vigna KL, Hucke O, Eastman R, Verlinde CL, Van Voorhis WC. 314 MOLECULAR MODELING OF FARNESYLTRANSFERASE INHIBITORS FOR MALARIA THERAPEUTICS Journal of Investigative Medicine. 53: S133.3-S133. DOI: 10.2310/6650.2005.00005.313 |
0.641 |
|
| 2004 |
Giacani L, Sun ES, Hevner K, Molini BJ, Van Voorhis WC, Lukehart SA, Centurion-Lara A. Tpr homologs in Treponema paraluiscuniculi Cuniculi A strain. Infection and Immunity. 72: 6561-76. PMID 15501788 DOI: 10.1128/Iai.72.11.6561-6576.2004 |
0.738 |
|
| 2004 |
Sun ES, Molini BJ, Barrett LK, Centurion-Lara A, Lukehart SA, Van Voorhis WC. Subfamily I Treponema pallidum repeat protein family: sequence variation and immunity. Microbes and Infection / Institut Pasteur. 6: 725-37. PMID 15207819 DOI: 10.1016/J.Micinf.2004.04.001 |
0.737 |
|
| 2004 |
Ohkanda J, Buckner FS, Lockman JW, Yokoyama K, Carrico D, Eastman R, de Luca-Fradley K, Davies W, Croft SL, Van Voorhis WC, Gelb MH, Sebti SM, Hamilton AD. Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents. Journal of Medicinal Chemistry. 47: 432-45. PMID 14711313 DOI: 10.1021/Jm030236O |
0.64 |
|
| 2003 |
Buckner F, Yokoyama K, Lockman J, Aikenhead K, Ohkanda J, Sadilek M, Sebti S, Van Voorhis W, Hamilton A, Gelb MH. A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents. Proceedings of the National Academy of Sciences of the United States of America. 100: 15149-53. PMID 14657358 DOI: 10.1073/Pnas.2535442100 |
0.344 |
|
| 2003 |
Leader BT, Hevner K, Molini BJ, Barrett LK, Van Voorhis WC, Lukehart SA. Antibody responses elicited against the Treponema pallidum repeat proteins differ during infection with different isolates of Treponema pallidum subsp. pallidum. Infection and Immunity. 71: 6054-7. PMID 14500529 DOI: 10.1128/Iai.71.10.6054-6057.2003 |
0.311 |
|
| 2003 |
Morgan CA, Lukehart SA, Van Voorhis WC. Protection against syphilis correlates with specificity of antibodies to the variable regions of Treponema pallidum repeat protein K. Infection and Immunity. 71: 5605-12. PMID 14500480 DOI: 10.1128/Iai.71.10.5605-5612.2003 |
0.535 |
|
| 2003 |
Gelb MH, Van Voorhis WC, Buckner FS, Yokoyama K, Eastman R, Carpenter EP, Panethymitaki C, Brown KA, Smith DF. Protein farnesyl and N-myristoyl transferases: Piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics Molecular and Biochemical Parasitology. 126: 155-163. PMID 12615314 DOI: 10.1016/S0166-6851(02)00282-7 |
0.646 |
|
| 2003 |
Van Voorhis WC, Barrett LK, Eastman RT, Alfonso R, Dupuis K. Trypanosoma cruzi inactivation in human platelet concentrates and plasma by a psoralen (Amotosalen HCl) and long-wavelength UV Antimicrobial Agents and Chemotherapy. 47: 475-479. PMID 12543646 DOI: 10.1128/Aac.47.2.475-479.2003 |
0.608 |
|
| 2002 |
Morgan CA, Lukehart SA, Van Voorhis WC. Immunization with the N-terminal portion of Treponema pallidum repeat protein K attenuates syphilitic lesion development in the rabbit model. Infection and Immunity. 70: 6811-6. PMID 12438357 DOI: 10.1128/Iai.70.12.6811-6816.2002 |
0.559 |
|
| 2002 |
Buckner FS, Kateete DP, Lubega GW, Van Voorhis WC, Yokoyama K. Trypanosoma brucei prenylated-protein carboxyl methyltransferase prefers farnesylated substrates Biochemical Journal. 367: 809-816. PMID 12141948 DOI: 10.1042/BJ20020277 |
0.33 |
|
| 2002 |
Buckner FS, Eastman RT, Nepomuceno-Silva JL, Speelmon EC, Myler PJ, Van Voorhis WC, Yokoyama K. Cloning, heterologous expression, and substrate specificities of protein farnesyltransferases from Trypanosoma cruzi and Leishmania major. Molecular and Biochemical Parasitology. 122: 181-8. PMID 12106872 DOI: 10.1016/S0166-6851(02)00099-3 |
0.664 |
|
| 2002 |
Morgan CA, Molini BJ, Lukehart SA, Van Voorhis WC. Segregation of B and T cell epitopes of Treponema pallidum repeat protein K to variable and conserved regions during experimental syphilis infection. Journal of Immunology (Baltimore, Md. : 1950). 169: 952-7. PMID 12097401 DOI: 10.4049/Jimmunol.169.2.952 |
0.565 |
|
| 2000 |
Centurion-Lara A, Sun ES, Barrett LK, Castro C, Lukehart SA, Van Voorhis WC. Multiple alleles of Treponema pallidum repeat gene D in Treponema pallidum isolates. Journal of Bacteriology. 182: 2332-5. PMID 10735882 DOI: 10.1128/Jb.182.8.2332-2335.2000 |
0.711 |
|
| 1999 |
Weston D, Patel B, Van Voorhis WC. Virulence in Trypanosoma cruzi infection correlates with the expression of a distinct family of sialidase superfamily genes Molecular and Biochemical Parasitology. 98: 105-116. PMID 10029313 DOI: 10.1016/S0166-6851(98)00152-2 |
0.306 |
|
| 1999 |
Centurion-Lara A, Castro C, Barrett L, Cameron C, Mostowfi M, Van Voorhis WC, Lukehart SA. Treponema pallidum major sheath protein homologue Tpr K is a target of opsonic antibody and the protective immune response Journal of Experimental Medicine. 189: 647-656. PMID 9989979 DOI: 10.1084/Jem.189.4.647 |
0.314 |
|
| 1998 |
Cameron CE, Castro C, Lukehart SA, Van Voorhis WC. Function and protective capacity of Treponema pallidum subsp. pallidum Glycerophosphodiester phosphodiesterase Infection and Immunity. 66: 5763-5770. PMID 9826352 DOI: 10.1128/Iai.66.12.5763-5770.1998 |
0.332 |
|
| 1998 |
Yokoyama K, Trobridge P, Buckner FS, Van Voorhis WC, Stuart KD, Gelb MH. Protein farnesyltransferase from Trypanosoma brucei. A heterodimer of 61- and 65-kDa subunits as a new target for antiparasite therapeutics Journal of Biological Chemistry. 273: 26497-26505. PMID 9756885 DOI: 10.1074/Jbc.273.41.26497 |
0.362 |
|
| 1998 |
Yokoyama K, Trobridge P, Buckner FS, Scholten J, Stuart KD, Van Voorhis WC, Gelb MH. The effects of protein farnesyltransferase inhibitors on trypanosomatids: Inhibition of protein farnesylation and cell growth Molecular and Biochemical Parasitology. 94: 87-97. PMID 9719512 DOI: 10.1016/S0166-6851(98)00053-X |
0.328 |
|
| 1997 |
Buckner FS, Wipke BT, Van Voorhis WC. Trypanosoma cruzi infection does not impair major histocompatibility complex class I presentation of antigen to cytotoxic T lymphocytes European Journal of Immunology. 27: 2541-2548. PMID 9368608 DOI: 10.1002/eji.1830271012 |
0.305 |
|
| 1997 |
Centurion-Lara A, Arroll T, Castillo R, Shaffer JM, Castro C, Van Voorhis WC, Lukehart SA. Conservation of the 15-kilodalton lipoprotein among Treponema pallidum subspecies and strains and other pathogenic treponemes: Genetic and antigenic analyses Infection and Immunity. 65: 1440-1444. PMID 9119485 DOI: 10.1128/Iai.65.4.1440-1444.1997 |
0.331 |
|
| 1993 |
Cetron MS, Basilio FP, Moraes AP, Sousa AQ, Paes JN, Kahn SJ, Wener MH, Van Voorhis WC. Humoral and cellular immune response of adults from northeastern Brazil with chronic Trypanosoma cruzi infection: Depressed cellular immune response to T. cruzi antigen among Chagas' disease patients with symptomatic versus indeterminate infection American Journal of Tropical Medicine and Hygiene. 49: 370-382. PMID 8372959 |
0.306 |
|
| 1992 |
Cetron MS, Hoff R, Kahn S, Eisen H, Van Voorhis WC. Evaluation of recombinant trypomastigote surface antigens of Trypanosoma cruzi in screening sera from a population in rural northeastern Brazil endemic for Chagas' disease. Acta Tropica. 50: 259-66. PMID 1348602 DOI: 10.1016/0001-706X(92)90082-9 |
0.319 |
|
| 1983 |
Kaplan G, Van Voorhis WC, Sarno EN, Nogueira N, Cohn ZA. The cutaneous infiltrates of leprosy. A transmission electron microscopy study. The Journal of Experimental Medicine. 158: 1145-59. PMID 6352848 DOI: 10.1084/Jem.158.4.1145 |
0.476 |
|
| 1983 |
Inaba K, Steinman RM, Van Voorhis WC, Muramatsu S. Dendritic cells are critical accessory cells for thymus-dependent antibody responses in mouse and in man Proceedings of the National Academy of Sciences of the United States of America. 80: 6041-6045. PMID 6351074 |
0.469 |
|
| 1983 |
Van Voorhis WC, Valinsky J, Hoffman E, Luban J, Hair LS, Steinman RM. Relative efficacy of human monocytes and dendritic cells as accessory cells for T cell replication. The Journal of Experimental Medicine. 158: 174-91. PMID 6190976 DOI: 10.1084/Jem.158.1.174 |
0.446 |
|
| 1983 |
Van Voorhis WC, Steinman RM, Hair LS, Luban J, Witmer MD, Koide S, Cohn ZA. Specific antimononuclear phagocyte monoclonal antibodies. Application to the purification of dendritic cells and the tissue localization of macrophages. The Journal of Experimental Medicine. 158: 126-45. PMID 6190974 DOI: 10.1084/Jem.158.1.126 |
0.584 |
|
| 1982 |
Van Voorhis WC, Kaplan G, Sarno EN, Horwitz MA, Steinman RM, Levis WR, Nogueira N, Hair LS, Gattass CR, Arrick BA, Cohn ZA. The cutaneous infiltrates of leprosy: cellular characteristics and the predominant T-cell phenotypes. The New England Journal of Medicine. 307: 1593-7. PMID 6216407 DOI: 10.1056/Nejm198212233072601 |
0.599 |
|
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