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Daniel Peter Perl, MD, Columbia University - Publications

Affiliations: 
Pathology Icahn School of Medicine at Mount Sinai, New York, NY, United States 
Area:
Environmental Factors in Neurodegenerative Disease
Website:
http://www.mssm.edu/profiles/daniel-p-perl

140 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Kovacs GG, Robinson JL, Perl DP, Lee VM, Trojanowski JQ. Thorn-shaped astrocytes in the depth of cortical sulci in Western Pacific ALS/Parkinsonism-Dementia complex. Acta Neuropathologica. PMID 32662040 DOI: 10.1007/S00401-020-02192-0  0.322
2019 Iacono D, Lee P, Edlow BL, Gray N, Fischl B, Kenney K, Lew HL, Lozanoff S, Liacouras P, Lichtenberger J, Dams-O'Connor K, Cifu D, Hinds SR, Perl DP. Early-Onset Dementia in War Veterans: Brain Polypathology and Clinicopathologic Complexity. Journal of Neuropathology and Experimental Neurology. PMID 31851313 DOI: 10.1093/Jnen/Nlz122  0.402
2018 Iacono D, Lee P, Hallett M, Perl D. Possible Post-Traumatic Focal Dystonia Associated with Tau Pathology Localized to Putamen-Globus Pallidus. Movement Disorders Clinical Practice. 5: 492-498. PMID 30637269 DOI: 10.1002/Mdc3.12626  0.329
2018 Munger EL, Edler MK, Hopkins WD, Ely JJ, Erwin JM, Perl DP, Mufson EJ, Hof PR, Sherwood CC, Raghanti MA. Astrocytic changes with aging and Alzheimer's disease-type pathology in chimpanzees. The Journal of Comparative Neurology. PMID 30578640 DOI: 10.1002/Cne.24610  0.393
2018 Snyder HM, Carare RO, DeKosky ST, de Leon MJ, Dykxhoorn D, Gan L, Gardner R, Hinds SR, Jaffee M, Lamb BT, Landau S, Manley G, McKee A, Perl D, Schneider JA, et al. Military-related risk factors for dementia. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30415806 DOI: 10.1016/J.Jalz.2018.08.011  0.374
2018 Edler MK, Sherwood CC, Meindl RS, Munger E, Hopkins WD, Ely JJ, Erwin JM, Perl DP, Mufson EJ, Hof PR, Raghanti MA. Microglia changes associated to Alzheimer's disease pathology in aged chimpanzees. The Journal of Comparative Neurology. PMID 30069930 DOI: 10.1002/Cne.24484  0.397
2018 Edlow BL, Keene CD, Perl D, Iacono D, Folkerth R, Stewart W, MacDonald CL, Augustinack J, Diaz-Arrastia R, Estrada C, Flannery E, Gordon W, Grabowski T, Hansen K, Hoffman J, et al. Multimodal Characterization of the Late Effects of TBI (LETBI): A Methodological Overview of the LETBI Project. Journal of Neurotrauma. PMID 29421973 DOI: 10.1089/Neu.2017.5457  0.402
2017 Kenney K, Iacono D, Edlow BL, Katz DI, Diaz-Arrastia R, Dams-O'Connor K, Daneshvar DH, Stevens A, Moreau AL, Tirrell LS, Varjabedian A, Yendiki A, van der Kouwe A, Mareyam A, McNab JA, ... ... Perl DP, et al. Dementia After Moderate-Severe Traumatic Brain Injury: Coexistence of Multiple Proteinopathies. Journal of Neuropathology and Experimental Neurology. PMID 29155947 DOI: 10.1093/Jnen/Nlx101  0.423
2017 Iacono D, Shively SB, Edlow BL, Perl DP. Chronic Traumatic Encephalopathy: Known Causes, Unknown Effects. Physical Medicine and Rehabilitation Clinics of North America. 28: 301-321. PMID 28390515 DOI: 10.1016/J.Pmr.2016.12.007  0.35
2017 Dugger BN, Perl DP, Carlson GA. Neurodegenerative Disease Transmission and Transgenesis in Mice. Cold Spring Harbor Perspectives in Biology. 9. PMID 28193724 DOI: 10.1101/Cshperspect.A023549  0.352
2017 Perl D. Dementia Resulting From Traumatic Brain Injury Alzheimers & Dementia. 13: 170. DOI: 10.1016/J.Jalz.2017.07.008  0.303
2016 Shively SB, Edgerton SL, Iacono D, Purohit DP, Qu BX, Haroutunian V, Davis KL, Diaz-Arrastia R, Perl DP. Localized cortical chronic traumatic encephalopathy pathology after single, severe axonal injury in human brain. Acta Neuropathologica. PMID 27885490 DOI: 10.1007/S00401-016-1649-7  0.375
2015 McKee AC, Cairns NJ, Dickson DW, Folkerth RD, Dirk Keene C, Litvan I, Perl DP, Stein TD, Vonsattel JP, Stewart W, Tripodis Y, Crary JF, Bieniek KF, Dams-O'Connor K, Alvarez VE, et al. The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy. Acta Neuropathologica. PMID 26667418 DOI: 10.1007/S00401-015-1515-Z  0.439
2014 Kenney K, Massetti S, Shively S, Diaz-Arrastia R, Perl D. Clinicopathological Correlation Of A Case Of Dementia After Tbi Alzheimers & Dementia. 10: 843. DOI: 10.1016/J.Jalz.2014.05.1664  0.318
2012 Shively S, Scher AI, Perl DP, Diaz-Arrastia R. Dementia resulting from traumatic brain injury: what is the pathology? Archives of Neurology. 69: 1245-51. PMID 22776913 DOI: 10.1001/Archneurol.2011.3747  0.363
2012 Beeri MS, Schmeidler J, Lesser GT, Maroukian M, West R, Leung S, Wysocki M, Perl DP, Purohit DP, Haroutunian V. Corticosteroids, but not NSAIDs, are associated with less Alzheimer neuropathology. Neurobiology of Aging. 33: 1258-64. PMID 21458888 DOI: 10.1016/J.Neurobiolaging.2011.02.011  0.35
2011 Purohit DP, Batheja NO, Sano M, Jashnani KD, Kalaria RN, Karunamurthy A, Kaur S, Shenoy AS, Van Dyk K, Schmeidler J, Perl DP. Profiles of Alzheimer's disease-related pathology in an aging urban population sample in India. Journal of Alzheimer's Disease : Jad. 24: 187-96. PMID 21187583 DOI: 10.3233/Jad-2010-101698  0.4
2010 McKee AC, Gavett BE, Stern RA, Nowinski CJ, Cantu RC, Kowall NW, Perl DP, Hedley-Whyte ET, Price B, Sullivan C, Morin P, Lee HS, Kubilus CA, Daneshvar DH, Wulff M, et al. TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy. Journal of Neuropathology and Experimental Neurology. 69: 918-29. PMID 20720505 DOI: 10.1097/Nen.0B013E3181Ee7D85  0.373
2010 Takahashi H, Brasnjevic I, Rutten BP, Van Der Kolk N, Perl DP, Bouras C, Steinbusch HW, Schmitz C, Hof PR, Dickstein DL. Hippocampal interneuron loss in an APP/PS1 double mutant mouse and in Alzheimer's disease. Brain Structure & Function. 214: 145-60. PMID 20213270 DOI: 10.1007/S00429-010-0242-4  0.359
2010 Perl DP. Neuropathology of Alzheimer's disease. The Mount Sinai Journal of Medicine, New York. 77: 32-42. PMID 20101720 DOI: 10.1002/Msj.20157  0.456
2010 West B, McKee AC, Sano M, Perl DP. P1-199: Alzheimer's disease and chronic traumatic encephalopathy: An overlapping pathological picture? Alzheimer's & Dementia. 6: S231-S231. DOI: 10.1016/J.Jalz.2010.05.749  0.384
2009 Libow LS, Frisina PG, Haroutunian V, Perl DP, Purohit DP. Parkinson's disease dementia: a diminished role for the Lewy body. Parkinsonism & Related Disorders. 15: 572-5. PMID 19346154 DOI: 10.1016/J.Parkreldis.2009.02.003  0.414
2009 Boyd JL, Casson I, DeKosky S, Feuer H, Gandy S, Khachaturian Z, Kinoshita J, Marchesi V, McKee A, Nowinski C, Perl D, Purohit D, Relkin N, Smith MA, Strobel G, et al. Alzheimer research forum live discussion: Sports concussions, dementia, and ApoE genotyping: What can scientists tell the public? What's up for research? Journal of Alzheimer's Disease. 16: 657-666. PMID 19276560 DOI: 10.3233/Jad-2009-1014  0.311
2009 Beeri MS, Rapp M, Schmeidler J, Reichenberg A, Purohit DP, Perl DP, Grossman HT, Prohovnik I, Haroutunian V, Silverman JM. Number of children is associated with neuropathology of Alzheimer's disease in women. Neurobiology of Aging. 30: 1184-91. PMID 18079025 DOI: 10.1016/J.Neurobiolaging.2007.11.011  0.313
2008 Haroutunian V, Schnaider-Beeri M, Schmeidler J, Wysocki M, Purohit DP, Perl DP, Libow LS, Lesser GT, Maroukian M, Grossman HT. Role of the neuropathology of Alzheimer disease in dementia in the oldest-old. Archives of Neurology. 65: 1211-7. PMID 18779425 DOI: 10.1001/Archneur.65.9.1211  0.376
2008 Schnaider Beeri M, Silverman JM, Schmeidler J, Wysocki M, Grossman HZ, Purohit DP, Perl DP, Haroutunian V. Clinical dementia rating performed several years prior to death predicts regional Alzheimer's neuropathology. Dementia and Geriatric Cognitive Disorders. 25: 392-8. PMID 18367838 DOI: 10.1159/000122586  0.373
2008 Rapp MA, Schnaider-Beeri M, Purohit DP, Perl DP, Haroutunian V, Sano M. Increased neurofibrillary tangles in patients with Alzheimer disease with comorbid depression. The American Journal of Geriatric Psychiatry : Official Journal of the American Association For Geriatric Psychiatry. 16: 168-74. PMID 18239198 DOI: 10.1097/Jgp.0B013E31816029Ec  0.366
2008 Geser F, Winton MJ, Kwong LK, Xu Y, Xie SX, Igaz LM, Garruto RM, Perl DP, Galasko D, Lee VM, Trojanowski JQ. Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam. Acta Neuropathologica. 115: 133-45. PMID 17713769 DOI: 10.1007/S00401-007-0257-Y  0.347
2008 Akram A, Christoffel D, Rocher AB, Bouras C, Kövari E, Perl DP, Morrison JH, Herrmann FR, Haroutunian V, Giannakopoulos P, Hof PR. Stereologic estimates of total spinophilin-immunoreactive spine number in area 9 and the CA1 field: relationship with the progression of Alzheimer's disease. Neurobiology of Aging. 29: 1296-307. PMID 17420070 DOI: 10.1016/J.Neurobiolaging.2007.03.007  0.344
2007 Perl DP. The neuropathology of parkinsonism. Handbook of Clinical Neurology. 83: 205-15. PMID 18808915 DOI: 10.1016/S0072-9752(07)83008-9  0.367
2007 Perl DP, Olanow CW. The neuropathology of manganese-induced Parkinsonism. Journal of Neuropathology and Experimental Neurology. 66: 675-82. PMID 17882011 DOI: 10.1097/Nen.0B013E31812503Cf  0.312
2007 Yang W, Woltjer RL, Sokal I, Pan C, Wang Y, Brodey M, Peskind ER, Leverenz JB, Zhang J, Perl DP, Galasko DR, Montine TJ. Quantitative proteomics identifies surfactant-resistant alpha-synuclein in cerebral cortex of Parkinsonism-dementia complex of Guam but not Alzheimer's disease or progressive supranuclear palsy. The American Journal of Pathology. 171: 993-1002. PMID 17675576 DOI: 10.2353/Ajpath.2007.070015  0.425
2006 Perl DP, Moalem S. Aluminum and Alzheimer's disease, a personal perspective after 25 years. Journal of Alzheimer's Disease : Jad. 9: 291-300. PMID 17004365 DOI: 10.3233/Jad-2006-9S332  0.454
2006 Perl DP. Exposure to aluminium and the subsequent development of a disorder with features of Alzheimer's disease. Journal of Neurology, Neurosurgery, and Psychiatry. 77: 811. PMID 16627536 DOI: 10.1136/Jnnp.2006.090613  0.362
2006 Winton MJ, Joyce S, Zhukareva V, Practico D, Perl DP, Galasko D, Craig U, Trojanowski JQ, Lee VM. Characterization of tau pathologies in gray and white matter of Guam parkinsonism-dementia complex. Acta Neuropathologica. 111: 401-12. PMID 16609851 DOI: 10.1007/S00401-006-0053-0  0.418
2006 Rapp MA, Schnaider-Beeri M, Grossman HT, Sano M, Perl DP, Purohit DP, Gorman JM, Haroutunian V. Increased hippocampal plaques and tangles in patients with Alzheimer disease with a lifetime history of major depression. Archives of General Psychiatry. 63: 161-7. PMID 16461859 DOI: 10.1001/Archpsyc.63.2.161  0.342
2006 Prohovnik I, Perl DP, Davis KL, Libow L, Lesser G, Haroutunian V. Dissociation of neuropathology from severity of dementia in late-onset Alzheimer disease. Neurology. 66: 49-55. PMID 16401845 DOI: 10.1212/01.Wnl.0000191298.68045.50  0.419
2006 Perl DP, Moalem S. Aluminum, Alzheimer's Disease and the Geospatial Occurrence of Similar Disorders Reviews in Mineralogy and Geochemistry. 64: 115-134. DOI: 10.2138/Rmg.2006.64.4  0.367
2005 Beeri MS, Silverman JM, Davis KL, Marin D, Grossman HZ, Schmeidler J, Purohit DP, Perl DP, Davidson M, Mohs RC, Haroutunian V. Type 2 diabetes is negatively associated with Alzheimer's disease neuropathology. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 60: 471-5. PMID 15933386 DOI: 10.1093/Gerona/60.4.471  0.319
2004 Good PF, Alapat D, Hsu A, Chu C, Perl D, Wen X, Burstein DE, Kohtz DS. A role for semaphorin 3A signaling in the degeneration of hippocampal neurons during Alzheimer's disease. Journal of Neurochemistry. 91: 716-36. PMID 15485501 DOI: 10.1111/J.1471-4159.2004.02766.X  0.368
2004 McNaught KS, Kapustin A, Jackson T, Jengelley TA, Jnobaptiste R, Shashidharan P, Perl DP, Pasik P, Olanow CW. Brainstem pathology in DYT1 primary torsion dystonia. Annals of Neurology. 56: 540-7. PMID 15455404 DOI: 10.1002/Ana.20225  0.325
2004 Olanow CW, Perl DP, DeMartino GN, McNaught KS. Lewy-body formation is an aggresome-related process: a hypothesis. The Lancet. Neurology. 3: 496-503. PMID 15261611 DOI: 10.1016/S1474-4422(04)00827-0  0.343
2004 McNaught KS, Perl DP, Brownell AL, Olanow CW. Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease. Annals of Neurology. 56: 149-62. PMID 15236415 DOI: 10.1002/Ana.20186  0.32
2004 Sebeo J, Hof PR, Perl DP. Occurrence of alpha-synuclein pathology in the cerebellum of Guamanian patients with parkinsonism-dementia complex. Acta Neuropathologica. 107: 497-503. PMID 15024581 DOI: 10.1007/S00401-004-0840-4  0.351
2003 Bussière T, Giannakopoulos P, Bouras C, Perl DP, Morrison JH, Hof PR. Progressive degeneration of nonphosphorylated neurofilament protein-enriched pyramidal neurons predicts cognitive impairment in Alzheimer's disease: stereologic analysis of prefrontal cortex area 9. The Journal of Comparative Neurology. 463: 281-302. PMID 12820162 DOI: 10.1002/Cne.10760  0.399
2003 Giannakopoulos P, Herrmann FR, Bussière T, Bouras C, Kövari E, Perl DP, Morrison JH, Gold G, Hof PR. Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease. Neurology. 60: 1495-500. PMID 12743238 DOI: 10.1212/01.Wnl.0000063311.58879.01  0.386
2003 Perl DP, Hof PR, Purohit DP, Loerzel AJ, Kakulas BA. Hippocampal and entorhinal cortex neurofibrillary tangle formation in Guamanian Chamorros free of overt neurologic dysfunction. Journal of Neuropathology and Experimental Neurology. 62: 381-8. PMID 12722830 DOI: 10.1093/Jnen/62.4.381  0.336
2003 Bussière T, Gold G, Kövari E, Giannakopoulos P, Bouras C, Perl DP, Morrison JH, Hof PR. Stereologic analysis of neurofibrillary tangle formation in prefrontal cortex area 9 in aging and Alzheimer's disease. Neuroscience. 117: 577-92. PMID 12617964 DOI: 10.1016/S0306-4522(02)00942-9  0.412
2003 Hof PR, Bussière T, Gold G, Kövari E, Giannakopoulos P, Bouras C, Perl DP, Morrison JH. Stereologic evidence for persistence of viable neurons in layer II of the entorhinal cortex and the CA1 field in Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 62: 55-67. PMID 12528818 DOI: 10.1093/Jnen/62.1.55  0.375
2002 McNaught KS, Shashidharan P, Perl DP, Jenner P, Olanow CW. Aggresome-related biogenesis of Lewy bodies. The European Journal of Neuroscience. 16: 2136-48. PMID 12473081 DOI: 10.1046/J.1460-9568.2002.02301.X  0.333
2002 Hof PR, Perl DP. Neurofibrillary tangles in the primary motor cortex in Guamanian amyotrophic lateral sclerosis/parkinsonism-dementia complex. Neuroscience Letters. 328: 294-8. PMID 12147329 DOI: 10.1016/S0304-3940(02)00523-2  0.412
2002 Walker RH, Purohit DP, Good PF, Perl DP, Brin MF. Severe generalized dystonia due to primary putaminal degeneration: case report and review of the literature. Movement Disorders : Official Journal of the Movement Disorder Society. 17: 576-84. PMID 12112210 DOI: 10.1002/Mds.10098  0.351
2002 Bussière T, Friend PD, Sadeghi N, Wicinski B, Lin GI, Bouras C, Giannakopoulos P, Robakis NK, Morrison JH, Perl DP, Hof PR. Stereologic assessment of the total cortical volume occupied by amyloid deposits and its relationship with cognitive status in aging and Alzheimer's disease. Neuroscience. 112: 75-91. PMID 12044473 DOI: 10.1016/S0306-4522(02)00056-8  0.408
2002 Forman MS, Schmidt ML, Kasturi S, Perl DP, Lee VM, Trojanowski JQ. Tau and alpha-synuclein pathology in amygdala of Parkinsonism-dementia complex patients of Guam. The American Journal of Pathology. 160: 1725-31. PMID 12000724 DOI: 10.1016/S0002-9440(10)61119-4  0.376
2002 Evers MM, Purohit D, Perl D, Khan K, Marin DB. Palliative and aggressive end-of-life care for patients with dementia. Psychiatric Services. 53: 609-613. PMID 11986512 DOI: 10.1176/Appi.Ps.53.5.609  0.308
2001 Masliah E, Alford M, Galasko D, Salmon D, Hansen LA, Good PF, Perl DP, Thal L. Cholinergic deficits in the brains of patients with parkinsonism-dementia complex of Guam. Neuroreport. 12: 3901-3. PMID 11742207 DOI: 10.1097/00001756-200112210-00009  0.412
2001 Poorkaj P, Tsuang D, Wijsman E, Steinbart E, Garruto RM, Craig UK, Chapman NH, Anderson L, Bird TD, Plato CC, Perl DP, Weiderholt W, Galasko D, Schellenberg GD. TAU as a susceptibility gene for amyotropic lateral sclerosis-parkinsonism dementia complex of Guam. Archives of Neurology. 58: 1871-8. PMID 11708997 DOI: 10.1001/Archneur.58.11.1871  0.309
2001 Schmidt ML, Zhukareva V, Perl DP, Sheridan SK, Schuck T, Lee VM, Trojanowski JQ. Spinal cord neurofibrillary pathology in Alzheimer disease and Guam Parkinsonism-dementia complex. Journal of Neuropathology and Experimental Neurology. 60: 1075-86. PMID 11706937 DOI: 10.1093/Jnen/60.11.1075  0.37
2001 Perl DP. Barney Sachs and the history of the neuropathologic description of Tay-Sachs disease. Advances in Genetics. 44: 11-23. PMID 11596977 DOI: 10.1016/S0065-2660(01)44066-1  0.382
2000 Perl DP, Good PF, Bussière T, Morrison JH, Erwin JM, Hof PR. Practical approaches to stereology in the setting of aging- and disease-related brain banks. Journal of Chemical Neuroanatomy. 20: 7-19. PMID 11074340 DOI: 10.1016/S0891-0618(00)00077-6  0.336
2000 Perl DP. Neuropathology of Alzheimer's disease and related disorders. Neurologic Clinics. 18: 847-64. PMID 11072264 DOI: 10.1016/S0733-8619(05)70229-2  0.429
2000 Shashidharan P, Good PF, Hsu A, Perl DP, Brin MF, Olanow CW. TorsinA accumulation in Lewy bodies in sporadic Parkinson's disease. Brain Research. 877: 379-81. PMID 10986355 DOI: 10.1016/S0006-8993(00)02702-5  0.334
2000 Haroutunian V, Serby M, Purohit DP, Perl DP, Marin D, Lantz M, Mohs RC, Davis KL. Contribution of Lewy body inclusions to dementia in patients with and without Alzheimer disease neuropathological conditions. Archives of Neurology. 57: 1145-50. PMID 10927794 DOI: 10.1001/Archneur.57.8.1145  0.438
2000 Oyanagi K, Chen KM, Craig UK, Yamazaki M, Perl DP. Parkinsonism, dementia and vertical gaze palsy in a Guamanian with atypical neuroglial degeneration. Acta Neuropathologica. 99: 73-80. PMID 10651031 DOI: 10.1007/Pl00007410  0.392
2000 Bussiere T, Wicinski BA, Lin GI, Perl DP, Davies P, Nixon RA, Morrison JH, Hof PR. Stereologic analysis of vulnerable neocortical neurons in normal aging and Alzheimer's disease Neurobiology of Aging. 21: 24-25. DOI: 10.1016/S0197-4580(00)82787-6  0.398
1999 Davis KL, Mohs RC, Marin DB, Purohit DP, Perl DP, Lantz M, Austin G, Haroutunian V. Neuropeptide abnormalities in patients with early Alzheimer disease. Archives of General Psychiatry. 56: 981-7. PMID 10565496 DOI: 10.1001/Archpsyc.56.11.981  0.405
1999 Haroutunian V, Purohit DP, Perl DP, Marin D, Khan K, Lantz M, Davis KL, Mohs RC. Neurofibrillary tangles in nondemented elderly subjects and mild Alzheimer disease. Archives of Neurology. 56: 713-8. PMID 10369312 DOI: 10.1001/Archneur.56.6.713  0.411
1999 Nimchinsky EA, Gilissen E, Allman JM, Perl DP, Erwin JM, Hof PR. A neuronal morphologic type unique to humans and great apes. Proceedings of the National Academy of Sciences of the United States of America. 96: 5268-73. PMID 10220455 DOI: 10.1073/Pnas.96.9.5268  0.361
1999 Davis KL, Mohs RC, Marin D, Purohit DP, Perl DP, Lantz M, Austin G, Haroutunian V. Cholinergic markers in elderly patients with early signs of Alzheimer disease. Jama. 281: 1401-6. PMID 10217056 DOI: 10.1001/Jama.281.15.1401  0.406
1999 Bussière T, Hof PR, Mailliot C, Brown CD, Caillet-Boudin ML, Perl DP, Buée L, Delacourte A. Phosphorylated serine422 on tau proteins is a pathological epitope found in several diseases with neurofibrillary degeneration. Acta Neuropathologica. 97: 221-30. PMID 10090668 DOI: 10.1007/S004010050978  0.404
1999 Hof PR, Good PF, Bouras C, Morrison JH, Perl DP. STEREOLOGICALLY VALID QUANTITATIVE INDICES OF NEURODEGENERATION IN ALZHEIMERʼS DISEASE AND NORMAL AGING Journal of Neuropathology and Experimental Neurology. 58: 533. DOI: 10.1097/00005072-199905000-00108  0.33
1999 Perl DP, Purohit DP, Kakulas BA, Hof PR. CHANGES IN THE NEUROPATHOLOGIC FEATURES OF PARKINSONISM-DEMENTIA COMPLEX OF GUAM (PDC), CASES FROM THE 1960ʼS COMPARED TO CURRENT CASES Journal of Neuropathology and Experimental Neurology. 58: 515. DOI: 10.1097/00005072-199905000-00035  0.31
1998 Perl DP, Olanow CW, Calne D. Alzheimer's disease and Parkinson's disease: distinct entities or extremes of a spectrum of neurodegeneration? Annals of Neurology. 44: S19-31. PMID 9749570 DOI: 10.1002/Ana.410440705  0.417
1998 Haroutunian V, Perl DP, Purohit DP, Marin D, Khan K, Lantz M, Davis KL, Mohs RC. Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease. Archives of Neurology. 55: 1185-91. PMID 9740112 DOI: 10.1001/Archneur.55.9.1185  0.393
1998 Purohit DP, Perl DP, Haroutunian V, Powchik P, Davidson M, Davis KL. Alzheimer disease and related neurodegenerative diseases in elderly patients with schizophrenia: a postmortem neuropathologic study of 100 cases. Archives of General Psychiatry. 55: 205-11. PMID 9510214 DOI: 10.1001/Archpsyc.55.3.205  0.381
1998 Schmidt ML, Lee VM, Saido T, Perl D, Schuck T, Iwatsubo T, Trojanowski JQ. Amyloid plaques in Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex contain species of A beta similar to those found in the amyloid plaques of Alzheimer's disease and pathological aging. Acta Neuropathologica. 95: 117-22. PMID 9498044 DOI: 10.1007/S004010050774  0.395
1998 Schmidt ML, -Y. Lee VM, Saido T, Perl D, Schuck T, Iwatsubo T, Troianowski JO. AMYLOID PLAQUES IN GUAM AMYOTROPHIC LATERAL SCLEROSIS/AND PARKINSONISM-DEMENTIA COMPLEX (ALS/PDC) CONTAIN SPECIES OF Aβ SIMILAR TO THOSE FOUND IN THE AMYLOID PLAQUES OF ALZHEIMERʼS DISEASE (AD) AND PATHOLOGICAL AGING (PA) Journal of Neuropathology and Experimental Neurology. 57: 475. DOI: 10.1097/00005072-199805000-00037  0.39
1997 Perl DP, Purohit DP. Proposal to revise the morphologic criteria for the diagnosis of Alzheimer's disease. Neurobiology of Aging. 18: S81-4. PMID 9330991 DOI: 10.1016/S0197-4580(97)00076-6  0.391
1997 Buée-Scherrer V, Buée L, Leveugle B, Perl DP, Vermersch P, Hof PR, Delacourte A. Pathological tau proteins in postencephalitic parkinsonism: comparison with Alzheimer's disease and other neurodegenerative disorders. Annals of Neurology. 42: 356-9. PMID 9307257 DOI: 10.1002/Ana.410420312  0.432
1997 Bouras C, Giannakopoulos P, Good PF, Hsu A, Hof PR, Perl DP. A laser microprobe mass analysis of brain aluminum and iron in dementia pugilistica: comparison with Alzheimer's disease. European Neurology. 38: 53-8. PMID 9252800 DOI: 10.1159/000112903  0.363
1997 Li G, Aryan M, Silverman JM, Haroutunian V, Perl DP, Birstein S, Lantz M, Marin DB, Mohs RC, Davis KL. The validity of the family history method for identifying Alzheimer disease. Archives of Neurology. 54: 634-40. PMID 9152121 DOI: 10.1001/Archneur.1997.00550170104021  0.379
1996 Buée Scherrer V, Hof PR, Buée L, Leveugle B, Vermersch P, Perl DP, Olanow CW, Delacourte A. Hyperphosphorylated tau proteins differentiate corticobasal degeneration and Pick's disease. Acta Neuropathologica. 91: 351-9. PMID 8928611 DOI: 10.1007/S004010050436  0.424
1996 McKeown DA, Doty RL, Perl DP, Frye RE, Simms I, Mester A. Olfactory function in young adolescents with Down's syndrome. Journal of Neurology, Neurosurgery, and Psychiatry. 61: 412-4. PMID 8890783 DOI: 10.1136/Jnnp.61.4.412  0.342
1996 Buée L, Pérez-Tur J, Leveugle B, Buée-Scherrer V, Mufson EJ, Loerzel AJ, Chartier-Harlin MC, Perl DP, Delacourte A, Hof PR. Apolipoprotein E in Guamanian amyotrophic lateral sclerosis/parkinsonism-dementia complex: genotype analysis and relationships to neuropathological changes. Acta Neuropathologica. 91: 247-53. PMID 8834536 DOI: 10.1007/S004010050422  0.366
1996 Li G, Silverman JM, Altstiel LD, Haroutunian V, Perl DP, Purohit D, Birstein S, Lantz M, Mohs RC, Davis KL. Apolipoprotein E-epsilon 4 allele and familial risk in Alzheimer's disease. Genetic Epidemiology. 13: 285-98. PMID 8797010 DOI: 10.1002/(Sici)1098-2272(1996)13:3<285::Aid-Gepi5>3.0.Co;2-5  0.369
1996 Gabriel SM, Davidson M, Haroutunian V, Powchik P, Bierer LM, Purohit DP, Perl DP, Davis KL. Neuropeptide deficits in schizophrenia vs. Alzheimer's disease cerebral cortex. Biological Psychiatry. 39: 82-91. PMID 8717605 DOI: 10.1016/0006-3223(95)00066-6  0.344
1996 Olanow CW, Good PF, Shinotoh H, Hewitt KA, Vingerhoets F, Snow BJ, Beal MF, Calne DB, Perl DP. Manganese intoxication in the rhesus monkey: a clinical, imaging, pathologic, and biochemical study. Neurology. 46: 492-8. PMID 8614520 DOI: 10.1212/Wnl.46.2.492  0.312
1996 Mawal-Dewan M, Schmidt LM, Balin B, Perl DP, Lee VM, Trojanowski JQ. Identification of Phosphorylation Sites in PHF-TAU from Patients with Guam Amyotrophic Lateral Sclerosis/Parkinsonism-dementia Complex Journal of Neuropathology and Experimental Neurology. 55: 1051-1059. DOI: 10.1097/00005072-199655100-00005  0.379
1995 Bierer LM, Haroutunian V, Gabriel S, Knott PJ, Carlin LS, Purohit DP, Perl DP, Schmeidler J, Kanof P, Davis KL. Neurochemical correlates of dementia severity in Alzheimer's disease: relative importance of the cholinergic deficits. Journal of Neurochemistry. 64: 749-60. PMID 7830069 DOI: 10.1046/J.1471-4159.1995.64020749.X  0.395
1995 Bierer LM, Hof PR, Purohit DP, Carlin L, Schmeidler J, Davis KL, Perl DP. Neocortical neurofibrillary tangles correlate with dementia severity in Alzheimer's disease. Archives of Neurology. 52: 81-8. PMID 7826280 DOI: 10.1001/Archneur.1995.00540250089017  0.446
1995 Hof PR, Bouras C, Perl DP, Sparks DL, Mehta N, Morrison JH. Age-related distribution of neuropathologic changes in the cerebral cortex of patients with Down's syndrome. Quantitative regional analysis and comparison with Alzheimer's disease. Archives of Neurology. 52: 379-91. PMID 7710374 DOI: 10.1001/Archneur.1995.00540280065020  0.417
1995 Kordower JH, Freeman TB, Snow BJ, Vingerhoets FJ, Mufson EJ, Sanberg PR, Hauser RA, Smith DA, Nauert GM, Perl DP. Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease. The New England Journal of Medicine. 332: 1118-24. PMID 7700284 DOI: 10.1056/Nejm199504273321702  0.309
1995 Horinouchi K, Erlich S, Perl DP, Ferlinz K, Bisgaier CL, Sandhoff K, Desnick RJ, Stewart CL, Schuchman EH. Acid sphingomyelinase deficient mice: a model of types A and B Niemann-Pick disease. Nature Genetics. 10: 288-93. PMID 7670466 DOI: 10.1038/Ng0795-288  0.317
1995 Perl DP, Davidson M, Haroutunian V, Davis KL. ALZHEIMERʼS DISEASE AND RELATED NEURODEGENERATIVE DISEASES IN ELDERLY SCHIZOPHRENIC PATIENTS: A POST-MORTEM NEUROPATHOLOGIC STUDY OF 100 CASES. DP Purohit Journal of Neuropathology and Experimental Neurology. 54: 460. DOI: 10.1097/00005072-199505000-00211  0.382
1994 Hof PR, Bouras C, Perl DP, Morrison JH. Quantitative neuropathologic analysis of Pick's disease cases: cortical distribution of Pick bodies and coexistence with Alzheimer's disease. Acta Neuropathologica. 87: 115-24. PMID 8171960 DOI: 10.1007/Bf00296179  0.422
1994 Vickers JC, Morrison JH, Friedrich VL, Elder GA, Perl DP, Katz RN, Lazzarini RA. Age-associated and cell-type-specific neurofibrillary pathology in transgenic mice expressing the human midsized neurofilament subunit. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 5603-12. PMID 8083756 DOI: 10.1523/Jneurosci.14-09-05603.1994  0.317
1994 Buée L, Hof PR, Bouras C, Delacourte A, Perl DP, Morrison JH, Fillit HM. Pathological alterations of the cerebral microvasculature in Alzheimer's disease and related dementing disorders. Acta Neuropathologica. 87: 469-80. PMID 8059599 DOI: 10.1007/Bf00294173  0.468
1994 Haroutunian V, Davidson M, Kanof PD, Perl DP, Powchik P, Losonczy M, McCrystal J, Purohit DP, Bierer LM, Davis KL. Cortical cholinergic markers in schizophrenia. Schizophrenia Research. 12: 137-44. PMID 8043524 DOI: 10.1016/0920-9964(94)90071-X  0.404
1994 Leveugle B, Spik G, Perl DP, Bouras C, Fillit HM, Hof PR. The iron-binding protein lactotransferrin is present in pathologic lesions in a variety of neurodegenerative disorders: a comparative immunohistochemical analysis. Brain Research. 650: 20-31. PMID 7953673 DOI: 10.1016/0006-8993(94)90202-X  0.443
1994 Hof PR, Perl DP, Loerzel AJ, Steele JC, Morrison JH. Amyotrophic lateral sclerosis and parkinsonism-dementia from Guam: differences in neurofibrillary tangle distribution and density in the hippocampal formation and neocortex. Brain Research. 650: 107-16. PMID 7953661 DOI: 10.1016/0006-8993(94)90212-7  0.409
1994 Gabriel SM, Bierer LM, Davidson M, Purohit DP, Perl DP, Harotunian V. Galanin-like immunoreactivity is increased in the postmortem cerebral cortex from patients with Alzheimer's disease. Journal of Neurochemistry. 62: 1516-23. PMID 7510783 DOI: 10.1046/J.1471-4159.1994.62041516.X  0.418
1994 Altstiel LD, Greenberg D, Haroutunian V, Perl DP, Keddache M, Purohit DP, Yang X, Mohs R, Davis KL. Apolipoprotein E allele ϵ4 in autopsy-confirmed Alzheimer's disease and cerebrovascular disease Neurobiology of Aging. 15. DOI: 10.1016/0197-4580(94)93090-2  0.376
1993 Purohit DP, Davidson M, Perl DP, Powchik P, Haroutunian VH, Bierer LM, McCrystal J, Losonczy M, Davis KL. Severe cognitive impairment in elderly schizophrenic patients: a clinicopathological study. Biological Psychiatry. 33: 255-60. PMID 8471678 DOI: 10.1016/0006-3223(93)90291-K  0.384
1993 Good PF, Perl DP. Aluminium in Alzheimer's? Nature. 362: 418. PMID 8464473 DOI: 10.1038/362418B0  0.36
1993 Good PF, Perl DP. Laser microprobe mass analysis in Alzheimer's disease. Annals of Neurology. 34: 413-5. PMID 8363361 DOI: 10.1002/Ana.410340321  0.332
1993 Powchik P, Davidson M, Nemeroff CB, Haroutunian V, Purohit D, Losonczy M, Bissette G, Perl D, Ghanbari H, Miller B. Alzheimer's-disease-related protein in geriatric schizophrenic patients with cognitive impairment. The American Journal of Psychiatry. 150: 1726-7. PMID 8214183 DOI: 10.1176/Ajp.150.11.1726  0.397
1993 Bierer LM, Knott PJ, Schmeidler JM, Marin DB, Ryan TM, Haroutunian V, Purohit DP, Perl DP, Mohs RC, Davis KL. Post-mortem examination of dopaminergic parameters in Alzheimer's disease: relationship to noncognitive symptoms. Psychiatry Research. 49: 211-7. PMID 8177917 DOI: 10.1016/0165-1781(93)90062-L  0.382
1993 Gabriel SM, Bierer LM, Harotunian V, Purohit DP, Perl DP, Davis KL. Widespread deficits in somatostatin but not neuropeptide Y concentrations in Alzheimer's disease cerebral cortex. Neuroscience Letters. 155: 116-20. PMID 8103205 DOI: 10.1016/0304-3940(93)90686-F  0.393
1992 Good PF, Perl DP, Bierer LM, Schmeidler J. Selective accumulation of aluminum and iron in the neurofibrillary tangles of Alzheimer's disease: a laser microprobe (LAMMA) study. Annals of Neurology. 31: 286-92. PMID 1637136 DOI: 10.1002/Ana.410310310  0.418
1992 Hof PR, Bierer LM, Perl DP, Delacourte A, Buée L, Bouras C, Morrison JH. Evidence for early vulnerability of the medial and inferior aspects of the temporal lobe in an 82-year-old patient with preclinical signs of dementia. Regional and laminar distribution of neurofibrillary tangles and senile plaques. Archives of Neurology. 49: 946-53. PMID 1520086 DOI: 10.1001/Archneur.1992.00530330070019  0.448
1992 Good PF, Olanow CW, Perl DP. Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease: a LAMMA study. Brain Research. 593: 343-6. PMID 1450944 DOI: 10.1016/0006-8993(92)91334-B  0.312
1992 Hof PR, Charpiot A, Delacourte A, Buée L, Purohit D, Perl DP, Bouras C. Distribution of neurofibrillary tangles and senile plaques in the cerebral cortex in postencephalitic parkinsonism. Neuroscience Letters. 139: 10-4. PMID 1407674 DOI: 10.1016/0304-3940(92)90846-Y  0.388
1992 Hof PR, Bouras C, Buée L, Delacourte A, Perl DP, Morrison JH. Differential distribution of neurofibrillary tangles in the cerebral cortex of dementia pugilistica and Alzheimer's disease cases. Acta Neuropathologica. 85: 23-30. PMID 1285493 DOI: 10.1007/Bf00304630  0.469
1992 Bierer LM, Silverman JM, Mohs RC, Haroutunian V, Lis G, Purohit D, Breitner JCS, Perl DP, Davis KL. Morbid risk to first degree relatives of neuropathologically confirmed cases of alzheimer's disease Dementia and Geriatric Cognitive Disorders. 3: 134-139. DOI: 10.1159/000107008  0.365
1991 Doty RL, Perl DP, Steele JC, Chen KM, Pierce JD, Reyes P, Kurland LT. Odor identification deficit of the parkinsonism-dementia complex of Guam: equivalence to that of Alzheimer's and idiopathic Parkinson's disease. Neurology. 41: 77-80; discussion 80. PMID 2041598 DOI: 10.1212/Wnl.41.5_Suppl_2.77  0.359
1991 Parks KM, Sugar JE, Haroutunian V, Bierer L, Perl D, Wallace WC. Reduced in vitro phosphorylation of synapsin I (site 1) in Alzheimer's disease postmortem tissues. Brain Research. Molecular Brain Research. 9: 125-34. PMID 1850067 DOI: 10.1016/0169-328X(91)90137-M  0.342
1991 Hof PR, Perl DP, Loerzel AJ, Morrison JH. Neurofibrillary tangle distribution in the cerebral cortex of parkinsonism-dementia cases from Guam: differences with Alzheimer's disease. Brain Research. 564: 306-13. PMID 1810629 DOI: 10.1016/0006-8993(91)91467-F  0.445
1991 Perl DP, Good PF. Aluminum, Alzheimer's disease, and the olfactory system. Annals of the New York Academy of Sciences. 640: 8-13. PMID 1776763 DOI: 10.1111/J.1749-6632.1991.Tb00183.X  0.38
1991 Perez N, Sugar J, Charya S, Johnson G, Merril C, Bierer L, Perl D, Haroutunian V, Wallace W. Increased synthesis and accumulation of heat shock 70 proteins in Alzheimer's disease. Brain Research. Molecular Brain Research. 11: 249-54. PMID 1661822 DOI: 10.1016/0169-328X(91)90033-T  0.381
1990 Perl DP, Good PF. Microprobe studies of aluminum accumulation in association with human central nervous system disease. Environmental Geochemistry and Health. 12: 97-101. PMID 24202575 DOI: 10.1007/Bf01734058  0.463
1989 Perl DP. Genetics and Alzheimer's disease: notes of an environment watcher (with apologies to L. Thomas). Neurobiology of Aging. 10: 444-6; discussion 44. PMID 2812210 DOI: 10.1016/0197-4580(89)90093-6  0.312
1989 Kowall NW, Pendlebury WW, Kessler JB, Perl DP, Beal MF. Aluminum-induced neurofibrillary degeneration affects a subset of neurons in rabbit cerebral cortex, basal forebrain and upper brainstem. Neuroscience. 29: 329-37. PMID 2725861 DOI: 10.1016/0306-4522(89)90060-2  0.39
1989 Anderson JP, Refolo LM, Wallace W, Mehta P, Krishnamurthi M, Gotlib J, Bierer L, Haroutunian V, Perl D, Robakis NK. Differential brain expression of the Alzheimer's amyloid precursor protein. The Embo Journal. 8: 3627-32. PMID 2583112 DOI: 10.1002/J.1460-2075.1989.Tb08536.X  0.319
1989 Good PF, Perl DP, Haroutunian V, Bierer L. Aluminum Accumulation In The Neurofibrillary Tangles Of AlzheimerʼS Disease: Not Related To Fixative Contamination Journal of Neuropathology and Experimental Neurology. 48: 334. DOI: 10.1097/00005072-198905000-00105  0.362
1989 Bierer LM, Perl DP, Haroutunian V, Ko G, Davis KL. Alzheimer's disease cases with subcortical lewy bodies show diminished neocortical tangle formation Biological Psychiatry. 25. DOI: 10.1016/0006-3223(89)91723-X  0.404
1989 Charya S, Parks KM, Merril C, Bierer L, Perl D, Haroutunian V, Davis KL, Wallace W. Examination of proteins whose synthesis is Altered in Alzheimer's disease Biological Psychiatry. 25. DOI: 10.1016/0006-3223(89)91722-8  0.308
1989 Anderson JP, Refolo LM, Haroutunian V, Bierer L, Perl D, Robakis NK, Davis KL. Processing and regional specificity of variant forms of the Alzheimer amyloid precursor protein Biological Psychiatry. 25. DOI: 10.1016/0006-3223(89)91721-6  0.326
1987 Pendlebury WW, Munoz-Garcia D, Perl DP. Cytoskeletal pathology in neurodegenerative diseases. Advances in Experimental Medicine and Biology. 221: 427-42. PMID 3324693 DOI: 10.1007/978-1-4684-7618-7_31  0.387
1987 Eidelberg D, Sotrel A, Joachim C, Selkoe D, Forman A, Pendlebury WW, Perl DP. Adult onset Hallervorden-Spatz disease with neurofibrillary pathology. A discrete clinicopathological entity. Brain : a Journal of Neurology. 110: 993-1013. PMID 2888513 DOI: 10.1093/Brain/110.4.993  0.409
1986 Perl DP, Pendlebury WW. Aluminum neurotoxicity--potential role in the pathogenesis of neurofibrillary tangle formation. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 13: 441-5. PMID 3791060 DOI: 10.1017/S0317167100037082  0.463
1986 Munoz-Garcia D, Pendlebury WW, Kessler JB, Perl DP. An immunocytochemical comparison of cytoskeletal proteins in aluminum-induced and Alzheimer-type neurofibrillary tangles. Acta Neuropathologica. 70: 243-8. PMID 3532685 DOI: 10.1007/Bf00686078  0.37
1986 Little BW, Brown PW, Rodgers-Johnson P, Perl DP, Gajdusek DC. Familial myoclonic dementia masquerading as Creutzfeldt-Jakob disease. Annals of Neurology. 20: 231-9. PMID 3530120 DOI: 10.1002/Ana.410200209  0.4
1986 Perl DP, Pendlebury WW. Neuropathology of dementia. Neurologic Clinics. 4: 355-68. PMID 2940454 DOI: 10.1016/S0733-8619(18)30974-5  0.399
1986 Perl DP, Munoz-Garcia D, Good PF, Pendlebury WW. Calculation Of Intracellular Aluminum Concentration In Neurofibrillary Tangle (Nft) Bearing And Nft-Free Hippocampal Neurons Of Als/Parkinsonism-Dementia(Pd) Of Guam Using Laser Microprobe Mass Analysis(Lamma) Journal of Neuropathology and Experimental Neurology. 45: 379. DOI: 10.1097/00005072-198605000-00195  0.315
1986 Perl DP. The aluminum hypothesis of Alzheimer's disease: A personal view based on microprobe analysis Neurobiology of Aging. 7: 550-552. DOI: 10.1016/0197-4580(86)90113-2  0.434
1985 Perl DP. Relationship of aluminum to Alzheimer's disease. Environmental Health Perspectives. 63: 149-53. PMID 4076080 DOI: 10.1289/Ehp.8563149  0.46
1983 Pendlebury WW, Perl DP, Winn WC, McQuillen JB. Neuropathologic evaluation of 40 confirmed cases of Legionella pneumonia. Neurology. 33: 1340-4. PMID 6684231 DOI: 10.1212/Wnl.33.10.1340  0.328
1982 Perl DP, Gajdusek DC, Garruto RM, Yanagihara RT, Gibbs CJ. Intraneuronal aluminum accumulation in amyotrophic lateral sclerosis and Parkinsonism-dementia of Guam. Science (New York, N.Y.). 217: 1053-5. PMID 7112111 DOI: 10.1126/Science.7112111  0.389
1980 Perl DP, Brody AR. Alzheimer's disease: X-ray spectrometric evidence of aluminum accumulation in neurofibrillary tangle-bearing neurons. Science (New York, N.Y.). 208: 297-9. PMID 7367858 DOI: 10.1126/Science.7367858  0.407
1978 Román G, Fisher M, Perl DP, Poser CM. Neurological manifestations of hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber disease): report of 2 cases and review of the literature. Annals of Neurology. 4: 130-44. PMID 707984 DOI: 10.1002/Ana.410040207  0.301
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