| Year |
Citation |
Score |
| 2023 |
Singhal R, Kotla NK, Solanki S, Huang W, Bell HN, Elderany MO, Castillo C, Shah YM. Disruption of hypoxia inducible factor-2α in neutrophils decreases colitis-associated colon cancer. American Journal of Physiology. Gastrointestinal and Liver Physiology. PMID 37933447 DOI: 10.1152/ajpgi.00182.2023 |
0.302 |
|
| 2021 |
Singhal R, Mitta SR, Das NK, Kerk SA, Sajjakulnukit P, Solanki S, Andren A, Kumar R, Olive KP, Banerjee R, Lyssiotis CA, Shah YM. HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron. The Journal of Clinical Investigation. PMID 33914705 DOI: 10.1172/JCI143691 |
0.305 |
|
| 2020 |
Singhal R, Shah YM. Oxygen battle in the gut: hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine. The Journal of Biological Chemistry. PMID 32503843 DOI: 10.1074/Jbc.Rev120.011188 |
0.399 |
|
| 2019 |
Choi EK, Aring L, Das NK, Solanki S, Inohara N, Iwase S, Samuelson LC, Shah YM, Seo YA. Impact of dietary manganese on experimental colitis in mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 31908045 DOI: 10.1096/Fj.201902396R |
0.375 |
|
| 2019 |
Cho CS, Kowalsky AH, Namkoong S, Park SR, Wu S, Kim B, James A, Gu B, Semple IA, Tohamy MA, Solanki S, Cho US, Greenson JK, Shah YM, Kim M, et al. Concurrent activation of growth factor and nutrient arms of mTORC1 induces oxidative liver injury. Cell Discovery. 5: 60. PMID 31754457 DOI: 10.1038/S41421-019-0131-9 |
0.339 |
|
| 2019 |
Das NK, Schwartz AJ, Barthel G, Inohara N, Liu Q, Sankar A, Hill DR, Ma X, Lamberg O, Schnizlein MK, Arqués JL, Spence JR, Nunez G, Patterson AD, Sun D, ... ... Shah YM, et al. Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis. Cell Metabolism. PMID 31708445 DOI: 10.1016/J.Cmet.2019.10.005 |
0.343 |
|
| 2019 |
Devenport SN, Shah YM. Functions and Implications of Autophagy in Colon Cancer. Cells. 8. PMID 31671556 DOI: 10.3390/Cells8111349 |
0.342 |
|
| 2019 |
Shen H, Ji Y, Xiong Y, Kim H, Zhong X, Jin MG, Shah YM, Omary MB, Liu Y, Qi L, Rui L. Medullary thymic epithelial NF-kB-inducing kinase (NIK)/IKKα pathway shapes autoimmunity and liver and lung homeostasis in mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 31481626 DOI: 10.1073/Pnas.1901056116 |
0.325 |
|
| 2019 |
Triner D, Shah YM. Hypoxic Regulation of Neutrophils in Cancer. International Journal of Molecular Sciences. 20. PMID 31461847 DOI: 10.3390/Ijms20174189 |
0.367 |
|
| 2019 |
Schwartz AJ, Converso-Baran K, Michele DE, Shah YM. A genetic mouse model of severe iron-deficiency anemia reveals tissue-specific transcriptional stress responses and cardiac remodeling. The Journal of Biological Chemistry. PMID 31416832 DOI: 10.1074/Jbc.Ra119.009578 |
0.334 |
|
| 2019 |
Zou W, Shah YM. A PHD in immunosuppression: oxygen-sensing pathways regulate immunosuppressive Tregs. The Journal of Clinical Investigation. 130. PMID 31355780 DOI: 10.1172/Jci130009 |
0.346 |
|
| 2019 |
Qi D, Wei M, Jiao S, Song Y, Wang X, Xie G, Taranto J, Liu Y, Duan Y, Yu B, Li H, Shah YM, Xu Q, Du J, Gonzalez FJ, et al. Hypoxia inducible factor 1α in vascular smooth muscle cells promotes angiotensin II-induced vascular remodeling via activation of CCL7-mediated macrophage recruitment. Cell Death & Disease. 10: 544. PMID 31320613 DOI: 10.1038/S41419-019-1757-0 |
0.32 |
|
| 2019 |
Solanki S, Devenport SN, Ramakrishnan SK, Shah YM. Temporal induction of intestinal epithelial hypoxia-inducible factor (HIF)-2α is sufficient to drive colitis. American Journal of Physiology. Gastrointestinal and Liver Physiology. PMID 31241981 DOI: 10.1152/Ajpgi.00081.2019 |
0.352 |
|
| 2019 |
Konstandi M, Kypreos KE, Matsubara T, Xepapadaki E, Shah YM, Krausz K, Andriopoulou CE, Kofinas A, Gonzalez FJ. Adrenoceptor-related decrease in serum triglycerides is independent of PPARα activation. The Febs Journal. PMID 31230416 DOI: 10.1111/Febs.14966 |
0.368 |
|
| 2019 |
Hibdon ES, Razumilava N, Keeley TM, Wong G, Solanki S, Shah YM, Samuelson LC. Notch and mTOR Signaling Pathways Promote Human Gastric Cancer Cell Proliferation. Neoplasia (New York, N.Y.). 21: 702-712. PMID 31129492 DOI: 10.1016/J.Neo.2019.05.002 |
0.321 |
|
| 2019 |
Ramakrishnan SK, Zhang H, Ma X, Jung I, Schwartz AJ, Triner D, Devenport SN, Das NK, Xue X, Zeng MY, Hu Y, Mortensen RM, Greenson JK, Cascalho M, Wobus CE, ... ... Shah YM, et al. Intestinal non-canonical NFκB signaling shapes the local and systemic immune response. Nature Communications. 10: 660. PMID 30737385 DOI: 10.1038/S41467-019-08581-8 |
0.329 |
|
| 2019 |
Ma X, Das NK, Castillo C, Gourani A, Perekatt AO, Verzi MP, Shah YM. SMAD family member 3 (SMAD3) and SMAD4 repress HIF2a-dependent iron-regulatory genes. The Journal of Biological Chemistry. PMID 30659096 DOI: 10.1074/Jbc.Ra118.005549 |
0.38 |
|
| 2018 |
Suresh MV, Balijepalli S, Zhang B, Singh VV, Swamy S, Panicker S, Dolgachev VA, Subramanian C, Ramakrishnan SK, Thomas B, Rao TC, Delano MJ, Machado-Aranda D, Shah YM, Raghavendran K. Hypoxia-Inducible Factor (HIF)-1α Promotes Inflammation and Injury Following Aspiration-Induced Lung Injury in Mice. Shock (Augusta, Ga.). PMID 30601332 DOI: 10.1097/Shk.0000000000001312 |
0.359 |
|
| 2018 |
Triner D, Devenport SN, Ramakrishnan SK, Ma X, Frieler RA, Greenson JK, Inohara N, Nunez G, Colacino JA, Mortensen RM, Shah YM. Neutrophils Restrict Tumor-Associated Microbiota to Reduce Growth and Invasion of Colon Tumors in Mice. Gastroenterology. PMID 30550822 DOI: 10.1053/J.Gastro.2018.12.003 |
0.329 |
|
| 2018 |
Huang J, Kelly CP, Bakirtzi K, Villafuerte Gálvez JA, Lyras D, Mileto SJ, Larcombe S, Xu H, Yang X, Shields KS, Zhu W, Zhang Y, Goldsmith JD, Patel IJ, Hansen J, ... ... Shah YM, et al. Clostridium difficile toxins induce VEGF-A and vascular permeability to promote disease pathogenesis. Nature Microbiology. PMID 30510170 DOI: 10.1038/S41564-018-0300-X |
0.327 |
|
| 2018 |
Schwartz AJ, Das NK, Ramakrishnan SK, Jain C, Jurkovic M, Wu J, Nemeth E, Lakhal-Littleton S, Colacino JA, Shah YM. Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload. The Journal of Clinical Investigation. PMID 30352047 DOI: 10.1172/Jci122359 |
0.35 |
|
| 2018 |
Turula H, Bragazzi Cunha J, Mainou BA, Ramakrishnan SK, Wilke CA, Gonzalez-Hernandez MB, Pry A, Fava J, Bassis CM, Edelman J, Shah YM, Corthesy B, Moore BB, Wobus CE. Natural Secretory Immunoglobulins Promote Enteric Viral Infections. Journal of Virology. PMID 30232191 DOI: 10.1128/Jvi.00826-18 |
0.327 |
|
| 2018 |
Triner D, Castillo C, Hakim JB, Xue X, Greenson JK, Nuñez G, Chen GY, Colacino JA, Shah YM. Myc-Associated Zinc Finger Protein Regulates the Pro-Inflammatory Response in Colitis and Colon Cancer via STAT3 Signaling. Molecular and Cellular Biology. PMID 30181395 DOI: 10.1128/Mcb.00386-18 |
0.415 |
|
| 2018 |
Xiong Y, Torsoni AS, Wu F, Shen H, Liu Y, Zhong X, Canet MJ, Shah YM, Omary MB, Liu Y, Rui L. Hepatic NF-kB-inducing kinase (NIK) suppresses mouse liver regeneration in acute and chronic liver disease. Elife. 7. PMID 30070632 DOI: 10.7554/Elife.34152 |
0.32 |
|
| 2018 |
Rocco SA, Koneva L, Middleton LYM, Thong T, Solanki S, Karram S, Nambunmee K, Harris C, Rozek LS, Sartor MA, Shah YM, Colacino JA. Cadmium exposure inhibits branching morphogenesis and causes alterations consistent with HIF-1α inhibition in human primary breast organoids. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 29741670 DOI: 10.1093/Toxsci/Kfy112 |
0.325 |
|
| 2018 |
Schofield HK, Tandon M, Park MJ, Halbrook CJ, Ramakrishnan SK, Kim EC, Shi J, Omary MB, Shah YM, Esni F, Pasca di Magliano M. Pancreatic HIF2α Stabilization Leads to Chronic Pancreatitis and Predisposes to Mucinous Cystic Neoplasm. Cellular and Molecular Gastroenterology and Hepatology. 5: 169-185.e2. PMID 29693047 DOI: 10.1016/J.Jcmgh.2017.10.008 |
0.363 |
|
| 2018 |
Dame MK, Attili D, McClintock SD, Dedhia PH, Ouillette P, Hardt O, Chin AM, Xue X, Laliberte J, Katz EL, Newsome GM, Hill DR, Miller AJ, Tsai YH, Agorku D, ... ... Shah YM, et al. Identification, isolation, and characterization of human LGR5-positive colon adenoma cells. Development (Cambridge, England). PMID 29467240 DOI: 10.1242/Dev.153049 |
0.322 |
|
| 2018 |
Park MJ, Iyer S, Xue X, Cunha JB, Gu S, Moons D, Pipe SW, Williams JA, Simeone DM, Shah YM, Omary MB. HIF1-alpha Regulates Acinar Cell Function and Response to Injury in Mouse Pancreas. Gastroenterology. PMID 29409830 DOI: 10.1053/J.Gastro.2018.01.037 |
0.358 |
|
| 2018 |
Razumilava N, Gumucio DL, Samuelson LC, Shah YM, Nusrat A, Merchant JL. Indian Hedgehog Suppresses Intestinal Inflammation. Cellular and Molecular Gastroenterology and Hepatology. 5: 63-64. PMID 29276751 DOI: 10.1016/J.Jcmgh.2017.10.003 |
0.331 |
|
| 2018 |
Xiong Y, Torsoni AS, Wu F, Shen H, Liu Y, Zhong X, Canet MJ, Shah YM, Omary MB, Liu Y, Rui L. Author response: Hepatic NF-kB-inducing kinase (NIK) suppresses mouse liver regeneration in acute and chronic liver diseases Elife. DOI: 10.7554/Elife.34152.028 |
0.307 |
|
| 2017 |
McEnerney L, Duncan K, Bang BR, Elmasry S, Li M, Miki T, Ramakrishnan SK, Shah YM, Saito T. Dual modulation of human hepatic zonation via canonical and non-canonical Wnt pathways. Experimental & Molecular Medicine. 49: e413. PMID 29244788 DOI: 10.1038/Emm.2017.226 |
0.358 |
|
| 2017 |
Xue X, Bredell BX, Anderson ER, Martin A, Mays C, Nagao-Kitamoto H, Huang S, Győrffy B, Greenson JK, Hardiman K, Spence JR, Kamada N, Shah YM. Quantitative proteomics identifies STEAP4 as a critical regulator of mitochondrial dysfunction linking inflammation and colon cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 29078383 DOI: 10.1073/Pnas.1712946114 |
0.354 |
|
| 2017 |
Xie C, Yagai T, Luo Y, Liang X, Chen T, Wang Q, Sun D, Zhao J, Ramakrishnan SK, Sun L, Jiang C, Xue X, Tian Y, Krausz KW, Patterson AD, ... Shah YM, et al. Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis. Nature Medicine. PMID 29035368 DOI: 10.1038/Nm.4412 |
0.423 |
|
| 2017 |
Frieler RA, Chung Y, Ahlers CG, Gheordunescu G, Song J, Vigil TM, Shah YM, Mortensen RM. Genetic neutrophil deficiency ameliorates cerebral ischemia-reperfusion injury. Experimental Neurology. PMID 28865993 DOI: 10.1016/J.Expneurol.2017.08.016 |
0.305 |
|
| 2017 |
Ma X, Zhang H, Xue X, Shah YM. Hypoxia-inducible factor 2α (HIF-2α) promotes colon cancer growth by potentiating Yes-associated protein 1 (YAP1) activity. The Journal of Biological Chemistry. PMID 28848049 DOI: 10.1074/Jbc.M117.805655 |
0.418 |
|
| 2017 |
Ma X, Pham VT, Mori H, MacDougald OA, Shah YM, Bodary PF. Iron elevation and adipose tissue remodeling in the epididymal depot of a mouse model of polygenic obesity. Plos One. 12: e0179889. PMID 28651003 DOI: 10.1371/Journal.Pone.0179889 |
0.309 |
|
| 2017 |
Ro S, Xue X, Shah Y, Lee JH. Abstract LB-035: Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis Cancer Research. 77. DOI: 10.1158/1538-7445.Am2017-Lb-035 |
0.384 |
|
| 2017 |
Triner D, Shah YM. MAZ Promotes Colitis-Associated Colon Tumorigenesis Through Regulation of STAT3 Signaling Gastroenterology. 152. DOI: 10.1016/S0016-5085(17)30408-0 |
0.32 |
|
| 2016 |
Triner D, Xue X, Schwartz AJ, Jung I, Colacino JA, Shah YM. Epithelial hypoxia-inducible factor-2α facilitates the progression of colon tumors through recruiting neutrophils. Molecular and Cellular Biology. PMID 27956697 DOI: 10.1128/Mcb.00481-16 |
0.417 |
|
| 2016 |
Ji T, Takabayashi H, Mao M, Han X, Xue X, Brazil JC, Eaton KA, Shah YM, Todisco A. Regulation and function of Bone Morphogenetic Protein signaling in colonic injury and inflammation. American Journal of Physiology. Gastrointestinal and Liver Physiology. ajpgi.00169.2016. PMID 27856416 DOI: 10.1152/Ajpgi.00169.2016 |
0.39 |
|
| 2016 |
Essien BE, Sundaresan S, Ocadiz-Ruiz R, Chavis A, Tsao AC, Tessier AJ, Hayes MM, Photenhauer A, Saqui-Salces M, Kang AJ, Shah YM, Györffy B, Merchant JL. Transcription factor ZBP-89 drives a feedforward loop of β-catenin expression in colorectal cancer. Cancer Research. PMID 27758879 DOI: 10.1158/0008-5472.Can-15-3150 |
0.386 |
|
| 2016 |
Xue X, Ramakrishnan SK, Weisz K, Triner D, Xie L, Attili D, Pant A, Győrffy B, Zhan M, Carter-Su C, Hardiman KM, Wang TD, Dame MK, Varani J, Brenner D, ... ... Shah YM, et al. Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis. Cell Metabolism. PMID 27546461 DOI: 10.1016/J.Cmet.2016.07.015 |
0.389 |
|
| 2016 |
Triner D, Shah YM. Hypoxia-Inducible Factors: a central link between inflammation and cancer. The Journal of Clinical Investigation. PMID 27525434 DOI: 10.1172/Jci84430 |
0.365 |
|
| 2016 |
Casu C, Oikonomidou PR, Chen H, Nandi V, Ginzburg Y, Prasad P, Fleming RE, Shah YM, Valore EV, Nemeth E, Ganz T, MacDonald B, Rivella S. Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera. Blood. PMID 27154187 DOI: 10.1182/Blood-2015-10-676742 |
0.35 |
|
| 2016 |
Bakirtzi K, Law IK, Xue X, Iliopoulos D, Shah YM, Pothoulakis C. Neurotensin Promotes the Development of Colitis and Intestinal Angiogenesis via Hif-1α-miR-210 Signaling. Journal of Immunology (Baltimore, Md. : 1950). PMID 27076683 DOI: 10.4049/Jimmunol.1501443 |
0.344 |
|
| 2016 |
Ro SH, Xue X, Ramakrishnan SK, Cho CS, Namkoong S, Jang I, Semple IA, Ho A, Park HW, Shah YM, Lee JH. Tumor suppressive role of Sestrin2 during colitis and colon carcinogenesis. Elife. 5. PMID 26913956 DOI: 10.7554/Elife.12204 |
0.377 |
|
| 2016 |
Mori H, Yao Y, Learman BS, Kurozumi K, Ishida J, Ramakrishnan SK, Overmyer KA, Xue X, Cawthorn WP, Reid MA, Taylor M, Ning X, Shah YM, MacDougald OA. Induction of WNT11 by hypoxia and hypoxia-inducible factor-1α regulates cell proliferation, migration and invasion. Scientific Reports. 6: 21520. PMID 26861754 DOI: 10.1038/Srep21520 |
0.417 |
|
| 2016 |
Ramakrishnan SK, Zhang H, Takahashi S, Centofanti B, Periyasamy S, Weisz K, Chen Z, Uhler MD, Rui L, Gonzalez FJ, Shah YM. HIF2α Is an Essential Molecular Brake for Postprandial Hepatic Glucagon Response Independent of Insulin Signaling. Cell Metabolism. PMID 26853750 DOI: 10.1016/J.Cmet.2016.01.004 |
0.32 |
|
| 2016 |
Ramakrishnan SK, Khuder SS, Al-Share QY, Russo L, Abdallah SL, Patel PR, Heinrich G, Muturi HT, Mopidevi BR, Oyarce AM, Shah YM, Sanchez ER, Najjar SM. PPAR alpha Activation Reduces Hepatic CEACAM1 Expression to Regulate Fatty Acid Oxidation during Fasting-refeeding Transition. The Journal of Biological Chemistry. PMID 26846848 DOI: 10.1074/Jbc.M116.714014 |
0.367 |
|
| 2016 |
Shah YM. The role of hypoxia in intestinal inflammation. Molecular and Cellular Pediatrics. 3: 1-5. PMID 26812949 DOI: 10.1186/S40348-016-0030-1 |
0.406 |
|
| 2016 |
Xue X, Shah Y. Abstract 2794: Six-transmembrane epithelial antigen of prostate 4 (STEAP4): an important link between hypoxia, inflammation, nutrition and tumorigenesis in the intestine Cancer Research. 76: 2794-2794. DOI: 10.1158/1538-7445.Am2016-2794 |
0.464 |
|
| 2016 |
Park M, Iyer S, Xue X, Shah Y, Omary MB. Tu1485 Hypoxia-Inducible Factor-1a Regulates Acinar Cell Function in Mouse Pancreas Gastroenterology. 150. DOI: 10.1016/S0016-5085(16)33097-9 |
0.313 |
|
| 2016 |
Triner DA, Xue X, Shah Y. 372 Pro-Inflammatory HIF2α/MAZ Signaling Increases Colitis & Colon Cancer by Modulating the Immune Environment Gastroenterology. 150. DOI: 10.1016/S0016-5085(16)30397-3 |
0.315 |
|
| 2015 |
Ramakrishnan SK, Shah YM. Role of Intestinal HIF-2α in Health and Disease. Annual Review of Physiology. PMID 26667076 DOI: 10.1146/Annurev-Physiol-021115-105202 |
0.391 |
|
| 2015 |
Zhang H, Ramakrishnan SK, Triner D, Centofanti B, Maitra D, Győrffy B, Sebolt-Leopold JS, Dame MK, Varani J, Brenner DE, Fearon ER, Omary MB, Shah YM. Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1. Science Signaling. 8: ra98. PMID 26443705 DOI: 10.1126/Scisignal.Aac5418 |
0.367 |
|
| 2015 |
Das N, Xie L, Ramakrishnan SK, Campbell A, Rivella S, Shah YM. Intestine-specific Disruption of Hypoxia-inducible Factor (HIF)-2α Improves Anemia in Sickle Cell Disease. The Journal of Biological Chemistry. 290: 23523-7. PMID 26296885 DOI: 10.1074/Jbc.C115.681643 |
0.423 |
|
| 2015 |
Ramakrishnan SK, Anderson ER, Martin A, Centofanti B, Shah YM. Maternal intestinal HIF-2α is necessary for sensing iron demands of lactation in mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 26124130 DOI: 10.1073/Pnas.1504891112 |
0.379 |
|
| 2015 |
Hu B, Guo Y, Garbacz WG, Jiang M, Xu M, Huang H, Tsung A, Billiar TR, Ramakrishnan SK, Shah Y, Lam KS, Huang M, Xie W. Fatty acid binding protein-4 (FABP4) is a hypoxia inducible gene that sensitizes mice to liver ischemia/re-perfusion injury. Journal of Hepatology. PMID 26070408 DOI: 10.1016/J.Jhep.2015.05.030 |
0.353 |
|
| 2015 |
Essien BE, Yang A, Tessier AJ, Marquette A, Tsao AC, Photenhauer A, Shah YM, Gyorffy B, Merchant JL. 404 ZBP-89 Recruits Hdacs to β-Catenin Target Genes Regulated by Butyrate Contributing to Colorectal Cancer Progression and Heterogeneity Gastroenterology. 148. DOI: 10.1016/S0016-5085(15)30298-5 |
0.325 |
|
| 2014 |
Zhou X, Cao L, Jiang C, Xie Y, Cheng X, Krausz KW, Qi Y, Sun L, Shah YM, Gonzalez FJ, Wang G, Hao H. PPARα-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis. Nature Communications. 5: 4573. PMID 25183423 DOI: 10.1038/Ncomms5573 |
0.354 |
|
| 2014 |
Qi Y, Jiang C, Tanaka N, Krausz KW, Brocker CN, Fang ZZ, Bredell BX, Shah YM, Gonzalez FJ. PPARα-dependent exacerbation of experimental colitis by the hypolipidemic drug fenofibrate. American Journal of Physiology. Gastrointestinal and Liver Physiology. 307: G564-73. PMID 25035112 DOI: 10.1152/Ajpgi.00153.2014 |
0.401 |
|
| 2014 |
Holden VI, Lenio S, Kuick R, Ramakrishnan SK, Shah YM, Bachman MA. Bacterial siderophores that evade or overwhelm lipocalin 2 induce hypoxia inducible factor 1α and proinflammatory cytokine secretion in cultured respiratory epithelial cells. Infection and Immunity. 82: 3826-36. PMID 24980968 DOI: 10.1128/Iai.01849-14 |
0.381 |
|
| 2014 |
Xie L, Xue X, Taylor M, Ramakrishnan SK, Nagaoka K, Hao C, Gonzalez FJ, Shah YM. Hypoxia-inducible factor/MAZ-dependent induction of caveolin-1 regulates colon permeability through suppression of occludin, leading to hypoxia-induced inflammation. Molecular and Cellular Biology. 34: 3013-23. PMID 24891620 DOI: 10.1128/Mcb.00324-14 |
0.455 |
|
| 2014 |
Xue X, Ramakrishnan SK, Shah YM. Activation of HIF-1α does not increase intestinal tumorigenesis. American Journal of Physiology. Gastrointestinal and Liver Physiology. 307: G187-95. PMID 24875099 DOI: 10.1152/Ajpgi.00112.2014 |
0.413 |
|
| 2014 |
Manna SK, Tanaka N, Krausz KW, Haznadar M, Xue X, Matsubara T, Bowman ED, Fearon ER, Harris CC, Shah YM, Gonzalez FJ. Biomarkers of coordinate metabolic reprogramming in colorectal tumors in mice and humans. Gastroenterology. 146: 1313-24. PMID 24440673 DOI: 10.1053/J.Gastro.2014.01.017 |
0.337 |
|
| 2014 |
Ramakrishnan SK, Taylor M, Qu A, Ahn SH, Suresh MV, Raghavendran K, Gonzalez FJ, Shah YM. Loss of von Hippel-Lindau protein (VHL) increases systemic cholesterol levels through targeting hypoxia-inducible factor 2α and regulation of bile acid homeostasis. Molecular and Cellular Biology. 34: 1208-20. PMID 24421394 DOI: 10.1128/Mcb.01441-13 |
0.387 |
|
| 2014 |
Shah YM, Xie L. Hypoxia-inducible factors link iron homeostasis and erythropoiesis Gastroenterology. 146: 630-642. PMID 24389303 DOI: 10.1053/J.Gastro.2013.12.031 |
0.369 |
|
| 2014 |
Qu A, Jiang C, Cai Y, Kim JH, Tanaka N, Ward JM, Shah YM, Gonzalez FJ. Role of Myc in hepatocellular proliferation and hepatocarcinogenesis. Journal of Hepatology. 60: 331-8. PMID 24096051 DOI: 10.1016/J.Jhep.2013.09.024 |
0.405 |
|
| 2014 |
Shah Y. Iron Overload in the Face of Anemia Blood. 124. DOI: 10.1182/Blood.V124.21.Sci-38.Sci-38 |
0.367 |
|
| 2014 |
Casu C, Oikonomidau R, Shah Y, Nemeth E, Ganz T, MacDonald B, Rivella S. Concurrent Treatment with Minhepcidin and Deferiprone Improves Anemia and Enhances Reduction of Spleen Iron in a Mouse Model of Non-Transfusion Dependent Thalassemia Blood. 124: 748-748. DOI: 10.1182/Blood.V124.21.748.748 |
0.336 |
|
| 2013 |
Anderson ER, Taylor M, Xue X, Ramakrishnan SK, Martin A, Xie L, Bredell BX, Gardenghi S, Rivella S, Shah YM. Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia. Proceedings of the National Academy of Sciences of the United States of America. 110: E4922-30. PMID 24282296 DOI: 10.1073/Pnas.1314197110 |
0.342 |
|
| 2013 |
Konstandi M, Shah YM, Matsubara T, Gonzalez FJ. Role of PPARα and HNF4α in Stress-Mediated Alterations in Lipid Homeostasis Plos One. 8. PMID 23967086 DOI: 10.1371/Journal.Pone.0070675 |
0.314 |
|
| 2013 |
Xue X, Ramakrishnan S, Anderson E, Taylor M, Zimmermann EM, Spence JR, Huang S, Greenson JK, Shah YM. Endothelial PAS domain protein 1 activates the inflammatory response in the intestinal epithelium to promote colitis in mice. Gastroenterology. 145: 831-41. PMID 23860500 DOI: 10.1053/J.Gastro.2013.07.010 |
0.389 |
|
| 2013 |
Ito S, Satoh J, Matsubara T, Shah YM, Ahn SH, Anderson CR, Shan W, Peters JM, Gonzalez FJ. Cholestasis induces reversible accumulation of periplakin in mouse liver. Bmc Gastroenterology. 13: 116. PMID 23849208 DOI: 10.1186/1471-230X-13-116 |
0.343 |
|
| 2013 |
Xue X, Shah YM. Intestinal iron homeostasis and colon tumorigenesis. Nutrients. 5: 2333-51. PMID 23812305 DOI: 10.3390/Nu5072333 |
0.341 |
|
| 2013 |
Anderson ER, Shah YM. Iron homeostasis in the liver. Comprehensive Physiology. 3: 315-30. PMID 23720289 DOI: 10.1002/Cphy.C120016 |
0.33 |
|
| 2013 |
Xue X, Shah YM. In vitro organoid culture of primary mouse colon tumors. Journal of Visualized Experiments : Jove. e50210. PMID 23711911 DOI: 10.3791/50210 |
0.317 |
|
| 2013 |
Jiang C, Kim JH, Li F, Qu A, Gavrilova O, Shah YM, Gonzalez FJ. Hypoxia-inducible factor 1α regulates a SOCS3-STAT3-adiponectin signal transduction pathway in adipocytes. The Journal of Biological Chemistry. 288: 3844-57. PMID 23255598 DOI: 10.1074/Jbc.M112.426338 |
0.319 |
|
| 2013 |
Xue X, Shah YM. Hypoxia-inducible factor-2α is essential in activating the COX2/mPGES-1/PGE2 signaling axis in colon cancer. Carcinogenesis. 34: 163-9. PMID 23042097 DOI: 10.1093/Carcin/Bgs313 |
0.412 |
|
| 2012 |
Khozoie C, Borland MG, Zhu B, Baek S, John S, Hager GL, Shah YM, Gonzalez FJ, Peters JM. Analysis of the peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) cistrome reveals novel co-regulatory role of ATF4. Bmc Genomics. 13: 665. PMID 23176727 DOI: 10.1186/1471-2164-13-665 |
0.336 |
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| 2012 |
Matsubara T, Tanaka N, Krausz KW, Manna SK, Kang DW, Anderson ER, Luecke H, Patterson AD, Shah YM, Gonzalez FJ. Metabolomics identifies an inflammatory cascade involved in dioxin- and diet-induced steatohepatitis. Cell Metabolism. 16: 634-44. PMID 23140643 DOI: 10.1016/J.Cmet.2012.10.006 |
0.374 |
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| 2012 |
Anderson ER, Taylor M, Xue X, Martin A, Moons DS, Omary MB, Shah YM. The hypoxia-inducible factor-C/EBPα axis controls ethanol-mediated hepcidin repression. Molecular and Cellular Biology. 32: 4068-77. PMID 22869521 DOI: 10.1128/Mcb.00723-12 |
0.367 |
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| 2012 |
Cheng J, Shah YM, Gonzalez FJ. Pregnane X receptor as a target for treatment of inflammatory bowel disorders Trends in Pharmacological Sciences. 33: 323-330. PMID 22609277 DOI: 10.1016/J.Tips.2012.03.003 |
0.37 |
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| 2012 |
Parrow NL, Gardenghi S, Ramos P, Casu C, Grady RW, Anderson ER, Shah YM, Li H, Ginzburg YZ, Fleming RE, Rivella S. Decreased hepcidin expression in murine β-thalassemia is associated with suppression of Bmp/Smad signaling. Blood. 119: 3187-9. PMID 22461476 DOI: 10.1182/Blood-2012-01-405563 |
0.32 |
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| 2012 |
Xue X, Taylor M, Anderson E, Hao C, Qu A, Greenson JK, Zimmermann EM, Gonzalez FJ, Shah YM. Hypoxia-inducible factor-2α activation promotes colorectal cancer progression by dysregulating iron homeostasis. Cancer Research. 72: 2285-93. PMID 22419665 DOI: 10.1158/0008-5472.Can-11-3836 |
0.462 |
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| 2012 |
Patterson AD, Shah YM, Matsubara T, Krausz KW, Gonzalez FJ. Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity Hepatology. 56: 281-290. PMID 22318764 DOI: 10.1002/Hep.25645 |
0.389 |
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| 2012 |
Peters JM, Shah YM, Gonzalez FJ. The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention. Nature Reviews. Cancer. 12: 181-95. PMID 22318237 DOI: 10.1038/Nrc3214 |
0.341 |
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| 2012 |
Qu A, Shah YM, Manna SK, Gonzalez FJ. Disruption of endothelial peroxisome proliferator-activated receptor γ accelerates diet-induced atherogenesis in LDL receptor-null mice Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 65-73. PMID 22015658 DOI: 10.1161/Atvbaha.111.239137 |
0.365 |
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| 2011 |
Jiang C, Qu A, Matsubara T, Chanturiya T, Jou W, Gavrilova O, Shah YM, Gonzalez FJ. Disruption of hypoxia-inducible factor 1 in adipocytes improves insulin sensitivity and decreases adiposity in high-fat diet-fed mice Diabetes. 60: 2484-2495. PMID 21873554 DOI: 10.2337/Db11-0174 |
0.323 |
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| 2011 |
Qu A, Taylor M, Xue X, Matsubara T, Metzger D, Chambon P, Gonzalez FJ, Shah YM. Hypoxia-inducible transcription factor 2α promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis. Hepatology (Baltimore, Md.). 54: 472-83. PMID 21538443 DOI: 10.1002/Hep.24400 |
0.407 |
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| 2011 |
Anderson ER, Xue X, Shah YM. Intestinal hypoxia-inducible factor-2alpha (HIF-2alpha) is critical for efficient erythropoiesis. The Journal of Biological Chemistry. 286: 19533-40. PMID 21498508 DOI: 10.1074/Jbc.M111.238667 |
0.421 |
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| 2011 |
Weerasinghe SV, Moons DS, Altshuler PJ, Shah YM, Omary MB. Fibrinogen-γ proteolysis and solubility dynamics during apoptotic mouse liver injury: heparin prevents and treats liver damage. Hepatology (Baltimore, Md.). 53: 1323-32. PMID 21480334 DOI: 10.1016/S0016-5085(11)63941-3 |
0.322 |
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| 2011 |
Taylor M, Qu A, Anderson ER, Matsubara T, Martin A, Gonzalez FJ, Shah YM. Hypoxia-inducible factor-2α mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice. Gastroenterology. 140: 2044-55. PMID 21419768 DOI: 10.1053/J.Gastro.2011.03.007 |
0.343 |
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| 2011 |
Parrow N, Gardenghi S, Ramos P, Shah Y, Fleming R, Casu C, Grady RW, Rivella S. The Regulation of Hepcidin in β-Thalassemia Blood. 118: 901-901. DOI: 10.1182/Blood.V118.21.901.901 |
0.42 |
|
| 2011 |
Taylor M, Shah Y. The Role of Hypoxia-Inducible Factor-2α in Intestinal Epithelial Barrier Function Gastroenterology. 140. DOI: 10.1016/S0016-5085(11)62907-7 |
0.366 |
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| 2011 |
Anderson ER, Taylor M, Shah Y. The Role of Hypoxia-Inducible Factor-2α in Intestinal Iron Absorption Gastroenterology. 140. DOI: 10.1016/S0016-5085(11)62906-5 |
0.383 |
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| 2010 |
Qu A, Shah YM, Matsubara T, Yang Q, Gonzalez FJ. PPARα-dependent activation of cell cycle control and DNA repair genes in hepatic nonparenchymal cells Toxicological Sciences. 118: 404-410. PMID 20813756 DOI: 10.1093/Toxsci/Kfq259 |
0.386 |
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| 2010 |
Cheng J, Shah YM, Ma X, Pang X, Tanaka T, Kodama T, Krausz KW, Gonzalez FJ. Therapeutic role of rifaximin in inflammatory bowel disease: Clinical implication of human pregnane X receptor activation Journal of Pharmacology and Experimental Therapeutics. 335: 32-41. PMID 20627999 DOI: 10.1124/Jpet.110.170225 |
0.395 |
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| 2010 |
Cheng K, Ho K, Stokes R, Scott C, Lau SM, Hawthorne WJ, O'Connell PJ, Loudovaris T, Kay TW, Kulkarni RN, Okada T, Wang XL, Yim SH, Shah Y, Grey ST, et al. Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets. The Journal of Clinical Investigation. 120: 2171-83. PMID 20440072 DOI: 10.1172/Jci35846 |
0.385 |
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| 2010 |
Wang T, Shah YM, Matsubara T, Zhen Y, Tanabe T, Nagano T, Fotso S, Krausz KW, Zabriskie TM, Idle JR, Gonzalez FJ. Control of steroid 21-oic acid synthesis by peroxisome proliferator-activated receptor alpha and role of the hypothalamic-pituitary-adrenal axis. The Journal of Biological Chemistry. 285: 7670-85. PMID 20032461 DOI: 10.1074/Jbc.M109.090175 |
0.344 |
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| 2009 |
Rageul J, Mottier S, Jarry A, Shah Y, Théoleyre S, Masson D, Gonzalez FJ, Laboisse CL, Denis MG. KLF4-dependent, PPARgamma-induced expression of GPA33 in colon cancer cell lines. International Journal of Cancer. 125: 2802-9. PMID 19551868 DOI: 10.1002/Ijc.24683 |
0.365 |
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| 2009 |
Chen C, Krausz KW, Shah YM, Idle JR, Gonzalez FJ. Serum metabolomics reveals irreversible inhibition of fatty acid β-oxidation through the suppression of PPARα activation as a contributing mechanism of acetaminophen-induced hepatotoxicity Chemical Research in Toxicology. 22: 699-707. PMID 19256530 DOI: 10.1021/Tx800464Q |
0.362 |
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| 2009 |
Shah YM, Matsubara T, Ito S, Yim SH, Gonzalez FJ. Intestinal Hypoxia-Inducible Transcription Factors Are Essential for Iron Absorption following Iron Deficiency Cell Metabolism. 9: 152-164. PMID 19147412 DOI: 10.1016/J.Cmet.2008.12.012 |
0.359 |
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| 2008 |
Ma X, Cheung C, Krausz KW, Shah YM, Wang T, Idle JR, Gonzalez FJ. A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 2506-12. PMID 18799805 DOI: 10.1124/Dmd.108.022723 |
0.369 |
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| 2008 |
Shah YM, Ito S, Morimura K, Chen C, Yim SH, Haase VH, Gonzalez FJ. Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade. Gastroenterology. 134: 2036-48, 2048.e1-3. PMID 18439915 DOI: 10.1053/J.Gastro.2008.03.009 |
0.381 |
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| 2008 |
Ahn SH, Shah YM, Inoue J, Morimura K, Kim I, Yim S, Lambert G, Kurotani R, Nagashima K, Gonzalez FJ, Inoue Y. Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel disease. Inflammatory Bowel Diseases. 14: 908-20. PMID 18338782 DOI: 10.1002/Ibd.20413 |
0.36 |
|
| 2008 |
Chen C, Shah YM, Morimura K, Krausz KW, Miyazaki M, Richardson TA, Morgan ET, Ntambi JM, Idle JR, Gonzalez FJ. Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis. Cell Metabolism. 7: 135-47. PMID 18249173 DOI: 10.1016/J.Cmet.2007.12.003 |
0.408 |
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| 2008 |
Gonzalez FJ, Shah YM. PPARα: Mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators Toxicology. 246: 2-8. PMID 18006136 DOI: 10.1016/J.Tox.2007.09.030 |
0.398 |
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| 2008 |
Yang Q, Nagano T, Shah Y, Cheung C, Ito S, Gonzalez FJ. The PPAR alpha-humanized mouse: a model to investigate species differences in liver toxicity mediated by PPAR alpha. Toxicological Sciences : An Official Journal of the Society of Toxicology. 101: 132-9. PMID 17690133 DOI: 10.1093/Toxsci/Kfm206 |
0.341 |
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| 2007 |
Dongol B, Shah Y, Kim I, Gonzalez FJ, Hunt MC. The acyl-CoA thioesterase I is regulated by PPARalpha and HNF4alpha via a distal response element in the promoter. Journal of Lipid Research. 48: 1781-91. PMID 17485727 DOI: 10.1194/Jlr.M700119-Jlr200 |
0.353 |
|
| 2007 |
Ma X, Shah YM, Guo GL, Wang T, Krausz KW, Idle JR, Gonzalez FJ. Rifaximin is a gut-specific human pregnane X receptor activator. The Journal of Pharmacology and Experimental Therapeutics. 322: 391-8. PMID 17442842 DOI: 10.1124/Jpet.107.121913 |
0.374 |
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| 2007 |
Shah YM, Morimura K, Yang Q, Tanabe T, Takagi M, Gonzalez FJ. Peroxisome proliferator-activated receptor α regulates a microRNA-mediated signaling cascade responsible for hepatocellular proliferation Molecular and Cellular Biology. 27: 4238-4247. PMID 17438130 DOI: 10.1128/Mcb.00317-07 |
0.34 |
|
| 2007 |
Kim I, Morimura K, Shah Y, Yang Q, Ward JM, Gonzalez FJ. Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice. Carcinogenesis. 28: 940-6. PMID 17183066 DOI: 10.1093/Carcin/Bgl249 |
0.377 |
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| 2007 |
Shah YM, Ma X, Morimura K, Kim I, Gonzalez FJ. Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-kappaB target gene expression. American Journal of Physiology. Gastrointestinal and Liver Physiology. 292: G1114-22. PMID 17170021 DOI: 10.1152/Ajpgi.00528.2006 |
0.412 |
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| 2007 |
Shah YM, Morimura K, Gonzalez FJ. Expression of peroxisome proliferator-activated receptor-γ in macrophage suppresses experimentally induced colitis American Journal of Physiology - Gastrointestinal and Liver Physiology. 292. PMID 17095756 DOI: 10.1152/Ajpgi.00381.2006 |
0.423 |
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| 2007 |
Ma X, Shah Y, Cheung C, Guo GL, Feigenbaum L, Krausz KW, Idle JR, Gonzalez FJ. The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 194-200. PMID 17093002 DOI: 10.1124/Dmd.106.012831 |
0.321 |
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| 2006 |
Yim SH, Shah Y, Tomita S, Morris HD, Gavrilova O, Lambert G, Ward JM, Gonzalez FJ. Disruption of the Arnt gene in endothelial cells causes hepatic vascular defects and partial embryonic lethality in mice Hepatology. 44: 550-560. PMID 16941684 DOI: 10.1002/Hep.21284 |
0.395 |
|
| 2006 |
Adachi M, Kurotani R, Morimura K, Shah Y, Sanford M, Madison BB, Gumucio DL, Marin HE, Peters JM, Young HA, Gonzalez FJ. Peroxisome proliferator activated receptor γ in colonic epithelial cells protects against experimental inflammatory bowel disease Gut. 55: 1104-1113. PMID 16547072 DOI: 10.1136/Gut.2005.081745 |
0.38 |
|
| 2005 |
Shah YM, Kaul A, Dong Y, Ip C, Rowan BG. Attenuation of estrogen receptor α (ERα) signaling by selenium in breast cancer cells via downregulation of ERα gene expression Breast Cancer Research and Treatment. 92: 239-250. PMID 16155795 DOI: 10.1007/S10549-005-3203-5 |
0.329 |
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| 2005 |
Shah YM, Rowan BG. The Src kinase pathway promotes tamoxifen agonist action in Ishikawa endometrial cells through phosphorylation-dependent stabilization of estrogen receptor α promoter interaction and elevated steroid receptor coactivator 1 activity Molecular Endocrinology. 19: 732-748. PMID 15528270 DOI: 10.1210/Me.2004-0298 |
0.309 |
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