Mark L. Kahn - Publications

Cell and Molecular Biology University of Pennsylvania, Philadelphia, PA, United States 
Medicine and Surgery, Cell Biology, Pathology, Oncology

104 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Ren AA, Snellings DA, Su YS, Hong CC, Castro M, Tang AT, Detter MR, Hobson N, Girard R, Romanos S, Lightle R, Moore T, Shenkar R, Benavides C, Beaman MM, ... ... Kahn ML, et al. PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism. Nature. PMID 33910229 DOI: 10.1038/s41586-021-03562-8  0.44
2020 Hong CC, Tang AT, Detter MR, Choi JP, Wang R, Yang X, Guerrero AA, Wittig CF, Hobson N, Girard R, Lightle R, Moore T, Shenkar R, Polster SP, Goddard LM, ... ... Kahn ML, et al. Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican. The Journal of Experimental Medicine. 217. PMID 32648916 DOI: 10.1084/Jem.20200140  0.4
2020 Polster SP, Sharma A, Tanes C, Tang AT, Mericko P, Cao Y, Carrión-Penagos J, Girard R, Koskimäki J, Zhang D, Stadnik A, Romanos SG, Lyne SB, Shenkar R, Yan K, ... ... Kahn ML, et al. Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma. Nature Communications. 11: 2659. PMID 32461638 DOI: 10.1038/S41467-020-16436-W  0.44
2019 Tang AT, Sullivan KR, Hong CC, Goddard LM, Mahadevan A, Ren A, Pardo H, Peiper A, Griffin E, Tanes C, Mattei LM, Yang J, Li L, Mericko-Ishizuka P, Shen L, ... ... Kahn ML, et al. Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation. Science Translational Medicine. 11. PMID 31776290 DOI: 10.1126/Scitranslmed.Aaw3521  0.4
2019 Welsh JD, Hoofnagle MH, Bamezai S, Oxendine M, Lim L, Hall JD, Yang J, Schultz S, Engel JD, Kume T, Oliver G, Jimenez JM, Kahn ML. Hemodynamic regulation of perivalvular endothelial gene expression prevents deep venous thrombosis. The Journal of Clinical Investigation. PMID 31710307 DOI: 10.1172/Jci124791  0.32
2019 Lim L, Bui H, Farrelly O, Yang J, Li L, Enis D, Ma W, Chen M, Oliver G, Welsh J, Kahn ML. Hemostasis stimulates lymphangiogenesis through release and activation of VEGFC. Blood. PMID 31562136 DOI: 10.1182/Blood.2019001736  0.32
2019 Koskimäki J, Zhang D, Li Y, Saadat L, Moore T, Lightle R, Polster SP, Carrión-Penagos J, Lyne SB, Zeineddine HA, Shi C, Shenkar R, Romanos S, Avner K, Srinath A, ... ... Kahn ML, et al. Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations. Acta Neuropathologica Communications. 7: 132. PMID 31426861 DOI: 10.1186/S40478-019-0789-0  0.32
2019 Pawlak JB, Bálint L, Lim L, Ma W, Davis RB, Benyo Z, Soares MJ, Oliver G, Kahn ML, Jakus Z, Caron KM. Lymphatic mimicry in maternal endothelial cells promotes placental spiral artery remodeling. The Journal of Clinical Investigation. PMID 31415243 DOI: 10.1172/Jci120446  0.32
2019 Lyne SB, Girard R, Koskimäki J, Zeineddine HA, Zhang D, Cao Y, Li Y, Stadnik A, Moore T, Lightle R, Shi C, Shenkar R, Carrión-Penagos J, Polster SP, Romanos S, ... ... Kahn ML, et al. Biomarkers of cavernous angioma with symptomatic hemorrhage. Jci Insight. 4. PMID 31217347 DOI: 10.1172/Jci.Insight.128577  0.32
2019 Outtz Reed H, Wang L, Sonett J, Chen M, Yang J, Li L, Aradi P, Jakus Z, D'Armiento JM, Hancock WW, Kahn ML. Lymphatic impairment leads to pulmonary tertiary lymphoid organ formation and alveolar damage. The Journal of Clinical Investigation. 130. PMID 30946031 DOI: 10.1172/Jci125044  0.32
2019 Koskimäki J, Girard R, Li Y, Saadat L, Zeineddine HA, Lightle R, Moore T, Lyne S, Avner K, Shenkar R, Cao Y, Shi C, Polster SP, Zhang D, Carrión-Penagos J, ... ... Kahn ML, et al. Comprehensive transcriptome analysis of cerebral cavernous malformation across multiple species and genotypes. Jci Insight. 4. PMID 30728328 DOI: 10.1172/Jci.Insight.126167  0.32
2018 Nonomura K, Lukacs V, Sweet DT, Goddard LM, Kanie A, Whitwam T, Ranade SS, Fujimori T, Kahn ML, Patapoutian A. Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation. Proceedings of the National Academy of Sciences of the United States of America. 115: 12817-12822. PMID 30482854 DOI: 10.1073/Pnas.1817070115  0.4
2018 Sweet DT, Hall JD, Welsh J, Kahn ML, Jiménez JM. Investigating Effects of Fluid Shear Stress on Lymphatic Endothelial Cells. Methods in Molecular Biology (Clifton, N.J.). 1846: 213-227. PMID 30242762 DOI: 10.1007/978-1-4939-8712-2_14  0.4
2018 Zeineddine HA, Girard R, Saadat L, Shen L, Lightle R, Moore T, Cao Y, Hobson N, Shenkar R, Avner K, Chaudager K, Koskimäki J, Polster SP, Fam MD, Shi C, ... ... Kahn ML, et al. Phenotypic characterization of murine models of cerebral cavernous malformations. Laboratory Investigation; a Journal of Technical Methods and Pathology. PMID 29946133 DOI: 10.1038/S41374-018-0030-Y  0.32
2017 Goddard LM, Duchemin AL, Ramalingan H, Wu B, Chen M, Bamezai S, Yang J, Li L, Morley MP, Wang T, Scherrer-Crosbie M, Frank DB, Engleka KA, Jameson SC, Morrisey EE, ... ... Kahn ML, et al. Hemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis. Developmental Cell. PMID 29056552 DOI: 10.1016/J.Devcel.2017.09.023  0.32
2017 Tang AT, Choi JP, Kotzin JJ, Yang Y, Hong CC, Hobson N, Girard R, Zeineddine HA, Lightle R, Moore T, Cao Y, Shenkar R, Chen M, Mericko P, Yang J, ... ... Kahn ML, et al. Endothelial TLR4 and the microbiome drive cerebral cavernous malformations. Nature. PMID 28489816 DOI: 10.1038/Nature22075  0.44
2016 Welsh JD, Kahn ML, Sweet DT. Lymphovenous hemostasis and the role of platelets in regulating lymphatic flow and lymphatic vessel maturation. Blood. PMID 27385789 DOI: 10.1182/Blood-2016-04-636415  0.4
2016 Girard R, Zeineddine HA, Orsbon C, Tan H, Moore T, Hobson N, Shenkar R, Lightle R, Shi C, Fam MD, Cao Y, Shen L, Neander AI, Rorrer A, Gallione C, ... ... Kahn ML, et al. Micro-Computed Tomography in Murine Models of Cerebral Cavernous Malformations as a Paradigm for Brain Disease. Journal of Neuroscience Methods. PMID 27345427 DOI: 10.1016/J.Jneumeth.2016.06.021  0.92
2016 Cha B, Geng X, Mahamud MR, Fu J, Mukherjee A, Kim Y, Jho EH, Kim TH, Kahn ML, Xia L, Dixon JB, Chen H, Srinivasan RS. Mechanotransduction activates canonical Wnt/β-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves. Genes & Development. PMID 27313318 DOI: 10.1101/Gad.282400.116  0.92
2016 Zhou Z, Tang AT, Wong WY, Bamezai S, Goddard LM, Shenkar R, Zhou S, Yang J, Wright AC, Foley M, Arthur JS, Whitehead KJ, Awad IA, Li DY, Zheng X, ... Kahn ML, et al. Corrigendum: Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling. Nature. PMID 27281211 DOI: 10.1038/Nature18311  0.32
2016 Bui HM, Enis D, Robciuc MR, Nurmi HJ, Cohen J, Chen M, Yang Y, Dhillon V, Johnson K, Zhang H, Kirkpatrick R, Traxler E, Anisimov A, Alitalo K, Kahn ML. Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD. The Journal of Clinical Investigation. PMID 27159393 DOI: 10.1172/Jci83967  0.92
2016 Zhou Z, Tang AT, Wong WY, Bamezai S, Goddard LM, Shenkar R, Zhou S, Yang J, Wright AC, Foley M, Arthur JS, Whitehead KJ, Awad IA, Li DY, Zheng X, ... Kahn ML, et al. Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling. Nature. PMID 27027284 DOI: 10.1038/Nature17178  0.92
2015 Maltzman JS, Reed HO, Kahn ML. HA-ving lymphatics improves lung transplantation. The Journal of Clinical Investigation. 125: 3999-4001. PMID 26524589 DOI: 10.1172/Jci84549  0.92
2015 Sweet DT, Jiménez JM, Chang J, Hess PR, Mericko-Ishizuka P, Fu J, Xia L, Davies PF, Kahn ML. Lymph flow regulates collecting lymphatic vessel maturation in vivo. The Journal of Clinical Investigation. 125: 2995-3007. PMID 26214523 DOI: 10.1172/Jci79386  0.92
2015 Kahn ML. Vascular development for climate control. Developmental Cell. 33: 241-2. PMID 25942619 DOI: 10.1016/J.Devcel.2015.04.011  0.92
2015 Manne BK, Badolia R, Dangelmaier C, Eble JA, Ellmeier W, Kahn M, Kunapuli SP. Distinct pathways regulate Syk protein activation downstream of immune tyrosine activation motif (ITAM) and hemITAM receptors in platelets. The Journal of Biological Chemistry. 290: 11557-68. PMID 25767114 DOI: 10.1074/Jbc.M114.629527  0.92
2015 Yang Y, Enis D, Zheng H, Chia S, Yang J, Chen M, Dhillon V, Papayannapoulou T, Kahn ML. Cell Adhesion Mediated by VCAM-ITGα9 Interactions Enables Lymphatic Development. Arteriosclerosis, Thrombosis, and Vascular Biology. 35: 1179-89. PMID 25745057 DOI: 10.1161/Atvbaha.114.304997  0.92
2015 Zhou Z, Rawnsley DR, Goddard LM, Pan W, Cao XJ, Jakus Z, Zheng H, Yang J, Arthur JS, Whitehead KJ, Li D, Zhou B, Garcia BA, Zheng X, Kahn ML. The cerebral cavernous malformation pathway controls cardiac development via regulation of endocardial MEKK3 signaling and KLF expression. Developmental Cell. 32: 168-80. PMID 25625206 DOI: 10.1016/J.Devcel.2014.12.009  0.92
2014 Jakus Z, Gleghorn JP, Enis DR, Sen A, Chia S, Liu X, Rawnsley DR, Yang Y, Hess PR, Zou Z, Yang J, Guttentag SH, Nelson CM, Kahn ML. Lymphatic function is required prenatally for lung inflation at birth. The Journal of Experimental Medicine. 211: 815-26. PMID 24733830 DOI: 10.1084/Jem.20132308  0.92
2014 Boulaftali Y, Hess PR, Kahn ML, Bergmeier W. Platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling and vascular integrity. Circulation Research. 114: 1174-84. PMID 24677237 DOI: 10.1161/Circresaha.114.301611  0.92
2014 Zheng X, Riant F, Bergametti F, Myers CD, Tang AT, Kleaveland B, Pan W, Yang J, Tournier-Lasserve E, Kahn ML. Cerebral cavernous malformations arise independent of the heart of glass receptor. Stroke; a Journal of Cerebral Circulation. 45: 1505-9. PMID 24643410 DOI: 10.1161/Strokeaha.114.004809  0.92
2014 Hess PR, Rawnsley DR, Jakus Z, Yang Y, Sweet DT, Fu J, Herzog B, Lu M, Nieswandt B, Oliver G, Makinen T, Xia L, Kahn ML. Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life. The Journal of Clinical Investigation. 124: 273-84. PMID 24292710 DOI: 10.1172/Jci70422  0.92
2013 Liang X, Russell SR, Estelle S, Jones LH, Cho S, Kahn ML, Berndt MC, Bunting ST, Ware J, Li R. Specific inhibition of ectodomain shedding of glycoprotein Ibα by targeting its juxtamembrane shedding cleavage site. Journal of Thrombosis and Haemostasis : Jth. 11: 2155-62. PMID 24119228 DOI: 10.1111/Jth.12425  0.92
2013 Herzog BH, Fu J, Wilson SJ, Hess PR, Sen A, McDaniel JM, Pan Y, Sheng M, Yago T, Silasi-Mansat R, McGee S, May F, Nieswandt B, Morris AJ, Lupu F, ... ... Kahn ML, et al. Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature. 502: 105-9. PMID 23995678 DOI: 10.1038/Nature12501  0.92
2013 Stanger BZ, Kahn ML. Platelets and tumor cells: a new form of border control. Cancer Cell. 24: 9-11. PMID 23845439 DOI: 10.1016/J.Ccr.2013.06.009  0.92
2013 Rawnsley DR, Xiao J, Lee JS, Liu X, Mericko-Ishizuka P, Kumar V, He J, Basu A, Lu M, Lynn FC, Pack M, Gasa R, Kahn ML. The transcription factor Atonal homolog 8 regulates Gata4 and Friend of Gata-2 during vertebrate development. The Journal of Biological Chemistry. 288: 24429-40. PMID 23836893 DOI: 10.1074/Jbc.M113.463083  0.4
2013 Kahn ML, Rader DJ. Lymphatics as a new active player in reverse cholesterol transport. Cell Metabolism. 17: 627-8. PMID 23663731 DOI: 10.1016/J.Cmet.2013.04.017  0.92
2013 Zou Z, Enis DR, Bui H, Khandros E, Kumar V, Jakus Z, Thom C, Yang Y, Dhillon V, Chen M, Lu M, Weiss MJ, Kahn ML. The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis. Blood. 121: 3228-36. PMID 23426945 DOI: 10.1182/Blood-2012-10-462689  0.92
2013 Boulaftali Y, Hess PR, Getz TM, Cholka A, Stolla M, Mackman N, Owens AP, Ware J, Kahn ML, Bergmeier W. Platelet ITAM signaling is critical for vascular integrity in inflammation. The Journal of Clinical Investigation. 123: 908-16. PMID 23348738 DOI: 10.1172/Jci65154  0.92
2012 Zheng X, Xu C, Smith AO, Stratman AN, Zou Z, Kleaveland B, Yuan L, Didiku C, Sen A, Liu X, Skuli N, Zaslavsky A, Chen M, Cheng L, Davis GE, ... Kahn ML, et al. Dynamic regulation of the cerebral cavernous malformation pathway controls vascular stability and growth. Developmental Cell. 23: 342-55. PMID 22898778 DOI: 10.1016/J.Devcel.2012.06.004  0.92
2012 Acton SE, Astarita JL, Malhotra D, Lukacs-Kornek V, Franz B, Hess PR, Jakus Z, Kuligowski M, Fletcher AL, Elpek KG, Bellemare-Pelletier A, Sceats L, Reynoso ED, Gonzalez SF, Graham DB, ... ... Kahn ML, et al. Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2. Immunity. 37: 276-89. PMID 22884313 DOI: 10.1016/J.Immuni.2012.05.022  0.92
2012 Chen CY, Bertozzi C, Zou Z, Yuan L, Lee JS, Lu M, Stachelek SJ, Srinivasan S, Guo L, Vicente A, Vincente A, Mericko P, Levy RJ, Makinen T, Oliver G, ... Kahn ML, et al. Blood flow reprograms lymphatic vessels to blood vessels. The Journal of Clinical Investigation. 122: 2006-17. PMID 22622036 DOI: 10.1172/Jci57513  0.92
2012 Chen CY, Bertozzi C, Zou Z, Yuan L, Lee JS, Lu M, Stachelek SJ, Srinivasan S, Guo L, Vicente A, Mericko P, Levy RJ, Makinen T, Oliver G, Kahn ML. Blood flow reprograms lymphatic vessels to blood vessels (Journal of Clinical Investigation (2012) 122, 6 (2006-2017) DOI: 10.1172/JCI57513) Journal of Clinical Investigation. 122: 2702. DOI: 10.1172/Jci65314  0.92
2011 Schmaier AA, Stalker TJ, Runge JJ, Lee D, Nagaswami C, Mericko P, Chen M, Cliché S, Gariépy C, Brass LF, Hammer DA, Weisel JW, Rosenthal K, Kahn ML. Occlusive thrombi arise in mammals but not birds in response to arterial injury: evolutionary insight into human cardiovascular disease. Blood. 118: 3661-9. PMID 21816834 DOI: 10.1182/Blood-2011-02-338244  0.92
2011 Yuan LJ, Wang T, Kahn ML, Ferrari VA. High-resolution echocardiographic assessment of infarct size and cardiac function in mice with myocardial infarction. Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography. 24: 219-26. PMID 21194885 DOI: 10.1016/J.Echo.2010.11.001  0.92
2011 Winkelmann R, Sandrock L, Porstner M, Roth E, Mathews M, Hobeika E, Reth M, Kahn ML, Schuh W, Jäck HM. B cell homeostasis and plasma cell homing controlled by Krüppel-like factor 2. Proceedings of the National Academy of Sciences of the United States of America. 108: 710-5. PMID 21187409 DOI: 10.1073/Pnas.1012858108  0.92
2010 Bertozzi CC, Hess PR, Kahn ML. Platelets: covert regulators of lymphatic development. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 2368-71. PMID 21071706 DOI: 10.1161/Atvbaha.110.217281  0.92
2010 Zheng X, Xu C, Di Lorenzo A, Kleaveland B, Zou Z, Seiler C, Chen M, Cheng L, Xiao J, He J, Pack MA, Sessa WC, Kahn ML. CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations. The Journal of Clinical Investigation. 120: 2795-804. PMID 20592472 DOI: 10.1172/Jci39679  0.92
2010 Bertozzi CC, Schmaier AA, Mericko P, Hess PR, Zou Z, Chen M, Chen CY, Xu B, Lu MM, Zhou D, Sebzda E, Santore MT, Merianos DJ, Stadtfeld M, Flake AW, ... ... Kahn ML, et al. Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling. Blood. 116: 661-70. PMID 20363774 DOI: 10.1182/Blood-2010-02-270876  0.92
2010 Kahn ML. Jazzing up vessel growth. Blood. 115: 1479. PMID 20185593 DOI: 10.1182/Blood-2009-11-254995  0.92
2009 Schmaier AA, Zou Z, Kazlauskas A, Emert-Sedlak L, Fong KP, Neeves KB, Maloney SF, Diamond SL, Kunapuli SP, Ware J, Brass LF, Smithgall TE, Saksela K, Kahn ML. Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role. Proceedings of the National Academy of Sciences of the United States of America. 106: 21167-72. PMID 19940238 DOI: 10.1073/Pnas.0906436106  0.92
2009 Schmaier AA, Kahn ML. Platelet integrin signaling: wherefore art thou? Blood. 114: 2571-2. PMID 19779046 DOI: 10.1182/Blood-2009-08-235283  0.92
2009 Zou Z, Schmaier AA, Cheng L, Mericko P, Dickeson SK, Stricker TP, Santoro SA, Kahn ML. Negative regulation of activated alpha-2 integrins during thrombopoiesis. Blood. 113: 6428-39. PMID 19258597 DOI: 10.1182/Blood-2008-08-175356  0.92
2009 Kleaveland B, Zheng X, Liu JJ, Blum Y, Tung JJ, Zou Z, Sweeney SM, Chen M, Guo L, Lu MM, Zhou D, Kitajewski J, Affolter M, Ginsberg MH, Kahn ML. Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway. Nature Medicine. 15: 169-76. PMID 19151727 DOI: 10.1038/Nm.1918  0.92
2009 Miller MW, Basra S, Kulp DW, Billings PC, Choi S, Beavers MP, McCarty OJ, Zou Z, Kahn ML, Bennett JS, DeGrado WF. Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism. Proceedings of the National Academy of Sciences of the United States of America. 106: 719-24. PMID 19141632 DOI: 10.1073/Pnas.0811622106  0.92
2008 Neeves KB, Maloney SF, Fong KP, Schmaier AA, Kahn ML, Brass LF, Diamond SL. Microfluidic focal thrombosis model for measuring murine platelet deposition and stability: PAR4 signaling enhances shear-resistance of platelet aggregates. Journal of Thrombosis and Haemostasis : Jth. 6: 2193-201. PMID 18983510 DOI: 10.1111/J.1538-7836.2008.03188.X  0.92
2008 Kahn ML. Counteracting clotting in sepsis. Nature Medicine. 14: 918-9. PMID 18776884 DOI: 10.1038/Nm0908-918  0.92
2008 Bezman NA, Lian L, Abrams CS, Brass LF, Kahn ML, Jordan MS, Koretzky GA. Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo. The Journal of Experimental Medicine. 205: 1775-88. PMID 18663126 DOI: 10.1084/Jem.20080240  0.92
2008 Sebzda E, Zou Z, Lee JS, Wang T, Kahn ML. Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns. Nature Immunology. 9: 292-300. PMID 18246069 DOI: 10.1038/Ni1565  0.92
2008 Kahn ML. Blood is thicker than lymph. The Journal of Clinical Investigation. 118: 23-6. PMID 18097477 DOI: 10.1172/Jci34485  0.92
2008 Gardiner EE, Karunakaran D, Arthur JF, Mu FT, Powell MS, Baker RI, Hogarth PM, Kahn ML, Andrews RK, Berndt MC. Dual ITAM-mediated proteolytic pathways for irreversible inactivation of platelet receptors: de-ITAM-izing FcgammaRIIa. Blood. 111: 165-74. PMID 17848620 DOI: 10.1182/Blood-2007-04-086983  0.92
2007 Arthur JF, Shen Y, Kahn ML, Berndt MC, Andrews RK, Gardiner EE. Ligand binding rapidly induces disulfide-dependent dimerization of glycoprotein VI on the platelet plasma membrane. The Journal of Biological Chemistry. 282: 30434-41. PMID 17690106 DOI: 10.1074/Jbc.M701330200  0.92
2007 Kasirer-Friede A, Kahn ML, Shattil SJ. Platelet integrins and immunoreceptors. Immunological Reviews. 218: 247-64. PMID 17624957 DOI: 10.1111/J.1600-065X.2007.00532.X  0.92
2007 Zou Z, Chen H, Schmaier AA, Hynes RO, Kahn ML. Structure-function analysis reveals discrete beta3 integrin inside-out and outside-in signaling pathways in platelets. Blood. 109: 3284-90. PMID 17170121 DOI: 10.1182/Blood-2006-10-051664  0.92
2006 Lee JS, Yu Q, Shin JT, Sebzda E, Bertozzi C, Chen M, Mericko P, Stadtfeld M, Zhou D, Cheng L, Graf T, MacRae CA, Lepore JJ, Lo CW, Kahn ML. Klf2 is an essential regulator of vascular hemodynamic forces in vivo. Developmental Cell. 11: 845-57. PMID 17141159 DOI: 10.1016/J.Devcel.2006.09.006  0.44
2006 Kahn ML, Koretzky GA. Integrins and ITAMs: more than just good neighbors. Nature Immunology. 7: 1286-8. PMID 17110948 DOI: 10.1038/Ni1206-1286  0.92
2006 Samaha FF, Kahn ML. Novel platelet and vascular roles for immunoreceptor signaling. Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 2588-93. PMID 17023681 DOI: 10.1161/01.Atv.0000248734.89782.37  0.92
2006 Sebzda E, Hibbard C, Sweeney S, Abtahian F, Bezman N, Clemens G, Maltzman JS, Cheng L, Liu F, Turner M, Tybulewicz V, Koretzky GA, Kahn ML. Syk and Slp-76 mutant mice reveal a cell-autonomous hematopoietic cell contribution to vascular development. Developmental Cell. 11: 349-61. PMID 16950126 DOI: 10.1016/J.Devcel.2006.07.007  0.44
2006 Abtahian F, Bezman N, Clemens R, Sebzda E, Cheng L, Shattil SJ, Kahn ML, Koretzky GA. Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells. Molecular and Cellular Biology. 26: 6936-49. PMID 16943434 DOI: 10.1128/Mcb.01040-06  0.92
2006 Horii K, Kahn ML, Herr AB. Structural basis for platelet collagen responses by the immune-type receptor glycoprotein VI. Blood. 108: 936-42. PMID 16861347 DOI: 10.1182/Blood-2006-01-010215  0.92
2006 Chen H, Zou Z, Sarratt KL, Zhou D, Zhang M, Sebzda E, Hammer DA, Kahn ML. In vivo beta1 integrin function requires phosphorylation-independent regulation by cytoplasmic tyrosines. Genes & Development. 20: 927-32. PMID 16618804 DOI: 10.1101/Gad.1408306  0.92
2006 Boylan B, Berndt MC, Kahn ML, Newman PJ. Activation-independent, antibody-mediated removal of GPVI from circulating human platelets: development of a novel NOD/SCID mouse model to evaluate the in vivo effectiveness of anti-human platelet agents. Blood. 108: 908-14. PMID 16569773 DOI: 10.1182/Blood-2005-07-2937  0.92
2006 Kahn ML. GPVI: No magic bullet for thrombosis Blood. 107: 4199. DOI: 10.1182/Blood-2006-03-008342  0.92
2005 Sarratt KL, Chen H, Zutter MM, Santoro SA, Hammer DA, Kahn ML. GPVI and alpha2beta1 play independent critical roles during platelet adhesion and aggregate formation to collagen under flow. Blood. 106: 1268-77. PMID 15886326 DOI: 10.1182/Blood-2004-11-4434  0.92
2005 Samaha FF, Hibbard C, Sacks J, Chen H, Varello MA, George T, Kahn ML. Density of platelet collagen receptors glycoprotein VI and alpha2beta1 and prior myocardial infarction in human subjects, a pilot study. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research. 11: CR224-229. PMID 15874887  0.92
2005 Arthur JF, Gardiner EE, Matzaris M, Taylor SG, Wijeyewickrema L, Ozaki Y, Kahn ML, Andrews RK, Berndt MC. Glycoprotein VI is associated with GPIb-IX-V on the membrane of resting and activated platelets. Thrombosis and Haemostasis. 93: 716-23. PMID 15841318 DOI: 10.1160/Th04-09-0584  0.92
2004 Samaha FF, Hibbard C, Sacks J, Chen H, Varello MA, George T, Kahn ML. Measurement of platelet collagen receptor density in human subjects. Arteriosclerosis, Thrombosis, and Vascular Biology. 24: e181-2. PMID 15528484 DOI: 10.1161/01.Atv.0000144809.49724.71  0.92
2004 Xu B, deWaal RM, Mor-Vaknin N, Hibbard C, Markovitz DM, Kahn ML. The endothelial cell-specific antibody PAL-E identifies a secreted form of vimentin in the blood vasculature. Molecular and Cellular Biology. 24: 9198-206. PMID 15456890 DOI: 10.1128/Mcb.24.20.9198-9206.2004  0.92
2004 Kahn ML. Platelet-collagen responses: molecular basis and therapeutic promise. Seminars in Thrombosis and Hemostasis. 30: 419-25. PMID 15354263 DOI: 10.1055/S-2004-833477  0.92
2004 Gardiner EE, Arthur JF, Kahn ML, Berndt MC, Andrews RK. Regulation of platelet membrane levels of glycoprotein VI by a platelet-derived metalloproteinase. Blood. 104: 3611-7. PMID 15308568 DOI: 10.1182/Blood-2004-04-1549  0.92
2004 Sarratt KL, Chen H, Kahn ML, Hammer DA. Platelet receptor glycoprotein VI-mediated adhesion to type I collagen under hydrodynamic flow. Annals of Biomedical Engineering. 32: 970-6. PMID 15298434 DOI: 10.1023/B:Abme.0000032459.29696.65  0.92
2004 Boylan B, Chen H, Rathore V, Paddock C, Salacz M, Friedman KD, Curtis BR, Stapleton M, Newman DK, Kahn ML, Newman PJ. Anti-GPVI-associated ITP: an acquired platelet disorder caused by autoantibody-mediated clearance of the GPVI/FcRgamma-chain complex from the human platelet surface. Blood. 104: 1350-5. PMID 15150079 DOI: 10.1182/Blood-2004-03-0896  0.92
2003 Chen H, Kahn ML. Reciprocal signaling by integrin and nonintegrin receptors during collagen activation of platelets. Molecular and Cellular Biology. 23: 4764-77. PMID 12832464 DOI: 10.1128/Mcb.23.14.4764-4777.2003  0.92
2003 Locke D, Liu C, Peng X, Chen H, Kahn ML. Fc Rgamma -independent signaling by the platelet collagen receptor glycoprotein VI. The Journal of Biological Chemistry. 278: 15441-8. PMID 12594225 DOI: 10.1074/Jbc.M212338200  0.92
2003 Abtahian F, Guerriero A, Sebzda E, Lu MM, Zhou R, Mocsai A, Myers EE, Huang B, Jackson DG, Ferrari VA, Tybulewicz V, Lowell CA, Lepore JJ, Koretzky GA, Kahn ML. Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science (New York, N.Y.). 299: 247-51. PMID 12522250 DOI: 10.1126/Science.1079477  0.92
2003 Larson MK, Chen H, Kahn ML, Taylor AM, Fabre JE, Mortensen RM, Conley PB, Parise LV. Identification of P2Y12-dependent and -independent mechanisms of glycoprotein VI-mediated Rap1 activation in platelets. Blood. 101: 1409-15. PMID 12393417 DOI: 10.1182/Blood-2002-05-1533  0.92
2002 Camerer E, Kataoka H, Kahn M, Lease K, Coughlin SR. Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells. The Journal of Biological Chemistry. 277: 16081-7. PMID 11850418 DOI: 10.1074/Jbc.M108555200  0.92
2002 Locke D, Chen H, Liu Y, Liu C, Kahn ML. Lipid rafts orchestrate signaling by the platelet receptor glycoprotein VI. The Journal of Biological Chemistry. 277: 18801-9. PMID 11844795 DOI: 10.1074/Jbc.M111520200  0.92
2002 Chen H, Locke D, Liu Y, Liu C, Kahn ML. The platelet receptor GPVI mediates both adhesion and signaling responses to collagen in a receptor density-dependent fashion. The Journal of Biological Chemistry. 277: 3011-9. PMID 11723134 DOI: 10.1074/Jbc.M109714200  0.92
2002 Sarratt KL, Chen HM, Kahn ML, Hammer DA. Effect of shear stress on platelet activation via the glycoprotein VI receptor Annual International Conference of the Ieee Engineering in Medicine and Biology - Proceedings. 1: 674-675.  0.92
2001 Tulasne D, Judd BA, Johansen M, Asazuma N, Best D, Brown EJ, Kahn M, Koretzky GA, Watson SP. C-terminal peptide of thrombospondin-1 induces platelet aggregation through the Fc receptor gamma-chain-associated signaling pathway and by agglutination. Blood. 98: 3346-52. PMID 11719373 DOI: 10.1182/Blood.V98.12.3346  0.92
2001 O'Brien PJ, Molino M, Kahn M, Brass LF. Protease activated receptors: Theme and variations Oncogene. 20: 1570-1581. PMID 11313904 DOI: 10.1038/Sj.Onc.1204194  0.92
2001 Zheng YM, Liu C, Chen H, Locke D, Ryan JC, Kahn ML. Expression of the platelet receptor GPVI confers signaling via the Fc receptor gamma -chain in response to the snake venom convulxin but not to collagen. The Journal of Biological Chemistry. 276: 12999-3006. PMID 11152687 DOI: 10.1074/Jbc.M009344200  0.92
2000 Lindner JR, Kahn ML, Coughlin SR, Sambrano GR, Schauble E, Bernstein D, Foy D, Hafezi-Moghadam A, Ley K. Delayed onset of inflammation in protease-activated receptor-2-deficient mice. Journal of Immunology (Baltimore, Md. : 1950). 165: 6504-10. PMID 11086091 DOI: 10.4049/Jimmunol.165.11.6504  0.92
1999 Kahn ML, Diacovo TG, Bainton DF, Lanza F, Trejo J, Coughlin SR. Glycoprotein V-deficient platelets have undiminished thrombin responsiveness and Do not exhibit a Bernard-Soulier phenotype. Blood. 94: 4112-21. PMID 10590056 DOI: 10.1182/Blood.V94.12.4112  0.92
1999 Kahn ML, Nakanishi-Matsui M, Shapiro MJ, Ishihara H, Coughlin SR. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. The Journal of Clinical Investigation. 103: 879-87. PMID 10079109 DOI: 10.1172/Jci6042  0.92
1998 Kahn ML, Hammes SR, Botka C, Coughlin SR. Gene and locus structure and chromosomal localization of the protease-activated receptor gene family. The Journal of Biological Chemistry. 273: 23290-6. PMID 9722561 DOI: 10.1074/Jbc.273.36.23290  0.92
1998 Kahn ML, Zheng YW, Huang W, Bigornia V, Zeng D, Moff S, Farese RV, Tam C, Coughlin SR. A dual thrombin receptor system for platelet activation. Nature. 394: 690-4. PMID 9716134 DOI: 10.1038/29325  0.92
1997 Ishihara H, Connolly AJ, Zeng D, Kahn ML, Zheng YW, Timmons C, Tram T, Coughlin SR. Protease-activated receptor 3 is a second thrombin receptor in humans. Nature. 386: 502-6. PMID 9087410 DOI: 10.1038/386502A0  0.92
1996 Connolly AJ, Ishihara H, Kahn ML, Farese RV, Coughlin SR. Role of the thrombin receptor in development and evidence for a second receptor. Nature. 381: 516-9. PMID 8632823 DOI: 10.1038/381516A0  0.92
1996 Bohm SK, Kong W, Bromme D, Smeekens SP, Anderson DC, Connolly A, Kahn M, Nelken NA, Coughlin SR, Payan DG, Bunnett NW. Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. The Biochemical Journal. 314: 1009-16. PMID 8615752 DOI: 10.1042/Bj3141009  0.48
1993 Lee SW, Kahn ML, Dichek DA. Control of clot lysis by gene transfer Trends in Cardiovascular Medicine. 3: 61-66. DOI: 10.1016/1050-1738(93)90038-8  0.92
1992 Lee SW, Kahn ML, Dichek DA. Expression of an anchored urokinase in the apical endothelial cell membrane: Preservation of enzymatic activity and enhancement of cell surface plasminogen activation Journal of Biological Chemistry. 267: 13020-13027. PMID 1535628  0.92
1992 Kahn ML, Lee SW, Dichek DA. Optimization of retroviral vector-mediated gene transfer into endothelial cells in vitro Circulation Research. 71: 1508-1517. PMID 1423943 DOI: 10.1161/01.Res.71.6.1508  0.92
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