Patrick Seale - Publications

Affiliations: 
Cell and Molecular Biology University of Pennsylvania, Philadelphia, PA, United States 
Area:
Molecular Biology, Cell Biology, Human Development

67 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Angueira AR, Shapira SN, Ishibashi J, Sampat S, Sostre-Colón J, Emmett MJ, Titchenell PM, Lazar MA, Lim HW, Seale P. Early B Cell Factor Activity Controls Developmental and Adaptive Thermogenic Gene Programming in Adipocytes. Cell Reports. 30: 2869-2878.e4. PMID 32130892 DOI: 10.1016/j.celrep.2020.02.023  0.32
2019 Stine RR, Sakers AP, TeSlaa T, Kissig M, Stine ZE, Kwon CW, Cheng L, Lim HW, Kaestner KH, Rabinowitz JD, Seale P. PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism. Cell Stem Cell. PMID 31564549 DOI: 10.1016/j.stem.2019.08.017  0.32
2019 Paek J, Park SE, Lu Q, Park KT, Cho M, Oh JM, Kwon KW, Yi YS, Song JW, Edelstein HI, Ishibashi J, Yang W, Myerson JW, Kiseleva RY, Aprelev P, ... ... Seale P, et al. Microphysiological Engineering of Self-Assembled and Perfusable Microvascular Beds for the Production of Vascularized Three-Dimensional Human Microtissues. Acs Nano. PMID 31194909 DOI: 10.1021/acsnano.9b00686  0.36
2019 Wang W, Ishibashi J, Trefely S, Shao M, Cowan AJ, Sakers A, Lim HW, O'Connor S, Doan MT, Cohen P, Baur JA, King MT, Veech RL, Won KJ, Rabinowitz JD, ... ... Seale P, et al. A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate. Cell Metabolism. PMID 31155495 DOI: 10.1016/j.cmet.2019.05.005  0.56
2018 Yang W, Seale P. Stepping Up Human Beige Fat Cell Production. Cell Reports. 25: 2935-2936. PMID 30540928 DOI: 10.1016/j.celrep.2018.11.091  0.36
2018 Zhang X, Xue C, Lin J, Ferguson JF, Weiner A, Liu W, Han Y, Hinkle C, Li W, Jiang H, Gosai S, Hachet M, Garcia BA, Gregory BD, Soccio RE, ... ... Seale P, et al. Interrogation of nonconserved human adipose lincRNAs identifies a regulatory role of in adipocyte metabolism. Science Translational Medicine. 10. PMID 29925637 DOI: 10.1126/scitranslmed.aar5987  0.36
2017 Emmett MJ, Lim HW, Jager J, Richter HJ, Adlanmerini M, Peed LC, Briggs ER, Steger DJ, Ma T, Sims CA, Baur JA, Pei L, Won KJ, Seale P, Gerhart-Hines Z, et al. Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge. Nature. PMID 28614293 DOI: 10.1038/nature22819  0.32
2017 Shapira SN, Lim HW, Rajakumari S, Sakers AP, Ishibashi J, Harms MJ, Won KJ, Seale P. EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex. Genes & Development. PMID 28428261 DOI: 10.1101/gad.294405.116  0.32
2017 Kissig M, Ishibashi J, Harms MJ, Lim HW, Stine RR, Won KJ, Seale P. PRDM16 represses the type I interferon response in adipocytes to promote mitochondrial and thermogenic programing. The Embo Journal. PMID 28408438 DOI: 10.15252/embj.201695588  0.32
2017 Soccio RE, Li Z, Chen ER, Foong YH, Benson KK, Dispirito JR, Mullican SE, Emmett MJ, Briggs ER, Peed LC, Dzeng RK, Medina CJ, Jolivert JF, Kissig M, Rajapurkar SR, ... ... Seale P, et al. Targeting PPARγ in the epigenome rescues genetic metabolic defects in mice. The Journal of Clinical Investigation. PMID 28240605 DOI: 10.1172/JCI91211  0.32
2017 Plikus MV, Guerrero-Juarez CF, Ito M, Li YR, Dedhia PH, Zheng Y, Shao M, Gay DL, Ramos R, His TC, Oh JW, Wang X, Ramirez A, Konopelski SE, Elzein A, ... ... Seale P, et al. Regeneration of fat cells from myofibroblasts during wound healing. Science (New York, N.Y.). PMID 28059714 DOI: 10.1126/science.aai8792  0.56
2016 Wada S, Neinast M, Jang C, Ibrahim YH, Lee G, Babu A, Li J, Hoshino A, Rowe GC, Rhee J, Martina JA, Puertollano R, Blenis J, Morley M, Baur JA, ... Seale P, et al. The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue. Genes & Development. PMID 27913603 DOI: 10.1101/gad.287953.116  0.56
2016 Shearin AL, Monks BR, Seale P, Birnbaum MJ. Lack of AKT in adipocytes causes severe lipodystrophy. Molecular Metabolism. 5: 472-9. PMID 27408773 DOI: 10.1016/j.molmet.2016.05.006  0.68
2016 Shao M, Ishibashi J, Kusminski CM, Wang QA, Hepler C, Vishvanath L, MacPherson KA, Spurgin SB, Sun K, Holland WL, Seale P, Gupta RK. Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program. Cell Metabolism. PMID 27238639 DOI: 10.1016/j.cmet.2016.04.023  0.68
2016 Tran CM, Mukherjee S, Ye L, Frederick DW, Kissig M, Davis JG, Lamming DW, Seale P, Baur JA. Rapamycin blocks induction of the thermogenic program in white adipose tissue. Diabetes. PMID 26858361 DOI: 10.2337/db15-0502  0.68
2016 Stine RR, Shapira SN, Lim HW, Ishibashi J, Harms M, Won KJ, Seale P. EBF2 promotes the recruitment of beige adipocytes in white adipose tissue. Molecular Metabolism. 5: 57-65. PMID 26844207 DOI: 10.1016/j.molmet.2015.11.001  0.68
2015 Ishibashi J, Seale P. Functions of Prdm16 in thermogenic fat cells. Temperature (Austin, Tex.). 2: 65-72. PMID 27227007 DOI: 10.4161/23328940.2014.974444  0.32
2015 Kajimura S, Spiegelman BM, Seale P. Brown and Beige Fat: Physiological Roles beyond Heat Generation. Cell Metabolism. 22: 546-59. PMID 26445512 DOI: 10.1016/j.cmet.2015.09.007  0.68
2015 Spaethling JM, Sanchez-Alavez M, Lee J, Xia FC, Dueck H, Wang W, Fisher SA, Sul JY, Seale P, Kim J, Bartfai T, Eberwine J. Single-cell transcriptomics and functional target validation of brown adipocytes show their complex roles in metabolic homeostasis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 26304220 DOI: 10.1096/fj.15-273797  0.68
2015 Dueck H, Khaladkar M, Kim TK, Spaethling JM, Francis C, Suresh S, Fisher SA, Seale P, Beck SG, Bartfai T, Kuhn B, Eberwine J, Kim J. Deep sequencing reveals cell-type-specific patterns of single-cell transcriptome variation. Genome Biology. 16: 122. PMID 26056000 DOI: 10.1186/s13059-015-0683-4  0.68
2015 Seale P. Transcriptional Regulatory Circuits Controlling Brown Fat Development and Activation. Diabetes. 64: 2369-75. PMID 26050669 DOI: 10.2337/db15-0203  0.68
2015 DiPilato LM, Ahmad F, Harms M, Seale P, Manganiello V, Birnbaum MJ. The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin. Molecular and Cellular Biology. 35: 2752-60. PMID 26031333 DOI: 10.1128/MCB.00422-15  0.68
2015 Harms MJ, Lim HW, Ho Y, Shapira SN, Ishibashi J, Rajakumari S, Steger DJ, Lazar MA, Won KJ, Seale P. PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program. Genes & Development. 29: 298-307. PMID 25644604 DOI: 10.1101/gad.252734.114  0.68
2015 Brestoff JR, Kim BS, Saenz SA, Stine RR, Monticelli LA, Sonnenberg GF, Thome JJ, Farber DL, Lutfy K, Seale P, Artis D. Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity. Nature. 519: 242-6. PMID 25533952 DOI: 10.1038/nature14115  0.68
2015 Bartesaghi S, Hallen S, Huang L, Svensson PA, Momo RA, Wallin S, Carlsson EK, Forslöw A, Seale P, Peng XR. Thermogenic activity of UCP1 in human white fat-derived beige adipocytes. Molecular Endocrinology (Baltimore, Md.). 29: 130-9. PMID 25389910 DOI: 10.1210/me.2014-1295  0.68
2014 Wang W, Kissig M, Rajakumari S, Huang L, Lim HW, Won KJ, Seale P. Ebf2 is a selective marker of brown and beige adipogenic precursor cells. Proceedings of the National Academy of Sciences of the United States of America. 111: 14466-71. PMID 25197048 DOI: 10.1073/pnas.1412685111  0.68
2014 Lim MA, Bence KK, Sandesara I, Andreux P, Auwerx J, Ishibashi J, Seale P, Kalb RG. Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis. Human Molecular Genetics. 23: 4995-5008. PMID 24833719 DOI: 10.1093/hmg/ddu214  0.68
2014 Harms MJ, Ishibashi J, Wang W, Lim HW, Goyama S, Sato T, Kurokawa M, Won KJ, Seale P. Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice. Cell Metabolism. 19: 593-604. PMID 24703692 DOI: 10.1016/j.cmet.2014.03.007  0.68
2014 De Sousa M, Porras DP, Perry CG, Seale P, Scimè A. p107 is a crucial regulator for determining the adipocyte lineage fate choices of stem cells. Stem Cells (Dayton, Ohio). 32: 1323-36. PMID 24449206 DOI: 10.1002/stem.1637  0.68
2014 Cohen P, Levy JD, Zhang Y, Frontini A, Kolodin DP, Svensson KJ, Lo JC, Zeng X, Ye L, Khandekar MJ, Wu J, Gunawardana SC, Banks AS, Camporez JP, Jurczak MJ, ... ... Seale P, et al. Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell. 156: 304-16. PMID 24439384 DOI: 10.1016/j.cell.2013.12.021  0.68
2013 Gerhart-Hines Z, Feng D, Emmett MJ, Everett LJ, Loro E, Briggs ER, Bugge A, Hou C, Ferrara C, Seale P, Pryma DA, Khurana TS, Lazar MA. The nuclear receptor Rev-erbα controls circadian thermogenic plasticity. Nature. 503: 410-3. PMID 24162845 DOI: 10.1038/nature12642  0.68
2013 Harms M, Seale P. Brown and beige fat: development, function and therapeutic potential. Nature Medicine. 19: 1252-63. PMID 24100998 DOI: 10.1038/nm.3361  0.68
2013 Seale P. Brown adipose tissue biology and therapeutic potential. Frontiers in Endocrinology. 4: 14. PMID 23513074 DOI: 10.3389/fendo.2013.00014  0.68
2013 Rajakumari S, Wu J, Ishibashi J, Lim HW, Giang AH, Won KJ, Reed RR, Seale P. EBF2 determines and maintains brown adipocyte identity. Cell Metabolism. 17: 562-74. PMID 23499423 DOI: 10.1016/j.cmet.2013.01.015  0.68
2013 Yin H, Pasut A, Soleimani VD, Bentzinger CF, Antoun G, Thorn S, Seale P, Fernando P, van Ijcken W, Grosveld F, Dekemp RA, Boushel R, Harper ME, Rudnicki MA. MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16. Cell Metabolism. 17: 210-24. PMID 23395168 DOI: 10.1016/j.cmet.2013.01.004  0.68
2012 Derecka M, Gornicka A, Koralov SB, Szczepanek K, Morgan M, Raje V, Sisler J, Zhang Q, Otero D, Cichy J, Rajewsky K, Shimoda K, Poli V, Strobl B, Pellegrini S, ... ... Seale P, et al. Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity. Cell Metabolism. 16: 814-24. PMID 23217260 DOI: 10.1016/j.cmet.2012.11.005  0.68
2012 Ishibashi J, Firtina Z, Rajakumari S, Wood KH, Conroe HM, Steger DJ, Seale P. An Evi1-C/EBPβ complex controls peroxisome proliferator-activated receptor γ2 gene expression to initiate white fat cell differentiation. Molecular and Cellular Biology. 32: 2289-99. PMID 22473998 DOI: 10.1128/MCB.06529-11  0.68
2011 Seale P. Orexin turns up the heat on obesity. Cell Metabolism. 14: 441-2. PMID 21982704 DOI: 10.1016/j.cmet.2011.09.007  0.68
2011 Seale P, Conroe HM, Estall J, Kajimura S, Frontini A, Ishibashi J, Cohen P, Cinti S, Spiegelman BM. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. The Journal of Clinical Investigation. 121: 96-105. PMID 21123942 DOI: 10.1172/JCI44271  0.68
2010 Seale P. Transcriptional control of brown adipocyte development and thermogenesis International Journal of Obesity. 34. PMID 20935660 DOI: 10.1038/ijo.2010.178  0.68
2010 Ishibashi J, Seale P. Medicine. Beige can be slimming. Science (New York, N.Y.). 328: 1113-4. PMID 20448151 DOI: 10.1126/science.1190816  0.68
2010 Kajimura S, Seale P, Spiegelman BM. Transcriptional control of brown fat development. Cell Metabolism. 11: 257-62. PMID 20374957 DOI: 10.1016/j.cmet.2010.03.005  0.68
2010 Gupta RK, Arany Z, Seale P, Mepani RJ, Ye L, Conroe HM, Roby YA, Kulaga H, Reed RR, Spiegelman BM. Transcriptional control of preadipocyte determination by Zfp423. Nature. 464: 619-23. PMID 20200519 DOI: 10.1038/nature08816  0.68
2009 Kajimura S, Seale P, Kubota K, Lunsford E, Frangioni JV, Gygi SP, Spiegelman BM. Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature. 460: 1154-8. PMID 19641492 DOI: 10.1038/nature08262  0.68
2009 Seale P, Lazar MA. Brown fat in humans: turning up the heat on obesity. Diabetes. 58: 1482-4. PMID 19564460 DOI: 10.2337/db09-0622  0.68
2009 Seale P, Kajimura S, Spiegelman BM. Transcriptional control of brown adipocyte development and physiological function--of mice and men. Genes & Development. 23: 788-97. PMID 19339685 DOI: 10.1101/gad.1779209  0.68
2008 Seale P, Bjork B, Yang W, Kajimura S, Chin S, Kuang S, Scimè A, Devarakonda S, Conroe HM, Erdjument-Bromage H, Tempst P, Rudnicki MA, Beier DR, Spiegelman BM. PRDM16 controls a brown fat/skeletal muscle switch. Nature. 454: 961-7. PMID 18719582 DOI: 10.1038/nature07182  0.68
2008 Kajimura S, Seale P, Tomaru T, Erdjument-Bromage H, Cooper MP, Ruas JL, Chin S, Tempst P, Lazar MA, Spiegelman BM. Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes & Development. 22: 1397-409. PMID 18483224 DOI: 10.1101/gad.1666108  0.68
2007 Holterman CE, Le Grand F, Kuang S, Seale P, Rudnicki MA. Megf10 regulates the progression of the satellite cell myogenic program. The Journal of Cell Biology. 179: 911-22. PMID 18056409 DOI: 10.1083/jcb.200709083  0.68
2007 Seale P, Kajimura S, Yang W, Chin S, Rohas LM, Uldry M, Tavernier G, Langin D, Spiegelman BM. Transcriptional control of brown fat determination by PRDM16. Cell Metabolism. 6: 38-54. PMID 17618855 DOI: 10.1016/j.cmet.2007.06.001  0.68
2007 Handschin C, Kobayashi YM, Chin S, Seale P, Campbell KP, Spiegelman BM. PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy. Genes & Development. 21: 770-83. PMID 17403779 DOI: 10.1101/gad.1525107  0.68
2006 Uldry M, Yang W, St-Pierre J, Lin J, Seale P, Spiegelman BM. Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. Cell Metabolism. 3: 333-41. PMID 16679291 DOI: 10.1016/j.cmet.2006.04.002  0.68
2006 Kuang S, Chargé SB, Seale P, Huh M, Rudnicki MA. Distinct roles for Pax7 and Pax3 in adult regenerative myogenesis. The Journal of Cell Biology. 172: 103-13. PMID 16391000 DOI: 10.1083/jcb.200508001  0.68
2006 Uldry M, Yang W, St-Pierre J, Lin J, Seale P, Spiegelman BM. Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation (DOI:10.1016/j.cmet.2006.04.002) Cell Metabolism. 4: 97. DOI: 10.1016/j.cmet.2006.06.005  0.68
2004 Seale P, Ishibashi J, Holterman C, Rudnicki MA. Muscle satellite cell-specific genes identified by genetic profiling of MyoD-deficient myogenic cell. Developmental Biology. 275: 287-300. PMID 15501219 DOI: 10.1016/j.ydbio.2004.07.034  0.68
2004 Seale P, Ishibashi J, Scimè A, Rudnicki MA. Pax7 is necessary and sufficient for the myogenic specification of CD45+:Sca1+ stem cells from injured muscle. Plos Biology. 2: E130. PMID 15138500 DOI: 10.1371/journal.pbio.0020130  0.68
2003 Seale P, Polesskaya A, Rudnicki MA. Adult stem cell specification by Wnt signaling in muscle regeneration. Cell Cycle (Georgetown, Tex.). 2: 418-9. PMID 12963830  0.68
2003 Parker MH, Seale P, Rudnicki MA. Looking back to the embryo: defining transcriptional networks in adult myogenesis. Nature Reviews. Genetics. 4: 497-507. PMID 12838342 DOI: 10.1038/nrg1109  0.68
2003 Polesskaya A, Seale P, Rudnicki MA. Wnt signaling induces the myogenic specification of resident CD45+ adult stem cells during muscle regeneration. Cell. 113: 841-52. PMID 12837243 DOI: 10.1016/S0092-8674(03)00437-9  0.68
2002 Hierlihy AM, Seale P, Lobe CG, Rudnicki MA, Megeney LA. The post-natal heart contains a myocardial stem cell population. Febs Letters. 530: 239-43. PMID 12387899 DOI: 10.1016/S0014-5793(02)03477-4  0.68
2002 Asakura A, Seale P, Girgis-Gabardo A, Rudnicki MA. Myogenic specification of side population cells in skeletal muscle. The Journal of Cell Biology. 159: 123-34. PMID 12379804 DOI: 10.1083/jcb.200202092  0.68
2002 Seale P, Rudnicki MA. Adult skeletal muscle growth and regeneration: The development and differentiation of myogenic stem cells Advances in Cell Aging and Gerontology. 9: 177-200.  0.68
2001 Seale P, Asakura A, Rudnicki MA. The Potential of Muscle Stem Cells Developmental Cell. 1: 333-342. PMID 11702945 DOI: 10.1016/S1534-5807(01)00049-1  0.68
2001 Kolodziejczyk SM, Walsh GS, Balazsi K, Seale P, Sandoz J, Hierlihy AM, Rudnicki MA, Chamberlain JS, Miller FD, Megeney LA. Activation of JNK1 contributes to dystrophic muscle pathogenesis Current Biology. 11: 1278-1282. PMID 11525743 DOI: 10.1016/S0960-9822(01)00397-9  0.68
2000 Seale P, Sabourin LA, Girgis-Gabardo A, Mansouri A, Gruss P, Rudnicki MA. Pax7 is required for the specification of myogenic satellite cells. Cell. 102: 777-86. PMID 11030621  0.68
2000 Seale P, Rudnicki MA. A new look at the origin, function, and 'stem-cell' status of muscle satellite cells Developmental Biology. 218: 115-124. PMID 10656756 DOI: 10.1006/dbio.1999.9565  0.68
2000 Sabourin LA, Seale P, Wagner J, Rudnicki MA. Caspase 3 cleavage of the Ste20-related kinase SLK releases and activates an apoptosis-inducing kinase domain and an actin-disassembling region Molecular and Cellular Biology. 20: 684-696. PMID 10611247 DOI: 10.1128/MCB.20.2.684-696.2000  0.68
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