Michael R. Betts - Publications

Affiliations: 
Cell and Molecular Biology University of Pennsylvania, Philadelphia, PA, United States 
Area:
Immunology, Virology Biology, General

112 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Johnson JL, Rosenthal RL, Knox JJ, Myles A, Naradikian MS, Madej J, Kostiv M, Rosenfeld AM, Meng W, Christensen SR, Hensley SE, Yewdell J, Canaday DH, Zhu J, McDermott AB, ... ... Betts MR, et al. The Transcription Factor T-bet Resolves Memory B Cell Subsets with Distinct Tissue Distributions and Antibody Specificities in Mice and Humans. Immunity. PMID 32353250 DOI: 10.1016/j.immuni.2020.03.020  0.4
2018 Buggert M, Nguyen S, McLane LM, Steblyanko M, Anikeeva N, Paquin-Proulx D, Del Rio Estrada PM, Ablanedo-Terrazas Y, Noyan K, Reuter MA, Demers K, Sandberg J, Eller MA, Streeck H, Jansson M, ... ... Betts MR, et al. Limited immune surveillance in lymphoid tissue by cytolytic CD4+ T cells during health and HIV disease. Plos Pathogens. 14: e1006973. PMID 29652923 DOI: 10.1371/journal.ppat.1006973  0.4
2017 Knox JJ, Kaplan DE, Betts MR. T-bet-expressing B cells during HIV and HCV infections. Cellular Immunology. PMID 28739077 DOI: 10.1016/j.cellimm.2017.04.012  0.4
2017 Knox JJ, Buggert M, Kardava L, Seaton KE, Eller MA, Canaday DH, Robb ML, Ostrowski MA, Deeks SG, Slifka MK, Tomaras GD, Moir S, Moody MA, Betts MR. T-bet+ B cells are induced by human viral infections and dominate the HIV gp140 response. Jci Insight. 2. PMID 28422752 DOI: 10.1172/jci.insight.92943  0.4
2016 Knox JJ, Cosma GL, Betts MR, McLane LM. Corrigendum: Characterization of T-bet and Eomes in Peripheral Human Immune Cells. Frontiers in Immunology. 7: 337. PMID 27610109 DOI: 10.3389/fimmu.2016.00337  0.4
2016 Demers KR, Makedonas G, Buggert M, Eller MA, Ratcliffe SJ, Goonetilleke N, Li CK, Eller LA, Rono K, Maganga L, Nitayaphan S, Kibuuka H, Routy JP, Slifka MK, Haynes BF, ... ... Betts MR, et al. Temporal Dynamics of CD8+ T Cell Effector Responses during Primary HIV Infection. Plos Pathogens. 12: e1005805. PMID 27486665 DOI: 10.1371/journal.ppat.1005805  0.44
2015 Pombo C, Wherry EJ, Gostick E, Price DA, Betts MR. Elevated Expression of CD160 and 2B4 Defines a Cytolytic HIV-Specific CD8+ T-Cell Population in Elite Controllers. The Journal of Infectious Diseases. PMID 25883386 DOI: 10.1093/infdis/jiv226  0.44
2015 Van Epps P, Sridaran S, Aung H, Wilson BM, Burant CJ, Nserko M, Mayanja-Kizza H, Betts MR, Toossi Z, Canaday DH. CD4 T-cell cytokine correlates of diagnostic tests for latent tuberculous infection in HIV-1-infected subjects International Journal of Tuberculosis and Lung Disease. 19: 927-935. DOI: 10.5588/ijtld.14.0896  0.44
2015 Canaday DH, Sridaran S, Van Epps P, Aung H, Burant CJ, Nsereko M, Mayanja-Kizza H, Betts MR, Toossi Z. CD4+ T cell polyfunctional profile in HIV-TB coinfection are similar between individuals with latent and active TB infection Tuberculosis. 95: 470-475. DOI: 10.1016/j.tube.2014.12.008  0.44
2014 Van Epps P, Banks R, Aung H, Betts MR, Canaday DH. Age-related differences in polyfunctional T cell responses. Immunity & Ageing : I & A. 11: 14. PMID 25512758 DOI: 10.1186/1742-4933-11-14  0.44
2014 Herati RS, Reuter MA, Dolfi DV, Mansfield KD, Aung H, Badwan OZ, Kurupati RK, Kannan S, Ertl H, Schmader KE, Betts MR, Canaday DH, Wherry EJ. Circulating CXCR5+PD-1+response predicts influenza vaccine antibody responses in young adults but not elderly adults Journal of Immunology. 193: 3528-3537. PMID 25172499 DOI: 10.4049/jimmunol.1302503  0.44
2014 Christian DA, Koshy AA, Reuter MA, Betts MR, Boothroyd JC, Hunter CA. Use of transgenic parasites and host reporters to dissect events that promote interleukin-12 production during toxoplasmosis. Infection and Immunity. 82: 4056-67. PMID 25024368 DOI: 10.1128/IAI.01643-14  0.44
2014 Knox JJ, Cosma GL, Betts MR, McLane LM. Characterization of T-bet and eomes in peripheral human immune cells. Frontiers in Immunology. 5: 217. PMID 24860576 DOI: 10.3389/fimmu.2014.00217  0.4
2014 Bukh I, Calcedo R, Roy S, Carnathan DG, Grant R, Qin Q, Boyd S, Ratcliffe SJ, Veeder CL, Bellamy SL, Betts MR, Wilson JM. Increased mucosal CD4+ T cell activation in rhesus macaques following vaccination with an adenoviral vector. Journal of Virology. 88: 8468-78. PMID 24829340 DOI: 10.1128/JVI.03850-13  0.44
2014 Dupont CD, Christian DA, Selleck EM, Pepper M, Leney-Greene M, Harms Pritchard G, Koshy AA, Wagage S, Reuter MA, Sibley LD, Betts MR, Hunter CA. Parasite fate and involvement of infected cells in the induction of CD4+ and CD8+ T cell responses to Toxoplasma gondii. Plos Pathogens. 10: e1004047. PMID 24722202 DOI: 10.1371/journal.ppat.1004047  0.44
2014 Hope TJ, Betts MR. Commentary on shapiro: Clinical development of candidate HIV vaccines: Different problems for different vaccines Aids Research and Human Retroviruses. 30: 330. PMID 24620907 DOI: 10.1089/aid.2014.0047  0.44
2014 Knox JJ, Cosma GL, Betts MR, McLane LM. Characterization of T-bet and Eomes in peripheral human immune cells Frontiers in Immunology. 5. DOI: 10.3389/fimmu.2014.00217  0.44
2014 Buggert M, Tauriainen J, Yamamoto T, Frederiksen J, Ivarsson MA, Michaëlsson J, Lund O, Hejdeman B, Jansson M, Sönnerborg A, Koup RA, Betts MR, Karlsson AC. T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+ T Cells in HIV Infection Plos Pathogens. 10. DOI: 10.1371/journal.ppat.1004251  0.44
2014 Van Epps P, Banks R, Aung H, Betts MR, Canaday DH. Age-related differences in polyfunctional T cell responses Immunity and Ageing. 11. DOI: 10.1186/1742-4933-11-14.  0.44
2013 Manuel SL, Sehgal M, Connolly J, Makedonas G, Khan ZK, Gardner J, Betts MR, Jain P. Lack of recall response to Tax in ATL and HAM/TSP patients but not in asymptomatic carriers of human T-cell leukemia virus type 1. Journal of Clinical Immunology. 33: 1223-39. PMID 23888327 DOI: 10.1007/s10875-013-9918-x  0.44
2013 Novais FO, Carvalho LP, Graff JW, Beiting DP, Ruthel G, Roos DS, Betts MR, Goldschmidt MH, Wilson ME, de Oliveira CI, Scott P. Cytotoxic T cells mediate pathology and metastasis in cutaneous leishmaniasis. Plos Pathogens. 9: e1003504. PMID 23874205 DOI: 10.1371/journal.ppat.1003504  0.44
2013 Demers KR, Reuter MA, Betts MR. CD8+ T-cell effector function and transcriptional regulation during HIV pathogenesis Immunological Reviews. 254: 190-206. PMID 23772621 DOI: 10.1111/imr.12069  0.44
2013 Manuel SL, Sehgal M, Khan ZK, Goedert JJ, Betts MR, Jain P. An altered maturation and adhesion phenotype of dendritic cells in diseased individuals compared to asymptomatic carriers of human T cell leukemia virus type 1. Aids Research and Human Retroviruses. 29: 1273-85. PMID 23750452 DOI: 10.1089/AID.2013.0054  0.44
2013 Frentsch M, Stark R, Matzmohr N, Meier S, Durlanik S, Schulz AR, Stervbo U, Jürchott K, Gebhardt F, Heine G, Reuter MA, Betts MR, Busch D, Thiel A. CD40L expression permits CD8+ T cells to execute immunologic helper functions. Blood. 122: 405-412. PMID 23719298 DOI: 10.1182/blood-2013-02-483586  0.44
2013 McLane LM, Banerjee PP, Cosma GL, Makedonas G, Wherry EJ, Orange JS, Betts MR. Differential localization of T-bet and Eomes in CD8 T cell memory populations Journal of Immunology. 190: 3207-3215. PMID 23455505 DOI: 10.4049/jimmunol.1201556  0.44
2012 Lelic A, Verschoor CP, Ventresca M, Parsons R, Evelegh C, Bowdish D, Betts MR, Loeb MB, Bramson JL. The polyfunctionality of human memory CD8+ T cells elicited by acute and chronic virus infections is not influenced by age. Plos Pathogens. 8: e1003076. PMID 23271970 DOI: 10.1371/journal.ppat.1003076  0.44
2012 Kathuria N, Kraynyak KA, Carnathan D, Betts M, Weiner DB, Kutzler MA. Generation of antigen-specific immunity following systemic immunization with DNA vaccine encoding CCL25 chemokine immunoadjuvant. Human Vaccines & Immunotherapeutics. 8: 1607-19. PMID 23151454 DOI: 10.4161/hv.22574  0.44
2012 Reuter MA, Yuan S, Marx PA, Kutzler MA, Weiner DB, Betts MR. DNA-based HIV vaccines do not induce generalized activation in mucosal tissue T cells. Human Vaccines & Immunotherapeutics. 8: 1648-53. PMID 23111167 DOI: 10.4161/hv.22247  0.44
2012 Reuter MA, Pombo C, Betts MR. Cytokine production and dysregulation in HIV pathogenesis: Lessons for development of therapeutics and vaccines Cytokine and Growth Factor Reviews. 23: 181-191. PMID 22743036 DOI: 10.1016/j.cytogfr.2012.05.005  0.44
2012 Parrish NF, Wilen CB, Banks LB, Iyer SS, Pfaff JM, Salazar-Gonzalez JF, Salazar MG, Decker JM, Parrish EH, Berg A, Hopper J, Hora B, Kumar A, Mahlokozera T, Yuan S, ... ... Betts MR, et al. Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7 Plos Pathogens. 8. PMID 22693444 DOI: 10.1371/journal.ppat.1002686  0.44
2012 Chattopadhyay PK, Gaylord B, Palmer A, Jiang N, Raven MA, Lewis G, Reuter MA, Nur-ur Rahman AK, Price DA, Betts MR, Roederer M. Brilliant violet fluorophores: a new class of ultrabright fluorescent compounds for immunofluorescence experiments. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 81: 456-66. PMID 22489009 DOI: 10.1002/cyto.a.22043  0.44
2012 Riou C, Ganusov VV, Campion S, Mlotshwa M, Liu MK, Whale VE, Goonetilleke N, Borrow P, Ferrari G, Betts MR, Haynes BF, McMichael AJ, Gray CM. Distinct kinetics of Gag-specific CD4+ and CD8+ T cell responses during acute HIV-1 infection. Journal of Immunology (Baltimore, Md. : 1950). 188: 2198-206. PMID 22287716 DOI: 10.4049/jimmunol.1102813  0.44
2012 van Montfrans JM, Hoepelman AI, Otto S, van Gijn M, van de Corput L, de Weger RA, Monaco-Shawver L, Banerjee PP, Sanders EA, Jol-van der Zijde CM, Betts MR, Orange JS, Bloem AC, Tesselaar K. CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia. The Journal of Allergy and Clinical Immunology. 129: 787-793.e6. PMID 22197273 DOI: 10.1016/j.jaci.2011.11.013  0.44
2011 Vanderford TH, Bleckwehl C, Engram JC, Dunham RM, Klatt NR, Feinberg MB, Garber DA, Betts MR, Silvestri G. Viral CTL escape mutants are generated in lymph nodes and subsequently become fixed in plasma and rectal mucosa during acute SIV infection of macaques. Plos Pathogens. 7: e1002048. PMID 21625590 DOI: 10.1371/journal.ppat.1002048  0.44
2011 Haney D, Quigley MF, Asher TE, Ambrozak DR, Gostick E, Price DA, Douek DC, Betts MR. Isolation of viable antigen-specific CD8+ T cells based on membrane-bound tumor necrosis factor (TNF)-α expression. Journal of Immunological Methods. 369: 33-41. PMID 21501617 DOI: 10.1016/j.jim.2011.04.003  0.44
2011 El Fenniri L, Toossi Z, Aung H, El Iraki G, Bourkkadi J, Benamor J, Laskri A, Berrada N, Benjouad A, Mayanja-Kizza H, Betts MR, El Aouad R, Canaday DH. Polyfunctional Mycobacterium tuberculosis-specific effector memory CD4+ T cells at sites of pleural TB. Tuberculosis (Edinburgh, Scotland). 91: 224-30. PMID 21459675 DOI: 10.1016/j.tube.2010.12.005  0.44
2011 Hersperger AR, Migueles SA, Betts MR, Connors M. Qualitative features of the HIV-specific CD8+ T-cell response associated with immunologic control. Current Opinion in Hiv and Aids. 6: 169-73. PMID 21399496 DOI: 10.1097/COH.0b013e3283454c39  0.44
2011 Ferrari G, Korber B, Goonetilleke N, Liu MK, Turnbull EL, Salazar-Gonzalez JF, Hawkins N, Self S, Watson S, Betts MR, Gay C, McGhee K, Pellegrino P, Williams I, Tomaras GD, et al. Relationship between functional profile of HIV-1 specific CD8 T cells and epitope variability with the selection of escape mutants in acute HIV-1 infection. Plos Pathogens. 7: e1001273. PMID 21347345 DOI: 10.1371/journal.ppat.1001273  0.44
2011 Hersperger AR, Martin JN, Shin LY, Sheth PM, Kovacs CM, Cosma GL, Makedonas G, Pereyra F, Walker BD, Kaul R, Deeks SG, Betts MR. Increased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression. Blood. 117: 3799-808. PMID 21289310 DOI: 10.1182/blood-2010-12-322727  0.44
2011 Makedonas G, Betts MR. Living in a house of cards: re-evaluating CD8+ T-cell immune correlates against HIV. Immunological Reviews. 239: 109-24. PMID 21198668 DOI: 10.1111/j.1600-065X.2010.00968.x  0.44
2011 Lasaro MO, Haut LH, Zhou X, Xiang Z, Zhou D, Li Y, Giles-Davis W, Li H, Engram JC, Dimenna LJ, Bian A, Sazanovich M, Parzych EM, Kurupati R, Small JC, ... ... Betts MR, et al. Vaccine-induced T cells provide partial protection against high-dose rectal SIVmac239 challenge of rhesus macaques. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 417-26. PMID 21081905 DOI: 10.1038/mt.2010.238  0.44
2010 Hutnick NA, Carnathan DG, Dubey SA, Cox KS, Kierstead L, Makadonas G, Ratcliffe SJ, Lasaro MO, Robertson MN, Casimiro DR, Ertl HC, Betts MR. Vaccination with Ad5 vectors expands Ad5-specific CD8 T cells without altering memory phenotype or functionality. Plos One. 5: e14385. PMID 21203546 DOI: 10.1371/journal.pone.0014385  0.44
2010 Chen H, Xiang ZQ, Li Y, Kurupati RK, Jia B, Bian A, Zhou DM, Hutnick N, Yuan S, Gray C, Serwanga J, Auma B, Kaleebu P, Zhou X, Betts MR, et al. Adenovirus-based vaccines: comparison of vectors from three species of adenoviridae. Journal of Virology. 84: 10522-32. PMID 20686035 DOI: 10.1128/JVI.00450-10  0.44
2010 Hirao LA, Wu L, Satishchandran A, Khan AS, Draghia-Akli R, Finnefrock AC, Bett AJ, Betts MR, Casimiro DR, Sardesai NY, Kim JJ, Shiver JW, Weiner DB. Comparative analysis of immune responses induced by vaccination with SIV antigens by recombinant Ad5 vector or plasmid DNA in rhesus macaques. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 1568-76. PMID 20551910 DOI: 10.1038/mt.2010.112  0.44
2010 Hersperger AR, Pereyra F, Nason M, Demers K, Sheth P, Shin LY, Kovacs CM, Rodriguez B, Sieg SF, Teixeira-Johnson L, Gudonis D, Goepfert PA, Lederman MM, Frank I, Makedonas G, ... ... Betts MR, et al. Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control. Plos Pathogens. 6: e1000917. PMID 20523897 DOI: 10.1371/journal.ppat.1000917  0.44
2010 Makedonas G, Hutnick N, Haney D, Amick AC, Gardner J, Cosma G, Hersperger AR, Dolfi D, Wherry EJ, Ferrari G, Betts MR. Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells. Plos Pathogens. 6: e1000798. PMID 20221423 DOI: 10.1371/journal.ppat.1000798  0.44
2010 Hutnick NA, Carnathan D, Demers K, Makedonas G, Ertl HC, Betts MR. Adenovirus-specific human T cells are pervasive, polyfunctional, and cross-reactive. Vaccine. 28: 1932-41. PMID 20188249 DOI: 10.1016/j.vaccine.2009.10.091  0.44
2009 Casazza JP, Brenchley JM, Hill BJ, Ayana R, Ambrozak D, Roederer M, Douek DC, Betts MR, Koup RA. Autocrine production of beta-chemokines protects CMV-Specific CD4 T cells from HIV infection. Plos Pathogens. 5: e1000646. PMID 19876388 DOI: 10.1371/journal.ppat.1000646  0.44
2009 Brantly ML, Chulay JD, Wang L, Mueller C, Humphries M, Spencer LT, Rouhani F, Conlon TJ, Calcedo R, Betts MR, Spencer C, Byrne BJ, Wilson JM, Flotte TR. Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy. Proceedings of the National Academy of Sciences of the United States of America. 106: 16363-8. PMID 19706466 DOI: 10.1073/pnas.0904514106  0.44
2009 Hutnick NA, Carnathan DG, Dubey SA, Makedonas G, Cox KS, Kierstead L, Ratcliffe SJ, Robertson MN, Casimiro DR, Ertl HC, Betts MR. Baseline Ad5 serostatus does not predict Ad5 HIV vaccine-induced expansion of adenovirus-specific CD4+ T cells. Nature Medicine. 15: 876-8. PMID 19620962 DOI: 10.1038/nm.1989  0.44
2009 O'Brien KL, Liu J, King SL, Sun YH, Schmitz JE, Lifton MA, Hutnick NA, Betts MR, Dubey SA, Goudsmit J, Shiver JW, Robertson MN, Casimiro DR, Barouch DH. Adenovirus-specific immunity after immunization with an Ad5 HIV-1 vaccine candidate in humans. Nature Medicine. 15: 873-5. PMID 19620961 DOI: 10.1038/nm.1991  0.44
2009 Engram JC, Dunham RM, Makedonas G, Vanderford TH, Sumpter B, Klatt NR, Ratcliffe SJ, Garg S, Paiardini M, McQuoid M, Altman JD, Staprans SI, Betts MR, Garber DA, Feinberg MB, et al. Vaccine-induced, simian immunodeficiency virus-specific CD8+ T cells reduce virus replication but do not protect from simian immunodeficiency virus disease progression. Journal of Immunology (Baltimore, Md. : 1950). 183: 706-17. PMID 19542473 DOI: 10.4049/jimmunol.0803746  0.44
2009 Mingozzi F, Meulenberg JJ, Hui DJ, Basner-Tschakarjan E, Hasbrouck NC, Edmonson SA, Hutnick NA, Betts MR, Kastelein JJ, Stroes ES, High KA. AAV-1-mediated gene transfer to skeletal muscle in humans results in dose-dependent activation of capsid-specific T cells. Blood. 114: 2077-86. PMID 19506302 DOI: 10.1182/blood-2008-07-167510  0.44
2009 Sanborn KB, Rak GD, Maru SY, Demers K, Difeo A, Martignetti JA, Betts MR, Favier R, Banerjee PP, Orange JS. Myosin IIA associates with NK cell lytic granules to enable their interaction with F-actin and function at the immunological synapse. Journal of Immunology (Baltimore, Md. : 1950). 182: 6969-84. PMID 19454694 DOI: 10.4049/jimmunol.0804337  0.44
2009 Tatsis N, Lasaro MO, Lin SW, Haut LH, Xiang ZQ, Zhou D, Dimenna L, Li H, Bian A, Abdulla S, Li Y, Giles-Davis W, Engram J, Ratcliffe SJ, Silvestri G, ... ... Betts MR, et al. Adenovirus vector-induced immune responses in nonhuman primates: responses to prime boost regimens. Journal of Immunology (Baltimore, Md. : 1950). 182: 6587-99. PMID 19414814 DOI: 10.4049/jimmunol.0900317  0.44
2009 Makedonas G, Banerjee PP, Pandey R, Hersperger AR, Sanborn KB, Hardy GA, Orange JS, Betts MR. Rapid up-regulation and granule-independent transport of perforin to the immunological synapse define a novel mechanism of antigen-specific CD8+ T cell cytotoxic activity. Journal of Immunology (Baltimore, Md. : 1950). 182: 5560-9. PMID 19380804 DOI: 10.4049/jimmunol.0803945  0.44
2009 Blackburn SD, Shin H, Haining WN, Zou T, Workman CJ, Polley A, Betts MR, Freeman GJ, Vignali DA, Wherry EJ. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nature Immunology. 10: 29-37. PMID 19043418 DOI: 10.1038/ni.1679  0.44
2009 Chattopadhyay PK, Betts MR, Price DA, Gostick E, Horton H, Roederer M, De Rosa SC. The cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression. Journal of Leukocyte Biology. 85: 88-97. PMID 18820174 DOI: 10.1189/jlb.0208107  0.44
2009 Tatsis N, Lasaro MO, Lin SW, Haut LH, Xiang ZQ, Zhou D, DiMenna L, Li H, Bian A, Abdulla S, Li Y, Giles-Davis W, Engram J, Ratcliffe SJ, Silvestri G, ... ... Betts MR, et al. Adenovirus vector-induced immune responses in nonhuman primates: Responses to prime boost regimens (Journal of Immunology (2009) 182, (6587-6599)) Journal of Immunology. 183: 7611. DOI: 10.4049/jimmunol.0990099  0.44
2009 Kraynyak KA, Kutzler MA, Pahar B, Sylvester A, Yan J, Carnathan D, Khan AS, Sardesai N, Moldoveanu Z, Mestecky J, Betts MR, Marx P, Weiner DB. P19-46. Co-delivery of mucosal chemokine plasmids in a systemically delivered DNA vaccine elicits systemic and mucosal immune responses in mice and macaques Retrovirology. 6: P366. DOI: 10.1186/1742-4690-6-S3-P366  0.44
2009 Hutnick N, Carnathan D, Dubey S, Cox K, Ratcliffe S, Robertson MN, Casimiro DR, Ertl HC, Betts MR. P16-09. Adenovirus 5 vector HIV vaccination does not affect mucosal homing markers on Ad5-specific CD4+ T-cells in humans Retrovirology. 6: P238. DOI: 10.1186/1742-4690-6-S3-P238  0.44
2009 Hersperger AR, Pereyra F, Demers K, Sheth P, Shin LY, Rodriguez B, Sieg SF, Teixeira-Johnson L, Goepfert PA, Lederman MM, Kaul R, Makedonas G, Walker BD, Betts MR. S03-06 OA. Rapid perforin upregulation by CD8 T cells in elite controllers as a correlate of immune-mediated control of HIV replication Retrovirology. 6: O45. DOI: 10.1186/1742-4690-6-S3-O45  0.44
2009 Hirao LA, Wu L, Satishchandran A, Khan AS, Finnefrock A, Casimiro D, Shiver J, Betts MR, Sardesai NY, Weiner DB. OA05-02. Analysis of DNA compared to Ad5 vaccination, as single and mixed modalities, demonstrates robust induction of cellular immune responses in macaques Retrovirology. 6: O32. DOI: 10.1186/1742-4690-6-S3-O32  0.44
2009 Brantly ML, Chulay JD, Lili W, Mueller C, Humphries M, Spencer LT, Rouhani F, Conlon TJ, Calcedo R, Betts MR, Spencer C, Byrne BJ, Wilson JM, Flotte TR. Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy (Proceedings of the National Academy of Sciences of the United States of America (2009) 106, 38, (16363-16368) DOI: 10.1073/pnas.0904514106) Proceedings of the National Academy of Sciences of the United States of America. 106: 17605. DOI: 10.1073/pnas.0909220106  0.44
2009 Makedonas G, Frank I, Guidonis D, Ostrowski MA, Weinhold KJ, Betts MR. P01-05. Rapid perforin upregulation dominates the HIV-specific CD8 T cell response during acute HIV-infection Retrovirology. 6.  0.44
2009 Hirao LA, Wu L, Khan AS, Dai A, Karl J, Lank S, Wiseman R, O'Connor D, Watkins D, Miller N, Betts MR, Sardesai NY, Boyer JD, Weiner DB. P03-11. DNA vaccination with IL-12 lowers viral replication following SIVmac251 challenge Retrovirology. 6: P28.  0.44
2008 Betts MR, Harari A. Phenotype and function of protective T cell immune responses in HIV. Current Opinion in Hiv and Aids. 3: 349-55. PMID 19372989 DOI: 10.1097/COH.0b013e3282fbaa81  0.44
2008 Vali B, Yue FY, Jones RB, Sheth PM, Kaul R, Betts MR, Wong D, Kovacs C, Loutfy M, Common A, Halpenny R, Ostrowski MA. HIV-specific T-cells accumulate in the liver in HCV/HIV co-infection. Plos One. 3: e3454. PMID 18941622 DOI: 10.1371/journal.pone.0003454  0.44
2008 Hersperger AR, Makedonas G, Betts MR. Flow cytometric detection of perforin upregulation in human CD8 T cells. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 73: 1050-7. PMID 18615597 DOI: 10.1002/cyto.a.20596  0.44
2008 Hirao LA, Wu L, Khan AS, Hokey DA, Yan J, Dai A, Betts MR, Draghia-Akli R, Weiner DB. Combined effects of IL-12 and electroporation enhances the potency of DNA vaccination in macaques. Vaccine. 26: 3112-20. PMID 18430495 DOI: 10.1016/j.vaccine.2008.02.036  0.44
2008 Hokey DA, Johnson FB, Smith J, Weber JL, Yan J, Hirao L, Boyer JD, Lewis MG, Makedonas G, Betts MR, Weiner DB. Activation drives PD-1 expression during vaccine-specific proliferation and following lentiviral infection in macaques. European Journal of Immunology. 38: 1435-45. PMID 18389475 DOI: 10.1002/eji.200737857  0.44
2008 Daucher M, Price DA, Brenchley JM, Lamoreaux L, Metcalf JA, Rehm C, Nies-Kraske E, Urban E, Yoder C, Rock D, Gumkowski J, Betts MR, Dybul MR, Douek DC. Virological outcome after structured interruption of antiretroviral therapy for human immunodeficiency virus infection is associated with the functional profile of virus-specific CD8+ T cells. Journal of Virology. 82: 4102-14. PMID 18234797 DOI: 10.1128/JVI.02212-07  0.44
2007 Precopio ML, Betts MR, Parrino J, Price DA, Gostick E, Ambrozak DR, Asher TE, Douek DC, Harari A, Pantaleo G, Bailer R, Graham BS, Roederer M, Koup RA. Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8(+) T cell responses. The Journal of Experimental Medicine. 204: 1405-16. PMID 17535971 DOI: 10.1084/jem.20062363  0.44
2006 Casazza JP, Betts MR, Price DA, Precopio ML, Ruff LE, Brenchley JM, Hill BJ, Roederer M, Douek DC, Koup RA. Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation. The Journal of Experimental Medicine. 203: 2865-77. PMID 17158960 DOI: 10.1084/jem.20052246  0.44
2006 Betts MR, Gray CM, Cox JH, Ferrari G. Antigen-specific T-cell-mediated immunity after HIV-1 infection: implications for vaccine control of HIV development. Expert Review of Vaccines. 5: 505-16. PMID 16989631 DOI: 10.1586/14760584.5.4.505  0.44
2006 Makedonas G, Betts MR. Polyfunctional analysis of human t cell responses: importance in vaccine immunogenicity and natural infection. Springer Seminars in Immunopathology. 28: 209-19. PMID 16932955 DOI: 10.1007/s00281-006-0025-4  0.44
2006 Hryniewicz A, Boasso A, Edghill-Smith Y, Vaccari M, Fuchs D, Venzon D, Nacsa J, Betts MR, Tsai WP, Heraud JM, Beer B, Blanset D, Chougnet C, Lowy I, Shearer GM, et al. CTLA-4 blockade decreases TGF-beta, IDO, and viral RNA expression in tissues of SIVmac251-infected macaques. Blood. 108: 3834-42. PMID 16896154 DOI: 10.1182/blood-2006-04-010637  0.44
2006 Chattopadhyay PK, Price DA, Harper TF, Betts MR, Yu J, Gostick E, Perfetto SP, Goepfert P, Koup RA, De Rosa SC, Bruchez MP, Roederer M. Quantum dot semiconductor nanocrystals for immunophenotyping by polychromatic flow cytometry. Nature Medicine. 12: 972-7. PMID 16862156 DOI: 10.1038/nm1371  0.44
2006 Betts MR, Nason MC, West SM, De Rosa SC, Migueles SA, Abraham J, Lederman MM, Benito JM, Goepfert PA, Connors M, Roederer M, Koup RA. HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells. Blood. 107: 4781-9. PMID 16467198 DOI: 10.1182/blood-2005-12-4818  0.44
2005 Price DA, Brenchley JM, Ruff LE, Betts MR, Hill BJ, Roederer M, Koup RA, Migueles SA, Gostick E, Wooldridge L, Sewell AK, Connors M, Douek DC. Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses. The Journal of Experimental Medicine. 202: 1349-61. PMID 16287711 DOI: 10.1084/jem.20051357  0.44
2005 Podsakoff GM, Engel BC, Carbonaro DA, Choi C, Smogorzewska EM, Bauer G, Selander D, Csik S, Wilson K, Betts MR, Koup RA, Nabel GJ, Bishop K, King S, Schmidt M, et al. Selective survival of peripheral blood lymphocytes in children with HIV-1 following delivery of an anti-HIV gene to bone marrow CD34(+) cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 12: 77-86. PMID 15963923 DOI: 10.1016/j.ymthe.2005.02.024  0.44
2005 Betts MR, Exley B, Price DA, Bansal A, Camacho ZT, Teaberry V, West SM, Ambrozak DR, Tomaras G, Roederer M, Kilby JM, Tartaglia J, Belshe R, Gao F, Douek DC, et al. Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection. Proceedings of the National Academy of Sciences of the United States of America. 102: 4512-7. PMID 15753288 DOI: 10.1073/pnas.0408773102  0.44
2005 Casazza JP, Betts MR, Hill BJ, Brenchley JM, Price DA, Douek DC, Koup RA. Immunologic pressure within class I-restricted cognate human immunodeficiency virus epitopes during highly active antiretroviral therapy. Journal of Virology. 79: 3653-63. PMID 15731259 DOI: 10.1128/JVI.79.6.3653-3663.2005  0.44
2004 Betts MR, Koup RA. Detection of T-cell degranulation: CD107a and b. Methods in Cell Biology. 75: 497-512. PMID 15603439 DOI: 10.1016/S0091-679X(04)75020-7  0.44
2004 Price DA, West SM, Betts MR, Ruff LE, Brenchley JM, Ambrozak DR, Edghill-Smith Y, Kuroda MJ, Bogdan D, Kunstman K, Letvin NL, Franchini G, Wolinsky SM, Koup RA, Douek DC. T cell receptor recognition motifs govern immune escape patterns in acute SIV infection. Immunity. 21: 793-803. PMID 15589168 DOI: 10.1016/j.immuni.2004.10.010  0.44
2004 Ferrari G, Neal W, Ottinger J, Jones AM, Edwards BH, Goepfert P, Betts MR, Koup RA, Buchbinder S, McElrath MJ, Tartaglia J, Weinhold KJ. Absence of immunodominant anti-Gag p17 (SL9) responses among Gag CTL-positive, HIV-uninfected vaccine recipients expressing the HLA-A*0201 allele. Journal of Immunology (Baltimore, Md. : 1950). 173: 2126-33. PMID 15265949 DOI: 10.4049/jimmunol.173.3.2126  0.44
2004 Betts MR, Price DA, Brenchley JM, Loré K, Guenaga FJ, Smed-Sorensen A, Ambrozak DR, Migueles SA, Connors M, Roederer M, Douek DC, Koup RA. The functional profile of primary human antiviral CD8+ T cell effector activity is dictated by cognate peptide concentration. Journal of Immunology (Baltimore, Md. : 1950). 172: 6407-17. PMID 15128832  0.44
2004 Wolint P, Betts MR, Koup RA, Oxenius A. Immediate cytotoxicity but not degranulation distinguishes effector and memory subsets of CD8+ T cells. The Journal of Experimental Medicine. 199: 925-36. PMID 15051762 DOI: 10.1084/jem.20031799  0.44
2004 Roederer M, Brenchley JM, Betts MR, De Rosa SC. Flow cytometric analysis of vaccine responses: how many colors are enough? Clinical Immunology (Orlando, Fla.). 110: 199-205. PMID 15047198 DOI: 10.1016/j.clim.2003.11.015  0.44
2003 Betts MR, Brenchley JM, Price DA, De Rosa SC, Douek DC, Roederer M, Koup RA. Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation. Journal of Immunological Methods. 281: 65-78. PMID 14580882 DOI: 10.1016/S0022-1759(03)00265-5  0.44
2003 Loré K, Betts MR, Brenchley JM, Kuruppu J, Khojasteh S, Perfetto S, Roederer M, Seder RA, Koup RA. Toll-like receptor ligands modulate dendritic cells to augment cytomegalovirus- and HIV-1-specific T cell responses. Journal of Immunology (Baltimore, Md. : 1950). 171: 4320-8. PMID 14530357  0.44
2003 Rubio V, Stuge TB, Singh N, Betts MR, Weber JS, Roederer M, Lee PP. Ex vivo identification, isolation and analysis of tumor-cytolytic T cells. Nature Medicine. 9: 1377-82. PMID 14528297 DOI: 10.1038/nm942  0.44
2003 Tritel M, Stoddard AM, Flynn BJ, Darrah PA, Wu CY, Wille U, Shah JA, Huang Y, Xu L, Betts MR, Nabel GJ, Seder RA. Prime-boost vaccination with HIV-1 Gag protein and cytosine phosphate guanosine oligodeoxynucleotide, followed by adenovirus, induces sustained and robust humoral and cellular immune responses. Journal of Immunology (Baltimore, Md. : 1950). 171: 2538-47. PMID 12928404  0.44
2003 Brenchley JM, Karandikar NJ, Betts MR, Ambrozak DR, Hill BJ, Crotty LE, Casazza JP, Kuruppu J, Migueles SA, Connors M, Roederer M, Douek DC, Koup RA. Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells. Blood. 101: 2711-20. PMID 12433688 DOI: 10.1182/blood-2002-07-2103  0.44
2002 Brenchley JM, Douek DC, Ambrozak DR, Chatterji M, Betts MR, Davis LS, Koup RA. Expansion of activated human naïve T-cells precedes effector function. Clinical and Experimental Immunology. 130: 432-40. PMID 12452833  0.44
2002 Betts MR, Yusim K, Koup RA. Optimal antigens for HIV vaccines based on CD8+ T response, protein length, and sequence variability. Dna and Cell Biology. 21: 665-70. PMID 12396609 DOI: 10.1089/104454902760330200  0.44
2002 Douek DC, Brenchley JM, Betts MR, Ambrozak DR, Hill BJ, Okamoto Y, Casazza JP, Kuruppu J, Kunstman K, Wolinsky S, Grossman Z, Dybul M, Oxenius A, Price DA, Connors M, et al. HIV preferentially infects HIV-specific CD4+ T cells. Nature. 417: 95-8. PMID 11986671 DOI: 10.1038/417095a  0.44
2002 Douek DC, Betts MR, Brenchley JM, Hill BJ, Ambrozak DR, Ngai KL, Karandikar NJ, Casazza JP, Koup RA. A novel approach to the analysis of specificity, clonality, and frequency of HIV-specific T cell responses reveals a potential mechanism for control of viral escape. Journal of Immunology (Baltimore, Md. : 1950). 168: 3099-104. PMID 11884484  0.44
2001 Douek DC, Betts MR, Hill BJ, Little SJ, Lempicki R, Metcalf JA, Casazza J, Yoder C, Adelsberger JW, Stevens RA, Baseler MW, Keiser P, Richman DD, Davey RT, Koup RA. Evidence for increased T cell turnover and decreased thymic output in HIV infection Journal of Immunology. 167: 6663-6668. PMID 11714838 DOI: 10.4049/jimmunol.167.11.6663  0.44
2001 Betts MR, Ambrozak DR, Douek DC, Bonhoeffer S, Brenchley JM, Casazza JP, Koup RA, Picker LJ. Analysis of total human immunodeficiency virus (HIV)-specific CD4+ and CD8+ T-cell responses: Relationship to viral load in untreated HIV infection Journal of Virology. 75: 11983-11991. PMID 11711588 DOI: 10.1128/JVI.75.24.11983-11991.2001  0.44
2001 Betts MR, Casazza JP, Koup RA. Monitoring HIV-specific CD8+ T cell responses by intracellular cytokine production Immunology Letters. 79: 117-125. PMID 11595298 DOI: 10.1016/S0165-2478(01)00273-5  0.44
2001 Casazza JP, Betts MR, Picker LJ, Koup RA. Decay kinetics of human immunodeficiency virus-specific CD8+ T cells in peripheral blood after initiation of highly active antiretroviral therapy Journal of Virology. 75: 6508-6516. PMID 11413318 DOI: 10.1128/JVI.75.14.6508-6516.2001  0.44
2001 Coull JJ, Turner D, Melby T, Betts MR, Lanier R, Margolis DM. A pilot study of the use of mycophenolate mofetil as a component of therapy for multidrug-resistant HIV-1 infection. Journal of Acquired Immune Deficiency Syndromes (1999). 26: 423-34. PMID 11391161  0.44
2001 Weinberg K, Blazar BR, Wagner JE, Agura E, Hill BJ, Smogorzewska M, Koup RA, Betts MR, Collins RH, Douek DC. Factors affecting thymic function after allogeneic hematopoietic stem cell transplantation Blood. 97: 1458-1466. PMID 11222394 DOI: 10.1182/blood.V97.5.1458  0.44
2000 Goulder PJR, Tang Y, Brander C, Betts MR, Altfeld M, Annamalai K, Trocha A, He S, Rosenberg ES, Ogg G, O'Callaghan CA, Kalams SA, McKinney RE, Mayer K, Koup RA, et al. Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children Journal of Experimental Medicine. 192: 1819-1831. PMID 11120778 DOI: 10.1084/jem.192.12.1819  0.44
2000 Betts MR, Casazza JP, Patterson BA, Waldrop S, Trigona W, Fu TM, Kern F, Picker LJ, Koup RA. Putative immunodominant human immunodeficiency virus-specific CD8(+) T-cell responses cannot be predicted by major histocompatibility complex class I haplotype. Journal of Virology. 74: 9144-51. PMID 10982361 DOI: 10.1128/JVI.74.19.9144-9151.2000  0.44
2000 Douek DC, Vescio RA, Betts MR, Brenchley JM, Hill BJ, Zhang L, Berenson JR, Collins RH, Koup RA. Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution Lancet. 355: 1875-1881. PMID 10866444  0.44
2000 Davis NL, Caley IJ, Brown KW, Betts MR, Irlbeck DM, McGrath KM, Connell MJ, Montefiori DC, Frelinger JA, Swanstrom R, Johnson PR, Johnston RE. Vaccination of macaques against pathogenic simian immunodeficiency virus with Venezuelan equine encephalitis virus replicon particles. Journal of Virology. 74: 371-8. PMID 10590126  0.44
1999 Betts MR, Krowka JF, Kepler TB, Davidian M, Christopherson C, Kwok S, Louie L, Eron J, Sheppard H, Frelinger JA. Human immunodeficiency virus type 1-specific cytotoxic T lymphocyte activity is inversely correlated with HIV type 1 viral load in HIV type 1- infected long-term survivors Aids Research and Human Retroviruses. 15: 1219-1228. PMID 10480635 DOI: 10.1089/088922299310313  0.44
1999 Caley IJ, Betts MR, Davis NL, Swanstrom R, Frelinger JA, Johnston RE. Venezuelan equine encephalitis virus vectors expressing HIV-1 proteins: vector design strategies for improved vaccine efficacy. Vaccine. 17: 3124-35. PMID 10462249 DOI: 10.1016/S0264-410X(99)00142-5  0.44
1997 Betts MR, Krowka J, Santamaria C, Balsamo K, Gao F, Mulundu G, Luo C, N'Gandu N, Sheppard H, Hahn BH, Allen S, Frelinger JA. Cross-clade human immunodeficiency virus (HIV)-specific cytotoxic T- lymphocyte responses in HIV-infected Zambians Journal of Virology. 71: 8908-8911. PMID 9343257  0.44
1997 Caley IJ, Betts MR, Irlbeck DM, Davis NL, Swanstrom R, Frelinger JA, Johnston RE. Humoral, mucosal, and cellular immunity in response to a human immunodeficiency virus type 1 immunogen expressed by a Venezuelan equine encephalitis virus vaccine vector. Journal of Virology. 71: 3031-8. PMID 9060663  0.44
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