Warren S. Pear - Publications

Cell and Molecular Biology University of Pennsylvania, Philadelphia, PA, United States 
Molecular Biology, Immunology, Human Development

132 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Petrovic J, Zhou Y, Fasolino M, Goldman N, Schwartz GW, Mumbach MR, Nguyen SC, Rome KS, Sela Y, Zapataro Z, Blacklow SC, Kruhlak MJ, Shi J, Aster JC, Joyce EF, ... ... Pear WS, et al. Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques. Molecular Cell. PMID 30745086 DOI: 10.1016/j.molcel.2019.01.006  0.32
2017 Pajcini KV, Xu L, Shao L, Petrovic J, Palasiewicz K, Ohtani Y, Bailis W, Lee C, Wertheim GB, Mani R, Musuthamy N, Li Y, Meijerink JPP, Blacklow SC, Faryabi RB, ... ... Pear WS, et al. MAFB enhances oncogenic Notch signaling in T cell acute lymphoblastic leukemia. Science Signaling. 10. PMID 29138297 DOI: 10.1126/scisignal.aam6846  0.32
2017 Ryan RJH, Petrovic J, Rausch DM, Zhou Y, Lareau CA, Kluk MJ, Christie AL, Lee WY, Tarjan DR, Guo B, Donohue LKH, Gillespie SM, Nardi V, Hochberg EP, Blacklow SC, ... ... Pear WS, et al. A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas. Cell Reports. 21: 784-797. PMID 29045844 DOI: 10.1016/j.celrep.2017.09.066  0.32
2017 Choi SH, Severson E, Pear WS, Liu XS, Aster JC, Blacklow SC. The common oncogenomic program of NOTCH1 and NOTCH3 signaling in T-cell acute lymphoblastic leukemia. Plos One. 12: e0185762. PMID 29023469 DOI: 10.1371/journal.pone.0185762  0.32
2017 Severson E, Arnett KL, Wang H, Zang C, Taing L, Liu H, Pear WS, Shirley Liu X, Blacklow SC, Aster JC. Genome-wide identification and characterization of Notch transcription complex-binding sequence-paired sites in leukemia cells. Science Signaling. 10. PMID 28465412 DOI: 10.1126/scisignal.aag1598  0.32
2016 Kobayashi M, Nabinger S, Bai Y, Yoshimoto M, Gao R, Chen S, Yao C, Dong Y, Zhang L, Rodriguez S, Yashiro-Ohtani Y, Pear WS, Carlesso N, Yoder MC, Kapur R, et al. Protein Tyrosine Phosphatase PRL2 Mediates Notch and Kit Signals In Early T Cell Progenitors. Stem Cells (Dayton, Ohio). PMID 28009085 DOI: 10.1002/stem.2559  0.32
2016 Aster JC, Pear WS, Blacklow SC. The Varied Roles of Notch in Cancer. Annual Review of Pathology. PMID 27959635 DOI: 10.1146/annurev-pathol-052016-100127  0.32
2016 Stein SJ, Mack EA, Rome KS, Pajcini KV, Ohtani T, Xu L, Li Y, Meijerink JP, Faryabi RB, Pear WS. Trib2 Suppresses Tumor Initiation in Notch-Driven T-ALL. Plos One. 11: e0155408. PMID 27191957 DOI: 10.1371/journal.pone.0155408  0.32
2016 Uljon S, Xu X, Durzynska I, Stein S, Adelmant G, Marto JA, Pear WS, Blacklow SC. Structural Basis for Substrate Selectivity of the E3 Ligase COP1. Structure (London, England : 1993). PMID 27041596 DOI: 10.1016/j.str.2016.03.002  0.32
2015 Stein SJ, Mack EA, Rome KS, Pear WS. Tribbles in normal and malignant haematopoiesis. Biochemical Society Transactions. 43: 1112-5. PMID 26517933 DOI: 10.1042/BST20150117  0.32
2015 Kiss-Toth E, Velasco G, Pear WS. Tribbles at the cross-roads…. Biochemical Society Transactions. 43: 1049-50. PMID 26517921 DOI: 10.1042/BST20150122  0.32
2015 Basu R, Whitley SK, Bhaumik S, Zindl CL, Schoeb TR, Benveniste EN, Pear WS, Hatton RD, Weaver CT. IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance. Nature Immunology. 16: 286-95. PMID 25642823 DOI: 10.1038/ni.3099  0.32
2014 Yashiro-Ohtani Y, Wang H, Zang C, Arnett KL, Bailis W, Ho Y, Knoechel B, Lanauze C, Louis L, Forsyth KS, Chen S, Chung Y, Schug J, Blobel GA, Liebhaber SA, ... ... Pear WS, et al. Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia. Proceedings of the National Academy of Sciences of the United States of America. 111: E4946-53. PMID 25369933 DOI: 10.1073/pnas.1407079111  0.32
2014 Stoeck A, Lejnine S, Truong A, Pan L, Wang H, Zang C, Yuan J, Ware C, MacLean J, Garrett-Engele PW, Kluk M, Laskey J, Haines BB, Moskaluk C, Zawel L, ... ... Pear WS, et al. Discovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma. Cancer Discovery. 4: 1154-67. PMID 25104330 DOI: 10.1158/2159-8290.CD-13-0830  0.32
2014 Bailis W, Yashiro-Ohtani Y, Pear WS. Identifying direct Notch transcriptional targets using the GSI-washout assay. Methods in Molecular Biology (Clifton, N.J.). 1187: 247-54. PMID 25053495 DOI: 10.1007/978-1-4939-1139-4_19  0.32
2014 Zhang S, Kong S, Wang B, Cheng X, Chen Y, Wu W, Wang Q, Shi J, Zhang Y, Wang S, Lu J, Lydon JP, DeMayo F, Pear WS, Han H, et al. Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms. Cell Research. 24: 925-42. PMID 24971735 DOI: 10.1038/cr.2014.82  0.32
2014 Gerhardt DM, Pajcini KV, D'altri T, Tu L, Jain R, Xu L, Chen MJ, Rentschler S, Shestova O, Wertheim GB, Tobias JW, Kluk M, Wood AW, Aster JC, Gimotty PA, ... ... Pear WS, et al. The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells. Genes & Development. 28: 576-93. PMID 24637115 DOI: 10.1101/gad.227496.113  0.32
2014 Wang H, Zang C, Taing L, Arnett KL, Wong YJ, Pear WS, Blacklow SC, Liu XS, Aster JC. NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers. Proceedings of the National Academy of Sciences of the United States of America. 111: 705-10. PMID 24374627 DOI: 10.1073/pnas.1315023111  0.32
2013 De Obaldia ME, Bell JJ, Wang X, Harly C, Yashiro-Ohtani Y, DeLong JH, Zlotoff DA, Sultana DA, Pear WS, Bhandoola A. T cell development requires constraint of the myeloid regulator C/EBP-α by the Notch target and transcriptional repressor Hes1. Nature Immunology. 14: 1277-84. PMID 24185616 DOI: 10.1038/ni.2760  0.32
2013 Bailis W, Yashiro-Ohtani Y, Fang TC, Hatton RD, Weaver CT, Artis D, Pear WS. Notch simultaneously orchestrates multiple helper T cell programs independently of cytokine signals. Immunity. 39: 148-59. PMID 23890069 DOI: 10.1016/j.immuni.2013.07.006  0.32
2013 Clarke RL, Yzaguirre AD, Yashiro-Ohtani Y, Bondue A, Blanpain C, Pear WS, Speck NA, Keller G. The expression of Sox17 identifies and regulates haemogenic endothelium. Nature Cell Biology. 15: 502-10. PMID 23604320 DOI: 10.1038/ncb2724  0.32
2013 Yang Q, Monticelli LA, Saenz SA, Chi AW, Sonnenberg GF, Tang J, De Obaldia ME, Bailis W, Bryson JL, Toscano K, Huang J, Haczku A, Pear WS, Artis D, Bhandoola A. T cell factor 1 is required for group 2 innate lymphoid cell generation. Immunity. 38: 694-704. PMID 23601684 DOI: 10.1016/j.immuni.2012.12.003  0.32
2013 Roti G, Carlton A, Ross KN, Markstein M, Pajcini K, Su AH, Perrimon N, Pear WS, Kung AL, Blacklow SC, Aster JC, Stegmaier K. Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer. Cancer Cell. 23: 390-405. PMID 23434461 DOI: 10.1016/j.ccr.2013.01.015  0.32
2013 Lin S, Shen H, Jin B, Gu Y, Chen Z, Cao C, Hu C, Keller C, Pear WS, Wu L. Brief report: Blockade of Notch signaling in muscle stem cells causes muscular dystrophic phenotype and impaired muscle regeneration. Stem Cells (Dayton, Ohio). 31: 823-8. PMID 23307608 DOI: 10.1002/stem.1319  0.32
2013 Zhang Y, Lam O, Nguyen MT, Ng G, Pear WS, Ai W, Wang IJ, Kao WW, Liu CY. Mastermind-like transcriptional co-activator-mediated Notch signaling is indispensable for maintaining conjunctival epithelial identity. Development (Cambridge, England). 140: 594-605. PMID 23293291 DOI: 10.1242/dev.082842  0.32
2013 Chiang MY, Shestova O, Xu L, Aster JC, Pear WS. Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells. Blood. 121: 905-17. PMID 23115273 DOI: 10.1182/blood-2012-03-416503  0.32
2012 Bailis W, Pear WS. Notch and PI3K: how is the road traveled? Blood. 120: 1349-50. PMID 22899471 DOI: 10.1182/blood-2012-06-435099  0.32
2011 Aster JC, Bodnar N, Xu L, Karnell F, Milholland JM, Maillard I, Histen G, Nam Y, Blacklow SC, Pear WS. Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation. Plos One. 6: e25645. PMID 22022427 DOI: 10.1371/journal.pone.0025645  0.32
2011 Liu H, Chiang MY, Pear WS. Critical roles of NOTCH1 in acute T-cell lymphoblastic leukemia. International Journal of Hematology. 94: 118-25. PMID 21814881 DOI: 10.1007/s12185-011-0899-3  0.32
2011 Chi AW, Chavez A, Xu L, Weber BN, Shestova O, Schaffer A, Wertheim G, Pear WS, Izon D, Bhandoola A. Identification of Flt3⁺CD150⁻ myeloid progenitors in adult mouse bone marrow that harbor T lymphoid developmental potential. Blood. 118: 2723-32. PMID 21791413 DOI: 10.1182/blood-2010-09-309989  0.32
2011 Wang H, Zou J, Zhao B, Johannsen E, Ashworth T, Wong H, Pear WS, Schug J, Blacklow SC, Arnett KL, Bernstein BE, Kieff E, Aster JC. Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells. Proceedings of the National Academy of Sciences of the United States of America. 108: 14908-13. PMID 21737748 DOI: 10.1073/pnas.1109023108  0.32
2011 Pajcini KV, Speck NA, Pear WS. Notch signaling in mammalian hematopoietic stem cells Leukemia. 25: 1525-1532. PMID 21647159 DOI: 10.1038/leu.2011.127  0.32
2011 Komine O, Nagaoka M, Hiraoka Y, Hoshino M, Kawaguchi Y, Pear WS, Tanaka K. RBP-J promotes the maturation of neuronal progenitors. Developmental Biology. 354: 44-54. PMID 21443869 DOI: 10.1016/j.ydbio.2011.03.020  0.32
2011 Aster JC, Blacklow SC, Pear WS. Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies. The Journal of Pathology. 223: 262-73. PMID 20967796 DOI: 10.1002/path.2789  0.32
2011 Zhang Y, Sandy AR, Wang J, Radojcic V, Shan GT, Tran IT, Friedman A, Kato K, He S, Cui S, Hexner E, Frank DM, Emerson SG, Pear WS, Maillard I. Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease. Blood. 117: 299-308. PMID 20870902 DOI: 10.1182/blood-2010-03-271940  0.32
2010 Pear WS. Hooked on Hes: a T-ALL of addiction. Immunity. 33: 645-7. PMID 21094458 DOI: 10.1016/j.immuni.2010.11.018  0.32
2010 Liu H, Chi AW, Arnett KL, Chiang MY, Xu L, Shestova O, Wang H, Li YM, Bhandoola A, Aster JC, Blacklow SC, Pear WS. Notch dimerization is required for leukemogenesis and T-cell development. Genes & Development. 24: 2395-407. PMID 20935071 DOI: 10.1101/gad.1975210  0.32
2010 Ashworth TD, Pear WS, Chiang MY, Blacklow SC, Mastio J, Xu L, Kelliher M, Kastner P, Chan S, Aster JC. Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1. Blood. 116: 5455-64. PMID 20852131 DOI: 10.1182/blood-2010-05-286328  0.32
2010 Keeshan K, Bailis W, Dedhia PH, Vega ME, Shestova O, Xu L, Toscano K, Uljon SN, Blacklow SC, Pear WS. Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding. Blood. 116: 4948-57. PMID 20805362 DOI: 10.1182/blood-2009-10-247361  0.32
2010 Ohashi S, Natsuizaka M, Yashiro-Ohtani Y, Kalman RA, Nakagawa M, Wu L, Klein-Szanto AJ, Herlyn M, Diehl JA, Katz JP, Pear WS, Seykora JT, Nakagawa H. NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional network. Gastroenterology. 139: 2113-23. PMID 20801121 DOI: 10.1053/j.gastro.2010.08.040  0.32
2010 Yashiro-Ohtani Y, Ohtani T, Pear WS. Notch regulation of early thymocyte development. Seminars in Immunology. 22: 261-9. PMID 20630772 DOI: 10.1016/j.smim.2010.04.015  0.32
2010 Liu X, Karnell JL, Yin B, Zhang R, Zhang J, Li P, Choi Y, Maltzman JS, Pear WS, Bassing CH, Turka LA. Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice. The Journal of Clinical Investigation. 120: 2497-507. PMID 20516645 DOI: 10.1172/JCI42382  0.32
2010 Khwaja SS, Liu H, Tong C, Jin F, Pear WS, van Deursen J, Bram RJ. HIV-1 Rev-binding protein accelerates cellular uptake of iron to drive Notch-induced T cell leukemogenesis in mice. The Journal of Clinical Investigation. 120: 2537-48. PMID 20516639 DOI: 10.1172/JCI41277  0.32
2010 Dedhia PH, Keeshan K, Uljon S, Xu L, Vega ME, Shestova O, Zaks-Zilberman M, Romany C, Blacklow SC, Pear WS. Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia. Blood. 116: 1321-8. PMID 20410507 DOI: 10.1182/blood-2009-07-229450  0.32
2010 Pear WS. New roles for Notch in tuberous sclerosis. The Journal of Clinical Investigation. 120: 84-7. PMID 20038806 DOI: 10.1172/JCI41897  0.32
2009 Yashiro-Ohtani Y, He Y, Ohtani T, Jones ME, Shestova O, Xu L, Fang TC, Chiang MY, Intlekofer AM, Blacklow SC, Zhuang Y, Pear WS. Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A. Genes & Development. 23: 1665-76. PMID 19605688 DOI: 10.1101/gad.1793709  0.32
2009 Pinnix CC, Lee JT, Liu ZJ, McDaid R, Balint K, Beverly LJ, Brafford PA, Xiao M, Himes B, Zabierowski SE, Yashiro-Ohtani Y, Nathanson KL, Bengston A, Pollock PM, Weeraratna AT, ... ... Pear WS, et al. Active Notch1 confers a transformed phenotype to primary human melanocytes. Cancer Research. 69: 5312-20. PMID 19549918 DOI: 10.1158/0008-5472.CAN-08-3767  0.32
2009 High FA, Jain R, Stoller JZ, Antonucci NB, Lu MM, Loomes KM, Kaestner KH, Pear WS, Epstein JA. Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development. The Journal of Clinical Investigation. 119: 1986-96. PMID 19509466 DOI: 10.1172/JCI38922  0.32
2009 Maillard I, Chen YX, Friedman A, Yang Y, Tubbs AT, Shestova O, Pear WS, Hua X. Menin regulates the function of hematopoietic stem cells and lymphoid progenitors. Blood. 113: 1661-9. PMID 19228930 DOI: 10.1182/blood-2009-01-135012  0.32
2008 Mercher T, Cornejo MG, Sears C, Kindler T, Moore SA, Maillard I, Pear WS, Aster JC, Gilliland DG. Notch signaling specifies megakaryocyte development from hematopoietic stem cells. Cell Stem Cell. 3: 314-26. PMID 18786418 DOI: 10.1016/j.stem.2008.07.010  0.32
2008 Chiang MY, Xu L, Shestova O, Histen G, L'heureux S, Romany C, Childs ME, Gimotty PA, Aster JC, Pear WS. Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia. The Journal of Clinical Investigation. 118: 3181-94. PMID 18677410 DOI: 10.1172/JCI35090  0.32
2008 Dedhia P, Kambayashi T, Pear WS. Notch2 paves the way to mast cells by Hes1 and Gata3. Proceedings of the National Academy of Sciences of the United States of America. 105: 7629-30. PMID 18515423 DOI: 10.1073/pnas.0803439105  0.32
2008 Maillard I, Koch U, Dumortier A, Shestova O, Xu L, Sai H, Pross SE, Aster JC, Bhandoola A, Radtke F, Pear WS. Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells. Cell Stem Cell. 2: 356-66. PMID 18397755 DOI: 10.1016/j.stem.2008.02.011  0.32
2008 High FA, Lu MM, Pear WS, Loomes KM, Kaestner KH, Epstein JA. Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development. Proceedings of the National Academy of Sciences of the United States of America. 105: 1955-9. PMID 18245384 DOI: 10.1073/pnas.0709663105  0.32
2008 Aster JC, Pear WS, Blacklow SC. Notch signaling in leukemia. Annual Review of Pathology. 3: 587-613. PMID 18039126 DOI: 10.1146/annurev.pathmechdis.3.121806.154300  0.32
2008 Keeshan K, Shestova O, Ussin L, Pear WS. Tribbles homolog 2 (Trib2) and HoxA9 cooperate to accelerate acute myelogenous leukemia. Blood Cells, Molecules & Diseases. 40: 119-21. PMID 17988908 DOI: 10.1016/j.bcmd.2007.06.005  0.32
2007 Proweller A, Wright AC, Horng D, Cheng L, Lu MM, Lepore JJ, Pear WS, Parmacek MS. Notch signaling in vascular smooth muscle cells is required to pattern the cerebral vasculature. Proceedings of the National Academy of Sciences of the United States of America. 104: 16275-80. PMID 17909179 DOI: 10.1073/pnas.0707950104  0.32
2007 Santos MA, Sarmento LM, Rebelo M, Doce AA, Maillard I, Dumortier A, Neves H, Radtke F, Pear WS, Parreira L, Demengeot J. Notch1 engagement by Delta-like-1 promotes differentiation of B lymphocytes to antibody-secreting cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 15454-9. PMID 17878313 DOI: 10.1073/pnas.0702891104  0.32
2007 Wu L, Maillard I, Nakamura M, Pear WS, Griffin JD. The transcriptional coactivator Maml1 is required for Notch2-mediated marginal zone B-cell development. Blood. 110: 3618-23. PMID 17699740 DOI: 10.1182/blood-2007-06-097030  0.32
2007 Wouters BJ, Jordà MA, Keeshan K, Louwers I, Erpelinck-Verschueren CA, Tielemans D, Langerak AW, He Y, Yashiro-Ohtani Y, Zhang P, Hetherington CJ, Verhaak RG, Valk PJ, Löwenberg B, Tenen DG, ... Pear WS, et al. Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1. Blood. 110: 3706-14. PMID 17671232 DOI: 10.1182/blood-2007-02-073486  0.32
2007 Fang TC, Yashiro-Ohtani Y, Del Bianco C, Knoblock DM, Blacklow SC, Pear WS. Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity. 27: 100-10. PMID 17658278 DOI: 10.1016/j.immuni.2007.04.018  0.32
2007 Spaulding C, Reschly EJ, Zagort DE, Yashiro-Ohtani Y, Beverly LJ, Capobianco A, Pear WS, Kee BL. Notch1 co-opts lymphoid enhancer factor 1 for survival of murine T-cell lymphomas. Blood. 110: 2650-8. PMID 17585052 DOI: 10.1182/blood-2007-04-084202  0.32
2007 Maillard I, Pear WS. Immunology. Keeping a tight leash on Notch. Science (New York, N.Y.). 316: 840-2. PMID 17495159 DOI: 10.1126/science.1143336  0.32
2007 Nam Y, Sliz P, Pear WS, Aster JC, Blacklow SC. Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription. Proceedings of the National Academy of Sciences of the United States of America. 104: 2103-8. PMID 17284587 DOI: 10.1073/pnas.0611092104  0.32
2007 High FA, Zhang M, Proweller A, Tu L, Parmacek MS, Pear WS, Epstein JA. An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation. The Journal of Clinical Investigation. 117: 353-63. PMID 17273555 DOI: 10.1172/JCI30070  0.32
2007 Thomas M, Calamito M, Srivastava B, Maillard I, Pear WS, Allman D. Notch activity synergizes with B-cell-receptor and CD40 signaling to enhance B-cell activation. Blood. 109: 3342-50. PMID 17179224 DOI: 10.1182/blood-2006-09-046698  0.32
2007 Roy M, Pear WS, Aster JC. The multifaceted role of Notch in cancer. Current Opinion in Genetics & Development. 17: 52-9. PMID 17178457 DOI: 10.1016/j.gde.2006.12.001  0.32
2007 Talebian L, Li Z, Guo Y, Gaudet J, Speck ME, Sugiyama D, Kaur P, Pear WS, Maillard I, Speck NA. T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFbeta dosage. Blood. 109: 11-21. PMID 16940420 DOI: 10.1182/blood-2006-05-021188  0.32
2006 Keeshan K, He Y, Wouters BJ, Shestova O, Xu L, Sai H, Rodriguez CG, Maillard I, Tobias JW, Valk P, Carroll M, Aster JC, Delwel R, Pear WS. Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia. Cancer Cell. 10: 401-11. PMID 17097562 DOI: 10.1016/j.ccr.2006.09.012  0.32
2006 Maillard I, Tu L, Sambandam A, Yashiro-Ohtani Y, Millholland J, Keeshan K, Shestova O, Xu L, Bhandoola A, Pear WS. The requirement for Notch signaling at the beta-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor. The Journal of Experimental Medicine. 203: 2239-45. PMID 16966428 DOI: 10.1084/jem.20061020  0.32
2006 Proweller A, Tu L, Lepore JJ, Cheng L, Lu MM, Seykora J, Millar SE, Pear WS, Parmacek MS. Impaired notch signaling promotes de novo squamous cell carcinoma formation. Cancer Research. 66: 7438-44. PMID 16885339 DOI: 10.1158/0008-5472.CAN-06-0793  0.32
2006 Chiang MY, Xu ML, Histen G, Shestova O, Roy M, Nam Y, Blacklow SC, Sacks DB, Pear WS, Aster JC. Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1. Molecular and Cellular Biology. 26: 6261-71. PMID 16880534 DOI: 10.1128/MCB.02478-05  0.32
2006 Weng AP, Millholland JM, Yashiro-Ohtani Y, Arcangeli ML, Lau A, Wai C, Del Bianco C, Rodriguez CG, Sai H, Tobias J, Li Y, Wolfe MS, Shachaf C, Felsher D, Blacklow SC, ... Pear WS, et al. c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes & Development. 20: 2096-109. PMID 16847353 DOI: 10.1101/gad.1450406  0.32
2006 Reschly EJ, Spaulding C, Vilimas T, Graham WV, Brumbaugh RL, Aifantis I, Pear WS, Kee BL. Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms. Blood. 107: 4115-21. PMID 16449526 DOI: 10.1182/blood-2005-09-3551  0.32
2006 Chen YX, Yan J, Keeshan K, Tubbs AT, Wang H, Silva A, Brown EJ, Hess JL, Pear WS, Hua X. The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression. Proceedings of the National Academy of Sciences of the United States of America. 103: 1018-23. PMID 16415155 DOI: 10.1073/pnas.0510347103  0.32
2006 Maillard I, Schwarz BA, Sambandam A, Fang T, Shestova O, Xu L, Bhandoola A, Pear WS. Notch-dependent T-lineage commitment occurs at extrathymic sites following bone marrow transplantation. Blood. 107: 3511-9. PMID 16397133 DOI: 10.1182/blood-2005-08-3454  0.32
2005 Pear WS, Simon MC. Lasting longer without oxygen: The influence of hypoxia on Notch signaling. Cancer Cell. 8: 435-7. PMID 16338655 DOI: 10.1016/j.ccr.2005.11.016  0.32
2005 Tu L, Fang TC, Artis D, Shestova O, Pross SE, Maillard I, Pear WS. Notch signaling is an important regulator of type 2 immunity. The Journal of Experimental Medicine. 202: 1037-42. PMID 16230473 DOI: 10.1084/jem.20050923  0.32
2005 Zweidler-McKay PA, He Y, Xu L, Rodriguez CG, Karnell FG, Carpenter AC, Aster JC, Allman D, Pear WS. Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies. Blood. 106: 3898-906. PMID 16118316 DOI: 10.1182/blood-2005-01-0355  0.32
2005 Sambandam A, Maillard I, Zediak VP, Xu L, Gerstein RM, Aster JC, Pear WS, Bhandoola A. Notch signaling controls the generation and differentiation of early T lineage progenitors. Nature Immunology. 6: 663-70. PMID 15951813 DOI: 10.1038/ni1216  0.32
2005 Maillard I, Fang T, Pear WS. Regulation of lymphoid development, differentiation, and function by the Notch pathway. Annual Review of Immunology. 23: 945-74. PMID 15771590 DOI: 10.1146/annurev.immunol.23.021704.115747  0.32
2005 Chiang MY, Pear WS. Cancer genetics: activated notch takes center stage in T-cell leukemogenesis. European Journal of Human Genetics : Ejhg. 13: 393-5. PMID 15702128 DOI: 10.1038/sj.ejhg.5201380  0.32
2005 Proweller A, Pear WS, Parmacek MS. Notch signaling represses myocardin-induced smooth muscle cell differentiation. The Journal of Biological Chemistry. 280: 8994-9004. PMID 15634680 DOI: 10.1074/jbc.M413316200  0.32
2004 Pear WS, Aster JC. T cell acute lymphoblastic leukemia/lymphoma: a human cancer commonly associated with aberrant NOTCH1 signaling. Current Opinion in Hematology. 11: 426-33. PMID 15548998 DOI: 10.1097/01.moh.0000143965.90813.70  0.32
2004 Sanchez-Irizarry C, Carpenter AC, Weng AP, Pear WS, Aster JC, Blacklow SC. Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats. Molecular and Cellular Biology. 24: 9265-73. PMID 15485896 DOI: 10.1128/MCB.24.21.9265-9273.2004  0.32
2004 Zweidler-McKay PA, Pear WS. Notch and T cell malignancy. Seminars in Cancer Biology. 14: 329-40. PMID 15288258 DOI: 10.1016/j.semcancer.2004.04.012  0.32
2004 Maillard I, Weng AP, Carpenter AC, Rodriguez CG, Sai H, Xu L, Allman D, Aster JC, Pear WS. Mastermind critically regulates Notch-mediated lymphoid cell fate decisions. Blood. 104: 1696-702. PMID 15187027 DOI: 10.1182/blood-2004-02-0514  0.32
2004 Eagar TN, Tang Q, Wolfe M, He Y, Pear WS, Bluestone JA. Notch 1 signaling regulates peripheral T cell activation. Immunity. 20: 407-15. PMID 15084270 DOI: 10.1016/S1074-7613(04)00081-0  0.32
2004 Feng B, Cheng S, Pear WS, Liou HC. NF-kB inhibitor blocks B cell development at two checkpoints. Medical Immunology (London, England). 3: 1. PMID 15050028 DOI: 10.1186/1476-9433-3-1  0.32
2004 Pear WS, Tu L, Stein PL. Lineage choices in the developing thymus: choosing the T and NKT pathways. Current Opinion in Immunology. 16: 167-73. PMID 15023409 DOI: 10.1016/j.coi.2004.01.011  0.32
2004 Gitler AD, Kong Y, Choi JK, Zhu Y, Pear WS, Epstein JA. Tie2-Cre-induced inactivation of a conditional mutant Nf1 allele in mouse results in a myeloproliferative disorder that models juvenile myelomonocytic leukemia. Pediatric Research. 55: 581-4. PMID 14739366 DOI: 10.1203/01.PDR.0000113462.98851.2E  0.32
2003 Maillard I, Adler SH, Pear WS. Notch and the immune system. Immunity. 19: 781-91. PMID 14670296 DOI: 10.1016/S1074-7613(03)00325-X  0.32
2003 Adler SH, Chiffoleau E, Xu L, Dalton NM, Burg JM, Wells AD, Wolfe MS, Turka LA, Pear WS. Notch signaling augments T cell responsiveness by enhancing CD25 expression. Journal of Immunology (Baltimore, Md. : 1950). 171: 2896-903. PMID 12960312  0.32
2003 Wertheim JA, Perera SA, Hammer DA, Ren R, Boettiger D, Pear WS. Localization of BCR-ABL to F-actin regulates cell adhesion but does not attenuate CML development. Blood. 102: 2220-8. PMID 12791659 DOI: 10.1182/blood-2003-01-0062  0.32
2003 Maillard I, He Y, Pear WS. From the yolk sac to the spleen: New roles for Notch in regulating hematopoiesis. Immunity. 18: 587-9. PMID 12753735 DOI: 10.1016/S1074-7613(03)00119-5  0.32
2003 Pear WS, Radtke F. Notch signaling in lymphopoiesis. Seminars in Immunology. 15: 69-79. PMID 12681943 DOI: 10.1016/S1044-5323(03)00003-4  0.32
2003 Maillard I, Pear WS. Notch and cancer: best to avoid the ups and downs. Cancer Cell. 3: 203-5. PMID 12676578 DOI: 10.1016/S1535-6108(03)00052-7  0.32
2003 He Y, Pear WS. Notch signalling in B cells. Seminars in Cell & Developmental Biology. 14: 135-42. PMID 12651097 DOI: 10.1016/S1084-9521(02)00182-9  0.32
2003 Weng AP, Nam Y, Wolfe MS, Pear WS, Griffin JD, Blacklow SC, Aster JC. Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling. Molecular and Cellular Biology. 23: 655-64. PMID 12509463 DOI: 10.1128/MCB.23.2.655-664.2003  0.32
2002 Allenspach EJ, Maillard I, Aster JC, Pear WS. Notch signaling in cancer. Cancer Biology & Therapy. 1: 466-76. PMID 12496471 DOI: 10.4161/cbt.1.5.162  0.32
2002 Wertheim JA, Miller JP, Xu L, He Y, Pear WS. The biology of chronic myelogenous leukemia:mouse models and cell adhesion. Oncogene. 21: 8612-28. PMID 12476308 DOI: 10.1038/sj.onc.1206089  0.32
2002 Allman D, Aster JC, Pear WS. Notch signaling in hematopoiesis and early lymphocyte development. Immunological Reviews. 187: 75-86. PMID 12366684 DOI: 10.1034/j.1600-065X.2002.18707.x  0.32
2002 Wertheim JA, Forsythe K, Druker BJ, Hammer D, Boettiger D, Pear WS. BCR-ABL-induced adhesion defects are tyrosine kinase-independent. Blood. 99: 4122-30. PMID 12010816 DOI: 10.1182/blood.V99.11.4122  0.32
2002 Allman D, Punt JA, Izon DJ, Aster JC, Pear WS. An invitation to T and more: notch signaling in lymphopoiesis. Cell. 109: S1-11. PMID 11983148 DOI: 10.1016/S0092-8674(02)00689-X  0.32
2002 He Y, Wertheim JA, Xu L, Miller JP, Karnell FG, Choi JK, Ren R, Pear WS. The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia-like disease by bcr/abl. Blood. 99: 2957-68. PMID 11929787 DOI: 10.1182/blood.V99.8.2957  0.32
2002 Judd BA, Myung PS, Obergfell A, Myers EE, Cheng AM, Watson SP, Pear WS, Allman D, Shattil SJ, Koretzky GA. Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling. The Journal of Experimental Medicine. 195: 705-17. PMID 11901197 DOI: 10.1084/jem.20011583  0.32
2002 Izon DJ, Punt JA, Pear WS. Deciphering the role of Notch signaling in lymphopoiesis. Current Opinion in Immunology. 14: 192-9. PMID 11869892 DOI: 10.1016/S0952-7915(02)00321-7  0.32
2002 Izon DJ, Aster JC, He Y, Weng A, Karnell FG, Patriub V, Xu L, Bakkour S, Rodriguez C, Allman D, Pear WS. Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1. Immunity. 16: 231-43. PMID 11869684 DOI: 10.1016/S1074-7613(02)00271-6  0.32
2001 Bannish G, Fuentes-Pananá EM, Cambier JC, Pear WS, Monroe JG. Ligand-independent signaling functions for the B lymphocyte antigen receptor and their role in positive selection during B lymphopoiesis Journal of Experimental Medicine. 194: 1583-1596. PMID 11733573 DOI: 10.1084/jem.194.11.1583  0.32
2001 Di Cristofano A, Niki M, Zhao M, Karnell FG, Clarkson B, Pear WS, Van Aelst L, Pandolfi PP. p62(dok), a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl). The Journal of Experimental Medicine. 194: 275-84. PMID 11489947 DOI: 10.1084/jem.194.3.275  0.32
2001 Izon D, Rudd K, DeMuth W, Pear WS, Clendenin C, Lindsley RC, Allman D. A common pathway for dendritic cell and early B cell development. Journal of Immunology (Baltimore, Md. : 1950). 167: 1387-92. PMID 11466357  0.32
2001 Allman D, Karnell FG, Punt JA, Bakkour S, Xu L, Myung P, Koretzky GA, Pui JC, Aster JC, Pear WS. Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells Journal of Experimental Medicine. 194: 99-106. PMID 11435476 DOI: 10.1084/jem.194.1.99  0.32
2001 Izon DJ, Punt JA, Xu L, Karnell FG, Allman D, Myung PS, Boerth NJ, Pui JC, Koretzky GA, Pear WS. Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength. Immunity. 14: 253-64. PMID 11290335 DOI: 10.1016/S1074-7613(01)00107-8  0.32
2001 Zhang X, Wong R, Hao SX, Pear WS, Ren R. The SH2 domain of bcr-Abl is not required to induce a murine myeloproliferative disease; however, SH2 signaling influences disease latency and phenotype. Blood. 97: 277-87. PMID 11133772 DOI: 10.1182/blood.V97.1.277  0.32
2000 Varnum-Finney B, Xu L, Brashem-Stein C, Nourigat C, Flowers D, Bakkour S, Pear WS, Bernstein ID. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling. Nature Medicine. 6: 1278-81. PMID 11062542 DOI: 10.1038/81390  0.32
2000 Judd BA, Myung PS, Leng L, Obergfell A, Pear WS, Shattil SJ, Koretzky GA. Hematopoietic reconstitution of SLP-76 corrects hemostasis and platelet signaling through alpha IIb beta 3 and collagen receptors. Proceedings of the National Academy of Sciences of the United States of America. 97: 12056-61. PMID 11050236 DOI: 10.1073/pnas.97.22.12056  0.32
2000 Aster JC, Xu L, Karnell FG, Patriub V, Pui JC, Pear WS. Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by Notch1 Molecular and Cellular Biology. 20: 7505-7515. PMID 11003647 DOI: 10.1128/MCB.20.20.7505-7515.2000  0.32
2000 Quackenbush RC, Reuther GW, Miller JP, Courtney KD, Pear WS, Pendergast AM. Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases. Blood. 95: 2913-21. PMID 10779439  0.32
2000 Pear WS. Signaling in leukemia: Which messenger to kill? Journal of Clinical Investigation. 105: 419-422. PMID 10683370  0.32
1999 Pui JC, Allman D, Xu L, DeRocco S, Karnell FG, Bakkour S, Lee JY, Kadesch T, Hardy RR, Aster JC, Pear WS. Notch1 expression in early lymphopoiesis influences B versus T lineage determination Immunity. 11: 299-308. PMID 10514008 DOI: 10.1016/S1074-7613(00)80105-3  0.32
1999 Jehn BM, Bielke W, Pear WS, Osborne BA. Cutting edge: Protective effects of Notch-1 on TCR-induced apoptosis Journal of Immunology. 162: 635-638. PMID 9916679  0.32
1998 Pear WS, Miller JP, Xu L, Pui JC, Soffer B, Quackenbush RC, Pendergast AM, Bronson R, Aster JC, Scott ML, Baltimore D. Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow. Blood. 92: 3780-92. PMID 9808572  0.32
1996 Pear WS, Aster JC, Scott ML, Hasserjian RP, Soffer B, Sklar J, Baltimore D. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles Journal of Experimental Medicine. 183: 2283-2291. PMID 8642337 DOI: 10.1084/jem.183.5.2283  0.32
1995 Gurish MF, Pear WS, Stevens RL, Scott ML, Sokol K, Ghildyal N, Webster MJ, Hu X, Frank Austen K, Baltimore D, Friend DS. Tissue-regulated differentiation and maturation of a v-abl-immortalized mast cell-committed progenitor Immunity. 3: 175-186. PMID 7648391 DOI: 10.1016/1074-7613(95)90087-X  0.32
1993 Pear WS, Nolan GP, Scott ML, Baltimore D. Production of high-titer helper-free retroviruses by transient transfection Proceedings of the National Academy of Sciences of the United States of America. 90: 8392-8396. PMID 7690960  0.32
1991 Axelson H, Pear WS, Panda CK, Bazin H, Klein G, Sumegi J. Transcriptional deregulation of myc in IgH/myc 6;7 translocation carrying rat immunocytomas Genes Chromosomes and Cancer. 3: 142-148. PMID 1906344  0.32
1988 Bazin H, Pear WS, Sumegi J. Louvain rat immunocytomas Advances in Cancer Research. 50: 279-310. PMID 3287846  0.32
1988 Wahlström G, Pear WS, Steen ML, Szpirer J, Levan G, Klein G, Sümegi J. Localization of the rat immunoglobulin lambda light chain locus to chromosome 11 Immunogenetics. 28: 182-183. PMID 3137157 DOI: 10.1007/BF00375857  0.32
1988 Pear WS, Nelson SF, Axelson H, Wahlstrom G, Bazin H, Klein G, Sumegi J. Aberrant class switching juxtaposes c-myc with a middle repetitive element (LINE) and an IgH intron in two spontaneously arising rat immunocytomas Oncogene. 2: 499-507. PMID 3131719  0.32
1988 Pear WS, Wahlstrom G, Nelson SF, Axelson H, Szeles A, Wiener F, Bazin H, Klein G, Sumegi J. 6;7 Chromosomal translocation in spontaneously arising rat immunocytomas: Evidence for c-myc breakpoint clustering and correlation between isotypic expression and the c-myc target Molecular and Cellular Biology. 8: 441-451. PMID 3122026  0.32
1986 Pear WS, Wahlström G, Nelson SF, Ingvarsson S, Bazin H, Klein G, Sumegi J. c-myc activation in spontaneous rat immunocytomas containing a 6;7 chromosomal translocation Current Topics in Microbiology and Immunology. 132: 169-174. PMID 3792033  0.32
1986 Pear WS, Wahlström G, Szpirer J, Levan G, Klein G, Sümegi J. Localization of the rat immunoglobulin heavy chain locus to chromosome 6 Immunogenetics. 23: 393-395. PMID 3087869 DOI: 10.1007/BF00372672  0.32
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