Andrea Amalfitano - Publications

Cell and Molecular Biology Michigan State University, East Lansing, MI 
Immunology, Oncology, Virology Biology

126 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 O'Connell P, Hyslop S, Blake MK, Godbehere S, Amalfitano A, Aldhamen YA. SLAMF7 Signaling Reprograms T Cells toward Exhaustion in the Tumor Microenvironment. Journal of Immunology (Baltimore, Md. : 1950). PMID 33288545 DOI: 10.4049/jimmunol.2000300  1
2019 O'Connell P, Zheng YH, Amalfitano A, Aldhamen YA. Infection of Primary Human Monocytes with HIV-1. Bio-Protocol. 9. PMID 32002449 DOI: 10.21769/bioprotoc.3289  1
2019 O'Connell P, Amalfitano A, Aldhamen YA. SLAM Family Receptor Signaling in Viral Infections: HIV and Beyond. Vaccines. 7. PMID 31744090 DOI: 10.3390/vaccines7040184  1
2019 Rizzo MD, Crawford RB, Bach A, Sermet S, Amalfitano A, Kaminski NE. Δ9-Tetrahydrocannabinol suppresses monocyte-mediated astrocyte production of MCP-1 and IL-6 in a TLR7-stimulated human co-culture. The Journal of Pharmacology and Experimental Therapeutics. PMID 31383729 DOI: 10.1124/jpet.119.260661  0.84
2019 Rizzo MD, Crawford RB, Bach A, Sermet S, Amalfitano A, Kaminski NE. Imiquimod and interferon-alpha augment monocyte-mediated astrocyte secretion of MCP-1, IL-6 and IP-10 in a human co-culture system. Journal of Neuroimmunology. 333: 576969. PMID 31136945 DOI: 10.1016/j.jneuroim.2019.576969  0.84
2019 Pepelyayeva Y, Amalfitano A. The role of ERAP1 in autoinflammation and autoimmunity. Human Immunology. PMID 30817945 DOI: 10.1016/j.humimm.2019.02.013  0.72
2018 O'Connell P, Pepelyayeva Y, Blake MK, Hyslop S, Crawford RB, Rizzo MD, Pereira-Hicks C, Godbehere S, Dale L, Gulick P, Kaminski NE, Amalfitano A, Aldhamen YA. SLAMF7 Is a Critical Negative Regulator of IFN-α-Mediated CXCL10 Production in Chronic HIV Infection. Journal of Immunology (Baltimore, Md. : 1950). PMID 30530590 DOI: 10.4049/jimmunol.1800847  1
2018 Pepelyayeva Y, Rastall DPW, Aldhamen YA, O'Connell P, Raehtz S, Alyaqoub FS, Blake MK, Raedy AM, Angarita AM, Abbas AM, Pereira-Hicks CN, Roosa SG, McCabe L, Amalfitano A. ERAP1 deficient mice have reduced Type 1 regulatory T cells and develop skeletal and intestinal features of Ankylosing Spondylitis. Scientific Reports. 8: 12464. PMID 30127455 DOI: 10.1038/s41598-018-30159-5  1
2018 Kady NM, Liu X, Lydic TA, Syed MH, Navitskaya S, Wang Q, Hammer SS, O'Reilly S, Huang C, Seregin SS, Amalfitano A, Chiodo VA, Boye SL, Hauswirth WW, Antonetti DA, et al. ELOVL4-Mediated Production of Very Long Chain Ceramides Stabilizes Tight Junctions and Prevents Diabetes-Induced Retinal Vascular Permeability. Diabetes. PMID 29362226 DOI: 10.2337/Db17-1034  0.96
2017 Rizzo MD, Crawford RB, Henriquez JE, Aldhamen Y, Gulick P, Amalfitano A, Kaminski NE. HIV-infected cannabis users have lower circulating CD16+ monocytes and IP-10 levels compared to non-using HIV patients. Aids (London, England). PMID 29194121 DOI: 10.1097/QAD.0000000000001704  0.84
2017 Rastall DPW, Amalfitano A. Current and Future Treatments for Lysosomal Storage Disorders. Current Treatment Options in Neurology. 19: 45. PMID 29101575 DOI: 10.1007/s11940-017-0481-2  0.96
2017 Rastall DPW, Alyaquob FS, O'Connell P, Pepelyayeva Y, Peters D, Godbehere-Roosa S, Pereira-Hicks C, Aldhamen YA, Amalfitano A. Mice expressing human ERAP1 variants associated with ankylosing spondylitis have altered T-cell repertoires and NK cell functions, as well as increased in utero and perinatal mortality. International Immunology. 29: 277-289. PMID 28814066 DOI: 10.1093/intimm/dxx035  1
2017 Quiroga D, Aldhamen YA, Godbehere S, Harding L, Amalfitano A. Decreased vector gene expression from E2b-deleted Ad5 vaccines intensifies pro-inflammatory immune responses. Clinical and Vaccine Immunology : Cvi. PMID 28381403 DOI: 10.1128/CVI.00061-17  1
2016 Rastall DP, Seregin SS, Aldhamen YA, Kaiser LM, Mullins C, Liou A, Ing F, Pereria-Hicks C, Godbehere-Roosa S, Palmer D, Ng P, Amalfitano A. Long-term, high level hepatic secretion of acid α-glucosidase for Pompe disease achieved in non-human primates using helper-dependent adenovirus. Gene Therapy. PMID 27367841 DOI: 10.1038/gt.2016.53  1
2016 Aldhamen YA, Rastall DP, Chen W, Seregin SS, Pereira-Hicks C, Godbehere S, Kaminski NE, Amalfitano A. CRACC-targeting Fc-fusion protein induces activation of NK cells and DCs and improves T cell immune responses to antigenic targets. Vaccine. PMID 27151882 DOI: 10.1016/J.Vaccine.2016.04.068  1
2016 Alyaqoub FS, Aldhamen YA, Koestler BJ, Bruger EL, Seregin SS, Pereira-Hicks C, Godbehere S, Waters CM, Amalfitano A. In Vivo Synthesis of Cyclic-di-GMP Using a Recombinant Adenovirus Preferentially Improves Adaptive Immune Responses against Extracellular Antigens. Journal of Immunology (Baltimore, Md. : 1950). PMID 26792800 DOI: 10.4049/Jimmunol.1501272  1
2016 Aldhamen YA, Amalfitano A. Methods to Mitigate Immune Responses to Adenoviral Vectors Adenoviral Vectors For Gene Therapy: Second Edition. 391-422. DOI: 10.1016/B978-0-12-800276-6.00016-4  1
2015 Rastall DP, Amalfitano A. Recent advances in gene therapy for lysosomal storage disorders. The Application of Clinical Genetics. 8: 157-69. PMID 26170711 DOI: 10.2147/TACG.S57682  1
2015 Quiroga D, Aldhamen YA, Appledorn DM, Godbehere S, Amalfitano A. Strengthened tumor antigen immune recognition by inclusion of a recombinant Eimeria antigen in therapeutic cancer vaccination. Cancer Immunology, Immunotherapy : Cii. 64: 479-91. PMID 25655760 DOI: 10.1007/s00262-015-1659-7  1
2015 Aldhamen YA, Pepelyayeva Y, Rastall DP, Seregin SS, Zervoudi E, Koumantou D, Aylsworth CF, Quiroga D, Godbehere S, Georgiadis D, Stratikos E, Amalfitano A. Autoimmune disease-associated variants of extracellular endoplasmic reticulum aminopeptidase 1 induce altered innate immune responses by human immune cells. Journal of Innate Immunity. 7: 275-89. PMID 25591727 DOI: 10.1159/000368899  1
2014 Koestler BJ, Seregin SS, Rastall DP, Aldhamen YA, Godbehere S, Amalfitano A, Waters CM. Stimulation of innate immunity by in vivo cyclic di-GMP synthesis using adenovirus. Clinical and Vaccine Immunology : Cvi. 21: 1550-9. PMID 25230938 DOI: 10.1128/Cvi.00471-14  1
2014 Rastall DP, Aldhamen YA, Seregin SS, Godbehere S, Amalfitano A. ERAP1 functions override the intrinsic selection of specific antigens as immunodominant peptides, thereby altering the potency of antigen-specific cytolytic and effector memory T-cell responses. International Immunology. 26: 685-95. PMID 25087231 DOI: 10.1093/intimm/dxu078  1
2014 Aldhamen YA, Seregin SS, Aylsworth CF, Godbehere S, Amalfitano A. Manipulation of EAT-2 expression promotes induction of multiple beneficial regulatory and effector functions of the human innate immune system as a novel immunomodulatory strategy. International Immunology. 26: 291-303. PMID 24374770 DOI: 10.1093/intimm/dxt061  1
2013 Zervoudi E, Saridakis E, Birtley JR, Seregin SS, Reeves E, Kokkala P, Aldhamen YA, Amalfitano A, Mavridis IM, James E, Georgiadis D, Stratikos E. Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses. Proceedings of the National Academy of Sciences of the United States of America. 110: 19890-5. PMID 24248368 DOI: 10.1073/pnas.1309781110  1
2013 Kovalenko PL, Yuan L, Sun K, Kunovska L, Seregin S, Amalfitano A, Basson MD. Regulation of epithelial differentiation in rat intestine by intraluminal delivery of an adenoviral vector or silencing RNA coding for Schlafen 3. Plos One. 8: e79745. PMID 24244554 DOI: 10.1371/Journal.Pone.0079745  1
2013 Seregin SS, Rastall DP, Evnouchidou I, Aylsworth CF, Quiroga D, Kamal RP, Godbehere-Roosa S, Blum CF, York IA, Stratikos E, Amalfitano A. Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens. Autoimmunity. 46: 497-508. PMID 24028501 DOI: 10.3109/08916934.2013.819855  1
2013 Aldhamen YA, Seregin SS, Kousa YA, Rastall DP, Appledorn DM, Godbehere S, Schutte BC, Amalfitano A. Improved cytotoxic T-lymphocyte immune responses to a tumor antigen by vaccines co-expressing the SLAM-associated adaptor EAT-2. Cancer Gene Therapy. 20: 564-75. PMID 23949283 DOI: 10.1038/cgt.2013.53  1
2013 Aldhamen YA, Seregin SS, Rastall DP, Aylsworth CF, Pepelyayeva Y, Busuito CJ, Godbehere-Roosa S, Kim S, Amalfitano A. Endoplasmic reticulum aminopeptidase-1 functions regulate key aspects of the innate immune response. Plos One. 8: e69539. PMID 23894499 DOI: 10.1371/journal.pone.0069539  1
2013 Aylsworth CF, Aldhamen YA, Seregin SS, Godbehere S, Amalfitano A. Activation of human natural killer cells by the novel innate immune modulator recombinant Eimeria antigen. Human Immunology. 74: 916-26. PMID 23639554 DOI: 10.1016/j.humimm.2013.04.035  1
2013 Morse MA, Chaudhry A, Gabitzsch ES, Hobeika AC, Osada T, Clay TM, Amalfitano A, Burnett BK, Devi GR, Hsu DS, Xu Y, Balcaitis S, Dua R, Nguyen S, Balint JP, et al. Novel adenoviral vector induces T-cell responses despite anti-adenoviral neutralizing antibodies in colorectal cancer patients. Cancer Immunology, Immunotherapy : Cii. 62: 1293-301. PMID 23624851 DOI: 10.1007/s00262-013-1400-3  1
2012 Evnouchidou I, Birtley J, Seregin S, Papakyriakou A, Zervoudi E, Samiotaki M, Panayotou G, Giastas P, Petrakis O, Georgiadis D, Amalfitano A, Saridakis E, Mavridis IM, Stratikos E. A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing. Journal of Immunology (Baltimore, Md. : 1950). 189: 2383-92. PMID 22837489 DOI: 10.4049/jimmunol.1200918  1
2012 Aldhamen YA, Seregin SS, Schuldt NJ, Rastall DP, Liu CJ, Godbehere S, Amalfitano A. Vaccines expressing the innate immune modulator EAT-2 elicit potent effector memory T lymphocyte responses despite pre-existing vaccine immunity. Journal of Immunology (Baltimore, Md. : 1950). 189: 1349-59. PMID 22745373 DOI: 10.4049/jimmunol.1200736  1
2012 Schuldt NJ, Aldhamen YA, Godbehere-Roosa S, Seregin SS, Kousa YA, Amalfitano A. Immunogenicity when utilizing adenovirus serotype 4 and 5 vaccines expressing circumsporozoite protein in naïve and adenovirus (Ad5) immune mice. Malaria Journal. 11: 209. PMID 22720732 DOI: 10.1186/1475-2875-11-209  1
2012 Schuldt NJ, Amalfitano A. Malaria vaccines: focus on adenovirus based vectors. Vaccine. 30: 5191-8. PMID 22683663 DOI: 10.1016/j.vaccine.2012.05.048  1
2012 Banugaria SG, Patel TT, Mackey J, Das S, Amalfitano A, Rosenberg AS, Charrow J, Chen YT, Kishnani PS. Persistence of high sustained antibodies to enzyme replacement therapy despite extensive immunomodulatory therapy in an infant with Pompe disease: need for agents to target antibody-secreting plasma cells. Molecular Genetics and Metabolism. 105: 677-80. PMID 22365055 DOI: 10.1016/j.ymgme.2012.01.019  1
2012 Seregin SS, Aldhamen YA, Rastall DP, Godbehere S, Amalfitano A. Adenovirus-based vaccination against Clostridium difficile toxin A allows for rapid humoral immunity and complete protection from toxin A lethal challenge in mice. Vaccine. 30: 1492-501. PMID 22200503 DOI: 10.1016/j.vaccine.2011.12.064  1
2012 Amalfitano A, Kishnani PS, Chen YT. Response to Reuser Genetics in Medicine. 14: 827-828. DOI: 10.1038/gim.2012.81  1
2011 Aldhamen YA, Seregin SS, Amalfitano A. Immune recognition of gene transfer vectors: focus on adenovirus as a paradigm. Frontiers in Immunology. 2: 40. PMID 22566830 DOI: 10.3389/fimmu.2011.00040  1
2011 Schuldt NJ, Aldhamen YA, Appledorn DM, Seregin SS, Kousa Y, Godbehere S, Amalfitano A. Vaccine platforms combining circumsporozoite protein and potent immune modulators, rEA or EAT-2, paradoxically result in opposing immune responses. Plos One. 6: e24147. PMID 21912619 DOI: 10.1371/journal.pone.0024147  1
2011 Seregin SS, Amalfitano A. Gene therapy for lysosomal storage diseases: progress, challenges and future prospects. Current Pharmaceutical Design. 17: 2558-74. PMID 21774776 DOI: 10.2174/138161211797247578  1
2011 Seregin SS, Aldhamen YA, Appledorn DM, Aylsworth CF, Godbehere S, Liu CJ, Quiroga D, Amalfitano A. TRIF is a critical negative regulator of TLR agonist mediated activation of dendritic cells in vivo. Plos One. 6: e22064. PMID 21760953 DOI: 10.1371/journal.pone.0022064  1
2011 Seregin SS, Aldhamen YA, Appledorn DM, Zehnder J, Voss T, Godbehere S, Amalfitano A. Use of DAF-displaying adenovirus vectors reduces induction of transgene- and vector-specific adaptive immune responses in mice. Human Gene Therapy. 22: 1083-94. PMID 21388344 DOI: 10.1089/hum.2010.218  1
2011 Evnouchidou I, Kamal RP, Seregin SS, Goto Y, Tsujimoto M, Hattori A, Voulgari PV, Drosos AA, Amalfitano A, York IA, Stratikos E. Cutting Edge: Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzyme. Journal of Immunology (Baltimore, Md. : 1950). 186: 1909-13. PMID 21242517 DOI: 10.4049/jimmunol.1003337  1
2011 Aldhamen YA, Appledorn DM, Seregin SS, Liu CJ, Schuldt NJ, Godbehere S, Amalfitano A. Expression of the SLAM family of receptors adapter EAT-2 as a novel strategy for enhancing beneficial immune responses to vaccine antigens. Journal of Immunology (Baltimore, Md. : 1950). 186: 722-32. PMID 21149608 DOI: 10.4049/jimmunol.1002105  1
2011 Appledorn DM, Aldhamen YA, Godbehere S, Seregin SS, Amalfitano A. Sublingual administration of an adenovirus serotype 5 (Ad5)-based vaccine confirms Toll-like receptor agonist activity in the oral cavity and elicits improved mucosal and systemic cell-mediated responses against HIV antigens despite preexisting Ad5 immunity. Clinical and Vaccine Immunology : Cvi. 18: 150-60. PMID 21084461 DOI: 10.1128/CVI.00341-10  1
2011 Patial S, Shahi S, Saini Y, Lee T, Packiriswamy N, Appledorn DM, Lapres JJ, Amalfitano A, Parameswaran N. G-protein coupled receptor kinase 5 mediates lipopolysaccharide-induced NFκB activation in primary macrophages and modulates inflammation in vivo in mice. Journal of Cellular Physiology. 226: 1323-33. PMID 20945396 DOI: 10.1002/Jcp.22460  1
2011 Patial S, Saini Y, Parvataneni S, Appledorn DM, Dorn GW, Lapres JJ, Amalfitano A, Senagore P, Parameswaran N. Myeloid-specific GPCR kinase-2 negatively regulates NF-κB1p105-ERK pathway and limits endotoxemic shock in mice. Journal of Cellular Physiology. 226: 627-37. PMID 20717897 DOI: 10.1002/Jcp.22384  1
2010 Seregin SS, Amalfitano A. Improving adenovirus based gene transfer: strategies to accomplish immune evasion. Viruses. 2: 2013-36. PMID 21994718 DOI: 10.3390/v2092013  1
2010 Porter KJ, Gonipeta B, Parvataneni S, Appledorn DM, Patial S, Sharma D, Gangur V, Amalfitano A, Parameswaran N. Regulation of lipopolysaccharide-induced inflammatory response and endotoxemia by beta-arrestins. Journal of Cellular Physiology. 225: 406-16. PMID 20589830 DOI: 10.1002/jcp.22289  1
2010 Seregin SS, Aldhamen YA, Appledorn DM, Hartman ZC, Schuldt NJ, Scott J, Godbehere S, Jiang H, Frank MM, Amalfitano A. Adenovirus capsid-display of the retro-oriented human complement inhibitor DAF reduces Ad vector-triggered immune responses in vitro and in vivo. Blood. 116: 1669-77. PMID 20511542 DOI: 10.1182/blood-2010-03-276949  1
2010 Seregin SS, Hartman ZC, Appledorn DM, Godbehere S, Jiang H, Frank MM, Amalfitano A. Novel adenovirus vectors 'capsid-displaying' a human complement inhibitor. Journal of Innate Immunity. 2: 353-9. PMID 20375551 DOI: 10.1159/000284368  1
2010 Appledorn DM, Aldhamen YA, Depas W, Seregin SS, Liu CJ, Schuldt N, Quach D, Quiroga D, Godbehere S, Zlatkin I, Kim S, McCormick JJ, Amalfitano A. A new adenovirus based vaccine vector expressing an Eimeria tenella derived TLR agonist improves cellular immune responses to an antigenic target. Plos One. 5: e9579. PMID 20221448 DOI: 10.1371/journal.pone.0009579  1
2010 Hartman ZC, Wei J, Osada T, Glass O, Lei G, Yang XY, Peplinski S, Kim DW, Xia W, Spector N, Marks J, Barry W, Hobeika A, Devi G, Amalfitano A, et al. An adenoviral vaccine encoding full-length inactivated human Her2 exhibits potent immunogenicty and enhanced therapeutic efficacy without oncogenicity. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 1466-77. PMID 20179231 DOI: 10.1158/1078-0432.CCR-09-2549  1
2010 Seregin SS, Appledorn DM, Patial S, Bujold M, Nance W, Godbehere S, Parameswaran N, Amalfitano A. beta-Arrestins modulate Adenovirus-vector-induced innate immune responses: differential regulation by beta-arrestin-1 and beta-arrestin-2. Virus Research. 147: 123-34. PMID 19896992 DOI: 10.1016/j.virusres.2009.10.023  1
2010 Morse MA, Wei J, Hartman Z, Xia W, Ren XR, Lei G, Barry WT, Osada T, Hobeika AC, Peplinski S, Jiang H, Devi GR, Chen W, Spector N, Amalfitano A, et al. Synergism from combined immunologic and pharmacologic inhibition of HER2 in vivo. International Journal of Cancer. 126: 2893-903. PMID 19856307 DOI: 10.1002/ijc.24995  1
2009 Appledorn DM, Patial S, Godbehere S, Parameswaran N, Amalfitano A. TRIF, and TRIF-interacting TLRs differentially modulate several adenovirus vector-induced immune responses. Journal of Innate Immunity. 1: 376-88. PMID 20375595 DOI: 10.1159/000207194  1
2009 Seregin SS, Amalfitano A. Overcoming pre-existing adenovirus immunity by genetic engineering of adenovirus-based vectors. Expert Opinion On Biological Therapy. 9: 1521-31. PMID 19780714 DOI: 10.1517/14712590903307388  1
2009 Gabitzsch ES, Xu Y, Yoshida LH, Balint J, Amalfitano A, Jones FR. Novel Adenovirus type 5 vaccine platform induces cellular immunity against HIV-1 Gag, Pol, Nef despite the presence of Ad5 immunity. Vaccine. 27: 6394-8. PMID 19559110 DOI: 10.1016/j.vaccine.2009.06.028  1
2009 Seregin SS, Aldhamen YA, Appledorn DM, Schuldt NJ, McBride AJ, Bujold M, Godbehere SS, Amalfitano A. CR1/2 is an important suppressor of Adenovirus-induced innate immune responses and is required for induction of neutralizing antibodies. Gene Therapy. 16: 1245-59. PMID 19554032 DOI: 10.1038/gt.2009.77  1
2009 Osada T, Woo CY, McKinney M, Yang XY, Lei G, Labreche HG, Hartman ZC, Niedzwiecki D, Chao N, Amalfitano A, Morse MA, Lyerly HK, Clay TM. Induction of Wilms' tumor protein (WT1)-specific antitumor immunity using a truncated WT1-expressing adenovirus vaccine. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 2789-96. PMID 19351755 DOI: 10.1158/1078-0432.CCR-08-2589  1
2009 Rathinam VA, Appledorn DM, Hoag KA, Amalfitano A, Mansfield LS. Campylobacter jejuni-induced activation of dendritic cells involves cooperative signaling through Toll-like receptor 4 (TLR4)-MyD88 and TLR4-TRIF axes. Infection and Immunity. 77: 2499-507. PMID 19332531 DOI: 10.1128/Iai.01562-08  1
2009 Osada T, Yang XY, Hartman ZC, Glass O, Hodges BL, Niedzwiecki D, Morse MA, Lyerly HK, Amalfitano A, Clay TM. Optimization of vaccine responses with an E1, E2b and E3-deleted Ad5 vector circumvents pre-existing anti-vector immunity. Cancer Gene Therapy. 16: 673-82. PMID 19229288 DOI: 10.1038/cgt.2009.17  1
2009 Seregin SS, Appledorn DM, McBride AJ, Schuldt NJ, Aldhamen YA, Voss T, Wei J, Bujold M, Nance W, Godbehere S, Amalfitano A. Transient pretreatment with glucocorticoid ablates innate toxicity of systemically delivered adenoviral vectors without reducing efficacy. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 685-96. PMID 19174760 DOI: 10.1038/mt.2008.297  1
2009 Gabitzsch ES, Xu Y, Yoshida LH, Balint J, Gayle RB, Amalfitano A, Jones FR. A preliminary and comparative evaluation of a novel Ad5 [E1-, E2b-] recombinant-based vaccine used to induce cell mediated immune responses. Immunology Letters. 122: 44-51. PMID 19073216 DOI: 10.1016/j.imlet.2008.11.003  1
2009 Motyl KJ, Botolin S, Irwin R, Appledorn DM, Kadakia T, Amalfitano A, Schwartz RC, McCabe LR. Bone inflammation and altered gene expression with type I diabetes early onset. Journal of Cellular Physiology. 218: 575-83. PMID 19006181 DOI: 10.1002/jcp.21626  1
2009 Gabitzsch ES, Xu Y, Yoshida LH, Balint JP, Amalfitano A, Jones FR. P19-47. Novel adenovirus type 5 vaccine platform induces cellular immunity against HIV-1 Gag, Pol, Nef despite the presence of Ad5 immunity Retrovirology. 6: P367. DOI: 10.1186/1742-4690-6-S3-P367  1
2008 Appledorn DM, Patial S, McBride A, Godbehere S, Van Rooijen N, Parameswaran N, Amalfitano A. Adenovirus vector-induced innate inflammatory mediators, MAPK signaling, as well as adaptive immune responses are dependent upon both TLR2 and TLR9 in vivo. Journal of Immunology (Baltimore, Md. : 1950). 181: 2134-44. PMID 18641352  1
2008 Appledorn DM, McBride A, Seregin S, Scott JM, Schuldt N, Kiang A, Godbehere S, Amalfitano A. Complex interactions with several arms of the complement system dictate innate and humoral immunity to adenoviral vectors. Gene Therapy. 15: 1606-17. PMID 18615115 DOI: 10.1038/gt.2008.114  1
2008 Appledorn DM, Seregin S, Amalfitano A. Adenovirus vectors for renal-targeted gene delivery. Contributions to Nephrology. 159: 47-62. PMID 18391584 DOI: 10.1159/000125581  1
2008 Appledorn DM, Kiang A, McBride A, Jiang H, Seregin S, Scott JM, Stringer R, Kousa Y, Hoban M, Frank MM, Amalfitano A. Wild-type adenoviruses from groups A-F evoke unique innate immune responses, of which HAd3 and SAd23 are partially complement dependent. Gene Therapy. 15: 885-901. PMID 18288208 DOI: 10.1038/gt.2008.18  1
2008 Hartman ZC, Appledorn DM, Serra D, Glass O, Mendelson TB, Clay TM, Amalfitano A. Replication-attenuated Human Adenoviral Type 4 vectors elicit capsid dependent enhanced innate immune responses that are partially dependent upon interactions with the complement system. Virology. 374: 453-67. PMID 18280530 DOI: 10.1016/j.virol.2008.01.017  1
2008 Hartman ZC, Appledorn DM, Amalfitano A. Adenovirus vector induced innate immune responses: impact upon efficacy and toxicity in gene therapy and vaccine applications. Virus Research. 132: 1-14. PMID 18036698 DOI: 10.1016/j.virusres.2007.10.005  1
2007 Kiang A, Amalfitano A. Progress and problems when considering gene therapy for GSD-II Acta Myologica. 26: 49-52. PMID 17915570  1
2007 Hensley SE, Amalfitano A. Toll-like receptors impact on safety and efficacy of gene transfer vectors. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1417-22. PMID 17551505 DOI: 10.1038/Sj.Mt.6300217  1
2007 Hartman ZC, Kiang A, Everett RS, Serra D, Yang XY, Clay TM, Amalfitano A. Adenovirus infection triggers a rapid, MyD88-regulated transcriptome response critical to acute-phase and adaptive immune responses in vivo. Journal of Virology. 81: 1796-812. PMID 17121790 DOI: 10.1128/JVI.01936-06  1
2007 Hartman ZC, Black EP, Amalfitano A. Adenoviral infection induces a multi-faceted innate cellular immune response that is mediated by the toll-like receptor pathway in A549 cells. Virology. 358: 357-72. PMID 17027060 DOI: 10.1016/j.virol.2006.08.041  1
2007 McColl BW, McGregor AL, Wong A, Harris JD, Amalfitano A, Magnoni S, Baker AH, Dickson G, Horsburgh K. APOE epsilon3 gene transfer attenuates brain damage after experimental stroke. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 27: 477-87. PMID 16804548 DOI: 10.1038/Sj.Jcbfm.9600361  1
2006 Xu F, Serra D, Amalfitano A. Applications of adenoviral vector-mediated gene transfer in cardiovascular research. Methods in Molecular Medicine. 129: 209-39. PMID 17085814 DOI: 10.1385/1-59745-213-0:209  1
2006 Kishnani PS, Nicolino M, Voit T, Rogers RC, Tsai AC, Waterson J, Herman GE, Amalfitano A, Thurberg BL, Richards S, Davison M, Corzo D, Chen YT. Chinese hamster ovary cell-derived recombinant human acid alpha-glucosidase in infantile-onset Pompe disease. The Journal of Pediatrics. 149: 89-97. PMID 16860134 DOI: 10.1016/j.jpeds.2006.02.035  1
2006 Li H, Li JZ, Pittman DD, Amalfitano A, Hankins GR, Helm GA. Comparison of osteogenic potentials of human rat BMP4 and BMP6 gene therapy using [E1-] and [E1-,E2b-] adenoviral vectors. International Journal of Medical Sciences. 3: 97-105. PMID 16761078  1
2006 Kiang A, Hartman ZC, Everett RS, Serra D, Jiang H, Frank MM, Amalfitano A. Multiple innate inflammatory responses induced after systemic adenovirus vector delivery depend on a functional complement system. Molecular Therapy : the Journal of the American Society of Gene Therapy. 14: 588-98. PMID 16733096 DOI: 10.1016/j.ymthe.2006.03.024  1
2006 Kiang A, Hartman ZC, Liao S, Xu F, Serra D, Palmer DJ, Ng P, Amalfitano A. Fully deleted adenovirus persistently expressing GAA accomplishes long-term skeletal muscle glycogen correction in tolerant and nontolerant GSD-II mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 13: 127-34. PMID 16169280 DOI: 10.1016/j.ymthe.2005.08.006  1
2006 Harris JD, Graham IR, Amalfitano A, Owen JS, Dickson G. Delivery of human apolipoprotein (apo) E to liver by an [E1-, E3-, polymerase-, pTP-] adenovirus vector containing a liver-specific promoter inhibits atherogenesis in immunocompetent apoE-deficient mice Gene Therapy and Molecular Biology. 10: 17-29.  1
2005 Franco LM, Sun B, Yang X, Bird A, Zhang H, Schneider A, Brown T, Young SP, Clay TM, Amalfitano A, Chen YT, Koeberl DD. Evasion of immune responses to introduced human acid alpha-glucosidase by liver-restricted expression in glycogen storage disease type II. Molecular Therapy : the Journal of the American Society of Gene Therapy. 12: 876-84. PMID 16005263 DOI: 10.1016/j.ymthe.2005.04.024  1
2005 An Y, Young SP, Kishnani PS, Millington DS, Amalfitano A, Corz D, Chen YT. Glucose tetrasaccharide as a biomarker for monitoring the therapeutic response to enzyme replacement therapy for Pompe disease. Molecular Genetics and Metabolism. 85: 247-54. PMID 15886040 DOI: 10.1016/j.ymgme.2005.03.010  1
2005 Peppel K, Zhang L, Orman ES, Hagen PO, Amalfitano A, Brian L, Freedman NJ. Activation of vascular smooth muscle cells by TNF and PDGF: overlapping and complementary signal transduction mechanisms. Cardiovascular Research. 65: 674-82. PMID 15664394 DOI: 10.1016/j.cardiores.2004.10.031  1
2005 Sun B, Zhang H, Franco LM, Young SP, Schneider A, Bird A, Amalfitano A, Chen YT, Koeberl DD. Efficacy of an adeno-associated virus 8-pseudotyped vector in glycogen storage disease type II. Molecular Therapy : the Journal of the American Society of Gene Therapy. 11: 57-65. PMID 15585406 DOI: 10.1016/j.ymthe.2004.10.004  1
2005 Xu F, Ding E, Migone F, Serra D, Schneider A, Chen YT, Amalfitano A. Glycogen storage in multiple muscles of old GSD-II mice can be rapidly cleared after a single intravenous injection with a modified adenoviral vector expressing hGAA. The Journal of Gene Medicine. 7: 171-8. PMID 15515143 DOI: 10.1002/jgm.660  1
2004 Jiang H, Wang Z, Serra D, Frank MM, Amalfitano A. Recombinant adenovirus vectors activate the alternative complement pathway, leading to the binding of human complement protein C3 independent of anti-ad antibodies. Molecular Therapy : the Journal of the American Society of Gene Therapy. 10: 1140-2. PMID 15564145 DOI: 10.1016/j.ymthe.2004.08.015  1
2004 Corey DP, García-Añoveros J, Holt JR, Kwan KY, Lin SY, Vollrath MA, Amalfitano A, Cheung EL, Derfler BH, Duggan A, Géléoc GS, Gray PA, Hoffman MP, Rehm HL, Tamasauskas D, et al. TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells. Nature. 432: 723-30. PMID 15483558 DOI: 10.1038/nature03066  1
2004 Hunley TE, Corzo D, Dudek M, Kishnani P, Amalfitano A, Chen YT, Richards SM, Phillips JA, Fogo AB, Tiller GE. Nephrotic syndrome complicating alpha-glucosidase replacement therapy for Pompe disease. Pediatrics. 114: e532-5. PMID 15466083 DOI: 10.1542/peds.2003-0988-L  1
2004 Xu F, Ding E, Liao SX, Migone F, Dai J, Schneider A, Serra D, Chen YT, Amalfitano A. Improved efficacy of gene therapy approaches for Pompe disease using a new, immune-deficient GSD-II mouse model Gene Therapy. 11: 1590-1598. PMID 15356673 DOI: 10.1038/  1
2004 Everett RS, Evans HK, Hodges BL, Ding EY, Serra DM, Amalfitano A. Strain-specific rate of shutdown of CMV enhancer activity in murine liver confirmed by use of persistent [E1-, E2b-] adenoviral vectors Virology. 325: 96-105. PMID 15231389 DOI: 10.1016/j.virol.2004.04.032  1
2004 Amalfitano A. Utilization of adenovirus vectors for multiple gene transfer applications. Methods (San Diego, Calif.). 33: 173-8. PMID 15121172 DOI: 10.1016/j.ymeth.2003.11.006  1
2003 Everett RS, Hodges BL, Ding EY, Xu F, Serra D, Amalfitano A. Liver Toxicities Typically Induced by First-Generation Adenoviral Vectors Can Be Reduced by Use of E1, E2b-Deleted Adenoviral Vectors Human Gene Therapy. 14: 1715-1726. PMID 14670123  1
2003 Amalfitano A. Use of multiply deleted adenovirus vectors to probe adenovirus vector performance and toxicities. Current Opinion in Molecular Therapeutics. 5: 362-6. PMID 14513678  1
2003 McVie-Wylie AJ, Ding EY, Lawson T, Serra D, Migone FK, Pressley D, Mizutani M, Kikuchi T, Chen YT, Amalfitano A. Multiple muscles in the AMD quail can be "cross-corrected" of pathologic glycogen accumulation after intravenous injection of an [E1-polymerase-] adenovirus vector encoding human acid-α-glucosidase Journal of Gene Medicine. 5: 399-406. PMID 12731088 DOI: 10.1002/jgm.355  1
2003 Sun B, Chen YT, Bird A, Xu F, Hou YX, Amalfitano A, Koeberl DD. Packaging of an AAV vector encoding human acid alpha-glucosidase for gene therapy in glycogen storage disease type II with a modified hybrid adenovirus-AAV vector. Molecular Therapy : the Journal of the American Society of Gene Therapy. 7: 467-77. PMID 12727109 DOI: 10.1016/S1525-0016(03)00022-4  1
2003 Dodé C, Levilliers J, Dupont JM, De Paepe A, Le Dû N, Soussi-Yanicostas N, Coimbra RS, Delmaghani S, Compain-Nouaille S, Baverel F, Pêcheux C, Le Tessier D, Cruaud C, Delpech M, Speleman F, ... ... Amalfitano A, et al. Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome. Nature Genetics. 33: 463-5. PMID 12627230 DOI: 10.1038/ng1122  1
2003 Sun BD, Chen YT, Bird A, Amalfitano A, Koeberl DD. Long-term correction of glycogen storage disease type II with a hybrid Ad-AAV vector. Molecular Therapy : the Journal of the American Society of Gene Therapy. 7: 193-201. PMID 12597907 DOI: 10.1016/S1525-0016(02)00055-2  1
2002 Amalfitano A, Parks RJ. Separating fact from fiction: assessing the potential of modified adenovirus vectors for use in human gene therapy. Current Gene Therapy. 2: 111-33. PMID 12109210  1
2002 Ding E, Hu H, Hodges BL, Migone F, Serra D, Xu F, Chen YT, Amalfitano A. Efficacy of gene therapy for a prototypical lysosomal storage disease (GSD-II) is critically dependent on vector dose, transgene promoter, and the tissues targeted for vector transduction. Molecular Therapy : the Journal of the American Society of Gene Therapy. 5: 436-46. PMID 11945071 DOI: 10.1006/mthe.2002.0563  1
2002 Dhar S, Bitting RL, Rylova SN, Jansen PJ, Lockhart E, Koeberl DD, Amalfitano A, Boustany RM. Flupirtine blocks apoptosis in batten patient lymphoblasts and in human postmitotic CLN3- and CLN2-deficient neurons. Annals of Neurology. 51: 448-66. PMID 11921051 DOI: 10.1002/ana.10143  1
2002 Rylova SN, Amalfitano A, Persaud-Sawin DA, Guo WX, Chang J, Jansen PJ, Proia AD, Boustany RM. The CLN3 gene is a novel molecular target for cancer drug discovery. Cancer Research. 62: 801-8. PMID 11830536  1
2002 Harris JD, Graham IR, Schepelmann S, Stannard AK, Roberts ML, Hodges BL, Hill V, Amalfitano A, Hassall DG, Owen JS, Dickson G. Acute regression of advanced and retardation of early aortic atheroma in immunocompetent apolipoprotein-E (apoE) deficient mice by administration of a second generation [E1(-), E3(-), polymerase(-)] adenovirus vector expressing human apoE. Human Molecular Genetics. 11: 43-58. PMID 11772998  1
2001 Gilbert R, Nalbantoglu J, Howell JM, Davies L, Fletcher S, Amalfitano A, Petrof BJ, Kamen A, Massie B, Karpati G. Dystrophin expression in muscle following gene transfer with a fully deleted ("gutted") adenovirus is markedly improved by trans-acting adenoviral gene products. Human Gene Therapy. 12: 1741-55. PMID 11560768 DOI: 10.1089/104303401750476249  1
2001 Luebke AE, Steiger JD, Hodges BL, Amalfitano A. A modified adenovirus can transfect cochlear hair cells in vivo without compromising cochlear function. Gene Therapy. 8: 789-94. PMID 11420643 DOI: 10.1038/  1
2001 Hodges BL, Evans HK, Everett RS, Ding EY, Serra D, Amalfitano A. Adenovirus vectors with the 100K gene deleted and their potential for multiple gene therapy applications Journal of Virology. 75: 5913-5920. PMID 11390592 DOI: 10.1128/JVI.75.13.5913-5920.2001  1
2001 Ding EY, Hodges BL, Hu H, McVie-Wylie AJ, Serra D, Migone FK, Pressley D, Chen YT, Amalfitano A. Long-term efficacy after [E1-, polymerase-] adenovirus-mediated transfer of human acid-α-glucosidase gene into glycogen storage disease type II knockout mice Human Gene Therapy. 12: 955-965. PMID 11387060 DOI: 10.1089/104303401750195917  1
2001 Amalfitano A, Bengur AR, Morse RP, Majure JM, Case LE, Veerling DL, Mackey J, Kishnani P, Smith W, McVie-Wylie A, Sullivan JA, Hoganson GE, Phillips JA, Schaefer GB, Charrow J, et al. Recombinant human acid alpha-glucosidase enzyme therapy for infantile glycogen storage disease type II: results of a phase I/II clinical trial. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 3: 132-8. PMID 11286229  1
2000 Ahmad A, Brinson M, Hodges BL, Chamberlain JS, Amalfitano A. Mdx mice inducibly expressing dystrophin provide insights into the potential of gene therapy for Duchenne muscular dystrophy Human Molecular Genetics. 9: 2507-2515. PMID 11030755  1
2000 Hodges BL, Serra D, Hu H, Begy CA, Chamberlain JS, Amalfitano A. Multiply deleted [E1, polymerase-, and pTP-] adenovirus vector persists despite deletion of the preterminal protein Journal of Gene Medicine. 2: 250-259. PMID 10953916  1
2000 Chen YT, Amalfitano A. Towards a molecular therapy for glycogen storage disease type II (Pompe disease) Molecular Medicine Today. 6: 245-251. PMID 10840383 DOI: 10.1016/S1357-4310(00)01694-4  1
1999 Amalfitano A. Next-generation adenoviral vectors: New and improved Gene Therapy. 6: 1643-1645. PMID 10516711 DOI: 10.1038/  1
1999 Ahmad A, Amalfitano A, Chen YT, Kishnani PS, Miller C, Kelley R. Dubowitz syndrome: A defect in the cholesterol biosynthetic pathway? [4] American Journal of Medical Genetics. 86: 503-504. PMID 10508998 DOI: 10.1002/(SICI)1096-8628(19991029)86:5<503::AID-AJMG21>3.0.CO;2-Y  1
1999 Hartigan-O'Connor D, Amalfitano A, Chamberlain JS. Improved production of gutted adenovirus in cells expressing adenovirus preterminal protein and DNA polymerase Journal of Virology. 73: 7835-7841. PMID 10438876  1
1999 Amalfitano A, Mcvie-Wylie AJ, Hu H, Dawson TL, Raben N, Plotz P, Chen YT. Systemic correction of the muscle disorder glycogen storage disease type II after hepatic targeting of a modified adenovirus vector encoding human acid-α-glucosidase Proceedings of the National Academy of Sciences of the United States of America. 96: 8861-8866. PMID 10430861 DOI: 10.1073/pnas.96.16.8861  1
1999 Hu H, Serra D, Amalfitano A. Persistence of an [E1-, polymerase-] adenovirus vector despite transduction of a neoantigen into immune-competent mice Human Gene Therapy. 10: 355-364. PMID 10048388 DOI: 10.1089/10430349950018805  1
1998 Amalfitano A, Hauser MA, Hu H, Serra D, Begy CR, Chamberlain JS. Production and characterization of improved adenovirus vectors with the E1, E2b, and E3 genes deleted Journal of Virology. 72: 926-933. PMID 9444984  1
1997 Hauser MA, Amalfitano A, Kumar-Singh R, Hauschka SD, Chamberlain JS. Improved adenoviral vectors for gene therapy of Duchenne muscular dystrophy. Neuromuscular Disorders : Nmd. 7: 277-83. PMID 9267841 DOI: 10.1016/S0960-8966(97)00052-7  1
1997 Amalfitano A, Chamberlain JS. Isolation and characterization of packaging cell lines that coexpress the adenovirus E1, DNA polymerase, and preterminal proteins: Implications for gene therapy Gene Therapy. 4: 258-263. PMID 9135740 DOI: 10.1038/Sj.Gt.3300378  1
1996 Amalfitano A, Chamberlain JS. The mdx-amplification-resistant mutation system assay, a simple and rapid polymerase chain reaction-based detection of the mdx allele Muscle and Nerve. 19: 1549-1553. PMID 8941268 DOI: 10.1002/(SICI)1097-4598(199612)19:12<1549::AID-MUS4>3.0.CO;2-A  1
1996 Amalfitano A, Begy CR, Chamberlain JS. Improved adenovirus packaging cell lines to support the growth of replication-defective gene-delivery vectors Proceedings of the National Academy of Sciences of the United States of America. 93: 3352-3356. PMID 8622940 DOI: 10.1073/pnas.93.8.3352  1
1992 Amalfitano A, Martin LG, Fluck MM. Different roles for two enhancer domains in the organ-and age-specific pattern of polyomavirus replication in the mouse Molecular and Cellular Biology. 12: 3628-3635. PMID 1321341  1
1992 Wirth JJ, Amalfitano A, Gross R, Oldstone MB, Fluck MM. Organ- and age-specific replication of polyomavirus in mice. Journal of Virology. 66: 3278-86. PMID 1316447  1
1990 Oh SY, Amalfitano A, Friderici K, Chen MC, Fluck MM. Low probability of double integration in transformation of nonpermissive cells by polyomavirus Journal of Virology. 64: 1304-1313. PMID 2154610  1
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