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Zhen-Qiang Pan - Publications

Affiliations: 
Icahn School of Medicine at Mount Sinai, New York, NY, United States 
Area:
Molecular Biology, Biochemistry
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56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Wu K, DeVita RJ, Pan ZQ. Mono-ubiquitination empowers ubiquitin chain elongation. The Journal of Biological Chemistry. 105753. PMID 38354782 DOI: 10.1016/j.jbc.2024.105753  0.377
2024 Wu K, DeVita RJ, Pan ZQ. Modulation of Cullin-RING E3 ubiquitin ligase-dependent ubiquitination by small molecule compounds. The Journal of Biological Chemistry. 105752. PMID 38354780 DOI: 10.1016/j.jbc.2024.105752  0.383
2021 Wu K, Hopkins BD, Sanchez R, DeVita RJ, Pan ZQ. Targeting Cullin-RING E3 Ubiquitin Ligase 4 by Small Molecule Modulators. Journal of Cellular Signaling. 2: 195-205. PMID 34604860 DOI: 10.33696/Signaling.2.051  0.322
2021 Wu K, Huynh KQ, Lu I, Moustakim M, Miao H, Yu C, Haeusgen MJ, Hopkins BD, Huang L, Zheng N, Sanchez R, DeVita RJ, Pan ZQ. Inhibitors of cullin-RING E3 ubiquitin ligase 4 with antitumor potential. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33602808 DOI: 10.1073/pnas.2007328118  0.324
2020 Yu Q, Hu Z, Shen Y, Jiang Y, Pan P, Hou T, Pan ZQ, Huang J, Sun Y. Gossypol inhibits cullin neddylation by targeting SAG-CUL5 and RBX1-CUL1 complexes. Neoplasia (New York, N.Y.). 22: 179-191. PMID 32145688 DOI: 10.1016/J.Neo.2020.02.003  0.418
2020 Zhang J, Zhao R, Yu C, Bryant CLN, Wu K, Liu Z, Ding Y, Zhao Y, Xue B, Pan ZQ, Li C, Huang L, Fang L. IKK-mediated Regulation of the COP9 Signalosome via Phosphorylation of CSN5. Journal of Proteome Research. PMID 31950832 DOI: 10.1021/Acs.Jproteome.9B00626  0.433
2020 Pan ZQ. Cullin-RING E3 Ubiquitin Ligase 7 in Growth Control and Cancer. Advances in Experimental Medicine and Biology. 1217: 285-296. PMID 31898234 DOI: 10.1007/978-981-15-1025-0_17  0.39
2019 Bai J, Wu K, Cao MH, Yang Y, Pan Y, Liu H, He Y, Itahana Y, Huang L, Zheng JN, Pan ZQ. SCF targets HDM2 for degradation and modulates breast cancer cell invasion and metastasis. Proceedings of the National Academy of Sciences of the United States of America. PMID 31138683 DOI: 10.1073/Pnas.1820990116  0.313
2017 Zhou H, Lu J, Liu L, Bernard D, Yang CY, Fernandez-Salas E, Chinnaswamy K, Layton S, Stuckey J, Yu Q, Zhou W, Pan Z, Sun Y, Wang S. A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation. Nature Communications. 8: 1150. PMID 29074978 DOI: 10.1038/S41467-017-01243-7  0.471
2017 Vijayakumar S, Liu G, Wen HC, Abu Y, Chong R, Nastri H, Bornstein GG, Pan ZQ, Aaronson SA. Extracellular LDLR repeats modulate Wnt signaling activity by promoting LRP6 receptor endocytosis mediated by the Itch E3 ubiquitin ligase. Genes & Cancer. 8: 613-627. PMID 28966723 DOI: 10.18632/Genesandcancer.146  0.399
2016 Zhou W, Xu J, Li H, Xu M, Chen ZJ, Wei W, Pan ZQ, Sun Y. Neddylation E2 UBE2F promotes the survival of lung cancer cells by activating CRL5 to degrade NOXA via the K11 linkage. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27591266 DOI: 10.1158/1078-0432.Ccr-16-1585  0.393
2016 Wu K, Chong RA, Yu Q, Bai J, Spratt DE, Ching K, Lee C, Miao H, Tappin I, Hurwitz J, Zheng N, Shaw GS, Sun Y, Felsenfeld DP, Sanchez R, ... ... Pan ZQ, et al. Suramin inhibits cullin-RING E3 ubiquitin ligases. Proceedings of the National Academy of Sciences of the United States of America. PMID 27001857 DOI: 10.1073/Pnas.1601089113  0.428
2015 Sun C, Li HL, Chen HR, Shi ML, Liu QH, Pan ZQ, Bai J, Zheng JN. Decreased expression of CHIP leads to increased angiogenesis via VEGF-VEGFR2 pathway and poor prognosis in human renal cell carcinoma. Scientific Reports. 5: 9774. PMID 26021863 DOI: 10.1038/Srep09774  0.303
2015 Chong RA, Wu K, Kovacev J, Pan ZQ. Generation of a proteolytic signal: E3/E2-mediated polyubiquitination of IκBα. Methods in Molecular Biology (Clifton, N.J.). 1280: 339-54. PMID 25736759 DOI: 10.1007/978-1-4939-2422-6_20  0.469
2014 Chong RA, Wu K, Spratt DE, Yang Y, Lee C, Nayak J, Xu M, Elkholi R, Tappin I, Li J, Hurwitz J, Brown BD, Chipuk JE, Chen ZJ, Sanchez R, ... ... Pan ZQ, et al. Pivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination. Proceedings of the National Academy of Sciences of the United States of America. 111: 8434-9. PMID 24912152 DOI: 10.1073/Pnas.1407849111  0.441
2014 Hartmann T, Xu X, Kronast M, Muehlich S, Meyer K, Zimmermann W, Hurwitz J, Pan ZQ, Engelhardt S, Sarikas A. Inhibition of Cullin-RING E3 ubiquitin ligase 7 by simian virus 40 large T antigen. Proceedings of the National Academy of Sciences of the United States of America. 111: 3371-6. PMID 24550499 DOI: 10.1073/Pnas.1401556111  0.681
2014 Kovacev J, Wu K, Spratt DE, Chong RA, Lee C, Nayak J, Shaw GS, Pan ZQ. A snapshot of ubiquitin chain elongation: lysine 48-tetra-ubiquitin slows down ubiquitination. The Journal of Biological Chemistry. 289: 7068-81. PMID 24464578 DOI: 10.1074/Jbc.M113.530576  0.459
2014 Spratt DE, Mercier P, Pan Z, Shaw GS. Structure and Mechanism of the E3 Ligase Rbx1 in Complex with the E2 Enzyme CDC34 Charged with Ubiquitin Biophysical Journal. 106: 47a. DOI: 10.1016/J.Bpj.2013.11.342  0.537
2012 Xu X, Keshwani M, Meyer K, Sarikas A, Taylor S, Pan ZQ. Identification of the degradation determinants of insulin receptor substrate 1 for signaling cullin-RING E3 ubiquitin ligase 7-mediated ubiquitination. The Journal of Biological Chemistry. 287: 40758-66. PMID 23045529 DOI: 10.1074/Jbc.M112.405209  0.692
2012 Kong C, Samovski D, Srikanth P, Wainszelbaum MJ, Charron AJ, Liu J, Lange JJ, Chen PI, Pan ZQ, Su X, Stahl PD. Ubiquitination and degradation of the hominoid-specific oncoprotein TBC1D3 is mediated by CUL7 E3 ligase. Plos One. 7: e46485. PMID 23029530 DOI: 10.1371/Journal.Pone.0046485  0.354
2012 Spratt DE, Wu K, Kovacev J, Pan ZQ, Shaw GS. Selective recruitment of an E2~ubiquitin complex by an E3 ubiquitin ligase. The Journal of Biological Chemistry. 287: 17374-85. PMID 22433864 DOI: 10.1074/Jbc.M112.353748  0.531
2011 Wu K, Yan H, Fang L, Wang X, Pfleger C, Jiang X, Huang L, Pan ZQ. Mono-ubiquitination drives nuclear export of the human DCN1-like protein hDCNL1. The Journal of Biological Chemistry. 286: 34060-70. PMID 21813641 DOI: 10.1074/Jbc.M111.273045  0.532
2011 Sarikas A, Hartmann T, Pan ZQ. The cullin protein family. Genome Biology. 12: 220. PMID 21554755 DOI: 10.1186/Gb-2011-12-4-220  0.518
2010 Choi YS, Wu K, Jeong K, Lee D, Jeon YH, Choi BS, Pan ZQ, Ryu KS, Cheong C. The human Cdc34 carboxyl terminus contains a non-covalent ubiquitin binding activity that contributes to SCF-dependent ubiquitination. The Journal of Biological Chemistry. 285: 17754-62. PMID 20353940 DOI: 10.1074/Jbc.M109.090621  0.538
2010 Wu K, Kovacev J, Pan ZQ. Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate. Molecular Cell. 37: 784-96. PMID 20347421 DOI: 10.1016/J.Molcel.2010.02.025  0.413
2008 Sarikas A, Xu X, Field LJ, Pan ZQ. The cullin7 E3 ubiquitin ligase: a novel player in growth control. Cell Cycle (Georgetown, Tex.). 7: 3154-61. PMID 18927510 DOI: 10.4161/Cc.7.20.6922  0.626
2008 Fang L, Wang X, Yamoah K, Chen PL, Pan ZQ, Huang L. Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. Journal of Proteome Research. 7: 4914-25. PMID 18850735 DOI: 10.1021/Pr800574C  0.631
2008 Yamoah K, Oashi T, Sarikas A, Gazdoiu S, Osman R, Pan ZQ. Autoinhibitory regulation of SCF-mediated ubiquitination by human cullin 1's C-terminal tail. Proceedings of the National Academy of Sciences of the United States of America. 105: 12230-5. PMID 18723677 DOI: 10.1073/Pnas.0806155105  0.772
2008 Xu X, Sarikas A, Dias-Santagata DC, Dolios G, Lafontant PJ, Tsai SC, Zhu W, Nakajima H, Nakajima HO, Field LJ, Wang R, Pan ZQ. The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation. Molecular Cell. 30: 403-14. PMID 18498745 DOI: 10.1016/J.Molcel.2008.03.009  0.654
2008 Jones J, Wu K, Yang Y, Guerrero C, Nillegoda N, Pan ZQ, Huang L. A targeted proteomic analysis of the ubiquitin-like modifier nedd8 and associated proteins. Journal of Proteome Research. 7: 1274-87. PMID 18247557 DOI: 10.1021/pr700749v  0.305
2007 Kumar A, Wu H, Collier-Hyams LS, Hansen JM, Li T, Yamoah K, Pan ZQ, Jones DP, Neish AS. Commensal bacteria modulate cullin-dependent signaling via generation of reactive oxygen species. The Embo Journal. 26: 4457-66. PMID 17914462 DOI: 10.1038/Sj.Emboj.7601867  0.633
2007 Umanskaya K, Radke S, Chander H, Monardo R, Xu X, Pan ZQ, O'Connell MJ, Germain D. Skp2B stimulates mammary gland development by inhibiting REA, the repressor of the estrogen receptor. Molecular and Cellular Biology. 27: 7615-22. PMID 17785450 DOI: 10.1128/Mcb.01239-07  0.592
2007 Gazdoiu S, Yamoah K, Wu K, Pan ZQ. Human Cdc34 employs distinct sites to coordinate attachment of ubiquitin to a substrate and assembly of polyubiquitin chains. Molecular and Cellular Biology. 27: 7041-52. PMID 17698585 DOI: 10.1128/Mcb.00812-07  0.772
2007 Poyurovsky MV, Priest C, Kentsis A, Borden KLB, Pan ZQ, Pavletich N, Prives C. The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity Embo Journal. 26: 90-101. PMID 17170710 DOI: 10.1038/Sj.Emboj.7601465  0.517
2007 Nakayama K, Gazdoiu S, Abraham R, Pan ZQ, Ronai Z. Hypoxia-induced assembly of prolyl hydroxylase PHD3 into complexes: implications for its activity and susceptibility for degradation by the E3 ligase Siah2. The Biochemical Journal. 401: 217-26. PMID 16958618 DOI: 10.1042/Bj20061135  0.777
2005 Yamoah K, Wu K, Pan ZQ. In vitro cleavage of Nedd8 from cullin 1 by COP9 signalosome and deneddylase 1. Methods in Enzymology. 398: 509-22. PMID 16275355 DOI: 10.1016/S0076-6879(05)98042-7  0.662
2005 Gazdoiu S, Yamoah K, Wu K, Escalante CR, Tappin I, Bermudez V, Aggarwal AK, Hurwitz J, Pan ZQ. Proximity-induced activation of human Cdc34 through heterologous dimerization. Proceedings of the National Academy of Sciences of the United States of America. 102: 15053-8. PMID 16210246 DOI: 10.1073/Pnas.0507646102  0.777
2005 Huber C, Dias-Santagata D, Glaser A, O'Sullivan J, Brauner R, Wu K, Xu X, Pearce K, Wang R, Uzielli ML, Dagoneau N, Chemaitilly W, Superti-Furga A, Dos Santos H, Mégarbané A, ... ... Pan ZQ, et al. Identification of mutations in CUL7 in 3-M syndrome. Nature Genetics. 37: 1119-24. PMID 16142236 DOI: 10.1038/Ng1628  0.575
2005 Miller F, Kentsis A, Osman R, Pan ZQ. Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL·hypoxia-inducible transcription factor-1α complex Journal of Biological Chemistry. 280: 7985-7996. PMID 15611064 DOI: 10.1074/Jbc.M413160200  0.606
2005 Reverter D, Wu K, Erdene TG, Pan ZQ, Wilkinson KD, Lima CD. Structure of a complex between Nedd8 and the Ulp/Senp protease family member Den1. Journal of Molecular Biology. 345: 141-51. PMID 15567417 DOI: 10.1016/J.Jmb.2004.10.022  0.416
2004 Pan ZQ, Kentsis A, Dias DC, Yamoah K, Wu K. Nedd8 on cullin: Building an expressway to protein destruction Oncogene. 23: 1985-1997. PMID 15021886 DOI: 10.1038/Sj.Onc.1207414  0.796
2004 Li Y, Gazdoiu S, Pan ZQ, Fuchs SY. Stability of homologue of Slimb F-box protein is regulated by availability of its substrate. The Journal of Biological Chemistry. 279: 11074-80. PMID 14707120 DOI: 10.1074/Jbc.M312301200  0.785
2003 Wu K, Yamoah K, Dolios G, Gan-Erdene T, Tan P, Chen A, Lee CG, Wei N, Wilkinson KD, Wang R, Pan ZQ. DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1. The Journal of Biological Chemistry. 278: 28882-91. PMID 12759363 DOI: 10.1074/Jbc.M302888200  0.732
2003 Gan-Erdene T, Nagamalleswari K, Yin L, Wu K, Pan ZQ, Wilkinson KD. Identification and characterization of DEN1, a deneddylase of the ULP family. The Journal of Biological Chemistry. 278: 28892-900. PMID 12759362 DOI: 10.1074/Jbc.M302890200  0.425
2002 Dias DC, Dolios G, Wang R, Pan ZQ. CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. Proceedings of the National Academy of Sciences of the United States of America. 99: 16601-6. PMID 12481031 DOI: 10.1073/Pnas.252646399  0.762
2002 Macip S, Igarashi M, Fang L, Chen A, Pan ZQ, Lee SW, Aaronson SA. Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence. The Embo Journal. 21: 2180-8. PMID 11980715 DOI: 10.1093/Emboj/21.9.2180  0.543
2002 Kim J, Kim JH, Lee SH, Kim DH, Kang HY, Bae SH, Pan ZQ, Seo YS. The novel human DNA helicase hFBH1 is an F-box protein. The Journal of Biological Chemistry. 277: 24530-7. PMID 11956208 DOI: 10.1074/Jbc.M201612200  0.401
2002 Chen A, Kleiman FE, Manley JL, Ouchi T, Pan ZQ. Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase. The Journal of Biological Chemistry. 277: 22085-92. PMID 11927591 DOI: 10.1074/Jbc.M201252200  0.659
2002 Wu K, Chen A, Tan P, Pan ZQ. The Nedd8-conjugated ROC1-CUL1 core ubiquitin ligase utilizes Nedd8 charged surface residues for efficient polyubiquitin chain assembly catalyzed by Cdc34. The Journal of Biological Chemistry. 277: 516-27. PMID 11675391 DOI: 10.1074/Jbc.M108008200  0.646
2001 Kentsis A, Dwyer EC, Perez JM, Sharma M, Chen A, Pan ZQ, Borden KLB. The RING domains of the promyelocytic leukemia protein PML and the arenaviral protein Z repress translation by directly inhibiting translation initiation factor eIF4E Journal of Molecular Biology. 312: 609-623. PMID 11575918 DOI: 10.1006/Jmbi.2001.5003  0.588
2000 Wu K, Chen A, Pan ZQ. Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerization. The Journal of Biological Chemistry. 275: 32317-24. PMID 10921923 DOI: 10.1074/Jbc.M004847200  0.69
2000 Buschmann T, Fuchs SY, Lee CG, Pan ZQ, Ronai Z. SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53. Cell. 101: 753-62. PMID 10892746 DOI: 10.1016/S0092-8674(00)80887-9  0.404
2000 Chen A, Wu K, Fuchs SY, Tan P, Gomez C, Pan ZQ. The conserved RING-H2 finger of ROC1 is required for ubiquitin ligation. The Journal of Biological Chemistry. 275: 15432-9. PMID 10748083 DOI: 10.1074/Jbc.M907300199  0.671
2000 Wu K, Fuchs SY, Chen A, Tan P, Gomez C, Ronai Z, Pan ZQ. The SCF(HOS/beta-TRCP)-ROC1 E3 ubiquitin ligase utilizes two distinct domains within CUL1 for substrate targeting and ubiquitin ligation. Molecular and Cellular Biology. 20: 1382-93. PMID 10648623 DOI: 10.1128/Mcb.20.4.1382-1393.2000  0.692
1999 Fuchs SY, Chen A, Xiong Y, Pan ZQ, Ronai Z. HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin. Oncogene. 18: 2039-46. PMID 10321728 DOI: 10.1038/Sj.Onc.1202760  0.601
1999 Tan P, Fuchs SY, Chen A, Wu K, Gomez C, Ronai Z, Pan ZQ. Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha. Molecular Cell. 3: 527-33. PMID 10230406 DOI: 10.1016/S1097-2765(00)80481-5  0.609
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