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Gary Ruvkun - Publications

Affiliations: 
Genetics Massachusetts General Hospital, Boston, MA 
Area:
miRNA, C. elegans development and lifespan
Website:
http://www.hms.harvard.edu/dms/BBS/fac/ruvkun.php
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Year Citation  Score
2020 Fischer SEJ, Ruvkun G. ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons. Proceedings of the National Academy of Sciences of the United States of America. 117: 5987-5996. PMID 32123111 DOI: 10.1073/Pnas.1919028117  0.409
2019 Armakola M, Ruvkun G. Regulation of neuronal polarity by heterochronic genes. Proceedings of the National Academy of Sciences of the United States of America. PMID 31164416 DOI: 10.1073/Pnas.1820928116  0.391
2019 Lehrbach NJ, Breen PC, Ruvkun G. Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression. Cell. 177: 737-750.e15. PMID 31002798 DOI: 10.1016/J.Cell.2019.03.035  0.323
2019 Warnhoff K, Ruvkun G. Molybdenum cofactor transfer from bacteria to nematode mediates sulfite detoxification. Nature Chemical Biology. PMID 30911177 DOI: 10.1038/S41589-019-0249-Y  0.417
2019 Kniazeva M, Ruvkun G. induces DNA damage in intestinal cells. Proceedings of the National Academy of Sciences of the United States of America. 116: 3784-3792. PMID 30808764 DOI: 10.1073/Pnas.1815656116  0.305
2018 Lin XX, Sen I, Janssens GE, Zhou X, Fonslow BR, Edgar D, Stroustrup N, Swoboda P, Yates JR, Ruvkun G, Riedel CG. DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity. Nature Communications. 9: 4400. PMID 30353013 DOI: 10.1038/S41467-018-06624-0  0.375
2018 Tillman EJ, Richardson CE, Cattie DJ, Reddy KC, Lehrbach NJ, Droste R, Ruvkun G, Kim DH. Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of . Genetics. PMID 30287474 DOI: 10.1534/Genetics.118.301450  0.583
2018 Ambros V, Ruvkun G. Recent Molecular Genetic Explorations of MicroRNAs. Genetics. 209: 651-673. PMID 29967059 DOI: 10.1534/Genetics.118.300291  0.674
2018 Newman MA, Ji F, Fischer SEJ, Anselmo A, Sadreyev RI, Ruvkun G. The surveillance of pre-mRNA splicing is an early step in RNAi of endogenous genes. Genes & Development. PMID 29739806 DOI: 10.1101/Gad.311514.118  0.457
2016 Lehrbach NJ, Ruvkun G. Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1. Elife. 5. PMID 27528192 DOI: 10.7554/Elife.17721  0.381
2016 Dowen RH, Breen PC, Tullius T, Conery AL, Ruvkun G. A microRNA program in the C. elegans hypodermis couples to intestinal mTORC2/PQM-1 signaling to modulate fat transport. Genes & Development. 30: 1515-28. PMID 27401555 DOI: 10.1101/Gad.283895.116  0.354
2016 Samuel BS, Rowedder H, Braendle C, Félix MA, Ruvkun G. Caenorhabditis elegans responses to bacteria from its natural habitats. Proceedings of the National Academy of Sciences of the United States of America. PMID 27317746 DOI: 10.1073/Pnas.1607183113  0.707
2016 Carr CE, Mojarro A, Tani J, Bhattaru SA, Zuber MT, Doebler R, Brown M, Herrington K, Talbot R, Fuller CW, Finney M, Church G, Ruvkun G. Advancing the search for extra-terrestrial genomes Ieee Aerospace Conference Proceedings. 2016. DOI: 10.1109/AERO.2016.7500859  0.365
2015 Govindan JA, Jayamani E, Zhang X, Mylonakis E, Ruvkun G. Dialogue between E. coli free radical pathways and the mitochondria of C. elegans. Proceedings of the National Academy of Sciences of the United States of America. PMID 26392561 DOI: 10.1073/Pnas.1517448112  0.327
2015 Govindan JA, Jayamani E, Zhang X, Breen P, Larkins-Ford J, Mylonakis E, Ruvkun G. Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans. Nature Cell Biology. 17: 1294-303. PMID 26322678 DOI: 10.1038/Ncb3229  0.435
2015 Phillips CM, Brown KC, Montgomery BE, Ruvkun G, Montgomery TA. piRNAs and piRNA-Dependent siRNAs Protect Conserved and Essential C. elegans Genes from Misrouting into the RNAi Pathway. Developmental Cell. 34: 457-65. PMID 26279487 DOI: 10.1016/J.Devcel.2015.07.009  0.719
2015 Sadreyev IR, Ji F, Cohen E, Ruvkun G, Tabach Y. PhyloGene server for identification and visualization of co-evolving proteins using normalized phylogenetic profiles. Nucleic Acids Research. 43: W154-9. PMID 25958392 DOI: 10.1093/Nar/Gkv452  0.332
2015 Kirienko NV, Ausubel FM, Ruvkun G. Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa. Proceedings of the National Academy of Sciences of the United States of America. 112: 1821-6. PMID 25624506 DOI: 10.1073/Pnas.1424954112  0.714
2014 Wang MC, Oakley HD, Carr CE, Sowa JN, Ruvkun G. Gene pathways that delay Caenorhabditis elegans reproductive senescence. Plos Genetics. 10: e1004752. PMID 25474471 DOI: 10.1371/Journal.Pgen.1004752  0.397
2014 Garcia SM, Tabach Y, Lourenço GF, Armakola M, Ruvkun G. Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans. Nature Structural & Molecular Biology. 21: 712-20. PMID 25038802 DOI: 10.1038/Nsmb.2858  0.456
2014 Liu Y, Samuel BS, Breen PC, Ruvkun G. Caenorhabditis elegans pathways that surveil and defend mitochondria. Nature. 508: 406-10. PMID 24695221 DOI: 10.1038/Nature13204  0.714
2014 Phillips CM, Montgomery BE, Breen PC, Roovers EF, Rim YS, Ohsumi TK, Newman MA, van Wolfswinkel JC, Ketting RF, Ruvkun G, Montgomery TA. MUT-14 and SMUT-1 DEAD box RNA helicases have overlapping roles in germline RNAi and endogenous siRNA formation. Current Biology : Cb. 24: 839-44. PMID 24684932 DOI: 10.1016/J.Cub.2014.02.060  0.681
2013 Fischer SE, Pan Q, Breen PC, Qi Y, Shi Z, Zhang C, Ruvkun G. Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans. Genes & Development. 27: 2678-95. PMID 24352423 DOI: 10.1101/Gad.233254.113  0.607
2013 Soukas AA, Carr CE, Ruvkun G. Genetic regulation of Caenorhabditis elegans lysosome related organelle function. Plos Genetics. 9: e1003908. PMID 24204312 DOI: 10.1371/Journal.Pgen.1003908  0.409
2013 Tabach Y, Golan T, Hernández-Hernández A, Messer AR, Fukuda T, Kouznetsova A, Liu JG, Lilienthal I, Levy C, Ruvkun G. Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling. Molecular Systems Biology. 9: 692. PMID 24084807 DOI: 10.1038/Msb.2013.50  0.395
2013 Shi Z, Hayes G, Ruvkun G. Dual regulation of the lin-14 target mRNA by the lin-4 miRNA. Plos One. 8: e75475. PMID 24058689 DOI: 10.1371/Journal.Pone.0075475  0.764
2013 Shore DE, Ruvkun G. A cytoprotective perspective on longevity regulation. Trends in Cell Biology. 23: 409-20. PMID 23726168 DOI: 10.1016/J.Tcb.2013.04.007  0.318
2013 Montgomery TA, Ruvkun G. MicroRNAs visit the ER. Cell. 153: 511-2. PMID 23622236 DOI: 10.1016/J.Cell.2013.04.014  0.311
2013 Riedel CG, Dowen RH, Lourenco GF, Kirienko NV, Heimbucher T, West JA, Bowman SK, Kingston RE, Dillin A, Asara JM, Ruvkun G. DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity. Nature Cell Biology. 15: 491-501. PMID 23604319 DOI: 10.1038/Ncb2720  0.69
2013 Kirienko NV, Kirienko DR, Larkins-Ford J, Wählby C, Ruvkun G, Ausubel FM. Pseudomonas aeruginosa disrupts Caenorhabditis elegans iron homeostasis, causing a hypoxic response and death. Cell Host & Microbe. 13: 406-16. PMID 23601103 DOI: 10.1016/J.Chom.2013.03.003  0.711
2013 Tabach Y, Billi AC, Hayes GD, Newman MA, Zuk O, Gabel H, Kamath R, Yacoby K, Chapman B, Garcia SM, Borowsky M, Kim JK, Ruvkun G. Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence. Nature. 493: 694-8. PMID 23364702 DOI: 10.1038/Nature11779  0.801
2013 Shi Z, Montgomery TA, Qi Y, Ruvkun G. High-throughput sequencing reveals extraordinary fluidity of miRNA, piRNA, and siRNA pathways in nematodes. Genome Research. 23: 497-508. PMID 23363624 DOI: 10.1101/Gr.149112.112  0.538
2012 Tacutu R, Shore DE, Budovsky A, de Magalhães JP, Ruvkun G, Fraifeld VE, Curran SP. Prediction of C. elegans longevity genes by human and worm longevity networks. Plos One. 7: e48282. PMID 23144747 DOI: 10.1371/Journal.Pone.0048282  0.403
2012 Zhang C, Ruvkun G. New insights into siRNA amplification and RNAi. Rna Biology. 9: 1045-9. PMID 22858672 DOI: 10.4161/Rna.21246  0.416
2012 Phillips CM, Montgomery TA, Breen PC, Ruvkun G. MUT-16 promotes formation of perinuclear mutator foci required for RNA silencing in the C. elegans germline. Genes & Development. 26: 1433-44. PMID 22713602 DOI: 10.1101/Gad.193904.112  0.681
2012 Zhang C, Montgomery TA, Fischer SE, Garcia SM, Riedel CG, Fahlgren N, Sullivan CM, Carrington JC, Ruvkun G. The Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification. Current Biology : Cb. 22: 881-90. PMID 22542102 DOI: 10.1016/J.Cub.2012.04.011  0.469
2012 Montgomery TA, Rim YS, Zhang C, Dowen RH, Phillips CM, Fischer SE, Ruvkun G. PIWI associated siRNAs and piRNAs specifically require the Caenorhabditis elegans HEN1 ortholog henn-1. Plos Genetics. 8: e1002616. PMID 22536158 DOI: 10.1371/Journal.Pgen.1002616  0.665
2012 Wählby C, Kamentsky L, Liu ZH, Riklin-Raviv T, Conery AL, O'Rourke EJ, Sokolnicki KL, Visvikis O, Ljosa V, Irazoqui JE, Golland P, Ruvkun G, Ausubel FM, Carpenter AE. An image analysis toolbox for high-throughput C. elegans assays. Nature Methods. 9: 714-6. PMID 22522656 DOI: 10.1038/Nmeth.1984  0.721
2012 Melo JA, Ruvkun G. Inactivation of conserved C. elegans genes engages pathogen- and xenobiotic-associated defenses. Cell. 149: 452-66. PMID 22500807 DOI: 10.1016/J.Cell.2012.02.050  0.704
2012 Wu X, Shi Z, Cui M, Han M, Ruvkun G. Repression of germline RNAi pathways in somatic cells by retinoblastoma pathway chromatin complexes. Plos Genetics. 8: e1002542. PMID 22412383 DOI: 10.1371/Journal.Pgen.1002542  0.515
2012 Shi Z, Ruvkun G. The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 109: 4568-73. PMID 22396595 DOI: 10.1073/Pnas.1202421109  0.507
2011 Kimura KD, Riddle DL, Ruvkun G. The C. elegans DAF-2 insulin-like receptor is abundantly expressed in the nervous system and regulated by nutritional status. Cold Spring Harbor Symposia On Quantitative Biology. 76: 113-20. PMID 22123849 DOI: 10.1101/Sqb.2011.76.010660  0.702
2011 Fischer SE, Montgomery TA, Zhang C, Fahlgren N, Breen PC, Hwang A, Sullivan CM, Carrington JC, Ruvkun G. The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications. Plos Genetics. 7: e1002369. PMID 22102828 DOI: 10.1371/Journal.Pgen.1002369  0.484
2011 Russel S, Frand AR, Ruvkun G. Regulation of the C. elegans molt by pqn-47. Developmental Biology. 360: 297-309. PMID 21989027 DOI: 10.1016/J.Ydbio.2011.09.025  0.793
2011 Hayes GD, Riedel CG, Ruvkun G. The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA. Genes & Development. 25: 2079-92. PMID 21979920 DOI: 10.1101/Gad.17153811  0.744
2011 Zhang C, Montgomery TA, Gabel HW, Fischer SE, Phillips CM, Fahlgren N, Sullivan CM, Carrington JC, Ruvkun G. mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 108: 1201-8. PMID 21245313 DOI: 10.1073/Pnas.1018695108  0.81
2011 Wang MC, Min W, Freudiger CW, Ruvkun G, Xie XS. RNAi screening for fat regulatory genes with SRS microscopy. Nature Methods. 8: 135-8. PMID 21240281 DOI: 10.1038/Nmeth.1556  0.358
2010 Wu X, Ruvkun G. Cancer. Germ cell genes and cancer. Science (New York, N.Y.). 330: 1761-2. PMID 21205660 DOI: 10.1126/Science.1200772  0.315
2010 Meli VS, Osuna B, Ruvkun G, Frand AR. MLT-10 defines a family of DUF644 and proline-rich repeat proteins involved in the molting cycle of Caenorhabditis elegans. Molecular Biology of the Cell. 21: 1648-61. PMID 20335506 DOI: 10.1091/Mbc.E08-07-0708  0.391
2010 Kabra M, Conery AL, O’Rourke EJ, Xie X, Ljosa V, Jones TR, Ausubel FM, Ruvkun G, Carpenter AE, Freund Y. Towards automated high-throughput screening of C. elegans on agar F1000research. 1. DOI: 10.7490/F1000Research.252.1  0.488
2009 Sebastiani P, Montano M, Puca A, Solovieff N, Kojima T, Wang MC, Melista E, Meltzer M, Fischer SE, Andersen S, Hartley SH, Sedgewick A, Arai Y, Bergman A, Barzilai N, ... ... Ruvkun G, et al. RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. Plos One. 4: e8210. PMID 20011587 DOI: 10.1371/Journal.Pone.0008210  0.435
2009 O'Rourke EJ, Soukas AA, Carr CE, Ruvkun G. C. elegans major fats are stored in vesicles distinct from lysosome-related organelles. Cell Metabolism. 10: 430-5. PMID 19883620 DOI: 10.1016/J.Cmet.2009.10.002  0.32
2009 Curran SP, Wu X, Riedel CG, Ruvkun G. A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature. 459: 1079-84. PMID 19506556 DOI: 10.1038/Nature08106  0.404
2009 Soukas AA, Kane EA, Carr CE, Melo JA, Ruvkun G. Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans. Genes & Development. 23: 496-511. PMID 19240135 DOI: 10.1101/Gad.1775409  0.685
2009 Sebastiani P, Montano M, Puca A, Solovieff N, Kojima T, Wang MC, Melista E, Meltzer M, Fischer SEJ, Andersen S, Hartley SH, Sedgewick A, Arai Y, Bergman A, Barzilai N, ... ... Ruvkun G, et al. Correction: RNA Editing Genes Associated with Extreme Old Age in Humans and with Lifespan in C. elegans Plos One. 4. DOI: 10.1371/Annotation/387F8074-5F80-4Bdd-Bb0B-B36D49A16Ac0  0.346
2008 Isenbarger TA, Carr CE, Johnson SS, Finney M, Church GM, Gilbert W, Zuber MT, Ruvkun G. The most conserved genome segments for life detection on Earth and other planets. Origins of Life and Evolution of the Biosphere : the Journal of the International Society For the Study of the Origin of Life. 38: 517-33. PMID 18853276 DOI: 10.1007/S11084-008-9148-Z  0.785
2008 Ruvkun G. The perfect storm of tiny RNAs. Nature Medicine. 14: 1041-5. PMID 18841145 DOI: 10.1038/Nm1008-1041  0.313
2008 Fischer SE, Butler MD, Pan Q, Ruvkun G. Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7. Nature. 455: 491-6. PMID 18784652 DOI: 10.1038/Nature07274  0.758
2008 Ruvkun G. Tiny RNA: Where do we come from? What are we? Where are we going? Trends in Plant Science. 13: 313-6. PMID 18562240 DOI: 10.1016/J.Tplants.2008.05.005  0.351
2008 Simon DJ, Madison JM, Conery AL, Thompson-Peer KL, Soskis M, Ruvkun GB, Kaplan JM, Kim JK. The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions. Cell. 133: 903-15. PMID 18510933 DOI: 10.1016/J.Cell.2008.04.035  0.435
2008 Patel DS, Fang LL, Svy DK, Ruvkun G, Li W. Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development in Caenorhabditis elegans. Development (Cambridge, England). 135: 2239-49. PMID 18495818 DOI: 10.1242/Dev.016972  0.344
2008 Gabel HW, Ruvkun G. The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi. Nature Structural & Molecular Biology. 15: 531-3. PMID 18438419 DOI: 10.1038/Nsmb.1411  0.721
2008 Pierce ML, Weston MD, Fritzsch B, Gabel HW, Ruvkun G, Soukup GA. MicroRNA-183 family conservation and ciliated neurosensory organ expression. Evolution & Development. 10: 106-13. PMID 18184361 DOI: 10.1111/J.1525-142X.2007.00217.X  0.705
2008 Isenbarger TA, Finney M, Ríos-Velázquez C, Handelsman J, Ruvkun G. Miniprimer PCR, a new lens for viewing the microbial world. Applied and Environmental Microbiology. 74: 840-9. PMID 18083877 DOI: 10.1128/Aem.01933-07  0.773
2007 Samuelson AV, Klimczak RR, Thompson DB, Carr CE, Ruvkun G. Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains. Cold Spring Harbor Symposia On Quantitative Biology. 72: 489-97. PMID 18419309 DOI: 10.1101/Sqb.2007.72.068  0.401
2007 Parry DH, Xu J, Ruvkun G. A whole-genome RNAi Screen for C. elegans miRNA pathway genes. Current Biology : Cb. 17: 2013-22. PMID 18023351 DOI: 10.1016/J.Cub.2007.10.058  0.366
2007 Samuelson AV, Carr CE, Ruvkun G. Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants. Genes & Development. 21: 2976-94. PMID 18006689 DOI: 10.1101/Gad.1588907  0.429
2007 Kim N, Dempsey CM, Kuan CJ, Zoval JV, O'Rourke E, Ruvkun G, Madou MJ, Sze JY. Gravity force transduced by the MEC-4/MEC-10 DEG/ENaC channel modulates DAF-16/FoxO activity in Caenorhabditis elegans. Genetics. 177: 835-45. PMID 17720915 DOI: 10.1534/Genetics.107.076901  0.31
2007 Curran SP, Ruvkun G. Lifespan regulation by evolutionarily conserved genes essential for viability. Plos Genetics. 3: e56. PMID 17411345 DOI: 10.1371/Journal.Pgen.0030056  0.353
2007 Ruvinsky I, Ohler U, Burge CB, Ruvkun G. Detection of broadly expressed neuronal genes in C. elegans. Developmental Biology. 302: 617-26. PMID 17046742 DOI: 10.1016/J.Ydbio.2006.09.014  0.706
2006 Hayes GD, Ruvkun G. Misexpression of the Caenorhabditis elegans miRNA let-7 is sufficient to drive developmental programs. Cold Spring Harbor Symposia On Quantitative Biology. 71: 21-7. PMID 17381276 DOI: 10.1101/Sqb.2006.71.018  0.769
2006 Hayes GD, Frand AR, Ruvkun G. The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25. Development (Cambridge, England). 133: 4631-41. PMID 17065234 DOI: 10.1242/Dev.02655  0.746
2006 Sandoval GM, Duerr JS, Hodgkin J, Rand JB, Ruvkun G. A genetic interaction between the vesicular acetylcholine transporter VAChT/UNC-17 and synaptobrevin/SNB-1 in C. elegans. Nature Neuroscience. 9: 599-601. PMID 16604067 DOI: 10.1038/Nn1685  0.76
2006 Mak HY, Nelson LS, Basson M, Johnson CD, Ruvkun G. Polygenic control of Caenorhabditis elegans fat storage. Nature Genetics. 38: 363-8. PMID 16462744 DOI: 10.1038/Ng1739  0.332
2006 Duchaine TF, Wohlschlegel JA, Kennedy S, Bei Y, Conte D, Pang K, Brownell DR, Harding S, Mitani S, Ruvkun G, Yates JR, Mello CC. Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Cell. 124: 343-54. PMID 16439208 DOI: 10.1016/J.Cell.2005.11.036  0.72
2006 Ruvkun G. Clarifications on miRNA and cancer. Science (New York, N.Y.). 311: 36-7. PMID 16400132 DOI: 10.1126/Science.311.5757.36D  0.357
2005 Frand AR, Russel S, Ruvkun G. Functional genomic analysis of C. elegans molting. Plos Biology. 3: e312. PMID 16122351 DOI: 10.1371/Journal.Pbio.0030312  0.8
2005 Wang D, Kennedy S, Conte D, Kim JK, Gabel HW, Kamath RS, Mello CC, Ruvkun G. Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants. Nature. 436: 593-7. PMID 16049496 DOI: 10.1038/Nature04010  0.807
2005 Sieburth D, Ch'ng Q, Dybbs M, Tavazoie M, Kennedy S, Wang D, Dupuy D, Rual JF, Hill DE, Vidal M, Ruvkun G, Kaplan JM. Systematic analysis of genes required for synapse structure and function. Nature. 436: 510-7. PMID 16049479 DOI: 10.1038/Nature03809  0.795
2005 Hamilton B, Dong Y, Shindo M, Liu W, Odell I, Ruvkun G, Lee SS. A systematic RNAi screen for longevity genes in C. elegans. Genes & Development. 19: 1544-55. PMID 15998808 DOI: 10.1101/Gad.1308205  0.48
2005 Efimenko E, Bubb K, Mak HY, Holzman T, Leroux MR, Ruvkun G, Thomas JH, Swoboda P. Analysis of xbx genes in C. elegans. Development (Cambridge, England). 132: 1923-34. PMID 15790967 DOI: 10.1242/Dev.01775  0.433
2005 Kim JK, Gabel HW, Kamath RS, Tewari M, Pasquinelli A, Rual JF, Kennedy S, Dybbs M, Bertin N, Kaplan JM, Vidal M, Ruvkun G. Functional genomic analysis of RNA interference in C. elegans. Science (New York, N.Y.). 308: 1164-7. PMID 15790806 DOI: 10.1126/Science.1109267  0.815
2004 Wang D, Ruvkun G. Regulation of Caenorhabditis elegans RNA interference by the daf-2 insulin stress and longevity signaling pathway. Cold Spring Harbor Symposia On Quantitative Biology. 69: 429-31. PMID 16117677 DOI: 10.1101/Sqb.2004.69.429  0.558
2004 Mansfield JH, Harfe BD, Nissen R, Obenauer J, Srineel J, Chaudhuri A, Farzan-Kashani R, Zuker M, Pasquinelli AE, Ruvkun G, Sharp PA, Tabin CJ, McManus MT. MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nature Genetics. 36: 1079-83. PMID 15361871 DOI: 10.1038/Ng1421  0.339
2004 Mak HY, Ruvkun G. Intercellular signaling of reproductive development by the C. elegans DAF-9 cytochrome P450. Development (Cambridge, England). 131: 1777-86. PMID 15084462 DOI: 10.1242/Dev.01069  0.405
2004 Ruvkun G, Wightman B, Ha I. The 20 years it took to recognize the importance of tiny RNAs. Cell. 116: S93-6, 2 p following. PMID 15055593 DOI: 10.1016/S0092-8674(04)00034-0  0.309
2004 Bolm M, Chhatwal GS, Jansen WTM, Ausubel FM, Begun J, Kim DH, Moy T, Ruvkun G, Calderwood SB, Sifri CD, Garsin DA. Bacterial Resistance of daf-2 Mutants [2] (multiple letters) Science. 303: 1976. PMID 15044786  0.598
2004 Tewari M, Hu PJ, Ahn JS, Ayivi-Guedehoussou N, Vidalain PO, Li S, Milstein S, Armstrong CM, Boxem M, Butler MD, Busiguina S, Rual JF, Ibarrola N, Chaklos ST, Bertin N, ... ... Ruvkun G, et al. Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network. Molecular Cell. 13: 469-82. PMID 14992718 DOI: 10.1016/S1097-2765(04)00033-4  0.7
2004 Kennedy S, Wang D, Ruvkun G. A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans. Nature. 427: 645-9. PMID 14961122 DOI: 10.1038/Nature02302  0.763
2004 Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proceedings of the National Academy of Sciences of the United States of America. 101: 360-5. PMID 14691248 DOI: 10.1073/Pnas.2333854100  0.766
2004 Ruvkun G. Breaking the silence Nature Genetics. 36: 435-435. DOI: 10.1038/Ng0504-435  0.301
2003 Ruvinsky I, Ruvkun G. Functional tests of enhancer conservation between distantly related species. Development (Cambridge, England). 130: 5133-42. PMID 12944426 DOI: 10.1242/Dev.00711  0.72
2003 Sze JY, Ruvkun G. Activity of the Caenorhabditis elegans UNC-86 POU transcription factor modulates olfactory sensitivity. Proceedings of the National Academy of Sciences of the United States of America. 100: 9560-5. PMID 12883006 DOI: 10.1073/Pnas.1530752100  0.321
2003 Pasquinelli AE, McCoy A, Jiménez E, Saló E, Ruvkun G, Martindale MQ, Baguñà J. Expression of the 22 nucleotide let-7 heterochronic RNA throughout the Metazoa: a role in life history evolution? Evolution & Development. 5: 372-8. PMID 12823453 DOI: 10.1046/J.1525-142X.2003.03044.X  0.353
2003 Garsin DA, Villanueva JM, Begun J, Kim DH, Sifri CD, Calderwood SB, Ruvkun G, Ausubel FM. Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens. Science (New York, N.Y.). 300: 1921. PMID 12817143 DOI: 10.1126/Science.1080147  0.77
2003 Bashirullah A, Pasquinelli AE, Kiger AA, Perrimon N, Ruvkun G, Thummel CS. Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis. Developmental Biology. 259: 1-8. PMID 12812783 DOI: 10.1016/S0012-1606(03)00063-0  0.349
2003 Aspöck G, Ruvkun G, Bürglin TR. The Caenorhabditis elegans ems class homeobox gene ceh-2 is required for M3 pharynx motoneuron function. Development (Cambridge, England). 130: 3369-78. PMID 12810585 DOI: 10.1242/Dev.00551  0.373
2003 Grad Y, Aach J, Hayes GD, Reinhart BJ, Church GM, Ruvkun G, Kim J. Computational and experimental identification of C. elegans microRNAs. Molecular Cell. 11: 1253-63. PMID 12769849 DOI: 10.1016/S1097-2765(03)00153-9  0.772
2003 Lee SS, Kennedy S, Tolonen AC, Ruvkun G. DAF-16 target genes that control C. elegans life-span and metabolism. Science (New York, N.Y.). 300: 644-7. PMID 12690206 DOI: 10.1126/Science.1083614  0.724
2003 Li W, Kennedy SG, Ruvkun G. daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway. Genes & Development. 17: 844-58. PMID 12654727 DOI: 10.1101/Gad.1066503  0.688
2003 Ambros V, Bartel B, Bartel DP, Burge CB, Carrington JC, Chen X, Dreyfuss G, Eddy SR, Griffiths-Jones S, Marshall M, Matzke M, Ruvkun G, Tuschl T. A uniform system for microRNA annotation. Rna (New York, N.Y.). 9: 277-9. PMID 12592000 DOI: 10.1261/Rna.2183803  0.617
2003 Ashrafi K, Chang FY, Watts JL, Fraser AG, Kamath RS, Ahringer J, Ruvkun G. Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature. 421: 268-72. PMID 12529643 DOI: 10.1038/Nature01279  0.661
2003 Lee SS, Lee RY, Fraser AG, Kamath RS, Ahringer J, Ruvkun G. A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nature Genetics. 33: 40-8. PMID 12447374 DOI: 10.1038/Ng1056  0.402
2002 Wolkow CA, Muñoz MJ, Riddle DL, Ruvkun G. Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway. The Journal of Biological Chemistry. 277: 49591-7. PMID 12393910 DOI: 10.1074/Jbc.M207866200  0.334
2002 Pasquinelli AE, Ruvkun G. Control of developmental timing by micrornas and their targets. Annual Review of Cell and Developmental Biology. 18: 495-513. PMID 12142272 DOI: 10.1146/Annurev.Cellbio.18.012502.105832  0.477
2001 Lee RY, Hench J, Ruvkun G. Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Current Biology : Cb. 11: 1950-7. PMID 11747821 DOI: 10.1016/S0960-9822(01)00595-4  0.332
2001 Finch CE, Ruvkun G. The genetics of aging. Annual Review of Genomics and Human Genetics. 2: 435-62. PMID 11701657 DOI: 10.1146/Annurev.Genom.2.1.435  0.365
2001 Ruvkun G. Molecular biology. Glimpses of a tiny RNA world. Science (New York, N.Y.). 294: 797-9. PMID 11679654 DOI: 10.1126/Science.1066315  0.356
2001 Grishok A, Pasquinelli AE, Conte D, Li N, Parrish S, Ha I, Baillie DL, Fire A, Ruvkun G, Mello CC. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell. 106: 23-34. PMID 11461699 DOI: 10.1016/S0092-8674(01)00431-7  0.466
2001 Pierce SB, Costa M, Wisotzkey R, Devadhar S, Homburger SA, Buchman AR, Ferguson KC, Heller J, Platt DM, Pasquinelli AA, Liu LX, Doberstein SK, Ruvkun G. Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes & Development. 15: 672-86. PMID 11274053 DOI: 10.1101/Gad.867301  0.353
2001 Bürglin TR, Ruvkun G. Regulation of ectodermal and excretory function by the C. elegans POU homeobox gene ceh-6. Development (Cambridge, England). 128: 779-90. PMID 11171402  0.316
2001 Cahill CM, Tzivion G, Nasrin N, Ogg S, Dore J, Ruvkun G, Alexander-Bridges M. Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways. The Journal of Biological Chemistry. 276: 13402-10. PMID 11124266 DOI: 10.1074/Jbc.M010042200  0.308
2000 Kagoshima H, Sommer R, Reinhart BJ, Cassata G, Ruvkun G, Bürglin TR. Graded expression of ceh-14 reporters in the hypodermis is induced by a gonadal signal. Development Genes and Evolution. 210: 564-9. PMID 11180807 DOI: 10.1007/S004270000099  0.356
2000 Pasquinelli AE, Reinhart BJ, Slack F, Martindale MQ, Kuroda MI, Maller B, Hayward DC, Ball EE, Degnan B, Müller P, Spring J, Srinivasan A, Fishman M, Finnerty J, Corbo J, ... ... Ruvkun G, et al. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature. 408: 86-9. PMID 11081512 DOI: 10.1038/35040556  0.605
2000 Wolkow CA, Kimura KD, Lee MS, Ruvkun G. Regulation of C. elegans life-span by insulinlike signaling in the nervous system. Science (New York, N.Y.). 290: 147-50. PMID 11021802 DOI: 10.1126/Science.290.5489.147  0.706
2000 Nasrin N, Ogg S, Cahill CM, Biggs W, Nui S, Dore J, Calvo D, Shi Y, Ruvkun G, Alexander-Bridges MC. DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells. Proceedings of the National Academy of Sciences of the United States of America. 97: 10412-7. PMID 10973497 DOI: 10.1073/Pnas.190326997  0.328
2000 Slack FJ, Basson M, Liu Z, Ambros V, Horvitz HR, Ruvkun G. The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor. Molecular Cell. 5: 659-69. PMID 10882102 DOI: 10.1016/S1097-2765(00)80245-2  0.821
2000 Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR, Ruvkun G. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature. 403: 901-6. PMID 10706289 DOI: 10.1038/35002607  0.779
2000 Sze JY, Victor M, Loer C, Shi Y, Ruvkun G. Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant. Nature. 403: 560-4. PMID 10676966 DOI: 10.1038/35000609  0.335
2000 Tissenbaum HA, Hawdon J, Perregaux M, Hotez P, Guarente L, Ruvkun G. A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum. Proceedings of the National Academy of Sciences of the United States of America. 97: 460-5. PMID 10618440 DOI: 10.1073/Pnas.97.1.460  0.317
1999 Sagasti A, Hobert O, Troemel ER, Ruvkun G, Bargmann CI. Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4. Genes & Development. 13: 1794-806. PMID 10421632 DOI: 10.1101/Gad.13.14.1794  0.689
1999 Paradis S, Ailion M, Toker A, Thomas JH, Ruvkun G. A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes & Development. 13: 1438-52. PMID 10364160 DOI: 10.1101/Gad.13.11.1438  0.335
1999 Hobert O, Ruvkun G. Pax genes in Caenorhabditis elegans: a new twist. Trends in Genetics : Tig. 15: 214-6. PMID 10354580 DOI: 10.1016/S0168-9525(99)01731-X  0.524
1999 Hobert O, Tessmar K, Ruvkun G. The Caenorhabditis elegans lim-6 LIM homeobox gene regulates neurite outgrowth and function of particular GABAergic neurons. Development (Cambridge, England). 126: 1547-62. PMID 10068647  0.563
1999 Hobert O, Moerman DG, Clark KA, Beckerle MC, Ruvkun G. A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans. The Journal of Cell Biology. 144: 45-57. PMID 9885243 DOI: 10.1083/Jcb.144.1.45  0.543
1998 Hobert O, Ruvkun G. A common theme for LIM homeobox gene function across phylogeny? The Biological Bulletin. 195: 377-80. PMID 9924780 DOI: 10.2307/1543153  0.636
1998 Slack F, Ruvkun G. Heterochronic genes in development and evolution. The Biological Bulletin. 195: 375-6. PMID 9924779 DOI: 10.2307/1543152  0.603
1998 Ogg S, Ruvkun G. The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Molecular Cell. 2: 887-93. PMID 9885576 DOI: 10.1016/S1097-2765(00)80303-2  0.333
1998 Slack FJ, Ruvkun G. A novel repeat domain that is often associated with RING finger and B-box motifs. Trends in Biochemical Sciences. 23: 474-5. PMID 9868369 DOI: 10.1016/S0968-0004(98)01299-7  0.479
1998 Ruvkun G, Hobert O. The taxonomy of developmental control in Caenorhabditis elegans. Science (New York, N.Y.). 282: 2033-41. PMID 9851920 DOI: 10.1126/Science.282.5396.2033  0.624
1998 Paradis S, Ruvkun G. Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes & Development. 12: 2488-98. PMID 9716402 DOI: 10.1101/Gad.12.16.2488  0.324
1998 Hobert O, D'Alberti T, Liu Y, Ruvkun G. Control of neural development and function in a thermoregulatory network by the LIM homeobox gene lin-11. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 2084-96. PMID 9482795 DOI: 10.1523/Jneurosci.18-06-02084.1998  0.568
1997 Slack F, Ruvkun G. Temporal pattern formation by heterochronic genes. Annual Review of Genetics. 31: 611-34. PMID 9442909 DOI: 10.1146/Annurev.Genet.31.1.611  0.619
1997 Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA, Ruvkun G. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature. 389: 994-9. PMID 9353126 DOI: 10.1038/40194  0.374
1997 Patterson GI, Koweek A, Wong A, Liu Y, Ruvkun G. The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway. Genes & Development. 11: 2679-90. PMID 9334330 DOI: 10.1101/Gad.11.20.2679  0.323
1997 Hobert O, Mori I, Yamashita Y, Honda H, Ohshima Y, Liu Y, Ruvkun G. Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene. Neuron. 19: 345-57. PMID 9292724 DOI: 10.1016/S0896-6273(00)80944-7  0.731
1997 Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science (New York, N.Y.). 277: 942-6. PMID 9252323 DOI: 10.1126/Science.277.5328.942  0.705
1997 Sluder AE, Lindblom T, Ruvkun G. The Caenorhabditis elegans orphan nuclear hormone receptor gene nhr-2 functions in early embryonic development. Developmental Biology. 184: 303-19. PMID 9133437 DOI: 10.1006/Dbio.1997.8544  0.437
1997 Sze JY, Liu Y, Ruvkun G. VP16-activation of the C. elegans neural specification transcription factor UNC-86 suppresses mutations in downstream genes and causes defects in neural migration and axon outgrowth. Development (Cambridge, England). 124: 1159-68. PMID 9102303  0.339
1996 Ha I, Wightman B, Ruvkun G. A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation. Genes & Development. 10: 3041-50. PMID 8957004 DOI: 10.1101/Gad.10.23.3041  0.389
1996 Morris JZ, Tissenbaum HA, Ruvkun G. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature. 382: 536-9. PMID 8700226 DOI: 10.1038/382536A0  0.307
1996 Barnes TM, Jin Y, Horvitz HR, Ruvkun G, Hekimi S. The Caenorhabditis elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and nonspecific lipid transfer protein. Journal of Neurochemistry. 67: 46-57. PMID 8667025 DOI: 10.1046/J.1471-4159.1996.67010046.X  0.672
1996 Baumeister R, Liu Y, Ruvkun G. Lineage-specific regulators couple cell lineage asymmetry to the transcription of the Caenorhabditis elegans POU gene unc-86 during neurogenesis. Genes & Development. 10: 1395-410. PMID 8647436 DOI: 10.1101/Gad.10.11.1395  0.374
1994 Greenstein D, Hird S, Plasterk RH, Andachi Y, Kohara Y, Wang B, Finney M, Ruvkun G. Targeted mutations in the Caenorhabditis elegans POU homeo box gene ceh-18 cause defects in oocyte cell cycle arrest, gonad migration, and epidermal differentiation. Genes & Development. 8: 1935-48. PMID 7958868 DOI: 10.1101/Gad.8.16.1935  0.702
1993 Wightman B, Ha I, Ruvkun G. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell. 75: 855-62. PMID 8252622 DOI: 10.1016/0092-8674(93)90530-4  0.451
1993 Bürglin TR, Ruvkun G. The Caenorhabditis elegans homeobox gene cluster. Current Opinion in Genetics & Development. 3: 615-20. PMID 7902148 DOI: 10.1016/0959-437X(93)90097-9  0.34
1992 Bürglin TR, Ruvkun G. New motif in PBX genes. Nature Genetics. 1: 319-20. PMID 1363814 DOI: 10.1038/Ng0892-319  0.355
1992 Xue D, Finney M, Ruvkun G, Chalfie M. Regulation of the mec-3 gene by the C.elegans homeoproteins UNC-86 and MEC-3. The Embo Journal. 11: 4969-79. PMID 1361171 DOI: 10.1002/J.1460-2075.1992.Tb05604.X  0.429
1992 Miller DM, Shen MM, Shamu CE, Bürglin TR, Ruvkun G, Dubois ML, Ghee M, Wilson L. C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons. Nature. 355: 841-5. PMID 1347150 DOI: 10.1038/355841A0  0.362
1991 Ruvkun G, Finney M. Regulation of transcription and cell identity by POU domain proteins. Cell. 64: 475-8. PMID 1991317 DOI: 10.1016/0092-8674(91)90227-P  0.396
1991 Arasu P, Wightman B, Ruvkun G. Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes, lin-4 and lin-28. Genes & Development. 5: 1825-33. PMID 1916265 DOI: 10.1101/Gad.5.10.1825  0.397
1991 Wightman B, Bürglin TR, Gatto J, Arasu P, Ruvkun G. Negative regulatory sequences in the lin-14 3'-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development. Genes & Development. 5: 1813-24. PMID 1916264 DOI: 10.1101/Gad.5.10.1813  0.393
1991 Ruvkun G, Wightman B, Bürglin T, Arasu P. Dominant gain-of-function mutations that lead to misregulation of the C. elegans heterochronic gene lin-14, and the evolutionary implications of dominant mutations in pattern-formation genes. Development (Cambridge, England). Supplement. 1: 47-54. PMID 1742500  0.337
1990 Ruvkun G, Gilbert W, Horvitz HR. Detection of mutations and DNA polymorphisms using whole genome Southern Cross hybridization. Nucleic Acids Research. 18: 809-15. PMID 2315039 DOI: 10.1093/Nar/18.4.809  0.749
1990 Finney M, Ruvkun G. The unc-86 gene product couples cell lineage and cell identity in C. elegans. Cell. 63: 895-905. PMID 2257628 DOI: 10.1016/0092-8674(90)90493-X  0.362
1989 Ruvkun G, Giusto J. The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal developmental switch. Nature. 338: 313-9. PMID 2922060 DOI: 10.1038/338313A0  0.386
1989 Bürglin TR, Finney M, Coulson A, Ruvkun G. Caenorhabditis elegans has scores of homoeobox-containing genes. Nature. 341: 239-43. PMID 2571091 DOI: 10.1038/341239A0  0.409
1989 Ruvkun G, Ambros V, Coulson A, Waterston R, Sulston J, Horvitz HR. Molecular genetics of the Caenorhabditis elegans heterochronic gene lin-14. Genetics. 121: 501-16. PMID 2565854  0.752
1989 Bürglin TR, Finney M, Coulson A, Ruvkun G. Caenorbabditis elegans has scores of homeobox-containing genes Trends in Genetics. 5: 393. DOI: 10.1016/0168-9525(89)90189-3  0.354
1988 Herr W, Sturm RA, Clerc RG, Corcoran LM, Baltimore D, Sharp PA, Ingraham HA, Rosenfeld MG, Finney M, Ruvkun G. The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products. Genes & Development. 2: 1513-6. PMID 3215510 DOI: 10.1101/Gad.2.12A.1513  0.537
1988 Finney M, Ruvkun G, Horvitz HR. The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors. Cell. 55: 757-69. PMID 2903797 DOI: 10.1016/0092-8674(88)90132-8  0.701
1982 Ruvkun GB, Long SR, Meade HM, van den Bos RC, Ausubel FM. ISRm1: A Rhizobium meliloti insertion sequence that transposes preferentially into nitrogen fixation genes. Journal of Molecular and Applied Genetics. 1: 405-18. PMID 6296251  0.625
1982 Ruvkun GB, Sundaresan V, Ausubel FM. Specific protection of nucleotides in the lac operator from DMS methylation and DNase I nicking by crude bacterial cell extracts. Gene. 18: 247-55. PMID 6290328 DOI: 10.1016/0378-1119(82)90162-7  0.638
1982 Ruvkun GB, Sundaresan V, Ausubel FM. Directed transposon Tn5 mutagenesis and complementation analysis of Rhizobium meliloti symbiotic nitrogen fixation genes. Cell. 29: 551-9. PMID 6288262 DOI: 10.1016/0092-8674(82)90171-4  0.689
1982 Meade HM, Long SR, Ruvkun GB, Brown SE, Ausubel FM. Physical and genetic characterization of symbiotic and auxotrophic mutants of Rhizobium meliloti induced by transposon Tn5 mutagenesis. Journal of Bacteriology. 149: 114-22. PMID 6274841 DOI: 10.1128/Jb.149.1.114-122.1982  0.606
1981 Ruvkun GB, Ausubel FM. A general method for site-directed mutagenesis in prokaryotes. Nature. 289: 85-8. PMID 6256652 DOI: 10.1038/289085A0  0.507
1981 Ruvkun GB, Long SR, Meade HM, Ausubel FM. Molecular Genetic Analysis of Klebsiella Pneumoniae Nitrogen-fixation (nif) Genes: Appendix: Molecular Genetics of Symbiotic Nitrogen Fixation Cold Spring Harbor Symposia On Quantitative Biology. 45: 487-499. DOI: 10.1101/Sqb.1981.045.01.065  0.597
1980 Ruvkun GB, Ausubel FM. Interspecies homology of nitrogenase genes. Proceedings of the National Academy of Sciences of the United States of America. 77: 191-5. PMID 6987649 DOI: 10.1073/Pnas.77.1.191  0.482
Low-probability matches (unlikely to be authored by this person)
2012 Shore DE, Carr CE, Ruvkun G. Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways. Plos Genetics. 8: e1002792. PMID 22829775 DOI: 10.1371/journal.pgen.1002792  0.296
2008 Wang MC, O'Rourke EJ, Ruvkun G. Fat metabolism links germline stem cells and longevity in C. elegans. Science (New York, N.Y.). 322: 957-60. PMID 18988854 DOI: 10.1126/Science.1162011  0.296
1999 Davidson EH, Ruvkun G. Themes from a NASA workshop on gene regulatory processes in development and evolution. The Journal of Experimental Zoology. 285: 104-15. PMID 10440721 DOI: 10.1002/(Sici)1097-010X(19990815)285:2<104::Aid-Jez2>3.0.Co;2-Z  0.295
2019 Govindan JA, Jayamani E, Ruvkun G. ROS-based lethality of mitochondrial electron transport mutants grown on siderophore iron release mutants. Proceedings of the National Academy of Sciences of the United States of America. PMID 31591219 DOI: 10.1073/Pnas.1912628116  0.292
2013 O'Rourke EJ, Kuballa P, Xavier R, Ruvkun G. ω-6 Polyunsaturated fatty acids extend life span through the activation of autophagy. Genes & Development. 27: 429-40. PMID 23392608 DOI: 10.1101/Gad.205294.112  0.292
2013 Schwartz S, Agarwala SD, Mumbach MR, Jovanovic M, Mertins P, Shishkin A, Tabach Y, Mikkelsen TS, Satija R, Ruvkun G, Carr SA, Lander ES, Fink GR, Regev A. High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis. Cell. 155: 1409-21. PMID 24269006 DOI: 10.1016/J.Cell.2013.10.047  0.284
1994 Gottlieb S, Ruvkun G. daf-2, daf-16 and daf-23: genetically interacting genes controlling Dauer formation in Caenorhabditis elegans. Genetics. 137: 107-20. PMID 8056303  0.284
2013 O'Rourke EJ, Ruvkun G. MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. Nature Cell Biology. 15: 668-76. PMID 23604316 DOI: 10.1038/Ncb2741  0.283
2019 Mao K, Ji F, Breen P, Sewell A, Han M, Sadreyev R, Ruvkun G. Mitochondrial Dysfunction in C. elegans Activates Mitochondrial Relocalization and Nuclear Hormone Receptor-Dependent Detoxification Genes. Cell Metabolism. PMID 30799287 DOI: 10.1016/J.Cmet.2019.01.022  0.28
2019 Mojarro A, Hachey J, Bailey R, Brown M, Doebler R, Ruvkun G, Zuber MT, Carr CE. Nucleic Acid Extraction and Sequencing from Low-Biomass Synthetic Mars Analog Soils for Life Detection. Astrobiology. PMID 31204862 DOI: 10.1089/Ast.2018.1929  0.278
2020 Wei W, Ruvkun G. Lysosomal activity regulates mitochondrial dynamics through vitamin B12 metabolism. Proceedings of the National Academy of Sciences of the United States of America. PMID 32737159 DOI: 10.1073/Pnas.2008021117  0.274
2009 Butcher RA, Ragains JR, Li W, Ruvkun G, Clardy J, Mak HY. Biosynthesis of the Caenorhabditis elegans dauer pheromone. Proceedings of the National Academy of Sciences of the United States of America. 106: 1875-9. PMID 19174521 DOI: 10.1073/Pnas.0810338106  0.272
2019 Lehrbach NJ, Ruvkun G. Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity. Elife. 8. PMID 30973820 DOI: 10.7554/Elife.44425  0.271
2006 Hu PJ, Xu J, Ruvkun G. Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling. Plos Genetics. 2: e99. PMID 16839187 DOI: 10.1371/journal.pgen.0020099  0.268
2013 Carr CE, Rowedder H, Lui CS, Zlatkovsky I, Papalias CW, Bolander J, Myers JW, Bustillo J, Rothberg JM, Zuber MT, Ruvkun G. Radiation resistance of sequencing chips for in situ life detection. Astrobiology. 13: 560-9. PMID 23734755 DOI: 10.1089/Ast.2012.0923  0.268
2018 Pontefract A, Hachey J, Zuber MT, Ruvkun G, Carr CE. Sequencing nothing: Exploring failure modes of nanopore sensing and implications for life detection. Life Sciences in Space Research. 18: 80-86. PMID 30100151 DOI: 10.1016/J.Lssr.2018.05.004  0.267
2022 Ruvkun G, Lehrbach N. Regulation and Functions of the ER-Associated Nrf1 Transcription Factor. Cold Spring Harbor Perspectives in Biology. PMID 35940907 DOI: 10.1101/cshperspect.a041266  0.264
2021 Charlesworth AG, Seroussi U, Lehrbach NJ, Renaud MS, Sundby AE, Molnar RI, Lao RX, Willis AR, Woock JR, Aber MJ, Diao AJ, Reinke AW, Ruvkun G, Claycomb JM. Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility. Nucleic Acids Research. PMID 34329465 DOI: 10.1093/nar/gkab619  0.263
2013 Carr CE, Rowedder H, Vafadari C, Lui CS, Cascio E, Zuber MT, Ruvkun G. Radiation resistance of biological reagents for in situ life detection. Astrobiology. 13: 68-78. PMID 23330963 DOI: 10.1089/Ast.2012.0869  0.258
2019 Ast T, Meisel JD, Patra S, Wang H, Grange RMH, Kim SH, Calvo SE, Orefice LL, Nagashima F, Ichinose F, Zapol WM, Ruvkun G, Barondeau DP, Mootha VK. Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis. Cell. PMID 31031004 DOI: 10.1016/J.Cell.2019.03.045  0.257
2022 Snoozy J, Breen PC, Ruvkun G, Warnhoff K. /MOCS2A is necessary for molybdenum cofactor synthesis in . Micropublication Biology. 2022. PMID 35224462 DOI: 10.17912/micropub.biology.000531  0.249
2018 Mojarro A, Hachey J, Ruvkun G, Zuber MT, Carr CE. CarrierSeq: a sequence analysis workflow for low-input nanopore sequencing. Bmc Bioinformatics. 19: 108. PMID 29587645 DOI: 10.1186/S12859-018-2124-3  0.245
2017 Mojarro A, Ruvkun G, Zuber MT, Carr CE. Nucleic Acid Extraction from Synthetic Mars Analog Soils for in situ Life Detection. Astrobiology. PMID 28704064 DOI: 10.1089/Ast.2016.1535  0.243
1998 Guarente L, Ruvkun G, Amasino R. Aging, life span, and senescence. Proceedings of the National Academy of Sciences of the United States of America. 95: 11034-6. PMID 9736682 DOI: 10.1073/Pnas.95.19.11034  0.242
2017 Pontefract A, Zhu TF, Walker VK, Hepburn H, Lui C, Zuber MT, Ruvkun G, Carr CE. Microbial Diversity in a Hypersaline Sulfate Lake: A Terrestrial Analog of Ancient Mars. Frontiers in Microbiology. 8: 1819. PMID 29018418 DOI: 10.3389/Fmicb.2017.01819  0.239
2019 Lehrbach NJ, Ruvkun G. Author response: Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity Elife. DOI: 10.7554/Elife.44425.021  0.236
2015 O'Rourke EJ, Ruvkun G. Corrigendum: MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability Nature Cell Biology. 17: 104-104. DOI: 10.1038/Ncb3085  0.233
1992 Ruvkun G. Cell signalling. A molecular growth industry. Nature. 360: 711-2. PMID 1334532 DOI: 10.1038/360711A0  0.23
2022 Mao K, Breen P, Ruvkun G. The ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways. Proceedings of the National Academy of Sciences of the United States of America. 119: e2215966119. PMID 36445965 DOI: 10.1073/pnas.2215966119  0.224
2002 Lee SS, Ruvkun G. Longevity: don't hold your breath. Nature. 418: 287-8. PMID 12124610 DOI: 10.1038/418287A  0.223
2020 Mao K, Breen P, Ruvkun G. Mitochondrial dysfunction induces RNA interference in C. elegans through a pathway homologous to the mammalian RIG-I antiviral response. Plos Biology. 18: e3000996. PMID 33264285 DOI: 10.1371/journal.pbio.3000996  0.22
2018 Carr CE, Bryan NC, Saboda KN, Bhattaru SA, Ruvkun G, Zuber MT. Acceleration profiles and processing methods for parabolic flight. Npj Microgravity. 4: 14. PMID 30109261 DOI: 10.1038/S41526-018-0050-3  0.219
2016 Rettberg P, Anesio AM, Baker VR, Baross JA, Cady SL, Detsis E, Foreman CM, Hauber E, Ori GG, Pearce DA, Renno NO, Ruvkun G, Sattler B, Saunders MP, Smith DH, et al. Planetary Protection and Mars Special Regions-A Suggestion for Updating the Definition. Astrobiology. PMID 26848950 DOI: 10.1089/Ast.2016.1472  0.216
2002 Sze JY, Zhang S, Li J, Ruvkun G. The C. elegans POU-domain transcription factor UNC-86 regulates the tph-1 tryptophan hydroxylase gene and neurite outgrowth in specific serotonergic neurons. Development (Cambridge, England). 129: 3901-11. PMID 12135927  0.209
1998 Tissenbaum HA, Ruvkun G. An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans. Genetics. 148: 703-17. PMID 9504918  0.204
2016 Lehrbach NJ, Ruvkun G. Author response: Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1 Elife. DOI: 10.7554/Elife.17721.016  0.198
2021 Warnhoff K, Hercher TW, Mendel RR, Ruvkun G. Protein-bound molybdenum cofactor is bioavailable and rescues molybdenum cofactor-deficient . Genes & Development. 35: 212-217. PMID 33446569 DOI: 10.1101/gad.345579.120  0.19
2023 Warnhoff K, Snoozy J, Breen PC, Ruvkun G. Hypoxia-inducible factor promotes cysteine homeostasis in . Biorxiv : the Preprint Server For Biology. PMID 37205365 DOI: 10.1101/2023.05.04.538701  0.183
1991 Bürglin TR, Ruvkun G, Coulson A, Hawkins NC, McGhee JD, Schaller D, Wittmann C, Müller F, Waterston RH. Nematode homeobox cluster. Nature. 351: 703. PMID 1676487 DOI: 10.1038/351703A0  0.181
2001 Reinhart BJ, Ruvkun G. Isoform-specific mutations in the Caenorhabditis elegans heterochronic gene lin-14 affect stage-specific patterning. Genetics. 157: 199-209. PMID 11139502  0.18
2003 Ruvkun GB. The tiny RNA world. Harvey Lectures. 99: 1-21. PMID 15984549  0.173
2022 Ji F, Bonilla G, Krykbaev R, Ruvkun G, Tabach Y, Sadreyev RI. DEPCOD: a tool to detect and visualize co-evolution of protein domains. Nucleic Acids Research. PMID 35536332 DOI: 10.1093/nar/gkac349  0.166
1998 Ruvkun G, Sze JY, Hubert O. Transcriptional control of neural function in C elegans Faseb Journal. 12: A1322.  0.162
2020 Bryan NC, Lebreton F, Gilmore M, Ruvkun G, Zuber MT, Carr CE. Genomic and Functional Characterization of Isolates Recovered From the International Space Station and Their Potential for Pathogenicity. Frontiers in Microbiology. 11: 515319. PMID 33505359 DOI: 10.3389/fmicb.2020.515319  0.158
2024 Meisel JD, Miranda M, Skinner OS, Wiesenthal PP, Wellner SM, Jourdain AA, Ruvkun G, Mootha VK. Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism. Cell. PMID 38215760 DOI: 10.1016/j.cell.2023.12.010  0.152
2000 Ruvkun G. ABSTRACT The taxonomy of animal developmental controlgenes revealed by the first complete animal genome sequence Biochemistry and Cell Biology. 78: 650. DOI: 10.1139/O00-048  0.121
2024 Warnhoff K, Bhattacharya S, Snoozy J, Breen PC, Ruvkun G. Hypoxia-inducible factor induces cysteine dioxygenase and promotes cysteine homeostasis in . Elife. 12. PMID 38349720 DOI: 10.7554/eLife.89173  0.12
2020 Carr CE, Bryan NC, Saboda KN, Bhattaru SA, Ruvkun G, Zuber MT. Nanopore sequencing at Mars, Europa, and microgravity conditions. Npj Microgravity. 6: 24. PMID 32964110 DOI: 10.1038/s41526-020-00113-9  0.11
2004 Bolm M, Chhatwal GS, Jansen WTM, Ausubel FM, Begun J, Kim DH, Moy T, Ruvkun G, Calderwood SB, Sifri CD, Garsin DA. Bacterial Resistance of daf-2 Mutants [2] (multiple letters) Science. 303: 1976. PMID 15044786  0.109
2020 Carr CE, Bryan NC, Saboda KN, Bhattaru SA, Ruvkun G, Zuber MT. Nanopore sequencing at Mars, Europa, and microgravity conditions. Npj Microgravity. 6: 24. PMID 34489469 DOI: 10.1038/s41526-020-00113-9  0.1
2013 Carr CE, Zuber MT, Ruvkun G. Life detection with the Enceladus Orbiting Sequencer Ieee Aerospace Conference Proceedings. DOI: 10.1109/AERO.2013.6497129  0.083
2014 Govindan JA, Ruvkun G. Pathogens. Virulence. 5: 695-6. PMID 25513769 DOI: 10.4161/viru.36667  0.075
2022 Govindan JA, Jayamani E, Zhang X, Breen P, Larkins-Ford J, Mylonakis E, Ruvkun G. Author Correction: Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans. Nature Cell Biology. PMID 35411089 DOI: 10.1038/s41556-022-00868-1  0.071
2003 Komaroff AL, Ruvkun G. Unraveling the secrets of the cell. Newsweek. 142: 96. PMID 14712576  0.071
2011 Lui C, Carr CE, Rowedder H, Ruvkun G, Zuber M. SETG: An instrument for detection of life on Mars ancestrally related to life on Earth Ieee Aerospace Conference Proceedings. DOI: 10.1109/AERO.2011.5747299  0.059
2004 Ruvkun G. DNA approach to Mars New Scientist. 181: 19.  0.04
2004 Ruvkun G. DNA approach to Mars New Scientist. 181: 19.  0.04
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