Patricia L. Opresko, Ph.D. - Publications

2000 Pennsylvania State University, State College, PA, United States 
Biochemistry, Molecular Biology

55 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Orenstein A, Berlyoung AS, Rastede EE, Pham HH, Fouquerel E, Murphy CT, Leibowitz BJ, Yu J, Srivastava T, Armitage BA, Opresko PL. γPNA FRET Pair Miniprobes for Quantitative Fluorescent In Situ Hybridization to Telomeric DNA in Cells and Tissue. Molecules (Basel, Switzerland). 22. PMID 29207465 DOI: 10.3390/molecules22122117  0.4
2016 Tippana R, Hwang H, Opresko PL, Bohr VA, Myong S. Single-molecule imaging reveals a common mechanism shared by G-quadruplex-resolving helicases. Proceedings of the National Academy of Sciences of the United States of America. PMID 27407146 DOI: 10.1073/pnas.1603724113  1
2016 Lin J, Countryman P, Chen H, Pan H, Fan Y, Jiang Y, Kaur P, Miao W, Gurgel G, You C, Piehler J, Kad NM, Riehn R, Opresko PL, Smith S, et al. Functional interplay between SA1 and TRF1 in telomeric DNA binding and DNA-DNA pairing. Nucleic Acids Research. PMID 27298259 DOI: 10.1093/nar/gkw518  1
2016 Kaur P, Wu D, Lin J, Countryman P, Bradford KC, Erie DA, Riehn R, Opresko PL, Wang H. Enhanced electrostatic force microscopy reveals higher-order DNA looping mediated by the telomeric protein TRF2. Scientific Reports. 6: 20513. PMID 26856421 DOI: 10.1038/srep20513  1
2015 Parikh D, Fouquerel E, Murphy CT, Wang H, Opresko PL. Telomeres are partly shielded from ultraviolet-induced damage and proficient for nucleotide excision repair of photoproducts. Nature Communications. 6: 8214. PMID 26351258 DOI: 10.1038/ncomms9214  1
2014 Pope-Varsalona H, Liu FJ, Guzik L, Opresko PL. Polymerase η suppresses telomere defects induced by DNA damaging agents. Nucleic Acids Research. 42: 13096-109. PMID 25355508 DOI: 10.1093/nar/gku1030  1
2014 Pham HH, Murphy CT, Sureshkumar G, Ly DH, Opresko PL, Armitage BA. Cooperative hybridization of γPNA miniprobes to a repeating sequence motif and application to telomere analysis. Organic & Biomolecular Chemistry. 12: 7345-54. PMID 25115693 DOI: 10.1039/c4ob00953c  1
2014 Murphy CT, Gupta A, Armitage BA, Opresko PL. Hybridization of G-quadruplex-forming peptide nucleic acids to guanine-rich DNA templates inhibits DNA polymerase η extension. Biochemistry. 53: 5315-22. PMID 25068499 DOI: 10.1021/bi5006859  1
2014 Hwang H, Kreig A, Calvert J, Lormand J, Kwon Y, Daley JM, Sung P, Opresko PL, Myong S. Telomeric overhang length determines structural dynamics and accessibility to telomerase and ALT-associated proteins. Structure (London, England : 1993). 22: 842-53. PMID 24836024 DOI: 10.1016/j.str.2014.03.013  1
2014 Croteau DL, Popuri V, Opresko PL, Bohr VA. Human RecQ helicases in DNA repair, recombination, and replication. Annual Review of Biochemistry. 83: 519-52. PMID 24606147 DOI: 10.1146/annurev-biochem-060713-035428  1
2014 Lin J, Kaur P, Countryman P, Opresko PL, Wang H. Unraveling secrets of telomeres: one molecule at a time. Dna Repair. 20: 142-53. PMID 24569170 DOI: 10.1016/j.dnarep.2014.01.012  1
2014 Lin J, Countryman P, Buncher N, Kaur P, E L, Zhang Y, Gibson G, You C, Watkins SC, Piehler J, Opresko PL, Kad NM, Wang H. TRF1 and TRF2 use different mechanisms to find telomeric DNA but share a novel mechanism to search for protein partners at telomeres. Nucleic Acids Research. 42: 2493-504. PMID 24271387 DOI: 10.1093/nar/gkt1132  1
2013 Lormand JD, Buncher N, Murphy CT, Kaur P, Lee MY, Burgers P, Wang H, Kunkel TA, Opresko PL. DNA polymerase δ stalls on telomeric lagging strand templates independently from G-quadruplex formation. Nucleic Acids Research. 41: 10323-33. PMID 24038470 DOI: 10.1093/nar/gkt813  1
2012 Hwang H, Buncher N, Opresko PL, Myong S. POT1-TPP1 regulates telomeric overhang structural dynamics. Structure (London, England : 1993). 20: 1872-80. PMID 22981946 DOI: 10.1016/j.str.2012.08.018  1
2012 Damerla RR, Knickelbein KE, Strutt S, Liu FJ, Wang H, Opresko PL. Werner syndrome protein suppresses the formation of large deletions during the replication of human telomeric sequences. Cell Cycle (Georgetown, Tex.). 11: 3036-44. PMID 22871734 DOI: 10.4161/cc.21399  1
2012 Miller AS, Balakrishnan L, Buncher NA, Opresko PL, Bambara RA. Telomere proteins POT1, TRF1 and TRF2 augment long-patch base excision repair in vitro. Cell Cycle (Georgetown, Tex.). 11: 998-1007. PMID 22336916 DOI: 10.4161/cc.11.5.19483  1
2011 Choi S, Wang W, Ribeiro AJ, Kalinowski A, Gregg SQ, Opresko PL, Niedernhofer LJ, Rohde GK, Dahl KN. Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders. Nucleus (Austin, Tex.). 2: 570-9. PMID 22127259 DOI: 10.4161/nucl.2.6.17798  1
2011 O'Donovan A, Pantell MS, Puterman E, Dhabhar FS, Blackburn EH, Yaffe K, Cawthon RM, Opresko PL, Hsueh WC, Satterfield S, Newman AB, Ayonayon HN, Rubin SM, Harris TB, Epel ES, et al. Cumulative inflammatory load is associated with short leukocyte telomere length in the Health, Aging and Body Composition Study. Plos One. 6: e19687. PMID 21602933 DOI: 10.1371/journal.pone.0019687  1
2011 Sanders JL, Iannaccone A, Boudreau RM, Conley YP, Opresko PL, Hsueh WC, Cummings SR, Cawthon RM, Harris TB, Nalls MA, Kritchevsky SB, Newman AB. The association of cataract with leukocyte telomere length in older adults: defining a new marker of aging. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 66: 639-45. PMID 21382885 DOI: 10.1093/gerona/glr034  1
2011 Wang H, Nora GJ, Ghodke H, Opresko PL. Single molecule studies of physiologically relevant telomeric tails reveal POT1 mechanism for promoting G-quadruplex unfolding. The Journal of Biological Chemistry. 286: 7479-89. PMID 21183684 DOI: 10.1074/jbc.M110.205641  1
2010 Damerla RR, Knickelbein KE, Kepchia D, Jackson A, Armitage BA, Eckert KA, Opresko PL. Telomeric repeat mutagenicity in human somatic cells is modulated by repeat orientation and G-quadruplex stability. Dna Repair. 9: 1119-29. PMID 20800555 DOI: 10.1016/j.dnarep.2010.07.014  1
2010 Liu FJ, Barchowsky A, Opresko PL. The Werner syndrome protein suppresses telomeric instability caused by chromium (VI) induced DNA replication stress. Plos One. 5: e11152. PMID 20585393 DOI: 10.1371/journal.pone.0011152  1
2010 Kusumoto-Matsuo R, Opresko PL, Ramsden D, Tahara H, Bohr VA. Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loops. Aging. 2: 274-84. PMID 20519774 DOI: v2/n5/full/100141.html  1
2010 Nora GJ, Buncher NA, Opresko PL. Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner syndrome helicase. Nucleic Acids Research. 38: 3984-98. PMID 20215438 DOI: 10.1093/nar/gkq144  1
2010 Shah SN, Opresko PL, Meng X, Lee MY, Eckert KA. DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D. Nucleic Acids Research. 38: 1149-62. PMID 19969545 DOI: 10.1093/nar/gkp1131  1
2009 Sowd G, Wang H, Pretto D, Chazin WJ, Opresko PL. Replication protein A stimulates the Werner syndrome protein branch migration activity. The Journal of Biological Chemistry. 284: 34682-91. PMID 19812417 DOI: 10.1074/jbc.M109.049031  1
2009 Liu FJ, Barchowsky A, Opresko PL. The Werner syndrome protein functions in repair of Cr(VI)-induced replication-associated DNA damage. Toxicological Sciences : An Official Journal of the Society of Toxicology. 110: 307-18. PMID 19487340 DOI: 10.1093/toxsci/kfp104  1
2009 Sanders JL, Cauley JA, Boudreau RM, Zmuda JM, Strotmeyer ES, Opresko PL, Hsueh WC, Cawthon RM, Li R, Harris TB, Kritchevsky SB, Newman AB. Leukocyte Telomere Length Is Not Associated With BMD, Osteoporosis, or Fracture in Older Adults: Results From the Health, Aging and Body Composition Study. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 24: 1531-6. PMID 19338455 DOI: 10.1359/jbmr.090318  1
2009 Opresko PL, Sowd G, Wang H. The Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradation. Plos One. 4: e4825. PMID 19283071 DOI: 10.1371/journal.pone.0004825  1
2008 Sowd G, Lei M, Opresko PL. Mechanism and substrate specificity of telomeric protein POT1 stimulation of the Werner syndrome helicase Nucleic Acids Research. 36: 4242-4256. PMID 18583366 DOI: 10.1093/nar/gkn385  1
2008 Opresko PL. Telomere ResQue and preservation--roles for the Werner syndrome protein and other RecQ helicases. Mechanisms of Ageing and Development. 129: 79-90. PMID 18054793 DOI: 10.1016/j.mad.2007.10.007  1
2007 Opresko PL, Calvo JP, von Kobbe C. Role for the Werner syndrome protein in the promotion of tumor cell growth. Mechanisms of Ageing and Development. 128: 423-36. PMID 17624410 DOI: 10.1016/j.mad.2007.05.009  1
2006 Eller MS, Liao X, Liu S, Hanna K, Bäckvall H, Opresko PL, Bohr VA, Gilchrest BA. A role for WRN in telomere-based DNA damage responses. Proceedings of the National Academy of Sciences of the United States of America. 103: 15073-8. PMID 17015833 DOI: 10.1073/pnas.0607332103  1
2006 Brosh RM, Opresko PL, Bohr VA. Enzymatic mechanism of the WRN helicase/nuclease. Methods in Enzymology. 409: 52-85. PMID 16793395 DOI: 10.1016/S0076-6879(05)09004-X  1
2006 Cheng WH, Kusumoto R, Opresko PL, Sui X, Huang S, Nicolette ML, Paull TT, Campisi J, Seidman M, Bohr VA. Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links. Nucleic Acids Research. 34: 2751-60. PMID 16714450 DOI: 10.1093/nar/gkl362  1
2006 Zhang P, Furukawa K, Opresko PL, Xu X, Bohr VA, Mattson MP. TRF2 dysfunction elicits DNA damage responses associated with senescence in proliferating neural cells and differentiation of neurons. Journal of Neurochemistry. 97: 567-81. PMID 16539655 DOI: 10.1111/j.1471-4159.2006.03779.x  1
2006 Harrigan JA, Wilson DM, Prasad R, Opresko PL, Beck G, May A, Wilson SH, Bohr VA. The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta. Nucleic Acids Research. 34: 745-54. PMID 16449207 DOI: 10.1093/nar/gkj475  1
2006 Muftuoglu M, Wong HK, Imam SZ, Wilson DM, Bohr VA, Opresko PL. Telomere repeat binding factor 2 interacts with base excision repair proteins and stimulates DNA synthesis by DNA polymerase beta. Cancer Research. 66: 113-24. PMID 16397223 DOI: 10.1158/0008-5472.CAN-05-2742  1
2005 Opresko PL, Mason PA, Podell ER, Lei M, Hickson ID, Cech TR, Bohr VA. POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates. The Journal of Biological Chemistry. 280: 32069-80. PMID 16030011 DOI: 10.1074/jbc.M505211200  1
2005 Opresko PL, Fan J, Danzy S, Wilson DM, Bohr VA. Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2. Nucleic Acids Research. 33: 1230-9. PMID 15731343 DOI: 10.1093/nar/gki273  1
2005 Lee JW, Harrigan J, Opresko PL, Bohr VA. Pathways and functions of the Werner syndrome protein. Mechanisms of Ageing and Development. 126: 79-86. PMID 15610765 DOI: 10.1016/j.mad.2004.09.011  1
2004 Opresko PL, Otterlei M, Graakjaer J, Bruheim P, Dawut L, Kølvraa S, May A, Seidman MM, Bohr VA. The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2. Molecular Cell. 14: 763-74. PMID 15200954 DOI: 10.1016/j.molcel.2004.05.023  1
2004 Cheng WH, von Kobbe C, Opresko PL, Arthur LM, Komatsu K, Seidman MM, Carney JP, Bohr VA. Linkage between Werner syndrome protein and the Mre11 complex via Nbs1. The Journal of Biological Chemistry. 279: 21169-76. PMID 15026416 DOI: 10.1074/jbc.M312770200  1
2004 Opresko PL, Cheng WH, Bohr VA. Junction of RecQ helicase biochemistry and human disease. The Journal of Biological Chemistry. 279: 18099-102. PMID 15023996 DOI: 10.1074/jbc.R300034200  1
2003 Laine JP, Opresko PL, Indig FE, Harrigan JA, von Kobbe C, Bohr VA. Werner protein stimulates topoisomerase I DNA relaxation activity. Cancer Research. 63: 7136-46. PMID 14612507  1
2003 von Kobbe C, Harrigan JA, May A, Opresko PL, Dawut L, Cheng WH, Bohr VA. Central role for the Werner syndrome protein/poly(ADP-ribose) polymerase 1 complex in the poly(ADP-ribosyl)ation pathway after DNA damage. Molecular and Cellular Biology. 23: 8601-13. PMID 14612404 DOI: 10.1128/MCB.23.23.8601-8613.2003  1
2003 Cheng WH, von Kobbe C, Opresko PL, Fields KM, Ren J, Kufe D, Bohr VA. Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution. Molecular and Cellular Biology. 23: 6385-95. PMID 12944467 DOI: 10.1128/MCB.23.18.6385-6395.2003  1
2003 Opresko PL, Cheng WH, von Kobbe C, Harrigan JA, Bohr VA. Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process. Carcinogenesis. 24: 791-802. PMID 12771022 DOI: 10.1093/carcin/bgg034  1
2003 Harrigan JA, Opresko PL, von Kobbe C, Kedar PS, Prasad R, Wilson SH, Bohr VA. The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity. The Journal of Biological Chemistry. 278: 22686-95. PMID 12665521 DOI: 10.1074/jbc.M213103200  1
2002 Opresko PL, von Kobbe C, Laine JP, Harrigan J, Hickson ID, Bohr VA. Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases. The Journal of Biological Chemistry. 277: 41110-9. PMID 12181313 DOI: 10.1074/jbc.M205396200  1
2001 Brosh RM, Von Kobbe C, Sommers JA, Karmakar P, Opresko PL, Piotrowski J, Dianova I, Dianov GL, Bohr VA. Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity Embo Journal. 20: 5791-5801. PMID 11598021 DOI: 10.1093/emboj/20.20.5791  1
2001 Opresko PL, Laine JP, Brosh RM, Seidman MM, Bohr VA. Coordinate Action of the Helicase and 3′ to 5′ Exonuclease of Werner Syndrome Protein Journal of Biological Chemistry. 276: 44677-44687. PMID 11572872 DOI: 10.1074/jbc.M107548200  1
2000 Opresko PL, Shiman R, Eckert KA. Hydrophobic interactions in the hinge domain of DNA polymerase beta are important but not sufficient for maintaining fidelity of DNA synthesis. Biochemistry. 39: 11399-407. PMID 10985785 DOI: 10.1021/bi000698t  1
1999 Eckert KA, Opresko PL. DNA polymerase mutagenic bypass and proofreading of endogenous DNA lesions. Mutation Research. 424: 221-36. PMID 10064863 DOI: 10.1016/S0027-5107(99)00021-4  1
1998 Opresko PL, Sweasy JB, Eckert KA. The mutator form of polymerase beta with amino acid substitution at tyrosine 265 in the hinge region displays an increase in both base substitution and frame shift errors. Biochemistry. 37: 2111-9. PMID 9485358 DOI: 10.1021/bi9722711  1
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