Justin Radolf - Publications

Affiliations: 
University of Connecticut, Storrs, CT, United States 
Area:
Biochemistry, Microbiology Biology

70 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Luthra A, Montezuma-Rusca JM, La Vake CJ, LeDoyt M, Delgado KN, Davenport TC, Fiel-Gan M, Caimano MJ, Radolf JD, Hawley KL. Evidence that immunization with TP0751, a bipartite Treponema pallidum lipoprotein with an intrinsically disordered region and lipocalin fold, fails to protect in the rabbit model of experimental syphilis. Plos Pathogens. 16: e1008871. PMID 32936831 DOI: 10.1371/journal.ppat.1008871  0.311
2019 Hawley K, Luthra A, Vake CL, Ledoyt M, Chen W, Heping Z, Yang B, Juliano JJ, Parr JB, Radolf J, Salazar J, Camaino M. O01.2 Genetic, structural, and surface antigenic variation of treponema pallidum’s OMPeome: steps towards a global syphilis vaccine Sexually Transmitted Infections. 95. DOI: 10.1136/Sextrans-2019-Sti.105  0.315
2017 Radolf JD, Kumar S. The Treponema pallidum Outer Membrane. Current Topics in Microbiology and Immunology. PMID 28849315 DOI: 10.1007/82_2017_44  0.383
2017 Grove AP, Liveris D, Iyer R, Petzke M, Rudman J, Caimano MJ, Radolf JD, Schwartz I. Two Distinct Mechanisms Govern RpoS-Mediated Repression of Tick-Phase Genes during Mammalian Host Adaptation by Borrelia burgdorferi, the Lyme Disease Spirochete. Mbio. 8. PMID 28830947 DOI: 10.1128/Mbio.01204-17  0.314
2017 Radolf J, Kumar S, Smajs D, Dey A, Anand A, Ledoyt M, Karanian C, Cruz A, Ramirez L, Caimano M, Salazar J. LB1.1 Insights into the evolution of syphilis spirochetes within at-risk populations: sequence variation of outer membrane protein β-barrel domains in clinical samples Sexually Transmitted Infections. 93. DOI: 10.1136/Sextrans-2017-053264.102  0.322
2016 Kenedy MR, Scott EJ, Shrestha B, Anand A, Iqbal H, Radolf JD, Dyer DW, Akins DR. Consensus computational network analysis for identifying candidate outer membrane proteins from Borrelia spirochetes. Bmc Microbiology. 16: 141. PMID 27400788 DOI: 10.1186/S12866-016-0762-Z  0.779
2015 Luthra A, Anand A, Radolf JD. Treponema pallidum in Gel Microdroplets: A Method for Topological Analysis of BamA (TP0326) and Localization of Rare Outer Membrane Proteins. Methods in Molecular Biology (Clifton, N.J.). 1329: 67-75. PMID 26427677 DOI: 10.1007/978-1-4939-2871-2_6  0.314
2015 Caimano MJ, Dunham-Ems S, Allard AM, Cassera MB, Kenedy M, Radolf JD. Cyclic di-GMP modulates gene expression in Lyme disease spirochetes at the tick-mammal interface to promote spirochete survival during the blood meal and tick-to-mammal transmission. Infection and Immunity. 83: 3043-60. PMID 25987708 DOI: 10.1128/Iai.00315-15  0.767
2015 Iyer R, Caimano MJ, Luthra A, Axline D, Corona A, Iacobas DA, Radolf JD, Schwartz I. Stage-specific global alterations in the transcriptomes of Lyme disease spirochetes during tick feeding and following mammalian host adaptation. Molecular Microbiology. 95: 509-38. PMID 25425211 DOI: 10.1111/Mmi.12882  0.342
2014 Kenedy MR, Luthra A, Anand A, Dunn JP, Radolf JD, Akins DR. Structural modeling and physicochemical characterization provide evidence that P66 forms a β-barrel in the Borrelia burgdorferi outer membrane. Journal of Bacteriology. 196: 859-72. PMID 24317399 DOI: 10.1128/Jb.01236-13  0.779
2012 Anand A, Luthra A, Dunham-Ems S, Caimano MJ, Karanian C, LeDoyt M, Cruz AR, Salazar JC, Radolf JD. TprC/D (Tp0117/131), a trimeric, pore-forming rare outer membrane protein of Treponema pallidum, has a bipartite domain structure. Journal of Bacteriology. 194: 2321-33. PMID 22389487 DOI: 10.1128/Jb.00101-12  0.329
2011 Luthra A, Zhu G, Desrosiers DC, Eggers CH, Mulay V, Anand A, McArthur FA, Romano FB, Caimano MJ, Heuck AP, Malkowski MG, Radolf JD. The transition from closed to open conformation of Treponema pallidum outer membrane-associated lipoprotein TP0453 involves membrane sensing and integration by two amphipathic helices. The Journal of Biological Chemistry. 286: 41656-68. PMID 21965687 DOI: 10.1074/Jbc.M111.305284  0.759
2011 Eggers CH, Caimano MJ, Malizia RA, Kariu T, Cusack B, Desrosiers DC, Hazlett KR, Claiborne A, Pal U, Radolf JD. The coenzyme A disulphide reductase of Borrelia burgdorferi is important for rapid growth throughout the enzootic cycle and essential for infection of the mammalian host. Molecular Microbiology. 82: 679-97. PMID 21923763 DOI: 10.1111/J.1365-2958.2011.07845.X  0.771
2011 Pappas CJ, Iyer R, Petzke MM, Caimano MJ, Radolf JD, Schwartz I. Borrelia burgdorferi requires glycerol for maximum fitness during the tick phase of the enzootic cycle. Plos Pathogens. 7: e1002102. PMID 21750672 DOI: 10.1371/Journal.Ppat.1002102  0.327
2011 Caimano MJ, Kenedy MR, Kairu T, Desrosiers DC, Harman M, Dunham-Ems S, Akins DR, Pal U, Radolf JD. The hybrid histidine kinase Hk1 is part of a two-component system that is essential for survival of Borrelia burgdorferi in feeding Ixodes scapularis ticks. Infection and Immunity. 79: 3117-30. PMID 21606185 DOI: 10.1128/Iai.05136-11  0.744
2011 Desrosiers DC, Anand A, Luthra A, Dunham-Ems SM, LeDoyt M, Cummings MA, Eshghi A, Cameron CE, Cruz AR, Salazar JC, Caimano MJ, Radolf JD. TP0326, a Treponema pallidum β-barrel assembly machinery A (BamA) orthologue and rare outer membrane protein. Molecular Microbiology. 80: 1496-515. PMID 21488980 DOI: 10.1111/J.1365-2958.2011.07662.X  0.767
2010 Cox DL, Luthra A, Dunham-Ems S, Desrosiers DC, Salazar JC, Caimano MJ, Radolf JD. Surface immunolabeling and consensus computational framework to identify candidate rare outer membrane proteins of Treponema pallidum. Infection and Immunity. 78: 5178-94. PMID 20876295 DOI: 10.1128/Iai.00834-10  0.763
2010 Desrosiers DC, Bearden SW, Mier I, Abney J, Paulley JT, Fetherston JD, Salazar JC, Radolf JD, Perry RD. Znu is the predominant zinc importer in Yersinia pestis during in vitro growth but is not essential for virulence. Infection and Immunity. 78: 5163-77. PMID 20855510 DOI: 10.1128/Iai.00732-10  0.737
2010 Parsonage D, Desrosiers DC, Hazlett KR, Sun Y, Nelson KJ, Cox DL, Radolf JD, Poole LB. Broad specificity AhpC-like peroxiredoxin and its thioredoxin reductant in the sparse antioxidant defense system of Treponema pallidum. Proceedings of the National Academy of Sciences of the United States of America. 107: 6240-5. PMID 20304799 DOI: 10.1073/Pnas.0910057107  0.756
2010 Earnhart CG, Leblanc DV, Alix KE, Desrosiers DC, Radolf JD, Marconi RT. Identification of residues within ligand-binding domain 1 (LBD1) of the Borrelia burgdorferi OspC protein required for function in the mammalian environment. Molecular Microbiology. 76: 393-408. PMID 20199597 DOI: 10.1111/J.1365-2958.2010.07103.X  0.74
2009 Izard J, Renken C, Hsieh CE, Desrosiers DC, Dunham-Ems S, La Vake C, Gebhardt LL, Limberger RJ, Cox DL, Marko M, Radolf JD. Cryo-electron tomography elucidates the molecular architecture of Treponema pallidum, the syphilis spirochete. Journal of Bacteriology. 191: 7566-80. PMID 19820083 DOI: 10.1128/Jb.01031-09  0.756
2009 Radolf JD, Desrosiers DC. Treponema pallidum, the stealth pathogen, changes, but how? Molecular Microbiology. 72: 1081-6. PMID 19432802 DOI: 10.1111/J.1365-2958.2009.06711.X  0.764
2009 Mulay VB, Caimano MJ, Iyer R, Dunham-Ems S, Liveris D, Petzke MM, Schwartz I, Radolf JD. Borrelia burgdorferi bba74 is expressed exclusively during tick feeding and is regulated by both arthropod- and mammalian host-specific signals. Journal of Bacteriology. 191: 2783-94. PMID 19218390 DOI: 10.1128/Jb.01802-08  0.364
2007 Desrosiers DC, Sun YC, Zaidi AA, Eggers CH, Cox DL, Radolf JD. The general transition metal (Tro) and Zn2+ (Znu) transporters in Treponema pallidum: analysis of metal specificities and expression profiles. Molecular Microbiology. 65: 137-52. PMID 17581125 DOI: 10.1111/J.1365-2958.2007.05771.X  0.733
2007 Mulay V, Caimano MJ, Liveris D, Desrosiers DC, Radolf JD, Schwartz I. Borrelia burgdorferi BBA74, a periplasmic protein associated with the outer membrane, lacks porin-like properties. Journal of Bacteriology. 189: 2063-8. PMID 17189354 DOI: 10.1128/Jb.01239-06  0.771
2007 Li X, Pal U, Ramamoorthi N, Liu X, Desrosiers DC, Eggers CH, Anderson JF, Radolf JD, Fikrig E. The Lyme disease agent Borrelia burgdorferi requires BB0690, a Dps homologue, to persist within ticks. Molecular Microbiology. 63: 694-710. PMID 17181780 DOI: 10.1111/J.1365-2958.2006.05550.X  0.73
2005 Hazlett KR, Cox DL, Decaffmeyer M, Bennett MP, Desrosiers DC, La Vake CJ, La Vake ME, Bourell KW, Robinson EJ, Brasseur R, Radolf JD. TP0453, a concealed outer membrane protein of Treponema pallidum, enhances membrane permeability. Journal of Bacteriology. 187: 6499-508. PMID 16159783 DOI: 10.1128/Jb.187.18.6499-6508.2005  0.769
2004 Caimano MJ, Eggers CH, Hazlett KR, Radolf JD. RpoS is not central to the general stress response in Borrelia burgdorferi but does control expression of one or more essential virulence determinants. Infection and Immunity. 72: 6433-45. PMID 15501774 DOI: 10.1128/IAI.72.11.6433-6445.2004  0.312
2003 Ojaimi C, Brooks C, Casjens S, Rosa P, Elias A, Barbour A, Jasinskas A, Benach J, Katona L, Radolf J, Caimano M, Skare J, Swingle K, Akins D, Schwartz I. Profiling of temperature-induced changes in Borrelia burgdorferi gene expression by using whole genome arrays. Infection and Immunity. 71: 1689-705. PMID 12654782 DOI: 10.1128/Iai.71.4.1689-1705.2003  0.774
2002 Ojaimi C, Brooks C, Akins D, Casjens S, Rosa P, Elias A, Barbour A, Jasinskas A, Benach J, Katonah L, Radolf J, Caimano M, Skare J, Swingle K, Sims S, et al. Borrelia burgdorferi gene expression profiling with membrane-based arrays. Methods in Enzymology. 358: 165-77. PMID 12474386 DOI: 10.1016/S0076-6879(02)58088-5  0.778
2002 Roberts DM, Caimano M, McDowell J, Theisen M, Holm A, Orff E, Nelson D, Wikel S, Radolf J, Marconi RT. Environmental regulation and differential production of members of the Bdr protein family of Borrelia burgdorferi. Infection and Immunity. 70: 7033-41. PMID 12438383 DOI: 10.1128/Iai.70.12.7033-7041.2002  0.377
2002 Elias AF, Stewart PE, Grimm D, Caimano MJ, Eggers CH, Tilly K, Bono JL, Akins DR, Radolf JD, Schwan TG, Rosa P. Clonal polymorphism of Borrelia burgdorferi strain B31 MI: implications for mutagenesis in an infectious strain background. Infection and Immunity. 70: 2139-50. PMID 11895980 DOI: 10.1128/Iai.70.4.2139-2150.2002  0.574
2001 Ryan R, Krause PJ, Radolf J, Freeman K, Spielman A, Lenz R, Levin A. Diagnosis of babesiosis using an immunoblot serologic test Clinical and Diagnostic Laboratory Immunology. 8: 1177-1180. PMID 11687460 DOI: 10.1128/Cdli.8.6.1177-1180.2001  0.328
2001 Hefty PS, Jolliff SE, Caimano MJ, Wikel SK, Radolf JD, Akins DR. Regulation of OspE-related, OspF-related, and Elp lipoproteins of Borrelia burgdorferi strain 297 by mammalian host-specific signals. Infection and Immunity. 69: 3618-27. PMID 11349022 DOI: 10.1128/IAI.69.6.3618-3627.2001  0.789
2001 Hazlett KRO, Sellati TJ, Nguyen TT, Cox DL, Clawson ML, Caimano MJ, Radolf JD. The TprK protein of Treponema pallidum is periplasmic and is not a target of opsonic antibody or protective immunity Journal of Experimental Medicine. 193: 1015-1026. PMID 11342586 DOI: 10.1084/jem.193.9.1015  0.32
2000 Caimano MJ, Yang X, Popova TG, Clawson ML, Akins DR, Norgard MV, Radolf JD. Molecular and evolutionary characterization of the cp32/18 family of supercoiled plasmids in Borrelia burgdorferi 297 Infection and Immunity. 68: 1574-1586. PMID 10678977 DOI: 10.1128/IAI.68.3.1574-1586.2000  0.588
1999 Yang X, Popova TG, Hagman KE, Wikel SK, Schoeler GB, Caimano MJ, Radolf JD, Norgard MV. Identification, characterization, and expression of three new members of the Borrelia burgdorferi Mlp (2.9) lipoprotein gene family Infection and Immunity. 67: 6008-6018. PMID 10531261  0.318
1999 Caimano MJ, Bourell KW, Bannister TD, Cox DL, Radolf JD. The Treponema denticola major sheath protein is predominantly periplasmic and has only limited surface exposure Infection and Immunity. 67: 4072-4083. PMID 10417176  0.32
1999 Shevchenko DV, Sellati TJ, Cox DL, Shevchenko OV, Robinson EJ, Radolf JD. Membrane topology and cellular location of the Treponema pallidum glycerophosphodiester phosphodiesterase (GlpQ) ortholog Infection and Immunity. 67: 2266-2276. PMID 10225883  0.325
1999 Akins DR, Caimano MJ, Yang X, Cerna F, Norgard MV, Radolf JD. Molecular and evolutionary analysis of Borrelia burgdorferi 297 circular plasmid-encoded lipoproteins with OspE- and OspF-like leader peptides Infection and Immunity. 67: 1526-1532. PMID 10024606  0.559
1998 Hagman KE, Lahdenne P, Popova TG, Porcella SF, Akins DR, Radolf JD, Norgard MV. Decorin-binding protein of Borrelia burgdorferi is encoded within a two- gene operon and is protective in the murine model of Lyme borreliosis Infection and Immunity. 66: 2674-2683. PMID 9596733  0.627
1998 Akins DR, Bourell KW, Caimano MJ, Norgard MV, Radolf JD. A new animal model for studying Lyme disease spirochetes in a mammalian host-adapted state Journal of Clinical Investigation. 101: 2240-2250. PMID 9593780  0.609
1997 Hardham JM, Stamm LV, Porcella SF, Frye JG, Barnes NY, Howell JK, Mueller SL, Radolf JD, Weinstock GM, Norris SJ. Identification and transcriptional analysis of a Treponema pallidum operon encoding a putative ABC transport system, an iron-activated repressor protein homolog, and a glycolytic pathway enzyme homolog. Gene. 197: 47-64. PMID 9332349 DOI: 10.1016/S0378-1119(97)00234-5  0.324
1997 Shevchenko DV, Akins DR, Robinson EJ, Li M, Shevchenko OV, Radolf JD. Identification of homologs for thioredoxin, peptidyl prolyl cis-trans isomerase, and glycerophosphodiester phosphodiesterase in outer membrane fractions from Treponema pallidum, the syphilis spirochete Infection and Immunity. 65: 4179-4189. PMID 9317025  0.626
1997 Akins DR, Robinson E, Shevchenko D, Elkins C, Cox DL, Radolf JD. Tromp1, a putative rare outer membrane protein, is anchored by an uncleaved signal sequence to the Treponema pallidum cytoplasmic membrane Journal of Bacteriology. 179: 5076-5086. PMID 9260949  0.619
1997 Shevchenko DV, Akins DR, Robinson E, Li M, Popova TG, Cox DL, Radolf JD. Molecular characterization and cellular localization of TpLRR, a processed leucine-rich repeat protein of Treponema pallidum, the syphilis spirochete Journal of Bacteriology. 179: 3188-3195. PMID 9150213  0.612
1997 Klesney-Tait J, Hiltke TJ, Maciver I, Spinola SM, Radolf JD, Hansen EJ. The major outer membrane protein of Haemophilus ducreyi consists of two OmpA homologs Journal of Bacteriology. 179: 1764-1773. PMID 9045839  0.345
1997 Lahdenne P, Porcella SF, Hagman KE, Akins DR, Popova TG, Cox DL, Katona LI, Radolf JD, Norgard MV. Molecular characterization of a 6.6-kilodalton Borrelia burgdorferi outer membrane-associated lipoprotein (lp6.6) which appears to be downregulated during mammalian infection. Infection and Immunity. 65: 412-21. PMID 9009290  0.623
1996 Cox DL, Akins DR, Bourell KW, Lahdenne P, Norgard MV, Radolf JD. Limited surface exposure of Borrelia burgdorferi outer surface lipoproteins Proceedings of the National Academy of Sciences of the United States of America. 93: 7973-7978. PMID 8755587 DOI: 10.1073/pnas.93.15.7973  0.545
1996 Norgard MV, Arndt LL, Akins DR, Curetty LL, Harrich DA, Radolf JD. Activation of human monocytic cells by Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides proceeds via a pathway distinct from that of lipopolysaccharide but involves the transcriptional activator NF-κB Infection and Immunity. 64: 3845-3852. PMID 8751937  0.519
1996 Porcella SF, Popova TG, Akins DR, Li M, Radolf JD, Norgard MV. Borrelia burgdorferi supercoiled plasmids encode multicopy tandem open reading frames and a lipoprotein gene family Journal of Bacteriology. 178: 3293-3307. PMID 8655511  0.583
1996 Stevens MK, Porcella S, Klesney-Tait J, Lumbley S, Thomas SE, Norgard MV, Radolf JD, Hansen EJ. A hemoglobin-binding outer membrane protein is involved in virulence expression by Haemophilus ducreyi in an animal model Infection and Immunity. 64: 1724-1735. PMID 8613384  0.333
1996 Stevens MK, Porcella S, Klesney-Tait J, Lumbley S, Thomas SE, Norgard MV, Radolf JD, Hansen EJ. A hemoglobin-binding outer membrane protein is involved in virulence expression by Haemophilus ducreyi in an animal model. Infection and Immunity. 64: 1724-1735. DOI: 10.1128/iai.64.5.1724-1735.1996  0.311
1995 Norgard MV, Baker SI, Radolf JD. Chemiluminescent analysis of Borrelia burgdorferi penicillin-binding proteins using ampicillin conjugated to digoxigenin Microbial Pathogenesis. 19: 257-272. PMID 8825913 DOI: 10.1016/S0882-4010(95)90308-9  0.319
1995 Akins DR, Porcella SF, Popova TG, Shevchenko D, Baker SI, Li M, Norgard MV, Radolf JD. Evidence for in vivo but not in vitro expression of a Borrelia burgdorferi outer surface protein F (OspF) homologue Molecular Microbiology. 18: 507-520. PMID 8748034  0.61
1995 Radolf JD. Treponema pallidum and the quest for outer membrane proteins Molecular Microbiology. 16: 1067-1073. PMID 8577243 DOI: 10.1111/j.1365-2958.1995.tb02332.x  0.338
1995 Radolf JD, Arndt LL, Akins DR, Curetty LL, Levi ME, Shen Y, Davis LS, Norgard MV. Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides activate monocytes/macrophages Journal of Immunology. 154: 2866-2877. PMID 7876555  0.531
1995 Radolf JD, Goldberg MS, Bourell K, Baker SI, Jones JD, Norgard MV. Characterization of outer membranes isolated from Borrelia burgdorferi, the Lyme disease spirochete Infection and Immunity. 63: 2154-2163. PMID 7768594  0.335
1995 Cox DL, Akins DR, Porcella SF, Norgard MV, Radolf JD. Treponema pallidum in gel microdroplets: A novel strategy for investigation of treponemal molecular architecture Molecular Microbiology. 15: 1151-1164. PMID 7623668  0.604
1995 Radolf JD, Robinson EJ, Bourell KW, Akins DR, Porcella SF, Weigel LM, Jones JD, Norgard MV. Characterization of outer membranes isolated from Treponema pallidum, the syphilis spirochete Infection and Immunity. 63: 4244-4252. PMID 7591054  0.588
1994 Radolf JD, Bourell KW, Akins DR, Brusca JS, Norgard MV. Analysis of Borrelia burgdorferi membrane architecture by freeze-fracture electron microscopy Journal of Bacteriology. 176: 21-31. PMID 8282698  0.572
1994 Becker PS, Akins DR, Radolf JD, Norgard MV. Similarity between the 38-kilodalton lipoprotein of Treponema pallidum and the glucose/galactose-binding (MglB) protein of Escherichia coli Infection and Immunity. 62: 1381-1391. PMID 8132345  0.608
1994 Weigel LM, Radolf JD, Norgard MV. The 47-kDa major lipoprotein immunogen of Treponema pallidum is a penicillin-binding protein with carboxypeptidase activity Proceedings of the National Academy of Sciences of the United States of America. 91: 11611-11615. PMID 7972112 DOI: 10.1073/pnas.91.24.11611  0.386
1993 Akins DR, Purcell BK, Mitra MM, Norgard MV, Radolf JD. Lipid modification of the 17-kilodalton membrane immunogen of Treponema pallidum determines macrophage activation as well as amphiphilicity. Infection and Immunity. 61: 1202-10. PMID 8454324  0.594
1992 Cox DL, Chang P, McDowall AW, Radolf JD. The outer membrane, not a coat of host proteins, limits antigenicity of virulent Treponema pallidum Infection and Immunity. 60: 1076-1083. PMID 1541522  0.347
1991 Brusca JS, McDowall AW, Norgard MV, Radolf JD. Localization of outer surface proteins A and B in both the outer membrane and intracellular compartments of Borrelia burgdorferi Journal of Bacteriology. 173: 8004-8008. PMID 1744059  0.317
1990 Brandt ME, Riley BS, Radolf JD, Norgard MV. Immunogenic integral membrane proteins of Borrelia burgdorferi are lipoproteins Infection and Immunity. 58: 983-991. PMID 2318538  0.308
1989 Purcell BK, Chamberlain NR, Goldberg MS, Andrews LP, Robinson EJ, Norgard MV, Radolf JD. Molecular cloning and characterization of the 15-kilodalton major immunogen of Treponema pallidum. Infection and Immunity. 57: 3708-14. PMID 2680978  0.308
1989 Swancutt MA, Riley BS, Radolf JD, Norgard MV. Molecular characterization of the pathogen-specific, 34-kilodalton membrane immunogen of Treponema pallidum Infection and Immunity. 57: 3314-3323. PMID 2680970  0.332
1988 Chamberlain NR, Radolf JD, Pei-Ling Hsu, Sell S, Norgard MV. Genetic and physicochemical characterization of the recombinant DNA-derived 47-kilodalton surface immunogen of Treponema pallidum subsp. pallidum Infection and Immunity. 56: 71-78. PMID 3275588  0.317
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