☰

Joann B. Sweasy - Publications

Affiliations: 
Yale University, New Haven, CT 
Area:
Biochemistry
Tree Info Similar researchers PubMed Report error

134 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Sweasy JB, Hanawalt PC. Evelyn M. Witkin (1921-2023). Science (New York, N.Y.). 381: 1052. PMID 37676948 DOI: 10.1126/science.adk1028  0.338
2023 Hua AB, Sweasy JB. Functional Roles and Cancer Variants of the Bifunctional Glycosylase NEIL2. Environmental and Molecular Mutagenesis. PMID 37310399 DOI: 10.1002/em.22555  0.464
2023 Sawyer DL, Sweasy JB. DNA Polymerase β in the Context of Cancer. Critical Reviews in Oncogenesis. 27: 17-33. PMID 36734870 DOI: 10.1615/CritRevOncog.2022043477  0.475
2022 Kant M, Quintana V, Coskun E, Jaruga P, Lloyd RS, Sweasy JB, Dizdaroglu M. Polymorphic variant Asp239Tyr of human DNA glycosylase NTHL1 is inactive for removal of a variety of oxidatively-induced DNA base lesions from genomic DNA. Dna Repair. 117: 103372. PMID 35870279 DOI: 10.1016/j.dnarep.2022.103372  0.464
2021 Marsden CG, Das L, Nottoli TP, Kathe SD, Doublié S, Wallace SS, Sweasy JB. Mouse Embryonic Fibroblasts Isolated From Nthl1 D227Y Knockin Mice Exhibit Defective DNA Repair and Increased Genome Instability. Dna Repair. 109: 103247. PMID 34826736 DOI: 10.1016/j.dnarep.2021.103247  0.484
2021 Paluri SL, Burak M, Senejani AG, Levinson M, Rahim T, Clairmont K, Kashgarian M, Alvarado-Cruz I, Meas R, Cardó-Vila M, Zeiss C, Maher S, Bothwell ALM, Coskun E, Kant M, ... ... Sweasy JB, et al. DNA glycosylase deficiency leads to decreased severity of lupus in the Polb-Y265C mouse model. Dna Repair. 105: 103152. PMID 34186496 DOI: 10.1016/j.dnarep.2021.103152  0.392
2020 Das L, Quintana VG, Sweasy JB. NTHL1 in genomic integrity, aging and cancer. Dna Repair. 93: 102920. PMID 33087284 DOI: 10.1016/j.dnarep.2020.102920  0.439
2020 Marsden CG, Jaruga P, Coskun E, Maher RL, Pederson DS, Dizdaroglu M, Sweasy JB. Expression of a germline variant in the N-terminal domain of the human DNA glycosylase NTHL1 induces cellular transformation without impairing enzymatic function or substrate specificity. Oncotarget. 11: 2262-2272. PMID 32595826 DOI: 10.18632/Oncotarget.27548  0.488
2020 Fijen C, Mahmoud MM, Kronenberg M, Kaup R, Fontana M, Towle-Weicksel JB, Sweasy JB, Hohlbein J. Using single-molecule FRET to probe the nucleotide-dependent conformational landscape of Pol β-DNA complexes. The Journal of Biological Chemistry. PMID 32385112 DOI: 10.1074/Jbc.Ra120.013049  0.526
2020 Sweasy JB. DNA polymerase κ: Friend or foe? Science Signaling. 13. PMID 32345726 DOI: 10.1126/scisignal.abb2934  0.363
2020 Batra VK, Alnajjar KS, Sweasy JB, McKenna CE, Goodman MF, Wilson SH. Revealing an internal stabilization deficiency in the DNA polymerase β K289M cancer variant through combined use of chemical biology and X-ray crystallography. Biochemistry. PMID 31999437 DOI: 10.1021/Acs.Biochem.9B01072  0.429
2019 Smith MR, Alnajjar KS, Hoitsma NM, Sweasy JB, Freudenthal BD. Molecular and structural characterization of oxidized ribonucleotide insertion into DNA by human DNA polymerase β. The Journal of Biological Chemistry. PMID 31892517 DOI: 10.1074/Jbc.Ra119.011569  0.375
2019 Alvarado-Cruz I, Meas R, Paluri SLA, Carufe KEW, Khan M, Sweasy JB. The double-edged sword of cancer mutations: exploiting neoepitopes for the fight against cancer. Mutagenesis. PMID 31880305 DOI: 10.1093/Mutage/Gez049  0.447
2019 Hanawalt P, Sweasy J. Mechanistic understanding of cellular responses to genomic stress. Environmental and Molecular Mutagenesis. 61: 25-33. PMID 31793074 DOI: 10.1002/Em.22349  0.404
2019 Alnajjar KS, Krylov IS, Negahbani A, Haratipour P, Kashemirov BA, Huang J, Mahmoud M, McKenna CE, Goodman MF, Sweasy JB. A pre-catalytic non-covalent step governs DNA polymerase β fidelity. Nucleic Acids Research. PMID 31732732 DOI: 10.1093/Nar/Gkz1076  0.458
2019 Duro MVV, Alnajjar KS, Sweasy JB, Kashemirov BA, McKenna CE. Synthesis of -Formylphenylphosphonic Acids as Covalent Probes of Active Site Lysines. Phosphorus, Sulfur, and Silicon and the Related Elements. 194: 313-314. PMID 31213749 DOI: 10.1080/10426507.2018.1539996  0.428
2019 Alnajjar KS, Sweasy JB. A new perspective on oxidation of DNA repair proteins and cancer. Dna Repair. 76: 60-69. PMID 30818170 DOI: 10.1016/J.Dnarep.2019.02.006  0.449
2019 Sweasy JB, Meas R, Nititham J, Taylor K, Criswell L. 203 A mismatch repair genetic variant is linked to the development of lupus Lupus Science & Medicine. 6. DOI: 10.1136/Lupus-2019-Lsm.203  0.511
2019 Eckenroth BE, Prakash A, Carroll BL, Sweasy JB, Doublié S. Structural and cellular analyses of cancer-associated mutations in DNA repair enzymes Acta Crystallographica Section a Foundations and Advances. 75: a327-a327. DOI: 10.1107/S0108767319096818  0.545
2018 Liptak C, Mahmoud MM, Eckenroth BE, Moreno MV, East K, Alnajjar KS, Huang J, Towle-Weicksel JB, Doublié S, Loria JP, Sweasy JB. I260Q DNA polymerase β highlights precatalytic conformational rearrangements critical for fidelity. Nucleic Acids Research. PMID 30239932 DOI: 10.1093/Nar/Gky825  0.517
2018 Huang J, Alnajjar KS, Mahmoud MM, Eckenroth BE, Doublie S, Sweasy J. The nature of the DNA substrate influences pre-catalytic conformational changes of DNA polymerase . The Journal of Biological Chemistry. PMID 30068550 DOI: 10.1074/Jbc.Ra118.004564  0.554
2018 Oertell K, Kashemirov BA, Negahbani A, Minard C, Haratipour P, Alnajjar KS, Sweasy JB, Batra VK, Beard WA, Wilson SH, McKenna CE, Goodman MF. Probing DNA base-dependent leaving group kinetic effects on the DNA polymerase transition state. Biochemistry. PMID 29889506 DOI: 10.1021/Acs.Biochem.8B00417  0.419
2018 Landry K, Seward D, Dragon J, McKinnon W, Colello LS, Sweasy J, Wallace S, Cuke M, Wood M. Investigation of discordant sibling pairs from hereditary breast cancer (HBC) families. Journal of Clinical Oncology. 36: 1538-1538. DOI: 10.1200/Jco.2018.36.15_Suppl.1538  0.351
2017 Ray S, Breuer G, DeVeaux M, Zelterman D, Bindra R, Sweasy JB. DNA polymerase beta participates in DNA End-joining. Nucleic Acids Research. PMID 29161447 DOI: 10.1093/Nar/Gkx1147  0.607
2017 Galick HA, Marsden CG, Kathe S, Dragon JA, Volk L, Nemec AA, Wallace SS, Prakash A, Doublié S, Sweasy JB. The NEIL1 G83D germline DNA glycosylase variant induces genomic instability and cellular transformation. Oncotarget. 8: 85883-85895. PMID 29156764 DOI: 10.18632/Oncotarget.20716  0.498
2017 Mahmoud MM, Schechter A, Alnajjar KS, Huang J, Towle-Weicksel JB, Eckenroth BE, Doublié S, Sweasy JB. Defective Nucleotide Release by DNA Polymerase Beta Mutator Variant E288K is the Basis of Its Low Fidelity. Biochemistry. PMID 28945359 DOI: 10.1021/Acs.Biochem.7B00869  0.598
2017 Alnajjar KS, Negahbani A, Nakhjiri M, Krylov I, Kashemirov BA, McKenna CE, Goodman MF, Sweasy JB. DNA polymerase Beta Cancer-Associated Variant I260M Exhibits Nonspecific Selectivity Towards β-γ Bridging Group of the Incoming dNTP. Biochemistry. PMID 28862868 DOI: 10.1021/Acs.Biochem.7B00713  0.471
2017 Maher RL, Marsden CG, Averill AM, Wallace SS, Sweasy JB, Pederson DS. Human cells contain a factor that facilitates the DNA glycosylase-mediated excision of oxidized bases from occluded sites in nucleosomes. Dna Repair. 57: 91-97. PMID 28709015 DOI: 10.1016/J.Dnarep.2017.06.029  0.414
2017 Marsden CG, Dragon JA, Wallace SS, Sweasy JB. Base Excision Repair Variants in Cancer. Methods in Enzymology. 591: 119-157. PMID 28645367 DOI: 10.1016/Bs.Mie.2017.03.003  0.504
2017 Meas R, Burak MJ, Sweasy JB. DNA repair and systemic lupus erythematosus. Dna Repair. PMID 28623091 DOI: 10.1016/J.Dnarep.2017.06.020  0.485
2017 Eckenroth BE, Towle-Weicksel JB, Nemec AA, Murphy DL, Sweasy JB, Doublié S. Remote mutations induce functional changes in active site residues of human DNA polymerase beta. Biochemistry. PMID 28402631 DOI: 10.1021/Acs.Biochem.6B01287  0.507
2017 Alnajjar KS, Garcia-Barboza B, Negahbani A, Nakhjiri M, Kashemirov BA, McKenna CE, Goodman MF, Sweasy JB. A Change in the Rate-Determining Step of Polymerization by the K289M DNA Polymerase Beta Cancer-Associated Variant. Biochemistry. PMID 28326765 DOI: 10.1021/Acs.Biochem.6B01230  0.517
2017 Nemec AA, Abriola L, Merkel JS, deStanchina E, DeVeaux M, Zelterman D, Glazer PM, Sweasy JB. DNA polymerase beta germline variant confers cellular response to cisplatin therapy. Molecular Cancer Research : McR. PMID 28074003 DOI: 10.1158/1541-7786.Mcr-16-0227-T  0.536
2017 Ray S, DeVeaux M, Breuer G, Bindra R, Zelterman D, Sweasy J. Abstract 2492: DNA polymerase beta participates in DNA end-joining Cancer Research. 77: 2492-2492. DOI: 10.1158/1538-7445.Am2017-2492  0.61
2016 Nemec AA, Bush KB, Towle-Weicksel JB, Taylor BF, Schulz V, Weidhaas J, Tuck DP, Sweasy JB. Estrogen Drives Cellular Transformation and Mutagenesis in Cells Expressing the Breast Cancer-associated R438W DNA Polymerase Lambda Protein. Molecular Cancer Research : McR. PMID 27621267 DOI: 10.1158/1541-7786.Mcr-16-0209  0.462
2016 Marsden CG, Jensen RB, Zagelbaum J, Rothenberg E, Morrical SW, Wallace SS, Sweasy JB. The Tumor-Associated Variant RAD51 G151D Induces a Hyper-Recombination Phenotype. Plos Genetics. 12: e1006208. PMID 27513445 DOI: 10.1371/Journal.Pgen.1006208  0.55
2016 Sweasy JB, Galick H, Kathe S, Wallace S. Abstract 3590: A Neil1 DNA glycosylase germline variant induces genomic instability and cellular transformation Cancer Research. 76: 3590-3590. DOI: 10.1158/1538-7445.Am2016-3590  0.566
2015 Sweasy JB, Lieberman HB, Volkert M, George D. Evelyn Witkin and the coordinated response to DNA damage. Dna Repair. 35: 154-155. PMID 26529061 DOI: 10.1016/J.Dnarep.2015.10.005  0.468
2015 Rozacky J, Nemec AA, Sweasy JB, Kidane D. Gastric cancer associated variant of DNA polymerase beta (Leu22Pro) promotes DNA replication associated double strand breaks. Oncotarget. 6: 24474-87. PMID 26090616 DOI: 10.18632/Oncotarget.4426  0.613
2015 Sizova DV, Keh A, Taylor BF, Sweasy JB. The R280H X-ray cross-complementing 1 germline variant induces genomic instability and cellular transformation. Dna Repair. 31: 73-9. PMID 26011397 DOI: 10.1016/J.Dnarep.2015.05.005  0.521
2015 McVeigh TP, Jung SY, Kerin MJ, Salzman DW, Nallur S, Nemec AA, Dookwah M, Sadofsky J, Paranjape T, Kelly O, Chan E, Miller N, Sweeney KJ, Zelterman D, Sweasy J, et al. Estrogen withdrawal, increased breast cancer risk and the KRAS-variant. Cell Cycle (Georgetown, Tex.). 14: 2091-9. PMID 25961464 DOI: 10.1080/15384101.2015.1041694  0.322
2015 Sohl CD, Ray S, Sweasy JB. Pools and Pols: Mechanism of a mutator phenotype. Proceedings of the National Academy of Sciences of the United States of America. 112: 5864-5. PMID 25931524 DOI: 10.1073/Pnas.1505169112  0.56
2015 Lokanga RA, Senejani AG, Sweasy JB, Usdin K. Heterozygosity for a hypomorphic Polβ mutation reduces the expansion frequency in a mouse model of the Fragile X-related disorders. Plos Genetics. 11: e1005181. PMID 25886163 DOI: 10.1371/Journal.Pgen.1005181  0.362
2015 Chen J, Morrical MD, Donigan KA, Weidhaas JB, Sweasy JB, Averill AM, Tomczak JA, Morrical SW. Tumor-associated mutations in a conserved structural motif alter physical and biochemical properties of human RAD51 recombinase. Nucleic Acids Research. 43: 1098-111. PMID 25539919 DOI: 10.1093/Nar/Gku1337  0.827
2015 Weidhaas JB, McVeigh TP, Jung SY, Salzman D, Nallur S, Dookwah M, Nemec AA, Sadofsky J, Paranjape T, Kelly O, Chan E, Miller N, Sweeney KJ, Zelterman D, Sweasy J, et al. Estrogen withdrawal, breast cell transformation, and multiple breast cancer risk in women with the KRAS-variant. Journal of Clinical Oncology. 33: e12541-e12541. DOI: 10.1200/Jco.2015.33.15_Suppl.E12541  0.307
2015 Ji Y, Rounds T, Dragon J, Bond J, Wallace S, Sweasy J, Wood M. DNA repair landscape of discordant sibling pairs from hereditary breast cancer families. Journal of Clinical Oncology. 33: 1557-1557. DOI: 10.1200/Jco.2015.33.15_Suppl.1557  0.524
2015 Weidhaas JB, Mcveigh T, Pilarski R, Miller N, Sweasy J, Kerin M, Nallur S, Sadofsky J, Nemec A, Sweeney K, Daniel Z. Abstract P6-10-02: The KRAS-variant, multiple breast cancer risk, and estrogen withdrawal Cancer Research. 75. DOI: 10.1158/1538-7445.Sabcs14-P6-10-02  0.325
2015 Kidane D, Rozacky J, Sweasy JB. Abstract 3026: Gastric cancer associated variant of DNA polymerase Beta (Leu22Pro) induce genomic instability and cellular transformation Cancer Research. 75: 3026-3026. DOI: 10.1158/1538-7445.Am2015-3026  0.605
2014 Kidane D, Murphy DL, Sweasy JB. Accumulation of abasic sites induces genomic instability in normal human gastric epithelial cells during Helicobacter pylori infection. Oncogenesis. 3: e128. PMID 25417725 DOI: 10.1038/oncsis.2014.42  0.342
2014 Sjolund A, Nemec AA, Paquet N, Prakash A, Sung P, Doublié S, Sweasy JB. A germline polymorphism of thymine DNA glycosylase induces genomic instability and cellular transformation. Plos Genetics. 10: e1004753. PMID 25375110 DOI: 10.1371/Journal.Pgen.1004753  0.576
2014 Towle-Weicksel JB, Dalal S, Sohl CD, Doublie S, Anderson KS, Sweasy JB. Fluorescence resonance energy transfer studies of DNA polymerase β the critical role of fingers domain movements and a novel non-covalent step During nucleotide selection Journal of Biological Chemistry. 289: 16541-16550. PMID 24764311 DOI: 10.1074/Jbc.M114.561878  0.483
2014 Nemec AA, Murphy DL, Donigan KA, Sweasy JB. The S229L colon tumor-associated variant of DNA polymerase β induces cellular transformation as a result of decreased polymerization efficiency. The Journal of Biological Chemistry. 289: 13708-16. PMID 24668809 DOI: 10.1074/Jbc.M114.550400  0.841
2014 Eckenroth BE, Fleming AM, Sweasy JB, Burrows CJ, Doublié S. Crystal structure of DNA polymerase β with DNA containing the base lesion spiroiminodihydantoin in a templating position. Biochemistry. 53: 2075-7. PMID 24649945 DOI: 10.1021/Bi500270E  0.476
2014 Kidane D, Chae WJ, Czochor J, Eckert KA, Glazer PM, Bothwell AL, Sweasy JB. Interplay between DNA repair and inflammation, and the link to cancer. Critical Reviews in Biochemistry and Molecular Biology. 49: 116-39. PMID 24410153 DOI: 10.3109/10409238.2013.875514  0.525
2014 Senejani AG, Liu Y, Kidane D, Maher SE, Zeiss CJ, Park HJ, Kashgarian M, McNiff JM, Zelterman D, Bothwell AL, Sweasy JB. Mutation of POLB causes lupus in mice. Cell Reports. 6: 1-8. PMID 24388753 DOI: 10.1016/J.Celrep.2013.12.017  0.425
2014 Prakash A, Carroll BL, Sweasy JB, Wallace SS, Doublié S. Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: activity, structure, and the effect of editing. Dna Repair. 14: 17-26. PMID 24382305 DOI: 10.1016/J.Dnarep.2013.12.003  0.546
2014 Lamb KL, Liu Y, Ishiguro K, Kwon Y, Paquet N, Sartorelli AC, Sung P, Rockwell S, Sweasy JB. Tumor-associated mutations in O6-methylguanine DNA-methyltransferase (MGMT) reduce DNA repair functionality Molecular Carcinogenesis. 53: 201-210. PMID 23065697 DOI: 10.1002/Mc.21964  0.816
2013 Ray S, Menezes MR, Senejani A, Sweasy JB. Cellular roles of DNA polymerase beta. The Yale Journal of Biology and Medicine. 86: 463-9. PMID 24348210 DOI: 10.1371/Journal.  0.536
2013 Eckenroth BE, Towle-Weicksel JB, Sweasy JB, Doublié S. The E295K cancer variant of human polymerase β favors the mismatch conformational pathway during nucleotide selection. The Journal of Biological Chemistry. 288: 34850-60. PMID 24133209 DOI: 10.1074/Jbc.M113.510891  0.536
2013 Galick HA, Kathe S, Liu M, Robey-Bond S, Kidane D, Wallace SS, Sweasy JB. Germ-line variant of human NTH1 DNA glycosylase induces genomic instability and cellular transformation. Proceedings of the National Academy of Sciences of the United States of America. 110: 14314-9. PMID 23940330 DOI: 10.1073/Pnas.1306752110  0.552
2013 Gridley CL, Rangarajan S, Firbank S, Dalal S, Sweasy JB, Jaeger J. Structural changes in the hydrophobic hinge region adversely affect the activity and fidelity of the I260Q mutator DNA polymerase β. Biochemistry. 52: 4422-32. PMID 23651085 DOI: 10.1021/Bi301368F  0.518
2013 Sjolund AB, Senejani AG, Sweasy JB. MBD4 and TDG: multifaceted DNA glycosylases with ever expanding biological roles. Mutation Research. 743: 12-25. PMID 23195996 DOI: 10.1016/J.Mrfmmm.2012.11.001  0.564
2013 Kidane D, Murphy DL, Sweasy JB. Abstract LB-150: Carcinogenic Helicobacter pylori infection induces base excision repair intermediates to trigger homologous-dependent repair in human gastric epithelial cells. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-150  0.308
2013 Hansen JE, Chan G, Liu Y, Hegan DC, Dalal S, Dray E, Kwon Y, Xu Y, Xu X, Peterson-Roth E, Geiger E, Liu Y, Gera J, Sweasy JB, Sung P, et al. Abstract 4319: Lupus antibody-based cancer therapy. Cancer Research. 73: 4319-4319. DOI: 10.1158/1538-7445.Am2013-4319  0.479
2012 Yamtich J, Nemec AA, Keh A, Sweasy JB. A germline polymorphism of DNA polymerase beta induces genomic instability and cellular transformation. Plos Genetics. 8: e1003052. PMID 23144635 DOI: 10.1371/Journal.Pgen.1003052  0.819
2012 Hansen JE, Chan G, Liu Y, Hegan DC, Dalal S, Dray E, Kwon Y, Xu Y, Xu X, Peterson-Roth E, Geiger E, Liu Y, Gera J, Sweasy JB, Sung P, et al. Targeting cancer with a lupus autoantibody. Science Translational Medicine. 4: 157ra142. PMID 23100628 DOI: 10.1126/Scitranslmed.3004385  0.498
2012 Eckert KA, Sweasy JB. DNA polymerases and their role in genomic stability. Environmental and Molecular Mutagenesis. 53: 643-4. PMID 23055294 DOI: 10.1002/Em.21746  0.479
2012 Kidane D, Ayora S, Sweasy JB, Graumann PL, Alonso JC. The cell pole: the site of cross talk between the DNA uptake and genetic recombination machinery. Critical Reviews in Biochemistry and Molecular Biology. 47: 531-55. PMID 23046409 DOI: 10.3109/10409238.2012.729562  0.537
2012 Klvaňa M, Murphy DL, Jeřábek P, Goodman MF, Warshel A, Sweasy JB, Florián J. Catalytic effects of mutations of distant protein residues in human DNA polymerase β: theory and experiment. Biochemistry. 51: 8829-43. PMID 23013478 DOI: 10.1021/Bi300783T  0.458
2012 Menezes MR, Sweasy JB. Mouse models of DNA polymerases. Environmental and Molecular Mutagenesis. 53: 645-65. PMID 23001998 DOI: 10.1002/Em.21731  0.571
2012 Donigan KA, Tuck D, Schulz V, Sweasy JB. DNA polymerase β variant Ile260Met generates global gene expression changes related to cellular transformation. Mutagenesis. 27: 683-91. PMID 22914675 DOI: 10.1093/Mutage/Ges034  0.814
2012 Kidane D, Sweasy JB. Tipping the balance in the powerhouse of the cell to "protect" colorectal cancer. Plos Genetics. 8: e1002758. PMID 22685422 DOI: 10.1371/Journal.Pgen.1002758  0.44
2012 Li Y, Gridley CL, Jaeger J, Sweasy JB, Schlick T. Unfavorable electrostatic and steric interactions in DNA polymerase β E295K mutant interfere with the enzyme's pathway. Journal of the American Chemical Society. 134: 9999-10010. PMID 22651551 DOI: 10.1021/Ja300361R  0.442
2012 Murphy DL, Donigan KA, Jaeger J, Sweasy JB. The E288K colon tumor variant of DNA polymerase β is a sequence specific mutator. Biochemistry. 51: 5269-75. PMID 22650412 DOI: 10.1021/Bi3003583  0.845
2012 Donigan KA, Sun KW, Nemec AA, Murphy DL, Cong X, Northrup V, Zelterman D, Sweasy JB. Human POLB gene is mutated in high percentage of colorectal tumors. The Journal of Biological Chemistry. 287: 23830-9. PMID 22577134 DOI: 10.1074/Jbc.M111.324947  0.816
2012 Nemec AA, Donigan KA, Murphy DL, Jaeger J, Sweasy JB. Colon cancer-associated DNA polymerase β variant induces genomic instability and cellular transformation. The Journal of Biological Chemistry. 287: 23840-9. PMID 22573322 DOI: 10.1074/Jbc.M112.362111  0.831
2012 Senejani AG, Dalal S, Liu Y, Nottoli TP, McGrath JM, Clairmont CS, Sweasy JB. Y265C DNA polymerase beta knockin mice survive past birth and accumulate base excision repair intermediate substrates. Proceedings of the National Academy of Sciences of the United States of America. 109: 6632-7. PMID 22493258 DOI: 10.1073/Pnas.1200800109  0.561
2012 Berlow RB, Swain M, Dalal S, Sweasy JB, Loria JP. Substrate-dependent millisecond domain motions in DNA polymerase β. Journal of Molecular Biology. 419: 171-82. PMID 22446382 DOI: 10.1016/J.Jmb.2012.03.013  0.524
2012 Donigan KA, Hile SE, Eckert KA, Sweasy JB. The human gastric cancer-associated DNA polymerase β variant D160N is a mutator that induces cellular transformation. Dna Repair. 11: 381-90. PMID 22341651 DOI: 10.1016/J.Dnarep.2012.01.004  0.821
2012 Wallace SS, Murphy DL, Sweasy JB. Base excision repair and cancer. Cancer Letters. 327: 73-89. PMID 22252118 DOI: 10.1016/J.Canlet.2011.12.038  0.456
2012 Hansen J, Chan G, Liu Y, Gera J, Sweasy J, Sung P, Rockwell S, Nishimura R, Weisbart R, Glazer P. A Rare Cell-penetrating Anti-DNA Antibody Inhibits DNA Repair, Sensitizes Tumors To DNA-damaging Therapy, and is Synthetically Lethal to BRCA2-deficient Cancer Cells International Journal of Radiation Oncology*Biology*Physics. 84: S163. DOI: 10.1016/J.Ijrobp.2012.07.422  0.534
2011 Odell ID, Barbour JE, Murphy DL, Della-Maria JA, Sweasy JB, Tomkinson AE, Wallace SS, Pederson DS. Nucleosome disruption by DNA ligase III-XRCC1 promotes efficient base excision repair. Molecular and Cellular Biology. 31: 4623-32. PMID 21930793 DOI: 10.1128/Mcb.05715-11  0.545
2011 Murphy DL, Jaeger J, Sweasy JB. A triad interaction in the fingers subdomain of DNA polymerase beta controls polymerase activity. Journal of the American Chemical Society. 133: 6279-87. PMID 21452873 DOI: 10.1021/Ja111099B  0.572
2011 Kidane D, Dalal S, Keh A, Liu Y, Zelterman D, Sweasy JB. DNA polymerase beta is critical for genomic stability of sperm cells. Dna Repair. 10: 390-7. PMID 21333614 DOI: 10.1016/J.Dnarep.2011.01.003  0.566
2011 Nemec AA, Donigan KA, Murphy DL, Jaeger J, Sweasy JB. Abstract B37: A DNA polymerase beta gene harboring the colon cancer-associated G231D variant increases the sensitivity of cells to chemotherapeutic agents and induces cellular transformation Cancer Research. 71. DOI: 10.1158/1538-7445.Fbcr11-B37  0.839
2010 Nemec AA, Wallace SS, Sweasy JB. Variant base excision repair proteins: contributors to genomic instability. Seminars in Cancer Biology. 20: 320-8. PMID 20955798 DOI: 10.1016/J.Semcancer.2010.10.010  0.587
2010 Li SX, Sjolund A, Harris L, Sweasy JB. DNA repair and personalized breast cancer therapy. Environmental and Molecular Mutagenesis. 51: 897-908. PMID 20872853 DOI: 10.1002/Em.20606  0.41
2010 Senejani AG, Sweasy JB. Eukaryotic gene invasion by a bacterial mobile insertion sequence element IS2 during cloning into a plasmid vector. Genome Integrity. 1: 2. PMID 20678256 DOI: 10.1186/2041-9414-1-2  0.354
2010 Yamtich J, Starcevic D, Lauper J, Smith E, Shi I, Rangarajan S, Jaeger J, Sweasy JB. Hinge residue I174 is critical for proper dNTP selection by DNA polymerase beta. Biochemistry. 49: 2326-34. PMID 20108981 DOI: 10.1021/Bi901735A  0.817
2010 Stachelek GC, Dalal S, Donigan KA, Campisi Hegan D, Sweasy JB, Glazer PM. Potentiation of temozolomide cytotoxicity by inhibition of DNA polymerase beta is accentuated by BRCA2 mutation. Cancer Research. 70: 409-17. PMID 20028873 DOI: 10.1158/0008-5472.Can-09-1353  0.86
2010 Kidane D, Jonason AS, Gorton TS, Mihaylov I, Pan J, Keeney S, de Rooij DG, Ashley T, Keh A, Liu Y, Banerjee U, Zelterman D, Sweasy JB. DNA polymerase beta is critical for mouse meiotic synapsis. The Embo Journal. 29: 410-23. PMID 20019666 DOI: 10.1038/Emboj.2009.357  0.784
2010 Yamtich J, Sweasy JB. DNA polymerase family X: function, structure, and cellular roles. Biochimica Et Biophysica Acta. 1804: 1136-50. PMID 19631767 DOI: 10.1016/J.Bbapap.2009.07.008  0.83
2009 Donigan KA, Sweasy JB. Sequence context-specific mutagenesis and base excision repair. Molecular Carcinogenesis. 48: 362-8. PMID 19306280 DOI: 10.1002/Mc.20497  0.812
2009 Yamtich J, Speed WC, Straka E, Kidd JR, Sweasy JB, Kidd KK. Population-specific variation in haplotype composition and heterozygosity at the POLB locus. Dna Repair. 8: 579-84. PMID 19167932 DOI: 10.1016/J.Dnarep.2008.12.005  0.821
2009 Lin GC, Jaeger J, Eckert KA, Sweasy JB. Loop II of DNA polymerase beta is important for discrimination during substrate binding. Dna Repair. 8: 182-9. PMID 19013261 DOI: 10.1016/J.Dnarep.2008.10.006  0.533
2008 Dalal S, Starcevic D, Jaeger J, Sweasy JB. The I260Q variant of DNA polymerase beta extends mispaired primer termini due to its increased affinity for deoxynucleotide triphosphate substrates. Biochemistry. 47: 12118-25. PMID 18937502 DOI: 10.1021/Bi8011548  0.848
2008 Murphy DL, Kosa J, Jaeger J, Sweasy JB. The Asp285 variant of DNA polymerase beta extends mispaired primer termini via increased nucleotide binding. Biochemistry. 47: 8048-57. PMID 18616290 DOI: 10.1021/Bi702104Y  0.566
2008 Dalal S, Chikova A, Jaeger J, Sweasy JB. The Leu22Pro tumor-associated variant of DNA polymerase beta is dRP lyase deficient. Nucleic Acids Research. 36: 411-22. PMID 18039710 DOI: 10.1093/Nar/Gkm1053  0.628
2007 Lang T, Dalal S, Chikova A, DiMaio D, Sweasy JB. The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation. Molecular and Cellular Biology. 27: 5587-96. PMID 17526740 DOI: 10.1128/Mcb.01883-06  0.526
2007 Lin GC, Jaeger J, Sweasy JB. Loop II of DNA polymerase beta is important for polymerization activity and fidelity. Nucleic Acids Research. 35: 2924-35. PMID 17439962 DOI: 10.1093/Nar/Gkm126  0.553
2006 Sweasy JB, Lauper JM, Eckert KA. DNA polymerases and human diseases. Radiation Research. 166: 693-714. PMID 17067213 DOI: 10.1667/Rr0706.1  0.578
2006 Sweasy JB, Lang T, DiMaio D. Is base excision repair a tumor suppressor mechanism? Cell Cycle (Georgetown, Tex.). 5: 250-9. PMID 16418580 DOI: 10.4161/Cc.5.3.2414  0.581
2006 Sterling CH, Sweasy JB. DNA polymerase 4 of Saccharomyces cerevisiae is important for accurate repair of methyl-methanesulfonate-induced DNA damage. Genetics. 172: 89-98. PMID 16219787 DOI: 10.1534/Genetics.105.049254  0.793
2005 Dalal S, Hile S, Eckert KA, Sun KW, Starcevic D, Sweasy JB. Prostate-cancer-associated I260M variant of DNA polymerase beta is a sequence-specific mutator. Biochemistry. 44: 15664-73. PMID 16313169 DOI: 10.1021/Bi051179Z  0.845
2005 Sweasy JB, Lang T, Starcevic D, Sun KW, Lai CC, Dimaio D, Dalal S. Expression of DNA polymerase {beta} cancer-associated variants in mouse cells results in cellular transformation. Proceedings of the National Academy of Sciences of the United States of America. 102: 14350-5. PMID 16179390 DOI: 10.1073/Pnas.0505166102  0.852
2005 Starcevic D, Dalal S, Jaeger J, Sweasy JB. The hydrophobic hinge region of rat DNA polymerase beta is critical for substrate binding pocket geometry. The Journal of Biological Chemistry. 280: 28388-93. PMID 15901725 DOI: 10.1074/Jbc.M502178200  0.828
2005 Starcevic D, Dalal S, Sweasy J. Hinge residue Ile260 of DNA polymerase beta is important for enzyme activity and fidelity. Biochemistry. 44: 3775-84. PMID 15751954 DOI: 10.1021/Bi047956X  0.841
2005 Sweasy JB. RecA kicks Pol V into gear. Nature Structural & Molecular Biology. 12: 215-6. PMID 15744322 DOI: 10.1038/Nsmb0305-215  0.327
2004 Starcevic D, Dalal S, Sweasy JB. Is there a link between DNA polymerase beta and cancer? Cell Cycle (Georgetown, Tex.). 3: 998-1001. PMID 15280658 DOI: 10.4161/Cc.3.8.1062  0.861
2004 Fotiadou P, Henegariu O, Sweasy JB. DNA polymerase beta interacts with TRF2 and induces telomere dysfunction in a murine mammary cell line. Cancer Research. 64: 3830-7. PMID 15172990 DOI: 10.1158/0008-5472.Can-04-0136  0.569
2004 Lang T, Maitra M, Starcevic D, Li SX, Sweasy JB. A DNA polymerase beta mutant from colon cancer cells induces mutations. Proceedings of the National Academy of Sciences of the United States of America. 101: 6074-9. PMID 15075389 DOI: 10.1073/Pnas.0308571101  0.861
2004 Dalal S, Kosa JL, Sweasy JB. The D246V mutant of DNA polymerase beta misincorporates nucleotides: evidence for a role for the flexible loop in DNA positioning within the active site. The Journal of Biological Chemistry. 279: 577-84. PMID 14563842 DOI: 10.1074/Jbc.M309607200  0.606
2003 Shah AM, Maitra M, Sweasy JB. Variants of DNA polymerase Beta extend mispaired DNA due to increased affinity for nucleotide substrate. Biochemistry. 42: 10709-17. PMID 12962495 DOI: 10.1021/Bi034885D  0.617
2003 Sweasy JB. Fidelity mechanisms of DNA polymerase beta. Progress in Nucleic Acid Research and Molecular Biology. 73: 137-69. PMID 12882517 DOI: 10.1016/S0079-6603(03)01005-5  0.519
2002 Maitra M, Gudzelak A, Li SX, Matsumoto Y, Eckert KA, Jager J, Sweasy JB. Threonine 79 is a hinge residue that governs the fidelity of DNA polymerase beta by helping to position the DNA within the active site. The Journal of Biological Chemistry. 277: 35550-60. PMID 12121998 DOI: 10.1074/jbc.M204953200  0.533
2001 Jonason AS, Baker SM, Sweasy JB. Interaction of DNA polymerase beta with GRIP1 during meiosis. Chromosoma. 110: 402-10. PMID 11734998 DOI: 10.1007/S004120100165  0.775
2001 Shah AM, Conn DA, Li SX, Capaldi A, Jäger J, Sweasy JB. A DNA polymerase beta mutator mutant with reduced nucleotide discrimination and increased protein stability. Biochemistry. 40: 11372-81. PMID 11560485 DOI: 10.1021/Bi010755Y  0.566
2001 Shah AM, Li SX, Anderson KS, Sweasy JB. Y265H mutator mutant of DNA polymerase beta. Proper teometric alignment is critical for fidelity. The Journal of Biological Chemistry. 276: 10824-31. PMID 11154692 DOI: 10.1074/Jbc.M008680200  0.63
2000 Kosa JL, Sweasy JB. The E249K mutator mutant of DNA polymerase beta extends mispaired termini. The Journal of Biological Chemistry. 274: 35866-72. PMID 10585471 DOI: 10.1074/Jbc.274.50.35866  0.563
1999 Clairmont CA, Narayanan L, Sun KW, Glazer PM, Sweasy JB. The Tyr-265-to-Cys mutator mutant of DNA polymerase beta induces a mutator phenotype in mouse LN12 cells. Proceedings of the National Academy of Sciences of the United States of America. 96: 9580-5. PMID 10449735 DOI: 10.1073/Pnas.96.17.9580  0.606
1999 Li SX, Vaccaro JA, Sweasy JB. Involvement of phenylalanine 272 of DNA polymerase beta in discriminating between correct and incorrect deoxynucleoside triphosphates. Biochemistry. 38: 4800-8. PMID 10200168 DOI: 10.1021/Bi9827058  0.547
1999 Kosa JL, Sweasy JB. 3'-Azido-3'-deoxythymidine-resistant mutants of DNA polymerase beta identified by in vivo selection. The Journal of Biological Chemistry. 274: 3851-8. PMID 9920940 DOI: 10.1074/Jbc.274.6.3851  0.536
1998 Clairmont CA, Sweasy JB. The Pol beta-14 dominant negative rat DNA polymerase beta mutator mutant commits errors during the gap-filling step of base excision repair in Saccharomyces cerevisiae. Journal of Bacteriology. 180: 2292-7. PMID 9573177 DOI: 10.1128/Jb.180.9.2292-2297.1998  0.539
1998 Opresko PL, Sweasy JB, Eckert KA. The mutator form of polymerase beta with amino acid substitution at tyrosine 265 in the hinge region displays an increase in both base substitution and frame shift errors. Biochemistry. 37: 2111-9. PMID 9485358 DOI: 10.1021/Bi9722711  0.514
1997 Chagovetz AM, Sweasy JB, Preston BD. Increased activity and fidelity of DNA polymerase β on single- nucleotide gapped DNA Journal of Biological Chemistry. 272: 27501-27504. PMID 9346877 DOI: 10.1074/Jbc.272.44.27501  0.498
1997 Plug AW, Clairmont CA, Sapi E, Ashley T, Sweasy JB. Evidence for a role for DNA polymerase beta in mammalian meiosis. Proceedings of the National Academy of Sciences of the United States of America. 94: 1327-31. PMID 9037052 DOI: 10.1073/Pnas.94.4.1327  0.527
1997 Washington SL, Yoon MS, Chagovetz AM, Li SX, Clairmont CA, Preston BD, Eckert KA, Sweasy JB. A genetic system to identify DNA polymerase beta mutator mutants. Proceedings of the National Academy of Sciences of the United States of America. 94: 1321-6. PMID 9037051 DOI: 10.1073/Pnas.94.4.1321  0.601
1996 Clairmont CA, Sweasy JB. Dominant negative rat DNA polymerase beta mutants interfere with base excision repair in Saccharomyces cerevisiae. Journal of Bacteriology. 178: 656-61. PMID 8550496 DOI: 10.1128/Jb.178.3.656-661.1996  0.602
1995 Sweasy JB, Chen M, Loeb LA. DNA polymerase β can substitute for DNA polymerase I in the initiation of plasmid DNA replication Journal of Bacteriology. 177: 2923-2925. PMID 7751308 DOI: 10.1128/Jb.177.10.2923-2925.1995  0.589
1995 Sweasy JB, Yoon MS. Characterization of DNA polymerase beta mutants with amino acid substitutions located in the C-terminal portion of the enzyme. Molecular & General Genetics : Mgg. 248: 217-24. PMID 7651344 DOI: 10.1007/Bf02190803  0.632
1994 Chang M, Burmer GC, Sweasy J, Loeb LA, Edelhoff S, Disteche CM, Yu CE, Anderson L, Oshima J, Nakura J. Evidence against DNA polymerase beta as a candidate gene for Werner syndrome. Human Genetics. 93: 507-12. PMID 8168825 DOI: 10.1007/Bf00202813  0.522
1993 Sweasy JB, Loeb LA. Detection and characterization of mammalian DNA polymerase beta mutants by functional complementation in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 90: 4626-30. PMID 8506308 DOI: 10.1073/Pnas.90.10.4626  0.533
1991 Sweasy JB, Witkin EM. Novel SOS phenotypes caused by second-site mutations in the recA430 gene of Escherichia coli. Biochimie. 73: 437-48. PMID 1911944 DOI: 10.1016/0300-9084(91)90111-D  0.337
1990 Sweasy JB, Witkin EM, Sinha N, Roegner-Maniscalco V. RecA protein of Escherichia coli has a third essential role in SOS mutator activity. Journal of Bacteriology. 172: 3030-6. PMID 2188949 DOI: 10.1128/jb.172.6.3030-3036.1990  0.363
Show low-probability matches.