Millie M. Georgiadis - Publications

Affiliations: 
Rutgers University, New Brunswick, New Brunswick, NJ, United States 
Area:
Biochemistry

72 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Das D, Duncton MAJ, Georgiadis TM, Pellicena P, Clark J, Sobol RW, Georgiadis MM, King-Underwood J, Jobes DV, Chang C, Gao Y, Deacon AM, Wilson DM. A New Drug Discovery Platform: Application to DNA Polymerase Eta and Apurinic/Apyrimidinic Endonuclease 1. International Journal of Molecular Sciences. 24. PMID 38068959 DOI: 10.3390/ijms242316637  0.567
2023 Shukla MS, Hoshika S, Benner SA, Georgiadis MM. Crystal structures of 'ALternative Isoinformational ENgineered' DNA in B-form. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 378: 20220028. PMID 36633282 DOI: 10.1098/rstb.2022.0028  0.432
2022 Racca JD, Chatterjee D, Chen YS, Rai RK, Yang Y, Georgiadis MM, Haas E, Weiss MA. Tenuous transcriptional threshold of human sex determination. II. SRY exploits water-mediated clamp at the edge of ambiguity. Frontiers in Endocrinology. 13: 1029177. PMID 36568077 DOI: 10.3389/fendo.2022.1029177  0.434
2022 Goodwin KD, Lewis MA, Long EC, Georgiadis MM. Two distinct rotations of bithiazole DNA intercalation revealed by direct comparison of crystal structures of Co(III)•bleomycin A and B bound to duplex 5'-TAGTT sites. Bioorganic & Medicinal Chemistry. 77: 117113. PMID 36516684 DOI: 10.1016/j.bmc.2022.117113  0.447
2022 Hoshika S, Shukla MS, Benner SA, Georgiadis MM. Visualizing "Alternative Isoinformational Engineered" DNA in A- and B-Forms at High Resolution. Journal of the American Chemical Society. PMID 35969672 DOI: 10.1021/jacs.2c05255  0.419
2022 Chen Q, Bates AM, Hanquier JN, Simpson E, Rusch DB, Podicheti R, Liu Y, Wek RC, Cornett EM, Georgiadis MM. Structural and genome-wide analyses suggest that transposon-derived protein SETMAR alters transcription and splicing. The Journal of Biological Chemistry. 298: 101894. PMID 35378129 DOI: 10.1016/j.jbc.2022.101894  0.439
2020 Ouaray Z, Benner SA, Georgiadis MM, Richards NGJ. Building better polymerases: Engineering the replication of expanded genetic alphabets. The Journal of Biological Chemistry. 295: 17046-17059. PMID 33453957 DOI: 10.1074/jbc.REV120.013745  0.404
2020 Wilson DM, Deacon AM, Duncton MAJ, Pellicena P, Georgiadis MM, Yeh AP, Arvai AS, Moiani D, Tainer JA, Das D. Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response. Progress in Biophysics and Molecular Biology. PMID 33115610 DOI: 10.1016/j.pbiomolbio.2020.10.005  0.585
2020 Ouaray Z, Benner SA, Georgiadis MM, Richards NGJ. Building better DNA polymerases: Engineering the replication of expanded genetic alphabets. The Journal of Biological Chemistry. PMID 33004440 DOI: 10.1074/jbc.REV120.013745  0.409
2019 Ouaray Z, Singh I, Georgiadis MM, Richards NGJ. Building Better Enzymes: Molecular Basis of Improved Non-Natural Nucleobase Incorporation by an Evolved DNA Polymerase. Protein Science : a Publication of the Protein Society. PMID 31654473 DOI: 10.1002/Pro.3762  0.409
2019 Hoshika S, Leal NA, Kim MJ, Kim MS, Karalkar NB, Kim HJ, Bates AM, Watkins NE, SantaLucia HA, Meyer AJ, DasGupta S, Piccirilli JA, Ellington AD, SantaLucia J, Georgiadis MM, et al. Hachimoji DNA and RNA: A genetic system with eight building blocks. Science (New York, N.Y.). 363: 884-887. PMID 30792304 DOI: 10.1126/Science.Aat0971  0.505
2019 Trilles R, Beglov D, Chen Q, He H, Wireman R, Reed A, Chennamadhavuni S, Panek JS, Brown LE, Vajda S, Porco JA, Kelley MR, Georgiadis MM. Discovery of macrocyclic inhibitors of Apurinic/apyrimidinic endonuclease 1. Journal of Medicinal Chemistry. PMID 30653918 DOI: 10.1021/Acs.Jmedchem.8B01529  0.413
2018 Hoshika S, Singh I, Switzer C, Molt RW, Leal NA, Kim MJ, Kim MS, Kim HJ, Georgiadis MM, Benner SA. "Skinny" and "Fat" DNA: Two New Double Helices. Journal of the American Chemical Society. PMID 30148365 DOI: 10.1021/Jacs.8B05042  0.397
2018 Singh I, Laos R, Hoshika S, Benner SA, Georgiadis MM. Snapshots of an evolved DNA polymerase pre- and post-incorporation of an unnatural nucleotide. Nucleic Acids Research. PMID 29986111 DOI: 10.1093/Nar/Gky552  0.401
2017 Singh I, Kim MJ, Molt RW, Hoshika S, Benner SA, Georgiadis MM. Structure and Biophysics for a Six Letter DNA Alphabet that Includes Imidazo[1,2-a]-1,3,5-triazine-2(8H)-4(3H)-dione (X) and 2,4-Diaminopyrimidine (K). Acs Synthetic Biology. PMID 28752992 DOI: 10.1021/Acssynbio.7B00150  0.37
2017 Richards NGJ, Georgiadis MM. Toward an Expanded Genome: Structural and Computational Characterization of an Artificially Expanded Genetic Information System. Accounts of Chemical Research. 50: 1375-1382. PMID 28594167 DOI: 10.1021/Acs.Accounts.6B00655  0.527
2017 Molt RW, Georgiadis MM, Richards NGJ. Consecutive non-natural PZ nucleobase pairs in DNA impact helical structure as seen in 50 μs molecular dynamics simulations. Nucleic Acids Research. 45: 3643-3653. PMID 28334863 DOI: 10.1093/Nar/Gkx144  0.462
2016 Chen Q, Georgiadis M. Crystallization of and selenomethionine phasing strategy for a SETMAR-DNA complex. Acta Crystallographica. Section F, Structural Biology Communications. 72: 713-9. PMID 27599863 DOI: 10.1107/S2053230X16012723  0.58
2016 Georgiadis MM, Chen Q, Meng J, Guo C, Wireman R, Reed A, Vasko MR, Kelley MR. Small molecule activation of apurinic/apyrimidinic endonuclease 1 reduces DNA damage induced by cisplatin in cultured sensory neurons. Dna Repair. 41: 32-41. PMID 27078577 DOI: 10.1016/J.Dnarep.2016.03.009  0.376
2015 Georgiadis MM, Singh I, Kellett WF, Hoshika S, Benner SA, Richards NG. Structural basis for a six nucleotide genetic alphabet. Journal of the American Chemical Society. 137: 6947-55. PMID 25961938 DOI: 10.1021/Jacs.5B03482  0.424
2014 He H, Chen Q, Georgiadis MM. High-resolution crystal structures reveal plasticity in the metal binding site of apurinic/apyrimidinic endonuclease I. Biochemistry. 53: 6520-9. PMID 25251148 DOI: 10.1021/Bi500676P  0.404
2014 He H, Singh I, Wek SA, Dey S, Baird TD, Wek RC, Georgiadis MM. Crystal structures of GCN2 protein kinase C-terminal domains suggest regulatory differences in yeast and mammals. The Journal of Biological Chemistry. 289: 15023-34. PMID 24719324 DOI: 10.1074/Jbc.M114.560789  0.344
2014 Singh I, Jian Y, Lian Y, Li L, Georgiadis MM. The structure of an authentic spore photoproduct lesion in DNA suggests a basis for recognition. Acta Crystallographica. Section D, Biological Crystallography. 70: 752-9. PMID 24598744 DOI: 10.1107/S1399004713032987  0.411
2014 Kim HS, Chen Q, Kim SK, Nickoloff JA, Hromas R, Georgiadis MM, Lee SH. The DDN catalytic motif is required for Metnase functions in non-homologous end joining (NHEJ) repair and replication restart. The Journal of Biological Chemistry. 289: 10930-8. PMID 24573677 DOI: 10.1074/Jbc.M113.533216  0.553
2014 Chen Q, Lee S, Georgiadis M. Preliminary crystallographic analysis of SETMAR bound to DNA Acta Crystallographica Section a Foundations and Advances. 70: C206-C206. DOI: 10.1107/S2053273314097939  0.578
2014 Singh I, He H, Wek S, Dey S, Baird T, Wek R, Georgiadis M. Crystal structures of GCN2 C-terminal domain: Insight into GCN2 regulation Acta Crystallographica Section a Foundations and Advances. 70: C1407-C1407. DOI: 10.1107/S2053273314085921  0.431
2014 Singh I, Jian Y, Li L, Georgiadis MM. The structure of an authentic spore photoproduct lesion in DNA suggests a basis for recognition. Corrigendum Acta Crystallographica Section D Biological Crystallography. 70: 1173-1173. DOI: 10.1107/S1399004714006130  0.339
2013 Zhang J, Luo M, Marasco D, Logsdon D, LaFavers KA, Chen Q, Reed A, Kelley MR, Gross ML, Georgiadis MM. Inhibition of apurinic/apyrimidinic endonuclease I's redox activity revisited. Biochemistry. 52: 2955-66. PMID 23597102 DOI: 10.1021/Bi400179M  0.307
2012 Kelley MR, Georgiadis MM, Fishel ML. APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1. Current Molecular Pharmacology. 5: 36-53. PMID 22122463 DOI: 10.2174/1874467211205010036  0.336
2011 Kim YJ, Kim D, Illuzzi JL, Delaplane S, Su D, Bernier M, Gross ML, Georgiadis MM, Wilson DM. S-glutathionylation of cysteine 99 in the APE1 protein impairs abasic endonuclease activity. Journal of Molecular Biology. 414: 313-26. PMID 22024594 DOI: 10.1016/J.Jmb.2011.10.023  0.502
2011 Onyango DO, Naguleswaran A, Delaplane S, Reed A, Kelley MR, Georgiadis MM, Sullivan WJ. Base excision repair apurinic/apyrimidinic endonucleases in apicomplexan parasite Toxoplasma gondii. Dna Repair. 10: 466-75. PMID 21353648 DOI: 10.1016/J.Dnarep.2011.01.011  0.464
2011 Su D, Delaplane S, Luo M, Rempel DL, Vu B, Kelley MR, Gross ML, Georgiadis MM. Interactions of apurinic/apyrimidinic endonuclease with a redox inhibitor: evidence for an alternate conformation of the enzyme. Biochemistry. 50: 82-92. PMID 21117647 DOI: 10.1021/Bi101248S  0.338
2011 Kelley MR, Luo M, Reed A, Su D, Delaplane S, Borch RF, Nyland RL, Gross ML, Georgiadis MM. Functional analysis of novel analogues of E3330 that block the redox signaling activity of the multifunctional AP endonuclease/redox signaling enzyme APE1/Ref-1. Antioxidants & Redox Signaling. 14: 1387-401. PMID 20874257 DOI: 10.1089/Ars.2010.3410  0.317
2010 Anciano Granadillo VJ, Earley JN, Shuck SC, Georgiadis MM, Fitch RW, Turchi JJ. Targeting the OB-Folds of Replication Protein A with Small Molecules. Journal of Nucleic Acids. 2010: 304035. PMID 21188165 DOI: 10.4061/2010/304035  0.45
2010 Goodwin KD, He H, Imasaki T, Lee SH, Georgiadis MM. Crystal structure of the human Hsmar1-derived transposase domain in the DNA repair enzyme Metnase. Biochemistry. 49: 5705-13. PMID 20521842 DOI: 10.1021/Bi100171X  0.594
2010 Bapat A, Glass LS, Luo M, Fishel ML, Long EC, Georgiadis MM, Kelley MR. Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells. The Journal of Pharmacology and Experimental Therapeutics. 334: 988-98. PMID 20504914 DOI: 10.1124/Jpet.110.169128  0.362
2010 Glass LS, Bapat A, Kelley MR, Georgiadis MM, Long EC. Semi-automated high-throughput fluorescent intercalator displacement-based discovery of cytotoxic DNA binding agents from a large compound library. Bioorganic & Medicinal Chemistry Letters. 20: 1685-8. PMID 20144868 DOI: 10.1016/J.Bmcl.2010.01.033  0.445
2010 Luo M, He H, Kelley MR, Georgiadis MM. Redox regulation of DNA repair: implications for human health and cancer therapeutic development. Antioxidants & Redox Signaling. 12: 1247-69. PMID 19764832 DOI: 10.1089/Ars.2009.2698  0.454
2010 Bapat A, Glass LS, Luo M, Fishel ML, Reed A, Long EC, Georgiadis MM, Kelley MR. Abstract 1963: Novel small molecule inhibitor of the endonuclease function of the APE1 DNA repair and redox signaling enzyme blocks proliferation and reduces viability of glioblastoma cells Cellular and Molecular Biology. 70: 1963-1963. DOI: 10.1158/1538-7445.Am10-1963  0.38
2009 Glass LS, Nguyen B, Goodwin KD, Dardonville C, Wilson WD, Long EC, Georgiadis MM. Crystal structure of a trypanocidal 4,4'-bis(imidazolinylamino)diphenylamine bound to DNA. Biochemistry. 48: 5943-52. PMID 19405506 DOI: 10.1021/Bi900204W  0.461
2009 Long EC, Georgiadis MM, Goodwin KD, Lewis MA. New approaches to analyzing the site selectivities and crystal structures of DNA targeted metal complexes: Analysis of the antitumor agent bleomycin Acs Symposium Series. 1012: 63-80. DOI: 10.1021/bk-2009-1012.ch005  0.302
2008 Luo M, Delaplane S, Jiang A, Reed A, He Y, Fishel M, Nyland RL, Borch RF, Qiao X, Georgiadis MM, Kelley MR. Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1. Antioxidants & Redox Signaling. 10: 1853-67. PMID 18627350 DOI: 10.1089/Ars.2008.2120  0.43
2008 Georgiadis MM, Luo M, Gaur RK, Delaplane S, Li X, Kelley MR. Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 643: 54-63. PMID 18579163 DOI: 10.1016/J.Mrfmmm.2008.04.008  0.358
2008 Goodwin KD, Lewis MA, Long EC, Georgiadis MM. Crystal structure of DNA-bound Co(III) bleomycin B2: Insights on intercalation and minor groove binding. Proceedings of the National Academy of Sciences of the United States of America. 105: 5052-6. PMID 18362349 DOI: 10.1073/Pnas.0708143105  0.555
2008 Georgiadis M, Goodwin K, Lewis M, Long E. Crystal structures of DNA-bound Co(III)·bleomycins Acta Crystallographica Section a Foundations of Crystallography. 64: C156-C156. DOI: 10.1107/S0108767308094968  0.492
2007 Roman Y, Oshige M, Lee YJ, Goodwin K, Georgiadis MM, Hromas RA, Lee SH. Biochemical characterization of a SET and transposase fusion protein, Metnase: its DNA binding and DNA cleavage activity. Biochemistry. 46: 11369-76. PMID 17877369 DOI: 10.1021/Bi7005477  0.562
2007 Tanious FA, Laine W, Peixoto P, Bailly C, Goodwin KD, Lewis MA, Long EC, Georgiadis MM, Tidwell RR, Wilson WD. Unusually strong binding to the DNA minor groove by a highly twisted benzimidazole diphenylether: induced fit and bound water. Biochemistry. 46: 6944-56. PMID 17506529 DOI: 10.1021/Bi700288G  0.448
2007 Luo Y, Kwon HJ, Montano S, Georgiadis M, Goebl MG, Harrington MA. Phosphorylation of SIMPL modulates RelA-associated NF-kappaB-dependent transcription. American Journal of Physiology. Cell Physiology. 292: C1013-23. PMID 17079333 DOI: 10.1152/Ajpcell.00456.2006  0.704
2006 Haag Breese E, Uversky VN, Georgiadis MM, Harrington MA. The disordered amino-terminus of SIMPL interacts with members of the 70-kDa heat-shock protein family. Dna and Cell Biology. 25: 704-14. PMID 17233114 DOI: 10.1089/Dna.2006.25.704  0.36
2006 Montaño SP, Coté ML, Roth MJ, Georgiadis MM. Crystal structures of oligonucleotides including the integrase processing site of the Moloney murine leukemia virus. Nucleic Acids Research. 34: 5353-60. PMID 17003051 DOI: 10.1093/Nar/Gkl693  0.751
2006 Goodwin KD, Lewis MA, Tanious FA, Tidwell RR, Wilson WD, Georgiadis MM, Long EC. A high-throughput, high-resolution strategy for the study of site-selective DNA binding agents: analysis of a "highly twisted" benzimidazole-diamidine. Journal of the American Chemical Society. 128: 7846-54. PMID 16771498 DOI: 10.1021/Ja0600936  0.473
2005 Crowther RL, Georgiadis MM. The crystal structure of 5-keto-4-deoxyuronate isomerase from Escherichia coli. Proteins. 61: 680-4. PMID 16152643 DOI: 10.1002/Prot.20598  0.688
2005 Goodwin KD, Long EC, Georgiadis MM. A host-guest approach for determining drug-DNA interactions: an example using netropsin. Nucleic Acids Research. 33: 4106-16. PMID 16049022 DOI: 10.1093/Nar/Gki717  0.571
2004 Crowther RL, Remeta DP, Minetti CA, Das D, Montano SP, Georgiadis MM. Structural and energetic characterization of nucleic acid-binding to the fingers domain of Moloney murine leukemia virus reverse transcriptase. Proteins. 57: 15-26. PMID 15326591 DOI: 10.1002/Prot.20224  0.765
2004 Fingerman IM, Sutphen K, Montano SP, Georgiadis MM, Vershon AK. Characterization of critical interactions between Ndt80 and MSE DNA defining a novel family of Ig-fold transcription factors. Nucleic Acids Research. 32: 2947-56. PMID 15161958 DOI: 10.1093/Nar/Gkh625  0.797
2004 Das D, Georgiadis MM. The crystal structure of the monomeric reverse transcriptase from Moloney murine leukemia virus. Structure (London, England : 1993). 12: 819-29. PMID 15130474 DOI: 10.1016/J.Str.2004.02.032  0.681
2003 Pierce M, Benjamin KR, Montano SP, Georgiadis MM, Winter E, Vershon AK. Sum1 and Ndt80 proteins compete for binding to middle sporulation element sequences that control meiotic gene expression. Molecular and Cellular Biology. 23: 4814-25. PMID 12832469 DOI: 10.1128/Mcb.23.14.4814-4825.2003  0.746
2003 Coté ML, Pflomm M, Georgiadis MM. Staying straight with A-tracts: a DNA analog of the HIV-1 polypurine tract. Journal of Molecular Biology. 330: 57-74. PMID 12818202 DOI: 10.1016/S0022-2836(03)00554-0  0.5
2002 Montano SP, Pierce M, Coté ML, Vershon AK, Georgiadis MM. Crystallographic studies of a novel DNA-binding domain from the yeast transcriptional activator Ndt80. Acta Crystallographica. Section D, Biological Crystallography. 58: 2127-30. PMID 12454476 DOI: 10.1107/S0907444902015020  0.8
2002 Montano SP, Coté ML, Fingerman I, Pierce M, Vershon AK, Georgiadis MM. Crystal structure of the DNA-binding domain from Ndt80, a transcriptional activator required for meiosis in yeast. Proceedings of the National Academy of Sciences of the United States of America. 99: 14041-6. PMID 12384578 DOI: 10.1073/Pnas.222312199  0.806
2002 Ho DN, Coburn GA, Kang Y, Cullen BR, Georgiadis MM. The crystal structure and mutational analysis of a novel RNA-binding domain found in the human Tap nuclear mRNA export factor. Proceedings of the National Academy of Sciences of the United States of America. 99: 1888-93. PMID 11854490 DOI: 10.1073/Pnas.042698599  0.736
2001 Das D, Georgiadis MM. A directed approach to improving the solubility of Moloney murine leukemia virus reverse transcriptase. Protein Science : a Publication of the Protein Society. 10: 1936-41. PMID 11567084 DOI: 10.1110/Ps.16301  0.595
2001 Coté ML, Georgiadis MM. Structure of a pseudo-16-mer DNA with stacked guanines and two G-A mispairs complexed with the N-terminal fragment of Moloney murine leukemia virus reverse transcriptase. Acta Crystallographica. Section D, Biological Crystallography. 57: 1238-50. PMID 11526315 DOI: 10.1107/S090744490100943X  0.45
2001 Coburn GA, Wiegand HL, Kang Y, Ho DN, Georgiadis MM, Cullen BR. Using viral species specificity to define a critical protein/RNA interaction surface. Genes & Development. 15: 1194-205. PMID 11358864 DOI: 10.1101/Gad.888201  0.708
2001 Gu J, Villanueva RA, Snyder CS, Roth MJ, Georgiadis MM. Substitution of Asp114 or Arg116 in the fingers domain of moloney murine leukemia virus reverse transcriptase affects interactions with the template-primer resulting in decreased processivity. Journal of Molecular Biology. 305: 341-59. PMID 11124910 DOI: 10.1006/jmbi.2000.4281  0.403
2000 Coté ML, Yohannan SJ, Georgiadis MM. Use of an N-terminal fragment from moloney murine leukemia virus reverse transcriptase to facilitate crystallization and analysis of a pseudo-16-mer DNA molecule containing G-A mispairs. Acta Crystallographica. Section D, Biological Crystallography. 56: 1120-31. PMID 10957631 DOI: 10.1107/S0907444900008246  0.436
2000 Najmudin S, Coté ML, Sun D, Yohannan S, Montano SP, Gu J, Georgiadis MM. Crystal structures of an N-terminal fragment from Moloney murine leukemia virus reverse transcriptase complexed with nucleic acid: functional implications for template-primer binding to the fingers domain. Journal of Molecular Biology. 296: 613-32. PMID 10669612 DOI: 10.1006/Jmbi.1999.3477  0.802
1998 Sun D, Jessen S, Liu C, Liu X, Najmudin S, Georgiadis MM. Cloning, expression, and purification of a catalytic fragment of Moloney murine leukemia virus reverse transcriptase: crystallization of nucleic acid complexes. Protein Science : a Publication of the Protein Society. 7: 1575-82. PMID 9684890 DOI: 10.1002/pro.5560070711  0.424
1997 Gao G, Orlova M, Georgiadis MM, Hendrickson WA, Goff SP. Conferring RNA polymerase activity to a DNA polymerase: a single residue in reverse transcriptase controls substrate selection. Proceedings of the National Academy of Sciences of the United States of America. 94: 407-11. PMID 9012795 DOI: 10.1073/Pnas.94.2.407  0.561
1995 Georgiadis MM, Jessen SM, Ogata CM, Telesnitsky A, Goff SP, Hendrickson WA. Mechanistic implications from the structure of a catalytic fragment of Moloney murine leukemia virus reverse transcriptase. Structure (London, England : 1993). 3: 879-92. PMID 8535782 DOI: 10.1016/S0969-2126(01)00223-4  0.614
1995 Wöhrl BM, Georgiadis MM, Telesnitsky A, Hendrickson WA, Le Grice SFJ. Footprint analysis of replicating murine leukemia virus reverse transcriptase Science. 267: 96-99. PMID 7528942 DOI: 10.1126/Science.7528942  0.584
1993 Kim J, Georgiadis MM, Chan MK, Woo D, Komiya H, Rees DC. Nitrogenase: Crystal structures and function. Journal of Inorganic Biochemistry. 51: 2. DOI: 10.1016/0162-0134(93)85041-6  0.47
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